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4. Adult Cochlear Implant Users versus Typical Hearing Persons: An Automatic Analysis of Acoustic--Prosodic Parameters

Author

Arias-Vergara, Tomás, Batliner, Anton, Rader, Tobias, Polterauer, Daniel, Högerle, Catalina, Müller, Joachim, Orozco-Arroyave, Juan-Rafael, Nöth, Elmar, and Schuster, Maria

Abstract

Purpose: The aim of this study was to investigate the speech prosody of postlingually deaf cochlear implant (CI) users compared with control speakers without hearing or speech impairment. Method: Speech recordings of 74 CI users (37 males and 37 females) and 72 age-balanced control speakers (36 males and 36 females) are considered. All participants are German native speakers and read Der Nordwind und die Sonne (The North Wind and the Sun), a standard text in pathological speech analysis and phonetic transcriptions. Automatic acoustic analysis is performed considering pitch, loudness, and duration features, including speech rate and rhythm. Results: In general, duration and rhythm features differ between CI users and control speakers. CI users read slower and have a lower voiced segment ratio compared with control speakers. A lower voiced ratio goes along with a prolongation of the voiced segments' duration in male and with a prolongation of pauses in female CI users. Rhythm features in CI users have higher variability in the duration of vowels and consonants than in control speakers. The use of bilateral CIs showed no advantages concerning speech prosody features in comparison to unilateral use of CI. Conclusions: Even after cochlear implantation and rehabilitation, the speech of postlingually deaf adults deviates from the speech of control speakers, which might be due to changed auditory feedback. We suggest considering changes in temporal aspects of speech in future rehabilitation strategies.

Published
2022
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14. PET/MRI versus PET/CT in oncology: a prospective single-center study of 330 examinations focusing on implications for patient management and cost considerations

Author

Mayerhoefer, Marius E., Prosch, Helmut, Beer, Lucian, Tamandl, Dietmar, Beyer, Thomas, Hoeller, Christoph, Berzaczy, Dominik, Raderer, Markus, Preusser, Matthias, Hochmair, Maximilian, Kiesewetter, Barbara, Scheuba, Christian, Ba-Ssalamah, Ahmed, Karanikas, Georgios, Kesselbacher, Julia, Prager, Gerald, Dieckmann, Karin, Polterauer, Stephan, Weber, Michael, Rausch, Ivo, Brauner, Bernhard, Eidherr, Harald, Wadsak, Wolfgang, and Haug, Alexander R.

Published
2020
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16. Contralateral prophylactic mastectomy in women with breast cancer without a family history or genetic predisposition: Consensus statement from the Austrian Gynecologic Oncology Working Group of the Austrian Society of Obstetrics and Gynecology

Author

Bjelic-Radisic, Vesna, Singer, Christian, Tamussino, Karl, Kölbl, Heinz, Petru, Edgar, Volgger, Birgit, Polterauer, Stephan, Oppelt, Peter, Sevelda, Paul, Bogner, Gerhard, Marth, Christian, and Austrian Gynecologic Oncology Working Group

Published
2019
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18. Empfehlungen der Arbeitsgemeinschaft Deutschsprachiger Audiologen, Neurootologen und Otologen (ADANO) zur Auswahl von Zielparametern und Prozessempfehlungen beim Einsatz von akustisch evozierten Potenzialen, otoakustischen Emissionen und der Impedanzaudiometrie in klinischen Studien: Erarbeitet von der Arbeitsgruppe ERA (AG‑ERA) der ADANO. Bestätigt vom Vorstand der ADANO am 18.01.2019

Author

Rahne, T., Dziemba, O., Lodwig, A., Polterauer, D., Thie, R., Walger, M., Wesarg, T., and Hoth, S.

Published
2019
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20. Deoxyfluorination of Ketones with Sulfur Tetrafluoride (SF4) and Dialkylamines in Continuous Flow Mode

Author

Polterauer, Dominik, Wagschal, Simon, Bersier, Michael, Bovino, Clara, Roberge, Dominique M., Hone, Christopher A., and Kappe, C. Oliver

Abstract

Fluorinated molecules are prevalent in biologically active substances, in particular, the gem-difluoro motif. However, the selective incorporation of a gem-difluoro motif into organic molecules is a laborious task. Deoxyfluorination is a promising and widely used methodology to achieve this transformation, which is usually costly or highly hazardous. Herein, we report a deoxyfluorination protocol using sulfur tetrafluoride (SF4) and diethylamine (Et2NH) to prepare gem-difluorides in continuous flow mode. The process does not require the addition of exogenous HF, and in situgenerated reagents were quenched in-line, which improved safety. The methodology was successfully applied to convert a broad range of 4-, 5-, and 6-membered ketone derivatives to their corresponding difluorinated compounds while minimizing the undesired vinyl fluoride formation. In summary, these findings improve safety and selectivity toward the synthesis of gem-difluoro compounds drastically, enabling a more efficient production of fluorinated active pharmaceutical ingredients.

Published
2024
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21. Prognostic role of transcription factor ARID1Ain patients with endometrial cancer of no specific molecular profile (NSMP) subtype

Author

Onoprienko, Arina, Hofstetter, Gerda, Muellauer, Leonhard, Dorittke, Tim, Polterauer, Stephan, Grimm, Christoph, Bartl, Thomas, and Stockman, Liz

Abstract

As more than 50% of newly diagnosed endometrial cancers remain classified as ‘no specific molecular subtype’ (NSMP) due to a lack of established biomarkers to further improve molecular subtyping, this study aims to evaluate the prognostic value of ARID1Ain endometrial cancers of NSMP subtype.

Published
2024
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31. Atezolizumab Combined With Bevacizumab and Platinum-Based Therapy for Platinum-Sensitive Ovarian Cancer: Placebo-Controlled Randomized Phase III ATALANTE/ENGOT-ov29 Trial.

Author

Kurtz, Jean-Emmanuel, Pujade-Lauraine, Eric, Oaknin, Ana, Belin, Lisa, Leitner, Katharina, Cibula, David, Denys, Hannelore, Rosengarten, Ora, Rodrigues, Manuel, de Gregorio, Nikolaus, Martinez García, Jeronimo, Petru, Edgar, Kocián, Roman, Vergote, Ignace, Pautier, Patricia, Schmalfeldt, Barbara, Gaba, Lydia, Polterauer, Stephan, Mouret Reynier, Marie-Ange, and Sehouli, Jalid

Published
2023
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33. Sulfur Tetrafluoride (SF4) as a Deoxyfluorination Reagent for Organic Synthesis in Continuous Flow Mode

Author

Polterauer, Dominik, Hanselmann, Paul, Littich, Ryan, Bersier, Michael, Roberge, Dominique M., Wagschal, Simon, Hone, Christopher A., and Kappe, C. Oliver

Abstract

We report the development of a deoxyfluorination protocol using sulfur tetrafluoride (SF4) as a reagent to prepare organofluorine compounds in continuous flow mode. The method uses mild conditions, without the use of HF, which provides an improved safety profile. The methodology was applied to successfully convert various alcohols, aldehydes, and carboxylic acids to their corresponding fluorinated compounds. Advantages of the protocol include the tolerance of protecting groups, high enantioselective control, and easy incorporation of inline reaction monitoring.

Published
2023
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36. Endovaskuläre (Transfemorales Endoluminales Aneurysma Management; TEAM) versus konventionelle offene Therapie des Abdominellen Aortenaneurysmas (AAA): Analyse einer klinischen Serie / Endovascular (Transfemoral Endoluminal Aneurysm Management, TEAM) Versus Conventional Open Repair of Abdominal Aortic Aneurysm (AAA): Analysis of a Clinical Series

Author

Kretschmer, G., Hölzenbein, Th., Teufelsbauer, H., Lammer, J., Thurnher, S., Huk, I., Polterauer, P., and Hartel, W., editor

Published
2001
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37. Prognostic factors in patients with uterine sarcoma: the SARCUT study.

Author

Zapardiel, Ignacio, Gracia Segovia, Myriam, Macuks, Ronalds, Mancari, Rosanna, Achimas-Cadariu, Patriciu, Corrado, Giacomo, Bartusevicius, Arnoldas, Sukhin, Vladyslav, Muruzabal, Juan C., Coronado Martín, Pluvio J., Gardella, Barbara, Piek, Jurgen M., Concin, Nicole, Arab, Clemente, Papatheodorou, Dimitrios, Polterauer, Stephan, Iacoponi, Sara, Nieto, Teresa, Lopez-Sanclemente, Martha C., and Trukhan, Hanna

Published
2023
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