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282 results on '"Poletti, R."'

17. P444Effect of sex on reverse remodelling in chronic systolic heart failure

Author

Aimo, A., primary, Vergaro, G., additional, Castiglione, V., additional, Barison, A., additional, Pasanisi, E., additional, Petersen, C., additional, Chubuchny, V., additional, Giannoni, A., additional, Poletti, R., additional, Maffei, S., additional, Januzzi, J., additional, Passino, C., additional, and Emdin, M., additional

Published
2017
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18. Bioaccumulation of algal toxins and changes in physiological parameters in Mediterranean mussels from the North Adriatic Sea (Italy)

Author

BURATTI, SARA, FRANZELLITTI, SILVIA, FABBRI, ELENA, Poletti R., Ceredi A., Montanari G., Capuzzo A., Buratti S., Franzellitti S., Poletti R., Ceredi A., Montanari G., Capuzzo A., and Fabbri E.

Subjects
GENE EXPRESSION, animal structures, Hemocytes, Harmful Algal Bloom, Mollusk Venoms, Aquaculture, SIGNALING PATHWAYS, Mice, Algal toxin, Mediterranean Sea, ALGAL TOXINS, Animals, cyclic AMP, Chromatography, High Pressure Liquid, Glutathione Transferase, Mytilus, ANTIOXIDANT ENZYME ACTIVITY, Algal toxin, cyclic AMP, biomarkers, Mytilus galloprovincialis, MXR-rerlated gene expression, fungi, Oxocins, biomarkers, MUSSEL, Italy, Mytilus galloprovincialis, STRESS SYNDROME, Biological Assay, Marine Toxins, Seasons
Abstract

The Northwestern Adriatic Sea is a commercially important area in aquaculture, accounting for about 90% of the Italian mussel production, and it was subjected to recurring cases of mussel farm closures due to toxic algae poisoning. A spatial and temporal survey of four sites along the North Adriatic Sea coasts of Emilia Romagna (Italy) was undertaken to study the possible impairments of physiological parameters in Mytilus galloprovincialis naturally exposed to algal toxins. The sites were selected as part of the monitoring network for the assessment of algal toxins bioaccumulation by the competent Authority. Samples positive to paralytic shellfish toxins and to lipophilic toxins were detected through the mouse bioassay. Lipophilic toxins were assessed by HPLC. Decreasing yessotoxins (YTX) levels were observed in mussels from June to December, while homo-YTX contents increased concomitantly. Lysosome membrane stability (LMS), glutathione S-transferase and catalase activities, and multixenobiotic resistance (MXR)-related gene expressions were assessed as parameters related to the mussel health status and widely utilized in environmental biomonitoring. Levels of cAMP were also measured, as possibly involved in the algal toxin mechanisms of action. Low LMS values were observed in hemocytes from mussels positive to the mouse bioassay. MXR-related gene expressions were greatly inhibited in mussels positive to the mouse bioassay. Clear correlations were established between increasing homo-YTX contents (and decreasing YTX) and increasing cAMP levels in the tissues. Similarly, significant correlations were established between the increase of homo-YTX and cAMP levels, and the expressions of three MXR-related genes at submaximal toxin concentrations. In conclusion, YTXs may affect mussel physiological parameters, including hemocyte functionality, gene expression and cell signaling.

Published
2013

32. [Natriuretic peptides in heart failure]

Author

Emdin M, Poletti R, Alberto Giannoni, Mg, Mazzei, Mammini C, Gabutti A, Agazio A, Caprioli R, and Passino C

Subjects
Heart Failure, Humans, Natriuretic Peptides
Abstract

The recent discovery of cardiac endocrine function, together with the development of accurate and feasible assay methods for cardiac natriuretic hormone evaluation, i.e. for B-type natriuretic peptide (BNP) and inactive peptide NT-proBNP have confirmed their pathophysiological and clinical significance for cardiovascular disease assessment. Concerning heart failure, their value is for diagnostic screening in selected/unselected populations, for differential diagnosis of dyspnea and for prognostic stratification, and as a guide for follow-up and treatment of patients. Recent Italian recommendations pointed out that BNP/NT-proBNP has a role in ruling-out the diagnosis of heart failure in patients with dubious signs/symptoms: plasma BNP/NT-proBNP concentrations help in the clinical evaluation of chronic heart failure patients when risk stratification is needed, whereas the routine BNP/NT-proBNP assay is still not recommended to guide therapeutic decision-making.

Published
2006

33. Natruiretic peptides in heart failure

Author

Emdin, Michele, Poletti, R, Giannoni, A, Mazzei, Mg, Mammini, C, Gabutti, A, Agazio, A, Caprioli, R, and Passino, Claudio

Published
2006

42. A functional assay for yessotoxins

Author

Pierotti, S., Ferrari, S., Malaguti, C., Milandri, A., Poletti, R., and Rossini, Gian Paolo

Subjects
functional assays, cell-based assays, Shellfish poisoning, yessotoxin
Published
2003

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