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4. There's something in the air -- the role of volatile organic compounds in exhaled air in the diagnosis and treatment of asthma in children.

Author

Gmachowska, Katarzyna, Jarek, Aleksandra, Jerzyńska, Joanna, Majak, Paweł, and Podlecka, Daniela

Subjects
ASTHMA treatment, ASTHMA diagnosis, DISEASE exacerbation, SHORT-chain fatty acids, SPIROMETRY, RESPIRATION, HUMAN microbiota, GAS chromatography, AIR, ORGANIC compounds, CHLAMYDIALES, PHENOTYPES, CHILDREN
Abstract

Bronchial asthma, which is the most common chronic disease of the respiratory system, causes significant diagnostic problems in younger children due to the difficulty of performing typical respiratory function tests, including spirometry. This problem is especially important for paediatricians, allergists, and pulmonologists. A new, promising method of objectifying allergic inflammation in the respiratory tract is the measurement of volatile organic compounds (VOCs) in exhaled air. They are formed during the metabolic processes of the body's cells and the microorganisms that inhabit it. Clinical benefits of the VOC profile have been proven in differentiating asthma phenotypes, monitoring its course, predicting exacerbations, and responding to treatment. However, further studies are needed to standardise this process and establish reference standards. The aim of this study is to review the latest literature on the usefulness of VOC profiles in exhaled air and the composition of the microbiome in children with bronchial asthma. [ABSTRACT FROM AUTHOR]

Published
2024
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10. The Effect of Environmental Factors on Immunological Pathways of Asthma in Children of the Polish Mother and Child Cohort Study

Author

Żywiołowska-Smuga Sara, Jerzyńska Joanna, Podlecka Daniela, Polańska Kinga, and Brzozowska Agnieszka

Subjects
asthma, children, regulatory T cells, FOXP3, environmental factors, Health, Toxicology and Mutagenesis, Public Health, Environmental and Occupational Health
Abstract

The FOXP3 transcription factor is a marker of regulatory T cells (Tregs), and is essential in the process of their activation and proper expression by promoting immune homeostasis. To assess the influence of the environment on the development of asthma, we hypothesized that in our cohort, exposure to environmental factors is associated with asthma risk in children, and that FOXP3 levels vary with their incidence and are negatively correlated with developing asthma. This prospective study conducted in Poland uses a cohort of 85 children (42 with and 43 without asthma diagnosis) aged 9 to 12 years recruited for the Polish Mother and Child Cohort Study. We collected questionnaires and organized visits to assess patients’ clinical condition (skin prick tests, lung function assessments). Blood samples were taken to determine immune parameters. Breastfed children had lower risk of asthma. Asthma risk was higher in children who live in the city, with antibiotic course before the age of 2 and antibiotic therapy more than twice a year. Environmental factors were associated with childhood asthma. Breastfeeding, the coexistence of other allergic diseases, and the frequency of housekeeping affect FOXP3 levels, which are negatively correlated with the risk of asthma.

Published
2023
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12. Wpływ zanieczyszczeń środowiska - pyłu zawieszonego PM2,5, PM10, ozonu i dwutlenku azotu na rozwój astmy i alergii u dzieci w wieku przedszkolnym.

Author

Bobrowska-Korzeniowska, Monika, Jerzyńska, Joanna, Podlecka, Daniela, Polańska, Kinga, Gwardys, Mikołaj, Paciorek, Małgorzata, and Stelmach, Włodzimierz

Abstract

Copyright of Paediatrics & Family Medicine / Pediatria i Medycyna Rodzinna is the property of Medical Communications Sp. z o.o. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023
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14. Home Environment in Early-Life and Lifestyle Factors Associated with Asthma and Allergic Diseases among Inner-City Children from the REPRO_PL Birth Cohort

Author

Kapszewicz, Katarzyna, primary, Podlecka, Daniela, additional, Polańska, Kinga, additional, Stelmach, Iwona, additional, Majak, Pawel, additional, Majkowska-Wojciechowska, Barbara, additional, Tymoniuk, Bogusław, additional, Jerzyńska, Joanna, additional, and Brzozowska, Agnieszka, additional

Published
2022
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17. Maternal diet during pregnancy and risk of allergic diseases in children up to 7–9 years old from Polish Mother and Child Cohort study

Author

Brzozowska, Agnieszka, primary, Podlecka, Daniela, additional, Jankowska, Agnieszka, additional, Król, Anna, additional, Kaleta, Dorota, additional, Trafalska, Elżbieta, additional, Nowakowska-Świrta, Ewa, additional, Kałużny, Paweł, additional, Hanke, Wojciech, additional, Bal-Gierańczyk, Katarzyna, additional, Kowalska, Małgorzata, additional, Polańska, Kinga, additional, and Jerzyńska, Joanna, additional

Published
2022
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29. Wpływ regularnego treningu na czynność płuc u młodzieży.

Author

Malewska-Kaczmarek, Kamila, Jerzyńska, Joanna, Podlecka, Daniela, Mospinek, Ewa, Górska, Katarzyna, and Stelmach, Iwona

Subjects
EXPIRATORY flow, SPORTS for children, RESPIRATORY organs, SCHOOLBOYS, SCHOOL sports
Abstract

Copyright of Paediatrics & Family Medicine / Pediatria i Medycyna Rodzinna is the property of Medical Communications Sp. z o.o. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2019
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33. Wpływ leczenia kalcytriolem i cholekalcyferolem na gospodarkę wapniowo-fosforanową u pacjentów chorych na mukowiscydozę.

Author

Koniarek-Maniecka, Agnieszka, Olszowiec-Chlebna, Małgorzata, Podlecka, Daniela, Jerzyńska, Joanna, and Stelmach, Iwona

Subjects
FAT-soluble vitamins, PARATHYROID hormone, CALCITRIOL, CYSTIC fibrosis, BONE metabolism
Abstract

Copyright of Paediatrics & Family Medicine / Pediatria i Medycyna Rodzinna is the property of Medical Communications Sp. z o.o. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2019
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35. Ropień płuca u immunokompetentnej 4-letniej dziewczynki – opis przypadku.

Author

Podlecka, Daniela, Jach, Beata, Podsiadłowicz-Borzęcka, Małgorzata, and Stelmach, Iwona

Subjects
LUNG abscesses, IMMUNOCOMPETENT cells, PEDIATRICS, INTRAVENOUS injections, INTRAVENOUS therapy
Abstract

Copyright of Paediatrics & Family Medicine / Pediatria i Medycyna Rodzinna is the property of Medical Communications Sp. z o.o. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2017
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