Search

Your search keyword '"Pontari, Antonella"' showing total 22 results
Start Over Author "Pontari, Antonella"
22 results on '"Pontari, Antonella"'

2. Basal CD34+ Cell Count Predicts Peripheral Blood Stem Cell Mobilization in Healthy Donors after Administration of Granulocyte Colony–Stimulating Factor: A Longitudinal, Prospective, Observational, Single-Center, Cohort Study

Author

Martino, Massimo, Gori, Mercedes, Pitino, Annalisa, Gentile, Massimo, Dattola, Antonia, Pontari, Antonella, Vigna, Ernesto, Moscato, Tiziana, Recchia, Anna Grazia, Barilla', Santina, Tripepi, Giovanni, and Morabito, Fortunato

Published
2017
Full Text
View/download PDF

3. Tolerability and Efficacy of Busulfan and Fludarabine As Allogeneic Pretransplant Conditioning Therapy in Acute Myeloid Leukemia: Comparison With Busulfan and Cyclophosphamide Regimen

Author

Fedele, Roberta, Messina, Giuseppe, Martinello, Tiziana, Gallo, Giuseppe Alberto, Pontari, Antonella, Moscato, Tiziana, Console, Giuseppe, Dattola, Antonia, Princi, Domenica, Cuzzola, Maria, Alati, Caterina, Ronco, Francesca, Molica, Stefano, Irrera, Giuseppe, and Martino, Massimo

Published
2014
Full Text
View/download PDF

5. Identifying and Managing CAR T-Cell–Mediated Toxicities: on behalf of an Italian CAR-T Multidisciplinary Team

Author

Martino, Massimo, primary, Macheda, Sebastiano, additional, Aguglia, Umberto, additional, Arcudi, Luciano, additional, Pucci, Giulia, additional, Martino, Bruno, additional, Altomonte, Maria, additional, Rossetti, Antonio Maria, additional, Cusumano, Giuseppa, additional, Russo, Letteria, additional, Imbalzano, Lucrezia, additional, Stelitano, Caterina, additional, Alati, Caterina, additional, Germano’, Jessyca, additional, Labate, Demetrio, additional, Amalfi, Vincenzo, additional, Florenzano, Maria Teresa, additional, Morabito, Antonella, additional, Borzumati, Vittoria, additional, Dattola, Vincenzo, additional, Gattuso, Caterina, additional, Moschella, Antonio, additional, Quattrone, Domenico, additional, Curmaci, Francesco, additional, Franzutti, Claudio, additional, Scappatura, Giuseppe, additional, Rao, Carmelo Massimiliano, additional, Loddo, Viviana, additional, Pontari, Antonella, additional, Pellicano’, Maria, additional, Surace, Rosangela, additional, Sanguedolce, Cristina, additional, Naso, Virginia, additional, Ferreri, Anna, additional, Irrera, Giuseppe, additional, Console, Giuseppe, additional, Moscato, Tiziana, additional, Loteta, Barbara, additional, Canale, Filippo Antonio, additional, Trimarchi, Alfonso, additional, Monteleone, Renza, additional, Said, Al Sayyad, additional, Cirrone, Frank, additional, and Bruno, Benedetto, additional

Published
2021
Full Text
View/download PDF

10. Identifying and managing CAR T-cell–mediated toxicities: on behalf of an Italian CAR-T multidisciplinary team

Author

Martino, Massimo, Macheda, Sebastiano, Aguglia, Umberto, Arcudi, Luciano, Pucci, Giulia, Martino, Bruno, Altomonte, Maria, Rossetti, Antonio Maria, Cusumano, Giuseppa, Russo, Letteria, Imbalzano, Lucrezia, Stelitano, Caterina, Alati, Caterina, Germano’, Jessyca, Labate, Demetrio, Amalfi, Vincenzo, Florenzano, Maria Teresa, Morabito, Antonella, Borzumati, Vittoria, Dattola, Vincenzo, Gattuso, Caterina, Moschella, Antonio, Quattrone, Domenico, Curmaci, Francesco, Franzutti, Claudio, Scappatura, Giuseppe, Rao, Carmelo Massimiliano, Loddo, Viviana, Pontari, Antonella, Pellicano’, Maria, Surace, Rosangela, Sanguedolce, Cristina, Naso, Virginia, Ferreri, Anna, Irrera, Giuseppe, Console, Giuseppe, Moscato, Tiziana, Loteta, Barbara, Canale, Filippo Antonio, Trimarchi, Alfonso, Monteleone, Renza, Al Sayyad, Said, Cirrone, Frank, and Bruno, Benedetto

Abstract

ABSTRACTIntroductionChimeric antigen receptor (CAR)-T-cell therapy is a new treatment for patients with hematologic malignancies in which other therapies have failed.Areas coveredThe review provides an overview for recognizing and managing the most acute toxicities related to CAR-T cells.Expert opinionThe development of immune-mediated toxicities is a common challenge of CAR-T therapy. The mechanism that determines this toxicity is still unclear, although an unfavorable tumor microenvironment and a pro-inflammatory state put patients at risk. The monitoring, diagnosis, and treatment of post-CAR-T toxicities must be determined and based on international guidelines and internal clinical practice. It is urgent to identify biomarkers that can identify patients at greater risk of developing complications. The adoption of consistent grading criteria is necessary to improve toxicity management strategies continually. The first-line therapy consists of supportive care and treatment with tocilizumab or corticosteroids. An early start of cytokine blockade therapies could mitigate toxicity. The plan will include cytokine release prophylaxis, a risk-adapted treatment, prevention of on-target/off-tumor effect, and a switch on/off CAR-T approach.

Published
2022
Full Text
View/download PDF

11. Basal CD34 + Cell Count Predicts Peripheral Blood Stem Cell Mobilization in Healthy Donors after Administration of Granulocyte Colony–Stimulating Factor: A Longitudinal, Prospective, Observational, Single-Center, Cohort Study

Author

Martino, Massimo, primary, Gori, Mercedes, additional, Pitino, Annalisa, additional, Gentile, Massimo, additional, Dattola, Antonia, additional, Pontari, Antonella, additional, Vigna, Ernesto, additional, Moscato, Tiziana, additional, Recchia, Anna Grazia, additional, Barilla', Santina, additional, Tripepi, Giovanni, additional, and Morabito, Fortunato, additional

Published
2017
Full Text
View/download PDF

12. Basal CD34+ Cell Count Predicts Peripheral Blood Hematopoietic Progenitor Cells Mobilization in Healthy Donors after Administration of G-CSF

Author

Martino, Massimo, primary, Gori, Mercedes, additional, Pitino, Annalisa, additional, Dattola, Antonella, additional, Fedele, Roberta, additional, Gallo, Giuseppe Alberto, additional, Barillà, Santina, additional, Pontari, Antonella, additional, Irrera, Giuseppe, additional, Messina, Giuseppe, additional, Moscato, Tiziana, additional, Console, Giuseppe, additional, Morabito, Fortunato, additional, and Tripepi, Giovanni, additional

Published
2016
Full Text
View/download PDF

15. Polycythemia following allogeneic hematopoietic progenitor cell transplantation occurring during iron chelation therapy.

Author

Fedele, Roberta, Cuzzola, Maria, Irrera, Giuseppe, Pontari, Antonella, D'Ascola, Domenico Giuseppe, Oliva, Esther Natalie, and Martino, Massimo

Subjects
ACUTE myeloid leukemia, POLYCYTHEMIA, DRUG resistance in cancer cells, TRANSPLANTATION of organs, tissues, etc., CHELATION therapy
Abstract

The article presents a case study of a 52-years-old male patient diagnosed with acute myeloid leukemia with normal karyotype. Topics discussed include development of resistance to drugs such as citarabine and etoposide, development of polycythemiaduring iron chelating therapy (ICT) in the patient after allogeneic hematopoietic progenitor cell transplantation (allo-HPCT), and association of polycythemia with erytheroid.

Published
2016
Full Text
View/download PDF

19. Predictive factors that affect the mobilization of CD34+cells in healthy donors treated with recombinant granulocyte colony-stimulating factor (G-CSF)

Author

Martino, Massimo, primary, Callea, Ida, additional, Condemi, Antonia, additional, Dattola, Antonella, additional, Irrera, Giuseppe, additional, Marcuccio, Daniela, additional, Messina, Giuseppe, additional, Pontari, Antonella, additional, Pucci, Giulia, additional, Console, Giuseppe, additional, and lacopino, Pasquale, additional

Published
2006
Full Text
View/download PDF

20. High-Dose Chemotherapy with Mitoxantrone + Melphalan and Autologous Stem Cell Rescue in Metastatic Breast Cancer Patients: A Study of Feasibility and Tolerability

Author

Martino, Massimo, primary, Morabito, Fortunato, additional, Console, Giuseppe, additional, Irrera, Giuseppe, additional, Pucci, Giulia, additional, Penna, Giuseppa, additional, Dattola, Antonella, additional, Callea, Ida, additional, Pontari, Antonella, additional, Condemi, Antonia, additional, Messina, Giuseppe, additional, Nardi, Mario, additional, Cicero, Giovanni, additional, Molica, Stefano, additional, Palazzo, Salvatore, additional, and Iacopino, Pasquale, additional

Published
2003
Full Text
View/download PDF

21. Fractal Analysis and Biophysical Investigation of Muscular Tissue Damaged due to Low Temperature: A Pilot Study

Author

Bianciardi, Giorgio, Buonsanti, Michele, Pontari, Antonella, and Tripodi, Sergio

Abstract

Severe damage is produced in tissues by freezing and thawing. Until now, a great majority of the studies are performed qualitatively, lacking any quantitative approach. An important step is to choose the best option among different freezing methods. To approach the complex problem of damage produced in tissues by freezing, in this paper we present the classical mechanics approach and a quantitative study making use of a fractal methodology (evaluation of fractal dimension by box-counting method). A comparative fractal analysis between two different steps of freezing the human thoracic diaphragm muscle has been performed to quantify the voids and cracks produced by freezing (samples were placed in a cryostat chamber). Moreover, a standard Euclidean morphometry was performed to determine area and shape of the muscle nuclei after the two steps of freezing. Fractal dimension of the ice-tissue interface structures increased with decreasing temperature (p<0.0001), percentage of cell muscle decreased (p<0.01), while standard morphometry of the nuclei didnt show any modifications. Our results show the ability of the fractal approach to accurately quantify the damage produced by freezing and reveals that the lowest temperature produces the most damage.

Published
2008
Full Text
View/download PDF

22. A Theoretical Model to Fracture in Cell Membrane

Author

Buonsanti, Michele and Pontari, Antonella

Abstract

A new stress function modelling the fails in biological tissue is here proposed. Under the assumption that the cell membrane may be modelled as neo-Hookean materials, we develop the problem in the framework of non-linear elasticity. We attempt to model the ice nucleation phenomenon when freezing and thawing occurs in cellular cryo-preservation. The ice seed generated surface can be either soft or wrinkled and, when the latter emerges a punch contact against the cell membrane takes place. Restricting our attention on opportune mono-dimensional sub-set, we extend the multiple critical points theorem at our model. We find a particular solution in agreement to the classical fracture models besides a response function in accordance to the stress and strain field distribution in biological materials.

Published
2008
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results