1. Freeze-casting for PLGA/carbonated apatite composite scaffolds: structure and properties
- Author
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Benjamin Duployer, Roberto Hübler, Christophe Tenailleau, Dominique Poquillon, Christèle Combes, Mariane Schardosim, Sophie Cazalbou, Jérémy Soulié, Christian Rey, Centre National de la Recherche Scientifique - CNRS (FRANCE), Institut National Polytechnique de Toulouse - INPT (FRANCE), Université Toulouse III - Paul Sabatier - UT3 (FRANCE), Pontificia Universidade Catolica do Rio Grande do Sul - PUCRS (BRAZIL), Centre interuniversitaire de recherche et d'ingenierie des matériaux (CIRIMAT), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC), Pontifícia Universidade Católica do Rio Grande do Sul [Porto Alegre] (PUCRS), and Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
- Subjects
Scaffold ,Materials science ,Matériaux ,Composite number ,Bioengineering ,Composite ,02 engineering and technology ,Porous scaffolds ,010402 general chemistry ,01 natural sciences ,Apatite ,[SPI.MAT]Engineering Sciences [physics]/Materials ,Biomaterials ,chemistry.chemical_compound ,Polylactic Acid-Polyglycolic Acid Copolymer ,Apatites ,[SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering ,Lactic Acid ,Composite material ,Porosity ,Génie des procédés ,chemistry.chemical_classification ,Bone engineering ,Tissue Engineering ,Tissue Scaffolds ,Carbonated apatite ,PLGA ,Porosimetry ,Polymer ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,chemistry ,Mechanics of Materials ,visual_art ,visual_art.visual_art_medium ,Dimethyl carbonate ,0210 nano-technology ,Polyglycolic Acid - Abstract
International audience; This paper focuses on the fabrication of three-dimensional porous PLGA-biomimetic carbonated apatite composite scaffolds by freeze-casting and using dimethyl carbonate as a solvent. Several charge/polymer ratios were tested in order to finely understand the influence of the filler rate on the scaffold porosity and mechanical and degradation properties using complementary characterization techniques (SEM, mercury porosimetry and X-ray microtomography). It was demonstrated that the apatite ratio within the composite scaffold has a strong influence in terms of architecture, material cohesion, mechanical properties and in vitro degradation properties. An optimum biomimetic apatite ratio was reached to combine good mechanical properties (higher rigidity) and material cohesion. In vitro degradation studies showed that higher apatite filler rates limited PLGA degradation and enhanced the hydrophilicity of the scaffolds which is expected to improve the biological properties of the scaffolds in addition to the bioactivity related to the presence of the apatite analogous to bone mineral.
- Published
- 2017
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