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12 results on '"Porter, Caroline B.M."'

1. Tissue-resident memory and circulating T cells are early responders to pre-surgical cancer immunotherapy

Author

Luoma, Adrienne M., Suo, Shengbao, Wang, Yifan, Gunasti, Lauren, Porter, Caroline B.M., Nabilsi, Nancy, Tadros, Jenny, Ferretti, Andrew P., Liao, Sida, Gurer, Cagan, Chen, Yu-Hui, Criscitiello, Shana, Ricker, Cora A., Dionne, Danielle, Rozenblatt-Rosen, Orit, Uppaluri, Ravindra, Haddad, Robert I., Ashenberg, Orr, Regev, Aviv, Van Allen, Eliezer M., MacBeath, Gavin, Schoenfeld, Jonathan D., and Wucherpfennig, Kai W.

Published
2022
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3. A Distinct Transcriptional Program in Human CAR T Cells Bearing the 4-1BB Signaling Domain Revealed by scRNA-Seq

Author

Boroughs, Angela C., Larson, Rebecca C., Marjanovic, Nemanja D., Gosik, Kirk, Castano, Ana P., Porter, Caroline B.M., Lorrey, Selena J., Ashenberg, Orr, Jerby, Livnat, Hofree, Matan, Smith-Rosario, Gabriela, Morris, Robert, Gould, Joshua, Riley, Lauren S., Berger, Trisha R., Riesenfeld, Samantha J., Rozenblatt-Rosen, Orit, Choi, Bryan D., Regev, Aviv, and Maus, Marcela V.

Published
2020
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4. Emergence of a High-Plasticity Cell State during Lung Cancer Evolution

Author

Marjanovic, Nemanja Despot, Hofree, Matan, Chan, Jason E., Canner, David, Wu, Katherine, Trakala, Marianna, Hartmann, Griffin G., Smith, Olivia C., Kim, Jonathan Y., Evans, Kelly Victoria, Hudson, Anna, Ashenberg, Orr, Porter, Caroline B.M., Bejnood, Alborz, Subramanian, Ayshwarya, Pitter, Kenneth, Yan, Yan, Delorey, Toni, Phillips, Devan R., Shah, Nisargbhai, Chaudhary, Ojasvi, Tsankov, Alexander, Hollmann, Travis, Rekhtman, Natasha, Massion, Pierre P., Poirier, John T., Mazutis, Linas, Li, Ruifang, Lee, Joo-Hyeon, Amon, Angelika, Rudin, Charles M., Jacks, Tyler, Regev, Aviv, and Tammela, Tuomas

Published
2020
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5. Transcriptional Atlas of Intestinal Immune Cells Reveals that Neuropeptide α-CGRP Modulates Group 2 Innate Lymphoid Cell Responses

Author

Xu, Heping, Ding, Jiarui, Porter, Caroline B.M., Wallrapp, Antonia, Tabaka, Marcin, Ma, Sai, Fu, Shujie, Guo, Xuanxuan, Riesenfeld, Samantha J., Su, Chienwen, Dionne, Danielle, Nguyen, Lan T., Lefkovith, Ariel, Ashenberg, Orr, Burkett, Patrick R., Shi, Hai Ning, Rozenblatt-Rosen, Orit, Graham, Daniel B., Kuchroo, Vijay K., Regev, Aviv, and Xavier, Ramnik J.

Published
2019
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6. A spatial cell atlas of neuroblastoma reveals developmental, epigenetic and spatial axis of tumor heterogeneity

Author

Patel, Anand G., primary, Ashenberg, Orr, additional, Collins, Natalie B., additional, Segerstolpe, Åsa, additional, Jiang, Sizun, additional, Slyper, Michal, additional, Huang, Xin, additional, Caraccio, Chiara, additional, Jin, Hongjian, additional, Sheppard, Heather, additional, Xu, Ke, additional, Chang, Ti-Cheng, additional, Orr, Brent A., additional, Shirinifard, Abbas, additional, Chapple, Richard H., additional, Shen, Amber, additional, Clay, Michael R., additional, Tatevossian, Ruth G., additional, Reilly, Colleen, additional, Patel, Jaimin, additional, Lupo, Marybeth, additional, Cline, Cynthia, additional, Dionne, Danielle, additional, Porter, Caroline B.M., additional, Waldman, Julia, additional, Bai, Yunhao, additional, Zhu, Bokai, additional, Barrera, Irving, additional, Murray, Evan, additional, Vigneau, Sébastien, additional, Napolitano, Sara, additional, Wakiro, Isaac, additional, Wu, Jingyi, additional, Grimaldi, Grace, additional, Dellostritto, Laura, additional, Helvie, Karla, additional, Rotem, Asaf, additional, Lako, Ana, additional, Cullen, Nicole, additional, Pfaff, Kathleen L., additional, Karlström, Åsa, additional, Jané-Valbuena, Judit, additional, Todres, Ellen, additional, Thorner, Aaron, additional, Geeleher, Paul, additional, Rodig, Scott J., additional, Zhou, Xin, additional, Stewart, Elizabeth, additional, Johnson, Bruce E., additional, Wu, Gang, additional, Chen, Fei, additional, Yu, Jiyang, additional, Goltsev, Yury, additional, Nolan, Garry P., additional, Rozenblatt-Rosen, Orit, additional, Regev, Aviv, additional, and Dyer, Michael A., additional

Published
2024
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8. A single-nucleus and spatial transcriptomic atlas of the COVID-19 liver reveals topological, functional, and regenerative organ disruption in patients

Author

Pita-Juarez, Yered, primary, Karagkouni, Dimitra, additional, Kalavros, Nikolaos, additional, Melms, Johannes C., additional, Niezen, Sebastian, additional, Delorey, Toni M., additional, Essene, Adam L, additional, Brook, Olga R., additional, Pant, Deepti, additional, Skelton-Badlani, Disha, additional, Naderi, Pourya, additional, Huang, Pinzhu, additional, Pan, Liuliu, additional, Hether, Tyler, additional, Andrews, Tallulah S., additional, Ziegler, Carly G.K., additional, Reeves, Jason, additional, Myloserdnyy, Andriy, additional, Chen, Rachel, additional, Nam, Andy, additional, Phelan, Stefan, additional, Liang, Yan, additional, Amin, Amit Dipak, additional, Biermann, Jana, additional, Hibshoosh, Hanina, additional, Veregge, Molly, additional, Kramer, Zachary, additional, Jacobs, Christopher, additional, Yalcin, Yusuf, additional, Phillips, Devan, additional, Slyper, Michal, additional, Subramanian, Ayshwarya, additional, Ashenberg, Orr, additional, Bloom-Ackermann, Zohar, additional, Tran, Victoria M., additional, Gomez, James, additional, Sturm, Alexander, additional, Zhang, Shuting, additional, Fleming, Stephen J., additional, Warren, Sarah, additional, Beechem, Joseph, additional, Hung, Deborah, additional, Babadi, Mehrtash, additional, Padera, Robert F., additional, MacParland, Sonya A., additional, Bader, Gary D., additional, Imad, Nasser, additional, Solomon, Isaac H., additional, Miller, Eric, additional, Riedel, Stefan, additional, Porter, Caroline B.M., additional, Villani, Alexandra-Chloé, additional, Tsai, Linus T.-Y., additional, Hide, Winston, additional, Szabo, Gyongyi, additional, Hecht, Jonathan, additional, Rozenblatt-Rosen, Orit, additional, Shalek, Alex K., additional, Izar, Benjamin, additional, Regev, Aviv, additional, Popov, Yury, additional, Jiang, Z. Gordon, additional, and Vlachos, Ioannis S., additional

Published
2022
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9. Mouse fetal growth restriction through parental and fetal immune gene variation and intercellular communications cascade

Author

Kaur, Gurman, Porter, Caroline B.M., Ashenberg, Orr, Lee, Jack, Riesenfeld, Samantha J., Hofree, Matan, Aggelakopoulou, Maria, Subramanian, Ayshwarya, Kuttikkatte, Subita Balaram, Attfield, Kathrine E., Desel, Christiane A.E., Davies, Jessica L., Evans, Hayley G., Avraham-Davidi, Inbal, Nguyen, Lan T., Dionne, Danielle A., Neumann, Anna E., Jensen, Lise Torp, Barber, Thomas R., Soilleux, Elizabeth, Carrington, Mary, McVean, Gil, Rozenblatt-Rosen, Orit, Regev, Aviv, Fugger, Lars, Kaur, Gurman, Porter, Caroline B.M., Ashenberg, Orr, Lee, Jack, Riesenfeld, Samantha J., Hofree, Matan, Aggelakopoulou, Maria, Subramanian, Ayshwarya, Kuttikkatte, Subita Balaram, Attfield, Kathrine E., Desel, Christiane A.E., Davies, Jessica L., Evans, Hayley G., Avraham-Davidi, Inbal, Nguyen, Lan T., Dionne, Danielle A., Neumann, Anna E., Jensen, Lise Torp, Barber, Thomas R., Soilleux, Elizabeth, Carrington, Mary, McVean, Gil, Rozenblatt-Rosen, Orit, Regev, Aviv, and Fugger, Lars

Abstract

Fetal growth restriction (FGR) affects 5–10% of pregnancies, and can have serious consequences for both mother and child. Prevention and treatment are limited because FGR pathogenesis is poorly understood. Genetic studies implicate KIR and HLA genes in FGR, however, linkage disequilibrium, genetic influence from both parents, and challenges with investigating human pregnancies make the risk alleles and their functional effects difficult to map. Here, we demonstrate that the interaction between the maternal KIR2DL1, expressed on uterine natural killer (NK) cells, and the paternally inherited HLA-C*0501, expressed on fetal trophoblast cells, leads to FGR in a humanized mouse model. We show that the KIR2DL1 and C*0501 interaction leads to pathogenic uterine arterial remodeling and modulation of uterine NK cell function. This initial effect cascades to altered transcriptional expression and intercellular communication at the maternal-fetal interface. These findings provide mechanistic insight into specific FGR risk alleles, and provide avenues of prevention and treatment.

Published
2022

10. Emergence of a High-Plasticity Cell State during Lung Cancer Evolution

Author

Koch Institute for Integrative Cancer Research at MIT, Massachusetts Institute of Technology. Computational and Systems Biology Program, Massachusetts Institute of Technology. Department of Biology, Howard Hughes Medical Institute, Marjanovic, Nemanja Despot, Hofree, Matan, Chan, Jason E., Canner, David, Wu, Katherine, Trakala, Marianna, Hartmann, Griffin G., Smith, Olivia C., Kim, Jonathan Y., Evans, Kelly Victoria, Hudson, Anna, Ashenberg, Orr, Porter, Caroline B.M., Bejnood, Alborz, Subramanian, Ayshwarya, Pitter, Kenneth, Yan, Yan, Delorey, Toni, Phillips, Devan R., Shah, Nisargbhai, Chaudhary, Ojasvi, Tsankov, Alexander, Hollmann, Travis, Rekhtman, Natasha, Massion, Pierre P., Poirier, John T., Mazutis, Linas, Li, Ruifang, Lee, Joo-Hyeon, Amon, Angelika, Rudin, Charles M., Jacks, Tyler, Regev, Aviv, Tammela, Tuomas, Koch Institute for Integrative Cancer Research at MIT, Massachusetts Institute of Technology. Computational and Systems Biology Program, Massachusetts Institute of Technology. Department of Biology, Howard Hughes Medical Institute, Marjanovic, Nemanja Despot, Hofree, Matan, Chan, Jason E., Canner, David, Wu, Katherine, Trakala, Marianna, Hartmann, Griffin G., Smith, Olivia C., Kim, Jonathan Y., Evans, Kelly Victoria, Hudson, Anna, Ashenberg, Orr, Porter, Caroline B.M., Bejnood, Alborz, Subramanian, Ayshwarya, Pitter, Kenneth, Yan, Yan, Delorey, Toni, Phillips, Devan R., Shah, Nisargbhai, Chaudhary, Ojasvi, Tsankov, Alexander, Hollmann, Travis, Rekhtman, Natasha, Massion, Pierre P., Poirier, John T., Mazutis, Linas, Li, Ruifang, Lee, Joo-Hyeon, Amon, Angelika, Rudin, Charles M., Jacks, Tyler, Regev, Aviv, and Tammela, Tuomas

Abstract

Tumor evolution from a single cell into a malignant, heterogeneous tissue remains poorly understood. Here, we profile single-cell transcriptomes of genetically engineered mouse lung tumors at seven stages, from pre-neoplastic hyperplasia to adenocarcinoma. The diversity of transcriptional states increases over time and is reproducible across tumors and mice. Cancer cells progressively adopt alternate lineage identities, computationally predicted to be mediated through a common transitional, high-plasticity cell state (HPCS). Accordingly, HPCS cells prospectively isolated from mouse tumors and human patient-derived xenografts display high capacity for differentiation and proliferation. The HPCS program is associated with poor survival across human cancers and demonstrates chemoresistance in mice. Our study reveals a central principle underpinning intra-tumoral heterogeneity and motivates therapeutic targeting of the HPCS. Cellular states capable of promoting tumor progression and resisting therapies exist in heterogeneous tumors. Marjanovic et al. discover that a high-plasticity cell state common to mouse and human lung tumors drives cellular heterogeneity, is highly tumorigenic and drug resistant, and associates with poor patient prognosis.

Published
2022

11. A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2

Author

Delorey, Toni M., primary, Ziegler, Carly G. K., additional, Heimberg, Graham, additional, Normand, Rachelly, additional, Yang, Yiming, additional, Segerstolpe, Asa, additional, Abbondanza, Domenic, additional, Fleming, Stephen J., additional, Subramanian, Ayshwarya, additional, Montoro, Daniel T., additional, Jagadeesh, Karthik A., additional, Dey, Kushal K., additional, Sen, Pritha, additional, Slyper, Michal, additional, Pita-Juárez, Yered H., additional, Phillips, Devan, additional, Bloom-Ackerman, Zohar, additional, Barkas, Nick, additional, Ganna, Andrea, additional, Gomez, James, additional, Normandin, Erica, additional, Naderi, Pourya, additional, Popov, Yury V., additional, Raju, Siddharth S., additional, Niezen, Sebastian, additional, Tsai, Linus T.-Y., additional, Siddle, Katherine J., additional, Sud, Malika, additional, Tran, Victoria M., additional, Vellarikkal, Shamsudheen K., additional, Amir-Zilberstein, Liat, additional, Atri, Deepak S., additional, Beechem, Joseph, additional, Brook, Olga R., additional, Chen, Jonathan, additional, Divakar, Prajan, additional, Dorceus, Phylicia, additional, Engreitz, Jesse M., additional, Essene, Adam, additional, Fitzgerald, Donna M., additional, Fropf, Robin, additional, Gazal, Steven, additional, Gould, Joshua, additional, Grzyb, John, additional, Harvey, Tyler, additional, Hecht, Jonathan, additional, Hether, Tyler, additional, Jane-Valbuena, Judit, additional, Leney-Greene, Michael, additional, Ma, Hui, additional, McCabe, Cristin, additional, McLoughlin, Daniel E., additional, Miller, Eric M., additional, Muus, Christoph, additional, Niemi, Mari, additional, Padera, Robert, additional, Pan, Liuliu, additional, Pant, Deepti, additional, Pe’er, Carmel, additional, Pfiffner-Borges, Jenna, additional, Pinto, Christopher J., additional, Plaisted, Jacob, additional, Reeves, Jason, additional, Ross, Marty, additional, Rudy, Melissa, additional, Rueckert, Erroll H., additional, Siciliano, Michelle, additional, Sturm, Alexander, additional, Todres, Ellen, additional, Waghray, Avinash, additional, Warren, Sarah, additional, Zhang, Shuting, additional, Zollinger, Daniel R., additional, Cosimi, Lisa, additional, Gupta, Rajat M., additional, Hacohen, Nir, additional, Hide, Winston, additional, Price, Alkes L., additional, Rajagopal, Jayaraj, additional, Tata, Purushothama Rao, additional, Riedel, Stefan, additional, Szabo, Gyongyi, additional, Tickle, Timothy L., additional, Hung, Deborah, additional, Sabeti, Pardis C., additional, Novak, Richard, additional, Rogers, Robert, additional, Ingber, Donald E., additional, Gordon Jiang, Z., additional, Juric, Dejan, additional, Babadi, Mehrtash, additional, Farhi, Samouil L., additional, Stone, James R., additional, Vlachos, Ioannis S., additional, Solomon, Isaac H., additional, Ashenberg, Orr, additional, Porter, Caroline B.M., additional, Li, Bo, additional, Shalek, Alex K., additional, Villani, Alexandra-Chloé, additional, Rozenblatt-Rosen, Orit, additional, and Regev, Aviv, additional

Published
2021
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