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1. Silicon Ultra fast Cameras for electron and γ sources In Medical Applications: a progress report

Author

Bulgheroni, A., Badano, L., Berst, D., Bianchi, C., Bol, J., Caccia, M., Cappellini, C., Claus, G., Colledani, C., Conte, L., Czermak, A., Deptuch, G., de Boer, W., Domanski, K., Dulinski, W., Dulny, B., Ferrando, O., Grigoriev, E., Grabiec, P., Grodner, M., Lorusso, R., Jaroszewicz, B., Jastrzab, M., Jungermann, L., Klatka, T., Kociubinski, A., Koziel, M., Kucewicz, W., Kucharski, K., Kuta, S., Marczewski, J., Mozzanica, A., Niemec, H., Novario, R., Paolucci, L., Popowski, Y., Prest, M., Przykutta, A., Riester, J.-L., Rovere, M., Sapor, M., Schweickert, H., Sowicki, B., Spanò, B., Szelezniak, M., Tomaszewski, D., and Zalewska, A.

Published
2006
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2. The SUCIMA project: A status report on high granularity dosimetry and proton beam monitoring

Author

Caccia, M., Badano, L., Berst, D., Bianchi, C., Bol, J., Cappellini, C., Claus, G., Colledani, C., Conte, L., Czermak, A., Deptuch, G., de Boer, W., Domanski, K., Dulinski, W., Dulny, B., Ferrando, O., Grigoriev, E., Grabiec, P., Grodner, M., Lorusso, R., Jaroszewicz, B., Jastrzab, M., Jungermann, L., Klatka, T., Kociubinski, A., Koziel, M., Kucewicz, W., Kucharski, K., Kuta, S., Marczewski, J., Mozzanica, A., Niemec, H., Novario, R., Popowski, Y., Prest, M., Przykutta, A., Riester, J.-L., Rovere, M., Sapor, M., Schweickert, H., Sowicki, B., Szelezniak, M., Tomaszewski, D., and Zalewska, A.

Published
2006
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3. Silicon ultra fast cameras for electron and γ sources in medical applications

Author

Cacciaa, M., Airoldi, A., Alemi, M., Amati, M., Badano, L., Bartsch, V., Berst, D., Bianchi, C., Bol, H., Bulgheroni, A., Cannillo, F., Cappellini, C., Czermak, A., Claus, G., Colledani, C., Conte, L., Deptuch, G., de Boer, W., Dierlamm, A., Domanski, K., Dulinski, W., Dulny, B., Ferrando, O., Grigoriev, E., Grabiec, P., Lorusso, R., Jaroszewicz, B., Jungermann, L., Kucewicz, W., Kucharski, K., Kuta, S., Leo, G., Machowski, W., Marczewski, J., Mondry, G., Niemiec, H., Novario, R., Paolucci, L., Pezzetta, M., Popowski, Y., Riester, J-L., Sampietro, C., Sapor, M., Schweickert, H., Spanò, B., Tomaszewski, D., and Zalewska, A.

Published
2003
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6. Outcome of uterine clear cell carcinomas compared to endometrioid carcinomas and poorly-differentiated endometrioid carcinomas

Author

Patrick Petignat, Usel, M., Gauthier, P., Popowski, Y., Pelte, M. F., Bouchardy, C., and Verkooijen, H. M.

Subjects
Aged, 80 and over, ddc:618, Age Factors, Adenocarcinoma, Clear Cell/pathology/radiotherapy/surgery, Survival Analysis, Carcinoma, Endometrioid/pathology/radiotherapy/surgery, Chemotherapy, Adjuvant, Uterine Neoplasms, Humans, Female, Registries, Uterine Neoplasms/pathology/radiotherapy/surgery, Carcinoma, Endometrioid, Switzerland, ddc:613, Adenocarcinoma, Clear Cell, Aged, Retrospective Studies
Abstract

OBJECTIVES: Our aim was to compare the survival between patients with clear cell carcinoma (CC) and patients with endometrioid carcinoma (EC). METHODS: Through the population-based Geneva Cancer Registry, we identified 1,380 resident women diagnosed with uterine cancer between 1970 and 2000. We excluded those with papillary serous endometrial carcinoma and uterine sarcomas. We categorized patients as CC (n = 32, 2.8%) or EC (n = 1,145, 97.2%). Uterine cancer-specific survival rates were calculated by Kaplan-Meier analysis. We used Cox proportional hazards analysis to compare uterine cancer mortality risks between groups, and adjusted these risks for other prognostic factors. RESULTS: CC patients presented with a more advanced stage at diagnosis than EC patients (p = 0.002). Compared to women with EC, women with CC had a significantly greater risk of dying from their disease (hazard ratio [HR] 2.9, 95% confidence interval (95% CI) 1.7-4.9). After adjustment for age, stage and adjuvant chemotherapy, the risk of dying from uterine cancer was still significantly higher for CC patients (HR 2.0, 95% CI 1.2-3.4). By univariate analysis, the risk of dying of endometrial cancer was not significantly higher in CC patients than in patients with poorly-differentiated EC (HR 1.3, 95% CI 0.7-2.3). CONCLUSION: This population-based investigation shows that patients with CC have a poorer outcome than those with EC. Studies to determine the role of adjuvant treatment in CC patients are needed.

Published
2008

7. RD39 Status Report 2004

Author

Borer, K, Janos, S, Pretzl, K, Chen, W, Li, Z, Da Vià, C, Casagrande, L, Grohmann, S, Heijne, Erik H M, Lourenço, C, Niinikoski, T O, Nüssle, G, Perea-Solano, B, Hempel, O, Herzog, R, Wobst, E, Borchi, E, Bruzzi, M, Menichelli, D, Pirollo, S, Popowski, Y, Bates, R, Buttar, C, O'Shea, V, Parkes, C, Hrknen, J, Luukka, P, Tuovinen, E, Tuominen, E, de Boer, Wim, Bol, H, Dierlamm, A, Furgeri, A, Grigoriev, E, Hauler, F, Jungermann, L, Abreu, M, Rato-Mendes, P, Sonderegger, P, Sousa, P, García, E, Lisbon, Cindro, V, Mandic, I, Mikuz, M, Zavrtanik, M, Militaru, O, Piotrzkowski, K, Rouby, X, De Masi, Rita, Paul, S, Buontempo, S, D'Ambrosio, N, Pagano, S, Eremin, V, Ilyashenko, I, Verbitskaya, E, Laiho, R, Vlasenko, L, Vlasenko, M, Anbinderis, P, Anbinderis, T, Gaubas, E, Gorbatenko, V, Kalesinskas, V, Kapturauskas, J, and Vaitkus, J

Subjects
Detectors and Experimental Techniques
Published
2004

8. RD39 Status Report 2003

Author

Borer, K, Janos, S, Pretzl, K, Britvitch, I, Kuznetsov, A A, Musienko, Y, Reucroft, S, Swain, J, Chen, W, Li, Z, Da Vià, C, Casagrande, L, Grohmann, S, Heijne, Erik H M, Lourenço, C, Niinikoski, T O, Nüssle, G, Palmieri, V G, Perea-Solano, B, Hempel, O, Herzog, R, Wobst, E, Borchi, E, Bruzzi, M, Menichelli, D, Pirollo, S, Popowski, Y, O'Shea, V, Rahman, M, Ruggiero, G, Härkönen, J, Luukka, Panja, Tuominen, E, Tuovinen, E, de Boer, Wim, Bol, H, Dierlamm, A, Furgeri, A, Grigoriev, E, Hauler, F, Jungermann, L, Abreu, M, Rato-Mendes, P, Sonderegger, P, Sousa, P, Cindro, V, Mandic, I, Mikuz, M, Zavrtanik, M, Militaru, O, Piotrzkowski, K, Rouby, X, De Masi, R, Paul, S, Buontempo, S, D'Ambrosio, N, Pagano, S, Eremin, V, Ilyashenko, Yu S, Verbitskaya, E, Laiho, R, Vlasenko, L, Vlasenko, M, Anbinderis, P, Anbinderis, T, Gaubas, E, Gorbatenko, V, Kalesinskas, V, Kapturauskas, J, and Vaitkus, J

Subjects
Detectors and Experimental Techniques
Published
2003

9. Silicon Ultra fast Cameras for electron and gamma sources In Medical Applications

Author

Caccia, Massimo, Airoldi, A, Alemi, M, Amati, M, Badano, L, Bartsch, V, Berst, D, Bianchi, C, Bol, H, Bulgheroni, A, Cannillo, F, Cappellini, C, Czermak, A, Claus, G, Colledani, C, Conte, Leopoldo, Deptuch, G, DE BOER, W, Dierlamm, A, Domanski, K, Dulinski, W, Dulny, B, Ferrando, O, Grigoriev, E, Grabiec, P, Lorusso, R, Jaroszewicz, B, Jungermann, L, Kucewicz, W, Kucharski, K, Kuta, S, Leo, G, Machowski, W, Marczewski, J, Mondry, G, Niemiec, H, Novario, Raffaele, Paolucci, L, Pezzetta, M, Popowski, Y, Riester, Jl, Sampietro, C, Sapor, M, Schweickert, H, and S. P. A. .

Published
2003

10. Bolometric Detectors: state of art

Author

Pedretti, M, Airoldi, A, Alemi, M, Amati, M, Badano, L, Bartsch, V, Berst, D, Bianchi, C, Bol, H, Bulgheroni, A, Cannillo, F, Cappellini, C., Czermak, A, Claus, G, Colledani, C, Conte, Leopoldo, Deptuch, G, DE BOER, W, Dierlamm, A, Domanski, K, Dulinski, W, Dulny, B, Ferrando, O, Grigoriev, E, Grabiec, P, Lorusso, R, Jaroszewicz, B, Jungermann, L, Kucewicz, W, Kucharski, K, Kuta, S, Leo, G, Machowski, W, Marczewski, J, Mondry, G, Niemiec, H, Novario, Raffaele, Paolucci, L, Pezzetta, M, Popowski, Y, Riester, Jl, Sampietro, C, Sapor, M, and Schweickert, H

Published
2003

13. Absolute depth-dose-rate measurements for an 192Ir HDR brachytherapy source in water using MOSFET detectors

Author

Zilio, V. O., Joneja, O. P., Popowski, Y., Rosenfeld, Anatoly B., Chawla, R., Zilio, V. O., Joneja, O. P., Popowski, Y., Rosenfeld, Anatoly B., and Chawla, R.

Abstract

Reported MOSFET measurements concern mostly external radiotherapy and in vivo dosimetry. In this paper, we apply the technique for absolute dosimetry in the context of HDR brachytherapy using an 192Ir source. Measured radial dose rate distributions in water for different planes perpendicular to the source axis are presented and special attention is paid to the calibration of the R and K type detectors, and to the determination of appropriate correction factors for the sensitivity variation with the increase of the threshold voltage and the energy dependence. The experimental results are compared with Monte Carlo simulated dose rate distributions. The experimental results show a good agreement with the Monte Carlo simulations: the discrepancy between experimental and Monte Carlo results being within 5% for 82% of the points and within 10% for 95% of the points. Moreover, all points except two are found to lie within the experimental uncertainties, confirming thereby the quality of the results obtained.

Published
2006

16. Recommendations of the EVA GEC ESTRO Working Group: prescribing, recording, and reporting in endovascular brachytherapy. Quality assurance, equipment, personnel and education (vol 59, pg 339, 2001)

Author

UCL - Cliniques universitaires Saint-Luc, UCL - MD/RAIM - Département de radiologie et d'imagerie médicale, Potter, R, Scalliet, Pierre, Van Limbergen, E, Dries, W, Popowski, Y, Coen, V, Fellner, C, Georg, D, Kirisits, C, Levendag, P, Marijnissen, H, Marsiglia, U, Mazeron, JJ, Pokrajac, B, Tamburini, V, UCL - Cliniques universitaires Saint-Luc, UCL - MD/RAIM - Département de radiologie et d'imagerie médicale, Potter, R, Scalliet, Pierre, Van Limbergen, E, Dries, W, Popowski, Y, Coen, V, Fellner, C, Georg, D, Kirisits, C, Levendag, P, Marijnissen, H, Marsiglia, U, Mazeron, JJ, Pokrajac, B, and Tamburini, V

Published
2001

17. Endoluminal beta-radiation therapy for the prevention of coronary restenosis after balloon angioplasty.

Author

Verin, V. (Vitali), Disco, C. (Clemens), Wijns, W. (William), Popowski, Y. (Youri), Bruyne, B. (Bernard) de, Sauerwein, W. (Wolfgang), Lins, M. (Markus), Kovacs, G. (György), Calman, F., Serruys, P.W.J.C. (Patrick), Thomas, M. (Martyn), Baumgart, D. (Dietrich), Verin, V. (Vitali), Disco, C. (Clemens), Wijns, W. (William), Popowski, Y. (Youri), Bruyne, B. (Bernard) de, Sauerwein, W. (Wolfgang), Lins, M. (Markus), Kovacs, G. (György), Calman, F., Serruys, P.W.J.C. (Patrick), Thomas, M. (Martyn), and Baumgart, D. (Dietrich)

Abstract

BACKGROUND: Beta radiation is effective in reducing vascular neointimal proliferation in animals after injury caused by balloon angioplasty. However, the lowest dose that can prevent restenosis after coronary angioplasty has yet to be determined. METHODS: After successful balloon angioplasty of a previously untreated coronary stenosis, 181 patients were randomly assigned to receive 9, 12, 15, or 18 Gy of radiation delivered by a centered yttrium-90 source. Adjunctive stenting was required in 28 percent of the patients. The primary end point was the minimal luminal diameter six months after treatment, as a function of the delivered dose of radiation. RESULTS: At the time of follow-up coronary angiography, the mean minimal luminal diameter was 1.67 mm in the 9-Gy group, 1.76 mm in the 12-Gy group, 1.83 mm in the 15-Gy group, and 1.97 mm in the 18-Gy group (P=0.06 for the comparison of 9 Gy with 18 Gy), resulting in restenosis rates of 29 percent, 21 percent, 16 percent, and 15 percent, respectively (P=0.14 for the comparison of 9 Gy with 18 Gy). At that time, 86 percent of the patients had had no serious cardiac events. In 130 patients treated with balloon angioplasty alone, restenosis rates were 28 percent, 17 percent, 16 percent, and 4 percent, respectively (P=0.02 for the comparison of 9 Gy with 18 Gy). Among these patients, there was a dose-dependent enlargement of the lumen in 28 percent, 50 percent, 45 percent, and 74 percent of patients, respectively (P<0.001 for the comparison of 9 Gy with 18 Gy). The rate of repeated revascularization was 18 percent with 9 Gy and 6 percent with 18 Gy (P=0.26). CONCLUSIONS: Intracoronary beta radiation therapy produces a significant dose-dependent decrease in the rate of restenosis after angioplasty. An 18-Gy dose not only prevents the renarrowing of the lumen typically observed after successful balloon angioplasty, but actually induces luminal enlargement.

Published
2001

18. Mechanisms of neointima formation and remodeling in the porcine coronary artery.

Author

Christen, T., Christen, T., Verin, V., Bochaton-Piallat, M.L., Popowski, Y., Ramaekers, F.C.S., Debruyne, P., Camenzind, E., van Eys, G.J.J.M., Gabbiani, G., Christen, T., Christen, T., Verin, V., Bochaton-Piallat, M.L., Popowski, Y., Ramaekers, F.C.S., Debruyne, P., Camenzind, E., van Eys, G.J.J.M., and Gabbiani, G.

Abstract

Background-To characterize the cells responsible for neointima formation after porcine coronary artery wall injury, we studied the expression of smooth muscle cell (SMC) differentiation markers in 2 models: (1) self-expanding stent implantation resulting in no or little interruption of internal elastic lamina and (2) percutaneous transluminal coronary angioplasty (PTCA) resulting in complete medial rupture and exposure of adventitia to blood components. Methods and Results-The expression of alpha -smooth muscle (SM) actin, SM myosin heavy chain isoforms 1 and 2, desmin, and smoothelin was investigated by means of immunohistochemistry and Western blots in tissues of the arterial wall collected at different time points and in cell populations cultured from these tissues. The expression of smoothelin, a marker of late SMC differentiation, was used to discriminate between SMCs and myofibroblasts. Both stent- and PTCA-induced neointimal tissues and their cultured cell populations expressed all 4 markers. The adventitial tissue underlying PTCA-induced lesions temporarily expressed alpha -SM actin, desmin, and SM myosin heavy chain isoforms, but not smoothelin. When placed in culture, adventitial cells expressed only alpha -SM actin. Conclusions-Our results suggest that SMCs are the main components of coronary artery neointima after both self-expanding stent implantation and PTCA. The adventitial reaction observed after PTCA evolves with a chronology independent of that of neointima formation and probably corresponds to a myofibroblastic reaction.

Published
2001

22. Abstracts from the 8th Annual Meeting of the Scientific Association of Swiss Radiation Oncology (SASRO)

Author

Allal, A. S., primary, Ares, C., additional, Dulguerov, P., additional, Tschanz, E., additional, Verdan, C., additional, Mhawech, P., additional, Riesterer, O., additional, Honer, M., additional, Vuong, V., additional, Jochum, W., additional, Zingg, D., additional, Bodis, S., additional, Ametamey, S., additional, Pruschy, M., additional, Inteeworn, N., additional, Ohlerth, S., additional, Höpfl, G., additional, Roos, M., additional, Wergin, M., additional, Rohrer Bley, C., additional, Gassmann, M., additional, Kaser-Hotz, B., additional, Berthou, S., additional, Aebersold, D. M., additional, Ganapathipillai, S., additional, Streit, B., additional, Stalder, D., additional, Gruber, G., additional, Greiner, R. H., additional, Zimmer, Y., additional, Lutters, G., additional, Krek, W., additional, Tenzer, A., additional, Hofstetter, B., additional, Bonny, C., additional, Azria, A., additional, Larbouret, C., additional, Cunat, S., additional, Ozsahin, M., additional, Zouhair, A., additional, Gourgou, S., additional, Martineau, P., additional, Evans, D. B., additional, Romieu, G., additional, Pujol, P., additional, Pèlegrin, A., additional, Heuberger, J., additional, Kestenholz, P., additional, Taverna, Ch., additional, Lardinois, D., additional, Jörger, M., additional, Schneiter, D., additional, Jerman, M., additional, Weder, W., additional, Stahel, R., additional, Bodis, St., additional, Vees, H., additional, Mach, N., additional, Hügli, A., additional, Balmer Majno, S., additional, Beer, K. T., additional, Friedrich, E. E., additional, Ciernik, I. F., additional, Stanek, N., additional, Taverna, C., additional, Greiner, R., additional, Mahler, F., additional, Landmann, Ch., additional, Studer, G., additional, Bernier, J., additional, Gallino, A., additional, Juelke, Peter D., additional, Hafner, Hans-Peter, additional, Jamshidi, Peiman, additional, Erne, Paul, additional, Resink, Therese Josephine, additional, Thum, Peter, additional, Notter, M., additional, Bargetzi, M., additional, Suleiman, M., additional, Luthi, J. C., additional, Bieri, S., additional, Curschmann, J., additional, Pajic, B., additional, Kranzbühler, H., additional, Lippold, B., additional, Ueltschi, G., additional, Bonetti, M., additional, Nasi, M. L., additional, Price, K. N., additional, Castiglione-Gertsch, M., additional, Rudenstam, C.-M., additional, Holmberg, S. B., additional, Lindtner, J., additional, Gol-ouh, R., additional, Collins, J., additional, Crivellari, D., additional, Carbone, A., additional, Thürlimann, B., additional, Simoncini, E., additional, Fey, M. F., additional, Gelber, R. D., additional, Coates, A. S., additional, Goldhirsch, A., additional, Jeanneret Sozzi, W., additional, Kramar, A., additional, Mirimanoff, R. O., additional, Azria, D., additional, Taussky, D., additional, Becker, M., additional, Kranzbuehler, H., additional, Weitzel, M., additional, Bortoluzzi, L., additional, Behrensmeier, F., additional, Isaak, B., additional, Pasche, P., additional, Luthi, F., additional, Weber, D. C., additional, Lomax, A. J., additional, Rutz, H. P., additional, Pedroni, E. S., additional, Verwey, J., additional, Goitein, G., additional, Timmermann, B., additional, Lomax, A., additional, Bolsi, A., additional, Weber, D., additional, Bentzen, S. M., additional, Khalil, A. A., additional, Saunders, M. I., additional, Horiot, J. C., additional, Van den Bogaert, W., additional, Cummings, B. J., additional, Dische, S., additional, Slosman, D. O., additional, Kebdani, T., additional, Allaoua, M., additional, Stadelmann, O., additional, Stupp, R., additional, Pica, A., additional, Dubois, J. B., additional, Oehler, C., additional, Ulmer, U., additional, Lütolf, U. M., additional, Huser, M., additional, Burger, C., additional, Szekely, G., additional, Davis, J. B., additional, Gervaz, P., additional, Gertsch, P., additional, Morel, Ph., additional, Roth, A. D., additional, Zenklusen, H., additional, Schott, A., additional, Curti, G., additional, Schefer, H., additional, Kolotas, C., additional, Thalmann, G., additional, Vetterli, D., additional, Kemmerling, L., additional, Mini, R., additional, Rouzaud, M., additional, Nouet, P., additional, Mollà, M., additional, Escudé, L., additional, Miralbell, R., additional, Beer, K., additional, von Briel, C., additional, Jichlinski, P., additional, Guillou, L., additional, Fogliata, A., additional, Nicolini, G., additional, Cozzi, L., additional, Hafner, H. P., additional, Hueber, P., additional, Szczerba, D., additional, Born, E. J., additional, Dipasquale, G., additional, Jargy, C., additional, Munier, F., additional, Balmer, A., additional, Do, H. P., additional, Pasche, G., additional, Wang, H., additional, Moeckli, R., additional, Boehringer, T., additional, Coray, A., additional, Lin, S., additional, Pedroni, E., additional, Rutz, H., additional, Baumert, B. G., additional, Norton, I. A., additional, Schoenmaker, E., additional, Krayenbühl, J., additional, Bründler, M.-A., additional, Allemann, K., additional, Laluhovà, D., additional, Collen, T., additional, Coucke, P., additional, Ries, G., additional, Rufibach, K., additional, Huguenin, P., additional, Abdou, M., additional, Girardet, C., additional, Vees, H. J., additional, Bigler, R., additional, Özsoy, O., additional, Bouville, S., additional, Corminboeuf, F., additional, Betz, M., additional, Matzinger, O., additional, Tebeu, P., additional, Popowski, Y., additional, Verkooijen, H., additional, Bouchardy, C., additional, Ludicke, F., additional, Usel, M., additional, Major, A., additional, Merçay, A., additional, Pache, G., additional, Bulling, S., additional, Bressan, S., additional, Valley, J. F., additional, Motta, M., additional, Presilla, S., additional, Richetti, A., additional, Franzetti, A., additional, and Pesce, G., additional

Published
2004
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23. SUCIMA - Silicon Ultra fast Cameras for electron and gamma sources in Medical Applications

Author

Caccia, M., primary, Alemi, M., additional, Badano, L., additional, Bol, J., additional, Berst, D., additional, Bianchi, C., additional, Bulgheroni, A., additional, Cannillo, F., additional, Cappellini, C., additional, Czermak, A., additional, Claus, G., additional, Colledani, C., additional, Conte, L., additional, Deptuch, G., additional, Dierlamm, A., additional, de Boer, W., additional, Domanski, K., additional, Dulinski, W., additional, Dulny, B., additional, Ferrando, O., additional, Grigoriev, E., additional, Grabiec, P., additional, Lorusso, R., additional, Jaroszewicz, B., additional, Jastrzab, M., additional, Jungermann, L., additional, Kucewicz, W., additional, Kucharski, K., additional, Kuta, S., additional, Leo, G., additional, Machowski, W., additional, Marczewski, J., additional, Mondry, G., additional, Niemiec, H., additional, Novario, R., additional, Nowak, L., additional, Pezzetta, M., additional, Popowski, Y., additional, Riester, J.-L., additional, Sampietro, C., additional, Sapor, M., additional, Schweickert, H., additional, Sowicki, B., additional, Tanzi, F., additional, Tomaszewski, D., additional, and Zalewska, A., additional

Published
2003
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31. Screening for cancer, 1995: An update

Author

de Pree, C., primary, Aapro, M.S., additional, Spiliopoulos, A., additional, Popowski, Y., additional, Mermillod, B., additional, Mirimanoff, R.O., additional, and Alberto, P., additional

Published
1995
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33. Gamma-irradiation markedly inhibits the hydrated collagen gel contradiction by arterial smooth muscle cells.

Author

Keller, Pierre-Frederic, Verin, Vitali, Ziegler, Thierry, Mermillod, Bernadette, Popowski, Youri, Delafontaine, Patrice, Keller, P F, Verin, V, Ziegler, T, Mermillod, B, Popowski, Y, and Delafontaine, P

Subjects
ANIMAL experimentation, BIOLOGICAL models, CATTLE, CELL culture, CELL physiology, COLLAGEN, DNA, GAMMA rays, PHARMACEUTICAL gels, DOSE-response relationship (Radiation), RESEARCH funding, SMOOTH muscle, WOUND healing, PHYSIOLOGICAL effects of radiation
Abstract

Background: Vessel wall responses to percutaneous transluminal coronary angioplasty include neointimal proliferation and arterial remodeling. The contraction of a collagen gel is a good in vitro model of wound repair and vascular remodeling. Because irradiation is an important new therapeutic modality capable of preventing restenosis, the purpose of this study was to evaluate the effect of irradiation on the contraction of a collagen gel by smooth muscle cells (SMCs), on SMCs viability, and on DNA synthesis.Methods: We studied the effect of different doses of gamma-irradiation (0 [control], 6, 12, and 18 Gy) on the contraction of a collagen gel seeded with SMCs (calf carotid arteries) during a period of 15 days.Results: Maximal gel diameter reduction (from 35 to 6.8 mm, +/-0.5 mm in control) was markedly inhibited in the 6-, 12-, and 18-Gy groups (35 to 13.7 mm, +/-0.8 mm; 35 to 15.5 mm, +/-0.9 mm; and 35 to 16.1 mm, +/-0.9 mm, respectively; P<0.0001). The irradiated gels showed a dose-dependent reduction in the SMC proliferation rate (P<0.0001) and an increase in the number of nonviable SMCs (P<0.002) 15 days after irradiation.Conclusions: Gamma-irradiation produces a significant dose-dependent inhibition of the contraction of collagen gels seeded with arterial SMCs. This effect is related to a significant decrease in SMC viability and a decrease in SMC proliferation rate. These findings shed light on mechanisms whereby irradiation may positively affect arterial remodeling after percutaneous transluminal coronary angioplasties. [ABSTRACT FROM AUTHOR]

Published
2001
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41. 144Ce as a potential candidate for interstitial and intravascular brachytherapy

Author

Zilio, V. O., Joneja, O. P., Popowski, Y., Bochud, F. O., and Chawla, R.

Subjects
cerium, dosimetry, brachytherapy, phantoms, ionisation chambers, Monte Carlo methods, calibration
Abstract

To investigate the suitability of 144Ce for both interstitial and intravascular brachytherapy applications. Monte Carlo calculations of radial dose rate distributions in water were performed for 144Ce in a spring-shaped source and compared with two commonly used interstitial and intravascular sources, 192Ir and 32P. The numeric simulations were checked experimentally with a calibrated ionization chamber in a water phantom. Other source characteristics, such as half-life and specific activity, were also compared. For interstitial brachytherapy, 144Ce presents dosimetric advantages over 192Ir in terms of higher dose rate at shorter distances and lower irradiation of organs outside the tumor. The source size and shape reduce the anisotropy and the number of dwell positions necessary. The longer half-life of 144Ce might also be advantageous over 192Ir. For intravascular brachytherapy, 144Ce permits the treatment of larger arteries as compared with 32P, compensates centering errors more effectively, and has a more suitable half-life. The experimental validation showed good agreement (within 10%) with the Monte Carlo simulated dose rate distributions. There are certain potential advantages of using 144Ce as a source for both interstitial and intravascular brachytherapy. The basis for this finding is provided by the Monte Carlo radial dose rate comparisons with 192Ir and 32P, as well as by such characteristics as half-life and specific activity. [All rights reserved Elsevier]

42. RD39 status report

Author

Borer, K., Janos, S., Pretzl, K., Britvich, I., Kuznetsov, A., Musienko, Yu, Reucroft, S., Swain, J., Chen, W., Li, Zheng, Da Via, C., Casagrande, L., Grohmann, S., Heijne, E., Lourenco, C., Niinikoski, T. O., Nussle, G., Palmieri, V. G., Perea Solano, B., Hempel, O., Herzog, R., Wobst, E., Borchi, E., Bruzzi, M., Menichelli, D., Pirollo, S., Popowski, Y., O Shea, V., Rahman, M., Ruggiero, G., Harkonen, J., Luukka, P., Tuominen, E., Tuovinen, E., Boer, W., Bol, J., Dierlamm, A., Furgeri, A., Grigorev, E., Hauler, F., Jungermann, L., Abreu, M. C., Rato-Mendes, P., Sonderegger, P., Sousa, P., Cindro, V., Mandic, I., Mikuz, M., Zavrtanik, M., Militaru, O., Piotrzkowski, K., Rouby, X., Masi, R., Stephan Paul, Buontempo, S., D Ambrosio, N., Pagano, S., Eremin, V., Ilyashenko, I., Verbitskaya, E., Laiho, R., Vlasenko, L., Vlasenko, M., Anbinderis, P., Anbinderis, T., Gaubas, E., Gorbatenko, V., Kalesinskas, V., Kapturauskas, J., and Vaitkus, J.

43. Summary, plan and resources of RD39 projects

Author

Borer, K., Janos, S., Pretzl, K., Chen, W., Li, Z., Da Via, C., Granata, V., Casagrande, L., Collins, P., Grohmann, S., Heijne, E., Lourenco, C., Niinikoski, T. O., Perea Solano, B., Palmieri, V. G., Sonderegger, P., Hempel, O., Herzog, R., Wobst, E., Borchi, E., Bruzzi, M., Lagomarsino, S., Menichelli, D., Pini, S., Sciortino, Silvio, Grigorev, E., Popowski, Y., Bell, W., Devine, S. R. H., O Shea, V., Ruggiero, G., Smith, K., Harkonen, J., Tuominen, E., Boer, W., Dierlamm, A., Hauler, F., Jungermann, L., Abreu, M., Rato-Mendes, P., Sousa, P., Piotrzkowski, K., Graulich, J. S., Vladimir Cindro, Mandic, I., Mikuz, M., Zavrtanik, M., Masi, R., Paul, S., Buontempo, S., D Ambrosio, N., Pagano, S., Laiho, R., Vlasenko, L., Vlasenko, M., Eremin, V., and Verbitskaya, E.

Subjects
Detectors and Experimental Techniques

44. Absolute depth-dose-rate measurements for an 192Ir HDR brachytherapy source in water using MOSFET detectors

Author

Zilio, V. O., Joneja, O. P., Popowski, Y., Rosenfeld, A., and Chawla, R.

Subjects
MOSFET, dosimetry, Physics::Medical Physics, brachytherapy, Monte Carlo methods, iridium
Abstract

Reported MOSFET measurements concern mostly external radiotherapy and in vivo dosimetry. In this paper, we apply the technique for absolute dosimetry in the context of HDR brachytherapy using an 192Ir source. Measured radial dose rate distributions in water for different planes perpendicular to the source axis are presented and special attention is paid to the calibration of the R and K type detectors, and to the determination of appropriate correction factors for the sensitivity variation with the increase of the threshold voltage and the energy dependence. The experimental results are compared with Monte Carlo simulated dose rate distributions. The experimental results show a good agreement with the Monte Carlo simulations: the discrepancy between experimental and Monte Carlo results being within 5% for 82% of the points and within 10% for 95% of the points. Moreover, all points except two are found to lie within the experimental uncertainties, confirming thereby the quality of the results obtained

45. RD39 status report 2005

Author

Britvich, I., Kuznetsov, A., Musienko, Yu, Reucroft, S., Swain, J., Chen, W., Li, Z., Grohmann, S., Heijne, E., Lourenco, C., Niinikoski, T. O., Nussle, G., Perea Solano, B., Hempel, O., Herzog, R., Wobst, E., Borchi, E., Bruzzi, M., Menichelli, D., Pirollo, S., Popowski, Y., Bates, R., Craig Buttar, O Shea, V., Parkes, C., Harkonen, J., Luukka, P., Tuominen, E., Tuovinen, E., Boer, W., Bol, J., Dierlamm, A., Furgeri, A., Grigoriev, E., Hauler, F., Jungermann, L., Abreu, M. C., Rato-Mendes, P., Sonderegger, P., Sousa, P., Cindro, V., Mandic, I., Mikuz, M., Zavrtanik, M., Militaru, O., Piotrzkowski, K., Rouby, X., Masi, R., Paul, S., Buontempo, S., D Ambrosio, N., Pagano, S., Eremin, V., Ilyashenko, I., Verbitskaya, E., Laiho, R., Vlasenko, L., Vlasenko, M., Anbinderis, P., Anbinderis, T., Gaubas, E., Gorbatenko, V., Kalesinskas, V., Kapturauskas, J., and Vaitkus, J.

47. Impact of 18F-FDG PET/CT on target volume delineation in recurrent or residual gynaecologic carcinoma

Author

Vees Hansjörg, Casanova Nathalie, Zilli Thomas, Imperiano Hestia, Ratib Osman, Popowski Youri, Wang Hui, Zaidi Habib, and Miralbell Raymond

Subjects
Gynaecologic cancer, PET/CT, Radiotherapy, Target volume delineation, Observer variability, Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background To evaluate the impact of 18F-FDG PET/CT on target volume delineation in gynaecological cancer. Methods F-FDG PET/CT based RT treatment planning was performed in 10 patients with locally recurrent (n = 5) or post-surgical residual gynaecological cancer (n = 5). The gross tumor volume (GTV) was defined by 4 experienced radiation oncologists first using contrast enhanced CT (GTVCT) and secondly using the fused 18F-FDG PET/CT datasets (GTVPET/CT). In addition, the GTV was delineated using the signal-to-background (SBR) ratio-based adaptive thresholding technique (GTVSBR). Overlap analysis were conducted to assess geographic mismatches between the GTVs delineated using the different techniques. Inter- and intra-observer variability were also assessed. Results The mean GTVCT (43.65 cm3) was larger than the mean GTVPET/CT (33.06 cm3), p = 0.02. In 6 patients, GTVPET/CT added substantial tumor extension outside the GTVCT even though 90.4% of the GTVPET/CT was included in the GTVCT and 30.2% of the GTVCT was found outside the GTVPET/CT. The inter- and intra-observer variability was not significantly reduced with the inclusion of 18F-FDG PET imaging (p = 0.23 and p = 0.18, respectively). The GTVSBR was smaller than GTVCT p ≤ 0.005 and GTVPET/CT p ≤ 0.005. Conclusions The use of 18F-FDG PET/CT images for target volume delineation of recurrent or post-surgical residual gynaecological cancer alters the GTV in the majority of patients compared to standard CT-definition. The use of SBR-based auto-delineation showed significantly smaller GTVs. The use of PET/CT based target volume delineation may improve the accuracy of RT treatment planning in gynaecologic cancer.

Published
2012
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