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15 results on '"Pollard, Miriam"'

1. Parkinson’s families project: a UK-wide study of early onset and familial Parkinson’s disease

Author

Towns, Clodagh, Fang, Zih-Hua, Tan, Manuela M. X., Jasaityte, Simona, Schmaderer, Theresa M., Stafford, Eleanor J., Pollard, Miriam, Tilney, Russel, Hodgson, Megan, Wu, Lesley, Labrum, Robyn, Hehir, Jason, Polke, James, Lange, Lara M., Schapira, Anthony H. V., Bhatia, Kailash P., Singleton, Andrew B., Blauwendraat, Cornelis, Klein, Christine, Houlden, Henry, Wood, Nicholas W., Jarman, Paul R., Morris, Huw R., and Real, Raquel

Published
2024
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2. Genome-wide determinants of mortality and motor progression in Parkinson’s disease

Author

Tan, Manuela M. X., Lawton, Michael A., Pollard, Miriam I., Brown, Emmeline, Real, Raquel, Carrasco, Alejandro Martinez, Bekadar, Samir, Jabbari, Edwin, Reynolds, Regina H., Iwaki, Hirotaka, Blauwendraat, Cornelis, Kanavou, Sofia, Hubbard, Leon, Malek, Naveed, Grosset, Katherine A., Bajaj, Nin, Barker, Roger A., Burn, David J., Bresner, Catherine, Foltynie, Thomas, Wood, Nicholas W., Williams-Gray, Caroline H., Andreassen, Ole A., Toft, Mathias, Elbaz, Alexis, Artaud, Fanny, Brice, Alexis, Corvol, Jean-Christophe, Aasly, Jan, Farrer, Matthew J., Nalls, Michael A., Singleton, Andrew B., Williams, Nigel M., Ben-Shlomo, Yoav, Hardy, John, Hu, Michele T. M., Grosset, Donald G., Shoai, Maryam, Pihlstrøm, Lasse, and Morris, Huw R.

Published
2024
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3. Parkinson’s Families Project: a UK-wide study of early onset and familial Parkinson’s disease

Author

Schmaderer, Theresa M., primary, Towns, Clodagh, additional, Jasaityte, Simona, additional, Tan, Manuela M. X., additional, Pollard, Miriam, additional, Hodgson, Megan, additional, Wu, Lesley, additional, Tilney, Russel, additional, Labrum, Robyn, additional, Hehir, Jason, additional, Polke, James, additional, Bhatia, Kailash P., additional, Houlden, Henry, additional, Wood, Nicholas W., additional, Jarman, Paul R., additional, Morris, Huw R., additional, and Real, Raquel, additional

Published
2023
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4. Genome-wide determinants of mortality and motor progression in Parkinson’s disease

Author

Tan, Manuela MX, primary, Lawton, Michael A, additional, Pollard, Miriam I, additional, Brown, Emmeline, additional, Real, Raquel, additional, Martinez Carrasco, Alejandro, additional, Bekadar, Samir, additional, Jabbari, Edwin, additional, Reynolds, Regina H, additional, Iwaki, Hirotaka, additional, Blauwendraat, Cornelis, additional, Kanavou, Sofia, additional, Hubbard, Leon, additional, Malek, Naveed, additional, Grosset, Katherine A, additional, Bajaj, Nin, additional, Barker, Roger A, additional, Burn, David J, additional, Bresner, Catherine, additional, Foltynie, Thomas, additional, Wood, Nicholas W, additional, Williams-Gray, Caroline H, additional, Andreassen, Ole A, additional, Toft, Mathias, additional, Elbaz, Alexis, additional, Artaud, Fanny, additional, Brice, Alexis, additional, Corvol, Jean-Christophe, additional, Aasly, Jan, additional, Farrer, Matthew J, additional, Nalls, Michael A, additional, Singleton, Andrew B, additional, Williams, Nigel M, additional, Ben-Shlomo, Yoav, additional, Hardy, John, additional, Hu, Michele TM, additional, Grosset, Donald G, additional, Shoai, Maryam, additional, Pihlstrøm, Lasse, additional, and Morris, Huw R, additional

Published
2022
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5. Genome‐Wide Association Studies of Cognitive and Motor Progression in Parkinson's Disease

Author

Tan, Manuela M.X., primary, Lawton, Michael A., additional, Jabbari, Edwin, additional, Reynolds, Regina H., additional, Iwaki, Hirotaka, additional, Blauwendraat, Cornelis, additional, Kanavou, Sofia, additional, Pollard, Miriam I., additional, Hubbard, Leon, additional, Malek, Naveed, additional, Grosset, Katherine A., additional, Marrinan, Sarah L., additional, Bajaj, Nin, additional, Barker, Roger A., additional, Burn, David J., additional, Bresner, Catherine, additional, Foltynie, Thomas, additional, Wood, Nicholas W., additional, Williams‐Gray, Caroline H., additional, Hardy, John, additional, Nalls, Michael A., additional, Singleton, Andrew B., additional, Williams, Nigel M., additional, Ben‐Shlomo, Yoav, additional, Hu, Michele T.M., additional, Grosset, Donald G., additional, Shoai, Maryam, additional, and Morris, Huw R., additional

Published
2020
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7. Genome-wide association studies of cognitive and motor progression in Parkinson's disease

Author

Tan, Manuela MX, primary, Lawton, Michael A, additional, Jabbari, Edwin, additional, Reynolds, Regina H, additional, Iwaki, Hirotaka, additional, Blauwendraat, Cornelis, additional, Kanavou, Sofia, additional, Pollard, Miriam I, additional, Hubbard, Leon, additional, Malek, Naveed, additional, Grosset, Katherine A, additional, Marrinan, Sarah L, additional, Bajaj, Nin, additional, Barker, Roger A, additional, Burn, David J, additional, Bresner, Catherine, additional, Foltynie, Thomas, additional, Wood, Nicholas W, additional, Williams-Gray, Caroline H, additional, Hardy, John, additional, Nalls, Michael A, additional, Singleton, Andrew B, additional, Williams, Nigel M, additional, Ben-Shlomo, Yoav, additional, Hu, Michele TM, additional, Grosset, Donald G, additional, Shoai, Maryam, additional, and Morris, Huw R, additional

Published
2020
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8. Supplementary_Table_1 - Out with the old and in with the new: The role of intolerance of uncertainty in reversal of threat and safety

Author

Morriss, Jayne, Saldarini, Francesco, Chapman, Catherine, Pollard, Miriam, and Reekum, Carien M. Van

Subjects
FOS: Psychology, FOS: Clinical medicine, 170199 Psychology not elsewhere classified, 110319 Psychiatry (incl. Psychotherapy)
Abstract

Supplementary_Table_1 for Out with the old and in with the new: The role of intolerance of uncertainty in reversal of threat and safety by Jayne Morriss, Francesco Saldarini, Catherine Chapman, Miriam Pollard, and Carien M. van Reekum in Journal of Experimental Psychopathology

Published
2019
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10. Genome‐Wide Association Studies of Cognitive and Motor Progression in Parkinson's Disease.

Author

Tan, Manuela M.X., Lawton, Michael A., Jabbari, Edwin, Reynolds, Regina H., Iwaki, Hirotaka, Blauwendraat, Cornelis, Kanavou, Sofia, Pollard, Miriam I., Hubbard, Leon, Malek, Naveed, Grosset, Katherine A., Marrinan, Sarah L., Bajaj, Nin, Barker, Roger A., Burn, David J., Bresner, Catherine, Foltynie, Thomas, Wood, Nicholas W., Williams‐Gray, Caroline H., and Hardy, John

Abstract

Background: There are currently no treatments that stop or slow the progression of Parkinson's disease (PD). Case–control genome‐wide association studies have identified variants associated with disease risk, but not progression. The objective of the current study was to identify genetic variants associated with PD progression. Methods: We analyzed 3 large longitudinal cohorts: Tracking Parkinson's, Oxford Discovery, and the Parkinson's Progression Markers Initiative. We included clinical data for 3364 patients with 12,144 observations (mean follow‐up 4.2 years). We used a new method in PD, following a similar approach in Huntington's disease, in which we combined multiple assessments using a principal components analysis to derive scores for composite, motor, and cognitive progression. These scores were analyzed in linear regression in genome‐wide association studies. We also performed a targeted analysis of the 90 PD risk loci from the latest case–control meta‐analysis. Results: There was no overlap between variants associated with PD risk, from case–control studies, and PD age at onset versus PD progression. The APOE ε4 tagging variant, rs429358, was significantly associated with composite and cognitive progression in PD. Conditional analysis revealed several independent signals in the APOE locus for cognitive progression. No single variants were associated with motor progression. However, in gene‐based analysis, ATP8B2, a phospholipid transporter related to vesicle formation, was nominally associated with motor progression (P = 5.3 × 10−6). Conclusions: We provide early evidence that this new method in PD improves measurement of symptom progression. We show that the APOE ε4 allele drives progressive cognitive impairment in PD. Replication of this method and results in independent cohorts are needed. © 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society [ABSTRACT FROM AUTHOR]

Published
2021
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12. Nicodemus

Author

Pollard, Miriam

Subjects
Philosophy and religion
Published
2003

13. Monastic Solitude According to Our Cistercian Tradition, Taking into Account Contemporary Thought and Using Present-Day Language.

Author

Pollard, Miriam and Davis, Thomas X.

Subjects
*MONASTICISM & religious orders, *LONELINESS, *SOLITUDE, *CISTERCIAN monasteries, *LIFE, *PRIVACY
Abstract

The article focuses on monastic solitude according to Cistercian tradition taking into account contemporary thought and using present-day language. Solitude is defined as a situation in which a person is alone, or the condition of a person being alone. This article is an effort to stimulate thought and exchange. It can only indicate areas of approach, since solitude, as a foundational aspect of the monastic journey, carries too many implications to be treated in a brief exposition. In addition, an entire document could be developed in which the principles of the study undertaken would be applied to the life situation of associates and others who live the Cistercian charism in a lay calling.

Published
2005

14. Genome-Wide Association Studies of Cognitive and Motor Progression in Parkinson's Disease

Author

Tan, Manuela MX, Lawton, Michael A, Jabbari, Edwin, Reynolds, Regina H, Iwaki, Hirotaka, Blauwendraat, Cornelis, Kanavou, Sofia, Pollard, Miriam I, Hubbard, Leon, Malek, Naveed, Grosset, Katherine A, Marrinan, Sarah L, Bajaj, Nin, Barker, Roger A, Burn, David J, Bresner, Catherine, Foltynie, Thomas, Wood, Nicholas W, Williams-Gray, Caroline H, Hardy, John, Nalls, Michael A, Singleton, Andrew B, Williams, Nigel M, Ben-Shlomo, Yoav, Hu, Michele TM, Grosset, Donald G, Shoai, Maryam, and Morris, Huw R

Subjects
genome-wide association study, Cognition, Parkinson's disease, Disease Progression, Humans, genetics, Parkinson Disease, progression, Biomarkers, 3. Good health
Abstract

BACKGROUND: There are currently no treatments that stop or slow the progression of Parkinson's disease (PD). Case-control genome-wide association studies have identified variants associated with disease risk, but not progression. The objective of the current study was to identify genetic variants associated with PD progression. METHODS: We analyzed 3 large longitudinal cohorts: Tracking Parkinson's, Oxford Discovery, and the Parkinson's Progression Markers Initiative. We included clinical data for 3364 patients with 12,144 observations (mean follow-up 4.2 years). We used a new method in PD, following a similar approach in Huntington's disease, in which we combined multiple assessments using a principal components analysis to derive scores for composite, motor, and cognitive progression. These scores were analyzed in linear regression in genome-wide association studies. We also performed a targeted analysis of the 90 PD risk loci from the latest case-control meta-analysis. RESULTS: There was no overlap between variants associated with PD risk, from case-control studies, and PD age at onset versus PD progression. The APOE ε4 tagging variant, rs429358, was significantly associated with composite and cognitive progression in PD. Conditional analysis revealed several independent signals in the APOE locus for cognitive progression. No single variants were associated with motor progression. However, in gene-based analysis, ATP8B2, a phospholipid transporter related to vesicle formation, was nominally associated with motor progression (P = 5.3 × 10-6 ). CONCLUSIONS: We provide early evidence that this new method in PD improves measurement of symptom progression. We show that the APOE ε4 allele drives progressive cognitive impairment in PD. Replication of this method and results in independent cohorts are needed. © 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

15. Blessed are those who have not seen.

Author

Pollard, Miriam

Abstract

The author reflects on the meaning of the Biblical verse John 20:29. She states that the verse may mean that it is better to receive the presence of Jesus Christ through the proclamation of the church than through one's sensual perception. She claims that John is saying that the word of God is not a secondhand proclamation. She describes the testimony as an immediate presence of Jesus Christ and a touch to the spiritual senses.

Published
2008

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