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Your search keyword '"Pollock, Georgina L."' showing total 12 results
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12 results on '"Pollock, Georgina L."'

2. Non-SARS-CoV-2 respiratory viral detection and whole genome sequencing from COVID-19 rapid antigen test devices: a laboratory evaluation study

Author

Moso, Michael A, Taiaroa, George, Steinig, Eike, Zhanduisenov, Madiyar, Butel-Simoes, Grace, Savic, Ivana, Taouk, Mona L, Chea, Socheata, Moselen, Jean, O’Keefe, Jacinta, Prestedge, Jacqueline, Pollock, Georgina L, Khan, Mohammad, Soloczynskyj, Katherine, Fernando, Janath, Martin, Genevieve E, Caly, Leon, Barr, Ian G, Tran, Thomas, Druce, Julian, Lim, Chuan K, and Williamson, Deborah A

Published
2024
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5. Targeting of microvillus protein Eps8 by the NleH effector kinases from enteropathogenic E. coli

Author

Pollock, Georgina L., primary, Grishin, Andrey M., additional, Giogha, Cristina, additional, Gan, Jiyao, additional, Oates, Clare V., additional, McMillan, Paul J., additional, Gaeta, Isabella, additional, Tyska, Matthew J., additional, Pearson, Jaclyn S., additional, Scott, Nichollas E., additional, Cygler, Miroslaw, additional, and Hartland, Elizabeth L., additional

Published
2022
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7. The Salmonella Effector SseK3 Targets Small Rab GTPases

Author

Gan, Jiyao, primary, Scott, Nichollas E., additional, Newson, Joshua P. M., additional, Wibawa, Rachelia R., additional, Wong Fok Lung, Tania, additional, Pollock, Georgina L., additional, Ng, Garrett Z., additional, van Driel, Ian, additional, Pearson, Jaclyn S., additional, Hartland, Elizabeth L., additional, and Giogha, Cristina, additional

Published
2020
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12. Measuring Effector-Mediated Modulation of Inflammatory Responses to Infection with Enteropathogenic and Shiga Toxin-Producing E. coli.

Author

Pollock GL, Giogha C, and Hartland EL

Subjects
Animals, Cell Line, Enteropathogenic Escherichia coli pathogenicity, Escherichia coli Infections pathology, Humans, Inflammation metabolism, Inflammation microbiology, NF-KappaB Inhibitor alpha metabolism, Shiga-Toxigenic Escherichia coli pathogenicity, Enteropathogenic Escherichia coli metabolism, Escherichia coli Infections metabolism, Shiga-Toxigenic Escherichia coli metabolism, Signal Transduction, Transcription Factor RelA metabolism
Abstract

Shiga toxin-producing Escherichia coli (STEC) and the related pathogen enteropathogenic Escherichia coli (EPEC) use a type III secretion system to translocate effector proteins into host cells to modulate inflammatory signaling pathways during infection. Here we describe the procedures to investigate effector-driven modulation of host inflammatory signaling pathways in mammalian cells where bacterial effectors are ectopically expressed or in cell lines infected with STEC or EPEC. We focus on the TNF-induced NF-κB response by examining IκBα degradation by immunoblot and p65 nuclear localization in addition to using an NF-κB-dependent luciferase reporter and cytokine secretion assays. These methods can be adapted for examining effector-mediated modulation of other inflammatory stimuli and host signaling pathways.

Published
2021
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