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9 results on '"Plaszczyca, Anna"'

1. A Randomized Open label Phase-II Clinical Trial with or without Infusion of Plasma from Subjects after Convalescence of SARS-CoV-2 Infection in High-Risk Patients with Confirmed Severe SARS-CoV-2 Disease (RECOVER): A structured summary of a study protocol for a randomised controlled trial

Author

Janssen, Maike, Schäkel, Ulrike, Djuka Fokou, Carine, Krisam, Johannes, Stermann, Jacek, Kriegsmann, Katharina, Haberbosch, Isabella, Novotny, Jan Philipp, Weber, Stefan, Vehreschild, Maria, Bornhäuser, Martin, Bullinger, Lars, Schmitt, Michael, Liebregts, Tobias, Dreger, Peter, Lorenz, Hanns-Martin, Plaszczyca, Anna, Bartenschlager, Ralf, Müller, Barbara, Kräusslich, Hans-Georg, Halama, Niels, Jäger, Dirk, Schlenk, Richard F., Leo, Albrecht, Meuer, Stefan, Weigand, Markus A., Motsch, Johann, Merle, Uta, Denkinger, Claudia M., and Müller-Tidow, Carsten

Published
2020
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2. An orthogonal proteomic survey uncovers novel Zika virus host factors

Author

Scaturro, Pietro, Stukalov, Alexey, Haas, Darya A., Cortese, Mirko, Draganova, Kalina, Plaszczyca, Anna, and Bartenschlager, Ralf

Subjects
Proteomics -- Methods, Zika virus -- Health aspects, Host-virus relationships -- Observations, Neurologic manifestations, Neurons, Infertility, Virus diseases, Stem cell research, Infection, Proteins, Medical research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Zika virus (ZIKV) has recently emerged as a global health concern owing to its widespread diffusion and its association with severe neurological symptoms and microcephaly in newborns.sup.1. However, the molecular mechanisms that are responsible for the pathogenicity of ZIKV remain largely unknown. Here we use human neural progenitor cells and the neuronal cell line SK-N-BE2 in an integrated proteomics approach to characterize the cellular responses to viral infection at the proteome and phosphoproteome level, and use affinity proteomics to identify cellular targets of ZIKV proteins. Using this approach, we identify 386 ZIKV-interacting proteins, ZIKV-specific and pan-flaviviral activities as well as host factors with known functions in neuronal development, retinal defects and infertility. Moreover, our analysis identified 1,216 phosphorylation sites that are specifically up- or downregulated after ZIKV infection, indicating profound modulation of fundamental signalling pathways such as AKT, MAPK-ERK and ATM-ATR and thereby providing mechanistic insights into the proliferation arrest elicited by ZIKV infection. Functionally, our integrative study identifies ZIKV host-dependency factors and provides a comprehensive framework for a system-level understanding of ZIKV-induced perturbations at the levels of proteins and cellular pathways.Integrative analyses identify host proteins that are modulated by Zika virus at multiple levels and provide a comprehensive framework for the understanding of Zika virus-induced changes to cellular pathways., Author(s): Pietro Scaturro [sup.1] [sup.2] , Alexey Stukalov [sup.1] [sup.2] , Darya A. Haas [sup.1] , Mirko Cortese [sup.3] , Kalina Draganova [sup.4] [sup.5] , Anna Plaszczyca [sup.3] , Ralf [...]

Published
2018
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4. Prevalence of SARS-CoV-2 Infection in Children and Their Parents in Southwest Germany

Author

Tönshoff, Burkhard, primary, Müller, Barbara, additional, Elling, Roland, additional, Renk, Hanna, additional, Meissner, Peter, additional, Hengel, Hartmut, additional, Garbade, Sven F., additional, Kieser, Meinhard, additional, Jeltsch, Kathrin, additional, Grulich-Henn, Jürgen, additional, Euler, Julia, additional, Stich, Maximilian, additional, Chobanyan-Jürgens, Kristine, additional, Zernickel, Maria, additional, Janda, Aleš, additional, Wölfle, Lena, additional, Stamminger, Thomas, additional, Iftner, Thomas, additional, Ganzenmueller, Tina, additional, Schmitt, Christian, additional, Görne, Tessa, additional, Laketa, Vibor, additional, Olberg, Sylvia, additional, Plaszczyca, Anna, additional, Cortese, Mirko, additional, Bartenschlager, Ralf, additional, Pape, Constantin, additional, Remme, Roman, additional, Huzly, Daniela, additional, Panning, Marcus, additional, Weigang, Sebastian, additional, Giese, Sebastian, additional, Ciminski, Kevin, additional, Ankerhold, Jakob, additional, Kochs, Georg, additional, Schwemmle, Martin, additional, Handgretinger, Rupert, additional, Niemeyer, Charlotte M., additional, Engel, Corinna, additional, Kern, Winfried V., additional, Hoffmann, Georg Friedrich, additional, Franz, Axel R., additional, Henneke, Philipp, additional, Debatin, Klaus-Michael, additional, and Kräusslich, Hans-Georg, additional

Published
2021
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5. Can we predict antibody responses in SARS-CoV-2? A cohort analysis

Author

Gaeddert, Mary, primary, Kitchen, Philip, additional, Broger, Tobias, additional, Weber, Stefan, additional, Bartenschlager, Ralf, additional, Plaszczyca, Anna, additional, Kräusslich, Hans-Georg, additional, Müller, Barbara, additional, Souto-Carneiro, Margarida, additional, Janssen, Maike, additional, Müller-Tidow, Carsten, additional, Merle, Uta, additional, Herrmann, Yannis, additional, Raedeker, Lukas, additional, Sebastian, Jakob, additional, Brindl, Niall, additional, Starck, Tim, additional, and Denkinger, Claudia M., additional

Published
2021
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6. Additional file 1 of A Randomized Open label Phase-II Clinical Trial with or without Infusion of Plasma from Subjects after Convalescence of SARS-CoV-2 Infection in High-Risk Patients with Confirmed Severe SARS-CoV-2 Disease (RECOVER): A structured summary of a study protocol for a randomised controlled trial

Author

Janssen, Maike, Schäkel, Ulrike, Fokou, Carine Djuka, Krisam, Johannes, Stermann, Jacek, Kriegsmann, Katharina, Haberbosch, Isabella, Novotny, Jan Philipp, Weber, Stefan, Vehreschild, Maria, Bornhäuser, Martin, Bullinger, Lars, Schmitt, Michael, Liebregts, Tobias, Dreger, Peter, Hanns-Martin Lorenz, Plaszczyca, Anna, Bartenschlager, Ralf, Müller, Barbara, Hans-Georg Kräusslich, Halama, Niels, Jäger, Dirk, Schlenk, Richard F., Leo, Albrecht, Meuer, Stefan, Weigand, Markus A., Motsch, Johann, Merle, Uta, Denkinger, Claudia M., and Müller-Tidow, Carsten

Subjects
Data_FILES
Abstract

Additional file 1.

Published
2020
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7. Additional file 2 of A Randomized Open label Phase-II Clinical Trial with or without Infusion of Plasma from Subjects after Convalescence of SARS-CoV-2 Infection in High-Risk Patients with Confirmed Severe SARS-CoV-2 Disease (RECOVER): A structured summary of a study protocol for a randomised controlled trial

Author

Janssen, Maike, Schäkel, Ulrike, Fokou, Carine Djuka, Krisam, Johannes, Stermann, Jacek, Kriegsmann, Katharina, Haberbosch, Isabella, Novotny, Jan Philipp, Weber, Stefan, Vehreschild, Maria, Bornhäuser, Martin, Bullinger, Lars, Schmitt, Michael, Liebregts, Tobias, Dreger, Peter, Hanns-Martin Lorenz, Plaszczyca, Anna, Bartenschlager, Ralf, Müller, Barbara, Hans-Georg Kräusslich, Halama, Niels, Jäger, Dirk, Schlenk, Richard F., Leo, Albrecht, Meuer, Stefan, Weigand, Markus A., Motsch, Johann, Merle, Uta, Denkinger, Claudia M., and Müller-Tidow, Carsten

Subjects
Data_FILES
Abstract

Additional file 2.

Published
2020
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8. Additional file 3 of A Randomized Open label Phase-II Clinical Trial with or without Infusion of Plasma from Subjects after Convalescence of SARS-CoV-2 Infection in High-Risk Patients with Confirmed Severe SARS-CoV-2 Disease (RECOVER): A structured summary of a study protocol for a randomised controlled trial

Author

Janssen, Maike, Schäkel, Ulrike, Fokou, Carine Djuka, Krisam, Johannes, Stermann, Jacek, Kriegsmann, Katharina, Haberbosch, Isabella, Novotny, Jan Philipp, Weber, Stefan, Vehreschild, Maria, Bornhäuser, Martin, Bullinger, Lars, Schmitt, Michael, Liebregts, Tobias, Dreger, Peter, Hanns-Martin Lorenz, Plaszczyca, Anna, Bartenschlager, Ralf, Müller, Barbara, Hans-Georg Kräusslich, Halama, Niels, Jäger, Dirk, Schlenk, Richard F., Leo, Albrecht, Meuer, Stefan, Weigand, Markus A., Motsch, Johann, Merle, Uta, Denkinger, Claudia M., and Müller-Tidow, Carsten

Subjects
Data_FILES
Abstract

Additional file 3.

Published
2020
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9. Serological response and disease-specific neutralizing antibodies in kidney transplant recipients with SARS-CoV-2 infection – a case series

Author

Speer, Claudius, primary, Schnitzler, Paul, additional, Giese, Thomas, additional, Plaszczyca, Anna, additional, Bartenschlager, Ralf, additional, Kälble, Florian, additional, Nusshag, Christian, additional, Morath, Christian, additional, Zeier, Martin, additional, Merle, Uta, additional, and Sommerer, Claudia, additional

Published
2020
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