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3. Short-term safety outcomes of mastectomy and immediate implant-based breast reconstruction with and without mesh (iBRA): a multicentre, prospective cohort study

Author

Achuthan, R, Adwan, I, Aggarwal, S, Ahmed, M, Akelund, M, Akolekar, D, Al-Jibury, O, Amanita, M, Appleton, D, Archampong, D, Asgiersson, K, Athwal, R, Augusti, A, Ayaani, S, Bains, S, Baker, B, Baker, E, Baldota, S, Banerjee, D, Barker, S, Barr, L, Barry, P, Basu, N, Bathla, S, Bishop, N, Boland, G, Branford, O A, Bright-Thomas, R, Brindle, R, Brock, L, Brown, V, Bux, F, Byrne, G, Cain, H, Caldon, L, Callaghan, M, Carbone, A, Carpenter, R, Cawthorn, S, Chagla, L, Challoner, T, Chalmers, C, Chalmers, R, Chambers, S, Chana, M, Chand, N, Chandran, V, Chandrashekar, M, Charfare, H, Chatterjee, J, Chatterjee, S, Chattopadhyay, R, Chaudry, A, Chin, K, Chong, K, Chouhan, A, Choy, C, Christopoulos, P, Clarke, D, Clarke, S, Clayton, E, Clifford, R, Cocker, D, Collin, T, Collis, N, Conroy, F, Constantinou, C, Conway, A, Cook, J, Coombs, N, Cox, K, Critchley, A, Dakka, M, Dani, M, Daoud, R, Darragh, L, Darvesh, S, Dash, I, Datta, S, Davies, E, Dawson, S, De Sousa, E, Debnath, D, Deol, H, Devalia, H, Di Micco, R, Dicks, JR, Dickson, J, Dobner, N, Dobson, G, Dunne, N, Egbeare, D, El Sharief, D, Elfadl, D, Eltigani, E, Enver, D, Erel, E, Evans, A, Exarchos, G, Fage, E, Fatayer, H, Fenn, C, Ferguson, D, Foulkes, R, Franks, J, Fung, V, Galea, M, Gandamihardja, T, Gandhi, A, Garnsey, C, Gateley, C, Gattuso, J, Gawne, S, Geerthan, N, Ghattura, A, Giaramadze, A, Gill, J, Godden, AR, Goh, S, Govindarajulu, S, Goyal, S, Graja, T, Granger, S, Green, M, Grover, K, Gui, G, Gurung, R, Gutteridge, E, Hakim, A, Halka, A, Hamilton-Burke, W, Hamo, I, Harding-Mackean, C, Hargreaves, A, Harries, S, Harris, K, Harris, P, Harrison, S, Harvey, J, Hashem, M, Hassan, U, Henderson, J, Henton, J, Hignett, S, Hodgkins, K, Horgan, K, Horn, S, Hu, J, Hussain, A, Iddon, J, Iqbal, A, Irri, R, Irvine, T, Irwin, G, Iskender, A, Ismail, A, Ives, C, James, K, James, R, Jiwa, N, Jobson, M, Joglekar, S, Johnson, L, Johnson, R, Jones, L, Ju Hwang, M, Kalles, V, Kanesalingam, K, Karat, I, Kaushik, M, Kennedy, K, Khalifa, E, Khan, H, Khanbhai, M, Khawaja, S, Khout, H, Kiernan, T, Kim, B, Kirkpatrick, K, Kiruparan, P, Kirwan, C, Kishore, M, Kneeshaw, P, Knight, A, Kohlhardt, S, Krupa, J, Krupa, K, Kuruvilla, R, Laban, C, Lai, LM, Laidlaw, I, Lambert, K, Langlands, F, Lansdown, M, Laurence, N, Laws, S, Ledwidge, S, Lefemine, V, Lennon, H, Linforth, R, Little, K, Luangsomboon, A, Lund, J, Maalo, J, MacLennan, L, Macmillan, RD, MacNeil, F, Mahapatra, TK, Mallidis, E, Mallon, P, Manoloudakis, N, Maraqa, L, Marla, S, Masood, S, Massey, J, Masudi, T, Matey, P, Mazari, F, McCulley, S, McEvoy, K, Mcintosh, J, McIntosh, S, McKenzie, S, McManus, P, McNicholas, J, Michalakis, I, Mills, N, Mitchell, G, Monib, S, Mullan, M, Murphy, C, Murphy, G, Murphy, J, Murthy, B, Musa, S, Nagra, G, Nangalia, R, Narayanan, S, Nasr, R, Navin, C, Newton, R, Nicholson, S, Nuru, N, O'Connell, R, O'Donoghue, J, Ogedegbe, A, Olayinka, OS, Olsen, S, Osborn, G, Osborne, C, Osman, H, Otieno, C, Pakzad, F, Park, A, Parker, S, Partlett, P, Parvaiz, A, Parvanta, L, Patel, G, Peel, A, Peiris, L, Pennick, M, Peppe, A, Perry, D, Pilgrim, S, Piper, J, Poonawalla, S, Popa, E, Pope, V, Pugh, P, Rainsbury, D, Ramsey, K, Rasheed, T, Rathinaezhil, R, Rattay, T, Ravichandran, D, Reed, M, Refsum, S, Remoundos, D, Rigby, K, Robertson, S, Robinson, A, Robinson, J, Roche, N, Roy, PJ, Runkel, M, Rusby, J, Saha, S, Saidan, Z, Salab, M, Saleh, M, Salem, F, Sami, A, Samlalsingh, S, Sarfraz, N, Shah, R, Shaheed, S, Sharaiha, Y, Shetty, G, Shotton, R, Sircar, T, Skene, E, Sloan, S, Smith, B, Smith, J, Soldanova, L, Soliman, F, Soumian, S, Stevens, J, Steventon, C, Stewart-Parker, E, Stringfellow, T, Sutaria, R, Sutton, R, Sweetland, H, Swiech, B, Tadiparthi, S, Tafazal, H, Taheri, N, Tait, C, Tan, M, Tang, S, Tansley, A, Tate, S, Tayeh, S, Taylor, A, Taylor, J, Thawdar, P, Thomas, C, Thomas, S, Thomson, S, Thorne, A, Tillett, R, Tolkien, Z, Tomlins, A, Topps, A, Tsang, F, Turner, EJ, Turton, P, Udayasankar, S, Ugolini, F, Vaughan Williams, E, Vidya, R, Vijaynagar, B, Vinayagam, R, Volleamere, A, Voynov, V, Waheed, S, Walker, T, Walsh, U, Warner, R, Waters, R, Wilkins, A, Williams, K, Wilson, G, Wiltsher, M, Wooler, B, Wright, C, Wright, M, Wyld, L, Youssef, M, Zabkiewicz, C, Zammit, C, Zeidan, B, Zheng, D, Potter, Shelley, Conroy, Elizabeth J, Cutress, Ramsey I, Williamson, Paula R, Whisker, Lisa, Thrush, Steven, Skillman, Joanna, Barnes, Nicola L P, Mylvaganam, Senthurun, Teasdale, Elisabeth, Jain, Abhilash, Gardiner, Matthew D, Blazeby, Jane M, and Holcombe, Chris

Published
2019
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6. IMAGING FINDINGS AND MANAGEMENT OF KIDNEY CYSTS - A PICTORIAL ESSAY.

Author

COROIU, R. E., POPA, R. M., POPA, E. M., HOGEA, A. C., MANEA, R. M., and SCÂRNECIU, I.

Subjects
CYSTIC kidney disease, ASYMPTOMATIC patients, DENTIGEROUS cyst, DIFFERENTIAL diagnosis
Abstract

Renal cysts have become more commonly recognized in asymptomatic patients due to the improvement and frequency of the use of advanced imaging modalities, such as CT and MRI. The purpose of the following review is to illustrate the main and most important aspects of renal cysts, including a checklist of top differential diagnoses and also, their further management and treatment options. Some renal cysts can have significant clinical implications; this is why increased awareness of these renal lesions is of the utmost importance in order to avoid diagnostic pitfalls or further complications. [ABSTRACT FROM AUTHOR]

Published
2023
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8. Large Methane Emissions From the Pantanal During Rising Water‐Levels Revealed by Regularly Measured Lower Troposphere CH₄ Profiles

Author

Gloor, M, Gatti, LV, Wilson, C, Parker, RJ, Boesch, H, Popa, E, Chipperfield, MP, Poulter, B, Zhang, Z, Basso, L, Miller, J, McNorton, J, Jimenez, C, and Prigent, C

Abstract

The Pantanal region of Brazil is the largest seasonally flooded tropical grassland and, according to local chamber measurements, a substantial CH4 source. CH4 emissions from wetlands have recently become of heightened interest because global atmospheric 13CH4 data indicate they may contribute to the resumption of atmospheric CH4 growth since 2007. We have regularly measured vertical atmospheric profiles for 2 years in the center of the Pantanal with the objectives to obtain an estimate of CH4 emissions using an atmospheric approach, and provide information about flux seasonality and its relation to controlling factors. Boundary layer-free troposphere differences observed in the Pantanal are large compared to other wetlands. Total emissions based on a planetary boundary layer budgeting technique are 2.0–2.8 TgCH4 yr−1 (maximum flux ∼0.4 gCH4 m−2 d−1) while those based on a Bayesian inversion using an atmospheric transport model are ∼3.3 TgCH4 yr−1. Compared to recent estimates for Amazonia (∼41 ± 3 TgCH4 yr−1, maximum flux ∼0.3 gCH4 m−2 d−1) these emissions are not that large. Our Pantanal data suggest a clear flux seasonality with CH4 being released in large amounts just after water levels begin to rise again after minimum levels have been reached. CH4 emissions decline substantially once the maximum water level has been reached. While predictions with prognostic wetland CH4 emission models agree well with the magnitude of the fluxes, they disagree with the phasing. Our approach shows promise for detecting and understanding longer-term trends in CH4 emissions and the potential for future wetlands CH4 emissions climate feedbacks.

Published
2021

9. Large Methane Emissions From the Pantanal During Rising Water-Levels Revealed by Regularly Measured Lower Troposphere CH4 Profiles

Author

Gloor, M., Gatti, L. V., Wilson, C., Parker, R. J., Boesch, H., Popa, E., Chipperfield, M. P., Poulter, B., Zhang, Z., Basso, L., Miller, J., McNorton, J., Jimenez, C., Prigent, C., Afd Marine and Atmospheric Research, Sub Atmospheric physics and chemistry, Marine and Atmospheric Research, and Nanophotonics

Subjects
Global and Planetary Change, Atmospheric Science, seasonally flooded savannah, Environmental Science(all), Taverne, climate feedback, Environmental Chemistry, Pantanal, atmospheric methane, wetlands
Abstract

The Pantanal region of Brazil is the largest seasonally flooded tropical grassland and, according to local chamber measurements, a substantial CH4 source. CH4 emissions from wetlands have recently become of heightened interest because global atmospheric 13CH4 data indicate they may contribute to the resumption of atmospheric CH4 growth since 2007. We have regularly measured vertical atmospheric profiles for 2 years in the center of the Pantanal with the objectives to obtain an estimate of CH4 emissions using an atmospheric approach, and provide information about flux seasonality and its relation to controlling factors. Boundary layer-free troposphere differences observed in the Pantanal are large compared to other wetlands. Total emissions based on a planetary boundary layer budgeting technique are 2.0–2.8 TgCH4 yr−1 (maximum flux ∼0.4 gCH4 m−2 d−1) while those based on a Bayesian inversion using an atmospheric transport model are ∼3.3 TgCH4 yr−1. Compared to recent estimates for Amazonia (∼41 ± 3 TgCH4 yr−1, maximum flux ∼0.3 gCH4 m−2 d−1) these emissions are not that large. Our Pantanal data suggest a clear flux seasonality with CH4 being released in large amounts just after water levels begin to rise again after minimum levels have been reached. CH4 emissions decline substantially once the maximum water level has been reached. While predictions with prognostic wetland CH4 emission models agree well with the magnitude of the fluxes, they disagree with the phasing. Our approach shows promise for detecting and understanding longer-term trends in CH4 emissions and the potential for future wetlands CH4 emissions climate feedbacks.

Published
2021

11. Large Methane Emissions From the Pantanal During Rising Water‐Levels Revealed by Regularly Measured Lower Troposphere CH 4 Profiles

Author

Gloor, M., primary, Gatti, L. V., additional, Wilson, C., additional, Parker, R. J., additional, Boesch, H., additional, Popa, E., additional, Chipperfield, M. P., additional, Poulter, B., additional, Zhang, Z., additional, Basso, L., additional, Miller, J., additional, McNorton, J., additional, Jimenez, C., additional, and Prigent, C., additional

Published
2021
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12. 84TiP Predictive value of exosomes for therapy response in resectable/borderline resectable pancreatic cancer patients

Author

Cazacu, I.M., primary, Croitoru, V.M., additional, Paul, D., additional, Popa, E., additional, Matei, I., additional, Gheorghe, C., additional, Herlea, V., additional, Diculescu, M., additional, Bogdan, D., additional, Sandra, I., additional, Gramaticu, I-M., additional, Luca, N.I., additional, Dinu, I.M., additional, Alexandrescu, S., additional, Sorop, A., additional, Croitoru, A.E., additional, Dima, S., additional, Popescu, I., additional, and Lyden, D., additional

Published
2021
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13. Large Methane Emissions From the Pantanal During Rising Water-Levels Revealed by Regularly Measured Lower Troposphere CH4 Profiles

Author

Afd Marine and Atmospheric Research, Sub Atmospheric physics and chemistry, Marine and Atmospheric Research, Nanophotonics, Gloor, M., Gatti, L. V., Wilson, C., Parker, R. J., Boesch, H., Popa, E., Chipperfield, M. P., Poulter, B., Zhang, Z., Basso, L., Miller, J., McNorton, J., Jimenez, C., Prigent, C., Afd Marine and Atmospheric Research, Sub Atmospheric physics and chemistry, Marine and Atmospheric Research, Nanophotonics, Gloor, M., Gatti, L. V., Wilson, C., Parker, R. J., Boesch, H., Popa, E., Chipperfield, M. P., Poulter, B., Zhang, Z., Basso, L., Miller, J., McNorton, J., Jimenez, C., and Prigent, C.

Published
2021

15. EDIBLE COATING FOR FUNCTIONALITY IMPROVEMENT OF MINIMALLY PROCESSED ORGANIC APPLES.

Author

POPA, E. E., POPESCU, P. A., MITELUȚ, A. C., DRĂGHICI, M. C., GEICU-CRISTEA, M., and POPA, M. E.

Subjects
EDIBLE coatings, PRESERVATION of fruit, FRUIT quality, WHOLE grain foods, HARVESTING, MARKETING, ORCHARDS
Abstract

Consumer interest in purchasing safe, nutritious, minimally processed, and healthy foods has led to increased consumption of various fruits and vegetables. In general, fruit quality depends on nutritional, microbiological and organoleptic properties, all of which are exposed to dynamic changes during harvesting, minimally processing, storage and marketing. These changes occur mainly due to the interactions between the fruit and the environment or the migration between the different internal components, which can lead to the loss of moisture and some volatile compounds. Therefore, an emerging need for quality preservation of fruits arise in the last years; the technique of edible coatings being a good alternative to control some of these factors, involving thin layers of edible materials formed directly on the surface of foods that can be consumed as part of the whole product. The purpose of the present study was to develop an edible coating based on pectin, with the addition of a functional organic seabuckthorn extract obtained by ultrasound assisted extraction, to improve organic apple cubes quality. The results of this study showed that the developed edible coating improved apple functionality, increasing the antioxidant activity and polyphenolic content of the coated apples. [ABSTRACT FROM AUTHOR]

Published
2022

16. CONSUMER PERCEPTIONS OF FUNCTIONAL FOODS FOR TYPE 2 DIABETES IN ROMANIA AND REPUBLIC OF MOLDOVA.

Author

SERGHEEVA, E., GEICU-CRISTEA, M., MATEI, F., POPA, M. E., JADEJA, R., POPA, E. E., ROBU, E., and POPOVICI, C.

Subjects
TYPE 2 diabetes, FUNCTIONAL foods, CONSUMERS, SUPPLY & demand
Abstract

In the frame of the study, the perception by consumers of functional foods for people with type 2 diabetes, the factors of consumer perception of foods, the principles of their choice of functional foods were studied. The 2 online questionnaires were developed to conduct a survey in 2 countries - Republic of Moldova and Romania; the analysis of the obtained data and their comparison with each other was carried out. On the basis of obtained data, the important conclusions were made that contribute to the prevention of the problem of low demand for functional foods for people with type 2 diabetes. [ABSTRACT FROM AUTHOR]

Published
2022

28. Large Methane Emissions From the Pantanal During Rising Water‐Levels Revealed by Regularly Measured Lower Troposphere CH4 Profiles.

Author

Gloor, M., Gatti, L. V., Wilson, C., Parker, R. J., Boesch, H., Popa, E., Chipperfield, M. P., Poulter, B., Zhang, Z., Basso, L., Miller, J., McNorton, J., Jimenez, C., and Prigent, C.

Subjects
ATMOSPHERIC boundary layer, SWAMPS, CLIMATE feedbacks, TROPOSPHERE, ATMOSPHERIC transport, GRASSLANDS
Abstract

The Pantanal region of Brazil is the largest seasonally flooded tropical grassland and, according to local chamber measurements, a substantial CH4 source. CH4 emissions from wetlands have recently become of heightened interest because global atmospheric 13CH4 data indicate they may contribute to the resumption of atmospheric CH4 growth since 2007. We have regularly measured vertical atmospheric profiles for 2 years in the center of the Pantanal with the objectives to obtain an estimate of CH4 emissions using an atmospheric approach, and provide information about flux seasonality and its relation to controlling factors. Boundary layer‐free troposphere differences observed in the Pantanal are large compared to other wetlands. Total emissions based on a planetary boundary layer budgeting technique are 2.0–2.8 TgCH4 yr−1 (maximum flux ∼0.4 gCH4 m−2 d−1) while those based on a Bayesian inversion using an atmospheric transport model are ∼3.3 TgCH4 yr−1. Compared to recent estimates for Amazonia (∼41 ± 3 TgCH4 yr−1, maximum flux ∼0.3 gCH4 m−2 d−1) these emissions are not that large. Our Pantanal data suggest a clear flux seasonality with CH4 being released in large amounts just after water levels begin to rise again after minimum levels have been reached. CH4 emissions decline substantially once the maximum water level has been reached. While predictions with prognostic wetland CH4 emission models agree well with the magnitude of the fluxes, they disagree with the phasing. Our approach shows promise for detecting and understanding longer‐term trends in CH4 emissions and the potential for future wetlands CH4 emissions climate feedbacks. Plain Language Summary: CH4 emissions contribute substantially to greenhouse warming and atmospheric concentrations continue to grow rapidly. Increases in emissions from wetlands may contribute. We have measured regularly vertical CH4 concentration profiles over the Pantanal, the largest tropical seasonally flooded grasslands, to provide an estimate of these emissions and to determine seasonal cycle. Our estimates are similar to earlier estimates based on direct flux measurements on the ground. Fluxes vary strongly seasonally. They are largest during the rise of water levels and decrease before maximum levels have been reached. Our data show that longer‐term vertical profile measurements could provide an answer whether wetland emissions are changing. Key Points: Large CH4 boundary layer‐free troposphere differences over Pantanal wetlands revealed by vertical atmospheric CH4 profile dataAccording to atmospheric data, CH4 flux is large during the early expansion phase of the inundated area and weakens at peak extentPrognostic global wetlands CH4 emission models have limited skill regarding seasonality of Pantanal emissions [ABSTRACT FROM AUTHOR]

Published
2021
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29. Pembrolizumab alone or with chemotherapy versus cetuximab with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-048): a randomised, open-label, phase 3 study

Author

Burtness, B. Harrington, K.J. Greil, R. Soulières, D. Tahara, M. de Castro, G., Jr Psyrri, A. Basté, N. Neupane, P. Bratland, Å. Fuereder, T. Hughes, B.G.M. Mesía, R. Ngamphaiboon, N. Rordorf, T. Wan Ishak, W.Z. Hong, R.-L. González Mendoza, R. Roy, A. Zhang, Y. Gumuscu, B. Cheng, J.D. Jin, F. Rischin, D. Lerzo, G. Tatangelo, M. Varela, M. Zarba, J.J. Boyer, M. Gan, H. Gao, B. Hughes, B. Mallesara, G. Taylor, A. Burian, M. Barrios, C.H. de Castro Junior, D.O. Castro, G. Franke, F.A. Girotto, G. Lima, I.P.F. Nicolau, U.R. Pinto, G.D.J. Santos, L. Victorino, A.-P. Chua, N. Couture, F. Gregg, R. Hansen, A. Hilton, J. McCarthy, J. Soulieres, D. Ascui, R. Gonzalez, P. Villanueva, L. Torregroza, M. Zambrano, A. Holeckova, P. Kral, Z. Melichar, B. Prausova, J. Vosmik, M. Andersen, M. Gyldenkerne, N. Jurgens, H. Putnik, K. Reinikainen, P. Gruenwald, V. Laban, S. Aravantinos, G. Boukovinas, I. Georgoulias, V. Kwong, D. Al-Farhat, Y. Csoszi, T. Erfan, J. Horvai, G. Landherr, L. Remenar, E. Ruzsa, A. Szota, J. Billan, S. Gluck, I. Gutfeld, O. Popovtzer, A. Benasso, M. Bui, S. Ferrari, V. Licitra, L. Nole, F. Fujii, T. Fujimoto, Y. Hanai, N. Hara, H. Matsumoto, K. Mitsugi, K. Monden, N. Nakayama, M. Okami, K. Oridate, N. Shiga, K. Shimizu, Y. Sugasawa, M. Takahashi, M. Takahashi, S. Tanaka, K. Ueda, T. Yamaguchi, H. Yamazaki, T. Yasumatsu, R. Yokota, T. Yoshizaki, T. Kudaba, I. Stara, Z. Cheah, S.K. Aguilar Ponce, J. Gonzalez Mendoza, R. Hernandez Hernandez, C. Medina Soto, F. Buter, J. Hoeben, A. Oosting, S. Suijkerbuijk, K. Bratland, A. Brydoey, M. Alvarez, R. Mas, L. Caguioa, P. Querol, J. Regala, E.E. Tamayo, M.B. Villegas, E.M. Kawecki, A. Karpenko, A. Klochikhin, A. Smolin, A. Zarubenkov, O. Goh, B.C. Cohen, G. du Toit, J. Jordaan, C. Landers, G. Ruff, P. Szpak, W. Tabane, N. Brana, I. Iglesias Docampo, L. Lavernia, J. Mesia, R. Abel, E. Muratidu, V. Nielsen, N. Cristina, V. Rothschild, S. Wang, H.-M. Yang, M.-H. Yeh, S.-P. Yen, C.-J. Soparattanapaisarn, N. Sriuranpong, V. Aksoy, S. Cicin, I. Ekenel, M. Harputluoglu, H. Ozyilkan, O. Agarwala, S. Ali, H. Alter, R. Anderson, D. Bruce, J. Campbell, N. Conde, M. Deeken, J. Edenfield, W. Feldman, L. Gaughan, E. Goueli, B. Halmos, B. Hegde, U. Hunis, B. Jotte, R. Karnad, A. Khan, S. Laudi, N. Laux, D. Martincic, D. McCune, S. McGaughey, D. Misiukiewicz, K. Mulford, D. Nadler, E. Nunnink, J. Ohr, J. O'Malley, M. Patson, B. Paul, D. Popa, E. Powell, S. Redman, R. Rella, V. Rocha Lima, C. Sivapiragasam, A. Su, Y. Sukari, A. Wong, S. Yilmaz, E. Yorio, J.

Abstract

Background: Pembrolizumab is active in head and neck squamous cell carcinoma (HNSCC), with programmed cell death ligand 1 (PD-L1) expression associated with improved response. Methods: KEYNOTE-048 was a randomised, phase 3 study of participants with untreated locally incurable recurrent or metastatic HNSCC done at 200 sites in 37 countries. Participants were stratified by PD-L1 expression, p16 status, and performance status and randomly allocated (1:1:1) to pembrolizumab alone, pembrolizumab plus a platinum and 5-fluorouracil (pembrolizumab with chemotherapy), or cetuximab plus a platinum and 5-fluorouracil (cetuximab with chemotherapy). Investigators and participants were aware of treatment assignment. Investigators, participants, and representatives of the sponsor were masked to the PD-L1 combined positive score (CPS) results; PD-L1 positivity was not required for study entry. The primary endpoints were overall survival (time from randomisation to death from any cause) and progression-free survival (time from randomisation to radiographically confirmed disease progression or death from any cause, whichever came first) in the intention-to-treat population (all participants randomly allocated to a treatment group). There were 14 primary hypotheses: superiority of pembrolizumab alone and of pembrolizumab with chemotherapy versus cetuximab with chemotherapy for overall survival and progression-free survival in the PD-L1 CPS of 20 or more, CPS of 1 or more, and total populations and non-inferiority (non-inferiority margin: 1·2) of pembrolizumab alone and pembrolizumab with chemotherapy versus cetuximab with chemotherapy for overall survival in the total population. The definitive findings for each hypothesis were obtained when statistical testing was completed for that hypothesis; this occurred at the second interim analysis for 11 hypotheses and at final analysis for three hypotheses. Safety was assessed in the as-treated population (all participants who received at least one dose of allocated treatment). This study is registered at ClinicalTrials.gov, number NCT02358031. Findings: Between April 20, 2015, and Jan 17, 2017, 882 participants were allocated to receive pembrolizumab alone (n=301), pembrolizumab with chemotherapy (n=281), or cetuximab with chemotherapy (n=300); of these, 754 (85%) had CPS of 1 or more and 381 (43%) had CPS of 20 or more. At the second interim analysis, pembrolizumab alone improved overall survival versus cetuximab with chemotherapy in the CPS of 20 or more population (median 14·9 months vs 10·7 months, hazard ratio [HR] 0·61 [95% CI 0·45–0·83], p=0·0007) and CPS of 1 or more population (12·3 vs 10·3, 0·78 [0·64–0·96], p=0·0086) and was non-inferior in the total population (11·6 vs 10·7, 0·85 [0·71–1·03]). Pembrolizumab with chemotherapy improved overall survival versus cetuximab with chemotherapy in the total population (13·0 months vs 10·7 months, HR 0·77 [95% CI 0·63–0·93], p=0·0034) at the second interim analysis and in the CPS of 20 or more population (14·7 vs 11·0, 0·60 [0·45–0·82], p=0·0004) and CPS of 1 or more population (13·6 vs 10·4, 0·65 [0·53–0·80], p

Published
2019

30. Green Wedge. Wendingen in de dialoog over duurzame energietechnologie. Eindrapport en workshopformasat

Author

Dreijerink, L.J.M., Handgraaf, M., Akker, F. van den, Popa, E., and Koeslag, M.

Subjects
Energy, Energy Efficiency, Energy / Geological Survey Netherlands
Abstract

Aanleiding en doel van het Green Wedge project Terwijl de techniek voorhanden is en er geen economische barrières zijn, is er in de industrie sprake van een onderbenut potentieel van energie efficiëntie. ISPT spreekt dagelijks met technologieontwikkelaars, aanbieders en adviseurs over nieuwe technologieën die, als ze worden toegepast, het energieverbruik omlaag kunnen brengen. Het blijkt dat deze partijen het lastig vinden om de duurzame waarde van de oplossing bij potentiële klanten onder de aandacht te brengen. Vooral technologieleveranciers in het MKB geven aan hierbij hulp nodig te hebben. Er wordt nu grotendeels geconcurreerd op prijs en productspecificaties, maar energie efficiënte oplossingen zijn meestal wat duurder dan de standaardoplossing en brengen een zeker risico met zich mee voor de koper. In dit project wilden we duurzame technologieleveranciers handvatten bieden om hun product of dienst op andere aspecten dan op prijs en techniek te presenteren. Het Green Wedge project was gericht het ontwikkelen van een workshop format voor duurzame technologieleveranciers uit het MKB. De belofte van het format was: U leert een duurzame propositie zodanig voor het voetlicht te brengen bij bestaande en mogelijke klanten dat dit de klant-leverancier relatie positief beïnvloedt. Wij menen een format ontwikkeld te hebben dat geschikt is voor dit doel.

Published
2019

35. Short-term safety outcomes of mastectomy and immediate implant-based breast reconstruction with and without mesh (iBRA): a multicentre, prospective cohort study

Author

Potter, Shelley, primary, Conroy, Elizabeth J, additional, Cutress, Ramsey I, additional, Williamson, Paula R, additional, Whisker, Lisa, additional, Thrush, Steven, additional, Skillman, Joanna, additional, Barnes, Nicola L P, additional, Mylvaganam, Senthurun, additional, Teasdale, Elisabeth, additional, Jain, Abhilash, additional, Gardiner, Matthew D, additional, Blazeby, Jane M, additional, Holcombe, Chris, additional, Achuthan, R, additional, Adwan, I, additional, Aggarwal, S, additional, Ahmed, M, additional, Akelund, M, additional, Akolekar, D, additional, Al-Jibury, O, additional, Amanita, M, additional, Appleton, D, additional, Archampong, D, additional, Asgiersson, K, additional, Athwal, R, additional, Augusti, A, additional, Ayaani, S, additional, Bains, S, additional, Baker, B, additional, Baker, E, additional, Baldota, S, additional, Banerjee, D, additional, Barker, S, additional, Barr, L, additional, Barry, P, additional, Basu, N, additional, Bathla, S, additional, Bishop, N, additional, Boland, G, additional, Branford, O A, additional, Bright-Thomas, R, additional, Brindle, R, additional, Brock, L, additional, Brown, V, additional, Bux, F, additional, Byrne, G, additional, Cain, H, additional, Caldon, L, additional, Callaghan, M, additional, Carbone, A, additional, Carpenter, R, additional, Cawthorn, S, additional, Chagla, L, additional, Challoner, T, additional, Chalmers, C, additional, Chalmers, R, additional, Chambers, S, additional, Chana, M, additional, Chand, N, additional, Chandran, V, additional, Chandrashekar, M, additional, Charfare, H, additional, Chatterjee, J, additional, Chatterjee, S, additional, Chattopadhyay, R, additional, Chaudry, A, additional, Chin, K, additional, Chong, K, additional, Chouhan, A, additional, Choy, C, additional, Christopoulos, P, additional, Clarke, D, additional, Clarke, S, additional, Clayton, E, additional, Clifford, R, additional, Cocker, D, additional, Collin, T, additional, Collis, N, additional, Conroy, F, additional, Constantinou, C, additional, Conway, A, additional, Cook, J, additional, Coombs, N, additional, Cox, K, additional, Critchley, A, additional, Dakka, M, additional, Dani, M, additional, Daoud, R, additional, Darragh, L, additional, Darvesh, S, additional, Dash, I, additional, Datta, S, additional, Davies, E, additional, Dawson, S, additional, De Sousa, E, additional, Debnath, D, additional, Deol, H, additional, Devalia, H, additional, Di Micco, R, additional, Dicks, JR, additional, Dickson, J, additional, Dobner, N, additional, Dobson, G, additional, Dunne, N, additional, Egbeare, D, additional, El Sharief, D, additional, Elfadl, D, additional, Eltigani, E, additional, Enver, D, additional, Erel, E, additional, Evans, A, additional, Exarchos, G, additional, Fage, E, additional, Fatayer, H, additional, Fenn, C, additional, Ferguson, D, additional, Foulkes, R, additional, Franks, J, additional, Fung, V, additional, Galea, M, additional, Gandamihardja, T, additional, Gandhi, A, additional, Garnsey, C, additional, Gateley, C, additional, Gattuso, J, additional, Gawne, S, additional, Geerthan, N, additional, Ghattura, A, additional, Giaramadze, A, additional, Gill, J, additional, Godden, AR, additional, Goh, S, additional, Govindarajulu, S, additional, Goyal, S, additional, Graja, T, additional, Granger, S, additional, Green, M, additional, Grover, K, additional, Gui, G, additional, Gurung, R, additional, Gutteridge, E, additional, Hakim, A, additional, Halka, A, additional, Hamilton-Burke, W, additional, Hamo, I, additional, Harding-Mackean, C, additional, Hargreaves, A, additional, Harries, S, additional, Harris, K, additional, Harris, P, additional, Harrison, S, additional, Harvey, J, additional, Hashem, M, additional, Hassan, U, additional, Henderson, J, additional, Henton, J, additional, Hignett, S, additional, Hodgkins, K, additional, Horgan, K, additional, Horn, S, additional, Hu, J, additional, Hussain, A, additional, Iddon, J, additional, Iqbal, A, additional, Irri, R, additional, Irvine, T, additional, Irwin, G, additional, Iskender, A, additional, Ismail, A, additional, Ives, C, additional, James, K, additional, James, R, additional, Jiwa, N, additional, Jobson, M, additional, Joglekar, S, additional, Johnson, L, additional, Johnson, R, additional, Jones, L, additional, Ju Hwang, M, additional, Kalles, V, additional, Kanesalingam, K, additional, Karat, I, additional, Kaushik, M, additional, Kennedy, K, additional, Khalifa, E, additional, Khan, H, additional, Khanbhai, M, additional, Khawaja, S, additional, Khout, H, additional, Kiernan, T, additional, Kim, B, additional, Kirkpatrick, K, additional, Kiruparan, P, additional, Kirwan, C, additional, Kishore, M, additional, Kneeshaw, P, additional, Knight, A, additional, Kohlhardt, S, additional, Krupa, J, additional, Krupa, K, additional, Kuruvilla, R, additional, Laban, C, additional, Lai, LM, additional, Laidlaw, I, additional, Lambert, K, additional, Langlands, F, additional, Lansdown, M, additional, Laurence, N, additional, Laws, S, additional, Ledwidge, S, additional, Lefemine, V, additional, Lennon, H, additional, Linforth, R, additional, Little, K, additional, Luangsomboon, A, additional, Lund, J, additional, Maalo, J, additional, MacLennan, L, additional, Macmillan, RD, additional, MacNeil, F, additional, Mahapatra, TK, additional, Mallidis, E, additional, Mallon, P, additional, Manoloudakis, N, additional, Maraqa, L, additional, Marla, S, additional, Masood, S, additional, Massey, J, additional, Masudi, T, additional, Matey, P, additional, Mazari, F, additional, McCulley, S, additional, McEvoy, K, additional, Mcintosh, J, additional, McIntosh, S, additional, McKenzie, S, additional, McManus, P, additional, McNicholas, J, additional, Michalakis, I, additional, Mills, N, additional, Mitchell, G, additional, Monib, S, additional, Mullan, M, additional, Murphy, C, additional, Murphy, G, additional, Murphy, J, additional, Murthy, B, additional, Musa, S, additional, Nagra, G, additional, Nangalia, R, additional, Narayanan, S, additional, Nasr, R, additional, Navin, C, additional, Newton, R, additional, Nicholson, S, additional, Nuru, N, additional, O'Connell, R, additional, O'Donoghue, J, additional, Ogedegbe, A, additional, Olayinka, OS, additional, Olsen, S, additional, Osborn, G, additional, Osborne, C, additional, Osman, H, additional, Otieno, C, additional, Pakzad, F, additional, Park, A, additional, Parker, S, additional, Partlett, P, additional, Parvaiz, A, additional, Parvanta, L, additional, Patel, G, additional, Peel, A, additional, Peiris, L, additional, Pennick, M, additional, Peppe, A, additional, Perry, D, additional, Pilgrim, S, additional, Piper, J, additional, Poonawalla, S, additional, Popa, E, additional, Pope, V, additional, Pugh, P, additional, Rainsbury, D, additional, Ramsey, K, additional, Rasheed, T, additional, Rathinaezhil, R, additional, Rattay, T, additional, Ravichandran, D, additional, Reed, M, additional, Refsum, S, additional, Remoundos, D, additional, Rigby, K, additional, Robertson, S, additional, Robinson, A, additional, Robinson, J, additional, Roche, N, additional, Roy, PJ, additional, Runkel, M, additional, Rusby, J, additional, Saha, S, additional, Saidan, Z, additional, Salab, M, additional, Saleh, M, additional, Salem, F, additional, Sami, A, additional, Samlalsingh, S, additional, Sarfraz, N, additional, Shah, R, additional, Shaheed, S, additional, Sharaiha, Y, additional, Shetty, G, additional, Shotton, R, additional, Sircar, T, additional, Skene, E, additional, Sloan, S, additional, Smith, B, additional, Smith, J, additional, Soldanova, L, additional, Soliman, F, additional, Soumian, S, additional, Stevens, J, additional, Steventon, C, additional, Stewart-Parker, E, additional, Stringfellow, T, additional, Sutaria, R, additional, Sutton, R, additional, Sweetland, H, additional, Swiech, B, additional, Tadiparthi, S, additional, Tafazal, H, additional, Taheri, N, additional, Tait, C, additional, Tan, M, additional, Tang, S, additional, Tansley, A, additional, Tate, S, additional, Tayeh, S, additional, Taylor, A, additional, Taylor, J, additional, Thawdar, P, additional, Thomas, C, additional, Thomas, S, additional, Thomson, S, additional, Thorne, A, additional, Tillett, R, additional, Tolkien, Z, additional, Tomlins, A, additional, Topps, A, additional, Tsang, F, additional, Turner, EJ, additional, Turton, P, additional, Udayasankar, S, additional, Ugolini, F, additional, Vaughan Williams, E, additional, Vidya, R, additional, Vijaynagar, B, additional, Vinayagam, R, additional, Volleamere, A, additional, Voynov, V, additional, Waheed, S, additional, Walker, T, additional, Walsh, U, additional, Warner, R, additional, Waters, R, additional, Wilkins, A, additional, Williams, K, additional, Wilson, G, additional, Wiltsher, M, additional, Wooler, B, additional, Wright, C, additional, Wright, M, additional, Wyld, L, additional, Youssef, M, additional, Zabkiewicz, C, additional, Zammit, C, additional, Zeidan, B, additional, and Zheng, D, additional

Published
2019
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36. VALUABLE COMPOUNDS COMPOSITION OF BERRIES PROCESSING SIDE STREAM.

Author

POPA, M. E., MITELUȚ, A. C., POPA, E. E., DRĂGHICI, M. C., POPESCU, P. A., POPA, V. I., DĂNĂILĂ-GUIDEA, S., and STAN, A.

Subjects
BERRIES, FUNCTIONAL foods, FOOD industry, POLLUTION, BIOACTIVE compounds, FRUIT
Abstract

Fruit by-products resulted from processing represent one of the major environmental pollution problems. Much research focused on bioactive compounds extraction from these by-products, in order to be further used in different industries such as food, pharmaceutic, materials, etc. This study aims to assess a literature review of the composition in valuable compounds of various by-products from fruits, with a potential use as functional ingredients in food industry. [ABSTRACT FROM AUTHOR]

Published
2021

37. Current practice and short-term outcomes of therapeutic mammaplasty in the international TeaM multicentre prospective cohort study

Author

O'Connell, R L, primary, Baker, E, additional, Trickey, A, additional, Rattay, T, additional, Whisker, L, additional, Macmillan, R D, additional, Potter, S, additional, Achuthan, R, additional, Aggarwal, S, additional, Basu, N, additional, Brock, L, additional, Fairbrother, P, additional, Gardiner, M D, additional, Holcombe, C, additional, Ives, C, additional, Jain, A, additional, Kim, B, additional, Murphy, J, additional, Remoundos, D, additional, Sutton, R, additional, Turton, P, additional, Williams, K, additional, MacLeod, C, additional, Smyth, E, additional, Depasquale, I, additional, Fuller, M, additional, Saeed, N, additional, Masannat, Y, additional, Tan Mohd Amin, A, additional, Agrawal, A, additional, Irwin, G, additional, Sloan, S, additional, Refsum, S, additional, McIntosh, S, additional, Ibrahim, A, additional, Sahu, A, additional, Govindarajulu, S, additional, Cawthorn, S, additional, Accurso, A, additional, Rathinaezhil, R, additional, Wilkins, A, additional, Khalifa, E, additional, Grover, K, additional, McManus, P, additional, Kneeshaw, P, additional, Mahapatra, T, additional, Azmy, I, additional, Massey, J, additional, Trapszo, P, additional, lane, R, additional, Seetharam, S, additional, Rocco, N, additional, Roshanlall, C, additional, Kokan, J, additional, Amin, K, additional, Leeper, A, additional, Kulkarni, D, additional, Dixon, J M, additional, Young, O, additional, Saleem, T, additional, McIlhenny, J, additional, Malyon, A, additional, Mansell, J, additional, Ogsto, K, additional, Romics, L, additional, Dragoumis, D, additional, Krupa, J, additional, Valassiadou, K, additional, Lambert, K, additional, Kaushik, M, additional, Shokuhi, S, additional, Pilgrim, S, additional, Wei, X, additional, Lee, J, additional, Al Allak, A, additional, Fowler, C, additional, Massey, E, additional, Court, F, additional, Hunt, R, additional, Vestey, S, additional, Khalil, H, additional, Elgammal, M, additional, Parvanta, L, additional, Sami, A S, additional, Gvaramadze, A, additional, Thekkinkattil, D, additional, Kirkpatrick, K, additional, James, R, additional, Noshirwani, A, additional, Arif, T, additional, Kryjak, Z, additional, Taylor, A, additional, Syed, F H, additional, Safdar, G, additional, Chin, K, additional, Soulsby, R, additional, Thorne, A, additional, Guest, F, additional, El Abbar, M, additional, Munnoch, D A, additional, Macaskill, E J, additional, Hogg, F, additional, McGee, P, additional, Pitsinis, V, additional, Smith, J, additional, Makkiyah, S, additional, Mustafa, S, additional, Otieno, C, additional, Photiou, D, additional, Macmillan, D, additional, Gutteridge, E, additional, Mazari, F, additional, Oni, G, additional, Khout, H, additional, Kelsall, J, additional, Hallam, K, additional, Asgeirron, K, additional, D'Auria, M, additional, Al zubaidi, S, additional, McCulley, S, additional, Rasheed, T, additional, Bailey, J, additional, Muhibullah, N, additional, Tenovici, A, additional, Remoundos, D D, additional, Chaidos, N, additional, Predescu, O, additional, Roy, P, additional, Windle, R, additional, Popa, E, additional, Shetty, G, additional, Rezulski, J, additional, Goh, S, additional, Abdullah, T, additional, Khawaja, S, additional, Udayasankar, S, additional, Tebbal, S, additional, Grassi, V, additional, Talbot, A, additional, Singh, J, additional, Smith, A, additional, Volleamere, A, additional, Garnsey, C, additional, Pikoulas, P, additional, Ferguson, D, additional, Tillett, R, additional, Dean, S, additional, Olsen, S, additional, Rainsbury, R M, additional, Peiris, L, additional, Sjokvist, O, additional, Laws, S, additional, Tansley, A, additional, De Sousa, E, additional, Mitchell, G, additional, Henderson, J, additional, Chandrashekar, M, additional, Micha, A, additional, Godden, A, additional, Pereira, B, additional, Constantinou, C, additional, Rusby, J, additional, Krupa, K, additional, To, N, additional, Barry, P, additional, Critchley, A, additional, Cain, H, additional, O'Donoghue, J, additional, Henton, J, additional, Kalra, L, additional, MacLennan, L, additional, Bennett, R, additional, Nicholson, S, additional, Paolini, G, additional, Francesco Renzi, L, additional, Di Pompeo, S, additional, Ria, V, additional, Hu, J, additional, Johnson, L, additional, Lewis, R S, additional, Hadad, S, additional, Sundaramoorthy, S, additional, Sharma, A, additional, Toomey, D, additional, Banerjee, D, additional, Shuk Kay Tang, S, additional, Taylor, L, additional, McKenzie, S, additional, Ahmad, T, additional, Absar, M, additional, Nasir, N, additional, Jerzy Rychlik, I, additional, Darragh, L, additional, Johnston, R, additional, Kirk, S, additional, Rees Lee, J, additional, Green, M, additional, Chong, K, additional, Lai, L M, additional, Choong, J, additional, Ullah, Z, additional, Chagla, L, additional, Koshy, O, additional, Bathla, S, additional, Kiernan, T, additional, Ashok Bhojwani, A, additional, Lund, J, additional, James, K, additional, Callaghan, M, additional, Vinayagam, R, additional, Poonawala, S, additional, Taylor, J, additional, Mullan, M, additional, Bright Thomas, R, additional, Gandhi, A, additional, Byrne, G, additional, Ibrahim, I, additional, Harvey, J, additional, Highton, L, additional, Chrysafi, A, additional, Jones, R Hawley, additional, Barnes, N, additional, Morris, O, additional, Chatterjee, S, additional, Mathen, V, additional, Majeed, Y, additional, Kirwan, C, additional, Jones, B Mancey, additional, El Sharief, D, additional, Munot, K, additional, Nasr, R, additional, and Frame, R, additional

Published
2018
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40. Cercetări arheologice în aşezarea eneolitică de la Mălăieştii de Jos (jud. Prahova), campaniile 2002–2010

Author

Frînculeasa, A., Andreescu, R., Negrea, O., Niță, L., Frînculeasa, M., Popa, E., and Preda, B.

Subjects
dwellings, tombe, pottery, habitation, époque byzantine, fosse ménagère, évacuation des eaux ménagères, settlement, forteresse, Archaeology, eneolithic, vărbilău river, the stoicani-aldeni aspect, rue, céramique, mur d’enceinte, site archéologique, CC1-960
Abstract

North of the Mălăieştii de Jos village (Prahova county), on the edge of a high terrace (295 m altitude), an Eneolithic settlement was noted. To the north and south the site is naturally bordered by deep gullies and ravines, and to the east by the river valley. A rather easy way of access, probably manmade. exists on its west side. The settlement is located in the hilly area at the northern limit of a microzone characterized by relatively high and extensive terraces, at 3.3 km north from the confluence of the Vărbilău and Teleajen rivers. Despite the fact that the southern part of the Mornel terrace covers a large area where the settlement could have been conveniently located, the Eneolithic community preferred this remote edge of the terrace because of its natural protection from three sides, and probably cut an access path to ensure its isolation. 2002 saw the beginning of the systematic archaeological research, within a project focusing on the dynamics and evolution of the Neo-Eneolithic communities in the northern Wallachia. The excavation system emplyed aimed to completely expose the habitation features, not only for the observing the internal organization of the settlement, but also for obtaining detailed information on the the house building techniques and strategies, distribution of household items, etc. An important part of the research focused on the areas outside the living quarters, in an attempt to improve our understanding of the vertical internal development of the settlement, as well as the horizontal stratigraphic relationships between the various feature uncovereds. In this respect, among other things, it was sought not to isolate the houses from the rest of the archaeological context. In order to obtain such information, the excavation was carried out by simultaneous opening and excavation of large areas. The settlement had one archaeological layer, with several habitation phases. These do not necessarily signify a discontinuity in the evolution of the site, but it rather mirrors the internal evolution of the settlement. These phases could be observed both in the the superposition of the archaeological features, various building facilities and levelings, and the variable thickness of the archaeological layer in different areas of the site. There are places where the cultural layer thickness does not exceed 0.20 m, while in others it reached lower than 0.60– 0.80 m. Several superpositions and intersections of the archaeological features are the markers of the important internal dynamics of this settlement. We were able to identify and observe not only a cumulative stratigraphic evolution, but also the disturbances of the natural and anthropic deposits, as the land was reshuffled in various stages. While excavating we noticed an increased activity in the modeling of the living space. The occuppied perimeter was, naturally restricted and rugged at the same time, and thus various changes were required in order to create additional space, but also to „ isolate” the community. This community reached creative solutions in modelling a restricted space, building homes tailored to the topography. The archaeological research revealed traces of artificial terraces. The settlement covered approx. 4000 sqm, and counted no more than 6 to 8 houses, most likely not all contemporaneous. The dwellings were relatively small, with one or two rooms. It is worth noting the richness of the archaeological finds, especially refitting pottery fragments. Flint and stone tools occured mainly outside the living areas and in waste dumps. Mammal bones were both very rare and poorly preserved.. The archaeological materials discovered indicate the presence of an Eneolithic community with cultural affinities in the Stoicani-Aldeni cultural aspect.

Published
2012

43. 5026Six-segments right ventricular global longitudinal strain predicts survival in patients with pulmonary hypertension receiving specific vasodilator therapy

Author

Enache, R., primary, Popa, E., additional, Badea, R., additional, Dorobantu, D.M., additional, Calin, A., additional, Beladan, C.C., additional, Rosca, M., additional, Mateescu, A., additional, Platon, P., additional, Coman, I.M., additional, Popescu, B.A., additional, and Ginghina, C.C., additional

Published
2017
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44. Tipuri de examinare ecocardiografica Doppler

Author

Muraru, D, Popa, E, Ginghina, C, Popescu, BA, Ginghina, C, Muraru, D, and Popa, E

Subjects
ecocardiografia Doppler, MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE
Published
2011

45. Top-down estimates of European CH4 and N2O emissions based on four different inverse models

Author

Bergamaschi, P., Corazza, M., Karstens, U., Athanassiadou, M., Thompson, L., Pison, I., Manning, A., Bousquet, P., Segers, A., Vermeulen, A., Janssens-Maenhout, G., Schmidt, M., Ramonet, M., Meinhardt, F., Aalto, T., Haszpra, L., Moncrieff, J., Popa, E., Lowry, D., Steinbacher, M., Jordan, A., O'Doherty, S., Piacentino, S., Dlugokencky, E., JRC Institute for Environment and Sustainability (IES), European Commission - Joint Research Centre [Ispra] (JRC), University of Maryland [College Park], University of Maryland System, Max-Planck-Institut für Biogeochemie (MPI-BGC), Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] (LSCE), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), ICOS-RAMCES (ICOS-RAMCES), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Modélisation INVerse pour les mesures atmosphériques et SATellitaires (SATINV), Royal Netherlands Meteorological Institute (KNMI), Umweltbundesamt, Finnish Meteorological Institute (FMI), Hungarian Meteorological Service P.O. Box 39, School of Geosciences [Edinburgh], University of Edinburgh, Department of Earth Sciences [Egham], Royal Holloway [University of London] (RHUL), Swiss Federal Laboratories for Materials Science and Technology [Dübendorf] (EMPA), School of Chemistry, University of Bristol [Bristol], National Oceanic and Atmospheric Administration (NOAA), Sub Atmospheric physics and chemistry, Marine and Atmospheric Research, JRC Institute for Environment and Sustainability ( IES ), European Commission - Joint Research Centre [Ispra] ( JRC ), Max-Planck-Institut für Biogeochemie ( MPI-BGC ), Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] ( LSCE ), Université de Versailles Saint-Quentin-en-Yvelines ( UVSQ ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay-Centre National de la Recherche Scientifique ( CNRS ), ESIM - Déterminants Sociaux de la Santé et du Recours aux Soins ( DS3 ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Royal Netherlands Meteorological Institute ( KNMI ), Service des Photons, Atomes et Molécules ( SPAM ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ), Finnish Meteorological Institute ( FMI ), Department of Earth Sciences [London], Royal Holloway [University of London] ( RHUL ), Swiss Federal Laboratories for Materials Science and Technology [Dübendorf] ( EMPA ), National Oceanic and Atmospheric Administration ( NOAA ), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), and Hungarian Meteorological Service (OMSZ)

Subjects
[ SDU.OCEAN ] Sciences of the Universe [physics]/Ocean, Atmosphere, [SDU.OCEAN]Sciences of the Universe [physics]/Ocean, Atmosphere, Atmospheric pollution, Emission inventory, Earth / Environmental, Modeling, CAS - Climate, Air and Sustainability, Environment, lcsh:QC1-999, lcsh:Chemistry, Europe, lcsh:QD1-999, Urban Development, Pollution monitoring, [ SDU.ENVI ] Sciences of the Universe [physics]/Continental interfaces, environment, ELSS - Earth, Life and Social Sciences, Built Environment, [SDU.ENVI]Sciences of the Universe [physics]/Continental interfaces, environment, lcsh:Physics, ComputingMilieux_MISCELLANEOUS
Abstract

International audience; European CH 4 and N 2 O emissions are estimated for 2006 and 2007 using four inverse modelling systems, based on different global and regional Eulerian and La-grangian transport models. This ensemble approach is designed to provide more realistic estimates of the overall uncertainties in the derived emissions, which is particularly important for verifying bottom-up emission inventories. We use continuous observations from 10 European stations (including 5 tall towers) for CH 4 and 9 continuous stations for N 2 O, complemented by additional European and global discrete air sampling sites. The available observations mainly constrain CH 4 and N 2 O emissions from northwestern and eastern Europe. The inversions are strongly driven by the observations and the derived total emissions of larger countries show little dependence on the emission inventories used a priori. Three inverse models yield 26-56 % higher total CH 4 emissions from northwestern and eastern Europe compared Published by Copernicus Publications on behalf of the European Geosciences Union. 716 P. Bergamaschi et al.: Top-down estimates of European CH 4 and N 2 O emissions to bottom-up emissions reported to the UNFCCC, while one model is close to the UNFCCC values. In contrast, the inverse modelling estimates of European N 2 O emissions are in general close to the UNFCCC values, with the overall range from all models being much smaller than the UNFCCC uncertainty range for most countries. Our analysis suggests that the reported uncertainties for CH 4 emissions might be underestimated , while those for N 2 O emissions are likely overestimated .

Published
2015
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46. Biocompatibility of poly(D,L-lactic-co-hydroxymethyl glycolic acid) microspheres after subcutaneous and subcapsular renal injection

Author

Kazazi-Hyseni, F., Zandstra, J., Popa, E. R., Goldschmeding, R., Lathuile, A. A R, Veldhuis, G. J., Van Nostrum, C. F., Hennink, W. E., Kok, R. J., Sub Drug delivery, Pharmaceutics, Sub Drug delivery, Pharmaceutics, Restoring Organ Function by Means of Regenerative Medicine (REGENERATE), and Nanotechnology and Biophysics in Medicine (NANOBIOMED)

Subjects
Male, Foreign-body giant cell, Biocompatibility, POLY(DL-LACTIDE-CO-GLYCOLIDE) MICROCAPSULES, Polyesters, Monodisperse microspheres, PLGA MICROSPHERES, Pharmaceutical Science, BIODEGRADATION, Biocompatible Materials, Administration, Cutaneous, Kidney, INVIVO DEGRADATION, PLHMGA, Cell Line, POLYMER DEGRADATION, chemistry.chemical_compound, Subcutaneous injection, Drug Stability, In vivo, Taverne, DELIVERY-SYSTEMS, Polymer chemistry, medicine, Animals, Glycolic acid, Cell Proliferation, Drug Carriers, Chromatography, Foreign-Body Reaction, PROTEIN RELEASE, IN-VITRO, FUNCTIONALIZED POLY(ALPHA-HYDROXY ACID)S, Cytocompatibility, PARTICLE-SIZE, Microspheres, Rats, PLGA, medicine.anatomical_structure, chemistry, Drug carrier
Abstract

Poly(D,L-lactic-co-hydroxymethyl glycolic acid) (PLHMGA) is a biodegradable copolymer with potential as a novel carrier in polymeric drug delivery systems. In this study, the biocompatibility of PLHMGA microspheres (PLHMGA-ms) was investigated both in vitro in three different cell types (PK-84, HK-2 and PTECs) and in vivo at two implantation sites (by subcutaneous and subcapsular renal injection) in rats. Both monodisperse (narrow size distribution) and polydisperse PLHMGA-ms were prepared with volume weight mean diameter of 34 and 17 mu m, respectively. Mono and polydisperse PLHMGA-ms showed good cytocompatibility properties upon 72 h incubation with the cells (100 mu g microspheres/600 mu L/cell line). A mild foreign body reaction was seen shortly after subcutaneous injection (20 mg per pocket) of both mono and polydisperse PLHMGA-ms with the presence of mainly macrophages, few foreign body giant cells and myofibroblasts. This transient inflammatory reaction diminished within 28 days after injection, the time-point at which the microspheres were degraded. The degradation profile is comparable to the in vitro degradation time of the microspheres (i.e., within 35 days) when incubated at 37 degrees C in phosphate buffered saline. Subcapsular renal injection of monodisperse PLHMGA-ms (10 mg) in rats was characterized with similar inflammatory patterns compared to the subcutaneous injection. No cortical damage was observed in the injected kidneys. In conclusion, this study demonstrates that PLHMGA-ms are well tolerated after in vivo injection in rats. This makes them a good candidate for controlled delivery systems of low-molecular weight drugs as well as protein biopharmaceuticals. (C) 2014 Elsevier B.V. All rights reserved.

Published
2014

48. New PLA/ZnO:Cu/Ag bionanocomposites for food packaging

Author

Vasile, C., primary, Rapa, M., additional, Stefan, M., additional, Stan, M., additional, Macavei, S., additional, Darie-Nita, R. N., additional, Barbu-Tudoran, L., additional, Vodnar, D. C., additional, Popa, E. E., additional, Stefan, R., additional, Borodi, G., additional, and Brebu, M., additional

Published
2017
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49. The isotopic composition of CO in car exhaust

Author

Naus, S., Röckmann, T. (Thesis Advisor), Popa, E., Naus, S., Röckmann, T. (Thesis Advisor), and Popa, E.

Abstract

In this study, the isotopic composition of CO and of CO$_2$ and the CO:CO$_2$, CH$_4$:CO$_2$ and H$_2$:CO gas ratios in the exhaust of individual cars were investigated. This was done under idling and revving conditions, and for three cars in a full driving cycle on a test bench. The spread in the results, even within a single car, was large: for \delc in CO $\sim$ 0 to -60 \textperthousand, for \delo in CO $\sim$ +20 to +35 \textperthousand, and for all gas ratios several orders of magnitude. The results show an increase in the spread of isotopic values for CO compared to previous studies, suggesting that increasing complexity of emission regulations in cars might be reflected in the isotopic composition. When including all samples, we find a weighted mean for the \delc and \delo in CO of -28.7 $\pm$ 0.5 \perm \ and 24.8 $\pm$ 0.3 \perm \ respectively. This result is dominated by cold petrol cars. Our results suggest that in driving cycles where cold emissions are less important, both \delc and \delo would be expected to increase, which would result in isotopic values more in line with previous studies. For the H$_2$:CO ratio, averaged over all cars, we found a value of 0.71 $\pm$ 0.31 ppb:ppb, in agreement with previous literature. The CO:CO$_2$ ratio, with a mean of 19.4 $\pm$ 6.8 ppb:ppm, and the CH$_4$:CO$_2$ ratio, with a mean of 0.26 $\pm$ 0.05 ppb:ppm, are both higher than is reported in recent literature. This is likely because our sampling distribution was biased towards cold cars, and therefore towards higher emission situations. In many ways the CH$_4$:CO$_2$ ratio was found to behave similarly to the CO:CO$_2$ ratio, suggesting that the processes affecting CO and CH$_4$ are similar. Diesel cars behaved as a distinct group, with CO enriched in $^{13}$C and depleted in $^{18}$O compared to petrol cars. CO emissions from cold diesel cars were found to be significant, but reduced sharply in hot diesel cars. The \delc values in CO$_2$ were close to the \delc

Published
2016

50. Moderated Posters: Imaging of the right heart - What is new?P814Prognostic value of parameters of pulmonary artery stiffness in patients with pulmonary hypertension receiving specific vasodilator therapyP815Reconsidering of inferior vena cava parameters for estimating right atrial pressure: a comparative simultaneous ultrasound-catheterization studyP816Pulmonary hypertension is the main factor echocardiography to predicting mortality in medium and long term in a cohort of patients with heart failureP817Normal values for 3D-right atrial volumes : results from the SKIPOGH-II population studyP818Assessment of right ventricular function by free wall longitudinal strain in organic mitral regurgitationP819Importance of radial dysfunction to determine the impairment of right ventricular ejection fraction in patients with pulmonary hypertensionP820Influence of tricuspid regurgitation severity on non-invasive assessment of right heart hemodynamics: a simultaneous echocardiography-catheterization studyP821Right ventricular failure following ventricular assist device implant: systematic review and meta-analysis of clinical and echocardiographic predictors

Author

Enache, R., primary, Sawada, N., primary, Molina Ferragut, L., primary, Monney, P., primary, Jobbe Duval, A., primary, Peluso, D., primary, Beladan, CC., primary, Diego Bellavia, DB., primary, Popa, E., additional, Jurcut, R., additional, Badea, R., additional, Calin, A., additional, Beladan, CC., additional, Rosca, M., additional, Platon, P., additional, Coman, IM., additional, Popescu, BA., additional, Ginghina, C., additional, Kawata, T., additional, Daimon, M., additional, Kimura, K., additional, Nakao, T., additional, Chiang, S., additional, Mahara, K., additional, Okubo, T., additional, Yatomi, Y., additional, Komuro, I., additional, Uhl, D., additional, Gomez, M., additional, Ble, M., additional, Mas-Stachurska, A., additional, Cladellas, M., additional, Enjuanes, C., additional, Moliner, P., additional, Marti, J., additional, Comin, J., additional, Ehret, G., additional, Crisinel, V., additional, Reverdin, S., additional, Conti, L., additional, Mach, F., additional, Jeanrenaud, X., additional, Bochud, M., additional, Mueller, H., additional, Thebault, O., additional, Poilane, M., additional, Piriou, N., additional, Jaafar, P., additional, Warin-Fresse, K., additional, Serfaty, JM., additional, Cueff, C., additional, Le Tourneau, T., additional, Kovacs, A., additional, Surkova, E., additional, Muraru, D., additional, Perazzolo Marra, M., additional, Iliceto, S., additional, Badano, LP., additional, Predescu, L., additional, Mateescu, AD., additional, Enache, R., additional, Egher, L., additional, Inta, O., additional, Attilio Iacovoni, AI., additional, Sonia Dell'oglio, SD., additional, Giuseppe Romano, GR., additional, Michele Senni, MS., additional, Chiara Mina', CM., additional, Gabriele Di Gesaro, GD., additional, Michele Pilato, MP., additional, Fletcher Miller, FAM, additional, Cesare Scardulla, CS., additional, Francesco Clemenza, FC., additional, Joseph Maalouf, JM., additional, and Michael Dandel, MD., additional

Published
2016
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