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17 results on '"Poon, Maya M.L."'

1. Site-specific development and progressive maturation of human tissue-resident memory T cells over infancy and childhood

Author

Connors, Thomas J., Matsumoto, Rei, Verma, Shivali, Szabo, Peter A., Guyer, Rebecca, Gray, Joshua, Wang, Zicheng, Thapa, Puspa, Dogra, Pranay, Poon, Maya M.L., Rybkina, Ksenia, Bradley, Marissa C., Idzikowski, Emma, McNichols, James, Kubota, Masaru, Pethe, Kalpana, Shen, Yufeng, Atkinson, Mark A., Brusko, Maigan, Brusko, Todd M., Yates, Andrew J., Sims, Peter A., and Farber, Donna L.

Published
2023
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3. Immune and epithelial determinants of age-related risk and alveolar injury in fatal COVID-19

Author

Chait, Michael, primary, Yilmaz, Mine M., additional, Shakil, Shanila, additional, Ku, Amy W., additional, Dogra, Pranay, additional, Connors, Thomas J., additional, Szabo, Peter A., additional, Gray, Joshua I., additional, Wells, Steven B., additional, Kubota, Masaru, additional, Matsumoto, Rei, additional, Poon, Maya M.L., additional, Snyder, Mark E., additional, Baldwin, Matthew R., additional, Sims, Peter A., additional, Saqi, Anjali, additional, Farber, Donna L., additional, and Weisberg, Stuart P., additional

Published
2022
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5. TRM and mucosal tissue sites are protected from age-associated phenotypic changes in secondary lymphoid organs

Author

Lam, Nora, primary, Caron, Daniel P, additional, Davis-Porada, Julia, additional, Jensen, Isaac J, additional, Lee, YoonSeung, additional, Morrison-Colvin, Rory, additional, Poon, Maya M.L., additional, Szabo, Peter A, additional, Ural, Basak B, additional, Wells, Steven B, additional, Kubota, Masaru, additional, Matsumoto, Rei, additional, and Farber, Donna L, additional

Published
2022
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6. Persistence of immune memory to SARS-CoV-2 vaccine in lymphoid tissue

Author

Davis-Porada, Julia, primary, Rybkina, Ksenia, additional, Poon, Maya M.L., additional, Caron, Daniel P, additional, Jensen, Isaac J, additional, Kubota, Masaru, additional, Lam, Nora, additional, Lee, Yoon Seung, additional, Matsumoto, Rei, additional, Morrison-Colvin, Rory, additional, Szabo, Peter A, additional, Ural, Basak B, additional, Wells, Steven B, additional, and Farber, Donna L, additional

Published
2022
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7. Human T cells in barrier sites exhibit site-specific characteristics and clonal compartmentalization

Author

Caron, Daniel P, primary, Poon, Maya M.L., additional, Wang, Zicheng, additional, Meng, Wenzhao, additional, Lam, Nora, additional, Szabo, Peter A., additional, Wells, Steven B., additional, Thapa, Puspa, additional, Dogra, Pranay, additional, Lee, Brian, additional, Kubota, Masaru, additional, Matsumoto, Rei, additional, Rahman, Adeeb, additional, Luning Prak, Eline T, additional, Sims, Peter, additional, Shen, Yufeng, additional, and Farber, Donna L, additional

Published
2022
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8. SARS-CoV-2 infection generates tissue-localized immunological memory in humans

Author

Poon, Maya M.L., primary, Rybkina, Ksenia, additional, Kato, Yu, additional, Kubota, Masaru, additional, Matsumoto, Rei, additional, Bloom, Nathaniel I., additional, Zhang, Zeli, additional, Hastie, Kathryn M., additional, Grifoni, Alba, additional, Weiskopf, Daniela, additional, Wells, Steven B., additional, Ural, Basak B., additional, Lam, Nora, additional, Szabo, Peter A., additional, Dogra, Pranay, additional, Lee, Yoon S., additional, Gray, Joshua I., additional, Bradley, Marissa C., additional, Brusko, Maigan A., additional, Brusko, Todd M., additional, Saphire, Erica O., additional, Connors, Thomas J., additional, Sette, Alessandro, additional, Crotty, Shane, additional, and Farber, Donna L., additional

Published
2021
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9. Tissue localization and virus specificity shape the maintenance and function of human virus-specific memory T cells recognizing HCMV and influenza A

Author

Poon, Maya M.L., primary, Byington, Eve, additional, Meng, Wenzhao, additional, Dogra, Pranay, additional, Lam, Nora, additional, Szabo, Peter Anthony, additional, Ural, Basak, additional, Grifoni, Alba, additional, Weiskopf, Daniela, additional, Kubota, Masaru, additional, Matsumoto, Rei, additional, Sette, Alessandro, additional, Shen, Yufeng, additional, Prak, Eline T Luning, additional, and Farber, Donna L, additional

Published
2021
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10. Longitudinal profiling of respiratory and systemic immune responses reveals myeloid cell-driven lung inflammation in severe COVID-19

Author

Szabo, Peter A., primary, Dogra, Pranay, additional, Gray, Joshua I., additional, Wells, Steven B., additional, Connors, Thomas J., additional, Weisberg, Stuart P., additional, Krupska, Izabela, additional, Matsumoto, Rei, additional, Poon, Maya M.L., additional, Idzikowski, Emma, additional, Morris, Sinead E., additional, Pasin, Chloé, additional, Yates, Andrew J., additional, Ku, Amy, additional, Chait, Michael, additional, Davis-Porada, Julia, additional, Guo, Xinzheng V., additional, Zhou, Jing, additional, Steinle, Matthew, additional, Mackay, Sean, additional, Saqi, Anjali, additional, Baldwin, Matthew R., additional, Sims, Peter A., additional, and Farber, Donna L., additional

Published
2021
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12. Heterogeneity of Human Anti-Viral Immunity Shaped by Virus, Tissue, Age, and Sex

Author

Poon, Maya M.L., primary, Byington, Eve, additional, Meng, Wenzhao, additional, Kubota, Masaru, additional, Matsumoto, Rei, additional, Grifoni, Alba, additional, Weiskopf, Daniela, additional, Dogra, Pranay, additional, Lam, Nora, additional, Szabo, Peter A., additional, Ural, Basak Burcu, additional, Wells, Steven B., additional, Rosenfeld, Aaron M., additional, Brusko, Maigan A., additional, Brusko, Todd M., additional, Connors, Thomas J., additional, Sette, Alessandro, additional, Sims, Peter A., additional, Luning Prak, Eline T., additional, Shen, Yufeng, additional, and Farber, Donna, additional

Published
2021
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13. Analysis of respiratory and systemic immune responses in COVID-19 reveals mechanisms of disease pathogenesis

Author

Szabo, Peter A., primary, Dogra, Pranay, additional, Gray, Joshua I., additional, Wells, Steven B., additional, Connors, Thomas J., additional, Weisberg, Stuart P., additional, Krupska, Izabela, additional, Matsumoto, Rei, additional, Poon, Maya M.L., additional, Idzikowski, Emma, additional, Morris, Sinead E., additional, Pasin, Chloé, additional, Yates, Andrew J., additional, Ku, Amy, additional, Chait, Michael, additional, Davis-Porada, Julia, additional, Zhou, Jing, additional, Steinle, Matthew, additional, Mackay, Sean, additional, Saqi, Anjali, additional, Baldwin, Matthew, additional, Sims, Peter A., additional, and Farber, Donna L., additional

Published
2020
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17. Heterogeneity of human anti-viral immunity shaped by virus, tissue, age, and sex.

Author

Poon, Maya M.L., Byington, Eve, Meng, Wenzhao, Kubota, Masaru, Matsumoto, Rei, Grifoni, Alba, Weiskopf, Daniela, Dogra, Pranay, Lam, Nora, Szabo, Peter A., Ural, Basak Burcu, Wells, Steven B., Rosenfeld, Aaron M., Brusko, Maigan A., Brusko, Todd M., Connors, Thomas J., Sette, Alessandro, Sims, Peter A., Luning Prak, Eline T., and Shen, Yufeng

Abstract

The persistence of anti-viral immunity is essential for protection and exhibits profound heterogeneity across individuals. Here, we elucidate the factors that shape maintenance and function of anti-viral T cell immunity in the body by comprehensive profiling of virus-specific T cells across blood, lymphoid organs, and mucosal tissues of organ donors. We use flow cytometry, T cell receptor sequencing, single-cell transcriptomics, and cytokine analysis to profile virus-specific CD8+ T cells recognizing the ubiquitous pathogens influenza and cytomegalovirus. Our results reveal that virus specificity determines overall magnitude, tissue distribution, differentiation, and clonal repertoire of virus-specific T cells. Age and sex influence T cell differentiation and dissemination in tissues, while T cell tissue residence and functionality are highly correlated with the site. Together, our results demonstrate how the covariates of virus, tissue, age, and sex impact the anti-viral immune response, which is important for targeting, monitoring, and predicting immune responses to existing and emerging viruses. [Display omitted] • CD8+ T cells specific for influenza and CMV localize in multiple tissue sites • Persistence of memory CD8+ T cell subsets is shaped by virus tropism and specificity • Regulation of functional responses to viral antigens is primarily tissue mediated • Age and sex influence T cell subset differentiation and tissue residency Through comprehensive cellular and molecular analysis of virus-specific T cells in circulation and across multiple lymphoid and mucosal tissues, Poon et al. elucidate how maintenance and function of the human anti-viral immune response against ubiquitous viruses influenza and cytomegalovirus are shaped by virus, tissue, age, and sex. [ABSTRACT FROM AUTHOR]

Published
2021
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