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4. Reassessment of the risk of recurrence (R3) after liver transplantation for HCC: validation of the R3 score and comparison with existing models

Author

Costentin, C, Pinero, F, Degroote, H, Notarpaolo, A, Boin, I, Boudjema, K, Baccaro, C, Podesta, L, Bachellier, P, Ettorre, GM, Poniachik, J, Muscari, F, Dibenedetto, F, Duque, SH, Salame, E, Cillo, U, Gadano, A, Vanlemmens, C, Fagiuoli, S, Rubinstein, F, Burra, P, Van Vlierberghe, H, Cherqui, D, Silva, M, Duvoux, C, Costentin, C, Pinero, F, Degroote, H, Notarpaolo, A, Boin, I, Boudjema, K, Baccaro, C, Podesta, L, Bachellier, P, Ettorre, G, Poniachik, J, Muscari, F, Dibenedetto, F, Duque, S, Salame, E, Cillo, U, Gadano, A, Vanlemmens, C, Fagiuoli, S, Rubinstein, F, Burra, P, Van Vlierberghe, H, Cherqui, D, Silva, M, and Duvoux, C

Subjects
Cirrhosi, liver transplantation, alfa FP, HCC
Published
2021

10. Voltage Measurement

Author

Ferrero, A, primary, Bartoletti, C, additional, Podesta, L, additional, Sacerdoti, G, additional, and Murphy, J, additional

Published
1999
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33. Immunodepletion in xenotransplantation

Author

Shapiro, R, Tzakis, AG, Scantlebury, V, Makowka, L, Watt, R, Oks, A, Yanaga, K, Podesta, L, Casavilla, A, Wos, S, Murray, J, Oral, A, D'andrea, P, Banner, B, Starzl, TE, Shapiro, R, Tzakis, AG, Scantlebury, V, Makowka, L, Watt, R, Oks, A, Yanaga, K, Podesta, L, Casavilla, A, Wos, S, Murray, J, Oral, A, D'andrea, P, Banner, B, and Starzl, TE

Abstract

Xenograft transplantation is perhaps the most immunologically difficult problem in transplantation today. An overwhelming hyperacute rejection reaction (HAR) occurs within minutes of organ implantation. Preformed antibodies are thought to initiate this process. We used a pig-to-dog renal xenograft transplant model and investigated methods of decreasing the severity of hyperacute rejection. Female pigs weighing 15-20 kg were used as donors. Recipients were mongrel dogs weighing 15-25 kg. Experimental dogs were all given a number of treatments of IgG depletion using an antibody removal system (Dupont-Excorim). This machine immunoadsorbs plasma against a column containing immobilized staphylococcal protein A, which is known to bind the IgG Fc receptor. An 84% reduction in the IgG levels and a 71% reduction in IgM levels was achieved. Postoperative assessment was made of urine output, time to onset of HAR, and histopathological examination of the rejected kidneys. Although cross-matches between donor lymphocytes and recipient sera remained strongly positive in the treated dogs, there was a two- to fourfold reduction in the titers. The time to onset of HAR was prolonged in the experimental group, and the urine output was increased slightly. The histopathologic changes in the experimental group generally showed signs of HAR, but of less intensity than in the nonimmunodepleted control group. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

Published
1990

34. The antagonism of platelet-activating factor and hyperacute organ rejection

Author

Makowka, L, Chapman, F, Qian, S, Pascualone, A, Sico, E, Podesta, L, Mazzaferro, V, Sher, L, Sun, H, Banner, B, Zerbe, TR, Saunders, R, Starzl, TE, Makowka, L, Chapman, F, Qian, S, Pascualone, A, Sico, E, Podesta, L, Mazzaferro, V, Sher, L, Sun, H, Banner, B, Zerbe, TR, Saunders, R, and Starzl, TE

Published
1990

37. Early Clinical Experience with a Hybrid Bioartificial Liver

Author

Demetriou, A. A., primary, Rozga, J., additional, Podesta, L., additional, Lepage, E., additional, Morsiani, E., additional, Moscioni, A. D., additional, Hoffman, A., additional, McGrath, M., additional, Kong, L., additional, Rosen, H., additional, Villamil, F., additional, Woolf, G., additional, Vierling, J., additional, and Makowka, L., additional

Published
1995
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41. Immunodepletion in Xenotransplantation

Author

Shapiro, R., primary, Tzakis, A. G., additional, Scantlebury, V., additional, Makowka, L., additional, Watt, R., additional, Oks, A., additional, Yanaga, K., additional, Podesta, L., additional, Casavilla, A., additional, Wos, S., additional, Murray, J., additional, Oral, A., additional, D'andrea, P., additional, Banner, B., additional, and Starzl, T. E., additional

Published
1990
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42. The long-term followup of primary anterior cruciate ligament repair: defining a rationale for augmentation... including commentary by Feagin JA Jr.

Author

Sherman MF, Lieber L, Bonamo JR, Podesta L, and Reiter I

Abstract

Fifty primary ACL repairs using the Marshall multiple suture technique were analyzed. The average age at surgery was 23 years (range, 15 to 56), with 76% under the age of 30. The average followup was 61.3 months (range, 48 to 86). The average time from injury to surgery was 7 days (range, 1 to 18). Eighty percent of the injuries were sports-related with football and skiing predominating. Thirty-eight percent were 'isolated' ACL tears, and 62% had associated injuries. There was a 46% incidence of meniscal tear with 59% of the meniscal tears being repaired. The postoperative evaluation included a multifactorial analysis correlating 43 variables including subjective, objective, radiographic, and KT-1000 data. The Hospital for Special Surgery Knee Diagnostic Score, a clinical objective score based on the postoperative Lachman and pivot shift examination, a KT-1000 arthrometer data score, and an overall combined assessment score were determined. The results showed 59% excellent, 18% good, 14% fair, and 8% poor. The Lachman test was diagnostic in all cases. The quality of ACL tissue at repair was rated excellent or good in 62% of the cases. Four patterns of ACL tears were distinguished by the location of the tear. Football injury, younger age, increased preoperative pivot shift, midsubstance Type IV tear, and return of full motion correlated with poor postoperative results. Increasing age, tight jointedness, Type I tears, and a 5 degree flexion contracture correlated with good postoperative results. [ABSTRACT FROM AUTHOR]

Published
1991

44. Comparison of UW with other solutions for liver preservation in dogs

Author

Todo, S., Podesta, L., Ueda, Y., Imventarza, O., Casavilla, A., Oks, A., Okuda, K., Nalesnik, M., Venkataramanan, R., and Starzl, T. E.

Abstract

The efficacy of the University of Wisconsin (UW) solution was compared with conventional Euro‐Collins solution, as well as with 3 variants of a silica gel solution developed at the University of Minnesota (UM). Protection of the liver grafts with UW was superior after 24 hour preservation, although the results were inferior to those with immediate transplantation, as judged by animal survival, liver function tests, coagulation, and histopathologic parameters. The UM‐III solution allowed similar animal survival as with the UW solution. Lactobionate and raffinose that are contained in both the UW and UM‐III solutions were thought to be essential constituents for long‐term preservation of liver grafts. The study not only establishes, under controlled circumstances, the superiority of the UW solution, but it also provides insight about the reasons for its effectiveness as well as a caution against its over exploitation.

Published
1989
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45. Thermal Relay Using Microprocessors for Electrical Engine Protection

Author

Bartoletti, C., Podesta, L., Sacerdoti, G., Benedetti, A., Cecili, F., and Paggi, R.

Abstract

An analysis is made of a multiple process simulation performed by means of a microprocessor prototype relay appropriately configured to monitor the temperature of a power system. The relay uses a PC which simulates the operation of an alternator. The economic advantages and the reliability of the process simulation are discussed. With the aim of evaluating the utility of the simulation, the influence of the individual steps on the total time of the simulation session is analyzed. An economic function is presented which makes the analysis valid not only for any type of process simulation, but also for series production processes.

Published
1989
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46. Amelioration of Normothermic Canine Liver Ischemia With Prostacyclin

Author

Todo, S., Yokoi, H., Podesta, L., ChapChap, P., Pan, C., Okuda, K., Kamiyama, Y., Demetris, J., Makowka, L., Iwatsuki, S., and Starzl, T.E.

Subjects
Dogs, Liver, Ischemia, Animals, Epoprostenol, Article
Abstract

A model of hepatic ischemia was developed in dogs using a pump-driven splanchnic-to-jugular vein bypass during crossclamping of the portal triad. An LD50 was established with three hours of ischemia. PGI2 given for one hour before the ischemic insult ameliorated the ischemic injury and increased survival.

Published
1988

47. Orthotopic Liver Transplantation in Dogs Receiving FK-506

Author

Todo, S., Podesta, L., ChapChap, P., Kahn, D., Pan, C-E., Ueda, Y., Okuda, K., Imventarza, O., Casavilla, A., Demetris, A.J., Makowka, L., and Starzl, T.E.

Subjects
Graft Rejection, Dogs, Liver Function Tests, Pyridines, Body Weight, Drug Evaluation, Preclinical, Animals, Article, Immunosuppressive Agents, Tacrolimus, Liver Transplantation
Abstract

Ten dogs that survived the perioperative events of liver transplantation were treated with 1 mg/kg/d oral FK. Eight of the recipients lived for at least 1 month postoperatively, and seven are still alive with normal hepatic function after 35 to 65 days. The consistency and good quality of results with this difficult transplant preparation using FK, in spite of its rumored great toxicity in dogs, have highlighted the importance of further developing the drug.

Published
1987

48. Effect of FK506 in Experimental Organ Transplantation

Author

Todo, S., Murase, N., Ueda, Y., Podesta, L., ChapChap, P., Kahn, D., Okuda, K., Imventarza, O., Casavilla, A., Demetris, J., Makowka, L., and Starzl, T.E.

Subjects
Graft Rejection, Pyridines, Transplantation, Heterologous, Drug Evaluation, Preclinical, Cyclosporins, Kidney Transplantation, Article, Tacrolimus, Liver Transplantation, Rats, Rats, Inbred ACI, Dogs, Rats, Inbred Lew, Rats, Inbred BN, Animals, Heart Transplantation, Prednisone, Transplantation, Homologous, Drug Therapy, Combination, Kidney Diseases, Immunosuppressive Agents
Abstract

FK506 is the most potent immunosuppressive agent known. Its toxicity is substantial in dogs, minor in rats, and unknown in subhuman primates. In small doses that are nontoxic even in dogs, it can be used in synergistic combination with cyclosporine, steroids, and presumably in other drugs.

Published
1988

49. Bilateral simultaneous rupture of the infrapatellar tendon in a recreational athlete.

Author

Podesta L, Sherman MF, and Bonamo JR

Abstract

Bilateral rupture of the infrapatellar tendon is a very rare injury. The majority of reported cases of bilateral infrapatellar tendon rupture involve patients with chronic systemic diseases such as rheumatoid arthritis, systemic lupus erythematosus, chronic renal disease, and gout. Corticosteroid medication has also been implicated. Siwek and Rao, in their study of 33 patients, reported that 80% of isolated patellar tendon ruptures occurred in patients less than 40 years of age, with a higher incidence in the male population. The following is a case report of a bilateral simultaneous rupture of the infrapatellar tendons in a healthy adult recreational athlete. [ABSTRACT FROM AUTHOR]

Published
1991

50. Comparison of UW with other solutions for liver preservation in dogs

Author

Todo, S, Podesta, L, Ueda, Y, Imventarza, O, Cassavilla, A, Oks, A, Okuda, K, Nalesnik, M, Venkataramanan, R, Starzl, TE, Todo, S, Podesta, L, Ueda, Y, Imventarza, O, Cassavilla, A, Oks, A, Okuda, K, Nalesnik, M, Venkataramanan, R, and Starzl, TE

Abstract

The efficacy of the University of Wisconsin (UW) solution was compared with conventional Euro-Collins solution, as well as with 3 variants of a silica gel solution developed at the University of Minnesota (UM). Protection of the liver grafts with UW was superior after 24 hour preservation, although the results were inferior to those with immediate transplantation, as judged by animal survival, liver function tests, coagulation, and histopathologic parameters. The UM-III solution allowed similar animal survival as with the UW solution. Lactobionate and raffinose that are contained in both the UW and UM-III solutions were thought to be essential constituents for long-term preservation of liver grafts. The study not only establishes, under controlled circumstances, the superiority of the UW solution, but it also provides insight about the reasons for its effectiveness as well as a caution against its over exploitation.

Published
1989

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