Search

Your search keyword '"Pope, J. E."' showing total 177 results
Start Over Author "Pope, J. E."
177 results on '"Pope, J. E."'

3. Palindromic Rheumatism Frequently Precedes Early Rheumatoid Arthritis: Results From an Incident Cohort

Author

Ellingwood, L., Schieir, O., Valois, M. F., Bartlett, S. J., Bessette, L., Boire, G., Hazlewood, G., Hitchon, C., Keystone, E. C., Tin, D., Thorne, C., Bykerk, V. P., Pope, J. E., Baron, Murray, Bessette, Louis, Boire, Gilles, Bykerk, Vivian, Colmegna, Ines, Fallavollita, Sabrina, Haaland, Derek, Haraoui, Paul, Hazlewood, Glen, Hitchon, Carol, Jamal, Shahin, Joshi, Raman, Keystone, Ed, Nair, Bindu, Panopoulos, Peter, Pope, Janet, Rubin, Laurence, Thorne, Carter, Villeneuve, Edith, and Zummer, Michel

Subjects
medicine.medical_specialty, lcsh:Diseases of the musculoskeletal system, business.industry, Swollen joints, General Medicine, Early rheumatoid arthritis, Original Articles, Logistic regression, Clinical disease, medicine.disease, Joint pain, Internal medicine, Cohort, Medicine, Original Article, Palindromic rheumatism, lcsh:RC925-935, medicine.symptom, business, Early arthritis
Abstract

Background This multicenter incident cohort aimed to characterize how often early rheumatoid arthritis (ERA) patients self‐report episodic joint inflammation (palindromic rheumatism) preceding ERA diagnosis and which characteristics differentiate these patients from those without prior episodic symptoms. Methods Data were from patients with early confirmed or suspected RA (more than 6 weeks and less than 12 months) enrolled in the Canadian Early ArThritis CoHort (CATCH) between April 2017 to March 2018 who completed study case report forms assessing joint pain and swelling prior to ERA diagnosis. Chi‐square and t tests were used to compare characteristics of patients with and without self‐reported episodic joint inflammation prior to ERA diagnosis. Multivariable logistic regression was used to identify sociodemographic and clinical measures associated with past episodic joint inflammation around the time of ERA diagnosis. Results A total of 154 ERA patients were included; 66% were female, and mean (SD) age and RA symptom duration were 54 (15) years and 141 (118) days. Sixty‐five (42%) ERA patients reported a history of episodic joint pain and swelling, half of whom reported that these symptoms preceded ERA diagnosis by over 6 months. ERA patients with past episodic joint inflammation were more often female, had higher income, were seropositive, had more comorbidities, fewer swollen joints, and lower Clinical Disease Activity Index (CDAI) around the time of ERA diagnosis (P < 0.05). These associations remained significant in multivariable regression adjusting for other sociodemographic and RA clinical measures. Conclusion Almost half of ERA patients experienced episodic joint inflammation prior to ERA diagnosis. These patients were more often female, had higher income, and presented with milder disease activity at ERA diagnosis.

Published
2019

16. Health Assessment Questionnaire at One Year Predicts All‐Cause Mortality in Patients With Early Rheumatoid Arthritis.

Author

Fatima, Safoora, Schieir, O., Valois, M. F., Bartlett, S. J., Bessette, L., Boire, G., Hazlewood, G., Hitchon, C., Keystone, E. C., Tin, D., Thorne, C., Bykerk, V. P., Pope, J. E., Baron, Murray, Bessette, Louis, Boire, Gilles, Bykerk, Vivian, Colmegna, Ines, Fallavollita, Sabrina, and Haaland, Derek

Subjects
CONFIDENCE intervals, DISABILITY evaluation, QUESTIONNAIRES, RHEUMATOID arthritis, PROPORTIONAL hazards models, DESCRIPTIVE statistics
Abstract

Objective: Higher self‐reported disability (high Health Assessment Questionnaire [HAQ] score) has been associated with hospitalizations and mortality in established rheumatoid arthritis (RA), but associations in early RA are unknown. Methods: Patients with early RA (symptom duration <1 year) enrolled in the Canadian Early Arthritis Cohort who initiated disease‐modifying antirheumatic drugs and had completed HAQ data at baseline and 1 year were included in the study. Discrete‐time proportional hazards models were used to estimate crude and multi‐adjusted associations of baseline HAQ and HAQ at 1 year with all‐cause mortality in each year of follow‐up. Results: A total of 1,724 patients with early RA were included. The mean age was 55 years, and 72% were women. Over 10 years, 62 deaths (3.6%) were recorded. Deceased patients had higher HAQ scores at baseline (mean ± SD 1.2 ± 0.7) and at 1 year (0.9 ± 0.7) than living patients (1.0 ± 0.7 and 0.5 ± 0.6, respectively; P < 0.001). Disease Activity Score in 28 joints (DAS28) was higher in deceased versus living patients at baseline (mean ± SD 5.4 ± 1.3 versus 4.9 ± 1.4) and at 1 year (mean ± SD 3.6 ± 1.4 versus 2.8 ± 1.4) (P < 0.001). Older age, male sex, lower education level, smoking, more comorbidities, higher baseline DAS28, and glucocorticoid use were associated with mortality. Contrary to HAQ score at baseline, the association between all‐cause mortality and HAQ score at 1 year remained significant even after adjustment for confounders. For baseline HAQ score, the unadjusted hazard ratio (HR) was 1.46 (95% confidence interval [95% CI] 1.02–2.09), and the adjusted HR was 1.25 (95% CI 0.81–1.94). For HAQ score at 1 year, the unadjusted HR was 2.58 (95% CI 1.78–3.72), and the adjusted HR was 1.75 (95% CI 1.10–2.77). Conclusion: Our findings indicate that higher HAQ score and DAS28 at 1 year are significantly associated with all‐cause mortality in a large early RA cohort. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

17. There is a need for new systemic sclerosis subset criteria. A content analytic approach

Author

Johnson, S. R., Soowamber, M. L., Fransen, J., Khanna, D., Van den Hoogen, F., Baron, M., Matucci-Cerinic, M., Denton, C. P., Medsger, T. A., Jr., Carreira, P. E., Riemekasten, G., Distler, J., Gabrielli, A., Steen, V., Chung, L., Silver, R., Varga, J., Mueller-Ladner, U., Vonk, M. C., Walker, U. A., Wollheim, F. A., Herrick, A., Furst, D. E., Czirjak, L., Kowal-Bielecka, O., Del Galdo, F., Cutolo, M., Hunzelmann, N., Murray, C. D., Foeldvari, I., Mouthon, L., Damjanov, N., Kahaleh, B., Frech, T., Assassi, S., Saketkoo, L. A., Pope, J. E., Johnson, S. R., Soowamber, M. L., Fransen, J., Khanna, D., Van den Hoogen, F., Baron, M., Matucci-Cerinic, M., Denton, C. P., Medsger, T. A., Jr., Carreira, P. E., Riemekasten, G., Distler, J., Gabrielli, A., Steen, V., Chung, L., Silver, R., Varga, J., Mueller-Ladner, U., Vonk, M. C., Walker, U. A., Wollheim, F. A., Herrick, A., Furst, D. E., Czirjak, L., Kowal-Bielecka, O., Del Galdo, F., Cutolo, M., Hunzelmann, N., Murray, C. D., Foeldvari, I., Mouthon, L., Damjanov, N., Kahaleh, B., Frech, T., Assassi, S., Saketkoo, L. A., and Pope, J. E.

Abstract

Objectives. Systemic sclerosis (SSc) is heterogenous. The objectives of this study were to evaluate the purpose, strengths and limitations of existing SSc subset criteria, and identify ideas among experts about subsets. Methods. We conducted semi-structured interviews with randomly sampled international SSc experts. The interview transcripts underwent an iterative process with text deconstructed to single thought units until a saturated conceptual framework with coding was achieved and respondent occurrence tabulated. Serial cross-referential analyses of clusters were developed. Results. Thirty experts from 13 countries were included; 67% were male, 63% were from Europe and 37% from North America; median experience of 22.5years, with a median of 55 new SSc patients annually. Three thematic clusters regarding subsetting were identified: research and communication; management; and prognosis (prediction of internal organ involvement, survival). The strength of the limited/diffuse system was its ease of use, however 10% stated this system had marginal value. Shortcomings of the diffuse/limited classification were the risk of misclassification, predictions/generalizations did not always hold true, and that the elbow or knee threshold was arbitrary. Eighty-seven percent use more than 2 subsets including: SSc sine scleroderma, overlap conditions, antibody-determined subsets, speed of progression, and age of onset (juvenile, elderly). Conclusions. We have synthesized an international view of the construct of SSc subsets in the modern era. We found a number of factors underlying the construct of SSc subsets. Considerations for the next phase include rate of change and hierarchal clustering (e.g. limited/diffuse, then by antibodies).

Published
2018

18. Reply.

Author

Fatima, Safoora, Schieir, O., Keystone, E. C., Valois, M. F., Bartlett, S. J., Bessette, L., Boire, G., Hazlewood, G., Hitchon, C., Tin, D., Thorne, C., Bykerk, V. P., and Pope, J. E.

Subjects
FUNCTIONAL status, RHEUMATOID arthritis
Abstract

The article discusses the predictive capacity in estimating the risk of all-cause mortality among patients with Rheumatoid Arthritis (RA). Topics include HAQ disability index score, with the results showing similar levels of association with mortality but without improvement in the fit of the model; and Rheumatic Disease Comorbidity Index and could increase the rate of all-cause mortality.

Published
2022
Full Text
View/download PDF

20. Prevalence and Characteristics of Metabolic Syndrome Differ in Men and Women with Early Rheumatoid Arthritis.

Author

Kuriya, B., Schieir, O., Valois, M. F., Pope, J. E., Boire, G., Bessette, L., Hazlewood, G., Thorne, J. C., Tin, D., Hitchon, C., Bartlett, S., Keystone, E. C., Bykerk, V. P., and Barra, L.

Abstract

Objective: Metabolic syndrome (MetS) prevalence in early rheumatoid arthritis (ERA) is conflicting. The impact of sex, including menopause, has not been described. We estimated the prevalence and factors associated with MetS in men and women with ERA. Methods: A cross‐sectional study of the Canadian Early Arthritis Cohort (CATCH) was performed. Participants with baseline data to estimate key MetS components were included. Sex‐stratified logistic regression identified baseline variables associated with MetS. Results: The sample included 1543 participants; 71% were female and the mean age was 54 (SD 15) years. MetS prevalence was higher in men 188 (42%) than women 288 (26%, P < 0.0001) and increased with age. Frequent MetS components in men were hypertension (62%), impaired glucose tolerance (IGT, 40%), obesity (36%), and low high‐density lipoprotein cholesterol (36%). Postmenopausal women had greater frequency of hypertension (65%), IGT (32%), and high triglycerides (21%) compared with premenopausal women (P < 0.001). In multivariate analysis, MetS was negatively associated with seropositivity and pulmonary disease in men. Increasing age was associated with MetS in women. In postmenopausal women, corticosteroid use was associated with MetS. Psychiatric comorbidity was associated with MetS in premenopausal women. MetS status was not explained by disease activity or core RA measures. Conclusion: The characteristics and associations of MetS differed in men and women with ERA. Sex differences, including postmenopausal status, should be considered in comorbidity screening. With this knowledge, the interplay of MetS, sex, and RA therapeutic response on cardiovascular outcomes should be investigated. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

21. Items for developing revised classification criteria in systemic sclerosis: Results of a consensus exercise with the ACR/EULAR working committee for classification criteria in systemic sclerosis

Author

Fransen, J, Johnson, S R, van den Hoogen, F, Baron, M, Allanore, Y, Carreira, P E, Czirják, L, Denton, C P, Distler, O, Furst, D E, Gabrielli, A, Herrick, A, Inanc, M, Kahaleh, B, Kowal-Bielecka, O, Medsger, T A, Mueller-Ladner, U, Riemekasten, G, Sierakowski, S, Valentini, G, Veale, D, Vonk, M C, Walker, U, Chung, L, Clements, P J, Collier, D H, Csuka, M E, Jimenez, S, Merkel, P A, Seibold, J R, Silver, R, Steen, V, Tyndall, A, Matucci-Cerinic, M, Pope, J E, Khanna, D, Fransen, J, Johnson, Sr, van den Hoogen, F, Baron, M, Allanore, Y, Carreira, Pe, Czirják, L, Denton, Cp, Distler, O, Furst, De, Gabrielli, A, Herrick, A, Inanc, M, Kahaleh, B, Kowal Bielecka, O, Medsger TA, Jr, Mueller Ladner, U, Riemekasten, G, Sierakowski, S, Valentini, Gabriele, Veale, D, Vonk, Mc, Walker, U, Chung, L, Clements, Pj, Collier, Dh, Csuka, Me, Jimenez, S, Merkel, Pa, Seibold, Jr, Silver, R, Steen, V, Tyndall, A, Matucci Cerinic, M, Pope, Je, Khanna, D., University of Zurich, and Khanna, D

Subjects
2745 Rheumatology, 10051 Rheumatology Clinic and Institute of Physical Medicine, 610 Medicine & health, Delphi technique, nominal group technique, systemic sclerosis, scleroderma, classification, classification criteria
Abstract

Background Classification criteria for systemic sclerosis (SSc) are being updated. Objective To select a set of items potentially useful for the classification of SSc using consensus procedures including the Delphi and nominal group techniques (NGT). Methods Items were identified through two independent consensus exercises performed by the Scleroderma Clinical Trials Consortium (SCTC) and the EULAR Scleroderma Trials and Research Group (EUSTAR). The first-round items from both exercises were collated and redundancies were removed leaving 168 items. A 3-round Delphi exercise was performed using a 1–9 scale (1=completely inappropriate and 9=completely appropriate) and a consensus meeting using NGT. During the last Delphi, the items were ranked on a 1–10 scale. Results Round 1: 106 experts rated the 168 items. Those with a median score

Published
2012

23. Determining the Minimally Important Difference in the Clinical Disease Activity Index for Improvement and Worsening in Early Rheumatoid Arthritis Patients

Author

Curtis, J. R., primary, Yang, S., additional, Chen, L., additional, Pope, J. E., additional, Keystone, E. C., additional, Haraoui, B., additional, Boire, G., additional, Thorne, J. C., additional, Tin, D., additional, Hitchon, C. A., additional, Bingham, C. O., additional, and Bykerk, V. P., additional

Published
2015
Full Text
View/download PDF

29. FRI0397 Baseline characteristics of systemic sclerosis patients with borderline mean pulmonary artery pressure: post-hoc analysis from the detect study

Author

Khanna, D., primary, Distler, O., additional, Coghlan, J. G., additional, Denton, C. P., additional, Grünig, E., additional, Bonderman, D., additional, Müller-Ladner, U., additional, Pope, J. E., additional, Vonk, M. C., additional, Torres-Martin, J.-V., additional, Doelberg, M., additional, Chadha-Boreham, H., additional, Heinzl, H., additional, Rosenberg, D. M., additional, McLaughlin, V. V., additional, and Seibold, J. R., additional

Published
2013
Full Text
View/download PDF

32. SAT0018 Establishing the Content Validity of Omeract Preliminary Flare Questions (PFQ) for Detecting and Measuring Disease Exacerbations in Rheumatoid Arthritis

Author

Bartlett, S. J., primary, Bingham, C. O., additional, Choy, E., additional, Xiong, J., additional, Boire, G., additional, Haraoui, B., additional, Pope, J. E., additional, Thorne, J. C., additional, Hitchon, C. A., additional, Tin, D., additional, Keystone, E. C., additional, and Bykerk, V. P., additional

Published
2013
Full Text
View/download PDF

35. OP0036 An Evidence-Based Tool for Detection of Pulmonary Arterial Hypertension in Systemic Sclerosis: The Detect Study

Author

Denton, C. P., primary, Coghlan, J. G., additional, Grünig, E., additional, Bonderman, D., additional, Distler, O., additional, Khanna, D., additional, Müller-Ladner, U., additional, Pope, J. E., additional, Vonk, M. C., additional, Doelberg, M., additional, Chadha-Boreham, H., additional, Heinzl, H., additional, Rosenberg, D. M., additional, McLaughlin, V. V., additional, and Seibold, J. R., additional

Published
2013
Full Text
View/download PDF

39. Bosentan treatment of digital ulcers related to systemic sclerosis: results from the RAPIDS-2 randomised, double-blind, placebo-controlled trial

Author

Matucci-Cerinic, M., primary, Denton, C. P., additional, Furst, D. E., additional, Mayes, M. D., additional, Hsu, V. M., additional, Carpentier, P., additional, Wigley, F. M., additional, Black, C. M., additional, Fessler, B. J., additional, Merkel, P. A., additional, Pope, J. E., additional, Sweiss, N. J., additional, Doyle, M. K., additional, Hellmich, B., additional, Medsger, T. A., additional, Morganti, A., additional, Kramer, F., additional, Korn, J. H., additional, and Seibold, J. R., additional

Published
2010
Full Text
View/download PDF

44. The Pharmacology of Spinal Opioids and Ziconotide for the Treatment of Non-Cancer Pain

Author

Pope, J. E., Deer, T. R., Amirdelfan, K., McRoberts, W. P., and Azeem, N.

Abstract

Background: Intrathecal drug delivery has undergone a revitalization following a better understanding of this delivery route and its pharmacokinetics. Driven by patient safety and outcomes, clinicians are motivated to rethink the traditional spinal infusion pump patient selection criteria and indications. We review the current understanding of the pharmacology of commonly employed intrathecal agents and the clinical relevance. Methods: Search strategies for data acquisition included Medline database, PubMed, Google scholar, along with international and national professional meeting content, with key words including pharmacology of opioids, intrathecal therapy, ziconotide, pharmacokinetics, and intrathecal drug delivery. The search results were limited to the English language. Results: Over 300 papers were identified. The literature was condensed and digested to evaluate the most commonly used medications in practice, sto serve as a foundation for review. We review on-label medications: ziconotide and morphine, and off label medications including fentanyl, sufentail, and hydromorphine. Conclusion: Intrathecal therapy has level-one evidence for use for malignant pain and nonmalignant pain, with continued cost savings and improved safety. To most effectively serve our patients, a clear appreciation for the pharmacology of these commonly employed medication is paramount.

Published
2017

50. Immunoglobulin G4-related disease as a mimicker of granulomatosis with polyangiitis: a case report.

Author

Jiang, Z, Wang, D, Jurkiewicz, M, Langdon, KD, Hammond, R, Fernández-Codina, A, Pope, JE, Langdon, K D, and Pope, J E

Subjects
GRANULOMATOSIS with polyangiitis, ANTINEUTROPHIL cytoplasmic antibodies, DISEASES, PLASMA cells, PATHOLOGY
Abstract

Emergent complete spine magnetic resonance imaging (MRI) demonstrated severe cord compression due to soft tissue compression between C3 and T3 (Figure 1). Given the prominent IgG SB 4 sb SP + sp plasma cells on histology, rheumatology was consulted for IgG SB 4 sb -related disease (IgG SB 4 sb -RD) but it was felt that his presentation was more in keeping with granulomatosis with polyangiitis (GPA). Conversely, ANCA elevation in IgG SB 4 sb -RD appears to be rare; therefore, ANCA elevation in any suspected cases of IgG SB 4 sb -RD should prompt further work-up to ensure that ANCA-associated vasculitis is not missed ([7], [8]). [Extracted from the article]

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results