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1. Dark Matter Line Searches with the Cherenkov Telescope Array

Author

Abe, S., Abhir, J., Abhishek, A., Acero, F., Acharyya, A., Adam, R., Aguasca-Cabot, A., Agudo, I., Aguirre-Santaella, A., Alfaro, J., Alfaro, R., Alvarez-Crespo, N., Batista, R. Alves, Amans, J. -P., Amato, E., Ambrosi, G., Angel, L., Aramo, C., Arcaro, C., Arnesen, T. T. H., Arrabito, L., Asano, K., Ascasibar, Y., Aschersleben, J., Ashkar, H., Backes, M., Baktash, A., Balazs, C., Balbo, M., Larriva, A. Baquero, Martins, V. Barbosa, de Almeida, U. Barres, Barrio, J. A., Batković, I., Batzofin, R., Baxter, J., González, J. Becerra, Beck, G., Benbow, W., Berge, D., Bernardini, E., Bernete, J., Bernlöhr, K., Berti, A., Bertucci, B., Bhattacharjee, P., Bhattacharyya, S., Bigongiari, C., Biland, A., Bissaldi, E., Biteau, J., Blanch, O., Blazek, J., Bocchino, F., Boisson, C., Bolmont, J., Bonnoli, G., Bonollo, A., Bordas, P., Bosnjak, Z., Bottacini, E., Böttcher, M., Bringmann, T., Bronzini, E., Brose, R., Brown, A. M., Brunelli, G., Bulgarelli, A., Bulik, T., Burelli, I., Burmistrov, L., Burton, M., Buscemi, M., Bylund, T., Cailleux, J., Campoy-Ordaz, A., Cantlay, B. K., Capasso, G., Caproni, A., Capuzzo-Dolcetta, R., Caraveo, P., Caroff, S., Carosi, A., Carosi, R., Carquin, E., Carrasco, M. -S., Cassol, F., Castaldini, L., Castrejon, N., Castro-Tirado, A. J., Cerasole, D., Cerruti, M., Chadwick, P. M., Chaty, S., Chen, A. W., Chernyakova, M., Chiavassa, A., Chudoba, J., Chytka, L., Cicciari, G. M., Cifuentes, A., Araujo, C. H. Coimbra, Colapietro, M., Conforti, V., Conte, F., Contreras, J. L., Costa, A., Costantini, H., Cotter, G., Cristofari, P., Cuevas, O., Curtis-Ginsberg, Z., D'Amico, G., D'Ammando, F., Dai, S., Dalchenko, M., Dazzi, F., De Angelis, A., de Lavergne, M. de Bony, De Caprio, V., Pino, E. M. de Gouveia Dal, De Lotto, B., De Lucia, M., de Menezes, R., de Naurois, M., de Souza, V., del Peral, L., del Valle, M. V., Giler, A. G. Delgado, Mengual, J. Delgado, Delgado, C., Dell'aiera, M., della Volpe, D., Depaoli, D., Di Girolamo, T., Di Piano, A., Di Pierro, F., Di Tria, R., Di Venere, L., Díaz, C., Diebold, S., Dinesh, A., Djuvsland, J., Dominik, R. M., Prester, D. Dominis, Donini, A., Dorner, D., Dörner, J., Doro, M., Dournaux, J. -L., Duangchan, C., Dubos, C., Ducci, L., Dwarkadas, V. V., Ebr, J., Eckner, C., Egberts, K., Einecke, S., Elsässer, D., Emery, G., Errando, M., Escanuela, C., Escarate, P., Godoy, M. Escobar, Escudero, J., Esposito, P., Ettori, S., Falceta-Goncalves, D., Fedorova, E., Fegan, S., Feng, Q., Ferrand, G., Ferrarotto, F., Fiandrini, E., Fiasson, A., Filipovic, M., Fioretti, V., Fiori, M., Foffano, L., Guiteras, L. Font, Fontaine, G., Fröse, S., Fukazawa, Y., Fukui, Y., Furniss, A., Galanti, G., Galaz, G., Galelli, C., Gallozzi, S., Gammaldi, V., Garczarczyk, M., Gasbarra, C., Gasparrini, D., Ghalumyan, A., Gianotti, F., Giarrusso, M., Paiva, J. G. Giesbrecht Formiga, Giglietto, N., Giordano, F., Giuffrida, R., Glicenstein, J. -F., Glombitza, J., Goldoni, P., González, J. M., González, M. M., Coelho, J. Goulart, Gradetzke, T., Granot, J., Grasso, D., Grau, R., Gréaux, L., Green, D., Green, J. G., Grolleron, G., Guedes, L. M. V., Gueta, O., Hackfeld, J., Hadasch, D., Hamal, P., Hanlon, W., Hara, S., Harvey, V. M., Hassan, T., Hayashi, K., Heß, B., Heckmann, L., Heller, M., Cadena, S. Hernández, Hervet, O., Hinton, J., Hiroshima, N., Hnatyk, B., Hnatyk, R., Hofmann, W., Holder, J., Horan, D., Horvath, P., Hovatta, T., Hrabovsky, M., Hrupec, D., Iarlori, M., Inada, T., Incardona, F., Inoue, S., Inoue, Y., Iocco, F., Iori, M., Ishio, K., Jamrozy, M., Janecek, P., Jankowsky, F., Jean, P., Quiles, J. Jimenez, Jin, W., Juramy-Gilles, C., Jurysek, J., Kagaya, M., Kalekin, O., Karas, V., Katagiri, H., Kataoka, J., Kaufmann, S., Kazanas, D., Kerszberg, D., Kieda, D. B., Kleiner, T., Kluge, G., Kobayashi, Y., Kohri, K., Komin, N., Kornecki, P., Kosack, K., Kowal, G., Kubo, H., Kushida, J., La Barbera, A., La Palombara, N., Láinez, M., Lamastra, A., Lapington, J., Laporte, P., Lazarević, S., Lazendic-Galloway, J., Lemoine-Goumard, M., Lenain, J. -P., Leone, F., Leonora, E., Leto, G., Lindfors, E., Linhoff, M., Liodakis, I., Lipniacka, A., Lombardi, S., Longo, F., López-Coto, R., López-Moya, M., López-Oramas, A., Loporchio, S., Bahilo, J. Lozano, Luque-Escamilla, P. L., Macias, O., Majumdar, P., Mallamaci, M., Malyshev, D., Mandat, D., Manicò, G., Mariotti, M., Márquez, I., Marquez, P., Marsella, G., Martí, J., Martínez, G. A., Martínez, M., Martinez, O., Marty, C., Mas-Aguilar, A., Mastropietro, M., Mazin, D., Menchiari, S., Mestre, E., Meunier, J. -L., Meyer, D. M. -A., Meyer, M., Miceli, D., Miceli, M., Michailidis, M., Michałowski, J., Miener, T., Miranda, J. M., Mitchell, A., Mizote, M., Mizuno, T., Moderski, R., Molero, M., Molfese, C., Molina, E., Montaruli, T., Moralejo, A., Morcuende, D., Morselli, A., Moulin, E., Zamanillo, V. Moya, Munari, K., Murach, T., Muraczewski, A., Muraishi, H., Nakamori, T., Nayak, A., Nemmen, R., Neto, J. P., Nickel, L., Niemiec, J., Nieto, D., Rosillo, M. Nievas, Nikołajuk, M., Nikolić, L., Nishijima, K., Noda, K., Nosek, D., Novotny, V., Nozaki, S., Ohishi, M., Ohtani, Y., Okumura, A., Olive, J. -F., Ong, R. A., Orienti, M., Orito, R., Orlandini, M., Orlando, E., Orlando, S., Ostrowski, M., Otero-Santos, J., Oya, I., Pagano, I., Pagliaro, A., Palatiello, M., Panebianco, G., Paneque, D., Pantaleo, F. R., Paredes, J. M., Parmiggiani, N., Patricelli, B., Pe'er, A., Pech, M., Pecimotika, M., Pensec, U., Peresano, M., Pérez-Romero, J., Persic, M., Peters, K. P., Petruk, O., Piano, G., Pierre, E., Pietropaolo, E., Pihet, M., Pinchbeck, L., Pirola, G., Pittori, C., Plard, C., Podobnik, F., Pohl, M., Pollet, V., Ponti, G., Prandini, E., Principe, G., Priyadarshi, C., Produit, N., Prouza, M., Pueschel, E., Pühlhofer, G., Pumo, M. L., Queiroz, F., Quirrenbach, A., Rainò, S., Rando, R., Razzaque, S., Regeard, M., Reimer, A., Reimer, O., Reisenegger, A., Rhode, W., Ribeiro, D., Ribó, M., Ricci, C., Richtler, T., Rico, J., Rieger, F., Riitano, L., Rizi, V., Roache, E., Fernandez, G. Rodriguez, Frías, M. D. Rodríguez, Rodríguez-Vázquez, J. J., Romano, P., Romeo, G., Rosado, J., de Leon, A. Rosales, Rowell, G., Rudak, B., Ruiter, A. J., Rulten, C. B., Sadeh, I., Saha, L., Saito, T., Salzmann, H., Sánchez-Conde, M., Sandaker, H., Sangiorgi, P., Sano, H., Santander, M., Santos-Lima, R., Sapienza, V., Šarić, T., Sarkar, A., Sarkar, S., Saturni, F. G., Savarese, S., Scherer, A., Schiavone, F., Schipani, P., Schleicher, B., Schovanek, P., Schubert, J. L., Schwanke, U., Arroyo, M. Seglar, Seitenzahl, I. R., Sergijenko, O., Servillat, M., Siegert, T., Siejkowski, H., Siqueira, C., Sliusar, V., Slowikowska, A., Sol, H., Spencer, S. T., Spiga, D., Stamerra, A., Stanič, S., Starecki, T., Starling, R., Stawarz, Ł., Steppa, C., Hatlen, E. Sæther, Stolarczyk, T., Strišković, J., Suda, Y., Świerk, P., Tajima, H., Tak, D., Takahashi, M., Takeishi, R., Tavernier, T., Tejedor, L. A., Terauchi, K., Teshima, M., Testa, V., Tian, W. W., Tibaldo, L., Tibolla, O., Peixoto, C. J. Todero, Torradeflot, F., Torres, D. F., Tosti, G., Tothill, N., Toussenel, F., Tramacere, A., Travnicek, P., Tripodo, G., Trois, A., Truzzi, S., Tutone, A., Vaclavek, L., Vacula, M., Vallania, P., Vallés, R., van Eldik, C., van Scherpenberg, J., Vandenbroucke, J., Vassiliev, V., Acosta, M. Vázquez, Vecchi, M., Ventura, S., Vercellone, S., Verna, G., Viana, A., Viaux, N., Vigliano, A., Vignatti, J., Vigorito, C. F., Villanueva, J., Visentin, E., Vitale, V., Vodeb, V., Voisin, V., Voitsekhovskyi, V., Vorobiov, S., Voutsinas, G., Vovk, I., Vuillaume, T., Wagner, S. J., Walter, R., White, M., White, R., Wierzcholska, A., Will, M., Williams, D. A., Wohlleben, F., Wolter, A., Yamamoto, T., Yang, L., Yoshida, T., Yoshikoshi, T., Zaharijas, G., Zampieri, L., Sanchez, R. Zanmar, Zavrtanik, D., Zavrtanik, M., Zdziarski, A. A., Zech, A., Zhang, W., Zhdanov, V. I., Ziętara, K., Živec, M., and Zuriaga-Puig, J.

Subjects
High Energy Physics - Phenomenology, Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Experiment
Abstract

Monochromatic gamma-ray signals constitute a potential smoking gun signature for annihilating or decaying dark matter particles that could relatively easily be distinguished from astrophysical or instrumental backgrounds. We provide an updated assessment of the sensitivity of the Cherenkov Telescope Array (CTA) to such signals, based on observations of the Galactic centre region as well as of selected dwarf spheroidal galaxies. We find that current limits and detection prospects for dark matter masses above 300 GeV will be significantly improved, by up to an order of magnitude in the multi-TeV range. This demonstrates that CTA will set a new standard for gamma-ray astronomy also in this respect, as the world's largest and most sensitive high-energy gamma-ray observatory, in particular due to its exquisite energy resolution at TeV energies and the adopted observational strategy focussing on regions with large dark matter densities. Throughout our analysis, we use up-to-date instrument response functions, and we thoroughly model the effect of instrumental systematic uncertainties in our statistical treatment. We further present results for other potential signatures with sharp spectral features, e.g.~box-shaped spectra, that would likewise very clearly point to a particle dark matter origin., Comment: 44 pages JCAP style (excluding author list and references), 19 figures; minor changes to match published version

Published
2024
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2. Methodology for the integration of the array control and data acquisition system with array elements of the Cherenkov Telescope Array Observatory

Author

Ibsen, Jorge, Chiozzi, Gianluca, Lopez, B., Aubert, P., Baroncelli, L., Bolle, P., Bruno, P., Bulgarelli, A., Caroff, S., Castaldini, L., Conforti, V., Costa, A., David, L., De Cesare, G., de Ona Wilhelm, E., Di Piano, A., Egberts, K., Fernandez, R., Fioretti, V., Fukami, S., Garcia, E., Gasparyan, H., Germani, S., Incardona, F., Kostunin, D., Lyard, E., Maurin, G., Melkumyan, D., Munari, K., Murach, T., Muraczewski, A., Nakhjiri, N., Neise, D., Oya, I., Panebianco, G., Parmiggiani, N., Pollet, V., Sadeh, I., Sah, S., Sarkar, A., Schefer, M., Schmidt, T., Soldevila, D., Steppa, C., Tramacere, A., Valles, R., Vuillaume, T., and Werner, F.

Published
2024
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3. The first release of the Cherenkov Telescope Array Observatory array control and data acquisition software

Author

Ibsen, Jorge, Chiozzi, Gianluca, Oya, I., Aubert, P., Baroncelli, L., Bolle, P., Bruno, P., Bulgarelli, A., Caroff, S., Castaldini, L., Conforti, V., Costa, A., David, L., De Cesare, G., de Ona Wilhelmli, E., Di Piano, A., Egberts, K., Fernandez, R., Fioretti, V., Fukami, S., Garcia, E., García, E., Gasparyan, H., Germani, S., Hoischen, C., Incardona, F., Kostunin, D., Lopez, B., Lyard, E., Maurin, G., Melkumyan, D., Munari, K., Murach, T., Muraczewski, A., Nakhjiri, N., Neise, D., Panebianco, G., Parmiggiani, N., Pietriga, E., Pollet, V., Sadeh, I., Sah, S., Sarkar, A., Schefer, M., Schmidt, T., Soldevila, D., Steppa, C., Torres, D., Tramacere, A., Vallés, R., Vuillaume, T., and Werner, F.

Published
2024
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30. Thymic carcinosarcoma with melanocytic differentiation in a dog.

Author

Pollet V, Picavet PP, Heimann M, and Hamaide A

Subjects
Animals, Dogs, Female, Fatal Outcome, Melanocytes pathology, Dog Diseases pathology, Dog Diseases surgery, Dog Diseases diagnosis, Carcinosarcoma veterinary, Carcinosarcoma pathology, Carcinosarcoma surgery, Carcinosarcoma diagnosis, Thymus Neoplasms veterinary, Thymus Neoplasms surgery, Thymus Neoplasms pathology, Thymus Neoplasms diagnosis
Abstract

Carcinosarcomas are very rare tumors in dogs. Although carcinosarcomas with melanocytic differentiation arising from organs other than the thymus have been described in humans, this type of tumor has not been reported in dogs in any part of the body. We observed such a tumor in the cranial mediastinum of an 11-year-old spayed female dachshund. The dog was admitted to the clinic because of coughing, sporadic regurgitation, and dyspnea. Thoracic ultrasonography and computed tomography revealed a large mediastinal mass that was surgically removed via sternotomy. The tumor was of thymic origin and demonstrated 3 distinct components: an epithelial component positive for pancytokeratin (AE1/AE3) and high molecular weight cytokeratin (CK5/CK6) with some cystic spaces; a mesenchymal component positive for vimentin; and in association with the epithelial part, a minor melanocytic component positive for Melan A. Histologic metastasis of the epithelial and melanocytic components was present within a tracheobronchial lymph node. The dog died 105 d after surgery, after an episode of acute dyspnea. Key clinical message: To the authors' knowledge, this is the first report of thymic carcinosarcoma with melanocytic differentiation., (Copyright and/or publishing rights held by the Canadian Veterinary Medical Association.)

Published
2024

31. The Successful Use of an Ultrasound-Guided Mid-Femur Sciatic Nerve Block in a Juvenile Emu ( Dromaius novaehollandiae ) under General Anaesthesia.

Author

Tutunaru AC, Morata DA, and Pollet V

Abstract

The current case report describes a successful ultrasound-guided mid-femur sciatic nerve block in an emu. A 2-month-old emu suffering from acute-onset lameness was referred to the University Clinic of Liège, where he was diagnosed with a lateral luxation of the Achilles tendon on both hind limbs. Two surgical procedures were performed for treatment. Both surgical procedures were performed under general anaesthesia with butorphanol, ketamine, midazolam and isoflurane in oxygen. The anaesthesia was continuously monitored. An ultrasound-guided sciatic nerve block was performed to prevent and treat surgically induced nociception. The technique was adapted from what is already described in other species. Levobupivacaine was injected perineurally under ultrasound-guidance. Intraoperative nociception was assessed based on the heart rate and mean arterial pressure changes. The recovery was uneventful and with no clinical signs of postoperative pain.

Published
2024
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32. Effect of the surface geometry of uncemented acetabular cups on primary stability in a model of uncemented total hip replacement in dogs.

Author

Pollet V, Viguier E, and Cachon T

Abstract

Objective: To compare the in vitro stability of acetabular cups with peripherally reinforced fixation in a model of uncemented total hip replacement in dogs., Sample: 63 polyurethane foam blocks and 3 acetabular implant designs: hemiellipsoidal (Model A) and 2 models with equatorial peripheral fins (Model B with 1 level and Model C with 2 levels of fins)., Methods: 2 loading patterns-edge loading and push-out tests-were performed until failure and peak forces were recorded. Implantation behavior was visually assessed and the required seating force was assessed using a force-displacement curve., Results: Model B showed significantly lower peak force than Model A in edge loading tests with standardized impaction. In the push-out test, Model A had a greater maximal force than Models B and C, with mean maximal forces of 213.7 N, 139.4 N, and 138.9 N, respectively. In the seating force test, Models B and C required a higher force for 2-mm deep implantation (362.0 N and 361.6 N, respectively) than Model A (194.4 N), and were associated with dorsal tilting of the components., Clinical Relevance: Our results suggest that cups with a peripheral design (B, C) have less primary stability than hemiellipsoidal cups (A). Furthermore, models with peripheral fins (B, C) appeared to have incomplete seating if a higher force was not used during implantation and, therefore, the risk of malpositioning was increased. These data indicate that hemiellipsoidal cups provide the same or better initial stability and require a lower impaction force.

Published
2023
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33. Statistical Shape Modeling of US Images to Predict Hip Dysplasia Development in Infants.

Author

Bonsel JM, Gielis WP, Pollet V, Weinans HH, and Sakkers RJB

Subjects
Child, Preschool, Female, Hip Joint diagnostic imaging, Humans, Infant, Male, Orthotic Devices, Prospective Studies, Treatment Outcome, Ultrasonography, Hip Dislocation, Hip Dislocation, Congenital diagnostic imaging, Hip Dislocation, Congenital therapy
Abstract

Background The current widely applied Graf classification used on US images for developmental dysplasia of the hip in infants does not enable prediction of the development and outcome of well-centered stable dysplastic hips (Graf type II). Purpose To use statistical shape modeling on US images to identify acetabular shape characteristics of Graf type II hips, which enable prediction of the development of Graf type II hips, and to identify which hips benefit from Pavlik harness treatment. Materials and Methods In this secondary analysis of a prospective multicenter randomized trial on treatment of 104 infants aged 3-4 months with Graf type IIb or IIc hip dysplasia conducted between 2009 and 2015, a statistical shape model was developed on baseline US images. With multivariable logistic regression adjusted for infant sex and treatment (Pavlik harness treatment vs active observation), shape modes were correlated with the outcomes of persistent hip dysplasia on US images (α angle <60°) after 12-week follow-up and residual hip dysplasia on pelvic radiographs (Tönnis classification: acetabular index greater than 2 standard deviations) around 1 year of age. An interaction term (treatment with mode) was used to investigate if this result depended on treatment. Results Baseline US images were available in 97 infants (mean age, 3.37 years ± 0.43 [standard deviation]; 89 [92%] girls; 90 cases of Graf type IIb hip dysplasia; 52 cases treated with Pavlik harness). Shape modes 2 and 3 of the statistical shape modeling were associated with persistent hip dysplasia on US images (odds ratio [OR] = 0.43; P = .007 and OR = 2.39; P = .02, respectively). Mode 2 was also associated with residual hip dysplasia on pelvic radiographs (OR = 0.09; P = .002). The interaction term remained significant after multivariable analysis, indicating that Pavlik harness treatment was beneficial in patients with negative mode 2 values (OR = 12.46; P = .01). Conclusion Statistical shape modeling of US images of infants with Graf type II dysplastic hips predicted which hips developed to normal or remained dysplastic and identified hips that benefited from Pavlik harness treatment. © RSNA, 2022.

Published
2022
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34. Morphological variants to predict outcome of avascular necrosis in developmental dysplasia of the hip.

Author

Pollet V, Bonsel J, Ganzeboom B, Sakkers R, and Waarsing E

Subjects
Child, Child, Preschool, Developmental Dysplasia of the Hip diagnostic imaging, Female, Femur Head Necrosis diagnostic imaging, Humans, Infant, Male, Retrospective Studies, Developmental Dysplasia of the Hip therapy, Femur Head abnormalities, Femur Head Necrosis etiology
Abstract

Aims: The most important complication of treatment of developmental dysplasia of the hip (DDH) is avascular necrosis (AVN) of the femoral head, which can result in proximal femoral growth disturbances leading to pain, dysfunction, and eventually to early onset osteoarthritis. In this study, we aimed to identify morphological variants in hip joint development that are predictive of a poor outcome., Methods: We retrospectively reviewed all patients who developed AVN after DDH treatment, either by closed and/or open reduction, at a single institution between 1984 and 2007 with a minimal follow-up of eight years. Standard pelvis radiographs obtained at ages one, two, three, five, and eight years, and at latest follow-up were retrieved. The Bucholz-Ogden classification was used to determine the type of AVN on all radiographs. Poor outcome was defined by Severin classification grade 3 or above on the latest follow-up radiographs and/or the need for secondary surgery. With statistical shape modelling, we identified the different shape variants of the hip at each age. Logistic regression analysis was used to associate the different modes or shape variants with poor outcome., Results: In all, 135 patients with AVN were identified, with a minimum of eight years of follow-up. Mean age at time of surgery was 7.0 months (SD 0.45), and mean follow-up was 13.3 years (SD 3.7). Overall, 46% had AVN type 1 while 54% type 2 or higher. More than half of the patients (52.6%) had a poor outcome. We found 11 shape variants that were significantly associated with a poor outcome. These shape variants were predominantly linked to AVN type 2 or higher., Conclusion: Specific morphological characteristics on pelvis radiographs of AVN hips were predictive for poor outcome, at a very young age. There was an overall stronger association to Bucholz-Ogden types 2-3-4 with the exception of two modes at age two and five years, linked to AVN type 1. Cite this article: Bone Joint J  2021;103-B(5):999-1004.

Published
2021
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35. Comparison of hydroalcoholic rubbing and conventional chlorhexidine scrubbing for aseptic skin preparation in dogs.

Author

Asimus E, Palierne S, Blondel M, Pollet V, Ferran A, Bousquet-Melou A, Rousselot JF, and Autefage A

Subjects
Animals, Bacteria drug effects, Chlorhexidine pharmacology, Colony Count, Microbial veterinary, Dogs, Humans, Skin microbiology, Soaps, Alcohols pharmacology, Anti-Infective Agents, Local pharmacology, Chlorhexidine analogs & derivatives
Abstract

Objective: To compare preparation time, ease of application, and elimination of skin contamination of 3 skin preparation methods for asepsis., Study Design: Experimental study., Animals: Healthy dogs (n = 6) with no clinical signs of skin disease., Methods: Three sites on each dog were randomly allocated to 1 of 3 preparation protocols for asepsis: (1) 5 scrubbings with chlorhexidine gluconate and rinsing (CHXG), (2) washing with mild soap prior to 3 rubbings with hydroalcoholic solution (soap-HAR), or (3) 3 rubbings with hydroalcoholic solution (HAR). The duration of each method of skin preparation was recorded. A Count-Tact agar plate was placed in the center of each site before, immediately after, 1 hour after, and 3 hours after antiseptic application. Plates were cultured, and colony forming units (CFU) were counted., Results: Skin preparation lasted an average of 375 seconds for CHXG, 240 seconds for soap-HAR, and 190 seconds for HAR (P = .00049). Nine CFU (median) were cultured from the skin prior to preparation, with no difference between sites on any animal or for any method. Colony forming units were not detected at any time on any site in any dog after antiseptic application., Conclusion: Rubbing with hydroalcoholic (HA) solution was as effective as CHXG and prevented bacterial growth for at least 3 hours under these experimental conditions. Rubbing with hydroalcoholic solution was also faster and easier to perform., Clinical Significance: Because there is currently no known resistance to HA solution, preparation of the surgical site with HAR should be considered to prevent the emergence of bacterial resistance to chlorhexidine as well as potential cross-resistances to antibiotics. Transfer to clinical animals requires additional investigation., (© 2019 The American College of Veterinary Surgeons.)

Published
2019
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36. The Dutch version of the Oxford Ankle and Foot Questionnaire for Children: Useful for evaluation of pediatric foot problems in groups.

Author

Burger E, Selles R, van Nieuwkasteele S, Bessems G, Pollet V, Hovius S, and van Nieuwenhoven C

Subjects
Activities of Daily Living, Adolescent, Child, Child, Preschool, Female, Humans, Male, Netherlands, Reproducibility of Results, Ankle Joint physiopathology, Foot physiopathology, Patient Reported Outcome Measures, Surveys and Questionnaires, Translating
Abstract

Background: The purpose of this study is to develop a Dutch version of the Oxford Ankle and Foot Questionnaire for Children (OxAFQ-c) to allow evaluation of pediatric foot care., Methods: The OxAFQ-c was translated into Dutch, according to the ISPOR-guidelines. Children with different foot and ankle complaints completed the OxAFQ-c at baseline, after two weeks, and after 4-6 months. Measurement properties were assessed in terms of reliability, responsiveness, and construct validity., Results: Test-retest reliability showed moderate intraclass correlation coefficients. Bland-Altman plots showed wide limits of agreement. After 4-6 months, the group that experienced improvement also showed improved questionnaire outcomes, indicating responsiveness. Moderate correlation between the OxAFQ-c and the Kidscreen and foot-specific VAS-scores were observed, indicating moderate construct validity., Conclusions: The Dutch OxAFQ-c showed moderate to good measurement properties. However, because we observed limited sensitivity to changes and wide limits of agreement in individual patients, we think the questionnaire should only be used in groups., (Copyright © 2017 European Foot and Ankle Society. Published by Elsevier Ltd. All rights reserved.)

Published
2019
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37. A long term follow-up study of the development of hip disease in Mucopolysaccharidosis type VI.

Author

Oussoren E, Bessems JHJM, Pollet V, van der Meijden JC, van der Giessen LJ, Plug I, Devos AS, Ruijter GJG, van der Ploeg AT, and Langeveld M

Subjects
Acetabulum abnormalities, Adult, Coxa Magna diagnosis, Female, Femur abnormalities, Femur Head abnormalities, Follow-Up Studies, Hip Dislocation diagnosis, Hip Joint diagnostic imaging, Hip Joint pathology, Humans, Male, Mucopolysaccharidosis VI diagnosis, N-Acetylgalactosamine-4-Sulfatase genetics, Pelvis abnormalities, Pelvis diagnostic imaging, Prospective Studies, Time Factors, Coxa Magna etiology, Hip Dislocation etiology, Mucopolysaccharidosis VI complications
Abstract

Hip problems in Mucopolysaccharidosis type VI (MPS VI) lead to severe disability. Lack of data on the course of hip disease in MPS VI make decisions regarding necessity, timing and type of surgical intervention difficult. We therefore studied the development of hip pathology in MPS VI patients over time. Data were collected as part of a prospective follow-up study. Standardized supine AP pelvis and frog leg lateral radiographs of both hips were performed yearly or every 2years. Image assessment was performed quantitatively (angle measurements) and qualitatively (hip morphology). Clinical burden of hip disease was evaluated by physical examination, six minute walking test (6MWT) and a questionnaire assessing pain, wheelchair-dependency and walking distance. A total of 157 pelvic radiographs of 14 ERT treated MPS VI patients were evaluated. Age at first image ranged from 2.0 to 21.1years. Median follow up duration was 6.8years. In all patients, even in the youngest, the acetabulum and os ilium were dysplastic. Coverage of the femoral head by the acetabulum improved over time, but remained insufficient. While the femoral head appeared normal in the radiographs at young age, the ossification pattern became abnormal in all patients over time. In all patients the distance covered in the 6MWT was reduced (median Z scores -3.3). Twelve patients had a waddling gait. Four patients were partially wheelchair-dependent and ten patients had limitations in their maximum walking distance. In conclusion, clinically significant hip abnormalities develop in all MPS VI patients from very early in life, starting with deformities of the os ilium and acetabulum. Femoral head abnormalities occur later, most likely due to altered mechanical forces in combination with epiphyseal abnormalities due to glycosaminoglycan storage. The final shape and angle of the femoral head differs significantly between individual MPS VI patients and is difficult to predict., (Copyright © 2017 Elsevier Inc. All rights reserved.)

Published
2017
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38. Relative Risk and Incidence for Developmental Dysplasia of the Hip.

Author

Pollet V, Percy V, and Prior HJ

Subjects
Cohort Studies, Early Diagnosis, Female, Hip Dislocation, Congenital diagnosis, Humans, Incidence, Infant, Infant, Newborn, Male, Manitoba epidemiology, Neonatal Screening methods, Retrospective Studies, Risk, Risk Factors, Hip Dislocation, Congenital epidemiology
Abstract

Objective: To determine the incidence and associated risk factors of developmental dysplasia of the hip (DDH) in a modern population without universal screening., Study Design: Children with DDH were identified from the Manitoba Centre for Health Policy's Data Repository by the use of International Classification of Diseases diagnosis codes as well as physician billing tariffs for surgical procedures for DDH for all children born between 1995 and 2012. To identify the outpatient-treated patients, ultrasound scans and radiographic imaging for DDH were reviewed for 2004-2012. Overall incidence was calculated on the basis of birth rate for the province per year. Relative risks of sex, first born, breech position, clubfoot deformity, multiple gestations, as well as regional health areas were analyzed with χ 2 tests., Results: We identified 1716 cases of DDH of 258 499 newborns. The incidence of DDH was calculated at 6.6/1000 newborns. Late-presenting DDH was detected in 2.2/1000 newborns. Female first-born children, clubfoot deformity, and breech position were associated significantly with an increased risk. Children with DDH born in rural areas of the Northern and Central part of Manitoba presented at a later age than those who are born in the urban areas (P < .0001) CONCLUSION: This study shows the need for improved early detection and awareness at well-baby clinics of risk factors and regional differences for DDH., (Copyright © 2016 Elsevier Inc. All rights reserved.)

Published
2017
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39. Prefrontal cortical activity associated with visual stimulus categorization in non-human primates measured with near-infrared spectroscopy.

Author

Lee YA, Pollet V, Kato A, and Goto Y

Subjects
Animals, Area Under Curve, Female, Macaca, Neuropsychological Tests, Photic Stimulation, Psychiatric Status Rating Scales, Brain Mapping, Hemoglobins metabolism, Prefrontal Cortex physiology, Spectroscopy, Near-Infrared
Abstract

In biomedical research of brain dysfunction in psychiatric disorders, utilization of animal models is essential. However, translation of findings in animal models into the realm of human clinical conditions requires reliable biomarkers that are assessed with the methods mutually employed in animal models and human patients. Near-infrared spectroscopy (NIRS) is a functional neuroimaging technique that has now been widely utilized in human basic and clinical research. However, its application to animal models has been barely conducted. In this study, we developed the method to measure neural activity in the cortex of Japanese macaques using NIRS, and examined cortical responses to presentation of a set of visual stimuli that were categorized into four different groups (flower, monkey, snake, food). Prefrontal cortical (PFC) oxy- and deoxy-hemoglobin changes were found to reliably distinguish the categories of these visual stimuli. The results suggest that cortical activity measurement with NIRS in primates can be a valuable model for identifying biomarkers associated with psychiatric disorders., (Copyright © 2016 Elsevier B.V. All rights reserved.)

Published
2017
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40. Os trigonum syndrome.

Author

Wybenga JM, Biemans JM, and Pollet V

Subjects
Adult, Ankle diagnostic imaging, Female, Humans, Magnetic Resonance Imaging, Pain, Radiography, Syndrome, Foot Diseases diagnosis, Talus
Published
2008

41. Stress fracture of the acetabular roof. Case report and value of MRI.

Author

Pollet V, Bellemans M, Damry N, and Lamoureux J

Subjects
Acetabulum pathology, Biopsy, Bone Marrow pathology, Child, Diagnosis, Differential, Follow-Up Studies, Humans, Male, Acetabulum injuries, Fractures, Stress diagnosis, Magnetic Resonance Imaging
Abstract

The authors report the case of an 11-year-old boy with pain in the left leg without history of recent trauma. The diagnosis of a stress fracture of the acetabulum was made based on MRI and bone marrow biopsy. They discuss the role of MRI in the diagnosis of a stress fracture.

Published
1999

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