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4 results on '"Polyacrylic acid polymer"'

1. Rheological, mechanical, and bioadhesive behavior of hydrogels to optimize skin delivery systems.

Author

Carvalho, Flávia Chiva, Calixto, Giovana, Hatakeyama, Ilka Narita, Luz, Gabriela Marielli, Gremião, Maria Palmira Daflon, and Chorilli, Marlus

Subjects
BIOADHESIVE drug delivery systems, COLLOIDS in medicine, RHEOLOGY, SKIN disease treatment, THIXOTROPY, MEDICAL polymers, PHARMACEUTICAL chemistry
Abstract

Background: Hydrogels are widely used for cutaneous formulations; thereby comparing the bioadhesive properties of polymers with a view to prolong the residence time of topical drugs on the skin would be very useful to design novel topical drug delivery systems. Aim: The objective of this study was to correlate data from rheological studies and texture profile analysis, with bioadhesion on the skin. Methods: Polyacrylic acid polymers used were carbomer homopolymer type A (C971) and type B (C974), and polycarbophil (PP) dispersed in water at various concentrations (0.1, 0.5, 1.0, 1.5, 2.0, 3.0, 5.0%, w/v). Rheological, texture, and bioadhesive properties were determined to compare the hydrogels. Results: Rheological analysis showed that all samples exhibited pseudoplastic behavior with thixotropy. Texture profile analysis showed that compressibility, hardness, and adhesiveness of the hydrogels were dependent on the polymer concentration, and the cohesion values were high. Bioadhesion of C974 and PP at 0.5 and 2% was of the same magnitude, while all samples of C971 had lower values. The bioadhesion of 5% C974 was the highest, while that 5% PP was lower, possibly because PP showed the greatest hardness and this rigidity may decrease the interaction of the polymer with the skin. Conclusion: A comprehensive comparative rheological and textural analyses of several polymers for topical systems were undertaken in terms of their bioadhesion. Therefore, it is possible to conclude that these polymers can be used for optimization of drug delivery systems on the skin. [ABSTRACT FROM AUTHOR]

Published
2013
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2. The use of polyacrylic acid polymers and auxiliary substances Span 80 and Ultrez 20 for o/w emulsion stabilization, emulsion stability analysis

Author

Puodžiūnaitė, Leonora and Drakšienė, Gailutė

Subjects
Polyacrylic acid polymer, Pemulen TR-1, Pemulen TR-2, Span 80, Carbopol Ultrez 20
Abstract

In order to prepare stable dispersive emulsion systems using low concentration of emulsifiers (0,1-0,4%) optimizing technological process, the use of new emulsifiers is investigated. Different kinds of stable emulsions can be prepared using polyacrylic acid polymers (Pemulen™ TR-1 and TR-2) while using low concentrations - 0,1-0,4% – environmentally non-toxic and human friendly universal o/w emulsion emulsifiers. Goal of this thesis - to analyse and evaluate the influence of polyacrylic acid polymer Pemulen™ TR-1 and Pemulen™ TR-2 and auxiliary substances nonionic surfactant Span 80 and Carbopol® Ultrez 20 for o/w emulsion stability and to use results of analysis in designing semi-solid formulas.

Published
2014

3. Poliakrilo rūgšties polimerų ir pagalbinių medžiagų Span 80 bei Carbopol Ultrez 20 panaudojimas emulsijų a/v stabilizavimui, emulsijų stabilumo tyrimas

Author

Puodžiūnaitė, Leonora, Drakšienė, Gailutė, Savickas, Arūnas, Savickienė, Nijolė, Janulis, Valdimaras, Ivanauskas, Liudas, Briedis, Vitalis, Ramanauskienė, Kristina, Inkėnienė, Asta Marija, Jakštas, Valdas, Radžiūnas, Raimondas, Skyrius, Vaidas, Barsteigienė, Zita, Marksienė, Rūta, Brusokas, Valdemaras, Ževžikovas, Andrejus, Vitkevičius, Konradas, Gumbrevičius, Gintautas, Ragažinskienė, Ona, Maruška, Audrius, Martinėnas, Žydrūnas, Kuncaitė, Giedrė, Zulanienė, Eglė Audronė, Jakubauskas, Mindaugas, Budrikienė, Aušra, Švarcaitė, Jūratė, Marcinkevičienė, Rasa, Balanaškienė, Rima, and Lithuanian University of Health Sciences

Subjects
Pemulen TR-1, Pemulen TR-2, Carbopol Ultrez 20, Pharmacy, Poliakrilo rūgšties polimeras, Span 80, Polyacrylic acid polymer
Abstract

Siekiant pagaminti stabilias smulkiadispersines emulsines sistemas, naudojant mažas emulsiklių koncentracijas (0,1-0,4%), optimizuojant technologinį procesą, tiriamos naujų emulsiklių panaudojimo galimybės. Poliakrilo rūgšties polimerai (Pemulen™ TR-1 ir TR-2 )-universalūs a/v emulsijų emulsikliai, nepasižymintys toksiškumu aplinkai bei žmogui, kuriuos naudojant mažomis koncentracijomis – 0,1-0,4% - gali būti pagamintos įvairių formų stabilios emulsijos. Šio darbo tikslas ištirti ir įvertinti poliakrilo rūgšties polimerų Pemulen™ TR-1 ir Pemulen™ TR-2 bei pagalbinių medžiagų, nejonogeninio emulsiklio Span 80 ir Carbopol® Ultrez 20, įtaką emulsijų a/v stabilumui, tyrimo rezultatus panaudoti, kuriant pusiau kietų preparatų receptūras. In order to prepare stable dispersive emulsion systems using low concentration of emulsifiers (0,1-0,4%) optimizing technological process, the use of new emulsifiers is investigated. Different kinds of stable emulsions can be prepared using polyacrylic acid polymers (Pemulen™ TR-1 and TR-2) while using low concentrations - 0,1-0,4% – environmentally non-toxic and human friendly universal o/w emulsion emulsifiers. Goal of this thesis - to analyse and evaluate the influence of polyacrylic acid polymer Pemulen™ TR-1 and Pemulen™ TR-2 and auxiliary substances nonionic surfactant Span 80 and Carbopol® Ultrez 20 for o/w emulsion stability and to use results of analysis in designing semi-solid formulas.

Published
2014

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