15 results on '"Pompilio, Maurício A"'
Search Results
2. A randomized, controlled, non-inferiority, multicenter trial of systemic versus intralesional treatment with meglumine antimoniate for cutaneous leishmaniasis in Brazil
- Author
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Lyra, Marcelo R, primary, Oliveira, Liliane F A, additional, Schubach, Armando O, additional, Sampaio, Raimunda N, additional, Rodrigues, Bruna C, additional, Hueb, Márcia, additional, Cota, Gláucia, additional, Silva, Rosiana E, additional, Francesconi, Fábio, additional, Pompilio, Maurício A, additional, Oliveira, Adriana F, additional, Amato, Valdir S, additional, Souza, Regina M, additional, Oliveira, Raquel V C, additional, Rosalino, Cláudia M V, additional, and Pimentel, Maria I F, additional
- Published
- 2023
- Full Text
- View/download PDF
3. A Randomized, Controlled, Noninferiority, Multicenter Trial of Systemic vs Intralesional Treatment With Meglumine Antimoniate for Cutaneous Leishmaniasis in Brazil.
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Lyra, Marcelo R, Oliveira, Liliane F A, Schubach, Armando O, Sampaio, Raimunda N R, Rodrigues, Bruna C, Hueb, Marcia, Cota, Gláucia, Silva, Rosiana E, Francesconi, Fabio, Pompilio, Maurício A, França, Adriana O, Amato, Valdir S, Souza, Regina M, Oliveira, Raquel V C, Valete, Cláudia M, and Pimentel, Maria I F
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ANTIPROTOZOAL agents ,DRUG efficacy ,RESEARCH ,WOUND healing ,LEISHMANIASIS ,CONFIDENCE intervals ,RANDOMIZED controlled trials ,COMPARATIVE studies ,RESEARCH funding ,DESCRIPTIVE statistics ,ELECTROCARDIOGRAPHY ,STATISTICAL sampling ,DRUG toxicity ,PHARMACODYNAMICS ,EVALUATION - Abstract
Background Meglumine antimoniate (MA) remains the main treatment for cutaneous leishmaniasis (CL). Uncontrolled studies suggest that intralesional MA (IL-MA) may be noninferior and safer than systemic MA (S-MA). Methods Multicenter, randomized, controlled, open-label, phase 3 clinical trial to evaluate the efficacy and toxicity of IL-MA in 3 infiltrations at 14-day intervals compared with S-MA (10–20 mg Sb
5+ /kg/day, 20 days) for CL, with noninferiority margin of 20%. Primary and secondary outcomes were definitive cure at day 180 and epithelialization rate at day 90 of treatment, respectively. A 2-year follow-up was performed to assess relapses and emergence of mucosal lesions. Adverse events (AEs) were monitored according to the Division of AIDS AE grading system. Results We evaluated 135 patients. The cure rates (95% confidence interval) for IL-MA and S-MA treatment were, respectively, 82.8% (70.5–91.4) and 67.8% (53.3–78.3) per protocol (PP) and 70.6% (58.3–81.0) and 59.7% (47.0–71.5) per intention to treat (ITT). The epithelialization rates of the IL-MA and S-MA treatment were, respectively, 79.3% (66.6–88 + 8) and 71.2% (57.9–82.2) PP and 69.1% (55.2–78.5) and 64.2% (50.0–74.2) ITT. AEs in the IL-MA and S-MA groups were, respectively, clinical, 45.6% and 80.6%; laboratory, 26.5% and 73.1%; and electrocardiogram, 8.8% and 25.4%. Ten participants in the S-MA group and 1 in the IL-MA group were discontinued due to severe or persistent AEs. Conclusions IL-MA provides a similar cure rate and results in less toxicity compared with S-MA and may be used as first-line therapy for CL patients. Clinical Trials Registration REBEC: RBR-6mk5n4. [ABSTRACT FROM AUTHOR]- Published
- 2023
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- View/download PDF
4. Obstetric, clinical, and perinatal implications of H1N1 viral infection during pregnancy
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Figueiró-Filho, Ernesto A., Oliveira, Myrna L.G., Pompilio, Maurício A., Uehara, Silvia N.O., Coelho, Lílian R., De Souza, Bruno A., and Breda, Ili
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- 2012
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5. A diagnosis of pulmonary tuberculosis and drug resistance among inmates in Mato Grosso do Sul, Brazil
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Cunha, Eunice Atsuko Totumi, primary, Marques, Marli, additional, Evangelista, Maria do Socorro Nantua, additional, Pompilio, Maurício Antonio, additional, Yassuda, Renata Terumi Shiguematsu, additional, and Souza, Albert Schiaveto de, additional
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- 2018
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6. High Prevalence of Treponema pallidum Infection in Brazilian Prisoners
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Correa, Maisa Estopa, primary, Ferreira de Sá Queiroz, Júlio Henrique, additional, Pompilio, Maurício Antonio, additional, Esther da Silva, Kesia, additional, Coimbra Motta de Castro, Ana Rita, additional, Omizolo de Souza, Ronaldo, additional, Simionatto, Simone, additional, Maria do Valle Leone de Oliveira, Sandra, additional, Ko, Albert I., additional, and Croda, Julio, additional
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- 2017
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7. A INTEGRAÇÃO DO CUIDADO: DIFICULDADES E PERSPECTIVAS.
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Mendes de Menezes, Katiucha, Pompilio, Maurício Antonio, and de Andrade, Sônia Maria Oliveira
- Abstract
Copyright of Journal of Nursing UFPE / Revista de Enfermagem UFPE is the property of Revista de Enfermagem UFPE and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2019
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8. High Prevalence of Treponema pallidum Infection in Brazilian Prisoners.
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Estopa Correa, Maisa, Croda, Julio, de Castro, Ana Rita Coimbra Motta, do Valle Leone de Oliveira, Sandra Maria, Antonio Pompilio, Maurício, de Souza, Ronaldo Omizolo, de Sá Queiroz, Júlio Henrique Ferreira, da Silva, Kesia Esther, Ko, Albert I., and Simionatto, Simone
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- 2017
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9. Estudo clínico-epidemiológico da Hepatite C em presidiários de Campo Grande, Mato Grosso do Sul
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Pompilio, Maurício Antonio and Pontes, Elenir Rose Jardim Cury
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Prisioneiros ,Hepatite C ,Genotype ,Genótipo ,Prisoners ,Antiretroviral Therapy, Highly Active ,virus diseases ,HIV ,Terapia Antirretroviral de Alta Atividade ,Hepatitis C - Abstract
A população privada de liberdade tem risco maior de adquirir doenças infecciosas e parasitárias devido a determinantes sociais como o próprio confinamento, a violência, desconhecimento de medidas de prevenção e o uso de drogas lícitas e ilícitas. Este estudo teve por objetivo conhecer os aspectos epidemiológicos e clínicos da infecção por HIV/Aids e hepatite C em prisioneiros de Campo Grande, Mato Grosso do Sul. O projeto foi desenvolvido em duas fases: a primeira entre 2008-2009 para estimar a soroprevalência da hepatite C. Foram testados 443 homens e 243 mulheres de unidades prisionais de regime fechado. As amostras anti-HCV positivas foram testadas para detecção do RNA viral (RTPCR) e genotipagem (INNO-LiPA). A prevalência geral de infecção pelo HCV foi de 4,8% (IC 95%: 3,4% a 6,8%), maior em homens, usuários de drogas injetáveis, tatuados, idade superior a 50 anos, número maior de prisões, história prévia de DST, transfusão de sangue e indivíduos com HIV /Aids. A coinfecção HIV-HCV foi de 33,3%. A segunda fase constitui-se de um grupo de 103 pacientes (72 homens e 31 mulheres) vivendo com HIV/Aids no ambiente prisional no período de 2009 a 2010. Comportamento sexual de risco, exposição a drogas lícitas e ilícitas e histórico de DST foram descritos em pacientes com infecção pelo HIV. A reincidência no sistema prisional foi frequente em ambos os sexos e doenças crônicas tiveram baixa prevalência. A prevalência da hepatite B foi de 7,4% entre os homens com HIV/Aids e 16,8% tinham VDRL reagente. Os genótipos de HCV encontrados na coinfecção foram 1 e 3. Tuberculose, pneumonia, candidíase orofaríngea e herpes zoster foram as principais doenças oportunistas. Aids foi confirmada em 55 indivíduos por critérios CDC e 65 por critério Rio de Janeiro. TARV foi utilizada por 55% dos prisioneiros com HIV/Aids. A estratégia de screening para HCV, HIV e outras doenças infecciosas em pessoas privadas de liberdade é importante porque estabelece o diagnóstico oportuno e permite o tratamento, bloquea a cadeia de transmissão e promove a melhora da qualidade de vida dos presidiários. Este benefício pode se estender para seus familiares e funcionários do sistema prisional. Prisoners in public prisons have a greater risk of acquiring infectious diseases due to social determinants such as confinement violence, lack of preventive measures, and use of licit and illicit drugs. This thesis aimed at studying the epidemiological and clinical aspects of HIV/AIDS and Hepatitis C in prisoners of the Municipality of Campo Grande, Mato Grosso do Sul State, Brazil. During the first phase of the study, 443 men and 243 women from prisons in Campo Grande were interviewed and subjected to blood collection. Anti-HCV reactive samples were analyzed by RT-PCR and genotyped. The second phase included a smaller group of 103 prisoners (72 men, 31 women) living with HIV/AIDS in prison from 2009 to 2010. The seroprevalence of HCV infection was 4.8% (3.4-6.8% - 95% confidence interval). It was observed that the seroprevalence of HCV was higher in men, injecting drug users, prisoners with tattoos, older than 50 years, prisoners with a history of multiple arrests, prisoners with a history of sexually transmitted diseases, prisoners who had previously received blood transfusions and those with HIV/AIDS. The co-infection HIV-HCV was 33.3%. Sexual behavior and exposure to licit and illicit drugs, as well as history of STD were reported by people living with HIV. The recidivism in the prison system is common in both sexes; chronic diseases have a low prevalence. Prevalence of Hepatitis B was 7.4% among men with HIV/AIDS, and 16.8% among men with syphilis. The genotypes found in the HCV co-infection were 1 and 3. Tuberculosis, pneumonia, oropharyngeal candidiasis and herpes zoster were the main opportunistic diseases. AIDS was confirmed in 55 subjects by the CDC criteria and 65 by the Rio de Janeiro criteria. Among those, 55% were on antiretroviral therapy. The screening strategy for HCV, HIV and other infectious diseases in people deprived of freedom is important because it establishes early diagnosis and allows timely treatment; it blocks the transmission chain and improves quality of life of inmates, which will benefit their families as well as employees of the prison system.
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- 2011
10. Aspectos epidemiológicos, clínicos e parasitológicos da doença de Chagas em Mato Grosso do Sul
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Pompilio, Maurício Antonio, Dorval, Maria Elizabeth Moraes Cavalheiros, Cunha, Rivaldo Venâncio da, Britto, Constança, and Borges-Pereira, José
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Chagas' disease ,Estudo transversal ,Aspectos clínicos ,Clinical aspects ,parasitic diseases ,Parasitologic aspects ,Aspectos parasitológicos ,Cross-sectional study ,Doença de Chagas - Abstract
Com o objetivo de avaliar aspectos epidemiológicos, clínicos e parasitológicos da doença de Chagas crônica, em pacientes do Hospital Universitário da Universidade Federal de Mato Grosso do Sul, realizamos um estudo seccional envolvendo 120 chagásicos e 120 controles não-chagásicos, de ambos os sexos, com idades de 16 a 82 anos. Os aspectos epidemiológicos foram avaliados por questionário, a cardiopatia por exame clínico, eletrocardiograma convencional, radiologia e ecodopplercardiograma e a presença de Trypanosoma cruzi no sangue por xenodiagnóstico e teste da reação em cadeia da polimerase. Os resultados mostraram predominância de alóctones com baixa escolaridade e referência de contato prévio com triatomíneos entre os chagásicos. Abortamento espontâneo foi mais freqüente nas mulheres chagásicas. A cardiopatia devido ao componente chagásico foi estimada em 20,2%. Apresentou-se com 7,5% de cardiomegalia, 6,2% de aneurisma de ventrículo esquerdo e com predominância de dispnéia, palpitações e hipertensão arterial. O xenodiagnóstico foi positivo em 26,1% dos chagásicos enquanto a PCR foi positiva em 53,7%. A análise dos resultados indicou que a doença de Chagas no grupo estudado apresenta características clínicas e parasitológicas que revelam peculiaridades regionais. With the objective of evaluating epidemiologic, clinical and parasitologic aspects of chronic Chagas' disease in patients from the University Hospital of the Federal University of Mato Grosso do Sul, a cross-sectional study was performed with groups of 120 chagasic and non-chagasic patients aged from 16 to 82 years. Epidemiologic aspects were evaluated by means of a questionnaire, cardiopathy by clinical examination, conventional electrocardiogram, radiology and Doppler echocardiograms (only in chagasic patients) and the presence of Trypanosoma cruzi in the blood stream by way of xenodiagnosis and polymerase chain reaction test. The results obtained indicated that the chagasic patients are predominantly alloctones with low-grade schooling, and were exposed to triatomines. The frequency of spontaneous abortion was higher in chagasic women. Chronic chagasic cardiopathy, estimated to occur in 20.2% of the patients, showed 7.5% cardiomegaly, 6.2% aneurysm of the left ventricle, and with a predominance of dyspnea, palpitations and arterial hypertension. Xenodiagnosis was positive for 26.1% of the chagasics and the PCR was positive for 53.7%, and was significantly higher in males and alloctones. An analysis of the results shows that Chagas' disease, in the group studied, presented clinical and parasitologic characteristics demonstrating significant regional differences.
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- 2005
11. Epidemiological, clinical and parasitological aspects of Chagas' disease in Mato Grosso do Sul State
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Pompilio, Maurício Antonio, Dorval, Maria Elizabeth Moraes Cavalheiros, Britto, Constança, and Pereira, José Borges
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Análise Transversal ,Trypanosomiasis ,Epidemiology ,Parasitologia ,Doenças Transmissíveis ,Chagas Disease ,Parasitology ,Period Analysis ,Tripanossomose ,Epidemiologia ,Communicable Diseases ,Doença de Chagas - Abstract
Com o objetivo de avaliar aspectos epidemiológicos, clínicos e parasitológicos da doença de Chagas crônica, em pacientes do Hospital Universitário da Universidade Federal de Mato Grosso do Sul, realizamos um estudo seccional envolvendo 120 chagásicos e 120 controles não-chagásicos, de ambos os sexos, com idades de 16 a 82 anos. Os aspectos epidemiológicos foram avaliados por questionário, a cardiopatia por exame clínico, eletrocardiograma convencional, radiologia e ecodopplercardiograma e a presença de Trypanosoma cruzi no sangue por xenodiagnóstico e teste da reação em cadeia da polimerase. Os resultados mostraram predominância de alóctones com baixa escolaridade e referência de contato prévio com triatomíneos entre os chagásicos. Abortamento espontâneo foi mais freqüente nas mulheres chagásicas. A cardiopatia devido ao componente chagásico foi estimada em 20,2%. Apresentou-se com 7,5% de cardiomegalia, 6,2% de aneurisma de ventrículo esquerdo e com predominância de dispnéia, palpitações e hipertensão arterial. O xenodiagnóstico foi positivo em 26,1% dos chagásicos enquanto a PCR foi positiva em 53,7%. A análise dos resultados indicou que a doença de Chagas no grupo estudado apresenta características clínicas e parasitológicas que revelam peculiaridades regionais. ABSTRACT - With the objective of evaluating epidemiologic, clinical and parasitologic aspects of chronic Chagas' disease in patients from the University Hospital of the Federal University of Mato Grosso do Sul, a cross-sectional study was performed with groups of 120 chagasic and non-chagasic patients aged from 16 to 82 years. Epidemiologic aspects were evaluated by means of a questionnaire, cardiopathy by clinical examination, conventional electrocardiogram, radiology and Doppler echocardiograms (only in chagasic patients) and the presence of Trypanosoma cruzi in the blood stream by way of xenodiagnosis and polymerase chain reaction test. The results obtained indicated that the chagasic patients are predominantly alloctones with low-grade schooling, and were exposed to triatomines. The frequency of spontaneous abortion was higher in chagasic women. Chronic chagasic cardiopathy, estimated to occur in 20.2% of the patients, showed 7.5% cardiomegaly, 6.2% aneurysm of the left ventricle, and with a predominance of dyspnea, palpitations and arterial hypertension. Xenodiagnosis was positive for 26.1% of the chagasics and the PCR was positive for 53.7%, and was significantly higher in males and alloctones. An analysis of the results shows that Chagas' disease, in the group studied, presented clinical and parasitologic characteristics demonstrating significant regional differences.
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- 2005
12. Hepatitis B virus infection in a population exposed to occupational hazards: firefighters of a metropolitan region in central Brazil
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Contrera-Moreno, Luciana, primary, Andrade, Sonia Maria Oliveira de, additional, Pontes, Elenir Rose Jardim Cury, additional, Stief, Alcione Cavalheiro Faro, additional, Pompilio, Maurício Antonio, additional, and Motta-Castro, Ana Rita Coimbra, additional
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- 2012
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13. Obstetric, clinical, and perinatal implications of H1N1 viral infection during pregnancy
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Figueiró-Filho, Ernesto A., primary, Oliveira, Myrna L.G., additional, Pompilio, Maurício A., additional, Uehara, Silvia N.O., additional, Coelho, Lílian R., additional, De Souza, Bruno A., additional, and Breda, Ili, additional
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- 2011
- Full Text
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14. Tuberculose em indígenas menores de 15 anos, no Estado de Mato Grosso do Sul
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Marques, Ana Maria Campos, primary, Pompilio, Maurício Antonio, additional, Santos, Sandra Christo dos, additional, Garnês, Silvio Jacks dos Anjos, additional, and Cunha, Rivaldo Venâncio da, additional
- Published
- 2010
- Full Text
- View/download PDF
15. A Estratégia de Saúde da Família e a saúde mental em Chapadão do Sul MS
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Nunes, João Donha and Pompilio, Maurício Antonio
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Suicide ,Mental Health ,Transtornos Mentais ,Mental Disorders ,Family Health Strategy ,Saúde Mental ,Suicídio ,Estratégia de Saúde da Família - Abstract
O trabalho em Saúde Mental na rede municipal de Chapadão do Sul MS, surge da necessidade de conhecer o número de casos de transtornos mentais nesta população provenientes dos números de casos de suicídio ocorridos neste município. Tem como objetivo descrever as ações de prevenção e assistência em Saúde Mental na cidade de Chapadão do Sul MS com a participação da rede de Estratégia da Saúde da Família, da referência municipal de psiquiatria e da assistência farmacêutica municipal. O estudo é descritivo, com componente de entrevistas a profissionais de saúde da atenção primária, busca de dados secundários sobre atendimentos médicos e dispensação de medicamentos na área de saúde mental, informações sobre as ações preventivas e de apoio ao uso e abuso de álcool e drogas. O número de casos de transtornos mentais em Chapadão do Sul – MS acima de14 anos no período de 2011 foi de 929 casos, em 2012 foram 725 e em 2013 foram 609. Entre os transtornos mentais a depressão e a ansiedade foram os mais encontrados. Os resultados encontrados nas séries históricas em relação ao coeficiente de mortalidade geral por suicídio em Chapadão do Sul – MS, no período de 2005 – 2013, através da classificação de Dieskstra e Gulbinat, foram valores altos em 2005, 2011 e 2013. O número de casos de depressão no período de 2011 - 2013 encontrada no município pode estar relacionado à classificação alta de suicídio. ABSTRACT - Working in Mental Health in the municipal health system of Chapadão do Sul – MS, comes from the need to know the number of cases of mental disorders in this population resulting from the numbers of suicide cases taken places at this town. This research aims to describe the prevention and assistance actions in Mental Health in Chapadão do Sul - MS, with the involvement of the Family Health Strategy system, including the municipal psychiatry and pharmaceutical references. The study is descriptive, with the component interviews with the primary health care professionals, search secondary data on medical care and dispensing medicines in mental health, information on preventive measures and support for the use and abuse of alcohol and drugs. The number of cases of mental disorders in Chapadão do Sul – MS over 14 years in the period of 2011 were 929 cases; 2012 were 725; 2013 were 609. Among mental disorders, depression and anxiety disorders are the most commonly found. The results found in the history series in general mortality rates from suicide in Chapadão do Sul – MS, from 2005 to 2013, it was checked by the Diekstra and Gulbinat classification, high values in 2005, 2011 and 2013. The number of depression cases from 2011 to 2013, found in Chapadão do Sul, it may be related to high suicide rating.
- Published
- 2015
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