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1. EUS-guided fine needle biopsy is able to provide diagnosis in rare osteoclast-like giant cells undifferentiated carcinoma of the pancreas: report of two cases

Author

Pop Ruxandra Mihaela, Diaconu Claudia Irina, Rimbaş Mihai, Mateescu Radu Bogdan, Rouhani Farid, Popp Cristiana, Manfrin Erminia, Crinò Stefano Francesco, and Cauni Victor

Subjects
endoscopic ultrasound-guided fine needle aspiration, endoscopic ultrasound-guided fine needle biopsy, immunohistochemistry, osteoclast-like giant cell, pancreatic cancer, tumor markers, Internal medicine, RC31-1245
Abstract

Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells (UC-OGC) is a rare subtype of pancreatic cancer, accounting for less than 1% of all pancreatic tumors. Preoperative diagnosis is cumbersome as cross-sectional imaging is often not capable to distinguish between UC-OGC and other pancreatic tumors such as pancreatic adenocarcinoma, mucinous carcinoma or neuroendocrine tumors and specific tumor markers seem to be lacking. Endoscopic ultrasound r `m(EUS) with tissue acquisition via fine-needle aspiration (FNA) or biopsy (FNB) with microscopic HE staining and immunohistochemistry allows for an accurate diagnosis, thus influencing further treatment. We present herein the cases of two patients with osteoclast-like giant cells tumors of the pancreas diagnosed by EUS-guided fine needle biopsy and perform a literature review on the role of EUS-guided biopsy for diagnosis.

Published
2023
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2. Characteristics and outcomes of patients with COVID-19 and liver injury: a retrospective analysis and a multicenter experience

Author

Voiosu Andrei, Roman Adina, Pop Ruxandra, Boeriu Alina, Popp Cristiana, Zurac Sabina, Voiosu Theodor, Dobru Daniela, and Mateescu Bogdan

Subjects
covid-19, liver injury, sars-cov-2, drug-induced liver injury, hepatitis, hydroxychloroquine, lopinavir/ritonavir, antiviral therapy, Internal medicine, RC31-1245
Abstract

Background and aims. Patients with COVID-19 frequently present abnormal elevated liver function tests of unknown clinical significance. We aimed to investigate the characteristics and factors influencing outcome in patients with confirmed SARS-CoV-2 infection and liver injury on admission.

Published
2022
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3. Skin Malignant Melanoma and Matrix Metalloproteinases: Promising Links to Efficient Therapies.

Author

Lazar, Angela Madalina, Costea, Daniel Ovidiu, Popp, Cristiana Gabriela, and Mastalier, Bogdan

Subjects
MATRIX metalloproteinases, MELANOMA, CUTANEOUS malignant melanoma, GENETIC mutation, DEATH rate, SKIN
Abstract

Skin malignant melanoma (MM) is one of the most frequent and aggressive neoplasia worldwide. Its associated high mortality rates are mostly due to its metastases, while diagnosis and treatment of MM in its early stages is of favorable prognostic. Even skin superficial MMs at incipient local stages can already present with lymph node invasion and distant metastases. Therefore, knowledge of the controllable risk factors and pathogenic mechanisms of MM development, spreading, and metastatic pattern, as well as early diagnosis, are essential to decrease the high mortality rates associated with cutaneous malignant melanoma. Genetic factors are incriminated, although lifetime-acquired genetic mutations appear to be even more frequently involved in the development of MM. Skin melanocytes divide only twice per year and have time to accumulate genetic mutations as a consequence of environmental aggressive factors, such as UV exposure. In the search for more promising therapies, matrix metalloproteinases have become of significant interest, such as MMP-1, MMP-2, MMP-9, and MMP-13, which have been linked to more aggressive forms of cancer and earlier metastases. Therefore, the development of specific synthetic inhibitors of MMP secretion or activity could represent a more promising and effective approach to the personalized treatment of MM patients. [ABSTRACT FROM AUTHOR]

Published
2024
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4. A New Method of Artificial-Intelligence-Based Automatic Identification of Lymphovascular Invasion in Urothelial Carcinomas

Author

Ceachi, Bogdan, primary, Cioplea, Mirela, additional, Mustatea, Petronel, additional, Gerald Dcruz, Julian, additional, Zurac, Sabina, additional, Cauni, Victor, additional, Popp, Cristiana, additional, Mogodici, Cristian, additional, Sticlaru, Liana, additional, Cioroianu, Alexandra, additional, Busca, Mihai, additional, Stefan, Oana, additional, Tudor, Irina, additional, Dumitru, Carmen, additional, Vilaia, Alexandra, additional, Oprisan, Alexandra, additional, Bastian, Alexandra, additional, and Nichita, Luciana, additional

Published
2024
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6. RFA-INDUCED ALTERATIONS IN THE EXPRESSION OF PD-1 AND CTLA-4 IN THE TUMOUR MICROENVIRONMENT pCCA: RESULTS FROM AN EXPLORATORY STUDY.

Author

GĂLĂȚEANU, BIANCA, GINGHINĂ, OCTAV, HUDIȚĂ, ARIANA, TUDORACHE, RALUCA-SILVANA, ZAMFIR, MARIUS-COSMIN, MARDARE, MARA, LAMBERT, CLAUDE, BÎRLIGEA, MIHAELA, DIACONU, CLAUDIA, POPP, CRISTIANA, BURCEA-DRAGOMIROIU, GEORGE-TRAIANALEXANDRU, VOIOSU, ANDREI, and VOIOSU, THEODOR

Subjects
CYTOTOXIC T lymphocyte-associated molecule-4, PROGRAMMED cell death 1 receptors, TUMOR microenvironment, IMMUNE checkpoint inhibitors, CATHETER ablation
Abstract

Copyright of Farmacia is the property of Societatea de Stiinte Farmaceutice Romania and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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12. Correlations Between the Density of Tryptase Positive Mast Cells (DMCT) and that of New Blood Vessels (CD105+) in Patients with Gastric Cancer

Author

Micu Gianina Viorica, Stăniceanu Florica, Sticlaru Liana Cătălina, Popp Cristiana Gabriela, Bastian Alexandra Eugenia, Gramada Eliza, Pop. G., Mateescu R. B., Rimbaş M., Archip Bianca, and Bleotu Coralia

Subjects
gastric cancer, mast cells, tryptase, new vessel density, helicobacter pylori infection, Internal medicine, RC31-1245
Abstract

Mast cells proteases, tryptase and chymase are directly involved in the growth and progression of solid tumors due to their important role in tumor angiogenesis. We examined the density of tryptase positive mast cells and the mean density of new blood vessels in gastric malignant tumors of patients with and without Helicobacter pylori infection, using immunohistochemical staining for tryptase (for mast cells) and CD 105 (for new vessels). Tryptase and CD 105 expression was detected in gastrectomy specimens. In this study, mast cell density correlates with angiogenesis and the growth and progression of gastric cancer. It also shows that the participation of Helicobacter pylori infection in the growth and progress of gastric neoplasia is due to an increase of peritumoral angiogenesis, with subsequent local and distant tumor spread and perivascular growth, but without perineural and nodal involvement.

Published
2016
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13. The prognostic significance of the clinical and histological parameters in primary cutaneous melanoma patients

Author

Antohe, Mihaela, primary, Coman, Anastasia, primary, Turcu, Gabriela, primary, Nedelcu, Roxana Ioana, primary, Brinzea, Alice, primary, Balaban, Mihaela, primary, Moroianu, Andreea, primary, Manea, Lorena, primary, Hulea, Ionela, primary, Balasescu, Elena, primary, Zurac, Sabina Andrada, primary, Cioplea, Mirela, primary, Popp, Cristiana, primary, Nichita, Luciana, primary, and Ion, Daniela Adriana, primary

Published
2022
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14. A New Artificial Intelligence-Based Method for Identifying Mycobacterium Tuberculosis in Ziehl–Neelsen Stain on Tissue

Author

Zurac, Sabina, primary, Mogodici, Cristian, additional, Poncu, Teodor, additional, Trăscău, Mihai, additional, Popp, Cristiana, additional, Nichita, Luciana, additional, Cioplea, Mirela, additional, Ceachi, Bogdan, additional, Sticlaru, Liana, additional, Cioroianu, Alexandra, additional, Busca, Mihai, additional, Stefan, Oana, additional, Tudor, Irina, additional, Voicu, Andrei, additional, Stanescu, Daliana, additional, Mustatea, Petronel, additional, Dumitru, Carmen, additional, and Bastian, Alexandra, additional

Published
2022
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15. EUS-FNB WITH WET-SUCTION VERSUS SLOW-PULL FOR DIAGNOSIS OF SOLID LESIONS: INTERIM ANALYSIS OF AN INTERNATIONAL RANDOMIZED, CROSS-OVER TRIAL

Author

Crinò, Stefano Francesco, primary, Conti Bellocchi, Maria Cristina, additional, Di Mitri, Roberto, additional, Inzani, Frediano, additional, Rimbas, Mihai, additional, Lisotti, Andrea, additional, Manfredi, Guido, additional, Teoh, Anthony Y., additional, Mangiavillano, Benedetto, additional, Sendino, Oriol, additional, Bernardoni, Laura, additional, Manfrin, Erminia, additional, Scimeca, Daniela, additional, Unti, Elettra, additional, Carlino, Angela, additional, Voiosu, Theodor, additional, Popp, Cristiana, additional, Fusaroli, Pietro, additional, Lega, Stefania, additional, Buscarini, Elisabetta, additional, Pergola, Lorena, additional, Chan, Shannon M., additional, Lamonaca, Laura, additional, Ginès, Angel, additional, Fernández-Esparrach, Gloria, additional, Facciorusso, Antonio, additional, and Larghi, Alberto, additional

Published
2022
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16. Role of immunohistochemistry in the diagnosis and staging of cutaneous squamous‑cell carcinomas (Review)

Author

Bălășescu, Elena, primary, Gheorghe, Andreea-Cristina, additional, Moroianu, Andreea, additional, Turcu, Gabriela, additional, Brînzea, Alice, additional, Antohe, Mihaela, additional, Hodorogea, Anastasia, additional, Manea, Lorena, additional, Balaban, Mihaela, additional, Andrei, Răzvan, additional, Hulea, Ionela, additional, Popp, Cristiana, additional, Nichita, Luciana, additional, Cioplea, Mirela, additional, Zurac, Sabina, additional, Ion, Daniela, additional, and Nedelcu, Roxana, additional

Published
2022
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17. Coexistence of Trisomy 8 and 13 in a Newly Diagnosed Patient With Diffuse Large B Cell Non-Hodgkin Lymphoma and Acute Myeloid Leukemia Secondary to Primary Myelofibrosis

Author

Bumbea, Horia, primary, Popov, Viola Maria, additional, Tomuleasa, Ciprian, additional, Omer, Meilin, additional, Dobrea, Camelia, additional, Manea, Irina, additional, Zurac, Sabina, additional, Popp, Cristiana, additional, Dumitru, Ion, additional, Simoiu, Madalina, additional, and Mastalier, Bogdan, additional

Published
2022
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20. FOXP3 in Melanoma with Regression: Between Tumoral Expression and Regulatory T Cell Upregulation

Author

Cioplea, Mirela, Nichita, Luciana, Georgescu, Daniela, Sticlaru, Liana, Cioroianu, Alexandra, Nedelcu, Roxana, Turcu, Gabriela, Rauta, Alin, Mogodici, Cristian, Zurac, Sabina, and Popp, Cristiana

Subjects
Article Subject, chemical and pharmacologic phenomena
Abstract

Cutaneous melanoma is a significant immunogenic tumoral model, the most frequently described immune phenomenon being tumor regression, as a result of the interaction of tumoral antigens and stromal microenvironment. We present a retrospective cohort study including 52 cases of melanoma with regression. There were evaluated correlations of the most important prognostic factors (Breslow depth and mitotic index) with FOXP3 expression in tumor cells and with the presence of regulatory T cells and dendritic cells in the tumoral stroma. FOXP3 expression in tumor cells seems an independent factor of poor prognosis in melanoma, while regression areas are characterized by a high number of dendritic cells and a low number of regulatory T cells. FOXP3 is probably a useful therapeutical target in melanoma, since inhibition of FOXP3-positive tumor clones and of regulatory T cells could eliminate the ability of tumor cells to escape the immune defense of the host.

Published
2020
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22. Epithelial-Mesenchymal Transition in Skin Cancers: A Review

Author

Hodorogea, Anastasia, primary, Calinescu, Andreea, additional, Antohe, Mihaela, additional, Balaban, Mihaela, additional, Nedelcu, Roxana Ioana, additional, Turcu, Gabriela, additional, Ion, Daniela Adriana, additional, Badarau, Ioana Anca, additional, Popescu, Catalin Mihai, additional, Popescu, Raluca, additional, Popp, Cristiana, additional, Cioplea, Mirela, additional, Nichita, Luciana, additional, Hulea, Ionela, additional, and Brinzea, Alice, additional

Published
2019
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29. Histologic Features with Predictive Value for Outcome of Patients with Ulcerative Colitis

Author

Popp, Cristiana

Subjects
Medical / Gastroenterology
Abstract

Ulcerative colitis is an inflammatory bowel disease with variable evolution, in which is difficult to establish patient’s outcome. Histology is an important part of diagnosis of ulcerative colitis and has an increasing role in patients’ management, since increasingly more histologic features with predictive value are being identified and validated. This chapter presents the most important histologic prognostic factors that should be included in histologic reports of patients with ulcerative colitis. Basal plasmacytosis and histologic healing are the most significant validated factors of prognosis in ulcerative colitis, while dysplasia is important since colorectal carcinoma is a severe complication of the disease.

Published
2018

30. Efficacy of methotrexate as anti‑inflammatory and anti‑proliferative drug in dermatology: Three case reports

Author

Nedelcu, Roxana‑Ioana, primary, Balaban, Mihaela, additional, Turcu, Gabriela, additional, Brinzea, Alice, additional, Ion, Daniela, additional, Antohe, Mihaela, additional, Hodorogea, Anastasia, additional, Calinescu, Andreea, additional, Badarau, Anca, additional, Popp, Cristiana, additional, Cioplea, Mirela, additional, Nichita, Luciana, additional, Popescu, Silvia, additional, Diaconu, Carmen, additional, Bleotu, Coralia, additional, Pirici, Daniel, additional, Popescu, Raluca, additional, Popescu, Catalin, additional, and Zurac, Sabina, additional

Published
2019
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33. Tumor infiltrating lymphocytes: The regulator of melanoma evolution (Review)

Author

Antohe, Mihaela, primary, Nedelcu, Roxana, additional, Nichita, Luciana, additional, Popp, Cristiana, additional, Cioplea, Mirela, additional, Brinzea, Alice, additional, Hodorogea, Anastasia, additional, Calinescu, Andreea, additional, Balaban, Mihaela, additional, Ion, Daniela, additional, Diaconu, Carmen, additional, Bleotu, Coralia, additional, Pirici, Daniel, additional, Zurac, Sabina, additional, and Turcu, Gabriela, additional

Published
2019
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37. Bacillary angiomatosis triggered by severe trauma in a healthy Caucasian patient: A case report.

Author

Balaban, Mihaela, Ioana Nedelcu, Roxana, Balmes, Gabriela, Adela Todorovic, Teodora, Brinzea, Alice, Nichita, Luciana, Gabriela Popp, Cristiana, Theodor Andrei, Razvan, Andrada Zurac, Sabina, Adriana Ion, Daniela, and Turcu, Gabriela

Subjects
VASCULAR endothelial growth factors, ERYTHROMYCIN, BRAIN abscess
Abstract

Bacillary angiomatosis represents a cutaneous and systemic infection caused by Bartonella species, typically described in the past in HIV-positive patients or associated with immunodeficiencies. More recent case reports had brought into attention the probability that this entity may manifest in otherwise healthy individuals, triggered by trauma and skin burns. The physiopathology of this neoproliferative process is based on the production of angiogenetic molecules, such as vascular endothelial growth factor (VEGF) and IL-8. In case of an inadequate treatment, the evolution can be fatal, with a systemic dissemination of the abscesses within the gastro-intestinal tract, respiratory tract, brain and bones. The appropriate therapy is with oral erythromycin and doxycycline, but several treatments such as cephalosporins, penicillins, macrolides, aminoglycosides, rifampin, dapsone, ciprofloxacin, have been tried with favorable results. Herein we present the case of a Caucasian patient, seronegative for HIV, who developed multiple vascular papules and nodules on the face, after a severe trauma and which healed after an adequate antibiotic therapy with oral clarithromycin. [ABSTRACT FROM AUTHOR]

Published
2020
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38. Pyoderma gangrenosum and suppurative hidradenitis association, overlap or spectrum of the same disease? Case report and discussion.

Author

Turcu, Gabriela, Ioana Nedelcu, Roxana, Teodora Nedelcu, Iulia, Hodorogea, Anastasia, Balaban, Mihaela, Brinzea, Alice, Nichita, Luciana, Gabriela Popp, Cristiana, Andrada Zurac, Sabina, and Theodor Andrei, Razvan

Subjects
HIDRADENITIS suppurativa, PSORIATIC arthritis, PYODERMA gangrenosum, ACNE, NLRP3 protein, DISEASES, IMMUNE system
Abstract

Suppurative hidradenitis and pyoderma gangrenosum are rare disorders that can be seen isolated or even more rare, as part of different autoinflammatory syndromes: Pyoderma gangrenosum, acne, and hidradenitis suppurativa (PASH), pyoderma gangrenosum, acne, pyogenic arthritis, and hidradenitis suppurativa (PAPASH) or psoriatic arthritis, pyoderma gangrenosum, acne, and hidradenitis suppurativa (PsAPASH). Although they have different clinical features, suppurative hidradenitis and pyoderma gangrenosum seem to share similar pathogenic pathways involving a dysregulated innate immune system, with neutrophilic inflammation, mediated by IL-1β, controlled by NALP3 inflammasome pathway. We report a case of a 53-year-old male patient previously diagnosed with HS in inguinal-scrotal area that developed rapidly after a traumatic injury on his left anterior calf, a painful inflammatory plaque with pustules on the surface that rapidly progressed (24-48 h) to form ulcers. The lesions ended up healing with a large scarring plaque with cribriform openings, multiple fibrous bridges, open comedones, and double-ended pseudo-comedones. Although the clinical aspect at presentation together with the aspect on the first biopsy were suggestive for pyoderma gangrenosum, the healing aspect is more commonly seen in suppurative hidradenitis. Commonly seen in acne, in the healing phase of suppurative hidradenitis but more rarely in pyoderma gangrenosum, the formation of comedones seem to be a complex process and raise the question if these entities represent in our patient an association, an overlap or the spectrum of the same disease. [ABSTRACT FROM AUTHOR]

Published
2020
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