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Abstract The osmotic potential in soil solutions decreases as salinity increases, and plants cannot take up enough soil water. Therefore, the osmotic potential of soil solutions can serve as an important metric of plant growth conditions in regions affected by soil salinization. Measurements of osmotic potential are labor and time consuming. This work aimed to determine more readily available soil salinity metrics to estimate the osmotic potential in soil solutions. A model to compute the osmotic potential from soil solution composition was developed and validated with data from the U.S. states of Washington, Oregon, Colorado, and Idaho. The mean relative error was 7%. Then, this model was applied to 230 datasets on soil solutions from various salinity‐affected regions of Eurasia. The correlation coefficient between logarithms of concentration of highly soluble (not including carbonates and sulfates of calcium and magnesium) in soil solutions at saturation and logarithms of osmotic potential values was above 0.99. The concentration of highly soluble salts in soil solution at saturation was chosen as the predictor of the osmotic potential. It was used to develop nomograms for evaluating the salinity‐related yield loss for major field crops, vegetables, and fruits. This work is a part of the Vadose Zone Journal tribute to the scientific legacy of Martinus van Genuchten, who championed the use of the osmotic potential for better quantification of crop salt tolerance at the macroscale and provided invaluable contributions to modeling soil salinity development and mitigation as a part of the global struggle for food security.

Introduction Gene-environment interactions (GxE) are considered to make a substantial impact on the risk of alcohol dependence (AD). Objectives The aim of the study: to test the associations between the functional polymorphism Val158Met (rs6265) in the catechol-O-methyl transferase (COMT) gene, affecting dopamine neurotransmission, and adverse childhood experiences (ACE) and their GxE interactions with AD risk. Methods The study included 149 AD inpatients (mean age 29.9 (SD=3.91), 16.1% females) and 201 healthy volunteers (23.3 (2.48), 30.1% females). The Adverse Childhood Experiences International Questionnaire (ACE-IQ) was used for assessing ACE. COMT Val158Met polymorphism was detected by RT-PCR. Results First, COMT Val158Met polymorphism was associated only with adverse childhood experience referring o parental relationship (ACE-IQ), but differently in two groups. Healthy minor Met158 carriers have lower scores on the subscale “relationship with parents/guardians” (P) (p=0.025) and “physical neglect” (PN) (p=0.059) vs. homozygous Val158 carriers. However, AD patients - Met158carriers have a tendency to a higher score on the subscale “one or no parents, parental separation or divorce” (PSD) (p=0.078). Then logistic regression revealed associations of these ACE scores with increased AD risk: P (p=0.001, OR=1.186, 95%CI [1.069-1.315]), PN (p=0.024, OR=1.254, 95%CI [1.030-1.526]), and PSD (p=0.016, OR=1.499, 95%CI [1.080-2.082]). No associations of COMT Val158Met alone or in interactions with these ACE-IQ scores with the AD risk were found. Conclusions Adverse childhood experience referring to parental relationship is associated with alcohol dependence risk and separately with COMT Val158Met, but no clear interactions in frame of GxE has been supported. Disclosure No significant relationships.

Introduction Internet addiction (IA) is reported to cause significant negative psychosocial consequences. The gender specificity of psychological characteristics that are potentially significant for the formation of IA remains understudied. Objectives To identify gender-related differences in the psychological characteristics of people with IA. Methods 100 subjects aged 16-34 years who scored 65 points or more on the Chinese Internet Addiction Scale (CIAS) were identified and divided into 2 groups by gender: group 1 (54 men) and group 2 (46 women). The individual psychological characteristics were assessed with: the Liebowitz Social Anxiety Scale (LSAS); the Bass-Perry Aggression Questionnaire (BPAQ); the Emotional Regulation Questionnaire (ERQ); the Adverse Childhood Experiences International Questionnaire (ACE-IQ); a short version of the Five-factor Personality Questionnaire (TIPI-RU) and the Cloninger Temperament and Character Inventory (TCI-125). Results Women were significantly more likely to experience fear of situations of interpersonal contact and action in public places (p=0.027). They experienced significantly more sexual violence in childhood (p=0.032) and were more likely to have personality traits such as “reward dependence” (p=0.002), “persistence” (p = 0.046), and “self-transcendence” (p=0.002). Men demonstrated physical aggression (p=0.009), suppressed emotions (p=0.019) significantly more often than women and characterized themselves as emotionally stable (p=0.048). Conclusions The gender differences identified in the cohort of individuals with IA can potentially be considered specific for this contingent, although such gender relationships can be observed in other forms of addiction and in the general population. The specificity of gender differences may reflect individual psychological markers of increased vulnerability to developing IA. Disclosure The study was financially supported by Russian Foundation for Basic Research within the framework of scientific project No 18-29-22079.

Introduction Internet addiction (IA) is a rapidly growing disorder especially among adolescents and young adults. Social anxiety is one of the risk factors for IA. Also, genes involved in dopaminergic and serotoninergic systems are among the candidate genes most frequently associated with IA. Objectives The study aimed to investigate the association between social anxiety level and genetic markers in young adult Internet addicts. Methods IA group included 44 people (Chen/Chinese Internet Addiction Scale (CIAS) score ≥ 65), 75,0% males), the average age 22,0 [18,0;25,0] y.o. (Md [Q1; Q3]). Healthy control group (CIAS score was less 65) included 120 people, (73,3% males), the average age 23,0 [22,0;24,0] y.o. Psychometric measures: Liebowitz Social Anxiety Scale (LSAS). Genetic markers: rs2072450 in GRIN2A, rs2832407 in GRiK-GluR5, HUMTH01 in TH01(S=9 repeats). The impact of genotypes on social anxiety scores was identified using Proportional Odd Logit modeling taking into account group affiliation. Results Group of IA reported significantly higher levels in almost all LSAS measures including total score. We found that carriers of the genotypes rs2072450 CC (p=0.004 vs.CA/AA), rs2832407 CC (p=0.023 vs AA), and TH01 SS (p=0.013 vs. LL) scored significantly higher of LSAS total in the IA group. There were no significant differences in the healthy controls group. Conclusions The rs2072450(CC) in GRIN2A, rs2832407(CC) in GRiK-GluR5, and HUMTH01 in TH01(SS) genotypes may be possibly associated with higher social anxiety levels in Internet addicts. Disclosure The study was supported by the Russian Foundation for Basic Research (RFBR), project #18-29-22079.

Introduction Internet-addiction (IA) is one of the most common non-chemical (or behavioral) addictions with genetic impact and substantial effects of psychological and personality characteristics, taking into account the childhood traumatic experience. Gene-environment interactions (GxE) may substantially impact on the risk of Internet-addiction (IA). Objectives Aim: to test the associations between the functional polymorphism rs6265 (Val66Met) in brain-derived neurotrophic factor (BDNF) gene, affecting BDNF function, and childhood traumatic experience and their GxE interactions with IA risk. Methods In total 456 participants were screened with Chinese Internet Addiction Scale (CIAS) to cut a cohort on two groups: IA (CIAS total score ≥ 65, n=100) and controls (CIAS total score less 64, n=356). The Adverse Childhood Experiences International Questionnaire (ACE-IQ) was used to assess childhood traumatic experience using its main domains: parents (P), family (F), abuse (A) and violence (V). BDNF Val158Met polymorphism was detected by RT-PCR. Results Logistic regression revealed associations of P scores with increased IA risk only after adjustment for sex and age (p=0.01, OR=1.166, 95%CI[1.038-1.309]) and V scores with decreased IA risk (p=0.000, OR=0.799, 95%CI [0,233;0,744] only before adjustment. No associations of F and A with IA risk were found. BDNF Val158Met per se was not associated with IA risk, but significant effect of interaction V score*BDNF rs6265 CC on IA risk in “protective” manner was revealed (р=0.039, OR=0.873, 95%CI[0.768-0.993]) in a model adjusted for sex and age. Conclusions Childhood violence experience interacts with BDNF Val158Met polymorphism and CC (ValVal) genotype may be possibly protective factor decreasing the internet addiction risk Disclosure This work was carried out with the financial support of the Russian Foundation for Basic Research: RFBR grant # 18-29-22079

The osmotic potential in soil solutions decreases as salinity increases, and plants cannot take up enough soil water. Therefore, the osmotic potential of soil solutions can serve as an important metric of plant growth conditions in regions affected by soil salinization. Measurements of osmotic potential are labor and time consuming. This work aimed to determine more readily available soil salinity metrics to estimate the osmotic potential in soil solutions. A model to compute the osmotic potential from soil solution composition was developed and validated with data from the U.S. states of Washington, Oregon, Colorado, and Idaho. The mean relative error was 7%. Then, this model was applied to 230 datasets on soil solutions from various salinity‐affected regions of Eurasia. The correlation coefficient between logarithms of concentration of highly soluble (not including carbonates and sulfates of calcium and magnesium) in soil solutions at saturation and logarithms of osmotic potential values was above 0.99. The concentration of highly soluble salts in soil solution at saturation was chosen as the predictor of the osmotic potential. It was used to develop nomograms for evaluating the salinity‐related yield loss for major field crops, vegetables, and fruits. This work is a part of the Vadose Zone Journal tribute to the scientific legacy of Martinus van Genuchten, who championed the use of the osmotic potential for better quantification of crop salt tolerance at the macroscale and provided invaluable contributions to modeling soil salinity development and mitigation as a part of the global struggle for food security. Core Ideas: Root zone salinity characterization can benefit from osmotic potential estimates from soil solution composition.The proposed model relates osmotic potential to concentrations of major ions in soil solution.Osmotic potential estimates correlate well with major salinity metrics.Regressions of osmotic pressure on salinity metrics are affected by the salinity type. [ABSTRACT FROM AUTHOR]

This article explores children's perspectives on risk and protection in the context of war, exclusion, political conflict and immigration via the example of the excluded Ethiopian immigrant community in Israel. Thirty children of Ethiopian origin, aged four to six, shared their views on risk and protection with the aid of photography, drawings and group discussions. The qualitative, thematic and linguistic analyses of the children's verbal explanations showed that most children related protective factors to their macro-level, in spite of the war. In their neighborhoods (exosystem) most children described factors referring to risk, while in their home and kindergarten (microsystems), children described a mix of risk and protective factors. Most children used the third-person when referring to risk and the first person when talking about protection. The results support a call for a context-informed child-centered approach. Understanding children's experiences is crucial in creating prevention and intervention programs for marginalized groups.

The goal of every qualitative interview is to produce rich data. Inducing storytelling is a challenge in every interview. Interviews with young children (ages 3–6) present an additional challenge because of perceived power differences between children and adults. This research examines how interviewers’ questions and expressions encourage or inhibit children from telling their stories. We extracted 1,339 child interviewee–adult interviewer turn exchanges from a national study on children’s perspectives on risk and protection ( N = 420) and analyzed them in two steps. First, we categorized the interviewers’ questions and expressions and children’s responses. Seven categories were found for interviewer expressions and five for children’s responses. We then examined the relationship between interviewer categories and children’s responses. The categories that produced the richest data were encouragement, open-ended questions, and question request. Sequence of utterances and closed-ended questions produced the least storytelling. We did not find significant differences based on a child’s gender with regard to the interviewer categories. The results and implications for researching young children are addressed.

Previous studies in animal models of cocaine craving have delineated broad changes in DNA methylation profiles in the nucleus accumbens. A crucial factor for progress in behavioral and mental health epigenetics is the discovery of epigenetic markers in peripheral tissues. Several studies in primates and humans have associated differences in behavioral phenotypes with changes in DNA methylation in T cells and brain. Herein, we present a pilot study (n = 27) showing that the T cell DNA methylation profile differentiates persons with a substance use disorder from controls. Intervention with dehydroepiandrosterone (DHEA), previously shown to have a long-term therapeutic effect on human addicts herein resulted in reversal of DNA methylation changes in genes related to pathways associated with the addictive state.

Background: The development of epidemiological instruments has enabled the assessment of mental disorders in youth in countries that plan policy according to evidence-based principles. The Israel Survey of Mental Health among Adolescents (ISMEHA) was conducted in 2004-2005 in a representative sample of 957 adolescents aged 14-17 and their mothers. Methods: The aims of this study were to estimate prevalence rates of internalizing and externalizing mental disorders and their socio-demographic and health correlates. Disorders were ascertained with the Development and Well-Being Assessment inventory and verified by child psychiatrists. Results: The prevalence rates were 11.7%, 8.1% and 4.8% for any disorder, internalizing disorders and externalizing disorders, respectively. Distinct risk factors were associated with the different types of disorders: internalizing disorders were associated with female gender, chronic medical conditions and being cared for by a welfare agency. Risk factors for externalizing disorders were male gender, having divorced or single parents, being an only child or having only one sibling. Learning disability was associated with both types of disorders. Conclusions: The risk and protective factors related to internalizing and externalizing disorders are interpreted within the framework of family composition in this multicultural society.