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1. Nucleosome fibre topology guides transcription factor binding to enhancers

Author

O’Dwyer, Michael R., Azagury, Meir, Furlong, Katharine, Alsheikh, Amani, Hall-Ponsele, Elisa, Pinto, Hugo, Fyodorov, Dmitry V., Jaber, Mohammad, Papachristoforou, Eleni, Benchetrit, Hana, Ashmore, James, Makedonski, Kirill, Rahamim, Moran, Hanzevacki, Marta, Yassen, Hazar, Skoda, Samuel, Levy, Adi, Pollard, Steven M., Skoultchi, Arthur I., Buganim, Yosef, and Soufi, Abdenour

Published
2024
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8. Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis

Author

Huang, Miller, Tailor, Jignesh, Zhen, Qiqi, Gillmor, Aaron H, Miller, Matthew L, Weishaupt, Holger, Chen, Justin, Zheng, Tina, Nash, Emily K, McHenry, Lauren K, An, Zhenyi, Ye, Fubaiyang, Takashima, Yasuhiro, Clarke, James, Ayetey, Harold, Cavalli, Florence MG, Luu, Betty, Moriarity, Branden S, Ilkhanizadeh, Shirin, Chavez, Lukas, Yu, Chunying, Kurian, Kathreena M, Magnaldo, Thierry, Sevenet, Nicolas, Koch, Philipp, Pollard, Steven M, Dirks, Peter, Snyder, Michael P, Largaespada, David A, Cho, Yoon Jae, Phillips, Joanna J, Swartling, Fredrik J, Morrissy, A Sorana, Kool, Marcel, Pfister, Stefan M, Taylor, Michael D, Smith, Austin, and Weiss, William A

Subjects
Medical Biotechnology, Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Pediatric Cancer, Genetics, Transplantation, Brain Disorders, Pediatric, Regenerative Medicine, Brain Cancer, Stem Cell Research - Nonembryonic - Human, Cancer, Neurosciences, Human Genome, Stem Cell Research, Stem Cell Research - Nonembryonic - Non-Human, Rare Diseases, Biotechnology, 2.1 Biological and endogenous factors, Animals, Basal Cell Nevus Syndrome, Brain Neoplasms, Carcinogenesis, DEAD-box RNA Helicases, Disease Models, Animal, Genetic Engineering, Genetic Predisposition to Disease, Humans, Medulloblastoma, Mice, Mice, SCID, N-Myc Proto-Oncogene Protein, Neoplasm Proteins, Neural Stem Cells, Neuroepithelial Cells, Patched-1 Receptor, Pluripotent Stem Cells, Stem Cell Transplantation, Transplantation, Heterologous, SHH, human pluripotent stem cells, medulloblastoma, neuroepithelial stem cells, Biological Sciences, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences
Abstract

Human neural stem cell cultures provide progenitor cells that are potential cells of origin for brain cancers. However, the extent to which genetic predisposition to tumor formation can be faithfully captured in stem cell lines is uncertain. Here, we evaluated neuroepithelial stem (NES) cells, representative of cerebellar progenitors. We transduced NES cells with MYCN, observing medulloblastoma upon orthotopic implantation in mice. Significantly, transcriptomes and patterns of DNA methylation from xenograft tumors were globally more representative of human medulloblastoma compared to a MYCN-driven genetically engineered mouse model. Orthotopic transplantation of NES cells generated from Gorlin syndrome patients, who are predisposed to medulloblastoma due to germline-mutated PTCH1, also generated medulloblastoma. We engineered candidate cooperating mutations in Gorlin NES cells, with mutation of DDX3X or loss of GSE1 both accelerating tumorigenesis. These findings demonstrate that human NES cells provide a potent experimental resource for dissecting genetic causation in medulloblastoma.

Published
2019

9. Myeloid cell interferon secretion restricts Zika flavivirus infection of developing and malignant human neural progenitor cells

Author

Bulstrode, Harry, Girdler, Gemma C., Gracia, Tannia, Aivazidis, Alexander, Moutsopoulos, Ilias, Young, Adam M.H., Hancock, John, He, Xiaoling, Ridley, Katherine, Xu, Zhaoyang, Stockley, John H., Finlay, John, Hallou, Clement, Fajardo, Teodoro, Fountain, Daniel M., van Dongen, Stijn, Joannides, Alexis, Morris, Robert, Mair, Richard, Watts, Colin, Santarius, Thomas, Price, Stephen J., Hutchinson, Peter J.A., Hodson, Emma J., Pollard, Steven M., Mohorianu, Irina, Barker, Roger A., Sweeney, Trevor R., Bayraktar, Omer, Gergely, Fanni, and Rowitch, David H.

Published
2022
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14. Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion

Author

Gangoso, Ester, Southgate, Benjamin, Bradley, Leanne, Rus, Stefanie, Galvez-Cancino, Felipe, McGivern, Niamh, Güç, Esra, Kapourani, Chantriolnt-Andreas, Byron, Adam, Ferguson, Kirsty M., Alfazema, Neza, Morrison, Gillian, Grant, Vivien, Blin, Carla, Sou, IengFong, Marques-Torrejon, Maria Angeles, Conde, Lucia, Parrinello, Simona, Herrero, Javier, Beck, Stephan, Brandner, Sebastian, Brennan, Paul M., Bertone, Paul, Pollard, Jeffrey W., Quezada, Sergio A., Sproul, Duncan, Frame, Margaret C., Serrels, Alan, and Pollard, Steven M.

Published
2021
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16. The white matter is a pro-differentiative niche for glioblastoma

Author

Brooks, Lucy J., Clements, Melanie P., Burden, Jemima J., Kocher, Daniela, Richards, Luca, Devesa, Sara Castro, Zakka, Leila, Woodberry, Megan, Ellis, Michael, Jaunmuktane, Zane, Brandner, Sebastian, Morrison, Gillian, Pollard, Steven M., Dirks, Peter B., Marguerat, Samuel, and Parrinello, Simona

Published
2021
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21. Author Reply to Peer Reviews of CDK12/CDK13 inhibition disrupts a transcriptional program critical for glioblastoma survival

Author

Lier, Silje, primary, Kocijancic, Anja, additional, Narum, Martine, additional, Lund, Solveig Osnes, additional, Lipsa, Anuja, additional, Frauenknecht, Katrin B.M., additional, Rein, Idun Dale, additional, Jain, Preeti, additional, Lång, Anna, additional, Lång, Emma, additional, Meyer, Niklas, additional, Datta, Aparajita, additional, Anand, Santosh, additional, Nesse, Gaute, additional, Forstrøm, Rune Johansen, additional, Klungland, Arne, additional, Rinholm, Johanne Egge, additional, Bøe, Stig Ove, additional, Anand, Ashish, additional, Pollard, Steven M., additional, Golebiewska, Anna, additional, Niclou, Simone P., additional, Somyajit, Kumar, additional, Lerdrup, Mads, additional, and Pandey, Deo Prakash, additional

Published
2023
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24. Challenges to curing primary brain tumours

Author

Aldape, Kenneth, Brindle, Kevin M., Chesler, Louis, Chopra, Rajesh, Gajjar, Amar, Gilbert, Mark R., Gottardo, Nicholas, Gutmann, David H., Hargrave, Darren, Holland, Eric C., Jones, David T. W., Joyce, Johanna A., Kearns, Pamela, Kieran, Mark W., Mellinghoff, Ingo K., Merchant, Melinda, Pfister, Stefan M., Pollard, Steven M., Ramaswamy, Vijay, Rich, Jeremy N., Robinson, Giles W., Rowitch, David H., Sampson, John H., Taylor, Michael D., Workman, Paul, and Gilbertson, Richard J.

Published
2019
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27. Contributors

Author

Aranda, Sergi, primary, Arcidiacono, Orazio Angelo, additional, Artus, Jerome, additional, Bártová, Eva, additional, Battle, Stephanie L., additional, Bavli, Danny, additional, Biran, Alva, additional, Branco, Miguel R., additional, Bressan, Raul Bardini, additional, Caporale, Nicolò, additional, Di Croce, Luciano, additional, Dion, Camille, additional, Gonzalez, Inma, additional, Hawkins, R. David, additional, Kozulin, Chen, additional, Krejčí, Jana, additional, Legartová, Soňa, additional, Leitch, Harry G., additional, Lopez-Tobon, Alejandro, additional, Mermoud, Jacqueline E., additional, Meshorer, Eran, additional, Navarro, Pablo, additional, Owens, Nick D.L., additional, Platania, Angeliki, additional, Pollard, Steven M., additional, Poot, Raymond A., additional, Ram, Oren, additional, Schlesinger, Sharon, additional, Sexton, Tom, additional, Stixova, Lenka, additional, Testa, Giuseppe, additional, and Trattaro, Sebastiano, additional

Published
2020
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29. Specific roles of laminins during vertebrate embryogenesis

Author

Pollard, Steven Michael

Subjects
590, Zoology
Abstract

The notochord is critical for the normal development of vertebrate embryos. Zebrafish mutants, bashful (bal), grumpy (gup) and sleepy (sly) were identified in mutagenesis screens and have defects in notochord differentiation. By positional cloning I identified lama1, encoding Laminin α1, as a candidate for the bal gene. Analysis of mRNA expression, antisense knockdown and sequencing of the mutant lama1, confirmed that mutations in this gene are responsible for the bal phenotype. A similar approach was taken to identify the gup gene. Meiotic mapping identified a region containing lamb1, encoding Laminin β1. Cloning and sequencing of lamb1 from mutants revealed a non-sense mutation. These results identify a role for Laminin αl and Laminin β1 in notochord differentiation. Concurrent work in our laboratory revealed that the third mutant, sly, encodes the Laminin γl chain (Parsons et al., 2002). Thus, the laminin 1 isoform, a heterotrimer comprising the α1β1γ1 chains, is necessary for notochord differentiation. bal mutants differ from gup and sly, as failure of notochord differentiation is not as extensive, occurring only in anterior regions. We hypothesised this was due to a redundant role of another a chain. Characterisation of lama4 and lama5, encoding Laminin α4 and α5 chains, respectively, showed that both control aspects of notochord differentiation. Furthermore, lama5 has a functionally redundant role with lama1 during CNS development. Characterisation of lama2 identifies a role for Laminin α2 chain in muscle function, consistent with loss-of-function phenotypes in human and mouse. Hence, I demonstrate different roles for specific laminin chains during zebrafish development, confirming and extending results from studies in other vertebrate systems. Finally, I studied integrin α6, integrin β4, and integrin-linked kinase (ILK), to determine their role during development. The results suggest these genes control cell movements during gastrulation, rather than notochord differentiation.

Published
2002

30. A novel ILK/STAT3 pathway controls plasticity in a neural stem cell model of glioblastoma.

Author

Loftus, Alexander E.P., primary, Romano, Marianna S., additional, Nguyen Phuong, Anh, additional, Muir, Morwenna T., additional, Dawson, John C., additional, Avalle, Lidia, additional, Douglas, Adam T., additional, Mort, Richard L., additional, Byron, Adam, additional, Carragher, Neil O., additional, Pollard, Steven M., additional, Brunton, Valerie G., additional, and Frame, Margaret C., additional

Published
2023
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33. A novel ILK/STAT3 pathway controls plasticity in a neural stem cell model of glioblastoma

Author

Loftus, Alexander E. P., Romano, Marianna S., Phuong, Anh Nguyen, Muir, Morwenna T., Dawson, John C., Avalle, Lidia, Douglas, Adam T., Mort, Richard L., Byron, Adam, Carragher, Neil O., Pollard, Steven M., Brunton, Valerie G., Frame, Margaret C., Loftus, Alexander E. P., Romano, Marianna S., Phuong, Anh Nguyen, Muir, Morwenna T., Dawson, John C., Avalle, Lidia, Douglas, Adam T., Mort, Richard L., Byron, Adam, Carragher, Neil O., Pollard, Steven M., Brunton, Valerie G., and Frame, Margaret C.

Published
2023

34. Supplementary Figure 5 from Cancer-Specific Requirement for BUB1B/BUBR1 in Human Brain Tumor Isolates and Genetically Transformed Cells

Author

Ding, Yu, primary, Hubert, Christopher G., primary, Herman, Jacob, primary, Corrin, Philip, primary, Toledo, Chad M., primary, Skutt-Kakaria, Kyobi, primary, Vazquez, Julio, primary, Basom, Ryan, primary, Zhang, Bin, primary, Risler, Jennifer K., primary, Pollard, Steven M., primary, Nam, Do-Hyun, primary, Delrow, Jeffery J., primary, Zhu, Jun, primary, Lee, Jeongwu, primary, DeLuca, Jennifer, primary, Olson, James M., primary, and Paddison, Patrick J., primary

Published
2023
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35. Supplementary Figure 4 from Cancer-Specific Requirement for BUB1B/BUBR1 in Human Brain Tumor Isolates and Genetically Transformed Cells

Author

Ding, Yu, primary, Hubert, Christopher G., primary, Herman, Jacob, primary, Corrin, Philip, primary, Toledo, Chad M., primary, Skutt-Kakaria, Kyobi, primary, Vazquez, Julio, primary, Basom, Ryan, primary, Zhang, Bin, primary, Risler, Jennifer K., primary, Pollard, Steven M., primary, Nam, Do-Hyun, primary, Delrow, Jeffery J., primary, Zhu, Jun, primary, Lee, Jeongwu, primary, DeLuca, Jennifer, primary, Olson, James M., primary, and Paddison, Patrick J., primary

Published
2023
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36. Supplementary Figure 1 from Cancer-Specific Requirement for BUB1B/BUBR1 in Human Brain Tumor Isolates and Genetically Transformed Cells

Author

Ding, Yu, primary, Hubert, Christopher G., primary, Herman, Jacob, primary, Corrin, Philip, primary, Toledo, Chad M., primary, Skutt-Kakaria, Kyobi, primary, Vazquez, Julio, primary, Basom, Ryan, primary, Zhang, Bin, primary, Risler, Jennifer K., primary, Pollard, Steven M., primary, Nam, Do-Hyun, primary, Delrow, Jeffery J., primary, Zhu, Jun, primary, Lee, Jeongwu, primary, DeLuca, Jennifer, primary, Olson, James M., primary, and Paddison, Patrick J., primary

Published
2023
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37. Data from Cancer-Specific Requirement for BUB1B/BUBR1 in Human Brain Tumor Isolates and Genetically Transformed Cells

Author

Ding, Yu, primary, Hubert, Christopher G., primary, Herman, Jacob, primary, Corrin, Philip, primary, Toledo, Chad M., primary, Skutt-Kakaria, Kyobi, primary, Vazquez, Julio, primary, Basom, Ryan, primary, Zhang, Bin, primary, Risler, Jennifer K., primary, Pollard, Steven M., primary, Nam, Do-Hyun, primary, Delrow, Jeffery J., primary, Zhu, Jun, primary, Lee, Jeongwu, primary, DeLuca, Jennifer, primary, Olson, James M., primary, and Paddison, Patrick J., primary

Published
2023
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38. Supplementary Figure 7 from Cancer-Specific Requirement for BUB1B/BUBR1 in Human Brain Tumor Isolates and Genetically Transformed Cells

Author

Ding, Yu, primary, Hubert, Christopher G., primary, Herman, Jacob, primary, Corrin, Philip, primary, Toledo, Chad M., primary, Skutt-Kakaria, Kyobi, primary, Vazquez, Julio, primary, Basom, Ryan, primary, Zhang, Bin, primary, Risler, Jennifer K., primary, Pollard, Steven M., primary, Nam, Do-Hyun, primary, Delrow, Jeffery J., primary, Zhu, Jun, primary, Lee, Jeongwu, primary, DeLuca, Jennifer, primary, Olson, James M., primary, and Paddison, Patrick J., primary

Published
2023
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39. Supplementary Table 1 from Cancer-Specific Requirement for BUB1B/BUBR1 in Human Brain Tumor Isolates and Genetically Transformed Cells

Author

Ding, Yu, primary, Hubert, Christopher G., primary, Herman, Jacob, primary, Corrin, Philip, primary, Toledo, Chad M., primary, Skutt-Kakaria, Kyobi, primary, Vazquez, Julio, primary, Basom, Ryan, primary, Zhang, Bin, primary, Risler, Jennifer K., primary, Pollard, Steven M., primary, Nam, Do-Hyun, primary, Delrow, Jeffery J., primary, Zhu, Jun, primary, Lee, Jeongwu, primary, DeLuca, Jennifer, primary, Olson, James M., primary, and Paddison, Patrick J., primary

Published
2023
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40. Supplementary Figure 8 from Cancer-Specific Requirement for BUB1B/BUBR1 in Human Brain Tumor Isolates and Genetically Transformed Cells

Author

Ding, Yu, primary, Hubert, Christopher G., primary, Herman, Jacob, primary, Corrin, Philip, primary, Toledo, Chad M., primary, Skutt-Kakaria, Kyobi, primary, Vazquez, Julio, primary, Basom, Ryan, primary, Zhang, Bin, primary, Risler, Jennifer K., primary, Pollard, Steven M., primary, Nam, Do-Hyun, primary, Delrow, Jeffery J., primary, Zhu, Jun, primary, Lee, Jeongwu, primary, DeLuca, Jennifer, primary, Olson, James M., primary, and Paddison, Patrick J., primary

Published
2023
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41. Supplementary Figure 2 from Cancer-Specific Requirement for BUB1B/BUBR1 in Human Brain Tumor Isolates and Genetically Transformed Cells

Author

Ding, Yu, primary, Hubert, Christopher G., primary, Herman, Jacob, primary, Corrin, Philip, primary, Toledo, Chad M., primary, Skutt-Kakaria, Kyobi, primary, Vazquez, Julio, primary, Basom, Ryan, primary, Zhang, Bin, primary, Risler, Jennifer K., primary, Pollard, Steven M., primary, Nam, Do-Hyun, primary, Delrow, Jeffery J., primary, Zhu, Jun, primary, Lee, Jeongwu, primary, DeLuca, Jennifer, primary, Olson, James M., primary, and Paddison, Patrick J., primary

Published
2023
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42. Supplementary Figure 6 from Cancer-Specific Requirement for BUB1B/BUBR1 in Human Brain Tumor Isolates and Genetically Transformed Cells

Author

Ding, Yu, primary, Hubert, Christopher G., primary, Herman, Jacob, primary, Corrin, Philip, primary, Toledo, Chad M., primary, Skutt-Kakaria, Kyobi, primary, Vazquez, Julio, primary, Basom, Ryan, primary, Zhang, Bin, primary, Risler, Jennifer K., primary, Pollard, Steven M., primary, Nam, Do-Hyun, primary, Delrow, Jeffery J., primary, Zhu, Jun, primary, Lee, Jeongwu, primary, DeLuca, Jennifer, primary, Olson, James M., primary, and Paddison, Patrick J., primary

Published
2023
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43. Supplementary Figure 9 from Cancer-Specific Requirement for BUB1B/BUBR1 in Human Brain Tumor Isolates and Genetically Transformed Cells

Author

Ding, Yu, primary, Hubert, Christopher G., primary, Herman, Jacob, primary, Corrin, Philip, primary, Toledo, Chad M., primary, Skutt-Kakaria, Kyobi, primary, Vazquez, Julio, primary, Basom, Ryan, primary, Zhang, Bin, primary, Risler, Jennifer K., primary, Pollard, Steven M., primary, Nam, Do-Hyun, primary, Delrow, Jeffery J., primary, Zhu, Jun, primary, Lee, Jeongwu, primary, DeLuca, Jennifer, primary, Olson, James M., primary, and Paddison, Patrick J., primary

Published
2023
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44. Supplementary Figure 3 from Cancer-Specific Requirement for BUB1B/BUBR1 in Human Brain Tumor Isolates and Genetically Transformed Cells

Author

Ding, Yu, primary, Hubert, Christopher G., primary, Herman, Jacob, primary, Corrin, Philip, primary, Toledo, Chad M., primary, Skutt-Kakaria, Kyobi, primary, Vazquez, Julio, primary, Basom, Ryan, primary, Zhang, Bin, primary, Risler, Jennifer K., primary, Pollard, Steven M., primary, Nam, Do-Hyun, primary, Delrow, Jeffery J., primary, Zhu, Jun, primary, Lee, Jeongwu, primary, DeLuca, Jennifer, primary, Olson, James M., primary, and Paddison, Patrick J., primary

Published
2023
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45. Supplementary Methods from Cancer-Specific Requirement for BUB1B/BUBR1 in Human Brain Tumor Isolates and Genetically Transformed Cells

Author

Ding, Yu, primary, Hubert, Christopher G., primary, Herman, Jacob, primary, Corrin, Philip, primary, Toledo, Chad M., primary, Skutt-Kakaria, Kyobi, primary, Vazquez, Julio, primary, Basom, Ryan, primary, Zhang, Bin, primary, Risler, Jennifer K., primary, Pollard, Steven M., primary, Nam, Do-Hyun, primary, Delrow, Jeffery J., primary, Zhu, Jun, primary, Lee, Jeongwu, primary, DeLuca, Jennifer, primary, Olson, James M., primary, and Paddison, Patrick J., primary

Published
2023
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