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usc Refereed/Peer-reviewed Common cancer therapeutics suffer from serious drawbacks such as multidrug resistance and off target effects. These problems would lead to reduced patient compliance and low survival rates. There is an urgent need for more effective therapeutics for treatment of cancers patients. Pluronic based nano-particulate systems are innovative platforms for delivery of anti-cancer agents. These systems due to their pharmacological properties and suitable physicochemical characteristics are great opportunity for development cancer therapeutics. Pluronic based delivery systems are used for delivery of combinatorial therapeutic regimens as well. This mini-review tries to provide a more detailed overview on the currently available pluronic based drug delivery systems. In the section 2, pharmacological characteristics of pluronic as a therapeutic polymer are assessed. In section 3, pluronic based formulations for hydrophobic payloads and surfaced modified targeted delivery systems are analyzed. The combinatorial pluronic based systems are summarized in section 4 and at last but not least the challenges and future prospective are discussed within section 5.