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13 results on '"Portela Catani, João Paulo"'

1. The antigenic landscape of human influenza N2 neuraminidases from 2009 until 2017.

Author

Portela Catani, João Paulo, Smet, Anouk, Ysenbaert, Tine, Vuylsteke, Marnik, Bottu, Guy, Mathys, Janick, Botzki, Alexander, Cortes-Garcia, Guadalupe, Strugnell, Tod, Gomila, Raul, Hamberger, John, Catalan, John, Ustyugova, Irina V., Farrell, Timothy, Stegalkina, Svetlana, Ray, Satyajit, LaRue, Lauren, Saelens, Xavier, and Vogel, Thorsten U.

Subjects
*INFLUENZA, *FLU vaccine efficacy, *SEASONAL influenza, *IMMUNE serums, *INFLUENZA A virus, H3N2 subtype, *NEURAMINIDASE
Abstract

Human H3N2 influenza viruses are subject to rapid antigenic evolution which translates into frequent updates of the composition of seasonal influenza vaccines. Despite these updates, the effectiveness of influenza vaccines against H3N2-associated disease is suboptimal. Seasonal influenza vaccines primarily induce hemagglutinin-specific antibody responses. However, antibodies directed against influenza neuraminidase (NA) also contribute to protection. Here, we analysed the antigenic diversity of a panel of N2 NAs derived from human H3N2 viruses that circulated between 2009 and 2017. The antigenic breadth of these NAs was determined based on the NA inhibition (NAI) of a broad panel of ferret and mouse immune sera that were raised by infection and recombinant N2 NA immunisation. This assessment allowed us to distinguish at least four antigenic groups in the N2 NAs derived from human H3N2 viruses that circulated between 2009 and 2017. Computational analysis further revealed that the amino acid residues in N2 NA that have a major impact on susceptibility to NAI by immune sera are in proximity of the catalytic site. Finally, a machine learning method was developed that allowed to accurately predict the impact of mutations that are present in our N2 NA panel on NAI. These findings have important implications for the renewed interest to develop improved influenza vaccines based on the inclusion of a protective NA antigen formulation. [ABSTRACT FROM AUTHOR]

Published
2024
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2. The antigenic landscape of human influenza N2 neuraminidases from 2009 until 2017

Author

Portela Catani, João Paulo, primary, Smet, Anouk, additional, Ysenbaert, Tine, additional, Vuylsteke, Marnik, additional, Bottu, Guy, additional, Mathys, Janick, additional, Botzki, Alexander, additional, Cortes-Garcia, Guadalupe, additional, Strugnell, Tod, additional, Gomila, Raul, additional, Hamberger, John, additional, Catalan, John, additional, Ustyugova, Irina V., additional, Farrell, Timothy, additional, Stegalkina, Svetlana, additional, Ray, Satyajit, additional, LaRue, Lauren, additional, Saelens, Xavier, additional, and Vogel, Thorsten U., additional

Published
2023
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3. Supplementary Figures 1 - 7 from CCL2/CCR2-Dependent Recruitment of Functional Antigen-Presenting Cells into Tumors upon Chemotherapy

Author

Ma, Yuting, primary, Mattarollo, Stephen R., primary, Adjemian, Sandy, primary, Yang, Heng, primary, Aymeric, Laetitia, primary, Hannani, Dalil, primary, Portela Catani, João Paulo, primary, Duret, Helene, primary, Teng, Michele W.L., primary, Kepp, Oliver, primary, Wang, Yidan, primary, Sistigu, Antonella, primary, Schultze, Joachim L., primary, Stoll, Gautier, primary, Galluzzi, Lorenzo, primary, Zitvogel, Laurence, primary, Smyth, Mark J., primary, and Kroemer, Guido, primary

Published
2023
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4. Data from CCL2/CCR2-Dependent Recruitment of Functional Antigen-Presenting Cells into Tumors upon Chemotherapy

Author

Ma, Yuting, primary, Mattarollo, Stephen R., primary, Adjemian, Sandy, primary, Yang, Heng, primary, Aymeric, Laetitia, primary, Hannani, Dalil, primary, Portela Catani, João Paulo, primary, Duret, Helene, primary, Teng, Michele W.L., primary, Kepp, Oliver, primary, Wang, Yidan, primary, Sistigu, Antonella, primary, Schultze, Joachim L., primary, Stoll, Gautier, primary, Galluzzi, Lorenzo, primary, Zitvogel, Laurence, primary, Smyth, Mark J., primary, and Kroemer, Guido, primary

Published
2023
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5. Supplementary Figure Legend from CCL2/CCR2-Dependent Recruitment of Functional Antigen-Presenting Cells into Tumors upon Chemotherapy

Author

Ma, Yuting, primary, Mattarollo, Stephen R., primary, Adjemian, Sandy, primary, Yang, Heng, primary, Aymeric, Laetitia, primary, Hannani, Dalil, primary, Portela Catani, João Paulo, primary, Duret, Helene, primary, Teng, Michele W.L., primary, Kepp, Oliver, primary, Wang, Yidan, primary, Sistigu, Antonella, primary, Schultze, Joachim L., primary, Stoll, Gautier, primary, Galluzzi, Lorenzo, primary, Zitvogel, Laurence, primary, Smyth, Mark J., primary, and Kroemer, Guido, primary

Published
2023
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9. Anticancer Chemotherapy-Induced Intratumoral Recruitment and Differentiation of Antigen-Presenting Cells

Author

Ma, Yuting, Adjemian, Sandy, Mattarollo, Stephen R., Yamazaki, Takahiro, Aymeric, Laetitia, Yang, Heng, Portela Catani, João Paulo, Hannani, Dalil, Duret, Helene, Steegh, Kim, Martins, Isabelle, Schlemmer, Frederic, Michaud, Mickaël, Kepp, Oliver, Sukkurwala, Abdul Qader, Menger, Laurie, Vacchelli, Erika, Droin, Nathalie, Galluzzi, Lorenzo, Krzysiek, Roman, Gordon, Siamon, Taylor, Philip R., Van Endert, Peter, Solary, Eric, Smyth, Mark J., Zitvogel, Laurence, and Kroemer, Guido

Published
2013
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10. Immunogenicity and Protection Efficacy of a Naked Self-Replicating mRNA-Based Zika Virus Vaccine

Author

Zhong, Zifu, primary, Portela Catani, João Paulo, additional, Mc Cafferty, Séan, additional, Couck, Liesbeth, additional, Van Den Broeck, Wim, additional, Gorlé, Nina, additional, Vandenbroucke, Roosmarijn E., additional, Devriendt, Bert, additional, Ulbert, Sebastian, additional, Cnops, Lieselotte, additional, Michels, Johan, additional, Ariën, Kevin K., additional, and Sanders, Niek N., additional

Published
2019
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11. CCL2/CCR2-Dependent Recruitment of Functional Antigen-Presenting Cells into Tumors upon Chemotherapy

Author

Ma, Yuting, primary, Mattarollo, Stephen R., additional, Adjemian, Sandy, additional, Yang, Heng, additional, Aymeric, Laetitia, additional, Hannani, Dalil, additional, Portela Catani, João Paulo, additional, Duret, Helene, additional, Teng, Michele W.L., additional, Kepp, Oliver, additional, Wang, Yidan, additional, Sistigu, Antonella, additional, Schultze, Joachim L., additional, Stoll, Gautier, additional, Galluzzi, Lorenzo, additional, Zitvogel, Laurence, additional, Smyth, Mark J., additional, and Kroemer, Guido, additional

Published
2014
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12. ATP-dependent recruitment, survival and differentiation of dendritic cell precursors in the tumor bed after anticancer chemotherapy.

Author

Yuting Ma, Adjemian, Sandy, Heng Yang, Portela Catani, João Paulo, Hannani, Dalil, Martins, Isabelle, Michaud, Mickaël, Kepp, Oliver, Qader Sukkurwala, Abdul, Vacchelli, Erika, Galluzzi, Lorenzo, Zitvogel, Laurence, and Kroemer, Guido

Subjects
ADENOSINE triphosphate, DENDRITIC cells, CANCER chemotherapy, TUMOR antigens, EXTRACELLULAR enzymes
Abstract

Tumor cells succumb to chemotherapy while releasing ATP. We have found that extracellular ATP attracts dendritic cell (DC) precursors into the tumor bed, facilitates their permanence in the proximity of dying cells and promotes their differentiation into mature DCs endowed with the capacity of presenting tumor-associated antigens. [ABSTRACT FROM AUTHOR]

Published
2013
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13. Corticosteroids and cellulose purification improve, respectively, the in vivotranslation and vaccination efficacy of sa-mRNAs

Author

Zhong, Zifu, McCafferty, Séan, Opsomer, Lisa, Wang, Haixiu, Huysmans, Hanne, De Temmerman, Joyca, Lienenklaus, Stefan, Portela Catani, João Paulo, Combes, Francis, and Sanders, Niek N.

Abstract

Synthetic mRNAs are an appealing platform with multiple biomedical applications ranging from protein replacement therapy to vaccination. In comparison with conventional mRNA, synthetic self-amplifying mRNAs (sa-mRNAs) are gaining increased interest because of their higher and longer-lasting expression. However, sa-mRNAs also elicit an innate immune response, which may complicate their clinical application. Approaches to reduce the innate immunity of sa-mRNAs have not been studied in detail. Here we investigated, in vivo, the effect of several innate immune inhibitors and a novel cellulose-based mRNA purification approach on the type I interferon (IFN) response and the translation and vaccination efficacy of our formerly developed sa-mRNA vaccine against Zika virus. Among the investigated inhibitors, we found that corticosteroids and especially topical application of clobetasol at the sa-mRNA injection site was the most efficient in suppressing the type I IFN response and increasing the translation of sa-mRNA. However, clobetasol prevented formation of antibodies against sa-mRNA-encoded antigens and should therefore be avoided in a vaccination context. Residual dsRNA by-products of the in vitrotranscription reaction are known inducers of immediate type I IFN responses. We additionally demonstrate a drastic reduction of these dsRNA by-products upon cellulose-based purification, reducing the innate immune response and improving sa-mRNA vaccination efficacy.

Published
2021
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