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294 results on '"Pooler, Loreall"'

1. Shared graft-versus-leukemia minor histocompatibility antigens in DISCOVeRY-BMT

Author

Olsen, Kelly S., Jadi, Othmane, Dexheimer, Sarah, Bortone, Dante S., Vensko, Steven P., II, Bennett, Sarah, Tang, Hancong, Diiorio, Marisa, Saran, Tanvi, Dingfelder, David, Zhu, Qianqian, Wang, Yiwen, Haiman, Christopher A., Pooler, Loreall, Sheng, Xin, Webb, Amy, Pasquini, Marcelo C., McCarthy, Philip L., Spellman, Stephen R., Weimer, Eric, Hahn, Theresa, Sucheston-Campbell, Lara, Armistead, Paul M., and Vincent, Benjamin G.

Published
2023
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2. Genetic analyses of diverse populations improves discovery for complex traits.

Author

Wojcik, Genevieve L, Graff, Mariaelisa, Nishimura, Katherine K, Tao, Ran, Haessler, Jeffrey, Gignoux, Christopher R, Highland, Heather M, Patel, Yesha M, Sorokin, Elena P, Avery, Christy L, Belbin, Gillian M, Bien, Stephanie A, Cheng, Iona, Cullina, Sinead, Hodonsky, Chani J, Hu, Yao, Huckins, Laura M, Jeff, Janina, Justice, Anne E, Kocarnik, Jonathan M, Lim, Unhee, Lin, Bridget M, Lu, Yingchang, Nelson, Sarah C, Park, Sung-Shim L, Poisner, Hannah, Preuss, Michael H, Richard, Melissa A, Schurmann, Claudia, Setiawan, Veronica W, Sockell, Alexandra, Vahi, Karan, Verbanck, Marie, Vishnu, Abhishek, Walker, Ryan W, Young, Kristin L, Zubair, Niha, Acuña-Alonso, Victor, Ambite, Jose Luis, Barnes, Kathleen C, Boerwinkle, Eric, Bottinger, Erwin P, Bustamante, Carlos D, Caberto, Christian, Canizales-Quinteros, Samuel, Conomos, Matthew P, Deelman, Ewa, Do, Ron, Doheny, Kimberly, Fernández-Rhodes, Lindsay, Fornage, Myriam, Hailu, Benyam, Heiss, Gerardo, Henn, Brenna M, Hindorff, Lucia A, Jackson, Rebecca D, Laurie, Cecelia A, Laurie, Cathy C, Li, Yuqing, Lin, Dan-Yu, Moreno-Estrada, Andres, Nadkarni, Girish, Norman, Paul J, Pooler, Loreall C, Reiner, Alexander P, Romm, Jane, Sabatti, Chiara, Sandoval, Karla, Sheng, Xin, Stahl, Eli A, Stram, Daniel O, Thornton, Timothy A, Wassel, Christina L, Wilkens, Lynne R, Winkler, Cheryl A, Yoneyama, Sachi, Buyske, Steven, Haiman, Christopher A, Kooperberg, Charles, Le Marchand, Loic, Loos, Ruth JF, Matise, Tara C, North, Kari E, Peters, Ulrike, Kenny, Eimear E, and Carlson, Christopher S

Subjects
Humans, Body Height, Cohort Studies, Genetics, Medical, Multifactorial Inheritance, Minority Groups, African Continental Ancestry Group, Asian Continental Ancestry Group, Hispanic Americans, Women's Health, United States, Female, Male, Health Status Disparities, Genome-Wide Association Study, Health Equity, Genetics, Medical, General Science & Technology
Abstract

Genome-wide association studies (GWAS) have laid the foundation for investigations into the biology of complex traits, drug development and clinical guidelines. However, the majority of discovery efforts are based on data from populations of European ancestry1-3. In light of the differential genetic architecture that is known to exist between populations, bias in representation can exacerbate existing disease and healthcare disparities. Critical variants may be missed if they have a low frequency or are completely absent in European populations, especially as the field shifts its attention towards rare variants, which are more likely to be population-specific4-10. Additionally, effect sizes and their derived risk prediction scores derived in one population may not accurately extrapolate to other populations11,12. Here we demonstrate the value of diverse, multi-ethnic participants in large-scale genomic studies. The Population Architecture using Genomics and Epidemiology (PAGE) study conducted a GWAS of 26 clinical and behavioural phenotypes in 49,839 non-European individuals. Using strategies tailored for analysis of multi-ethnic and admixed populations, we describe a framework for analysing diverse populations, identify 27 novel loci and 38 secondary signals at known loci, as well as replicate 1,444 GWAS catalogue associations across these traits. Our data show evidence of effect-size heterogeneity across ancestries for published GWAS associations, substantial benefits for fine-mapping using diverse cohorts and insights into clinical implications. In the United States-where minority populations have a disproportionately higher burden of chronic conditions13-the lack of representation of diverse populations in genetic research will result in inequitable access to precision medicine for those with the highest burden of disease. We strongly advocate for continued, large genome-wide efforts in diverse populations to maximize genetic discovery and reduce health disparities.

Published
2019

3. Novel genetic variants associated with mortality after unrelated donor allogeneic hematopoietic cell transplantation

Author

Hahn, Theresa, Wang, Junke, Preus, Leah M., Karaesmen, Ezgi, Rizvi, Abbas, Clay-Gilmour, Alyssa I., Zhu, Qianqian, Wang, Yiwen, Yan, Li, Liu, Song, Stram, Daniel O., Pooler, Loreall, Sheng, Xin, Haiman, Christopher A., Berg, David Van Den, Webb, Amy, Brock, Guy, Spellman, Stephen R., Onel, Kenan, McCarthy, Philip L., Pasquini, Marcelo C., and Sucheston-Campbell, Lara E.

Published
2021
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4. Two Novel Susceptibility Loci for Prostate Cancer in Men of African Ancestry

Author

Conti, David V, Wang, Kan, Sheng, Xin, Bensen, Jeannette T, Hazelett, Dennis J, Cook, Michael B, Ingles, Sue A, Kittles, Rick A, Strom, Sara S, Rybicki, Benjamin A, Nemesure, Barbara, Isaacs, William B, Stanford, Janet L, Zheng, Wei, Sanderson, Maureen, John, Esther M, Park, Jong Y, Xu, Jianfeng, Stevens, Victoria L, Berndt, Sonja I, Huff, Chad D, Wang, Zhaoming, Yeboah, Edward D, Tettey, Yao, Biritwum, Richard B, Adjei, Andrew A, Tay, Evelyn, Truelove, Ann, Niwa, Shelley, Sellers, Thomas A, Yamoah, Kosj, Murphy, Adam B, Crawford, Dana C, Gapstur, Susan M, Bush, William S, Aldrich, Melinda C, Cussenot, Olivier, Petrovics, Gyorgy, Cullen, Jennifer, Neslund-Dudas, Christine, Stern, Mariana C, Jarai, Zsofia-Kote, Govindasami, Koveela, Chokkalingam, Anand P, Hsing, Ann W, Goodman, Phyllis J, Hoffmann, Thomas, Drake, Bettina F, Hu, Jennifer J, Clark, Peter E, Van Den Eeden, Stephen K, Blanchet, Pascal, Fowke, Jay H, Casey, Graham, Hennis, Anselm JM, Han, Ying, Lubwama, Alexander, Thompson, Ian M, Leach, Robin, Easton, Douglas F, Schumacher, Fredrick, Van den Berg, David J, Gundell, Susan M, Stram, Alex, Wan, Peggy, Xia, Lucy, Pooler, Loreall C, Mohler, James L, Fontham, Elizabeth TH, Smith, Gary J, Taylor, Jack A, Srivastava, Shiv, Eeles, Rosalind A, Carpten, John, Kibel, Adam S, Multigner, Luc, Parent, Marie-Elise, Menegaux, Florence, Cancel-Tassin, Geraldine, Klein, Eric A, Brureau, Laurent, Stram, Daniel O, Watya, Stephen, Chanock, Stephen J, Witte, John S, Blot, William J, Henderson, Brian E, and Haiman, Christopher A

Subjects
Aging, Human Genome, Cancer, Prevention, Prostate Cancer, Biotechnology, Clinical Research, Genetics, Urologic Diseases, 2.1 Biological and endogenous factors, Aetiology, Blacks, Case-Control Studies, Checkpoint Kinase 2, Chromosomes, Human, Pair 13, Chromosomes, Human, Pair 22, Gene Frequency, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Insulin Receptor Substrate Proteins, Male, Polymorphism, Single Nucleotide, Prostatic Neoplasms, PRACTICAL/ELLIPSE Consortium, Black People, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

Prostate cancer incidence is 1.6-fold higher in African Americans than in other populations. The risk factors that drive this disparity are unknown and potentially consist of social, environmental, and genetic influences. To investigate the genetic basis of prostate cancer in men of African ancestry, we performed a genome-wide association meta-analysis using two-sided statistical tests in 10 202 case subjects and 10 810 control subjects. We identified novel signals on chromosomes 13q34 and 22q12, with the risk-associated alleles found only in men of African ancestry (13q34: rs75823044, risk allele frequency = 2.2%, odds ratio [OR] = 1.55, 95% confidence interval [CI] = 1.37 to 1.76, P = 6.10 × 10-12; 22q12.1: rs78554043, risk allele frequency = 1.5%, OR = 1.62, 95% CI = 1.39 to 1.89, P = 7.50 × 10-10). At 13q34, the signal is located 5' of the gene IRS2 and 3' of a long noncoding RNA, while at 22q12 the candidate functional allele is a missense variant in the CHEK2 gene. These findings provide further support for the role of ancestry-specific germline variation in contributing to population differences in prostate cancer risk.

Published
2017

5. Pre-HCT mosaicism increases relapse risk and lowers survival in acute lymphoblastic leukemia patients post–unrelated HCT

Author

Wang, Yiwen, Zhou, Weiyin, Wang, Junke, Karaesmen, Ezgi, Tang, Hancong, McCarthy, Philip L., Pasquini, Marcelo C., Wang, Youjin, McReynolds, Lisa J., Katki, Hormuzd A., Machiela, Mitchell J., Yeager, Meredith, Pooler, Loreall, Sheng, Xin, Haiman, Christopher A., Van Den Berg, David, Spellman, Stephen R., Wang, Tao, Kuxhausen, Michelle, Chanock, Stephen J., Lee, Stephanie J., Clay-Gilmour, Alyssa I., Hahn, Theresa E., Gadalla, Shahinaz M., and Sucheston-Campbell, Lara E.

Published
2021
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6. Prostate Cancer Susceptibility in Men of African Ancestry at 8q24

Author

Han, Ying, Rand, Kristin A, Hazelett, Dennis J, Ingles, Sue A, Kittles, Rick A, Strom, Sara S, Rybicki, Benjamin A, Nemesure, Barbara, Isaacs, William B, Stanford, Janet L, Zheng, Wei, Schumacher, Fredrick R, Berndt, Sonja I, Wang, Zhaoming, Xu, Jianfeng, Rohland, Nadin, Reich, David, Tandon, Arti, Pasaniuc, Bogdan, Allen, Alex, Quinque, Dominique, Mallick, Swapan, Notani, Dimple, Rosenfeld, Michael G, Jayani, Ranveer Singh, Kolb, Suzanne, Gapstur, Susan M, Stevens, Victoria L, Pettaway, Curtis A, Yeboah, Edward D, Tettey, Yao, Biritwum, Richard B, Adjei, Andrew A, Tay, Evelyn, Truelove, Ann, Niwa, Shelley, Chokkalingam, Anand P, John, Esther M, Murphy, Adam B, Signorello, Lisa B, Carpten, John, Leske, M Cristina, Wu, Suh-Yuh, Hennis, Anslem JM, Neslund-Dudas, Christine, Hsing, Ann W, Chu, Lisa, Goodman, Phyllis J, Klein, Eric A, Zheng, S Lilly, Witte, John S, Casey, Graham, Lubwama, Alex, Pooler, Loreall C, Sheng, Xin, Coetzee, Gerhard A, Cook, Michael B, Chanock, Stephen J, Stram, Daniel O, Watya, Stephen, Blot, William J, Conti, David V, Henderson, Brian E, and Haiman, Christopher A

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Clinical Research, Cancer, Prostate Cancer, Aging, Urologic Diseases, Human Genome, Prevention, Genetics, Aetiology, 2.1 Biological and endogenous factors, Black or African American, Aged, Aged, 80 and over, Case-Control Studies, Chromosomes, Human, Pair 8, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Prostatic Neoplasms, RNA, Long Noncoding, United States, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

The 8q24 region harbors multiple risk variants for distinct cancers, including >8 for prostate cancer. In this study, we conducted fine mapping of the 8q24 risk region (127.8-128.8Mb) in search of novel associations with common and rare variation in 4853 prostate cancer case patients and 4678 control subjects of African ancestry. All statistical tests were two-sided. We identified three independent associations at P values of less than 5.00×10(-8), all of which were replicated in studies from Ghana and Uganda (combined sample = 5869 case patients, 5615 control subjects; rs114798100: risk allele frequency [RAF] = 0.04, per-allele odds ratio [OR] = 2.31, 95% confidence interval [CI] = 2.04 to 2.61, P = 2.38×10(-40); rs72725879: RAF = 0.33, OR = 1.37, 95% CI = 1.30 to 1.45, P = 3.04×10(-27); and rs111906932: RAF = 0.03, OR = 1.79, 95% CI = 1.53 to 2.08, P = 1.39×10(-13)). Risk variants rs114798100 and rs111906923 are only found in men of African ancestry, with rs111906923 representing a novel association signal. The three variants are located within or near a number of prostate cancer-associated long noncoding RNAs (lncRNAs), including PRNCR1, PCAT1, and PCAT2. These findings highlight ancestry-specific risk variation and implicate prostate-specific lncRNAs at the 8q24 prostate cancer susceptibility region.

Published
2016

7. Prognostic impact of pre-transplant chromosomal aberrations in peripheral blood of patients undergoing unrelated donor hematopoietic cell transplant for acute myeloid leukemia

Author

Wang, Youjin, Zhou, Weiyin, McReynolds, Lisa J., Katki, Hormuzd A., Griffiths, Elizabeth A., Thota, Swapna, Machiela, Mitchell J., Yeager, Meredith, McCarthy, Philip, Pasquini, Marcelo, Wang, Junke, Karaesmen, Ezgi, Rizvi, Abbas, Preus, Leah, Tang, Hancong, Wang, Yiwen, Pooler, Loreall, Sheng, Xin, Haiman, Christopher A., Van Den Berg, David, Spellman, Stephen R., Wang, Tao, Kuxhausen, Michelle, Chanock, Stephen J., Lee, Stephanie J., Hahn, Theresa E., Sucheston-Campbell, Lara E., and Gadalla, Shahinaz M.

Published
2021
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8. Characterization of Large Structural Genetic Mosaicism in Human Autosomes

Author

Machiela, Mitchell J, Zhou, Weiyin, Sampson, Joshua N, Dean, Michael C, Jacobs, Kevin B, Black, Amanda, Brinton, Louise A, Chang, I-Shou, Chen, Chu, Chen, Constance, Chen, Kexin, Cook, Linda S, Bou, Marta Crous, De Vivo, Immaculata, Doherty, Jennifer, Friedenreich, Christine M, Gaudet, Mia M, Haiman, Christopher A, Hankinson, Susan E, Hartge, Patricia, Henderson, Brian E, Hong, Yun-Chul, Hosgood, H Dean, Hsiung, Chao A, Hu, Wei, Hunter, David J, Jessop, Lea, Kim, Hee Nam, Kim, Yeul Hong, Kim, Young Tae, Klein, Robert, Kraft, Peter, Lan, Qing, Lin, Dongxin, Liu, Jianjun, Le Marchand, Loic, Liang, Xiaolin, Lissowska, Jolanta, Lu, Lingeng, Magliocco, Anthony M, Matsuo, Keitaro, Olson, Sara H, Orlow, Irene, Park, Jae Yong, Pooler, Loreall, Prescott, Jennifer, Rastogi, Radhai, Risch, Harvey A, Schumacher, Fredrick, Seow, Adeline, Setiawan, Veronica Wendy, Shen, Hongbing, Sheng, Xin, Shin, Min-Ho, Shu, Xiao-Ou, Berg, David VanDen, Wang, Jiu-Cun, Wentzensen, Nicolas, Wong, Maria Pik, Wu, Chen, Wu, Tangchun, Wu, Yi-Long, Xia, Lucy, Yang, Hannah P, Yang, Pan-Chyr, Zheng, Wei, Zhou, Baosen, Abnet, Christian C, Albanes, Demetrius, Aldrich, Melinda C, Amos, Christopher, Amundadottir, Laufey T, Berndt, Sonja I, Blot, William J, Bock, Cathryn H, Bracci, Paige M, Burdett, Laurie, Buring, Julie E, Butler, Mary A, Carreón, Tania, Chatterjee, Nilanjan, Chung, Charles C, Cook, Michael B, Cullen, Michael, Davis, Faith G, Ding, Ti, Duell, Eric J, Epstein, Caroline G, Fan, Jin-Hu, Figueroa, Jonine D, Fraumeni, Joseph F, Freedman, Neal D, Fuchs, Charles S, Gao, Yu-Tang, Gapstur, Susan M, Patiño-Garcia, Ana, Garcia-Closas, Montserrat, Gaziano, J Michael, Giles, Graham G, and Gillanders, Elizabeth M

Subjects
Biological Sciences, Genetics, Human Genome, Clinical Research, 2.1 Biological and endogenous factors, Aetiology, Aged, Chromosome Aberrations, Female, Genome, Human, Genome-Wide Association Study, Genotype, Humans, Male, Middle Aged, Mosaicism, Neoplasms, Medical and Health Sciences, Genetics & Heredity, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

Analyses of genome-wide association study (GWAS) data have revealed that detectable genetic mosaicism involving large (>2 Mb) structural autosomal alterations occurs in a fraction of individuals. We present results for a set of 24,849 genotyped individuals (total GWAS set II [TGSII]) in whom 341 large autosomal abnormalities were observed in 168 (0.68%) individuals. Merging data from the new TGSII set with data from two prior reports (the Gene-Environment Association Studies and the total GWAS set I) generated a large dataset of 127,179 individuals; we then conducted a meta-analysis to investigate the patterns of detectable autosomal mosaicism (n = 1,315 events in 925 [0.73%] individuals). Restricting to events >2 Mb in size, we observed an increase in event frequency as event size decreased. The combined results underscore that the rate of detectable mosaicism increases with age (p value = 5.5 × 10(-31)) and is higher in men (p value = 0.002) but lower in participants of African ancestry (p value = 0.003). In a subset of 47 individuals from whom serial samples were collected up to 6 years apart, complex changes were noted over time and showed an overall increase in the proportion of mosaic cells as age increased. Our large combined sample allowed for a unique ability to characterize detectable genetic mosaicism involving large structural events and strengthens the emerging evidence of non-random erosion of the genome in the aging population.

Published
2015

9. Multiple functional variants in the IL1RL1 region are pretransplant markers for risk of GVHD and infection deaths

Author

Karaesmen, Ezgi, Hahn, Theresa, Dile, Alexander James, Rizvi, Abbas A., Wang, Junke, Wang, Tao, Haagenson, Michael D., Preus, Leah, Zhu, Qianqian, Liu, Qian, Yan, Li, Liu, Song, Haiman, Christopher A., Stram, Daniel, Pooler, Loreall, Sheng, Xin, Van Den Berg, David, Brock, Guy, Webb, Amy, McCarthy, Philip L., Pasquini, Marcelo C., Spellman, Stephen R., Lee, Stephanie J., Paczesny, Sophie, and Sucheston-Campbell, Lara E.

Published
2019
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10. Exome chip analyses identify genes affecting mortality after HLA-matched unrelated-donor blood and marrow transplantation

Author

Zhu, Qianqian, Yan, Li, Liu, Qian, Zhang, Chi, Wei, Lei, Hu, Qiang, Preus, Leah, Clay-Gilmour, Alyssa I., Onel, Kenan, Stram, Daniel O., Pooler, Loreall, Sheng, Xin, Haiman, Christopher A., Zhu, Xiaochun, Spellman, Stephen R., Pasquini, Marcelo, McCarthy, Philip L., Liu, Song, Hahn, Theresa, and Sucheston-Campbell, Lara E.

Published
2018
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11. Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21

Author

Haiman, Christopher A, Chen, Gary K, Blot, William J, Strom, Sara S, Berndt, Sonja I, Kittles, Rick A, Rybicki, Benjamin A, Isaacs, William B, Ingles, Sue A, Stanford, Janet L, Diver, W Ryan, Witte, John S, Hsing, Ann W, Nemesure, Barbara, Rebbeck, Timothy R, Cooney, Kathleen A, Xu, Jianfeng, Kibel, Adam S, Hu, Jennifer J, John, Esther M, Gueye, Serigne M, Watya, Stephen, Signorello, Lisa B, Hayes, Richard B, Wang, Zhaoming, Yeboah, Edward, Tettey, Yao, Cai, Qiuyin, Kolb, Suzanne, Ostrander, Elaine A, Zeigler-Johnson, Charnita, Yamamura, Yuko, Neslund-Dudas, Christine, Haslag-Minoff, Jennifer, Wu, William, Thomas, Venetta, Allen, Glenn O, Murphy, Adam, Chang, Bao-Li, Zheng, S Lilly, Leske, M Cristina, Wu, Suh-Yuh, Ray, Anna M, Hennis, Anselm JM, Thun, Michael J, Carpten, John, Casey, Graham, Carter, Erin N, Duarte, Edder R, Xia, Lucy Y, Sheng, Xin, Wan, Peggy, Pooler, Loreall C, Cheng, Iona, Monroe, Kristine R, Schumacher, Fredrick, Le Marchand, Loic, Kolonel, Laurence N, Chanock, Stephen J, Berg, David Van Den, Stram, Daniel O, and Henderson, Brian E

Subjects
Biological Sciences, Genetics, Human Genome, Aging, Urologic Diseases, Prevention, Prostate Cancer, Cancer, 2.1 Biological and endogenous factors, Aetiology, Black or African American, Chromosomes, Human, Pair 17, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Male, Polymorphism, Single Nucleotide, Prostatic Neoplasms, Medical and Health Sciences, Developmental Biology, Agricultural biotechnology, Bioinformatics and computational biology
Abstract

In search of common risk alleles for prostate cancer that could contribute to high rates of the disease in men of African ancestry, we conducted a genome-wide association study, with 1,047,986 SNP markers examined in 3,425 African-Americans with prostate cancer (cases) and 3,290 African-American male controls. We followed up the most significant 17 new associations from stage 1 in 1,844 cases and 3,269 controls of African ancestry. We identified a new risk variant on chromosome 17q21 (rs7210100, odds ratio per allele = 1.51, P = 3.4 × 10(-13)). The frequency of the risk allele is ∼5% in men of African descent, whereas it is rare in other populations (

Published
2011

12. Replication and validation of genetic polymorphisms associated with survival after allogeneic blood or marrow transplant

Author

Karaesmen, Ezgi, Rizvi, Abbas A., Preus, Leah M., McCarthy, Philip L., Pasquini, Marcelo C., Onel, Kenan, Zhu, Xiaochun, Spellman, Stephen, Haiman, Christopher A., Stram, Daniel O., Pooler, Loreall, Sheng, Xin, Zhu, Qianqian, Yan, Li, Liu, Qian, Hu, Qiang, Webb, Amy, Brock, Guy, Clay-Gilmour, Alyssa I., Battaglia, Sebastiano, Tritchler, David, Liu, Song, Hahn, Theresa, and Sucheston-Campbell, Lara E.

Published
2017
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13. Associations of minor histocompatibility antigens with outcomes following allogeneic hematopoietic cell transplantation

Author

Jadi, Othmane, primary, Tang, Hancong, additional, Olsen, Kelly, additional, Vensko, Steven, additional, Zhu, Qianqian, additional, Wang, Yiwen, additional, Haiman, Christopher A., additional, Pooler, Loreall, additional, Sheng, Xin, additional, Brock, Guy, additional, Webb, Amy, additional, Pasquini, Marcelo C., additional, McCarthy, Philip L., additional, Spellman, Stephen R., additional, Hahn, Theresa, additional, Vincent, Benjamin, additional, Armistead, Paul, additional, and Sucheston‐Campbell, Lara E., additional

Published
2023
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14. Supplementary Table 1 from Evaluating Genetic Risk for Prostate Cancer among Japanese and Latinos

Author

Cheng, Iona, primary, Chen, Gary K., primary, Nakagawa, Hidewaki, primary, He, Jing, primary, Wan, Peggy, primary, Laurie, Cathy C., primary, Shen, Jess, primary, Sheng, Xin, primary, Pooler, Loreall C., primary, Crenshaw, Andrew T., primary, Mirel, Daniel B., primary, Takahashi, Atsushi, primary, Kubo, Michiaki, primary, Nakamura, Yusuke, primary, Al Olama, Ali Amin, primary, Benlloch, Sara, primary, Donovan, Jenny L., primary, Guy, Michelle, primary, Hamdy, Freddie C., primary, Kote-Jarai, Zsofia, primary, Neal, David E., primary, Wilkens, Lynne R., primary, Monroe, Kristine R., primary, Stram, Daniel O., primary, Muir, Kenneth, primary, Eeles, Rosalind A., primary, Easton, Douglas F., primary, Kolonel, Laurence N., primary, Henderson, Brian E., primary, Le Marchand, Loïc, primary, and Haiman, Christopher A., primary

Published
2023
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15. Replication of associations between genetic polymorphisms and chronic graft-versus-host disease

Author

Martin, Paul J., Fan, Wenhong, Storer, Barry E., Levine, David M., Zhao, Lue Ping, Warren, Edus H., Flowers, Mary E.D., Lee, Stephanie J., Carpenter, Paul A., Boeckh, Michael, Hingorani, Sangeeta, Yan, Li, Hu, Qiang, Preus, Leah, Liu, Song, Spellman, Stephen, Zhu, Xiaochun, Pasquini, Marcelo, McCarthy, Philip, Stram, Daniel, Sheng, Xin, Pooler, Loreall, Haiman, Christopher A., Sucheston-Campbell, Lara, Hahn, Theresa, and Hansen, John A.

Published
2016
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17. Associations of Minor Histocompatibility Antigens with Clinical Outcomes Following Allogeneic Hematopoietic Cell Transplantation

Author

Jadi, Othmane, primary, Tang, Hancong, additional, Olsen, Kelly, additional, Vensko, Steven, additional, Zhu, Qianqian, additional, Wang, Yiwen, additional, Haiman, Christopher A, additional, Pooler, Loreall, additional, Sheng, Xin, additional, Brock, Guy, additional, Webb, Amy, additional, Pasquini, Marcelo, additional, McCarthy, Dr. Philip L., additional, Spellman, Stephen, additional, Hahn, Theresa E., additional, Vincent, Benjamin G, additional, Armistead, Paul M., additional, and Sucheston-Campbell, Lara, additional

Published
2023
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18. Shared Graft Versus Leukemia Minor Histocompatibility Antigens in Discovery-BMT

Author

Olsen, Kelly, primary, Jadi, Othmane, additional, Dexheimer, Sarah, additional, Bortone, Dante, additional, Vensko, Steven, additional, Tang, Hancong, additional, Diiorio, Marisa, additional, Saran, Tanvi, additional, Dingfelder, David, additional, Bennett, Sarah, additional, Zhu, Qianqian, additional, Wang, Yiwen, additional, Haiman, Christopher A, additional, Pooler, Loreall, additional, Sheng, Xin, additional, Webb, Amy, additional, Pasquini, Marcelo, additional, McCarthy, Dr. Philip L., additional, Spellman, Stephen, additional, Weimer, Eric, additional, Hahn, Theresa E., additional, Sucheston-Campbell, Lara, additional, Armistead, Paul M., additional, and Vincent, Benjamin G, additional

Published
2023
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19. Genome-wide association study of abdominal MRI-measured visceral fat: The multiethnic cohort adiposity phenotype study

Author

Streicher, Samantha A., primary, Lim, Unhee, additional, Park, S. Lani, additional, Li, Yuqing, additional, Sheng, Xin, additional, Hom, Victor, additional, Xia, Lucy, additional, Pooler, Loreall, additional, Shepherd, John, additional, Loo, Lenora W. M., additional, Ernst, Thomas, additional, Buchthal, Steven, additional, Franke, Adrian A., additional, Tiirikainen, Maarit, additional, Wilkens, Lynne R., additional, Haiman, Christopher A., additional, Stram, Daniel O., additional, Cheng, Iona, additional, and Le Marchand, Loïc, additional

Published
2023
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20. Shared graft-vs-leukemia minor histocompatibility antigens in DISCOVeRY-BMT

Author

Olsen, Kelly Shea, primary, Jadi, Othmane, additional, Dexheimer, Sarah, additional, Bortone, Dante S, additional, Vensko, Steven P, additional, Bennett, Sarah Nicole, additional, Tang, Hancong, additional, Diiorio, Marisa, additional, Saran, Tanvi, additional, Dingfelder, David, additional, Zhu, Qianqian, additional, Wang, Yiwen, additional, Haiman, Christopher A, additional, Pooler, Loreall, additional, Sheng, Xin, additional, Webb, Amy, additional, Pasquini, Marcelo C., additional, McCarthy, Philip L., additional, Spellman, Stephen R., additional, Weimer, Eric T., additional, Hahn, Theresa, additional, Sucheston-Campbell, Lara E, additional, Armistead, Paul M, additional, and Vincent, Benjamin, additional

Published
2022
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21. Associations of Minor Histocompatibility Antigens with Clinical Outcomes Following Allogeneic Hematopoietic Cell Transplantation

Author

Jadi, Othmane, primary, Tang, Hancong, additional, Olsen, Kelly Shea, additional, Vensko, Steven, additional, Zhu, Qianqian, additional, Wang, Yiwen, additional, Haiman, Christopher A., additional, Pooler, Loreall, additional, Sheng, Xin, additional, Brock, Guy, additional, Webb, Amy, additional, Pasquini, Marcelo C, additional, McCarthy, Philip L., additional, Spellman, Stephen R., additional, Hahn, Theresa E., additional, Vincent, Benjamin G., additional, Armistead, Paul M., additional, and Sucheston-Campbell, Lara E., additional

Published
2022
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22. Genome-Wide Non-HLA Mismatches Improve Risk Stratification for Overall Survival and Cause Specific Mortality after Unrelated Donor Allogeneic HCT

Author

Wang, Yiwen, primary, Wang, Junke, additional, Karaesmen, Ezgi, additional, Rizvi, Abbas A., additional, Clay-Gilmour, Alyssa I., additional, Zhu, Qianqian, additional, Pooler, Loreall, additional, Sheng, Xin, additional, Haiman, Christopher A., additional, Webb, Amy, additional, Brock, Guy, additional, Spellman, Stephen R., additional, McCarthy, Philip L., additional, Pasquini, Marcelo C, additional, Hahn, Theresa E., additional, and Sucheston-Campbell, Lara E., additional

Published
2022
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23. Clonal hematopoiesis and risk of prostate cancer in large samples of European ancestry men

Author

Wang, Anqi, primary, Xu, Yili, additional, Yu, Yao, additional, Nead, Kevin T, additional, Kim, TaeBeom, additional, Xu, Keren, additional, Dadaev, Tokhir, additional, Saunders, Ed, additional, Sheng, Xin, additional, Wan, Peggy, additional, Pooler, Loreall, additional, Xia, Lucy Y, additional, Chanock, Stephen, additional, Berndt, Sonja I, additional, Gapstur, Susan M, additional, Stevens, Victoria, additional, Albanes, Demetrius, additional, Weinstein, Stephanie J, additional, Gnanapragasam, Vincent, additional, Giles, Graham G, additional, Nguyen-Dumont, Tu, additional, Milne, Roger L, additional, Pomerantz, Mark M, additional, Schmidt, Julie A, additional, Stopsack, Konrad H, additional, Mucci, Lorelei A, additional, Catalona, William J, additional, Hetrick, Kurt N, additional, Doheny, Kimberly F, additional, MacInnis, Robert J, additional, Southey, Melissa C, additional, Eeles, Rosalind A, additional, Wiklund, Fredrik, additional, Kote-Jarai, Zsofia, additional, de Smith, Adam J, additional, Conti, David V, additional, Huff, Chad, additional, Haiman, Christopher A, additional, and Darst, Burcu F, additional

Published
2022
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24. Shared Graft Versus Leukemia Minor Histocompatibility Antigens in DISCOVeRY-BMT

Author

Olsen, Kelly S, primary, Jadi, Othmane, additional, Dexheimer, Sarah, additional, Bortone, Dante, additional, Vensko, Steven, additional, Bennett, Sarah, additional, Tang, Hancong, additional, Diiorio, Marisa, additional, Saran, Tanvi, additional, Dingfelder, David, additional, Zhu, Qianqian, additional, Wang, Yiwen, additional, Haiman, Christopher A, additional, Pooler, Loreall, additional, Sheng, Xin, additional, Webb, Amy, additional, Pasquini, Marcelo C, additional, McCarthy, Philip L, additional, Spellman, Stephen R, additional, Weimer, Eric, additional, Hahn, Theresa, additional, Sucheston-Campbell, Lara, additional, Armistead, Paul, additional, and Vincent, Benjamin, additional

Published
2022
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25. Abstract 688: Multi-stage exome sequencing study of 17,546 aggressive and non-aggressive prostate cancer cases

Author

Darst, Burcu F., primary, Saunders, Ed, additional, Dadaev, Tokhir, additional, Sheng, Xin, additional, Wan, Peggy, additional, Pooler, Loreall, additional, Xia, Lucy Y., additional, Chanock, Stephen, additional, Berndt, Sonja I., additional, Gapstur, Susan M., additional, Stevens, Victoria, additional, Albanes, Demetrius, additional, Weinstein, Stephanie J., additional, Gnanapragasam, Vincent, additional, Giles, Graham G., additional, Nguyen-Dumont, Tu, additional, Milne, Roger L., additional, Pomerantz, Mark M., additional, Schmidt, Julie A., additional, Travis, Ruth C., additional, Key, Timothy J., additional, Stopsack, Konrad H., additional, Mucci, Lorelei A., additional, Catalona, William J., additional, Marosy, Beth, additional, Hetrick, Kurt N., additional, Doheny, Kimberly F., additional, MacInnis, Robert J., additional, Southey, Melissa C., additional, Eeles, Rosalind A., additional, Wiklund, Fredrik, additional, Kote-Jarai, Zsofia, additional, Conti, David V., additional, and Haiman, Christopher A., additional

Published
2022
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26. A Rare Germline HOXB13 Variant Contributes to Risk of Prostate Cancer in Men of African Ancestry

Author

Darst, Burcu F., Hughley, Raymond, Pfennig, Aaron, Hazra, Ujani, Fan, Caoqi, Wan, Peggy, Sheng, Xin, Xia, Lucy, Andrews, Caroline, Chen, Fei, Berndt, Sonja I., Kote-Jarai, Zsofia, Govindasami, Koveela, Bensen, Jeannette T., Ingles, Sue A., Rybicki, Benjamin A., Nemesure, Barbara, John, Esther M., Fowke, Jay H., Huff, Chad D., Strom, Sara S., Isaacs, William B., Park, Jong Y., Zheng, Wei, Ostrander, Elaine A., Walsh, Patrick C., Carpten, John, Sellers, Thomas A., Yamoah, Kosj, Murphy, Adam B., Sanderson, Maureen, Crawford, Dana C., Gapstur, Susan M., Bush, William S., Aldrich, Melinda C., Cussenot, Olivier, Petrovics, Gyorgy, Cullen, Jennifer, Neslund-Dudas, Christine, Kittles, Rick A., Xu, Jianfeng, Stern, Mariana C., Chokkalingam, Anand P., Multigner, Luc, Parent, Marie-Elise, Menegaux, Florence, Cancel-Tassin, Geraldine, Kibel, Adam S., Klein, Eric A., Goodman, Phyllis J., Stanford, Janet L., Drake, Bettina F., Hu, Jennifer J., Clark, Peter E., Blanchet, Pascal, Casey, Graham, Hennis, Anselm J.M., Lubwama, Alexander, Thompson, Ian M., Jr, Leach, Robin J., Gundell, Susan M., Pooler, Loreall, Mohler, James L., Fontham, Elizabeth T.H., Smith, Gary J., Taylor, Jack A., Brureau, Laurent, Blot, William J., Biritwum, Richard, Tay, Evelyn, Truelove, Ann, Niwa, Shelley, Tettey, Yao, Varma, Rohit, McKean-Cowdin, Roberta, Torres, Mina, Jalloh, Mohamed, Magueye Gueye, Serigne, Niang, Lamine, Ogunbiyi, Olufemi, Oladimeji Idowu, Michael, Popoola, Olufemi, Adebiyi, Akindele O., Aisuodionoe-Shadrach, Oseremen I., Nwegbu, Maxwell, Adusei, Ben, Mante, Sunny, Darkwa-Abrahams, Afua, Yeboah, Edward D., Mensah, James E., Anthony Adjei, Andrew, Diop, Halimatou, Cook, Michael B., Chanock, Stephen J., Watya, Stephen, Eeles, Rosalind A., Chiang, Charleston W.K., Lachance, Joseph, Rebbeck, Timothy R., Conti, David V., and Haiman, Christopher A.

Published
2022
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27. Genome-wide association study of endometrial cancer in E2C2

Author

De Vivo, Immaculata, Prescott, Jennifer, Setiawan, Veronica Wendy, Olson, Sara H., Wentzensen, Nicolas, Attia, John, Black, Amanda, Brinton, Louise, Chen, Chu, Chen, Constance, Cook, Linda S., Crous-Bou, Marta, Doherty, Jennifer, Dunning, Alison M., Easton, Douglas F., Friedenreich, Christine M., Garcia-Closas, Montserrat, Gaudet, Mia M., Haiman, Christopher, Hankinson, Susan E., Hartge, Patricia, Henderson, Brian E., Holliday, Elizabeth, Horn-Ross, Pamela L., Hunter, David J., Le Marchand, Loic, Liang, Xiaolin, Lissowska, Jolanta, Long, Jirong, Lu, Lingeng, Magliocco, Anthony M., McEvoy, Mark, O’Mara, Tracy A., Orlow, Irene, Painter, Jodie N., Pooler, Loreall, Rastogi, Radhai, Rebbeck, Timothy R., Risch, Harvey, Sacerdote, Carlotta, Schumacher, Fredrick, Scott, Rodney J., Sheng, Xin, Shu, Xiao-ou, Spurdle, Amanda B., Thompson, Deborah, VanDen Berg, David, Weiss, Noel S., Xia, Lucy, Xiang, Yong-Bing, Yang, Hannah P., Yu, Herbert, Zheng, Wei, Chanock, Stephen, Kraft, Peter, and The Australian National Endometrial Cancer Study Group

Published
2014
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29. 168 - Impact of Common Graft Versus Leukemia Minor Histocompatibility Antigens on the Outcomes of Allogeneic Hematopoietic Cell Transplantation (alloHCT)

Author

Tang, Hancong, Olsen, Kelly, Jadi, Othmane, Wang, Junke, Wang, Yiwen, Entwistle, Sarah, Bortone, Dante, Vensko, Steven, Pooler, Loreall, Sheng, Xin, Haiman, Christopher A, Van Den Berg, David, Spellman, Stephen R., Wang, Tao, Hahn, Theresa E., Armistead, Paul M., Vincent, Benjamin G, and Sucheston-Campbell, Lara

Published
2021
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30. A genome-wide association study of breast cancer in women of African ancestry

Author

Chen, Fang, Chen, Gary K., Stram, Daniel O., Millikan, Robert C., Ambrosone, Christine B., John, Esther M., Bernstein, Leslie, Zheng, Wei, Palmer, Julie R., Hu, Jennifer J., Rebbeck, Tim R., Ziegler, Regina G., Nyante, Sarah, Bandera, Elisa V., Ingles, Sue A., Press, Michael F., Ruiz-Narvaez, Edward A., Deming, Sandra L., Rodriguez-Gil, Jorge L., DeMichele, Angela, Chanock, Stephen J., Blot, William, Signorello, Lisa, Cai, Qiuyin, Li, Guoliang, Long, Jirong, Huo, Dezheng, Zheng, Yonglan, Cox, Nancy J., Olopade, Olufunmilayo I., Ogundiran, Temidayo O., Adebamowo, Clement, Nathanson, Katherine L., Domchek, Susan M., Simon, Michael S., Hennis, Anselm, Nemesure, Barbara, Wu, Suh-Yuh, Leske, M. Cristina, Ambs, Stefan, Hutter, Carolyn M., Young, Alicia, Kooperberg, Charles, Peters, Ulrike, Rhie, Suhn K., Wan, Peggy, Sheng, Xin, Pooler, Loreall C., Van Den Berg, David J., Le Marchand, Loic, Kolonel, Laurence N., Henderson, Brian E., and Haiman, Christopher A.

Published
2013
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31. Genome-wide association study of pancreatic fat: The Multiethnic Cohort Adiposity Phenotype Study

Author

Streicher, Samantha A., primary, Lim, Unhee, additional, Park, S. Lani, additional, Li, Yuqing, additional, Sheng, Xin, additional, Hom, Victor, additional, Xia, Lucy, additional, Pooler, Loreall, additional, Shepherd, John, additional, Loo, Lenora W. M., additional, Darst, Burcu F., additional, Highland, Heather M., additional, Polfus, Linda M., additional, Bogumil, David, additional, Ernst, Thomas, additional, Buchthal, Steven, additional, Franke, Adrian A., additional, Setiawan, Veronica Wendy, additional, Tiirikainen, Maarit, additional, Wilkens, Lynne R., additional, Haiman, Christopher A., additional, Stram, Daniel O., additional, Cheng, Iona, additional, and Le Marchand, Loïc, additional

Published
2021
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32. Genome-Wide Association Analyses Identify Variants in IRF4 Associated With Acute Myeloid Leukemia and Myelodysplastic Syndrome Susceptibility

Author

Wang, Junke, primary, Clay-Gilmour, Alyssa I., additional, Karaesmen, Ezgi, additional, Rizvi, Abbas, additional, Zhu, Qianqian, additional, Yan, Li, additional, Preus, Leah, additional, Liu, Song, additional, Wang, Yiwen, additional, Griffiths, Elizabeth, additional, Stram, Daniel O., additional, Pooler, Loreall, additional, Sheng, Xin, additional, Haiman, Christopher, additional, Van Den Berg, David, additional, Webb, Amy, additional, Brock, Guy, additional, Spellman, Stephen, additional, Pasquini, Marcelo, additional, McCarthy, Philip, additional, Allan, James, additional, Stölzel, Friedrich, additional, Onel, Kenan, additional, Hahn, Theresa, additional, and Sucheston-Campbell, Lara E., additional

Published
2021
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33. Mendelian randomization analyses suggest a role for cholesterol in the development of endometrial cancer

Author

Kho, Pik Fang, Amant, Frederic, Annibali, Daniela, Ashton, Katie, Attia, John, Auer, Paul L., Beckmann, Matthias W., Black, Amanda, Brinton, Louise, Buchanan, Daniel D., Chanock, Stephen J., Chen, Chu, Chen, Maxine M., Cheng, Timothy H.T., Cook, Linda S., Crous-Bous, Marta, Czene, Kamila, De Vivo, Immaculata, Dennis, Joe, Dörk, Thilo, Dowdy, Sean C., Dunning, Alison M., Dürst, Matthias, Easton, Douglas F., Ekici, Arif B., Fasching, Peter A., Fridley, Brooke L., Friedenreich, Christine M., García-Closas, Montserrat, Gaudet, Mia M., Giles, Graham G., Goode, Ellen L., Gorman, Maggie, Haiman, Christopher A., Hall, Per, Hankinson, Susan E., Hein, Alexander, Hillemanns, Peter, Hodgson, Shirley, Hoivik, Erling A., Holliday, Elizabeth G., Hunter, David J., Jones, Angela M., Kraft, Peter, Krakstad, Camilla, Lambrechts, Diether, Le Marchand, Loic, Liang, Xiaolin, Lindblom, Annika, Lissowska, Jolanta, Long, Jirong, Lu, Lingeng, Magliocco, Anthony M., Martin, Lynn, McEvoy, Mark, Milne, Roger L., Mints, Miriam, Nassir, Rami, Otton, Geoffrey, Palles, Claire, Pooler, Loreall, Proietto, Tony, Rebbeck, Timothy R., Renner, Stefan P., Risch, Harvey A., Rübner, Matthias, Runnebaum, Ingo, Sacerdote, Carlotta, Sarto, Gloria E., Schumacher, Fredrick, Scott, Rodney J., Setiawan, V. Wendy, Shah, Mitul, Sheng, Xin, Shu, Xiao Ou, Southey, Melissa C., Tham, Emma, Tomlinson, Ian, Trovik, Jone, Turman, Constance, Tyrer, Jonathan P., Van Den Berg, David, Wang, Zhaoming, Wentzensen, Nicolas, Xia, Lucy, Xiang, Yong Bing, Yang, Hannah P., Yu, Herbert, Zheng, Wei, Webb, Penelope M., Thompson, Deborah J., Spurdle, Amanda B., Glubb, Dylan M., O'Mara, Tracy A., Kho, Pik Fang, Amant, Frederic, Annibali, Daniela, Ashton, Katie, Attia, John, Auer, Paul L., Beckmann, Matthias W., Black, Amanda, Brinton, Louise, Buchanan, Daniel D., Chanock, Stephen J., Chen, Chu, Chen, Maxine M., Cheng, Timothy H.T., Cook, Linda S., Crous-Bous, Marta, Czene, Kamila, De Vivo, Immaculata, Dennis, Joe, Dörk, Thilo, Dowdy, Sean C., Dunning, Alison M., Dürst, Matthias, Easton, Douglas F., Ekici, Arif B., Fasching, Peter A., Fridley, Brooke L., Friedenreich, Christine M., García-Closas, Montserrat, Gaudet, Mia M., Giles, Graham G., Goode, Ellen L., Gorman, Maggie, Haiman, Christopher A., Hall, Per, Hankinson, Susan E., Hein, Alexander, Hillemanns, Peter, Hodgson, Shirley, Hoivik, Erling A., Holliday, Elizabeth G., Hunter, David J., Jones, Angela M., Kraft, Peter, Krakstad, Camilla, Lambrechts, Diether, Le Marchand, Loic, Liang, Xiaolin, Lindblom, Annika, Lissowska, Jolanta, Long, Jirong, Lu, Lingeng, Magliocco, Anthony M., Martin, Lynn, McEvoy, Mark, Milne, Roger L., Mints, Miriam, Nassir, Rami, Otton, Geoffrey, Palles, Claire, Pooler, Loreall, Proietto, Tony, Rebbeck, Timothy R., Renner, Stefan P., Risch, Harvey A., Rübner, Matthias, Runnebaum, Ingo, Sacerdote, Carlotta, Sarto, Gloria E., Schumacher, Fredrick, Scott, Rodney J., Setiawan, V. Wendy, Shah, Mitul, Sheng, Xin, Shu, Xiao Ou, Southey, Melissa C., Tham, Emma, Tomlinson, Ian, Trovik, Jone, Turman, Constance, Tyrer, Jonathan P., Van Den Berg, David, Wang, Zhaoming, Wentzensen, Nicolas, Xia, Lucy, Xiang, Yong Bing, Yang, Hannah P., Yu, Herbert, Zheng, Wei, Webb, Penelope M., Thompson, Deborah J., Spurdle, Amanda B., Glubb, Dylan M., and O'Mara, Tracy A.

Abstract

Blood lipids have been associated with the development of a range of cancers, including breast, lung and colorectal cancer. For endometrial cancer, observational studies have reported inconsistent associations between blood lipids and cancer risk. To reduce biases from unmeasured confounding, we performed a bidirectional, two-sample Mendelian randomization analysis to investigate the relationship between levels of three blood lipids (low-density lipoprotein [LDL] and high-density lipoprotein [HDL] cholesterol, and triglycerides) and endometrial cancer risk. Genetic variants associated with each of these blood lipid levels (P < 5 × 10−8) were identified as instrumental variables, and assessed using genome-wide association study data from the Endometrial Cancer Association Consortium (12 906 cases and 108 979 controls) and the Global Lipids Genetic Consortium (n = 188 578). Mendelian randomization analyses found genetically raised LDL cholesterol levels to be associated with lower risks of endometrial cancer of all histologies combined, and of endometrioid and non-endometrioid subtypes. Conversely, higher genetically predicted HDL cholesterol levels were associated with increased risk of non-endometrioid endometrial cancer. After accounting for the potential confounding role of obesity (as measured by genetic variants associated with body mass index), the association between genetically predicted increased LDL cholesterol levels and lower endometrial cancer risk remained significant, especially for non-endometrioid endometrial cancer. There was no evidence to support a role for triglycerides in endometrial cancer development. Our study supports a role for LDL and HDL cholesterol in the development of non-endometrioid endometrial cancer. Further studies are required to understand the mechanisms underlying these findings.

Published
2021

35. Genome-wide Association Study of Pancreatic Fat: The Multiethnic Cohort Adiposity Phenotype Study

Author

Streicher, Samantha A, primary, Lim, Unhee, additional, Park, S. Lani, additional, Li, Yuqing, additional, Sheng, Xin, additional, Hom, Victor, additional, Xia, Lucy, additional, Pooler, Loreall, additional, Shepherd, John, additional, Loo, Lenora WM, additional, Darst, Burcu F, additional, Highland, Heather M, additional, Polfus, Linda M, additional, Bogumil, David, additional, Ernst, Thomas, additional, Buchthal, Steven, additional, Franke, Adrian A, additional, Setiawan, Veronica Wendy, additional, Tiirikainen, Maarit, additional, Wilkens, Lynne R, additional, Haiman, Christopher A, additional, Stram, Daniel O, additional, Cheng, Iona, additional, and Marchand, Loïc Le, additional

Published
2021
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36. Impact of Common Graft Versus Leukemia Minor Histocompatibility Antigens on the Outcomes of Allogeneic Hematopoietic Cell Transplantation (alloHCT)

Author

Tang, Hancong, primary, Olsen, Kelly, additional, Jadi, Othmane, additional, Wang, Junke, additional, Wang, Yiwen, additional, Entwistle, Sarah, additional, Bortone, Dante, additional, Vensko, Steven, additional, Pooler, Loreall, additional, Sheng, Xin, additional, Haiman, Christopher A, additional, Van Den Berg, David, additional, Spellman, Stephen R., additional, Wang, Tao, additional, Hahn, Theresa E., additional, Armistead, Paul M., additional, Vincent, Benjamin G, additional, and Sucheston-Campbell, Lara, additional

Published
2021
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37. Genome-Wide Non-HLA Mismatches Correlate with Overall Survival and Cause Specific Mortality after Unrelated Donor Allogeneic HCT

Author

Wang, Yiwen, primary, Karaesmen, Ezgi, additional, Wang, Junke, additional, Tang, Hancong, additional, Rizvi, Abbas, additional, Zhu, Qianqian, additional, Yan, Li, additional, Preus, Leah, additional, Liu, Song, additional, Pooler, Loreall, additional, Sheng, Xin, additional, Haiman, Christopher A, additional, Van Den Berg, David, additional, Brock, Guy, additional, Webb, Amy, additional, Spellman, Stephen R., additional, Pasquini, Marcelo C., additional, McCarthy, Philip L., additional, Clay-Gilmour, Alyssa, additional, Hahn, Theresa E., additional, and Sucheston-Campbell, Lara, additional

Published
2021
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38. 72 - Shared Graft Versus Leukemia Minor Histocompatibility Antigens in Discovery-BMT

Author

Olsen, Kelly, Jadi, Othmane, Dexheimer, Sarah, Bortone, Dante, Vensko, Steven, Tang, Hancong, Diiorio, Marisa, Saran, Tanvi, Dingfelder, David, Bennett, Sarah, Zhu, Qianqian, Wang, Yiwen, Haiman, Christopher A, Pooler, Loreall, Sheng, Xin, Webb, Amy, Pasquini, Marcelo, McCarthy, Dr. Philip L., Spellman, Stephen, Weimer, Eric, Hahn, Theresa E., Sucheston-Campbell, Lara, Armistead, Paul M., and Vincent, Benjamin G

Published
2023
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39. 31 - Associations of Minor Histocompatibility Antigens with Clinical Outcomes Following Allogeneic Hematopoietic Cell Transplantation

Author

Jadi, Othmane, Tang, Hancong, Olsen, Kelly, Vensko, Steven, Zhu, Qianqian, Wang, Yiwen, Haiman, Christopher A, Pooler, Loreall, Sheng, Xin, Brock, Guy, Webb, Amy, Pasquini, Marcelo, McCarthy, Dr. Philip L., Spellman, Stephen, Hahn, Theresa E., Vincent, Benjamin G, Armistead, Paul M., and Sucheston-Campbell, Lara

Published
2023
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40. Associations of Clinical Outcomes after Allogeneic Hematopoietic Cell Transplantation with Number of Predicted Class II Restricted mHA

Author

Jadi, Othmane, primary, Tang, Hancong, additional, Wang, Junke, additional, Bortone, Dante, additional, Vensko, Steven, additional, Pooler, Loreall, additional, Sheng, Xin, additional, Haiman, Christopher A., additional, Van Den Berg, David, additional, Spellman, Stephen R., additional, Pasquini, Marcelo C., additional, Hahn, Theresa E., additional, Armistead, Paul M., additional, Vincent, Benjamin G., additional, and Sucheston-Campbell, Lara E., additional

Published
2020
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41. Pre-Transplant Clonal Mosaicism Is Associated with Increased Relapse and Lower Survival in Acute Lymphoblastic Leukemia Patients Undergoing Allogeneic Hematopoietic Cell Transplant

Author

Wang, Yiwen, primary, Zhou, Weiyin, additional, Wang, Junke, additional, Karaesmen, Ezgi, additional, Tang, Hancong, additional, McCarthy, Philip L., additional, Pasquini, Marcelo C., additional, Wang, Youjin, additional, McReynolds, Lisa J., additional, Katki, Hormuzd, additional, Machiela, Mitchell, additional, Yeager, Meredith, additional, Pooler, Loreall, additional, Sheng, Xin, additional, Haiman, Christopher, additional, Van Den Berg, David, additional, Spellman, Stephen R., additional, Wang, Tao, additional, Kuxhausen, Michelle, additional, Chanock, Stephen J., additional, Lee, Stephanie J., additional, Clay-Gilmour, Alyssa I., additional, Hahn, Theresa E., additional, Gadalla, Shahinaz M, additional, and Sucheston-Campbell, Lara E., additional

Published
2020
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42. Meta-Analysis of Genome-Wide Association Studies of Acute Myeloid Leukemia (AML) Patients Identifies Variants Associated with Risk of 11q23/KMT2A-Translocated and Core-Binding Factor (CBF) AML and Suggests a Role for Transcription Elongation in Leukemogenesis

Author

Walker, Christopher J., primary, Wang, Junke, additional, Clay-Gilmour, Alyssa I., additional, Mrózek, Krzysztof, additional, Nicolet, Deedra, additional, Oakes, Christopher C., additional, Kohlschmidt, Jessica, additional, Powell, Bayard L., additional, Kolitz, Jonathan E., additional, Carroll, Andrew J, additional, Karaesmen, Ezgi, additional, Rizvi, Abbas A., additional, Zhu, Qianqian, additional, Yan, Li, additional, Preus, Leah, additional, Liu, Song, additional, Wang, Yiwen, additional, Stram, Daniel O., additional, Pooler, Loreall, additional, Sheng, Xin, additional, Haiman, Christopher, additional, Van Den Berg, David, additional, Webb, Amy, additional, Brock, Guy, additional, Spellman, Stephen R., additional, Pasquini, Marcelo C., additional, McCarthy, Philip L., additional, Allan, James M., additional, Stolzel, Friedrich, additional, Onel, Kenan, additional, Stone, Richard M., additional, Garzon, Ramiro, additional, Bloomfield, Clara D., additional, Byrd, John C., additional, de la Chapelle, Albert, additional, Hahn, Theresa E., additional, Eisfeld, Ann-Kathrin, additional, and Sucheston-Campbell, Lara E., additional

Published
2020
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43. A Germline Variant at 8q24 Contributes to Familial Clustering of Prostate Cancer in Men of African Ancestry

Author

Darst, Burcu F., primary, Wan, Peggy, additional, Sheng, Xin, additional, Bensen, Jeannette T., additional, Ingles, Sue A., additional, Rybicki, Benjamin A., additional, Nemesure, Barbara, additional, John, Esther M., additional, Fowke, Jay H., additional, Stevens, Victoria L., additional, Berndt, Sonja I., additional, Huff, Chad D., additional, Strom, Sara S., additional, Park, Jong Y., additional, Zheng, Wei, additional, Ostrander, Elaine A., additional, Walsh, Patrick C., additional, Srivastava, Shiv, additional, Carpten, John, additional, Sellers, Thomas A., additional, Yamoah, Kosj, additional, Murphy, Adam B., additional, Sanderson, Maureen, additional, Crawford, Dana C., additional, Gapstur, Susan M., additional, Bush, William S., additional, Aldrich, Melinda C., additional, Cussenot, Olivier, additional, Yeager, Meredith, additional, Petrovics, Gyorgy, additional, Cullen, Jennifer, additional, Neslund-Dudas, Christine, additional, Kittles, Rick A., additional, Xu, Jianfeng, additional, Stern, Mariana C., additional, Kote-Jarai, Zsofia, additional, Govindasami, Koveela, additional, Chokkalingam, Anand P., additional, Multigner, Luc, additional, Parent, Marie-Elise, additional, Menegaux, Florence, additional, Cancel-Tassin, Geraldine, additional, Kibel, Adam S., additional, Klein, Eric A., additional, Goodman, Phyllis J., additional, Drake, Bettina F., additional, Hu, Jennifer J., additional, Clark, Peter E., additional, Blanchet, Pascal, additional, Casey, Graham, additional, Hennis, Anselm J.M., additional, Lubwama, Alexander, additional, Thompson, Ian M., additional, Leach, Robin, additional, Gundell, Susan M., additional, Pooler, Loreall, additional, Xia, Lucy, additional, Mohler, James L., additional, Fontham, Elizabeth T.H., additional, Smith, Gary J., additional, Taylor, Jack A., additional, Eeles, Rosalind A., additional, Brureau, Laurent, additional, Chanock, Stephen J., additional, Watya, Stephen, additional, Stanford, Janet L., additional, Mandal, Diptasri, additional, Isaacs, William B., additional, Cooney, Kathleen, additional, Blot, William J., additional, Conti, David V., additional, and Haiman, Christopher A., additional

Published
2020
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44. Germline Sequencing DNA Repair Genes in 5545 Men With Aggressive and Nonaggressive Prostate Cancer

Author

Darst, Burcu F, primary, Dadaev, Tokhir, additional, Saunders, Ed, additional, Sheng, Xin, additional, Wan, Peggy, additional, Pooler, Loreall, additional, Xia, Lucy Y, additional, Chanock, Stephen, additional, Berndt, Sonja I, additional, Gapstur, Susan M, additional, Stevens, Victoria, additional, Albanes, Demetrius, additional, Weinstein, Stephanie J, additional, Gnanapragasam, Vincent, additional, Giles, Graham G, additional, Nguyen-Dumont, Tu, additional, Milne, Roger L, additional, Pomerantz, Mark, additional, Schmidt, Julie A, additional, Mucci, Lorelei, additional, Catalona, William J, additional, Hetrick, Kurt N, additional, Doheny, Kimberly F, additional, MacInnis, Robert J, additional, Southey, Melissa C, additional, Eeles, Rosalind A, additional, Wiklund, Fredrik, additional, Kote-Jarai, Zsofia, additional, Conti, David V, additional, and Haiman, Christopher A, additional

Published
2020
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45. Mendelian randomization analyses suggest a role for cholesterol in the development of endometrial cancer

Author

Kho, Pik‐Fang, primary, Amant, Frederic, additional, Annibali, Daniela, additional, Ashton, Katie, additional, Attia, John, additional, Auer, Paul L., additional, Beckmann, Matthias W., additional, Black, Amanda, additional, Brinton, Louise, additional, Buchanan, Daniel D., additional, Chanock, Stephen J., additional, Chen, Chu, additional, Chen, Maxine M., additional, Cheng, Timothy H. T., additional, Cook, Linda S., additional, Crous‐Bous, Marta, additional, Czene, Kamila, additional, De Vivo, Immaculata, additional, Dennis, Joe, additional, Dörk, Thilo, additional, Dowdy, Sean C., additional, Dunning, Alison M., additional, Dürst, Matthias, additional, Easton, Douglas F., additional, Ekici, Arif B., additional, Fasching, Peter A., additional, Fridley, Brooke L., additional, Friedenreich, Christine M., additional, García‐Closas, Montserrat, additional, Gaudet, Mia M., additional, Giles, Graham G., additional, Goode, Ellen L., additional, Gorman, Maggie, additional, Haiman, Christopher A., additional, Hall, Per, additional, Hankinson, Susan E., additional, Hein, Alexander, additional, Hillemanns, Peter, additional, Hodgson, Shirley, additional, Hoivik, Erling A., additional, Holliday, Elizabeth G., additional, Hunter, David J., additional, Jones, Angela, additional, Kraft, Peter, additional, Krakstad, Camilla, additional, Lambrechts, Diether, additional, Le Marchand, Loic, additional, Liang, Xiaolin, additional, Lindblom, Annika, additional, Lissowska, Jolanta, additional, Long, Jirong, additional, Lu, Lingeng, additional, Magliocco, Anthony M., additional, Martin, Lynn, additional, McEvoy, Mark, additional, Milne, Roger L., additional, Mints, Miriam, additional, Nassir, Rami, additional, Otton, Geoffrey, additional, Palles, Claire, additional, Pooler, Loreall, additional, Proietto, Tony, additional, Rebbeck, Timothy R., additional, Renner, Stefan P., additional, Risch, Harvey A., additional, Rübner, Matthias, additional, Runnebaum, Ingo, additional, Sacerdote, Carlotta, additional, Sarto, Gloria E., additional, Schumacher, Fredrick, additional, Scott, Rodney J., additional, Setiawan, V. Wendy, additional, Shah, Mitul, additional, Sheng, Xin, additional, Shu, Xiao‐Ou, additional, Southey, Melissa C., additional, Tham, Emma, additional, Tomlinson, Ian, additional, Trovik, Jone, additional, Turman, Constance, additional, Tyrer, Jonathan P., additional, Van Den Berg, David, additional, Wang, Zhaoming, additional, Wentzensen, Nicolas, additional, Xia, Lucy, additional, Xiang, Yong‐Bing, additional, Yang, Hannah P., additional, Yu, Herbert, additional, Zheng, Wei, additional, Webb, Penelope M., additional, Thompson, Deborah J., additional, Spurdle, Amanda B., additional, Glubb, Dylan M., additional, and O'Mara, Tracy A., additional

Published
2020
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46. The Four-Kallikrein Panel Is Effective in Identifying Aggressive Prostate Cancer in a Multiethnic Population

Author

Darst, Burcu F., primary, Chou, Alisha, additional, Wan, Peggy, additional, Pooler, Loreall, additional, Sheng, Xin, additional, Vertosick, Emily A., additional, Conti, David V., additional, Wilkens, Lynne R., additional, Le Marchand, Loïc, additional, Vickers, Andrew J., additional, Lilja, Hans G., additional, and Haiman, Christopher A., additional

Published
2020
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47. Genome‐Wide Association Study of Liver Fat: The Multiethnic Cohort Adiposity Phenotype Study

Author

Park, S. Lani, primary, Li, Yuqing, additional, Sheng, Xin, additional, Hom, Victor, additional, Xia, Lucy, additional, Zhao, Kechen, additional, Pooler, Loreall, additional, Setiawan, V. Wendy, additional, Lim, Unhee, additional, Monroe, Kristine R., additional, Wilkens, Lynne R., additional, Kristal, Bruce S., additional, Lampe, Johanna W., additional, Hullar, Meredith, additional, Shepherd, John, additional, Loo, Lenora L. M., additional, Ernst, Thomas, additional, Franke, Adrian A., additional, Tiirikainen, Maarit, additional, Haiman, Christopher A., additional, Stram, Daniel O., additional, Le Marchand, Loïc, additional, and Cheng, Iona, additional

Published
2020
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48. Population-specific reference panels are crucial for genetic analyses: an example of the CREBRF locus in Native Hawaiians

Author

Lin, Meng, primary, Caberto, Christian, additional, Wan, Peggy, additional, Li, Yuqing, additional, Lum-Jones, Annette, additional, Tiirikainen, Maarit, additional, Pooler, Loreall, additional, Nakamura, Brooke, additional, Sheng, Xin, additional, Porcel, Jacqueline, additional, Lim, Unhee, additional, Setiawan, Veronica Wendy, additional, Le Marchand, Loïc, additional, Wilkens, Lynne R, additional, Haiman, Christopher A, additional, Cheng, Iona, additional, and Chiang, Charleston W K, additional

Published
2020
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49. Prognostic Impact of Pre-Transplant Chromosomal Aberrations Detected By SNP-Array in Patients Undergoing Unrelated Donor Hematopoietic Cell Transplant for Acute Myeloid Leukemia

Author

Wang, Youjin, primary, Zhou, Weiyin, additional, McReynolds, Lisa J., additional, Griffiths, Elizabeth A, additional, Thota, Swapna, additional, Machiela, Mitchell J., additional, Chanock, Stephen J, additional, Yeager, Meredith, additional, McCarthy, Philip L., additional, Pasquini, Marcelo C., additional, Wang, Junke, additional, Karaesmen, Ezgi, additional, Rizvi, Abbas, additional, Preus, Leah, additional, Tang, Hancong, additional, Wang, Yiwen, additional, Stram, Daniel O., additional, Pooler, Loreall, additional, Sheng, Xin, additional, Haiman, Christopher A., additional, Van Den Berg, David, additional, Spellman, Stephen R., additional, Wang, Tao, additional, Kuxhausen, Michelle, additional, Lee, Stephanie, additional, Hahn, Theresa E., additional, Sucheston-Campbell, Lara, additional, and Gadalla, Shahinaz M., additional

Published
2020
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50. Genetic analyses of diverse populations improves discovery for complex traits.

Author

Wojcik, Genevieve, Wojcik, Genevieve, Graff, Mariaelisa, Nishimura, Katherine, Tao, Ran, Haessler, Jeffrey, Gignoux, Christopher, Highland, Heather, Patel, Yesha, Sorokin, Elena, Avery, Christy, Belbin, Gillian, Bien, Stephanie, Cheng, Iona, Cullina, Sinead, Hodonsky, Chani, Hu, Yao, Huckins, Laura, Jeff, Janina, Justice, Anne, Kocarnik, Jonathan, Lim, Unhee, Lin, Bridget, Lu, Yingchang, Nelson, Sarah, Park, Sung-Shim, Poisner, Hannah, Preuss, Michael, Richard, Melissa, Schurmann, Claudia, Setiawan, Veronica, Sockell, Alexandra, Vahi, Karan, Verbanck, Marie, Vishnu, Abhishek, Walker, Ryan, Young, Kristin, Zubair, Niha, Acuña-Alonso, Victor, Ambite, Jose, Barnes, Kathleen, Boerwinkle, Eric, Bottinger, Erwin, Bustamante, Carlos, Caberto, Christian, Canizales-Quinteros, Samuel, Conomos, Matthew, Deelman, Ewa, Do, Ron, Doheny, Kimberly, Fernández-Rhodes, Lindsay, Fornage, Myriam, Hailu, Benyam, Heiss, Gerardo, Hindorff, Lucia, Jackson, Rebecca, Laurie, Cecelia, Laurie, Cathy, Li, Yuqing, Lin, Dan-Yu, Moreno-Estrada, Andres, Nadkarni, Girish, Norman, Paul, Pooler, Loreall, Reiner, Alexander, Romm, Jane, Sabatti, Chiara, Sandoval, Karla, Sheng, Xin, Stahl, Eli, Stram, Daniel, Thornton, Timothy, Wassel, Christina, Wilkens, Lynne, Winkler, Cheryl, Yoneyama, Sachi, Buyske, Steven, Haiman, Christopher, Kooperberg, Charles, Le Marchand, Loic, Loos, Ruth, Matise, Tara, North, Kari, Peters, Ulrike, Kenny, Eimear, Carlson, Christopher, Henn, Brenna, Wojcik, Genevieve, Wojcik, Genevieve, Graff, Mariaelisa, Nishimura, Katherine, Tao, Ran, Haessler, Jeffrey, Gignoux, Christopher, Highland, Heather, Patel, Yesha, Sorokin, Elena, Avery, Christy, Belbin, Gillian, Bien, Stephanie, Cheng, Iona, Cullina, Sinead, Hodonsky, Chani, Hu, Yao, Huckins, Laura, Jeff, Janina, Justice, Anne, Kocarnik, Jonathan, Lim, Unhee, Lin, Bridget, Lu, Yingchang, Nelson, Sarah, Park, Sung-Shim, Poisner, Hannah, Preuss, Michael, Richard, Melissa, Schurmann, Claudia, Setiawan, Veronica, Sockell, Alexandra, Vahi, Karan, Verbanck, Marie, Vishnu, Abhishek, Walker, Ryan, Young, Kristin, Zubair, Niha, Acuña-Alonso, Victor, Ambite, Jose, Barnes, Kathleen, Boerwinkle, Eric, Bottinger, Erwin, Bustamante, Carlos, Caberto, Christian, Canizales-Quinteros, Samuel, Conomos, Matthew, Deelman, Ewa, Do, Ron, Doheny, Kimberly, Fernández-Rhodes, Lindsay, Fornage, Myriam, Hailu, Benyam, Heiss, Gerardo, Hindorff, Lucia, Jackson, Rebecca, Laurie, Cecelia, Laurie, Cathy, Li, Yuqing, Lin, Dan-Yu, Moreno-Estrada, Andres, Nadkarni, Girish, Norman, Paul, Pooler, Loreall, Reiner, Alexander, Romm, Jane, Sabatti, Chiara, Sandoval, Karla, Sheng, Xin, Stahl, Eli, Stram, Daniel, Thornton, Timothy, Wassel, Christina, Wilkens, Lynne, Winkler, Cheryl, Yoneyama, Sachi, Buyske, Steven, Haiman, Christopher, Kooperberg, Charles, Le Marchand, Loic, Loos, Ruth, Matise, Tara, North, Kari, Peters, Ulrike, Kenny, Eimear, Carlson, Christopher, and Henn, Brenna

Abstract

Genome-wide association studies (GWAS) have laid the foundation for investigations into the biology of complex traits, drug development and clinical guidelines. However, the majority of discovery efforts are based on data from populations of European ancestry1-3. In light of the differential genetic architecture that is known to exist between populations, bias in representation can exacerbate existing disease and healthcare disparities. Critical variants may be missed if they have a low frequency or are completely absent in European populations, especially as the field shifts its attention towards rare variants, which are more likely to be population-specific4-10. Additionally, effect sizes and their derived risk prediction scores derived in one population may not accurately extrapolate to other populations11,12. Here we demonstrate the value of diverse, multi-ethnic participants in large-scale genomic studies. The Population Architecture using Genomics and Epidemiology (PAGE) study conducted a GWAS of 26 clinical and behavioural phenotypes in 49,839 non-European individuals. Using strategies tailored for analysis of multi-ethnic and admixed populations, we describe a framework for analysing diverse populations, identify 27 novel loci and 38 secondary signals at known loci, as well as replicate 1,444 GWAS catalogue associations across these traits. Our data show evidence of effect-size heterogeneity across ancestries for published GWAS associations, substantial benefits for fine-mapping using diverse cohorts and insights into clinical implications. In the United States-where minority populations have a disproportionately higher burden of chronic conditions13-the lack of representation of diverse populations in genetic research will result in inequitable access to precision medicine for those with the highest burden of disease. We strongly advocate for continued, large genome-wide efforts in diverse populations to maximize genetic discovery and reduce health dis

Published
2019

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