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1. International Association for the Study of Lung Cancer Study of Reproducibility in Assessment of Pathologic Response in Resected Lung Cancers After Neoadjuvant Therapy

Author

Dacic, Sanja, Travis, William, Redman, Mary, Saqi, Anjali, Cooper, Wendy A., Borczuk, Alain, Chung, Jin-Haeng, Glass, Carolyn, Lopez, Javier Martin, Roden, Anja C., Sholl, Lynette, Weissferdt, Annikka, Posadas, Juan, Walker, Angela, Zhu, Hu, Wijeratne, Manuja T., Connolly, Casey, Wynes, Murry, Bota-Rabassedas, Neus, Sanchez-Espiridion, Beatriz, Lee, J.Jack, Berezowska, Sabina, Chou, Teh-Ying, Kerr, Keith, Nicholson, Andrew, Poleri, Claudia, Schalper, Kurt A., Tsao, Ming-Sound, Carbone, David P., Ready, Neal, Cascone, Tina, Heymach, John, Sepesi, Boris, Shu, Catherine, Rizvi, Naiyer, Sonett, Josuha, Altorki, Nasser, Provencio, Mariano, Bunn, Paul A., Jr., Kris, Mark G., Belani, Chandra P., Kelly, Karen, and Wistuba, Ignacio

Published
2023
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2. The International Association for the Study of Lung Cancer Global Survey on Programmed Death-Ligand 1 Testing for NSCLC

Author

Mino-Kenudson, Mari, Le Stang, Nolwenn, Daigneault, Jillian B., Nicholson, Andrew G., Cooper, Wendy A., Roden, Anja C., Moreira, Andre L., Thunnissen, Erik, Papotti, Mauro, Pelosi, Giuseppe, Motoi, Noriko, Poleri, Claudia, Brambilla, Elisabeth, Redman, Mary, Jain, Deepali, Dacic, Sanja, Yatabe, Yasushi, Tsao, Ming Sound, Lopez-Rios, Fernando, Botling, Johan, Chen, Gang, Chou, Teh-Ying, Hirsch, Fred R., Beasley, Mary Beth, Borczuk, Alain, Bubendorf, Lukas, Chung, Jin-Haeng, Hwang, David, Lin, Dongmei, Longshore, John, Noguchi, Masayuki, Rekhtman, Natasha, Sholl, Lynette, Travis, William, Yoshida, Akihiko, Wynes, Murry W., Wistuba, Ignacio I., Kerr, Keith M., and Lantuejoul, Sylvie

Published
2021
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3. A Grading System for Invasive Pulmonary Adenocarcinoma: A Proposal From the International Association for the Study of Lung Cancer Pathology Committee

Author

Moreira, Andre L., Ocampo, Paolo S.S., Xia, Yuhe, Zhong, Hua, Russell, Prudence A., Minami, Yuko, Cooper, Wendy A., Yoshida, Akihiko, Bubendorf, Lukas, Papotti, Mauro, Pelosi, Giuseppe, Lopez-Rios, Fernando, Kunitoki, Keiko, Ferrari-Light, Dana, Sholl, Lynette M., Beasley, Mary Beth, Borczuk, Alain, Botling, Johan, Brambilla, Elisabeth, Chen, Gang, Chou, Teh-Ying, Chung, Jin-Haeng, Dacic, Sanja, Jain, Deepali, Hirsch, Fred R., Hwang, David, Lantuejoul, Sylvie, Lin, Dongmei, Longshore, John W., Motoi, Noriko, Noguchi, Masayuki, Poleri, Claudia, Rekhtman, Natasha, Tsao, Ming-Sound, Thunnissen, Erik, Travis, William D., Yatabe, Yasushi, Roden, Anja C., Daigneault, Jillian B., Wistuba, Ignacio I., Kerr, Keith M., Pass, Harvey, Nicholson, Andrew G., and Mino-Kenudson, Mari

Published
2020
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4. The Promises and Challenges of Tumor Mutation Burden as an Immunotherapy Biomarker: A Perspective from the International Association for the Study of Lung Cancer Pathology Committee

Author

Sholl, Lynette M., Hirsch, Fred R., Hwang, David, Botling, Johan, Lopez-Rios, Fernando, Bubendorf, Lukas, Mino-Kenudson, Mari, Roden, Anja C., Beasley, Mary Beth, Borczuk, Alain, Brambilla, Elisabeth, Chen, Gang, Chou, Teh-Ying, Chung, Jin-Haeng, Cooper, Wendy A., Dacic, Sanja, Lantuejoul, Sylvie, Jain, Deepali, Lin, Dongmei, Minami, Yuko, Moreira, Andre, Nicholson, Andrew G., Noguchi, Masayuki, Papotti, Mauro, Pelosi, Giuseppe, Poleri, Claudia, Rekhtman, Natasha, Tsao, Ming-Sound, Thunnissen, Erik, Travis, William, Yatabe, Yasushi, Yoshida, Akihiko, Daigneault, Jillian B., Zehir, Ahmet, Peters, Solange, Wistuba, Ignacio I., Kerr, Keith M., and Longshore, John W.

Published
2020
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5. IASLC Multidisciplinary Recommendations for Pathologic Assessment of Lung Cancer Resection Specimens After Neoadjuvant Therapy

Author

Travis, William D., Dacic, Sanja, Wistuba, Ignacio, Sholl, Lynette, Adusumilli, Prasad, Bubendorf, Lukas, Bunn, Paul, Cascone, Tina, Chaft, Jamie, Chen, Gang, Chou, Teh-Ying, Cooper, Wendy, Erasmus, Jeremy J., Ferreira, Carlos Gil, Goo, Jin-Mo, Heymach, John, Hirsch, Fred R., Horinouchi, Hidehito, Kerr, Keith, Kris, Mark, Jain, Deepali, Kim, Young T., Lopez-Rios, Fernando, Lu, Shun, Mitsudomi, Tetsuya, Moreira, Andre, Motoi, Noriko, Nicholson, Andrew G., Oliveira, Ricardo, Papotti, Mauro, Pastorino, Ugo, Paz-Ares, Luis, Pelosi, Giuseppe, Poleri, Claudia, Provencio, Mariano, Roden, Anja C., Scagliotti, Giorgio, Swisher, Stephen G., Thunnissen, Erik, Tsao, Ming S., Vansteenkiste, Johan, Weder, Walter, and Yatabe, Yasushi

Published
2020
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6. PD-L1 Testing for Lung Cancer in 2019: Perspective From the IASLC Pathology Committee

Author

Lantuejoul, Sylvie, Sound-Tsao, Ming, Cooper, Wendy A., Girard, Nicolas, Hirsch, Fred R., Roden, Anja C., Lopez-Rios, Fernando, Jain, Deepali, Chou, Teh-Ying, Motoi, Noriko, Kerr, Keith M., Yatabe, Yasushi, Brambilla, Elisabeth, Longshore, John, Papotti, Mauro, Sholl, Lynette M., Thunnissen, Erik, Rekhtman, Natasha, Borczuk, Alain, Bubendorf, Lukas, Minami, Yuko, Beasley, Mary Beth, Botling, Johan, Chen, Gang, Chung, Jin-Haeng, Dacic, Sanja, Hwang, David, Lin, Dongmei, Moreira, Andre, Nicholson, Andrew G., Noguchi, Masayuki, Pelosi, Giuseppe, Poleri, Claudia, Travis, William, Yoshida, Akihiko, Daigneault, Jillian B., Wistuba, Ignacio I., and Mino-Kenudson, Mari

Published
2020
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7. Defining Morphologic Features of Invasion in Pulmonary Nonmucinous Adenocarcinoma With Lepidic Growth

Author

Thunnissen, Erik, Beasley, Mary Beth, Borczuk, Alain, Dacic, Sanja, Kerr, Keith M., Lissenberg-Witte, Birgit, Minami, Yuko, Nicholson, Andrew G., Noguchi, Masayuki, Sholl, Lynette, Tsao, Ming-Sound, Le Quesne, John, Roden, Anja C., Chung, Jin-Haeng, Yoshida, Akihiko, Moreira, Andre L., Lantuejoul, Sylvie, Pelosi, Giuseppe, Poleri, Claudia, Hwang, David, Jain, Deepali, Travis, William D., Brambilla, Elisabeth, Chen, Gang, Botling, Johan, Bubendorf, Lukas, Mino-Kenudson, Mari, Motoi, Noriko, Chou, Teh Ying, Papotti, Mauro, Yatabe, Yasushi, Cooper, Wendy, Group, Invasion Working, Epidemiology and Data Science, and APH - Methodology

Subjects
Pulmonary and Respiratory Medicine, Cancer och onkologi, Invasion, Oncology, Cancer and Oncology, Adenocarcinoma, Reproducibility, Extensive epithelial proliferation
Abstract

Introduction: Since the eight edition of the Union for In-ternational Cancer Control and American Joint Committee on Cancer TNM classification system, the primary tumor pT stage is determined on the basis of presence and size of the invasive components. The aim of this study was to identify histologic features in tumors with lepidic growth pattern which may be used to establish criteria for distinguishing invasive from noninvasive areas.Methods: A Delphi approach was used with two rounds of blinded anonymized analysis of resected nonmucinous lung adenocarcinoma cases with presumed invasive and nonin-vasive components, followed by one round of reviewer de-anonymized and unblinded review of cases with known outcomes. A digital pathology platform was used for measuring total tumor size and invasive tumor size. Results: The mean coefficient of variation for measuring total tumor size and tumor invasive size was 6.9% (range: 1.7%-22.3%) and 54% (range: 14.7%-155%), respectively, with substantial variations in interpretation of the size and location of invasion among pathologists. Following the presentation of the results and further discussion among members at large of the International Association for the Study of Lung Cancer Pathology Committee, extensive epithelial proliferation (EEP) in areas of collapsed lepidic growth pattern is recognized as a feature likely to be associated with invasive growth. The EEP is characterized by multilayered luminal epithelial cell growth, usually with high-grade cytologic features in several alveolar spaces.Conclusions: Collapsed alveoli and transition zones with EEP were identified by the Delphi process as morphologic features that were a source of interobserver variability. Definition criteria for collapse and EEP are proposed to improve reproducibility of invasion measurement.(c) 2022 International Association for the Study of Lung Cancer.

Published
2023

8. Best Practices Recommendations for Diagnostic Immunohistochemistry in Lung Cancer

Author

Yatabe, Yasushi, Dacic, Sanja, Borczuk, Alain C., Warth, Arne, Russell, Prudence A., Lantuejoul, Sylvie, Beasley, Mary Beth, Thunnissen, Erik, Pelosi, Giuseppe, Rekhtman, Natasha, Bubendorf, Lukas, Mino-Kenudson, Mari, Yoshida, Akihiko, Geisinger, Kim R., Noguchi, Masayuki, Chirieac, Lucian R., Bolting, Johan, Chung, Jin-Haeng, Chou, Teh-Ying, Chen, Gang, Poleri, Claudia, Lopez-Rios, Fernando, Papotti, Mauro, Sholl, Lynette M., Roden, Anja C., Travis, William D., Hirsch, Fred R., Kerr, Keith M., Tsao, Ming-Sound, Nicholson, Andrew G., Wistuba, Ignacio, and Moreira, Andre L.

Published
2019
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9. Interobserver Variation among Pathologists and Refinement of Criteria in Distinguishing Separate Primary Tumors from Intrapulmonary Metastases in Lung

Author

Nicholson, Andrew G., Torkko, Kathleen, Viola, Patrizia, Duhig, Edwina, Geisinger, Kim, Borczuk, Alain C., Hiroshima, Kenzo, Tsao, Ming S., Warth, Arne, Lantuejoul, Sylvie, Russell, Prudence A., Thunnissen, Erik, Marchevsky, Alberto, Mino-Kenudson, Mari, Beasley, Mary Beth, Botling, Johan, Dacic, Sanja, Yatabe, Yasushi, Noguchi, Masayuki, Travis, William D., Kerr, Keith, Hirsch, Fred R., Chirieac, Lucian R., Wistuba, Ignacio I., Moreira, Andre, Chung, Jin-Haeng, Chou, Teh Ying, Bubendorf, Lukas, Chen, Gang, Pelosi, Giuseppe, Poleri, Claudia, Detterbeck, Frank C., and Franklin, Wilbur A.

Published
2018
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10. The Use of Immunohistochemistry Improves the Diagnosis of Small Cell Lung Cancer and Its Differential Diagnosis. An International Reproducibility Study in a Demanding Set of Cases

Author

Thunnissen, Erik, Borczuk, Alain C., Flieder, Douglas B., Witte, Birgit, Beasley, Mary Beth, Chung, Jin-Haeng, Dacic, Sanja, Lantuejoul, Sylvie, Russell, Prudence A., den Bakker, Michael, Botling, Johan, Brambilla, Elisabeth, de Cuba, Erienne, Geisinger, Kim R., Hiroshima, Kenzo, Marchevsky, Alberto M., Minami, Yuko, Moreira, Andre, Nicholson, Andrew G., Yoshida, Akihiko, Tsao, Ming-Sound, Warth, Arne, Duhig, Edwina, Chen, Gang, Matsuno, Yoshihiro, Travis, William D., Butnor, Kelly, Cooper, Wendy, Mino-Kenudson, Mari, Motoi, Noriko, Poleri, Claudia, Pelosi, Giuseppe, Kerr, Keith, Aisner, Seena C., Ishikawa, Yuichi, Buettner, Reinhard H., Keino, Naoto, Yatabe, Yasushi, and Noguchi, Masayuki

Published
2017
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11. Estudio multicéntrico de características histopatológicas e inmunohistoquímicas del mesotelioma pleural difuso

Author

Poleri, Claudia, Acosta Haab, Gabriela, Falcoff, Nora, Guman, Gabriela, Dalurzo, Liliana, Iotti, Alejandro, Martín, María Eugenia, Olmedo, Gloria, Rayá, Mercedes, Reginatto, Atilio, Werbach, Andrea, Demelli, Gabriela, Labanca, María José, Leguina, Laura, and Mora, María Florencia

Subjects
Mesotelioma pleural, Grading mesothelioma, Pathology, Patología, Grados de mesotelioma, Pleural mesothelioma
Abstract

The pathological diagnosis of diffuse pleural mesothelioma (DPM) contributes to treatment selection and clinical trials interpretation. To know its characteristics and evaluate the viability of comprehensive pathological diagnosis of DPM in Argentina we did a retrospective descriptive study of DPM cases reported from 2009 to 2018. We analyzed 398 cases corresponding to 238 (60%) men and 160 (40%) women, median age 66 years, from surgical biopsies (78%), small biopsies (16.5%) and surgical resections (5.5%). The 77% were epithelioid (E-DPM), 12% biphasic, 10% sarcomatoid, and 4 cases transitional variant. In E-DPM the main pattern was tubular in 36% and solid in 33%. There was a second pattern in 179 cases. Considering the main pattern and the second together, 48% presented tubular subtype and 48% solid subtype. Stroma, necrosis, and nuclear score showed significant differences between E-DPM and non-epithelioid mesotheliomas. Overall tumor grade was predominantly low in E-DPM, except for 42% of the solid main pattern. We recognized the transitional variant extensively in 4 cases and focally in 8. The immunohistochemical antibody panel used included pan-cytokeratin, calretinin, WT-1, cytokeratin 5, CEA and TTF-1. The expression of cytokeratin 5, calretinin and WT-1 was lower in the sarcomatoid type (43%, 87 and 37%) than in the epithelioid type (92%, 98% and 93%). This study highlights the tumor heterogeneity of DPM that shows the diagnostic difficulty, and the feasibility of evaluating histological aggressiveness in E-DPM, B-DPM and S-DPM in our country. Resumen El diagnóstico patológico del mesotelioma pleural difuso (MPD) contribuye a la selección del tratamiento y a la interpretación de los ensayos clínicos. Para conocer sus características y evaluar la viabilidad del diagnóstico patológico de MPD en Argentina se realizó un estudio descriptivo retros pectivo de los casos de MPD informados de 2009 a 2018. Se analizaron 398 casos correspondientes a 238 (60%) hombres y 160 (40%) mujeres, mediana de edad de 66 años, a partir de biopsias quirúrgicas (78%), biopsias pequeñas (16.5%) y resecciones quirúrgicas (5.5%). El 77% fue epitelioide (E-MPD), 12% bifásicos, 10% sarcomatoides y 4 casos variante transicional. En E-MPD se encontró como patrón principal el tubular en 36% y el sólido en 33%. Hubo un segundo patrón en 179 casos. Considerando el principal y el segundo patrón en conjunto, el 48% presentó subtipo tubular y el 48% subtipo sólido. El estroma, la necrosis y el score nuclear mostraron diferencias significativas entre E-MPD y mesoteliomas no epitelioides. El grado general del tumor fue predominantemente bajo en E-MPD, a excepción del 42% del patrón principal sólido. Reconocimos la variante transicional en forma extensa en 4 casos y focalmente en 8. La expresión de citoqueratina 5, calretinina y WT-1 fue menor en el tipo sarcomatoide (43%, 87 y 37%) que en el tipo epitelioide (92%, 98% y 93%). Este estudio destaca la heterogeneidad tumoral de MPD que evidencia la dificu ltad en el diagnóstico y la viabilidad de evaluar la agresividad histológica en E-MPD, B-MPD y S-MPD en nuestro país.

Published
2022

12. NSCLC Subtyping in Conventional Cytology: Results of the International Association for the Study of Lung Cancer Cytology Working Group Survey to Determine Specific Cytomorphologic Criteria for Adenocarcinoma and Squamous Cell Carcinoma

Author

Jain, Deepali, primary, Nambirajan, Aruna, additional, Chen, Gang, additional, Geisinger, Kim, additional, Hiroshima, Kenzo, additional, Layfield, Lester, additional, Minami, Yuko, additional, Moreira, Andre L., additional, Motoi, Noriko, additional, Papotti, Mauro, additional, Rekhtman, Natasha, additional, Russell, Prudence A., additional, Prince, Spasenija Savic, additional, Schmitt, Fernando, additional, Yatabe, Yasushi, additional, Eppenberger-Castori, Serenella, additional, Bubendorf, Lukas, additional, Beasley, Mary Beth, additional, Berezowska, Sabina, additional, Borczuk, Alain, additional, Brambilla, Elizabeth, additional, Chou, Teh-Ying, additional, Chung, Jin-Haeng, additional, Cooper, Wendy, additional, Dacic, Sanja, additional, Chan, Yuchen, additional, Hirsch, Fred R., additional, Hwang, David, additional, Joubert, Philippe, additional, Kerr, Keith, additional, Lantuejoul, Sylvie, additional, Lin, Dongmei, additional, Lopez-Rios, Fernando, additional, Matsubara, Daisuke, additional, Mino-Kenudson, Mari, additional, Nicholson, Andrew, additional, Poleri, Claudia, additional, Roden, Anja, additional, Schalper, Kurt, additional, Sholl, Lynette, additional, Thunnissen, Erik, additional, Travis, William D., additional, Tsao, Ming, additional, and Wistuba, Ignacio, additional

Published
2022
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18. MULTICENTER STUDY OF DIFFUSE PLEURAL MESOTHELIOMA. HISTOPATHOLOGICAL AND IMMUNOHISTOCHEMICAL FEATURES.

Author

POLERI, CLAUDIA, ACOSTA HAAB, GABRIELA, FALCOFF, NORA, GUMAN, GABRIELA, DALURZO, LILIANA, IOTTI, ALEJANDRO, EUGENIA MARTÍN, MARÍA, OLMEDO, GLORIA, RAYÁ, MERCEDES, REGINATTO, ATILIO, WERBACH, ANDREA, DEMELL, GABRIELA, JOSÉ LABANCA, MARÍA, LEGUINA, LAURA, and FLORENCIA MORA, MARÍA

Abstract

Copyright of Medicina (Buenos Aires) is the property of Medicina (Buenos Aires) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2022

21. Eighth edition staging of thoracic malignancies : Implications for the reporting pathologist

Author

Nicholson, Andrew G., Tsao, Ming S., Travis, William D., Patil, Deepa T., Galateau-Salle, Francoise, Marino, Mirella, Dacic, Sanja, Beasley, Mary Beth, Butnor, Kelly J., Yatabe, Yasushi, Pass, Harvey I., Rusch, Valerie W., Detterbeck, Frank C., Asamura, Hisao, Rice, Thomas W., Rami-Porta, Ramon, Goldstraw, Peter, Ball, David, Beer, David, Beyruti, Ricardo, Bolejack, Vanessa, Chansky, Kari, Crowley, John, Eberhardt, Wilfried, Edwards, John, Giroux, Dorothy, Gleeson, Fergus, Groome, Patti, Huang, James, Kennedy, Catherine, Kim, Jhingook, Kim, Young Tae, Kingsbury, Laura, Kondo, Haruhiko, Krasnik, Mark, Kubota, Kaoru, Lerut, Toni, Lyons, Gustavo, Marom, Edith M., Van Meerbeeck, Jan, Mitchell, Alan, Nakano, Takashi, Nowak, Anna, Peake, Michael, Rosenzweig, Kenneth, Ruffini, Enrico, Saijo, Nagahiro, Van Schil, Paul, Sculier, Jean-Paul, Shemanski, Lynn, Stratton, Kelly, Suzuki, Kenji, Tachimori, Yuji, Thomas, Charles F., Turrisi, Andrew, Vansteenkiste, Johan, Watanabe, Hirokazu, Wu, Yi-Long, Bankier, Alex, Flieder, Douglas B., Goo, Jin Mo, MacMahon, Heber, Naidich, David, Powell, Charles A., Prokop, Mathias, Arenberg, Douglas A., Donington, Jessica S., Franklin, Wilbur A., Girard, Nicolas, Mazzone, Peter J., Tanoue, Lynn T., Baas, Paul, Erasmus, Jeremy, Hasegawa, Seiki, Inai, Kouki, Kernstine, Kemp, Kindler, Hedy, Krug, Lee, Nackaerts, Kristiaan, Rice, David, Falkson, Conrad, Filosso, Pier Luigi, Giaccone, Giuseppe, Kondo, Kazuya, Lucchi, Marco, Okumura, Meinoshin, Blackstone, Eugene, Geisinger, Kim, Borczuk, Alain, Warth, Arne, Lantuejoul, Sylvie, Russell, Prudence, Thunnissen, Erik, Marchevsky, Alberto, Mino-Kenudson, Mari, Botling, Johan, Noguchi, Masayuki, Kerr, Keith, Hirsch, Fred R., Chirieac, Lucian, Wistuba, Ignacio I., Moreira, Andre, Chung, Jin-Haeng, Chou, Teh Ying, Bubendorf, Lukas, Chen, Gang, Pelosi, Giuseppe, and Poleri, Claudia

Subjects
medicine.medical_specialty, business.industry, General surgery, education, Medizin, Context (language use), General Medicine, Thoracic Neoplasms, medicine.disease, Pathology and Forensic Medicine, 03 medical and health sciences, Medical Laboratory Technology, 0302 clinical medicine, 030220 oncology & carcinogenesis, Interest group, medicine, Humans, 030211 gastroenterology & hepatology, Mesothelioma, Lung cancer, business, Neoplasm Staging
Abstract

Context The Staging and Prognostic Factors Committee of the International Association for the Study of Lung Cancer, in conjunction with the International Mesothelioma Interest Group, the International Thymic Malignancy Interest Group, and the Worldwide Esophageal Cancer Collaboration, developed proposals for the 8th edition of their respective tumor, node, metastasis (TNM) staging classification systems. Objective To review these changes and discuss issues for the reporting pathologist. Data Sources Proposals were based on international databases of lung (N = 94 708), with an external validation using the US National Cancer Database; mesothelioma (N = 3519); thymic epithelial tumors (10 808); and epithelial cancers of the esophagus and esophagogastric junction (N = 22 654). Conclusions These proposals have been mostly accepted by the Union for International Cancer Control and the American Joint Committee on Cancer and incorporated into their respective staging manuals (2017). The Union for International Cancer Control recommended implementation beginning in January 2017; however, the American Joint Committee on Cancer has deferred deployment of the eighth TNM until January 1, 2018, to ensure appropriate infrastructure for data collection. This manuscript summarizes the updated staging of thoracic malignancies, specifically highlighting changes from the 7th edition that are relevant to pathologic staging. Histopathologists should become familiar with, and start to incorporate, the 8th edition staging in their daily reporting of thoracic cancers henceforth.

Published
2018

22. PD-L1 Immunohistochemistry Comparability Study in Real-Life Clinical Samples: Results of Blueprint Phase 2 Project

Author

Tsao, Ming Sound, primary, Kerr, Keith M., additional, Kockx, Mark, additional, Beasley, Mary-Beth, additional, Borczuk, Alain C., additional, Botling, Johan, additional, Bubendorf, Lukas, additional, Chirieac, Lucian, additional, Chen, Gang, additional, Chou, Teh-Ying, additional, Chung, Jin-Haeng, additional, Dacic, Sanja, additional, Lantuejoul, Sylvie, additional, Mino-Kenudson, Mari, additional, Moreira, Andre L., additional, Nicholson, Andrew G., additional, Noguchi, Masayuki, additional, Pelosi, Giuseppe, additional, Poleri, Claudia, additional, Russell, Prudence A., additional, Sauter, Jennifer, additional, Thunnissen, Erik, additional, Wistuba, Ignacio, additional, Yu, Hui, additional, Wynes, Murry W., additional, Pintilie, Melania, additional, Yatabe, Yasushi, additional, and Hirsch, Fred R., additional

Published
2018
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23. P3.01-021 Reproducibility of Comprehensive Histologic Assessment and Refining Histologic Criteria in P Staging of Multiple Tumor Nodules

Author

Nicholson, Andrew, primary, Viola, Patrizia, additional, Torkko, Kathleen, additional, Duhig, Edwina, additional, Geisinger, Kim, additional, Borczuk, Alain, additional, Hiroshima, Kenzo, additional, Tsao, Ming, additional, Warth, Arne, additional, Lantuejoul, Sylvie, additional, Russell, Prudence, additional, Thunnissen, Erik, additional, Marchevsky, Alberto, additional, Mino-Kenudson, Mari, additional, Beasley, Mary Beth, additional, Botling, Johan, additional, Dacic, Sanja, additional, Yatabe, Yasushi, additional, Noguchi, Masayuki, additional, Travis, William, additional, Kerr, Keith, additional, Hirsch, Fred R., additional, Chirieac, Lucian, additional, Wistuba, Ignacio, additional, Moreira, Andre, additional, Chung, Jin-Haeng, additional, Chou, Teh Ying, additional, Bubendorf, Lukas, additional, Chen, Gang, additional, Pelosi, Giuseppe, additional, Poleri, Claudia, additional, and Franklin, Wilbur, additional

Published
2017
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24. Observational study of patients with gastroenteropancreatic and bronchial neuroendocrine tumors in Argentina: Results from the large database of a multidisciplinary group clinical multicenter study

Author

O’CONNOR, JUAN MANUEL, primary, MARMISSOLLE, FABIANA, additional, BESTANI, CLAUDIA, additional, PESCE, VERONICA, additional, BELLI, SUSANA, additional, DOMINICHINI, ENZO, additional, MENDEZ, GUILLERMO, additional, PRICE, PAOLA, additional, GIACOMI, NORA, additional, PAIROLA, ALEJANDRO, additional, LORIA, FERNANDO SÁNCHEZ, additional, HUERTAS, EDUARDO, additional, MARTIN, CLAUDIO, additional, PATANE, KARINA, additional, POLERI, CLAUDIA, additional, ROSENBERG, MOISES, additional, CABANNE, ANA, additional, KUJARUK, MIRTA, additional, CAINO, ANALIA, additional, ZAMORA, VICTOR, additional, MARIANI, JAVIER, additional, DIOCA, MARIANO, additional, PARMA, PATRICIA, additional, PODESTA, GUSTAVO, additional, ANDRIANI, OSCAR, additional, GONDOLESI, GABRIEL, additional, and ROCA, ENRIQUE, additional

Published
2014
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27. TUMORES CARCINOIDES PULMONARES TRATADOS QUIRÚRGICAMENTE VALOR PRONÓSTICO DE LA 7a ESTADIFICACIÓN TNM.

Author

PATANÉ, ANA K., POLERI, CLAUDIA, MARTÍN, CLAUDIO, PUPARELI, CARMEN, ROSALES, ADOLFO, RIVERO, HÉCTOR, ROJAS, OSCAR, and ROSENBERG, MOISÉS

Abstract

Copyright of Medicina (Buenos Aires) is the property of Medicina (Buenos Aires) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2014

29. Defining morphologic features of invasion in pulmonary non-mucinous adenocarcinoma with lepidic growth -A proposal by the IASLC Pathology Committee

Author

Thunnissen, Erik, Beasley, Mary Beth, Borczuk, Alain, Dacic, Sanja, Kerr, Keith M., Minami, Yuko, Nicholson, Andrew G., Sholl, Lynette, Tsao, Ming-Sound, Noguchi, Masayuki, Lissenberg-Witte, Birgit, Le Quesne, John, Roden, Anja C., Chung, Jin-Haeng, Yoshida, Akihiko, Moreira, Andre L., Lantuejoul, Sylvie, Pelosi, Giuseppe, Poleri, Claudia, Hwang, David, Jain, Deepali, Travis, William D., Brambilla, Elisabeth, Chen, Gang, Botling, Johan, Bubendorf, Lukas, Mino-Kenudson, Mari, Motoi, Noriko, Chou, Teh Ying, Papotti, Mauro, Yatabe, Yasushi, and Cooper, Wendy

Abstract

Since the 8thedition of UICC/AJCC TNM classification system the primary tumor pT stage is determined based on presence and size of the invasive components. The aim of this study was to identify histological features in tumors with lepidic growth pattern that may be used to establish criteria for distinguishing invasive from non-invasive areas.

Published
2022
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31. Observational study of patients with gastroenteropancreatic and bronchial neuroendocrine tumors in Argentina: Results from the large database of a multidisciplinary group clinical multicenter study.

Author

O'Connor JM, Marmissolle F, Bestani C, Pesce V, Belli S, Dominichini E, Mendez G, Price P, Giacomi N, Pairola A, Loria FS, Huertas E, Martin C, Patane K, Poleri C, Rosenberg M, Cabanne A, Kujaruk M, Caino A, Zamora V, Mariani J, Dioca M, Parma P, Podesta G, Andriani O, Gondolesi G, and Roca E

Abstract

Neuroendocrine tumors (NET) include a spectrum of malignancies arising from neuroendocrine cells throughout the body. The objective of this clinical investigation of retrospectively and prospectively collected data was to describe the prevalence, demographic data, clinical symptoms and methods of diagnosis of NET and the treatment and long-term follow-up of patients with NET. Data were provided by the participating centers and assessed for consistency by internal reviewers. All the cases were centrally evaluated (when necessary) by the pathologists in our group. The tissue samples were reviewed by hematoxylin and eosin and immunohistochemical staining techniques to confirm the diagnosis of NET. In total, 532 cases were documented: 461 gastroenteropancreatic-NET (GEP-NET) and 71 bronchial NET (BNET). All the tumors were immunohistochemically defined according to the World Health Organization (WHO) and European Neuroendocrine Tumor Society criteria. The most common initial symptoms in GEP-NET were abdominal pain, diarrhea, bowel obstruction, flushing, gastrointestinal bleeding and weight loss. The most common tumor types were carcinoid (58.0%), non-functional pancreatic tumor (23.0%), metastatic NET of unknown primary (16.0%) and functional pancreatic tumor (3.0%). Of the BNET, 89.0% were typical and 11.0% atypical carcinoids. Of the patients with GEP-NET, 59.2% had distant metastasis at diagnosis. The locations of the primary tumors in GEP-NET were the small bowel (26.9%), pancreas (25.2%), colon-rectum (12.4%), appendix (7.6%), stomach (6.9%), esophagus (2.8%), duodenum (2.0%) and unknown primary (16.3%). The histological subtypes based on the WHO classification were well-differentiated NET (20.1%), well-differentiated neuroendocrine carcinomas (66.5%) and poorly differentiated neuroendocrine carcinomas (10.3%). Overall, 67.3% of the patients underwent surgery, 41.2% with curative intent and 26.1% for palliative purposes. The 5-year survival rates were 65.1% (95% confidence interval, 58.0-71.4%) in GEP-NET and 100.0% in typical carcinoid of the lung. This observational, non-interventional, longitudinal study aimed to accumulate relevant information regarding the epidemiology, clinical presentation and current practices in the treatment of NET patients in Argentina, providing insight into regional differences and patterns of care in this heterogeneous disease.

Published
2014
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32. [Surgically treated bronchopulmonary carcinoid tumours. Prognostic value of TNM staging 7a edition].

Author

Patané AK, Poleri C, Martín C, Pupareli C, Rosales A, Rivero H, Rojas O, and Rosenberg M

Subjects
Adolescent, Adult, Aged, Bronchial Neoplasms surgery, Carcinoid Tumor surgery, Disease-Free Survival, Female, Humans, Lung Neoplasms surgery, Male, Middle Aged, Prognosis, Recurrence, Young Adult, Bronchial Neoplasms pathology, Carcinoid Tumor pathology, Lung Neoplasms pathology, Neoplasm Staging
Abstract

We analyzed 43 women (61%) and 28 men (39%) surgically treated for carcinoid tumors from Jan/1975 to Dec/2011. Median age: 38 years (13-67). Typical carcinoid (TC) appeared in 63 (89%) patients, 8 (11%) suffered from atypical carcinoid (AC). Median follow-up: 4 years (1-24). TC stages were: IA = 33 (52%), IB = 10 (16%), IIA = 2 (3%), IIB = 2 (3%), IIIA = 12 (19%) and IIIB = 2 (3%); AC stages were: IA = 1 (12.5%), IIB = 1 (12.5%), IIIA = 2 (25%) and IIIB = 4 (50%). TNM classification did not show significant differences on 5-years survival period by stage (p = 0.689), even according to histological type (TC: p = 0.547; AC: p = 0.592). The disease-free survival rate was significantly lower (TC: 3 years vs. AC: 2 years, p = 0.000) and relapses were more frequent in AC (AC: 50% vs. TC: 2%, p = 0.000). The 7th TNM staging was not influential in estimating survival from carcinoid tumours in our population. The histological subtype was a better prognostic factor.

Published
2014

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