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Objective: This study aimed to explore whether subclinical hypothyroidism (SCH) treated with levothyroxine in pregnancy complicated by gestational diabetes mellitus (GDM) is associated with an increased risk of gestational hypertensive disorders (GHDs) (gestational hypertension and preeclampsia). Methods: 96 pregnant women with GDM were enrolled in this study and grouped as per the European Thyroid Association criteria into the SCH (n = 21) and euthyroid groups (n = 75). All subjects were tested for anthropometric parameters, maternal glucose homeostasis parameters, lipid levels, thyroid function tests, and blood pressure. All GDM pregnant women received nutritional and insulin therapy where needed, and the SCH group received levothyroxine treatment. Then, the maternal and newborn outcomes were compared. Data were analyzed using Student’s t-test, Mann–Whitney U, and Chi-square tests wherever applicable. p values of p = 0.0004, p = 0.0009). There were no significant differences between groups regarding the incidence of GHD, preterm prelabor rupture of membranes (PPROMs), macrosomia, low birth weight, and fetal distress (p > 0.05). Patients with GDM and SCH treated with levothyroxine had more premature delivery than the euthyroid group (p = 0.03). Conclusions: Subclinical hypothyroidism treated with levothyroxine in women with GDM does not increase the risk of gestational hypertensive disorders, but is associated with increased risk for prematurity.

Background: Gynecological cancers, including ovarian, cervical, and endometrial cancers, significantly affect both survival and reproductive health in women. Cancer treatments such as chemotherapy and radiotherapy can impair ovarian function, reducing oocyte quality and fertility potential. Objective: This review aims to evaluate how vitamins and antioxidants can enhance fertility and fertility preservation outcomes for women diagnosed with gynecological cancers, particularly in the context of assisted reproductive technologies (ART). Standard treatments for these cancers, including hysterectomy, bilateral salpingo-oophorectomy, radiation, and chemotherapy, often compromise ovarian function and oocyte quality. This review focuses on the potential role of these interventions in improving oocyte quality, thereby supporting successful fertility preservation and ART outcomes. Methods: A comprehensive narrative review of the current literature was conducted, examining the effects of vitamins A, C, D3, E, and Coenzyme Q10 on oocyte quality, particularly in the context of oxidative stress and inflammation induced by cancer and its treatments. Results: The evidence suggests that certain vitamins and antioxidants may mitigate oxidative damage and enhance oocyte quality. Vitamin A supports cumulus–oocyte complex integrity, while vitamins C and E act as potent antioxidants, reducing oxidative stress in ovarian tissues. Vitamin D3 enhances ovarian reserve markers and modulates inflammatory cytokines. Coenzyme Q10 improves mitochondrial function and reduces DNA damage, increasing oocyte viability and fertilization potential. Conclusions: The incorporation of specific vitamins and antioxidants into fertility preservation strategies may enhance oocyte quality in women with gynecological cancers. Although the preliminary findings are promising, further research is needed to determine optimal dosages and establish standardized protocols for clinical use. [ABSTRACT FROM AUTHOR]

Objective: This study aimed to explore whether subclinical hypothyroidism (SCH) treated with levothyroxine in pregnancy complicated by gestational diabetes mellitus (GDM) is associated with an increased risk of gestational hypertensive disorders (GHDs) (gestational hypertension and preeclampsia). Methods: 96 pregnant women with GDM were enrolled in this study and grouped as per the European Thyroid Association criteria into the SCH (n = 21) and euthyroid groups (n = 75). All subjects were tested for anthropometric parameters, maternal glucose homeostasis parameters, lipid levels, thyroid function tests, and blood pressure. All GDM pregnant women received nutritional and insulin therapy where needed, and the SCH group received levothyroxine treatment. Then, the maternal and newborn outcomes were compared. Data were analyzed using Student's t-test, Mann–Whitney U, and Chi-square tests wherever applicable. p values of <0.05 were considered significant. Results: Patients with GDM and SCH had a pre-pregnancy BMI and BMI at inclusion in the study smaller than those of the euthyroid group (p = 0.0004, p = 0.0009). There were no significant differences between groups regarding the incidence of GHD, preterm prelabor rupture of membranes (PPROMs), macrosomia, low birth weight, and fetal distress (p > 0.05). Patients with GDM and SCH treated with levothyroxine had more premature delivery than the euthyroid group (p = 0.03). Conclusions: Subclinical hypothyroidism treated with levothyroxine in women with GDM does not increase the risk of gestational hypertensive disorders, but is associated with increased risk for prematurity. [ABSTRACT FROM AUTHOR]

The aerospace industry faces the challenge of maintaining product excellence amidst intricate processes and demands for cost and time efficiency. Mathematical modeling emerges as a valuable tool for optimizing the engineering process and enhancing quality, with potential applications extending beyond aerospace to other sectors with high quality and safety standards. This study develops and validates a mathematical model specific to the aerospace industry, aiming to assess the impact of human resource expertise on product quality. Through a case study within an aerospace organization, an IDEF0-methodology-based mathematical model, coupled with weighted averages, was constructed to depict the comprehensive engineering process and quantify knowledge's impact on deliverable quality. Simulation data, gathered through human resource knowledge assessments and non-conformity analyses, revealed a direct correlation between technical knowledge levels and deliverable quality, consequently impacting final product quality. The proposed model serves as a tool for estimating potential deliverable error rates and pinpointing critical areas within the process that necessitate refinement. The research underscores the significance of knowledge investment and effective knowledge management strategies in upholding quality and competitiveness across industries with stringent quality requirements. [ABSTRACT FROM AUTHOR]

This literature review explores advancements in obesity and diabetes mellitus diagnosis and treatment, highlighting recent innovations that promise more personalized and effective healthcare interventions. For obesity diagnosis, traditional methods like body mass index (BMI) calculations are now complemented by bioelectrical impedance analysis (BIA) and dual-energy X-ray absorptiometry (DXA) scans, with emerging biomarkers from "omics" technologies. Diabetes diagnosis has advanced with standard hemoglobin A1c (HbA1c) testing supplemented by novel measures such as advanced glycation end products (AGEs) and autoantibodies, alongside the use of artificial intelligence to enhance diagnostic accuracy. Treatment options for obesity are expanding beyond traditional methods. Minimally invasive bariatric surgeries, endoscopic procedures, fecal microbiota transplants (FMTs), and pharmaceuticals like GLP-1 receptor agonists (semaglutide, tirzepatide) show promising results. Cognitive behavioral therapy (CBT) and prescription digital therapeutics (PDTs) are also valuable tools for weight management. Diabetes treatment is also undergoing a transformation. Ultra-long-acting insulins and innovative oral insulin delivery methods are on the horizon. SGLT2 inhibitors and GLP-1 receptor agonists are proving to be effective medications for blood sugar control. Continuous glucose monitoring (CGM) systems and closed-loop insulin delivery are revolutionizing diabetes management, while stem cell therapy holds promise for the future. By integrating advanced diagnostic tools with personalized treatment plans, obesity and diabetes care are entering a new era. This personalized approach empowers patients and paves the way for improved health outcomes and a better quality of life. [ABSTRACT FROM AUTHOR]

The present paper highlights a series of introduction aspects of the rotational system for slush plastic casting, which are the characteristic elements of this fabrication technology and which consistsof the rotational molding. Also, the structure of a rotational mold and the methods used to obtain themold, are presented. The purpose of this research is to describe the parametric design of a rotationalmold and its fabrication process. The research method used to accomplish this purpose consist of the CAD – Modelling specific software utilized to carry out the parametric design of the rotational mold. After the parametric design it was adopted the manufacturing technology of the mold, using a CAMspecific software. In the final part of the research a few important conclusions were drawn from the bibliographical study and from personal convictions.

Background: Deep vein thrombosis (DVT) is a dynamic process that can be followed up with Doppler ultrasound (DUS). Aims: To evaluate the role of certain factors that can influence the evolution of DVT. Methods: In 121 DVT patients (mean age 58.19 ± 14.47 years; 30 with no venous thromboembolism (VTE) identifiable risk factors (RF), 31 with weak RF, 30 with moderate RF and 30 with strong RF), DUS was performed at admission and after 1, 3, 6, 12 and 24 months. Favourable evolution was defined as complete resolution of thrombus, whereas unfavourable evolution was defined as incomplete resolution, thrombosis recurrence or post‐thrombotic syndrome. Results: Complete thrombus resolution was found at 1 month (M1) in 24.8% of patients, at 6 months (M6) in 49.6% and at 24 months (M24) in 61.2% of patients. Favourable evolution was seen in younger patients at M1 and M3 (P = 0.004 and P = 0.045) and in cases with earlier treatment (P < 0.0001). In proximal DVT, the risk of non‐favourable evolution was higher (4.05 times at M3, 4.23 times at M6 and 4.29 times at M12). Patients with moderate RF had an earlier favourable evolution (40% at M1, 56.67% at M6 and 70% at M24), and patients with strong RF had the lowest rate of thrombus regression (20% at M1, 36.67% at M6 and 43.33% at M24). Conclusions: DVT evolution can last up to 24 months. Older age, strong VTE RF, proximal DVT localisation and late start of therapy constitute unfavourable evolutive prognosis. These cases need closer clinical and DUS monitoring to prevent complications. [ABSTRACT FROM AUTHOR]

This paper provides an overview of the essential elements in the design and production of aviation components, namely surface treatment, acid pickling, paint adhesion, and Failure Modes and Effects Analysis (FMEA). These factors are critical in ensuring the dependability and safety of aircraft components. Surface treatment is necessary to ensure that paint and coatings adhere to the substrate, while acid pickling is used to treat surfaces and remove impurities, increasing surface roughness. The paper discusses the factors that affect paint adhesion and the procedures used to assess it. FMEA is a systematic approach used in the aerospace industry to identify potential failure modes and evaluate their severity, probability, detectability, and countermeasures. The authors highlight the importance of each of these criteria and emphasize that significant attention must be given to ensure the reliability and safety of aviation components. Careful regulation of acid application is necessary to prevent surface deterioration. Proper preparation of the surface, coating technique, and application circumstances significantly influence paint adhesion. In summary, the aircraft industry places significant emphasis on dependability and quality, and these essential elements must be considered in the design and production of aviation components. [ABSTRACT FROM AUTHOR]