20 results on '"Polley, M. Y."'
Search Results
2. Abstract P3-08-01: Characteristics, outcomes and prognostic factors of luminal androgen receptor (LAR) triple-negative breast cancer (TNBC)
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Leon-Ferre, RA, primary, Polley, M-Y, additional, Liu, H, additional, Kalari, KR, additional, Boughey, JC, additional, Liu, MC, additional, Cafourek, V, additional, Negron, V, additional, Ingle, JN, additional, Thompson, KJ, additional, Tang, X, additional, Barman, P, additional, Carlson, E, additional, Visscher, DW, additional, Carter, JC, additional, Couch, FJ, additional, and Goetz, MP, additional
- Published
- 2019
- Full Text
- View/download PDF
3. Abstract PD4-05: Molecular breast imaging and tomosynthesis to eliminate the reservoir of undetected cancer in dense breasts: The Density MATTERS trial
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Rhodes, D, primary, Hunt, K, additional, Conners, A, additional, Zingula, S, additional, Whaley, D, additional, Ellis, R, additional, Gasal Spilde, J, additional, Mehta, R, additional, Polley, M-Y, additional, O'Connor, M, additional, and Hruska, C, additional
- Published
- 2019
- Full Text
- View/download PDF
4. Abstract GS3-02: Invasive disease-free survival and gene expression signatures in CALGB (Alliance) 40601, a randomized phase III neoadjuvant trial of dual HER2-targeting with lapatinib added to chemotherapy plus trastuzumab
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Krop, IE, primary, Hillman, D, additional, Polley, M-Y, additional, Tanioka, M, additional, Parker, J, additional, Huebner, L, additional, Henry, NL, additional, Tolaney, SM, additional, Dang, C, additional, Harris, L, additional, Berry, DA, additional, Perou, CM, additional, Partridge, A, additional, Winer, EP, additional, and Carey, LA, additional
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- 2018
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5. Abstract P3-05-06: Prognostic value of the neutrophil-to-lymphocyte ratio (NLR) and its relation to stromal tumor infiltrating lymphocytes (sTILs) in triple negative breast cancer (TNBC)
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Leon-Ferre, RA, primary, Polley, M-Y, additional, Liu, H, additional, Gilbert, J, additional, Cafourek, V, additional, Hillman, D, additional, Negron, V, additional, Boughey, JC, additional, Liu, MC, additional, Ingle, JN, additional, Kalari, K, additional, Couch, FJ, additional, Visscher, DW, additional, and Goetz, MP, additional
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- 2018
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- View/download PDF
6. Statistical and Practical Considerations for Clinical Evaluation of Predictive Biomarkers
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Polley, M.-Y. C., primary, Freidlin, B., additional, Korn, E. L., additional, Conley, B. A., additional, Abrams, J. S., additional, and McShane, L. M., additional
- Published
- 2013
- Full Text
- View/download PDF
7. C-C4-02: Using a Natural Language Processor to Remove All Elements of Personal Health Information (PHI) to Deidentify Clinical Annotations for the Specimen Retrieval System (SRS)
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Glass, A., primary, Taube, S., additional, McMurry, A., additional, Eddy, C., additional, La Chance, P.-A., additional, McShane, L., additional, Polley, M.-Y., additional, and Kohane, I., additional
- Published
- 2011
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8. Phase II and pharmacogenomics study of enzastaurin plus temozolomide during and following radiation therapy in patients with newly diagnosed glioblastoma multiforme and gliosarcoma
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Butowski, N., primary, Chang, S. M., additional, Lamborn, K. R., additional, Polley, M.-Y., additional, Pieper, R., additional, Costello, J. F., additional, Vandenberg, S., additional, Parvataneni, R., additional, Nicole, A., additional, Sneed, P. K., additional, Clarke, J., additional, Hsieh, E., additional, Costa, B. M., additional, Reis, R. M., additional, Hristova-Kazmierski, M., additional, Nicol, S. J., additional, Thornton, D. E., additional, and Prados, M. D., additional
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- 2011
- Full Text
- View/download PDF
9. Inhibition of PI3K/mTOR pathways in glioblastoma and implications for combination therapy with temozolomide
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Prasad, G., primary, Sottero, T., additional, Yang, X., additional, Mueller, S., additional, James, C. D., additional, Weiss, W. A., additional, Polley, M.-Y., additional, Ozawa, T., additional, Berger, M. S., additional, Aftab, D. T., additional, Prados, M. D., additional, and Haas-Kogan, D. A., additional
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- 2011
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- View/download PDF
10. Serial analysis of imaging parameters in patients with newly diagnosed glioblastoma multiforme
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Li, Y., primary, Lupo, J. M., additional, Polley, M.-Y., additional, Crane, J. C., additional, Bian, W., additional, Cha, S., additional, Chang, S., additional, and Nelson, S. J., additional
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- 2011
- Full Text
- View/download PDF
11. Assessment of perfusion MRI-derived parameters in evaluating and predicting response to antiangiogenic therapy in patients with newly diagnosed glioblastoma
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Essock-Burns, E., primary, Lupo, J. M., additional, Cha, S., additional, Polley, M.-Y., additional, Butowski, N. A., additional, Chang, S. M., additional, and Nelson, S. J., additional
- Published
- 2010
- Full Text
- View/download PDF
12. Angiogenesis and Invasion
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Fishman, R. A., primary, Happ, E., additional, Stevens, T., additional, Kunschner, L., additional, Jaworski, D. M., additional, Stradecki, H. M., additional, Penar, P. L., additional, Pendlebury, W. W., additional, Pennington, C. J., additional, Edwards, D. R., additional, Broaddus, W. C., additional, Fillmore, H. L., additional, Mukherjee, J., additional, Hawkins, C., additional, Guha, A., additional, Pioli, P. D., additional, Milani, S., additional, Linskey, M. E., additional, Zhou, Y.-H., additional, Marchetti, V., additional, Barnett, F., additional, Wang, M., additional, Scheppke, L., additional, Sanchez-Cespedes, J., additional, De Rossi, C., additional, Nemerow, G., additional, Torbett, B., additional, Friedlander, M., additional, Goldlust, S. A., additional, Singer, S., additional, DeAngelis, L. M., additional, Lassman, A. B., additional, Nolan, C. P., additional, Yang, S.-H., additional, Lee, S. W., additional, Chen, Z.-p., additional, Liu, X.-m., additional, Wojton, J. A., additional, Chu, Z., additional, Qi, X., additional, Kaur, B., additional, Hu, Y., additional, Siegel, E., additional, Ro, D. I., additional, Marlon, S., additional, Hsu, N., additional, Milani, S. N., additional, Mohan, S., additional, Yu, L., additional, Hess, K. R., additional, Liu, Y., additional, Carson-Walter, E., additional, Walter, K., additional, Raghu, H., additional, Gondi, C. S., additional, Gujrati, M., additional, Dinh, D. H., additional, Rao, J. S., additional, Narayana, A., additional, Kunnakkat, S. D., additional, Medabalmi, P., additional, Golfinos, J., additional, Parker, E., additional, Knopp, E., additional, Zagzag, D., additional, Gruber, D., additional, Gruber, M. L., additional, Burrell, K., additional, Jelveh, S., additional, Lindsey, P., additional, Hill, R., additional, Zadeh, G., additional, Ivkovic, S., additional, Beadle, C., additional, Massey, S. C., additional, Swanson, K. R., additional, Canoll, P., additional, Rosenfeld, S. S., additional, McAllister, S., additional, Soroceanu, L., additional, Pakdel, A., additional, Limbad, C., additional, Adrados, I., additional, Desprez, P.-Y., additional, Nakada, M., additional, Nambu, E., additional, Furuyama, N., additional, Yoshida, Y., additional, Kita, D., additional, Hayashi, Y., additional, Hamada, J.-i., additional, Seyed Sadr, M., additional, Maret, D., additional, Seyed Sadr, E., additional, Siu, V., additional, Alshami, J., additional, Denault, J.-S., additional, Faury, D., additional, Jabado, N., additional, Nantel, A., additional, Del Maestro, R., additional, Perretta, D., additional, Nagaiah, G., additional, Almubarak, M., additional, Torres-Trejo, A., additional, Newton,, M., additional, Willey, P., additional, Altaha, R., additional, Murphy, S. F., additional, Banasiak, M., additional, Yee, G.-T., additional, Wotoczek-Obadia, M., additional, Tran, Y., additional, Prak, A., additional, Albright, R., additional, Mullan, M., additional, Paris, D., additional, Brem, S., additional, Yang, Y.-P., additional, Ennis, M., additional, Tran, N., additional, Symons, M., additional, Najbauer, J., additional, Huszthy, P. C., additional, Garcia, E., additional, Metz, M. Z., additional, Gutova, M., additional, Frank, R. T., additional, Miletic, H., additional, Glackin, C. A., additional, Barish, M. E., additional, Bjerkvig, R., additional, Aboody, K. S., additional, Clump, D. A., additional, Engh, J. A., additional, Mintz, A. H., additional, Cunnick, J., additional, Flynn, D. C., additional, Clark, A. J., additional, Butowski, N. A., additional, Chang, S. M., additional, Prados, M. D., additional, Clarke, J., additional, Polley, M.-Y. C., additional, Sughrue, M. E., additional, McDermott, M. W., additional, Parsa, A. T., additional, Berger, M. S., additional, Aghi, M. K., additional, Megyesi, J. F., additional, Costello, P., additional, Macdonald, W., additional, Dyer, E., additional, Macdonald, D., additional, Hammond, R., additional, Kalache, Y., additional, Easaw, J., additional, McIntyre, J., additional, Williams, S. C., additional, Karajannis, M. A., additional, Chiriboga, L., additional, von Deimling, A., additional, Ajlan, A., additional, Husaine, S., additional, Petrecca, K., additional, Magnus, N., additional, Garnier, D., additional, Meehan, B., additional, and Rak, J., additional
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- 2010
- Full Text
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13. Cell Biology and Signaling
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Long, P. M., primary, Wesley, U. V., additional, Jaworski, D. M., additional, Rana, M., additional, Kiehl, T.-R., additional, So, K., additional, Gould, P., additional, Ajewung, N., additional, Kamnasaran, D., additional, Emmett, M. R., additional, Wang, X., additional, Marshall, A. G., additional, Ji, Y., additional, Fokt, I., additional, Skora, S., additional, Conrad, C. A., additional, Priebe, W., additional, Zhu, H., additional, Cao, X., additional, Keir, S., additional, Ali-Osman, F., additional, Lo, H.-W., additional, Da Fonseca, C. O., additional, Arun, V., additional, Wiley, J. C., additional, Kaur, H., additional, Guha, A., additional, Fenton, K., additional, Abdelwahab, M. G., additional, Stafford, P., additional, Rho, J. M., additional, Preul, M. C., additional, Scheck, A. C., additional, Brossier, N. M., additional, Carroll, S. L., additional, Gajadhar, A., additional, Mukherjee, J., additional, Wolf, A., additional, Hawkins, C., additional, Costa, P., additional, Cardoso, A. L. C., additional, de Almeida, L. P., additional, de Lima, M. C. P., additional, Canoll, P., additional, Bruce, J., additional, Lavon, I., additional, Granit, A., additional, Einstein, O., additional, Ben-Hur, T., additional, Siegal, T., additional, Pang, J. C., additional, Poon, W. S., additional, Zhou, L., additional, Ng, H.-K., additional, Rovin, R. A., additional, Lawrence, J. E., additional, Segula, J. J., additional, Winn, R. J., additional, Patil, S., additional, Burzynski, S. R., additional, Mrowczynski, E., additional, Grela, K., additional, Cheng, S., additional, Liu, K., additional, Feng, H., additional, Bacho, R., additional, Kazlauskas, A., additional, Smith, E. M., additional, Symes, K., additional, Hu, B., additional, Lee, C. Y., additional, Fotovati, A., additional, Dunn, S. E., additional, Proescholdt, M. A., additional, Storr, E.-M., additional, Lohmeier, A., additional, Brawanski, A., additional, Jarzynka, M. J., additional, Ravichandran, K. S., additional, Vuori, K., additional, Tang, C., additional, Nshikawa, R., additional, Johns, T. G., additional, Furnari, F. B., additional, Cavenee, W. K., additional, Zhong, J., additional, O'Neill, G. M., additional, Deleyrolle, L. P., additional, Rahman, M., additional, Dunbar, E. M., additional, Caldeira, M. A., additional, Reynolds, B. A., additional, Liu, X., additional, Yacyshyn, S., additional, Dasgupta, B., additional, Han, X., additional, Yang, X., additional, Wheeler, C. G., additional, Filippova, N., additional, Langford, C. P., additional, Ding, Q., additional, Fathallah, H. M., additional, Gillespie, G. Y., additional, Nabors, L. B., additional, Davidson, T. B., additional, Gortalum, F., additional, Ji, L., additional, Engell, K., additional, Sposto, R., additional, Asgharzadeh, S., additional, Erdreich-Epstein, A., additional, Lawn, S. O., additional, Weiss, S., additional, Senger, D., additional, Forsyth, P., additional, Latha, K., additional, Chumbalkar, V., additional, Li, M., additional, Gururaj, A., additional, Hwang, Y., additional, Maywald, R., additional, Dakeng, S., additional, Dao, L., additional, Baggerly, K., additional, Sawaya, R., additional, Aldape, K., additional, Cavenee, W., additional, Furnari, F., additional, Bogler, O., additional, Arumugam, J., additional, Sim, H., additional, Pineda, C. A., additional, Pan, Y., additional, Viapiano, M. S., additional, Van Schaick, J. A., additional, Akagi, K., additional, Burkett, S., additional, DiFabio, C., additional, Tuskan, R., additional, Walrath, J., additional, Reilly, K., additional, Dai, B., additional, Jing, Z., additional, Kang, S.-H., additional, Li, D., additional, Xie, K., additional, Huang, S., additional, Gong, X., additional, Vuong, Y., additional, Bota, D. A., additional, Stegh, A. H., additional, Inda, M.-d.-M., additional, Bonavia, R., additional, Mukasa, A., additional, Narita, Y., additional, Sah, D., additional, Vandenberg, S., additional, Brennan, C., additional, Johns, T., additional, Bachoo, R., additional, Hadwiger, P., additional, Tan, P., additional, DePinho, R., additional, Kusne, Y., additional, Meerson, A., additional, Rushing, E. J., additional, Yang, W., additional, McDonough, W., additional, Kislin, K., additional, Loftus, J. C., additional, Berens, M., additional, Lu, Z., additional, Ghosh, S., additional, Verma, A., additional, Zhou, H., additional, Chin, S., additional, Bruggers, C., additional, Kestle, J., additional, Khatua, S., additional, Broekman, M. L., additional, Maas, N. S., additional, Skog, J., additional, Breakefield, X. O., additional, Sena-Esteves, M., additional, de Vrij, J., additional, Lamfers, M., additional, Maas, N., additional, Dirven, C., additional, Esteves, M., additional, Broekman, M., additional, Chidambaram, A., additional, Dumur, C. I., additional, Graf, M., additional, Vanmeter, T. E., additional, Fillmore, H. L., additional, Broaddus, W. C., additional, Silber, J., additional, Ozawa, T., additional, Kastenhuber, E., additional, Djaballah, H., additional, Holland, E. C., additional, Huse, J. T., additional, Agnihotri, S., additional, Munoz, D., additional, Han, J. E., additional, Albesiano, E., additional, Pradilla, G., additional, Lim, M., additional, Alshami, J., additional, Sabau, C., additional, Seyed Sadr, M., additional, Anan, M., additional, Seyed Sadr, E., additional, Siu, V., additional, Del Maestro, R., additional, Trinh, G., additional, Le, P., additional, Petrecca, K., additional, Sonabend, A. M., additional, Soderquist, C., additional, Lei, L., additional, Guarnieri, P., additional, Leung, R., additional, Yun, J., additional, Sisti, J., additional, Castelli, M., additional, Bruce, S., additional, Bruce, R., additional, Ludwig, T., additional, Rosenfeld, S., additional, Bruce, J. N., additional, Phillips, J. J., additional, Huillard, E., additional, Polley, M.-Y., additional, Rosen, S. D., additional, Rowitch, D. H., additional, Werb, Z., additional, Sarkar, C., additional, Jha, P., additional, Pathak, P., additional, Suri, V., additional, Sharma, M. C., additional, Chattopadhyay, P., additional, Chosdol, K., additional, Suri, A., additional, Gupta, D., additional, Mahapatra, A. K., additional, Kapoor, G. S., additional, Zhan, Y., additional, Boockvar, J. A., additional, O'Rourke, D. M., additional, Kwatra, M. M., additional, Kim, J. W., additional, Park, C.-K., additional, Han, J. H., additional, Park, S. H., additional, Kim, S.-K., additional, Jung, H.-W., additional, Narayanan, R., additional, Levin, B. S., additional, Maeder, M. L., additional, Joung, J. K., additional, Nutt, C. L., additional, Louis, D. N., additional, Dudley, A., additional, Jayaram, P., additional, Pei, Z., additional, Shi, X., additional, Laterra, J., additional, Watkins, P. A., additional, Mawrin, C., additional, Rempel, S. A., additional, McClung, H. M., additional, McFarland, B. C., additional, Nozell, S. E., additional, Huszar, D., additional, Benveniste, E. N., additional, Burton, T., additional, Eisenstat, D. D., additional, Gibson, S. B., additional, Lukiw, W. J., additional, Cui, J. G., additional, Li, Y. Y., additional, Zhao, Y., additional, Culicchia, F., additional, See, W., additional, Pieper, R., additional, Luchman, A., additional, Stechishin, O., additional, Nguyen, S., additional, Kelly, J., additional, Blough, M., additional, Cairncross, G., additional, Shah, S. R., additional, Mohyeldin, A., additional, Adams, H., additional, Garzon-Muvdi, T., additional, Aprhys, C., additional, Quinones-Hinojosa, A., additional, Weeks, A. C., additional, Restrepo, A., additional, Ivanchuk, S., additional, Smith, C., additional, Rutka, J. T., additional, Sengupta, R., additional, Yang, L., additional, Burbassi, S., additional, Zhang, B., additional, Markant, S. L., additional, Yang, Z.-j., additional, Meucci, O., additional, Wechsler-Reya, R. J., additional, Rubin, J. B., additional, Wykosky, J., additional, Chin, L., additional, Auvergne, R. M., additional, Sim, F. J., additional, Wang, S., additional, Chandler-Militello, D., additional, Burch, J., additional, Li, X., additional, Bennet, A., additional, Mohile, N., additional, Pilcher, W., additional, Walter, K., additional, Johnson, M., additional, Achanta, P., additional, Natesan, S., additional, Goldman, S. A., additional, Beauchamp, A. S., additional, Gibo, D. M., additional, Debinski, W., additional, Jiang, H., additional, Martin, V., additional, Gomez-Manzano, C., additional, Johnson, D. G., additional, Alonso, M., additional, White, E. J., additional, Xu, J., additional, McDonnell, T., additional, Shinojima, N., additional, Fueyo, J., additional, Sandhya Rani, M. R., additional, Huang, P., additional, Prayson, R., additional, Hedayat, H., additional, Sloan, A. E., additional, Novacki, A., additional, Ahluwalia, M. S., additional, Tipps, R., additional, Gladson, C. L., additional, Liu, J.-L., additional, Mao, Z., additional, Yung, W. K. A., additional, Bhat, K., additional, Salazar, K., additional, Balasubramaniyan, V., additional, Vaillant, B., additional, Hollingsworth, F., additional, Gumin, J., additional, Diefes, K., additional, Patel, D., additional, Lang, F., additional, Colman, H., additional, Parsyan, A., additional, Shahbazian, D., additional, Alain, T., additional, Martineau, Y., additional, Petroulakis, E., additional, Larsson, O., additional, Gkogkas, C., additional, Topisirovic, I., additional, Mathonnet, G., additional, Tettweiler, G., additional, Hellen, C., additional, Pestova, T., additional, Svitkin, Y., additional, Sonenberg, N., additional, Zerrouqi, A., additional, Pyrzynska, B., additional, Van Meir, E., additional, Twitty, G. B., additional, Hong, S. W., additional, Lee, H. K., additional, Finniss, S., additional, Xiang, C., additional, Cazacu, S., additional, Brodie, C., additional, Ginn, K. F., additional, Wise, A., additional, Farassati, F., additional, Brown, C., additional, Barish, M., additional, deCarvalho, A. C., additional, Hasselbach, L., additional, Nelson, K., additional, Lemke, N., additional, Schultz, L., additional, Mikkelsen, T., additional, Onvani, S., additional, Kongkham, P., additional, Smith, C. A., additional, Bier, A., additional, Hershkovitz, H., additional, Kahana, S., additional, Decarvalho, A., additional, Massey, S. C., additional, and Swanson, K. R., additional
- Published
- 2010
- Full Text
- View/download PDF
14. Surgical Therapies
- Author
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Kim, C.-Y., primary, Tate, M., additional, Chang, E., additional, Polley, M.-Y., additional, Berger, M., additional, Mercier, L., additional, Del Maestro, R. F., additional, Petrecca, K., additional, Collins, D. L., additional, Doglietto, F., additional, Salehi, F., additional, Ridout, R., additional, Gentili, F., additional, Zadeh, G., additional, Shrivastava, R. K., additional, Ghesani, M., additional, Sen, C., additional, Tabaee, A., additional, Lee, K. D., additional, DePowell, J. J., additional, Air, E., additional, Dwivedi, A. K., additional, McPherson, C. M., additional, Mishra, M. V., additional, Andrews, D., additional, Evans, J., additional, Glass, J., additional, Dicker, A. P., additional, Lawrence, Y. R., additional, Kirsch, M., additional, Juratli, T., additional, Meyer, K., additional, Schackert, G., additional, Cho, J. M., additional, Kim, E. H., additional, Oh, M. C., additional, Chang, J. H., additional, Kim, S. H., additional, Lee, K. S., additional, Adams, H., additional, Avendano, J., additional, Raza, S. M., additional, Olivi, A., additional, Quinones-Hinojosa, A., additional, Siu, V., additional, Seyed sadr, M., additional, Alshami, J., additional, Sabau, C., additional, Seyed sadr, E., additional, Anan, M., additional, Guiot, M.-C., additional, Samani, A., additional, Del Maestro, P., additional, Galameau, A., additional, Greaves, K., additional, Pouliot, J.-F., additional, Mangano, F., additional, Pruitt, D., additional, and Hummel, T., additional
- Published
- 2010
- Full Text
- View/download PDF
15. Radiology
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Ellingson, B. M., primary, Pope, W. B., additional, Lai, A., additional, Nghiemphu, P. L., additional, Cloughesy, T. F., additional, Juhasz, C., additional, Mittal, S., additional, Muzik, O., additional, Chugani, D. C., additional, Chakraborty, P. K., additional, Bahl, G., additional, Barger, G. R., additional, Carrillo, J. A., additional, Nghiemphu, P., additional, Tran, A., additional, Moftakhar, P., additional, Bruggers, C., additional, Moore, K., additional, Khatua, S., additional, Gumerlock, M. K., additional, Stolzenberg, E., additional, Fung, K.-M., additional, Smith, M. L., additional, Kedzierska, K., additional, Chacko, G., additional, Epstein, R. B., additional, Holter, J., additional, Parvataneni, R., additional, Kadambi, A., additional, Park, I., additional, Elkhaled, A., additional, Essock-Burns, E., additional, Khayal, I., additional, Butowski, N., additional, Lamborn, K., additional, Chang, S., additional, Nelson, S., additional, Sanverdi, E., additional, Ozgen, B., additional, Oguz, K. K., additional, Soylemezoglu, F., additional, Mut, M., additional, Zhu, J.-J., additional, Pfannl, R., additional, Do-Dai, D., additional, Yao, K., additional, Mignano, J., additional, Wu, J. K., additional, Linendoll, N., additional, Beal, K., additional, Chan, T., additional, Yamamda, Y., additional, Holodny, A., additional, Gutin, P. H., additional, Zhang, Z., additional, Young, R. J., additional, Lupo, J. M., additional, Cha, S., additional, Chang, S. M., additional, Nelson, S. J., additional, Laperriere, N., additional, Perry, J., additional, Macdonald, D., additional, Mason, W., additional, Easaw, J., additional, Del Maestro, R., additional, Kucharczyk, W., additional, Hussey, D., additional, Greaves, K., additional, Moore, S., additional, Pouliot, J.-F., additional, Rauschkolb, P. K., additional, Smith, S. D., additional, Belden, C. J., additional, Lallana, E. C., additional, Fadul, C. E., additional, Bosscher, L., additional, Slot, M., additional, Sanchez, E., additional, Uitdehaag, B. M., additional, Vandertop, W. P., additional, Peerdeman, S. M., additional, Blumenthal, D. T., additional, Bokstein, F., additional, Artzi, M., additional, Palmon, M., additional, Aizenstein, O., additional, Sitt, R., additional, Gurevich, K., additional, Kanner, A., additional, Ram, Z., additional, Corn, B., additional, Ben Bashat, D., additional, Martinez, N., additional, Gorniak, R., additional, Tartaglino, L., additional, Scanlan, M., additional, Glass, J., additional, Kleijn, A., additional, Chen, J. W., additional, Sun, P. Z., additional, Buhrman, J., additional, Rabkin, S. D., additional, Weissleder, R., additional, Martuza, R. L., additional, Lamfers, M. L., additional, Fulci, G., additional, Brong, K. A., additional, Hekmatyar, K., additional, Jerome, N., additional, Wilson, M., additional, Kauppinen, R. A., additional, Mok, K., additional, Valenca, M. M., additional, Sherafat, E., additional, Olivier, A., additional, Pentsova, E., additional, Rosenblum, M., additional, Palomba, L., additional, Omuro, A., additional, Murad, G. J., additional, Yachnis, A. T., additional, Dunbar, E. M., additional, Li, Y., additional, Lupo, J., additional, Polley, M.-Y., additional, Kohler, N., additional, Quisling, R., additional, Swanson, K. R., additional, Gu, S., additional, Chakraborty, G., additional, Alessio, A., additional, Claridge, J., additional, Rockne, R. C., additional, Muzi, M., additional, Krohn, K. A., additional, Spence, A. M., additional, Alvord, E. C., additional, Anderson, A. R., additional, Kinahan, P., additional, Boone, A. E., additional, Mrugala, M. M., additional, Gutova, M., additional, Khankaldyyan, V., additional, Herrmann, K. A., additional, Harutyunyan, I., additional, Abramyants, Y., additional, Annala, A. J., additional, Najbauer, J., additional, Moats, R. A., additional, Shackleford, G. M., additional, Barish, M. E., additional, and Aboody, K. S., additional
- Published
- 2010
- Full Text
- View/download PDF
16. Ex vivo MR spectroscopic measure differentiates tumor from treatment effects in GBM
- Author
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Srinivasan, R., primary, Phillips, J. J., additional, VandenBerg, S. R., additional, Polley, M.-Y. C., additional, Bourne, G., additional, Au, A., additional, Pirzkall, A., additional, Cha, S., additional, Chang, S. M., additional, and Nelson, S. J., additional
- Published
- 2010
- Full Text
- View/download PDF
17. Evaluation of diffusion parameters as early biomarkers of disease progression in glioblastoma multiforme
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Khayal, I. S., primary, Polley, M.-Y. C., additional, Jalbert, L., additional, Elkhaled, A., additional, Chang, S. M., additional, Cha, S., additional, Butowski, N. A., additional, and Nelson, S. J., additional
- Published
- 2010
- Full Text
- View/download PDF
18. Enzastaurin plus temozolomide with radiation therapy in glioblastoma multiforme: A phase I study
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Butowski, N., primary, Chang, S. M., additional, Lamborn, K. R., additional, Polley, M. Y., additional, Parvataneni, R., additional, Hristova-Kazmierski, M., additional, Musib, L., additional, Nicol, S. J., additional, Thornton, D. E., additional, and Prados, M. D., additional
- Published
- 2010
- Full Text
- View/download PDF
19. Six-month progression-free survival as an alternative primary efficacy endpoint to overall survival in newly diagnosed glioblastoma patients receiving temozolomide
- Author
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Polley, M.-Y. C., primary, Lamborn, K. R., additional, Chang, S. M., additional, Butowski, N., additional, Clarke, J. L., additional, and Prados, M., additional
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- 2009
- Full Text
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20. An international Ki67 reproducibility study.
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Nielsen, T. O., Polley, M.-Y. C., Leung, S. C. Y., Mastropasqua, M. G., Zabaglo, L. A., Bartlett, J. M. S., Viale, G., McShane, L. M., Hayes, D. F., and Dowsett, M.
- Subjects
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BREAST cancer research , *CELL proliferation , *CANCER , *THERAPEUTICS , *CALIBRATION - Abstract
Introduction: In breast cancer , immunohistochemical assessment of the cell proliferation marker Ki67 is of interest for potential use in clinical management (e.g. prognosis, prediction of treatment response, monitoring the effect of neoadjuvant therapy). However, lack of consistency across labs has limited the value of Ki67. A working group was assembled to devise a strategy to harmonize Ki67 analysis and scoring and to identify procedures to improve concordance (Dowsett et al. JNCI,'11). As a result, we have conducted an international Ki67 reproducibility study. Methods: Step 1: 100 breast cancer cases arranged into 1 mm core tissue microarrays (TMAs) were centrally stained using MIB-1 antibody. Eight labs scored Ki67 as the percentage of positively stained invasive tumor cells using their own local method. Six labs repeated scoring of 50 cases on the same TMA 3 times. Ki67 data were log2-transformed to approximate a normal distribution. Pairwise intra-lab and inter-lab concordance was displayed using Bland-Altman plots. Sources of variation (e.g. patient and lab) were analyzed using two-way crossed random effects models with quantification of reproducibility via intraclass correlation coefficient (ICC; range of 0-1, 1 = highest agreement). Step 2: A web-based scoring calibration interface was created to mitigate systematic differences in Ki67 interpretation observed in Step 1. Digital images of TMA cores from 9 "training" and 9 "test" cases representing a range of Ki67 values were assembled onto the web-based interface. An initial set of observers yielding consistent scores using a standardized scoring method served as reference labs. Detailed instructions for the standardized method were provided to 8 other labs, who were asked to score the cases and learn from discrepancies observed via the web tool. Statistical criteria for passing were pre-specified. Results: In Step 1, intra-lab reproducibility was high (ICC = 0.94). Inter-lab reproducibility was only moderate (ICC = 0.71). Absolute mean Ki67 values across the series ranged from 7% to 24%. Contributing to inter-lab discordance were tumor region selection, formal counting of nuclei versus visual estimation, and subjective assessment of staining positivity. Labs using formal counting methods gave more consistent results than those using visual estimation. The calibration exercise (Step 2) helped to improve consistency: all 8 labs passed the training exercise, 4 at first attempt and 4 after 1-2 rounds of retraining. When the same 8 labs scored the 9 test calibration cases, 3 passed on first attempt. Although overall concordance improved, discrepancies for cases with low Ki67 were largely responsible for the failure of the remaining 5 labs to pass the testing. Conclusions: Absolute values and cutpoints for Ki67, and associated clinical decisions, cannot be transferred between laboratories without careful standardization of scoring methodology . Our calibration training tool offers an initial process to improve inter-lab concordance, but further studies are required to establish what concordance can be achieved in practice. A large subsequent study will assess whether a pre-specified target of success (ICC = 0.9) can be achieved on glass slides after training with the web-based calibration tools developed as part of this study [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF
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