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1. Magnetic-field-driven targeting of exosomes modulates immune and metabolic changes in dystrophic muscle

Author

Villa, C, Secchi, V, Macchi, M, Tripodi, L, Trombetta, E, Zambroni, D, Padelli, F, Mauri, M, Molinaro, M, Oddone, R, Farini, A, De Palma, A, Varela Pinzon, L, Santarelli, F, Simonutti, R, Mauri, P, Porretti, L, Campione, M, Aquino, D, Monguzzi, A, Torrente, Y, Villa, Chiara, Secchi, Valeria, Macchi, Mirco, Tripodi, Luana, Trombetta, Elena, Zambroni, Desiree, Padelli, Francesco, Mauri, Michele, Molinaro, Monica, Oddone, Rebecca, Farini, Andrea, De Palma, Antonella, Varela Pinzon, Laura, Santarelli, Federica, Simonutti, Roberto, Mauri, PierLuigi, Porretti, Laura, Campione, Marcello, Aquino, Domenico, Monguzzi, Angelo, Torrente, Yvan, Villa, C, Secchi, V, Macchi, M, Tripodi, L, Trombetta, E, Zambroni, D, Padelli, F, Mauri, M, Molinaro, M, Oddone, R, Farini, A, De Palma, A, Varela Pinzon, L, Santarelli, F, Simonutti, R, Mauri, P, Porretti, L, Campione, M, Aquino, D, Monguzzi, A, Torrente, Y, Villa, Chiara, Secchi, Valeria, Macchi, Mirco, Tripodi, Luana, Trombetta, Elena, Zambroni, Desiree, Padelli, Francesco, Mauri, Michele, Molinaro, Monica, Oddone, Rebecca, Farini, Andrea, De Palma, Antonella, Varela Pinzon, Laura, Santarelli, Federica, Simonutti, Roberto, Mauri, PierLuigi, Porretti, Laura, Campione, Marcello, Aquino, Domenico, Monguzzi, Angelo, and Torrente, Yvan

Abstract

Exosomes are promising therapeutics for tissue repair and regeneration to induce and guide appropriate immune responses in dystrophic pathologies. However, manipulating exosomes to control their biodistribution and targeting them in vivo to achieve adequate therapeutic benefits still poses a major challenge. Here we overcome this limitation by developing an externally controlled delivery system for primed annexin A1 myo-exosomes (Exomyo). Effective nanocarriers are realized by immobilizing the Exomyo onto ferromagnetic nanotubes to achieve controlled delivery and localization of Exomyo to skeletal muscles by systemic injection using an external magnetic field. Quantitative muscle-level analyses revealed that macrophages dominate the uptake of Exomyo from these ferromagnetic nanotubes in vivo to synergistically promote beneficial muscle responses in a murine animal model of Duchenne muscular dystrophy. Our findings provide insights into the development of exosome-based therapies for muscle diseases and, in general, highlight the formulation of effective functional nanocarriers aimed at optimizing exosome biodistribution

Published
2024

2. Impact of SARS-CoV-2 infection on the recovery of peripheral blood mononuclear cells by density gradient

Author

Manunta, M, Lamorte, G, Ferrari, F, Trombetta, E, Tirone, M, Bianco, C, Cattaneo, A, Santoro, L, Baselli, G, Brasca, M, Ostadreza, M, Erba, E, Gori, A, Bandera, A, Porretti, L, Valenti, L, Prati, D, Manunta M. D. I., Lamorte G., Ferrari F., Trombetta E., Tirone M., Bianco C., Cattaneo A., Santoro L., Baselli G., Brasca M., Ostadreza M., Erba E., Gori A., Bandera A., Porretti L., Valenti L. V. C., Prati D., Manunta, M, Lamorte, G, Ferrari, F, Trombetta, E, Tirone, M, Bianco, C, Cattaneo, A, Santoro, L, Baselli, G, Brasca, M, Ostadreza, M, Erba, E, Gori, A, Bandera, A, Porretti, L, Valenti, L, Prati, D, Manunta M. D. I., Lamorte G., Ferrari F., Trombetta E., Tirone M., Bianco C., Cattaneo A., Santoro L., Baselli G., Brasca M., Ostadreza M., Erba E., Gori A., Bandera A., Porretti L., Valenti L. V. C., and Prati D.

Abstract

SARS-CoV-2 virus infection is responsible for coronavirus disease (COVID-19), which is characterised by a hyperinflammatory response that plays a major role in determining the respiratory and immune-mediated complications of this condition. While isolating peripheral blood mononuclear cells (PBMCs) from whole blood of COVID-19 patients by density gradient centrifugation, we noticed some changes in the floating properties and in the sedimentation of the cells on density medium. Investigating this further, we found that in early phase COVID-19 patients, characterised by reduced circulating lymphocytes and monocytes, the PBMC fraction contained surprisingly high levels of neutrophils. Furthermore, the neutrophil population exhibited alterations in the cell size and in the internal complexity, consistent with the presence of low density neutrophils (LDNs) and immature forms, which may explain the shift seen in the floating abilities and that may be predictive of the severity of the disease. The percentage of this subset of neutrophils found in the PBMC band was rather spread (35.4 +/- 27.2%, with a median 28.8% and IQR 11.6-56.1, Welch's t-test early phase COVID-19 versus blood donor healthy controls P<0.0001). Results confirm the presence of an increased number of LDNs in patients with early stage COVID-19, which correlates with disease severity and may be recovered by centrifugation on a density gradient together with PBMCs.

Published
2021

4. Tumor infiltrating iNKT cells sustain neutrophil pro-tumorigenic functions influencing disease progression in human colorectal cancer

Author

Lattanzi, Georgia, Lattanzi, G, Strati, F, Díaz-Basabe, A, Perillo, F, Amoroso, C, Protti, G, Giuffrè, M, Baldari, L, Cassinotti, E, Ghidini, M, Galassi, B, Lopez, G, Noviello, D, Porretti, L, Trombetta, E, Mazzarella, L, Iezzi, G, Nicassio, F, Granucci, F, Caprioli, F, Facciotti, F, Lattanzi, Georgia, Strati, Francesco, Díaz-Basabe, Angélica, Perillo, Federica, Amoroso, Chiara, Protti, Giulia, Giuffrè, Maria Rita, Baldari, Ludovica, Cassinotti, Elisa, Ghidini, Michele, Galassi, Barbara, Lopez, Gianluca, Noviello, Daniele, Porretti, Laura, Trombetta, Elena, Mazzarella, Luca, Iezzi, Giandomenica, Nicassio, Francesco, Granucci, Francesca, Caprioli, Flavio, Facciotti, Federica, Lattanzi, Georgia, Lattanzi, G, Strati, F, Díaz-Basabe, A, Perillo, F, Amoroso, C, Protti, G, Giuffrè, M, Baldari, L, Cassinotti, E, Ghidini, M, Galassi, B, Lopez, G, Noviello, D, Porretti, L, Trombetta, E, Mazzarella, L, Iezzi, G, Nicassio, F, Granucci, F, Caprioli, F, Facciotti, F, Lattanzi, Georgia, Strati, Francesco, Díaz-Basabe, Angélica, Perillo, Federica, Amoroso, Chiara, Protti, Giulia, Giuffrè, Maria Rita, Baldari, Ludovica, Cassinotti, Elisa, Ghidini, Michele, Galassi, Barbara, Lopez, Gianluca, Noviello, Daniele, Porretti, Laura, Trombetta, Elena, Mazzarella, Luca, Iezzi, Giandomenica, Nicassio, Francesco, Granucci, Francesca, Caprioli, Flavio, and Facciotti, Federica

Published
2022

5. IL10 secretion endows intestinal human iNKT cells with regulatory functions towards pathogenic T lymphocytes

Author

Burrello, C, Strati, F, Lattanzi, G, Diaz-Basabe, A, Mileti, E, Giuffrè, M, Lopez, G, Cribiù, F, Trombetta, E, Kallikourdis, M, Cremonesi, M, Conforti, F, Botti, F, Porretti, L, Rescigno, M, Vecchi, M, Fantini, M, Caprioli, F, Facciotti, F, Burrello, Claudia, Strati, Francesco, Lattanzi, Georgia, Diaz-Basabe, Angelica, Mileti, Erika, Giuffrè, Maria Rita, Lopez, Gianluca, Cribiù, Fulvia Milena, Trombetta, Elena, Kallikourdis, Marinos, Cremonesi, Marco, Conforti, Francesco, Botti, Fiorenzo, Porretti, Laura, Rescigno, Maria, Vecchi, Maurizio, Fantini, Massimo C, Caprioli, Flavio, Facciotti, Federica, Burrello, C, Strati, F, Lattanzi, G, Diaz-Basabe, A, Mileti, E, Giuffrè, M, Lopez, G, Cribiù, F, Trombetta, E, Kallikourdis, M, Cremonesi, M, Conforti, F, Botti, F, Porretti, L, Rescigno, M, Vecchi, M, Fantini, M, Caprioli, F, Facciotti, F, Burrello, Claudia, Strati, Francesco, Lattanzi, Georgia, Diaz-Basabe, Angelica, Mileti, Erika, Giuffrè, Maria Rita, Lopez, Gianluca, Cribiù, Fulvia Milena, Trombetta, Elena, Kallikourdis, Marinos, Cremonesi, Marco, Conforti, Francesco, Botti, Fiorenzo, Porretti, Laura, Rescigno, Maria, Vecchi, Maurizio, Fantini, Massimo C, Caprioli, Flavio, and Facciotti, Federica

Abstract

BACKGROUND AND AIMS: Invariant natural killer T [iNKT] cells perform pleiotropic functions in different tissues by secreting a vast array of pro-inflammatory and cytotoxic molecules. However, the presence and function of human intestinal iNKT cells capable of secreting immunomodulatory molecules such as IL-10 has never been reported so far. Here we describe for the first time the presence of IL10-producing iNKT cells [NKT10 cells] in the intestinal lamina propria of healthy individuals and of Crohn's disease [CD] patients. METHODS: Frequency and phenotype of NKT10 cells were analysed ex vivo from intestinal specimens of Crohn's disease [n = 17] and controls [n = 7]. Stable CD-derived intestinal NKT10 cell lines were used to perform in vitro suppression assays and co-cultures with patient-derived mucosa-associated microbiota. Experimental colitis models were performed by adoptive cell transfer of splenic naïve CD4+ T cells in the presence or absence of IL10-sufficient or -deficient iNKT cells. In vivo induction of NKT10 cells was performed by administration of short chain fatty acids [SCFA] by oral gavage. RESULTS: Patient-derived intestinal NKT10 cells demonstrated suppressive capabilities towards pathogenic CD4+ T cells. The presence of increased proportions of mucosal NKT10 cells associated with better clinical outcomes in CD patients. Moreover, an intestinal microbial community enriched in SCFA-producing bacteria sustained the production of IL10 by iNKT cells. Finally, IL10-deficient iNKT cells failed to control the pathogenic activity of adoptively transferred CD4+ T cells in an experimental colitis model. CONCLUSIONS: These results describe an unprecedentd IL10-mediated immunoregulatory role of intestinal iNKT cells in controlling the pathogenic functions of mucosal T helper subsets and in maintaining the intestinal immune homeostasis.

Published
2022

6. Mucosa-associated microbiota drives pathogenic functions in IBD-derived intestinal iNKT cells

Author

Burrello, C, Pellegrino, G, Giuffrè, M, Lovati, G, Magagna, I, Bertocchi, A, Cribiù, F, Boggio, F, Botti, F, Trombetta, E, Porretti, L, Di Sabatino, A, Vecchi, M, Rescigno, M, Caprioli, F, Facciotti, F, Burrello C, Pellegrino G, Giuffrè MR, Lovati G, Magagna I, Bertocchi A, Cribiù FM, Boggio F, Botti F, Trombetta E, Porretti L, Di Sabatino A, Vecchi M, Rescigno M, Caprioli F, Facciotti F, Burrello, C, Pellegrino, G, Giuffrè, M, Lovati, G, Magagna, I, Bertocchi, A, Cribiù, F, Boggio, F, Botti, F, Trombetta, E, Porretti, L, Di Sabatino, A, Vecchi, M, Rescigno, M, Caprioli, F, Facciotti, F, Burrello C, Pellegrino G, Giuffrè MR, Lovati G, Magagna I, Bertocchi A, Cribiù FM, Boggio F, Botti F, Trombetta E, Porretti L, Di Sabatino A, Vecchi M, Rescigno M, Caprioli F, and Facciotti F

Abstract

Inflammatory bowel disease (IBD) pathogenesis has been linked to the aberrant activation of the Gut-associated lymphoid tissues against components of the intestinal microbiota. Although the contribution of CD4+ T helper cells to inflammatory processes is being increasingly acknowledged, the functional engagement of human invariant natural killer T (iNKT) cells is still poorly defined. Here, we evaluated the functional characteristics of intestinal iNKT cells during IBD pathogenesis and to exploit the role of mucosa-associated microbiota recognition in triggering iNKT cells’ pro-inflammatory responses in vivo. Lamina propria iNKT cells, isolated from surgical specimens of active ulcerative colitis and Crohn’s disease patients and non-IBD donors, were phenotypically and functionally analyzed ex vivo, and stable cell lines and clones were generated for in vitro functional assays. iNKT cells expressing a pro-inflammatory cytokine profile were enriched in the lamina propria of IBD patients, and their exposure to the mucosa-associated microbiota drives pro-inflammatory activation, inducing direct pathogenic activities against the epithelial barrier integrity. These observations suggest that iNKT cell pro-inflammatory functions may contribute to the fuelling of intestinal inflammation in IBD patients.

Published
2019

8. Functionalized Scintillating Nanotubes for Simultaneous Radio- and Photodynamic Therapy of Cancer

Author

Villa, I, Villa, C, Crapanzano, R, Secchi, V, Tawfilas, M, Trombetta, E, Porretti, L, Brambilla, A, Campione, M, Torrente, Y, Vedda, A, Monguzzi, A, Villa, Irene, Villa, Chiara, Crapanzano, Roberta, Secchi, Valeria, Tawfilas, Massimo, Trombetta, Elena, Porretti, Laura, Brambilla, Andrea, Campione, Marcello, Torrente, Yvan, Vedda, Anna, Monguzzi, Angelo, Villa, I, Villa, C, Crapanzano, R, Secchi, V, Tawfilas, M, Trombetta, E, Porretti, L, Brambilla, A, Campione, M, Torrente, Y, Vedda, A, Monguzzi, A, Villa, Irene, Villa, Chiara, Crapanzano, Roberta, Secchi, Valeria, Tawfilas, Massimo, Trombetta, Elena, Porretti, Laura, Brambilla, Andrea, Campione, Marcello, Torrente, Yvan, Vedda, Anna, and Monguzzi, Angelo

Abstract

As a model radio-photodynamic therapy (RPDT) agent, we developed a multicomponent nanomaterial by anchoring conjugated chromophores on the surface of scintillating chrysotile nanotubes. Its ultimate composition makes the system a scintillation-activated photosensitizer for the singlet oxygen production. This nanomaterial shows a remarkable ability to enhance the production of singlet oxygen in an aqueous environment, under X-ray irradiation, boosting its production by almost 1 order of magnitude. Its efficiency as a coadjutant for radiotherapy has been tested in vitro, showing a striking efficacy in enhancing both the prompt cytotoxicity of the ionizing radiation and the long-term cytotoxicity given by radiation-activated apoptosis. Notably, the beneficial activity of the RPDT agent is prominent at low levels of delivered doses comparable to the one employed in clinical treatments. This opens the possibility of effectively reducing the therapy exposure and consequently undesired collateral effects due to prolonged exposure of patients to high-energy radiation.

Published
2021

11. Excellent long-term virological and clinical response in HDV compensated cirrhotics treated with high dose Bulevirtide beyond 2.5 years: A case series

Author

Loglio, A., primary, Ferenci, P., additional, Renteria, SC. Uceda, additional, Holzmann, H., additional, Borghi, M., additional, Perbellini, R., additional, Rimondi, A., additional, Trombetta, E., additional, Giovanelli, S., additional, Porretti, L., additional, Prati, D., additional, Ceriotti, F., additional, and Lampertico, P., additional

Published
2021
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14. Measures to prevent transfusion-related acute lung injury (TRALI)

Author

Reesink, H. W., Lee, J., Keller, A., Dennington, P., Pink, J., Holdsworth, R., Schennach, H., Goldman, M., Petraszko, T., Sun, J., Meng, Y., Qian, K., Rehacek, V., Turek, P., Krusius, T., Juvonen, E., Tiberghien, P., Legrand, D., Semana, G., Muller, J. Y., Bux, J., Reil, A., Lin, C. K., Daly, H., McSweeney, E., Porretti, L., Greppi, N., Rebulla, P., Okazaki, H., Sánchez-Guerrero, S. A., Baptista-González, H. A., Martínez-Murillo, C., Guerra-Márquez, A., Rodriguez-Moyado, H., Middelburg, R. A., Wiersum-Osselton, J. C., Brand, A., van Tilburg, C., Dinesh, D., Dagger, J., Dunn, P., Brojer, E., Letowska, M., Maslanka, K., Lachert, E., Uhrynowska, M., Zhiburt, E., Palfi, M., Berlin, G., Frey, B. M., Rovira, Puig L., Muñiz-Diaz, E., Castro, E., Chapman, C., Green, A., Massey, E., Win, N., Williamson, L., Silliman, C. C., Chaffin, D. J., Ambruso, D. R., Blumberg, N., Tomasulo, P., Land, K. J., Norris, P. J., Illoh, O. C., Davey, R. J., Benjamin, R. J., Eder, A. F., McLaughlin, L., Kleinman, S., and Panzer, S.

Published
2012
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18. Safety and efficacy of up to 76 weeks 10 mg/day (high dose) bulevirtide monotherapy in compensated cirrhotics with delta hepatitis

Author

Loglio, A., primary, Ferenci, P., additional, Schlund, F., additional, Tham, C.Y.L., additional, van Bömmel, F., additional, Renteria, SC. Uceda, additional, Borghi, M., additional, Holzmann, H., additional, Perbellini, R., additional, Trombetta, E., additional, Giovanelli, S., additional, Porretti, L., additional, Prati, D., additional, Ceriotti, F., additional, Lunghi, G., additional, Bertoletti, A., additional, Urban, S., additional, and Lampertico, P., additional

Published
2020
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21. Skin-derived stem cells transplanted into resorbable guides provide functional nerve regeneration after sciatic nerve resection

Author

Marchesi, C., Pluderi, M., Colleoni, F., Belicchi, M., Meregalli, M., Farini, A., Parolini, D., Draghi, L., Fruguglietti, M. E., Gavina, M., Porretti, L., Cattaneo, A., Battistelli, M., Prelle, A., Moggio, M., Borsa, S., Bello, L., Spagnoli, D., Gaini, S. M., Tanzi, M. C., Bresolin, N., Grimoldi, N., and Torrente, Y.

Published
2007
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25. Effectiveness, safety and T-cell activation profiles of long-term Myrcludex B treatment in two patients with HDV related compensated cirrhosis

Author

Loglio, A., primary, Alexandrov, A., additional, Renteria, S.C. Uceda, additional, Tham, C.Y.L., additional, Greco, L., additional, Borghi, M., additional, Perbellini, R., additional, Trombetta, E., additional, Giovanelli, S., additional, Porretti, L., additional, Lecchi, L., additional, Prati, D., additional, Ceriotti, F., additional, Lunghi, G., additional, Bertoletti, A., additional, and Lampertico, P., additional

Published
2019
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28. Autoimmune neutropenia of childhood secondary to other autoimmune disorders: Data from the Italian neutropenia registry

Author

Farruggia, P, Puccio, G, Fioredda, F, Lanza, T, Porretti, L, Ramenghi, U, Barone, A, Bonanomi, S, Finocchi, A, Ghilardi, R, Ladogana, S, Marra, N, Martire, B, Notarangelo, Ld, Onofrillo, D, Pillon, M, Russo, G, Lo Valvo, L, Serafinelli, J, Tucci, F, Zunica, F, Verzegnassi, F, and Dufour, C

Subjects
Male, Neutropenia, Infant, Newborn, Immunoglobulins, Intravenous, Immunoglobulins, Infant, Diseases, Infant, Premature, Diseases, Hematology, Newborn, Autoimmune Diseases, Child, Disease Susceptibility, Female, Humans, Immunosuppressive Agents, Infant, Premature, Italy, Prevalence, Registries, Settore MED/38, Intravenous, Premature
Published
2017

29. AB0178 Phenotyping of natural killer (NK) receptors on NK and NKT-LIKE cells discloses defective immune-regulatory capability in patients with systemic sclerosis

Author

Cossu, M, primary, Beretta, L, additional, Trombetta, E, additional, Bijnen, STA van, additional, Rossato, M, additional, Bon, L van, additional, Kroef, M van der, additional, Chouri, EC, additional, Wichers, CGK, additional, Vazirpanah, N, additional, Vonk, MC, additional, Porretti, L, additional, Preijers, F, additional, Dolstra, H, additional, and Radstake, TRDJ, additional

Published
2017
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30. A miRNA signature in human cord blood stem and progenitor cells as potential biomarker of specific acute myeloid leukemia subtypes

Author

Cattaneo, M, Pelosi, E, Castelli, G, Cerio, A, D'Angio, A, Porretti, L, Rebulla, P, Pavesi, L, Russo, G, Giordano, A, Turri, J, Cicconi, L, LO COCO, F, Testa, U, and Biunno, I

Subjects
Myeloid, Biomarkers, Tumor, Cell Differentiation, Computational Biology, Fetal Blood, Hematopoietic Stem Cells, Humans, Leukemia, Myeloid, Acute, MicroRNAs, Oligonucleotide Array Sequence Analysis, Real-Time Polymerase Chain Reaction, Transcriptome, Clinical Biochemistry, Cell Biology, Physiology, Medicine (all), Tumor, Leukemia, Acute, Settore MED/15 - Malattie del Sangue, Biomarkers
Abstract

MicroRNAs (miRNAs) are important regulators of several cellular processes. During hematopoiesis, specific expression signatures have been reported in different blood cell lineages and stages of hematopoietic stem cell (HSC) differentiation. Here we explored the expression of miRNAs in umbilical cord blood stem (HSC) and progenitor cells (HPC) and compared it to unilineage granulocyte and granulo-monocyte differentiation as well as to primary blasts from patients with acute myeloid leukemia (AML). CD34 + CD38- ad CD34 + CD38 + cells were profiled using a global array consisting of about 2000 miRNAs. An approach combining bioinformatic prediction of miRNA targets with mRNA expression profiling was used to search for putative biologically enriched functions and networks. At least 15 miRNAs to be differentially expressed between HSC and HPC cell population, a cluster of 7 miRNAs are located in the q32 region of human chromosome 14 (miR-377-3p, -136-5p, 376a-3p, 495-3p, 654-3p, 376c-3p and 381-3p) whose expression decreased during the early stages of normal myelopoiesis but were markedly increased in a small set of AML. Interestingly, miR-4739 and -4516, two novel microRNA whose function and targets are presently unknown, showed specific and peculiar expression profile during the hematopoietic stem cells differentiation into unilineages and resulted strongly upregulated in almost all AML subsets. miR-181, -126-5p, -29b-3p and -22-3p resulted dis-regulated in specific leukemias phenotypes. This study provides the first evidence of a miRNA signature in human cord blood stem and progenitor cells with a potential role in hematopoietic stemness properties and possibly in leukemogenesis of specific AML subtypes.

Published
2015

31. AUTOIMMUNE NEUTROPENIA OF INFANCY: DATA FROM THE ITALIAN NEUTROPENIA REGISTRY

Author

Farruggia, P, Fioredda, F, Puccio, G, Porretti, L, Lanza, T, Ferro, F, Barone, A, Bonanomi, S, Davitto, M, Ghilardi, R, Ladogana, S, Mandaglio, R, Marra, N, Martire, B, Notarangelo, Ld, Onofrillo, D, Pillon, M, Ramenghi, U, Robustelli, G, Russo, G, Tucci, F, Macaluso, A, and Dufour, C

Published
2015

34. A miRNA Signature in Human Cord Blood Stem and Progenitor Cells as Potential Biomarker of Specific Acute Myeloid Leukemia Subtypes

Author

Cattaneo, M., primary, Pelosi, E., additional, Castelli, G., additional, Cerio, A.M., additional, D′angiò, A., additional, Porretti, L., additional, Rebulla, P., additional, Pavesi, L., additional, Russo, G., additional, Giordano, A., additional, Turri, J., additional, Cicconi, L., additional, Lo-Coco, F., additional, Testa, U., additional, and Biunno, Ida, additional

Published
2015
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37. Gene expression analysis of cord blood stem cells

Author

Giorgetti, A, Agnelli, L, Mezzelani, A, Porretti, L, Bicciato, Silvio, Mattioli, M, Battaglia, C, Neri, A, Rebulla, P, and Lazzari, L.

Subjects
stem cells, Gene expression, bioinformatics
Published
2004

39. Measures to prevent transfusion-related acute lung injury (TRALI)

Author

Reesink, H W, Lee, J, Keller, A, Dennington, P, Pink, J, Holdsworth, R, Schennach, H, Goldman, M, Petraszko, T, Sun, J, Meng, Y, Qian, K, Rehacek, V, Turek, P, Krusius, T, Juvonen, E, Tiberghien, P, Legrand, D, Semana, G, Muller, J Y, Bux, J, Reil, A, Lin, C K, Daly, H, McSweeney, E, Porretti, L, Greppi, N, Rebulla, P, Okazaki, H, Sanchez-Guerrero, S A, Baptista-Gonzalez, H A, Martinez-Murillo, C, Guerra-Marquez, A, Rodriguez-Moyado, H, Middelburg, R A, Wiersum-Osselton, J C, Brand, A, van Tilburg, C, Dinesh, D, Dagger, J, Dunn, P, Brojer, E, Letowska, M, Maslanka, K, Lachert, E, Uhrynowska, M, Zhiburt, E, Palfi, Miodrag, Berlin, Gösta, Frey, B M, Puig Rovira, L, Muniz-Diaz, E, Chapman, C, Green, A, Massey, E, Win, N, Williamson, L, Silliman, C C, Chaffin, D J, Tomasulo, P, Land, K J, Norris, P J, Illoh, O C, Davey, R J, Benjamin, R J, Eder, A F, McLaughlin, L, Kleinman, S, Reesink, H W, Lee, J, Keller, A, Dennington, P, Pink, J, Holdsworth, R, Schennach, H, Goldman, M, Petraszko, T, Sun, J, Meng, Y, Qian, K, Rehacek, V, Turek, P, Krusius, T, Juvonen, E, Tiberghien, P, Legrand, D, Semana, G, Muller, J Y, Bux, J, Reil, A, Lin, C K, Daly, H, McSweeney, E, Porretti, L, Greppi, N, Rebulla, P, Okazaki, H, Sanchez-Guerrero, S A, Baptista-Gonzalez, H A, Martinez-Murillo, C, Guerra-Marquez, A, Rodriguez-Moyado, H, Middelburg, R A, Wiersum-Osselton, J C, Brand, A, van Tilburg, C, Dinesh, D, Dagger, J, Dunn, P, Brojer, E, Letowska, M, Maslanka, K, Lachert, E, Uhrynowska, M, Zhiburt, E, Palfi, Miodrag, Berlin, Gösta, Frey, B M, Puig Rovira, L, Muniz-Diaz, E, Chapman, C, Green, A, Massey, E, Win, N, Williamson, L, Silliman, C C, Chaffin, D J, Tomasulo, P, Land, K J, Norris, P J, Illoh, O C, Davey, R J, Benjamin, R J, Eder, A F, McLaughlin, L, and Kleinman, S

Abstract

n/a

Published
2012
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40. Therapeutic application of stem cells in gastroenterology: an up-date

Author

Burra, P, Bizzaro, D, Ciccocioppo, R, Marra, F, Piscaglia, Ac, Porretti, L, Gasbarrini, Antonio, Russo, Fp, Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Burra, P, Bizzaro, D, Ciccocioppo, R, Marra, F, Piscaglia, Ac, Porretti, L, Gasbarrini, Antonio, Russo, Fp, and Gasbarrini, Antonio (ORCID:0000-0002-7278-4823)

Abstract

Adult stem cells represent the self-renewing progenitors of numerous body tissues, and they are currently classified according to their origin and differentiation ability. In recent years, the research on stem cells has expanded enormously and holds therapeutic promises for many patients suffering from currently disabling diseases. This paper focuses on the possible use of stem cells in the two main clinical settings in gastroenterology, i.e., hepatic and intestinal diseases, which have a strong impact on public health worldwide. Despite encouraging results obtained in both regenerative medicine and immune-mediated conditions, further studies are needed to fully understand the biology of stem cells and carefully assess their putative oncogenic properties. Moreover, the research on stem cells arouses fervent ethical, social and political debate. The Italian Society of Gastroenterology sponsored a workshop on stem cells held in Verona during the XVI Congress of the Federation of Italian Societies of Digestive Diseases (March 6-9, 2010). Here, we report on the issues discussed, including liver and intestinal diseases that may benefit from stem cell therapy, the biology of hepatic and intestinal tissue repair, and stem cell usage in clinical trials.

Published
2011

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