Search

Your search keyword '"Poletaeva, I. I."' showing total 275 results
Start Over Author "Poletaeva, I. I."
275 results on '"Poletaeva, I. I."'

18. The Complex System of the Mouse Brain: Selection for Successful Solution of a Cognitive Test.

Author

Poletaeva, I. I., Perepelkina, O. V., and Zorina, Z. A.

Abstract

This study provides a review of experimental research on selection in mice, which yielded positive results. The selection of mice was high (the task required mice to understand that an object that has become invisible still exists and can be found) and poor performance occurred in a cognitive test. The results we obtained revealed better short term memory in mice selected for high performance scores and that these mice also had higher performance in tests for novelty and attention. This suggests that differences between the mice used in the experiment are associated not only with cognitive abilities in tests, but also with more pronounced "executive functions." [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

23. The Role of Brain Monoamines in the Formation of Audiogenic Myoclonic Seizures in Krushinsky–Molodkina Rats.

Author

Litvinova, S. A., Voronina, T. A., Kudrin, V. S., Narkevich, V. B., Surina, N. M., Poletaeva, I. I., and Fedotova, I. B.

Abstract

Abstract—Experiments were carried out on rats of the Krushinsky–Molodkina (KM) strain without sound stimulation (KM-baseline group) and after the development of audiogenic kindling (AuK) in them (KM-AuK group). The control group was rats of the "0" strain, in which convulsions in response to sound were completely absent. AuK was generated using 20 repeated sound stimulation (120 dB). Neurochemical analysis was performed by HPLC/ED in the frontal cortex, hippocampus, hypothalamus, striatum, nucleus accumbens, and brainstem. It was shown that in KM rats AuK leads to the appearance of myoclonic seizures and a decrease in the intensity of generalized convulsive seizures, which is accompanied by a change in the functional activity of the noradrenergic and serotonergic systems of the brain. KM rats in the baseline (without the action of sound and the development of seizures) show a low content of norepinephrine in the hippocampus and hypothalamus, and during the development of AuK, noradrenaline deficiency is observed in the frontal cortex. After the formation of AuK, the serotonin metabolism, which is more intense than in the "0" rats, slows in the hippocampus, nucleus accumbens, and, especially, in the brainstem, and the serotonin deficiency in the striatum disappears. The features of noradrenaline metabolism in KM rats before and after AuK emphasize the important role of the cortex in the development of myoclonic seizures, as well as the possible involvement of the hippocampus and hypothalamus in tonic–clonic seizures. The high functional activity of the serotonergic system, which was revealed in KM rats in a number of brain structures, weakens in the baseline during the development of AuK. The results we obtained demonstrate and confirm the significant role of a brain monoamine imbalance in the genesis of epileptiform seizures in KM rats with genetically determined audiogenic epilepsy and in the development of AuK in them. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results