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165 results on '"Plotnikoff, N."'

4. Methionine Enkephalin: Clinical Pharmacology

Author

Plotnikoff, N. P., Solomon, S., Valentine, J. L., Fesen, M., Faith, R. E., Edwards, L., Richter, R., Murgo, A. J., Miller, G. C., Plotnikoff, Nicholas P., editor, Faith, Robert E., editor, Murgo, Anthony J., editor, and Good, Robert A., editor

Published
1986
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16. Effects of thyrotropin-releasing hormone (TRH) on the actions of pentobarbital and other centrally acting drugs.

Author

Breese, G R, Cott, J M, Cooper, B R, Prange, A J, Lipton, M A, and Plotnikoff, N P

Abstract

Thyrotropin-releasing hormone (TRH) was found to antagonize pentobarbital-induced sleeping time and hypothermia. While 3 to 100 mg/kg of TRH reduced pentobarbital sleeping time when administered prior to the barbiturate, a dose-response relationship to TRH could not be established. However, doses of 10 to 100 mg/kg of TRH enhanced the lethality of pentobarbital when these compounds were administered simultaneously. Thyrotropin or L-triiodothyronine did not imitate and hypophysectomy did not reduce the effects of TRH, indicating that the pituitary is not essential for its antagonism of pentobarbital. Studies of TRH analogs provided further support of this view. In addition, TRH reduced the sleep and hypothermia produced by thiopental, amobarbital, secobarbital and phenobarbital, and it antagonized the hypothermia and reduced motor activity produced by chloral hydrate, reserpine, chlorpromazine and diazepam. Intracisternally administered TRH also reduced pentobarbital sleeping time and hypothermia, but melanocyte-stimulating hormone release-inhibiting factor and somatostatin administered by this route did not. While reduction of pentobarbital sleeping time by TRH could not be attributed to an affect on monoamine systems or to deamidated TRH, this action was reduced by intracisternally administered atropine, suggesting that cholinergic mechanisms may contribute to the effects of TRH. Thus, the results provide evidence that TRH acts on brain independent of an effect on the pituitary.

Published
1975

32. ChemInform Abstract: DRUGS DERIVED FROM CANNABINOIDS. 5. Δ6A,10A,‐TETRAHYDROCANNABINOL AND HETEROCYCLIC ANALOGS CONTAINING AROMATIC SIDE CHAINS

Author

WINN, M., primary, ARENDSEN, D., additional, DODGE, P., additional, DREN, A., additional, DUNNIGAN, D., additional, HALLAS, R., additional, HWANG, K., additional, KYNCL, J., additional, LEE, Y. H., additional, PLOTNIKOFF, N., additional, YOUNG, P., additional, ZAUGG, H., additional, DALZELL, H., additional, and RAZDAN, R. K., additional

Published
1976
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44. Methionine enkephalin in the treatment of ARC

Author

Bernard, B., Plotnikoff, N., Freeman, K., Dowling, J., Diuguid, C., and Altmann, E.

Subjects
AIDS-related complex -- Drug therapy, Enkephalin, Methionine -- Health aspects
Abstract

AUTHORS: B. Bernard, N. Plotnikoff, K. Freeman, J. Dowling, C. Diuguid and E. Altmann. Community Research Initiative, New York, New York; University of Illinois College of Pharmacy, Chicago, Illinois; Albert [...]

Published
1991

49. Methionine enkephalin, its role in immunoregulation and cancer therapy.

Author

Zhao D, Plotnikoff N, Griffin N, Song T, and Shan F

Subjects
Antineoplastic Agents metabolism, Antineoplastic Agents pharmacology, Cell Proliferation drug effects, Clinical Trials as Topic, Dendritic Cells drug effects, Dendritic Cells metabolism, Humans, Immune System drug effects, Killer Cells, Natural drug effects, Killer Cells, Natural metabolism, Macrophages drug effects, Macrophages metabolism, Neoplasms immunology, T-Lymphocytes, Regulatory drug effects, T-Lymphocytes, Regulatory metabolism, Enkephalin, Methionine metabolism, Enkephalin, Methionine pharmacology, Immune System metabolism, Immunotherapy methods, Neoplasms therapy, Neurosecretory Systems metabolism, Receptors, Opioid metabolism
Abstract

Methionine enkephalin (MENK), an endogenous neuropeptide has a crucial role in both neuroendocrine and immune systems. MENK is believed to have an immunoregulatory activity to have cancer biotherapy activity by binding to the opioid receptors on immune and cancer cells. Clinical trial studies in cancer patients have shown that MENK activates immune cells directly and by inhibiting regulatory T-cells (Tregs). MENK may also change the tumor microenvironment by binding to opioid receptor on or in cancer cells. All of these mechanisms of action have biologic significance and potential for use in cancer immunotherapy. Furthermore, they reveal a relationship between the endocrine and immune systems. Due to the apparent role of MENK in cancer therapy we reviewed herein, the research undertaken with MENK in recent years; which has advanced our understanding of the role MENK has in cancer progression and its relationship to immunity, supporting MENK as a new strategy for cancer immunotherapy., (Copyright © 2016 Elsevier B.V. All rights reserved.)

Published
2016
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50. Methionine enkephalin: a new cytokine--human studies.

Author

Plotnikoff NP, Faith RE, Murgo AJ, Herberman RB, and Good RA

Subjects
Acquired Immunodeficiency Syndrome immunology, Humans, Neoplasms immunology, Cytokines immunology, Enkephalin, Methionine immunology
Abstract

The effects of methionine enkephalin (met-enkephalin) on human immune function are reviewed. This pentapeptide functions to upregulate, or enhance, immune function in the majority of donor samples at low doses and suppresses at high doses. The influence of this molecule is shared by the central nervous, neuroendocrine, and immune systems. Cells from each of these systems possess receptors for met-enkephalin and have the ability to process met-enkephalin from its prohormone, proenkephalin A. Studies have shown that this molecule is capable of enhancing immune function in patients with cancer or AIDS. It is proposed that this molecule be classified as a cytokine.

Published
1997
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