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Introduction: In this review, the analysis of technologies for obtaining biologically active proteins from various sources is carried out, and the comparative analysis of technologies for creating producers of biologically active proteins is presented. Special attention is paid to genetically modified animals as bioreactors for the pharmaceutical industry of a new type. The necessity of improving the technology of development transgenic rabbit producers and creating a platform solution for the production of biological products is substantiated. The advantages of using TrB for the production of recombinant proteins: The main advantages of using TrB are the low cost of obtaining valuable complex therapeutic human proteins in readily accessible fluids, their greater safety relative to proteins isolated directly from human blood, and the greater safety of the activity of the native protein. The advantages of the mammary gland as a system for the expression of recombinant proteins: The mammary gland is the organ of choice for the expression of valuable recombinant proteins because milk is easy to collect in large volumes. Methods for obtaining transgenic animals: The modern understanding of the regulation of gene expression and the discovery of new tools for gene editing can increase the efficiency of creating bioreactors for animals and help to obtain high concentrations of the target protein. The advantages of using rabbits as bioreactors producing recombinant proteins in milk: The rabbit is a relatively small animal with a short duration of gestation, puberty and optimal size, capable of producing up to 5 liters of milk per year per female, receiving up to 300 grams of the target protein. [ABSTRACT FROM AUTHOR]

Purpose: to reveal the dynamics of regulatory and adaptive status in men after laparoscopic radical prostatectomy with a nerve-sparing result and when nerve-sparing did not result Material and methods. Observations have been performed on 50 patients with I-II degree prostate cancer with the prostatic gland volume of more than 40 cm3 before and after radical prostatectomy. In all patients observed by the method of V.M. Pokrovsky the functional test of cardio-respiratory synchronism on the «VNS-Micro» apparatus was carried out according to the computer program "System for determining cardio-respiratory synchronism in humans". The minimum and maximum frequency limits of the gating range, the gating range, and the duration of gating development at the minimum limit of the range were determined. According to the parameters of cardiorespiratory synchronism the index of regulatory adaptive status was calculated, and regulatory adaptive capabilities were found from it. Statistical analysis of the study results was carried out using the programs: «STATISTICA 10». Results. According to the index of regulatory adaptive status, after prostatectomy, patients were divided into individuals with good, satisfactory and low regulatory adaptive capabilities The index of regulatory adaptive status after radical prostatectomy did not change significantly in patients with good and satisfactory regulatory adaptive capabilities. In these 33 out of 50 patients, nervesparing was noted as a result of radical prostatectomy performed by laparoscopic access. In patients with low regulatory adaptive capabilities, the index of regulatory adaptive status decreased by 15.3% after radical prostatectomy. This was due to an increase in the duration of the development of gating at the minimum limit of the range by 65.4%, despite the increase in the range by 40.0%. In these 17 patients, as a result of radical prostatectomy with laparoscopic access, nerve-sparing did not occur. Conclusion. The parameters of cardio-respiratory synchronism, the index of regulatory adaptive status and regulatory adaptive capabilities reflect integratively the consequences of radical prostatectomy performed laparoscopically with a nerve-sparing result and when nerve-sparing does not result. [ABSTRACT FROM AUTHOR]