2,881 results on '"Porter S"'
Search Results
2. Opioid use, prescribing patterns, and disposal after surgical procedures
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Hanson, Lauryn B., Hummel, Porter S., Kokko-Ludemann, Jacob W., Lee, Kristi, and Polgreen, Linnea A.
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- 2024
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3. High Resolution Search for KBO Binaries from New Horizons
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Weaver, H. A., Porter, S. B., Spencer, J. R., and Team, The New Horizons Science
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Astrophysics - Earth and Planetary Astrophysics - Abstract
Using the New Horizons LORRI camera, we searched for satellites near five Kuiper belt objects (KBOs): four cold classicals (CCs: 2011 JY31, 2014 OS393, 2014 PN70, 2011 HZ102) and one scattered disk object (SD: 2011 HK103). These objects were observed at distances of 0.092-0.290 au from the New Horizons spacecraft, achieving spatial resolutions of 136-430 km (resolution is ~2 camera pixels), much higher than possible from any other facilities. Here we report that CC 2011 JY31 is a binary system with roughly equal brightness components, CC 2014 OS393 is likely an equal brightness binary system, while the three other KBOs did not show any evidence of binarity. The 2011 JY31 binary has a semi-major axis of 198.6 +/- 2.9 km, an orbital inclination of 61.34 +/- 1.34 deg, and an orbital period of 1.940 +/- 0.002 d. The 2014 OS393 binary objects have an apparent separation of ~150 km, making 2011 JY31 and 2014 OS393 the tightest KBO binary systems ever resolved. Both 2011 HK103 and 2011 HZ102 were detected with SNR~10, and our observations rule out equal brightness binaries with separations larger than ~430 km and ~260 km, respectively. The spatial resolution for 2014 PN70 was ~200 km, but this object had SNR~2.5-3, which limited our ability to probe its binarity. The binary frequency for the CC binaries probed in our small survey (67%, not including 2014 PN70) is consistent with the high binary frequency suggested by larger surveys of CCs (Fraser et al. 2017, Noll et al. 2020) and recent planetesimal formation models (Nesvorny et al. 2021), but we extend the results to smaller orbit semi-major axes and smaller objects than previously possible., Comment: 30 pages, 15 figures
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- 2022
4. Detection of a Satellite of the Trojan Asteroid (3548) Eurybates -- A Lucy Mission Target
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Noll, K. S., Brown, M. E., Weaver, H. A., Grundy, W. M., Porter, S. B., Buie, M. W., Levison, H. F., Olkin, C., Spencer, J. R., Marchi, S., and Statler, T. S.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
We describe the discovery of a satellite of the Trojan asteroid (3548) Eurybates in images obtained with the Hubble Space Telescope. The satellite was detected on three separate epochs, two in September 2018 and one in January 2020. The satellite has a brightness in all three epochs consistent with an effective diameter of d2 =1.2+/-0.4 km. The projected separation from Eurybates was s~1700-2300 km and varied in position, consistent with a large range of possible orbits. Eurybates is a target of the Lucy Discovery mission and the early detection of a satellite provides an opportunity for a significant expansion of the scientific return from this encounter., Comment: 18 pages, 4 figures
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- 2020
5. Initial results from the New Horizons exploration of 2014 MU69, a small Kuiper Belt Object
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Stern, S. A., Weaver, H. A., Spencer, J. R., Olkin, C. B., Gladstone, G. R., Grundy, W. M., Moore, J. M., Cruikshank, D. P., Elliott, H. A., McKinnon, W. B., Parker, J. Wm., Verbiscer, A. J., Young, L. A., Aguilar, D. A., Albers, J. M., Andert, T., Andrews, J. P., Bagenal, F., Banks, M. E., Bauer, B. A., Bauman, J. A., Bechtold, K. E., Beddingfield, C. B., Behrooz, N., Beisser, K. B., Benecchi, S. D., Bernardoni, E., Beyer, R. A., Bhaskaran, S., Bierson, C. J., Binzel, R. P., Birath, E. M., Bird, M. K., Boone, D. R., Bowman, A. F., Bray, V. J., Britt, D. T., Brown, L. E., Buckley, M. R., Buie, M. W., Buratti, B. J., Burke, L. M., Bushman, S. S., Carcich, B., Chaikin, A. L., Chavez, C. L., Cheng, A. F., Colwell, E. J., Conard, S. J., Conner, M. P., Conrad, C. A., Cook, J. C., Cooper, S. B., Custodio, O. S., Ore, C. M. Dalle, Deboy, C. C., Dharmavaram, P., Dhingra, R. D., Dunn, G. F., Earle, A. M., Egan, A. F., Eisig, J., El-Maarry, M. R., Engelbrecht, C., Enke, B. L., Ercol, C. J., Fattig, E. D., Ferrell, C. L., Finley, T. J., Firer, J., Fischetti, J., Folkner, W. M., Fosbury, M. N., Fountain, G. H., Freeze, J. M., Gabasova, L., Glaze, L. S., Green, J. L., Griffith, G. A., Guo, Y., Hahn, M., Hals, D. W., Hamilton, D. P., Hamilton, S. A., Hanley, J. J., Harch, A., Harmon, K. A., Hart, H. M., Hayes, J., Hersman, C. B., Hill, M. E., Hill, T. A., Hofgartner, J. D., Holdridge, M. E., Horányi, M., Hosadurga, A., Howard, A. D., Howett, C. J. A., Jaskulek, S. E., Jennings, D. E., Jensen, J. R., Jones, M. R., Kang, H. K., Katz, D. J., Kaufmann, D. E., Kavelaars, J. J., Keane, J. T., Keleher, G. P., Kinczyk, M., Kochte, M. C., Kollmann, P., Krimigis, S. M., Kruizinga, G. L., Kusnierkiewicz, D. Y., Lahr, M. S., Lauer, T. R., Lawrence, G. B., Lee, J. E., Lessac-Chenen, E. J., Linscott, I. R., Lisse, C. M., Lunsford, A. W., Mages, D. M., Mallder, V. A., Martin, N. P., May, B. H., McComas, D. J., McNutt, R. L., Mehoke, Jr. D. S., Mehoke, T. S., Nelson, D. S., Nguyen, H. D., Núñez, J. I., Ocampo, A. C., Owen, W. M., Oxton, G. K., Parker, A. H., Pätzold, M., Pelgrift, J. Y., Pelletier, F. J., Pineau, J. P., Piquette, M. R., Porter, S. B., Protopapa, S., Quirico, E., Redfern, J. A., Regiec, A. L., Reitsema, H. J., Reuter, D. C., Richardson, D. C., Riedel, J. E., Ritterbush, M. A., Robbins, S. J., Rodgers, D. J., Rogers, G. D., Rose, D. M., Rosendall, P. E., Runyon, K. D., Ryschkewitsch, M. G., Saina, M. M., Salinas, M. J., Schenk, P. M., Scherrer, J. R., Schlei, W. R., Schmitt, B., Schultz, D. J., Schurr, D. C., Scipioni, F., Sepan, R. L., Shelton, R. G., Showalter, M. R., Simon, M., Singer, K. N., Stahlheber, E. W., Stanbridge, D. R., Stansberry, J. A., Steffl, A. J., Strobel, D. F., Stothoff, M. M., Stryk, T., Stuart, J. R., Summers, M. E., Tapley, M. B., Taylor, A., Taylor, H. W., Tedford, R. M., Throop, H. B., Turner, L. S., Umurhan, O. M., Van Eck, J., Velez, D., Versteeg, M. H., Vincent, M. A., Webbert, R. W., Weidner, S. E., Weigle II, G. E., Wendel, J. R., White, O. L., Whittenburg, K. E., Williams, B. G., Williams, K. E., Williams, S. P., Winters, H. L., Zangari, A. M., and Zurbuchen, T. H.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
The Kuiper Belt is a distant region of the Solar System. On 1 January 2019, the New Horizons spacecraft flew close to (486958) 2014 MU69, a Cold Classical Kuiper Belt Object, a class of objects that have never been heated by the Sun and are therefore well preserved since their formation. Here we describe initial results from these encounter observations. MU69 is a bi-lobed contact binary with a flattened shape, discrete geological units, and noticeable albedo heterogeneity. However, there is little surface color and compositional heterogeneity. No evidence for satellites, ring or dust structures, gas coma, or solar wind interactions was detected. By origin MU69 appears consistent with pebble cloud collapse followed by a low velocity merger of its two lobes., Comment: 43 pages, 8 figure
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- 2020
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6. The Geology and Geophysics of Kuiper Belt Object (486958) Arrokoth
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Spencer, J. R., Stern, S. A., Moore, J. M., Weaver, H. A., Singer, K. N., Olkin, C. B., Verbiscer, A. J., McKinnon, W. B., Parker, J. Wm., Beyer, R. A., Keane, J. T., Lauer, T. R., Porter, S. B., White, O. L., Buratti, B. J., El-Maarry, M. R., Lisse, C. M., Parker, A. H., Throop, H. B., Robbins, S. J., Umurhan, O. M., Binzel, R. P., Britt, D. T., Buie, M. W., Cheng, A. F., Cruikshank, D. P., Elliott, H. A., Gladstone, G. R., Grundy, W. M., Hill, M. E., Horanyi, M., Jennings, D. E., Kavelaars, J. J., Linscott, I. R., McComas, D. J., McNutt, R. L., Protopapa, S., Reuter, D. C., Schenk, P. M., Showalter, M. R., Young, L. A., Zangari, A. M., Abedin, A. Y., Beddingfield, C. B., Benecchi, S. D., Bernardoni, E., Bierson, C. J., Borncamp, D., Bray, V. J., Chaikin, A. L., Dhingra, R. D., Fuentes, C., Fuse, T., Gay, P. L, Gwyn, S. D. J., Hamilton, D. P., Hofgartner, J. D., Holman, M. J., Howard, A. D., Howett, C. J. A., Karoji, H., Kaufmann, D. E., Kinczyk, M., May, B. H., Mountain, M., Pätzold, M., Petit, J. M., Piquette, M. R., Reid, I. N., Reitsema, H. J., Runyon, K. D., Sheppard, S. S., Stansberry, J. A., Stryk, T., Tanga, P., Tholen, D. J., Trilling, D. E., and Wasserman, L. H.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
The Cold Classical Kuiper Belt, a class of small bodies in undisturbed orbits beyond Neptune, are primitive objects preserving information about Solar System formation. The New Horizons spacecraft flew past one of these objects, the 36 km long contact binary (486958) Arrokoth (2014 MU69), in January 2019. Images from the flyby show that Arrokoth has no detectable rings, and no satellites (larger than 180 meters diameter) within a radius of 8000 km, and has a lightly-cratered smooth surface with complex geological features, unlike those on previously visited Solar System bodies. The density of impact craters indicates the surface dates from the formation of the Solar System. The two lobes of the contact binary have closely aligned poles and equators, constraining their accretion mechanism.
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- 2020
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7. The solar nebula origin of (486958) Arrokoth, a primordial contact binary in the Kuiper belt
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McKinnon, W. B., Richardson, D. C., Marohnic, J. C., Keane, J. T., Grundy, W. M., Hamilton, D. P., Nesvorny, D., Umurhan, O. M., Lauer, T. R., Singer, K. N., Stern, S. A., Weaver, H. A., Spencer, J. R., Buie, M. W., Moore, J. M., Kavelaars, J. J., Lisse, C. M., Mao, X., Parker, A. H., Porter, S. B., Showalter, M. R., Olkin, C. B., Cruikshank, D. P., Elliott, H. A., Gladstone, G. R., Parker, J. W., Verbiscer, A. J., Young, L. A., and Team, the New Horizons Science
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Astrophysics - Earth and Planetary Astrophysics - Abstract
The New Horizons spacecraft's encounter with the cold classical Kuiper belt object (486958) Arrokoth (formerly 2014 MU69) revealed a contact-binary planetesimal. We investigate how it formed, finding it is the product of a gentle, low-speed merger in the early Solar System. Its two lenticular lobes suggest low-velocity accumulation of numerous smaller planetesimals within a gravitationally collapsing, solid particle cloud. The geometric alignment of the lobes indicates the lobes were a co-orbiting binary that experienced angular momentum loss and subsequent merger, possibly due to dynamical friction and collisions within the cloud or later gas drag. Arrokoth's contact-binary shape was preserved by the benign dynamical and collisional environment of the cold classical Kuiper belt, and so informs the accretion processes that operated in the early Solar System., Comment: Published in Science 28 Feb 2020 (First release 13 Feb 2020)
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- 2020
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8. Color, Composition, and Thermal Environment of Kuiper Belt Object (486958) Arrokoth
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Grundy, W. M., Bird, M. K., Britt, D. T., Cook, J. C., Cruikshank, D. P., Howett, C. J. A., Krijt, S., Linscott, I. R., Olkin, C. B., Parker, A. H., Protopapa, S., Ruaud, M., Umurhan, O. M., Young, L. A., Ore, C. M. Dalle, Kavelaars, J. J., Keane, J. T., Pendleton, Y. J., Porter, S. B., Scipioni, F., Spencer, J. R., Stern, S. A., Verbiscer, A. J., Weaver, H. A., Binzel, R. P., Buie, M. W., Buratti, B. J., Cheng, A., Earle, A. M., Elliott, H. A., Gabasova, L., Gladstone, G. R., Hill, M. E., Horanyi, M., Jennings, D. E., Lunsford, A. W., McComas, D. J., McKinnon, W. B., McNutt Jr., R. L., Moore, J. M., Parker, J. W., Quirico, E., Reuter, D. C., Schenk, P. M., Schmitt, B., Showalter, M. R., Singer, K. N., Weigle II, G. E., and Zangari, A. M.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
The outer Solar System object (486958) Arrokoth (provisional designation 2014 MU$_{69}$) has been largely undisturbed since its formation. We study its surface composition using data collected by the New Horizons spacecraft. Methanol ice is present along with organic material, which may have formed through radiation of simple molecules. Water ice was not detected. This composition indicates hydrogenation of carbon monoxide-rich ice and/ or energetic processing of methane condensed on water ice grains in the cold, outer edge of the early Solar System. There are only small regional variations in color and spectra across the surface, suggesting Arrokoth formed from a homogeneous or well-mixed reservoir of solids. Microwave thermal emission from the winter night side is consistent with a mean brightness temperature of 29$\pm$5 K., Comment: 31 pages, 8 figures
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- 2020
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9. Erratum
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Slee, A, McKeaveney, C, Adamson, G, Davenport, A, Far-Rington, K, Fouque, D, Kalantar-Zadeh, K, Mallett, J, Maxwell, AP, Mullan, R, Noble, H, O'Donoghue, D, Porter, S, Seres, DS, Shields, J, Witham, M, and Reid, J
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Biomedical and Clinical Sciences ,Clinical Sciences ,Nutrition and Dietetics ,Urology & Nephrology ,Clinical sciences ,Nutrition and dietetics - Published
- 2021
10. Magnetic Dead Layers in La$_{0.7}$Sr$_{0.3}$MnO$_3$ Revisited
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Porter, S. B., Venkatesan, M., Dunne, P., Doudin, B., Rode, K., and Coey, J. M. D.
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Condensed Matter - Materials Science - Abstract
The magnetic dead layers in films a few nanometers thick are investigated for La$_{0.7}$Sr$_{0.3}$MnO$_3$ on (001)-oriented SrTiO$_3$ (STO), LaAlO$_3$ (LAO) and (LaAlO$_3$)$_{0.3}$(Sr$_2$TaAlO$_6$)$_{0.7}$ (LSAT) substrates. An anomalous moment found to persist above the Curie temperature of the La$_{0.7}$Sr$_{0.3}$MnO$_3$ films is not attributed to the films, but to oxygen vacancies at or near the surface of the substrate. The contribution to the moment from the substrate is as high as 20 $\mu$B/nm$^2$ in the case of STO or LSAT. The effect is increased by adding an STO cap layer. Taking this d-zero magnetism into account, extrapolated magnetic dead layer thicknesses of 0.8 nm, 1.5 nm and 3.0 nm are found for the manganite films grown on LSAT, STO and LAO substrates, respectively. An STO cap layer eliminates the LSMO dead layer.
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- 2019
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11. Reorientation of Sputnik Planitia implies a Subsurface Ocean on Pluto
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Nimmo, F., Hamilton, D. P., Schenk, W. B. McKinnon P. M., Binzel, R. P., Bierson, C. J., Beyer, R. A., Moore, J. M., Stern, S. A., Weaver, H. A., Olkin, C., Young, L. A., Smith, K. E., Spencer, J. R., Buie, M., Buratti, B., Cheng, A., Cruikshank, D., Ore, C. Dalle, Earle, A., Gladstone, R., Grundy, W., Howard, A. D., Lauer, T., Linscott, I., Parker, J., Porter, S., Reitsema, H., Reuter, D., Roberts, J. H., Robbins, S., Showalter, M., Singer, K., Strobel, D., Summers, M., Tyler, L., Weaver, H., White, O. L., Umurhan, O. M., Banks, M., Barnouin, O., Bray, V., Carcich, B., Chaikin, A., Chavez, C., Conrad, C., Howett, C., Hofgartner, J., Kammer, J., Lisse, C., Marcotte, A., Parker, A., Retherford, K., Saina, M., Runyon, K., Schindhelm, R., Stansberry, J., Steffl, A., Stryk, T., Throop, . H., Tsang, C., Verbiscer, A., Winters, H., and Zangari, A.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
The deep nitrogen-covered Sputnik Planitia (SP; informal name) basin on Pluto is located very close to the longitude of Pluto's tidal axis[1] and may be an impact feature [2], by analogy with other large basins in the solar system[3,4]. Reorientation[5-7] due to tidal and rotational torques can explain SP's location, but requires it to be a positive gravity anomaly[7], despite its negative topography. Here we argue that if SP formed via impact and if Pluto possesses a subsurface ocean, a positive gravity anomaly would naturally result because of shell thinning and ocean uplift, followed by later modest N2 deposition. Without a subsurface ocean a positive gravity anomaly requires an implausibly thick N2 layer (greater than 40 km). A rigid, conductive ice shell is required to prolong such an ocean's lifetime to the present day[8] and maintain ocean uplift. Because N2 deposition is latitude-dependent[9], nitrogen loading and reorientation may have exhibited complex feedbacks[7].
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- 2019
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12. Convection in a volatile nitrogen-ice-rich layer drives Pluto's geological vigor
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McKinnon, William B., Nimmo, Francis, Wong, Teresa, Schenk, Paul M., White, Oliver L., Roberts, J. H., Moore, J. M., Spencer, J. R., Howard, A. D., Umurhan, O. M., Stern, S. A., Weaver, H. A., Olkin, C. B., Young, L. A., Smith, K. E., Beyer, R., Binzel, R. P., Buie, M., Buratti, B., Cheng, A., Cruikshank, D., Ore, C. Dalle, Earle, A., Gladstone, R., Grundy, W., Lauer, T., Linscott, I., Parker, J., Porter, S., Reitsema, H., Reuter, D., Robbins, S., Showalter, M., Singer, K., Strobel, D., Summers, M., Tyler, L., Weaver, H., Banks, M., Barnouin, O., Bray, V., Carcich, B., Chaikin, A., Chavez, C., Conrad, C., Hamilton, D., Howett, C., Hofgartner, J., Kammer, J., Lisse, C., Marcotte, A., Parker, A., Retherford, K., Saina, M., Runyon, K., Schindhelm, R., Stansberry, J., Steffl, A., Stryk, T., Throop, . H., Tsang, C., Verbiscer, A., Winters, H., and Zangari, A.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
The vast, deep, volatile-ice-filled basin informally named Sputnik Planum is central to Pluto's geological activity[1,2]. Composed of molecular nitrogen, methane, and carbon monoxide ices[3], but dominated by N2-ice, this ice layer is organized into cells or polygons, typically ~10-40 km across, that resemble the surface manifestation of solid state convection[1,2]. Here we report, based on available rheological measurements[4], that solid layers of N2 ice approximately greater than 1 km thick should convect for estimated present-day heat flow conditions on Pluto. More importantly, we show numerically that convective overturn in a several-km-thick layer of solid nitrogen can explain the great lateral width of the cells. The temperature dependence of N2-ice viscosity implies that the SP ice layer convects in the so-called sluggish lid regime[5], a unique convective mode heretofore not definitively observed in the Solar System. Average surface horizontal velocities of a few cm/yr imply surface transport or renewal times of ~500,000 years, well under the 10 Myr upper limit crater retention age for Sputnik Planum[2]. Similar convective surface renewal may also occur on other dwarf planets in the Kuiper belt, which may help explain the high albedos of some of them.
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- 2019
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13. Formation of Charon's Red Poles From Seasonally Cold-Trapped Volatiles
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Grundy, W. M., Cruikshank, D. P., Gladstone, G. R., Howett, C. J. A., Lauer, T. R., Spencer, J. R., Summers, M. E., Buie, M. W., Earle, A. M., Ennico, K., Parker, J. Wm., Porter, S. B., Singer, K. N., Stern, S. A., Verbiscer, A. J., Beyer, R. A., Binzel, R. P., Buratti, B. J., Cook, J. C., Ore, C. M. Dalle, Olkin, C. B., Parker, A. H., Protopapa, S., Quirico, E., Retherford, K. D., Robbins, S. J., Schmitt, B., Stansberry, J. A., Umurhan, O. M., Weaver, H. A., Young, L. A., Zangari, A. M., Bray, V. J., Cheng, A. F., McKinnon, W. B., McNutt Jr., R. L., Moore, J. M., Nimmo, F., Reuter, D. C., Schenk, P. M., and Team, the New Horizons Science
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Astrophysics - Earth and Planetary Astrophysics - Abstract
A unique feature of Pluto's large satellite Charon is its dark red northern polar cap. Similar colours on Pluto's surface have been attributed to organic macromolecules produced by energetic radiation processing of hydrocarbons. The polar location of this material on Charon implicates the temperature extremes that result from Charon's high obliquity and long seasons. The escape of Pluto's atmosphere provides a potential feed stock for production of complex chemistry. Gas from Pluto that is transiently cold-trapped and processed at Charon's winter pole was proposed as an explanation on the basis of an image of Charon's northern hemisphere, but not modelled quantitatively. Here we report images of the southern hemisphere illuminated by Pluto-shine and also images taken during the approach phase showing the northern polar cap over a range of longitudes. We model the surface thermal environment on Charon, the supply and temporary cold-trapping of material escaping from Pluto, and, while cold-trapped, its photolytic processing into more complex and less volatile molecules. The model results are consistent with the proposed mechanism producing the observed colour pattern on Charon.
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- 2019
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14. The HST Lightcurve of (486958) 2014 MU69
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Benecchi, S. D., Porter, S., Buie, M. W., Zangari, A. M., Verbiscer, A. J., Noll, K. S., Stern, S. A., Spencer, J. R., and Parker, A.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
We report HST lightcurve observations of the New Horizons (NH) spacecraft encounter KBO (486958) 2014 MU69 acquired near opposition in July 2017. In order to plan the optimum flyby sequence the NH mission planners needed to learn as much as possible about the target in advance of the encounter. Specifically, from lightcurve data, encounter timing could be adjusted to accommodate a highly elongated, binary, or rapidly rotating target. HST astrometric (Porter et al. 2018) and stellar occultation (Buie et al. 2018) observations constrained MU69's orbit and diameter (21-41 km for an albedo of 0.15-0.04), respectively. Photometry from the astrometric dataset suggested a variability of $\ge$0.3 mags, but they did not determine the period or provide shape information. We strategically spaced 24 HST orbits over 9 days to investigate rotation periods from approximately 2-100 hours and to better constrain the lightcurve amplitude. Until NH detected MU69 in its optical navigation images beginning in August 2018, this HST campaign provided the most accurate photometry to date. The mean variation in our data is 0.15 mags which suggests that MU69 is either nearly spherical (a:b axis ratio of 1:1.15), or its pole vector is pointed near the line of sight to Earth; this interpretation does not preclude a near-contact binary or bi-lobed object. However, image stacks do conclude that MU69 does not have a binary companion $\ge$2000 km with a sensitivity to 29th magnitude. We report with confidence that MU69 is not both rapidly rotating and highly elongated. We note that our results are consistent with the fly-by imagery and orientation of MU69 (Stern et al. 2019). The combined dataset also suggests that within the KBO lightcurve literature there are likely other objects which share a geometric configuration like MU69 resulting in an underestimate of the contact binary fraction for the CC Kuiper Belt., Comment: Icarus, in Press
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- 2018
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15. Establishing a clinical phenotype for cachexia in end stage kidney disease – study protocol
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Reid, Joanne, Noble, Helen R, Adamson, Gary, Davenport, Andrew, Farrington, Ken, Fouque, Denis, Kalantar-Zadeh, Kamyar, Mallett, John, McKeaveney, C, Porter, S, Seres, David S, Shields, Joanne, Slee, Adrian, Witham, Miles D, and Maxwell, Alexander P
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Biomedical and Clinical Sciences ,Clinical Sciences ,Health Sciences ,Nutrition ,Clinical Research ,Kidney Disease ,Aetiology ,2.1 Biological and endogenous factors ,Renal and urogenital ,Good Health and Well Being ,Cachexia ,Humans ,Kidney Failure ,Chronic ,Longitudinal Studies ,Patient Selection ,Phenotype ,Renal Dialysis ,United Kingdom ,End-stage kidney disease ,Definition ,Longitudinal ,Urology & Nephrology ,Clinical sciences ,Health services and systems ,Nursing - Abstract
BackgroundSurveys using traditional measures of nutritional status indicate that muscle wasting is common among persons with end-stage kidney disease (ESKD). Up to 75% of adults undergoing maintenance dialysis show some evidence of muscle wasting. ESKD is associated with an increase in inflammatory cytokines and can result in cachexia, with the loss of muscle and fat stores. At present, only limited data are available on the classification of wasting experienced by persons with ESKD. Individuals with ESKD often exhibit symptoms of anorexia, loss of lean muscle mass and altered energy expenditure. These symptoms are consistent with the syndrome of cachexia observed in other chronic diseases, such as cancer, heart failure, and acquired immune deficiency syndrome. While definitions of cachexia have been developed for some diseases, such as cardiac failure and cancer, no specific cachexia definition has been established for chronic kidney disease. The importance of developing a definition of cachexia in a population with ESKD is underscored by the negative impact that symptoms of cachexia have on quality of life and the association of cachexia with a substantially increased risk of premature mortality. The aim of this study is to determine the clinical phenotype of cachexia specific to individuals with ESKD.MethodsA longitudinal study which will recruit adult patients with ESKD receiving haemodialysis attending a Regional Nephrology Unit within the United Kingdom. Patients will be followed 2 monthly over 12 months and measurements of weight; lean muscle mass (bioelectrical impedance, mid upper arm muscle circumference and tricep skin fold thickness); muscle strength (hand held dynamometer), fatigue, anorexia and quality of life collected. We will determine if they experience (and to what degree) the known characteristics associated with cachexia.DiscussionCachexia is a debilitating condition associated with an extremely poor outcome. Definitions of cachexia in chronic illnesses are required to reflect specific nuances associated with each disease. These discrete cachexia definitions help with the precision of research and the subsequent clinical interventions to improve outcomes for patients suffering from cachexia. The absence of a definition for cachexia in an ESKD population makes it particularly difficult to study the incidence of cachexia or potential treatments, as there are no standardised inclusion criteria for patients with ESKD who have cachexia. Outcomes from this study will provide much needed data to inform development and testing of potential treatment modalities, aimed at enhancing current clinical practice, policy and education.
- Published
- 2018
16. Magnetization and Anisotropy of Cobalt Ferrite Thin Films
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Eskandari, F., Porter, S. B., Venkatesan, M., Kameli, P., Rode, K., and Coey, J. M. D.
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Condensed Matter - Materials Science - Abstract
The magnetization of thin films of cobalt ferrite frequently falls far below the bulk value of 455 kAm-1, which corresponds to an inverse cation distribution in the spinel structure with a significant orbital moment of about 0.6 muB that is associated with the octahedrally-coordinated Co2+ ions. The orbital moment is responsible for the magnetostriction and magnetocrystalline anisotropy, and its sensitivity to imposed strain. We have systematically investigated the structure and magnetism of films produced by pulsed-laser deposition on different substrates (TiO2, MgO, MgAl2O4, SrTiO3, LSAT, LaAlO3) and as a function of temperature (500-700 C) and oxygen pressure (10-4 - 10 Pa). Magnetization at room-temperature ranges from 60 to 440 kAm-1, and uniaxial substrate-induced anisotropy ranges from +220 kJm-3 for films on deposited on MgO (100) to -2100 kJm-3 for films deposited on MgAl2O4 (100), where the room-temperature anisotropy field reaches 14 T. No rearrangement of high-spin Fe3+ and Co2+ cations on tetrahedral and octahedral sites can reduce the magnetization below the bulk value, but a switch from Fe3+ and Co2+ to Fe2+ and low-spin Co3+ on octahedral sites will reduce the low-temperature magnetization to 120 kAm-1, and a consequent reduction of Curie temperature can bring the room-temperature value to near zero. Possible reasons for the appearance of low-spin cobalt in the thin films are discussed. Keywords; Cobalt ferrite, thin films, pulsed-laser deposition, low-spin Co3+, strain engineering of magnetization.
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- 2017
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17. Tailoring equiaxed β-grain structures in Ti-6Al-4V coaxial electron beam wire additive manufacturing
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Davis, A.E., Kennedy, J.R., Strong, D., Kovalchuk, D., Porter, S., and Prangnell, P.B.
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- 2021
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18. Embedding patient and public involvement into a doctoral study: developing a point-of-care HIV testing intervention for dental settings
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Doughty, J., primary, Preston, J., additional, Paisi, M., additional, Hudson, A., additional, Burns, F., additional, Porter, S. R., additional, and Watt, R. G., additional
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- 2024
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19. The Geology of Pluto and Charon Through the Eyes of New Horizons
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Moore, Jeffrey M., McKinnon, William B., Spencer, John R., Howard, Alan D., Schenk, Paul M., Beyer, Ross A., Nimmo, Francis, Singer, Kelsi N., Umurhan, Orkan M., White, Oliver L., Stern, S. Alan, Ennico, Kimberly, Olkin, Cathy B., Weaver, Harold A., Young, Leslie A., Binzel, Richard P., Buie, Marc W., Buratti, Bonnie J., Cheng, Andrew F., Cruikshank, Dale P., Grundy, Will M., Linscott, Ivan R., Reitsema, Harold J., Reuter, Dennis C., Showalter, Mark R., Bray, Veronica J., Chavez, Carrie L., Howett, Carly J. A., Lauer, Tod R., Lisse, Carey M., Parker, Alex Harrison, Porter, S. B., Robbins, Simon J., Runyon, Kirby, Stryk, Ted, Throop, Henry B., Tsang, Constantine C. C., Verbiscer, Anne J., Zangari, Amanda M., Chaikin, Andrew L., and Wilhelms, Don E.
- Subjects
Astrophysics - Earth and Planetary Astrophysics - Abstract
NASA's New Horizons spacecraft has revealed the complex geology of Pluto and Charon. Pluto's encounter hemisphere shows ongoing surface geological activity centered on a vast basin containing a thick layer of volatile ices that appears to be involved in convection and advection, with a crater retention age no greater than $\approx$10 Ma. Surrounding terrains show active glacial flow, apparent transport and rotation of large buoyant water-ice crustal blocks, and pitting, likely by sublimation erosion and/or collapse. More enigmatic features include tall mounds with central depressions that are conceivably cryovolcanic, and ridges with complex bladed textures. Pluto also has ancient cratered terrains up to ~4 Ga old that are extensionally fractured and extensively mantled and perhaps eroded by glacial or other processes. Charon does not appear to be currently active, but experienced major extensional tectonism and resurfacing (probably cryovolcanic) nearly 4 billion years ago. Impact crater populations on Pluto and Charon are not consistent with the steepest proposed impactor size-frequency distributions proposed for the Kuiper belt.
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- 2016
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20. The Small Satellites of Pluto as Observed by New Horizons
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Weaver, H. A., Buie, M. W., Buratti, B. J., Grundy, W. M., Lauer, T. R., Olkin, C. B., Parker, A. H., Porter, S. B., Showalter, M. R., Spencer, J. R., Stern, S. A., Verbiscer, A. J., McKinnon, W. B., Moore, J. M., Robbins, S. J., Schenk, P., Singer, K. N., Barnouin, O. S., Cheng, A. F., Ernst, C. M., Lisse, C. M., Jennings, D. E., Lunsford, A. W., Reuter, D. C., Hamilton, D. P., Kaufmann, D. E., Ennico, K., Young, L. A., Beyer, R. A., Binzel, R. P., Bray, V. J., Chaikin, A. L., Cook, J. C., Cruikshank, D. P., Ore, C. M. Dalle, Earle, A. M., Gladstone, G. R., Howett, C. J. A., Linscott, I. R., Nimmo, F., Parker, J. Wm., Philippe, S., Protopapa, S., Reitsema, H. J., Schmitt, B., Stryk, T., Summers, M. E., Tsang, C. C. C., Throop, H. H. B., White, O. L., and Zangari, A. M.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
The New Horizons mission has provided resolved measurements of Pluto's moons Styx, Nix, Kerberos, and Hydra. All four are small, with equivalent spherical diameters of $\approx$40 km for Nix and Hydra and ~10 km for Styx and Kerberos. They are also highly elongated, with maximum to minimum axis ratios of $\approx$2. All four moons have high albedos ( $\approx$50-90 %) suggestive of a water-ice surface composition. Crater densities on Nix and Hydra imply surface ages $\gtrsim$ 4 Ga. The small moons rotate much faster than synchronous, with rotational poles clustered nearly orthogonal to the common pole directions of Pluto and Charon. These results reinforce the hypothesis that the small moons formed in the aftermath of a collision that produced the Pluto-Charon binary., Comment: in Science 351, aae0030 (2016)
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- 2016
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21. Inflight Radiometric Calibration of New Horizons' Multispectral Visible Imaging Camera (MVIC)
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Howett, C. J. A., Parker, A. H., Olkin, C. B., Reuter, D. C., Ennico, K., Grundy, W. M, Graps, A. L., Harrison, K. P., Throop, H. B., Buie, M. W., Lovering, J. R., Porter, S. B., Weaver, H. A., Young, L. A., Stern, S. A., Beyer, R. A., Binzell, R. P., Buratti, B. J., Cheng, A. F., Cook, J. C., Cruikshank, D. P., Ore, C. M. Dalle, Earle, A. M., Jennings, D. E., Linscott, I. R., Lunsford, A. W., Parker, J. Wm., Phillippe, S., Protopapa, S., Quirico, E., Schenk, P. M., Schmitt, B., Singer, K. N., Spencer, J. R., Stansberry, J. A., Tsang, C. C. C., Weigle II, G. E., and Verbiscer, A. J.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Earth and Planetary Astrophysics - Abstract
We discuss two semi-independent calibration techniques used to determine the in-flight radiometric calibration for the New Horizons' Multi-spectral Visible Imaging Camera (MVIC). The first calibration technique compares the observed stellar flux to modeled values. The difference between the two provides a calibration factor that allows the observed flux to be adjusted to the expected levels for all observations, for each detector. The second calibration technique is a channel-wise relative radiometric calibration for MVIC's blue, near-infrared and methane color channels using observations of Charon and scaling from the red channel stellar calibration. Both calibration techniques produce very similar results (better than 7% agreement), providing strong validation for the techniques used. Since the stellar calibration can be performed without a color target in the field of view and covers all of MVIC's detectors, this calibration was used to provide the radiometric keywords delivered by the New Horizons project to the Planetary Data System (PDS). These keywords allow each observation to be converted from counts to physical units; a description of how these keywords were generated is included. Finally, mitigation techniques adopted for the gain drift observed in the near-infrared detector and one of the panchromatic framing cameras is also discussed.
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- 2016
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22. The Alpha Magnetic Spectrometer (AMS) on the international space station: Part II — Results from the first seven years
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Aguilar, M., Ali Cavasonza, L., Ambrosi, G., Arruda, L., Attig, N., Barao, F., Barrin, L., Bartoloni, A., Başeğmez-du Pree, S., Bates, J., Battiston, R., Behlmann, M., Beischer, B., Berdugo, J., Bertucci, B., Bindi, V., de Boer, W., Bollweg, K., Borgia, B., Boschini, M.J., Bourquin, M., Bueno, E.F., Burger, J., Burger, W.J., Burmeister, S., Cai, X.D., Capell, M., Casaus, J., Castellini, G., Cervelli, F., Chang, Y.H., Chen, G.M., Chen, H.S., Chen, Y., Cheng, L., Chou, H.Y., Chouridou, S., Choutko, V., Chung, C.H., Clark, C., Coignet, G., Consolandi, C., Contin, A., Corti, C., Cui, Z., Dadzie, K., Dai, Y.M., Delgado, C., Della Torre, S., Demirköz, M.B., Derome, L., Di Falco, S., Di Felice, V., Díaz, C., Dimiccoli, F., von Doetinchem, P., Dong, F., Donnini, F., Duranti, M., Egorov, A., Eline, A., Feng, J., Fiandrini, E., Fisher, P., Formato, V., Freeman, C., Galaktionov, Y., Gámez, C., García-López, R.J., Gargiulo, C., Gast, H., Gebauer, I., Gervasi, M., Giovacchini, F., Gómez-Coral, D.M., Gong, J., Goy, C., Grabski, V., Grandi, D., Graziani, M., Guo, K.H., Haino, S., Han, K.C., Hashmani, R.K., He, Z.H., Heber, B., Hsieh, T.H., Hu, J.Y., Huang, Z.C., Hungerford, W., Incagli, M., Jang, W.Y., Jia, Yi, Jinchi, H., Kanishev, K., Khiali, B., Kim, G.N., Kirn, Th., Konyushikhin, M., Kounina, O., Kounine, A., Koutsenko, V., Kuhlman, A., Kulemzin, A., La Vacca, G., Laudi, E., Laurenti, G., Lazzizzera, I., Lebedev, A., Lee, H.T., Lee, S.C., Leluc, C., Li, J.Q., Li, M., Li, Q., Li, S., Li, T.X., Li, Z.H., Light, C., Lin, C.H., Lippert, T., Liu, Z., Lu, S.Q., Lu, Y.S., Luebelsmeyer, K., Luo, J.Z., Lyu, S.S., Machate, F., Mañá, C., Marín, J., Marquardt, J., Martin, T., Martínez, G., Masi, N., Maurin, D., Menchaca-Rocha, A., Meng, Q., Mo, D.C., Molero, M., Mott, P., Mussolin, L., Ni, J.Q., Nikonov, N., Nozzoli, F., Oliva, A., Orcinha, M., Palermo, M., Palmonari, F., Paniccia, M., Pashnin, A., Pauluzzi, M., Pensotti, S., Phan, H.D., Plyaskin, V., Pohl, M., Porter, S., Qi, X.M., Qin, X., Qu, Z.Y., Quadrani, L., Rancoita, P.G., Rapin, D., Reina Conde, A., Rosier-Lees, S., Rozhkov, A., Rozza, D., Sagdeev, R., Schael, S., Schmidt, S.M., Schulz von Dratzig, A., Schwering, G., Seo, E.S., Shan, B.S., Shi, J.Y., Siedenburg, T., Solano, C., Song, J.W., Sonnabend, R., Sun, Q., Sun, Z.T., Tacconi, M., Tang, X.W., Tang, Z.C., Tian, J., Ting, Samuel C.C., Ting, S.M., Tomassetti, N., Torsti, J., Tüysüz, C., Urban, T., Usoskin, I., Vagelli, V., Vainio, R., Valente, E., Valtonen, E., Vázquez Acosta, M., Vecchi, M., Velasco, M., Vialle, J.P., Wang, L.Q., Wang, N.H., Wang, Q.L., Wang, S., Wang, X., Wang, Z.X., Wei, J., Weng, Z.L., Wu, H., Xiong, R.Q., Xu, W., Yan, Q., Yang, Y., Yi, H., Yu, Y.J., Yu, Z.Q., Zannoni, M., Zhang, C., Zhang, F., Zhang, F.Z., Zhang, J.H., Zhang, Z., Zhao, F., Zheng, Z.M., Zhuang, H.L., Zhukov, V., Zichichi, A., Zimmermann, N., and Zuccon, P.
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- 2021
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23. Triiodothyronine supplementation in a sheep model of intensive care.
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Maiden, MJ, Torpy, DJ, Ludbrook, GL, Clarke, IJ, Chacko, B, Nash, CH, Matthews, L, Porter, S, Kuchel, TR, Maiden, MJ, Torpy, DJ, Ludbrook, GL, Clarke, IJ, Chacko, B, Nash, CH, Matthews, L, Porter, S, and Kuchel, TR
- Abstract
Triiodothyronine (T3) concentrations in plasma decrease during acute illness and it is unclear if this contributes to disease. Clinical and laboratory studies of T3 supplementation in disease have revealed little or no effect. It is uncertain if short term supplementation of T3 has any discernible effect in a healthy animals. Observational study of intravenous T3 (1 µg/kg/h) for 24 h in a healthy sheep model receiving protocol-guided intensive care supports (T3 group, n=5). A total of 45 endpoints were measured including hemodynamic, respiratory, renal, hematological, metabolic and endocrine parameters. Data were compared with previously published studies of sheep subject to the same support protocol without administered T3 (No T3 group, n=5). Plasma free T3 concentrations were elevated 8-fold by the infusion (pmol/l at 24 h; T3 group 34.9±9.9 vs. No T3 group 4.4±0.3, P<0.01, reference range 1.6 to 6.8). There was no significant physiological response to administration of T3 over the study duration. Supplementation of intravenous T3 for 24 h has no physiological effect on relevant physiological endpoints in healthy sheep. Further research is required to understand if the lack of effect of short-term T3 may be related to kinetics of T3 cellular uptake, metabolism and action, or acute counterbalancing hormone resistance. This information may be helpful in design of clinical T3 supplementation trials.
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- 2024
24. The Pluto system: Initial results from its exploration by New Horizons
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Stern, S. A., Bagenal, F., Ennico, K., Gladstone, G. R., Grundy, W. M., McKinnon, W. B., Moore, J. M., Olkin, C. B., Spencer, J. R., Weaver, H. A., Young, L. A., Andert, T., Andrews, J., Banks, M., Bauer, B., Bauman, J., Barnouin, O. S., Bedini, P., Beisser, K., Beyer, R. A., Bhaskaran, S., Binzel, R. P., Birath, E., Bird, M., Bogan, D. J., Bowman, A., Bray, V. J., Brozovic, M., Bryan, C., Buckley, M. R., Buie, M. W., Buratti, B. J., Bushman, S. S., Calloway, A., Carcich, B., Cheng, A. F., Conard, S., Conrad, C. A., Cook, J. C., Cruikshank, D. P., Custodio, O. S., Ore, C. M. Dalle, Deboy, C., Dischner, Z. J. B., Dumont, P., Earle, A. M., Elliott, H. A., Ercol, J., Ernst, C. M., Finley, T., Flanigan, S. H., Fountain, G., Freeze, M. J., Greathouse, T., Green, J. L., Guo, Y., Hahn, M., Hamilton, D. P., Hamilton, S. A., Hanley, J., Harch, A., Hart, H. M., Hersman, C. B., Hill, A., Hill, M. E., Hinson, D. P., Holdridge, M. E., Horanyi, M., Howard, A. D., Howett, C. J. A., Jackman, C., Jacobson, R. A., Jennings, D. E., Kammer, J. A., Kang, H. K., Kaufmann, D. E., Kollmann, P., Krimigis, S. M., Kusnierkiewicz, D., Lauer, T. R., Lee, J. E., Lindstrom, K. L., Linscott, I. R., Lisse, C. M., Lunsford, A. W., Mallder, V. A., Martin, N., McComas, D. J., McNutt Jr., R. L., Mehoke, D., Mehoke, T., Melin, E. D., Mutchler, M., Nelson, D., Nimmo, F., Nunez, J. I., Ocampo, A., Owen, W. M., Paetzold, M., Page, B., Parker, A. H., Parker, J. W., Pelletier, F., Peterson, J., Pinkine, N., Piquette, M., Porter, S. B., Protopapa, S., Redfern, J., Reitsema, H. J., Reuter, D. C., Roberts, J. H., Robbins, S. J., Rogers, G., Rose, D., Runyon, K., Retherford, K. D., Ryschkewitsch, M. G., Schenk, P., Schindhelm, R., Sepan, B., Showalter, M. R., Singer, K. N., Soluri, M., Stanbridge, D., Steffl, A. J., Strobel, D. F., Stryk, T., Summers, M. E., Szalay, J. R., Tapley, M., Taylor, A., Taylor, H., Throop, H. B., Tsang, C. C. C., Tyler, G. L., Umurhan, O. M., Verbiscer, A. J., Versteeg, M. H., Vincent, M., Webbert, R., Weidner, S., Weigle II, G. E., White, O. L., Whittenburg, K., Williams, B. G., Williams, K., Williams, S., Woods, W. W., Zangari, A. M., and Zirnstein, E.
- Subjects
Astrophysics - Earth and Planetary Astrophysics - Abstract
The Pluto system was recently explored by NASA's New Horizons spacecraft, making closest approach on 14 July 2015. Pluto's surface displays diverse landforms, terrain ages, albedos, colors, and composition gradients. Evidence is found for a water-ice crust, geologically young surface units, surface ice convection, wind streaks, volatile transport, and glacial flow. Pluto's atmosphere is highly extended, with trace hydrocarbons, a global haze layer, and a surface pressure near 10 microbars. Pluto's diverse surface geology and long-term activity raise fundamental questions about how small planets remain active many billions of years after formation. Pluto's large moon Charon displays tectonics and evidence for a heterogeneous crustal composition, its north pole displays puzzling dark terrain. Small satellites Hydra and Nix have higher albedos than expected., Comment: 8 pages - Initial Science paper from NASA's New Horizons Pluto Encounter
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- 2015
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25. The Mutual Orbit, Mass, and Density of the Large Transneptunian Binary System Varda and Ilmar\'e
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Grundy, W. M., Porter, S. B., Benecchi, S. D., Roe, H. G., Noll, K. S., Trujillo, C. A., Thirouin, A., Stansberry, J. A., Barker, E., and Levison, H. F.
- Subjects
Astrophysics - Earth and Planetary Astrophysics - Abstract
From observations by the Hubble Space Telescope, Keck II Telescope, and Gemini North Telescope, we have determined the mutual orbit of the large transneptunian object (174567) Varda and its satellite Ilmar\"e. These two objects orbit one another in a highly inclined, circular or near-circular orbit with a period of 5.75 days and a semimajor axis of 4810 km. This orbit reveals the system mass to be (2.664 +/- 0.064) x 10^20 kg, slightly greater than the mass of the second most massive main-belt asteroid (4) Vesta. The dynamical mass can in turn be combined with estimates of the surface area of the system from Herschel Space Telescope thermal observations to estimate a bulk density of 1.24 +0.50 -0.35 g cm^-3. Varda and Ilmar\"e both have colors similar to the combined colors of the system, B-V = 0.886 +/- 0.025 and V-I = 1.156 +/- 0.029., Comment: 16 pages, 4 tables, 6 figures, in press in Icarus
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- 2015
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26. Plethora of drugs
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Porter, S. and Fedele, S.
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- 2022
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27. ASTRO-H White Paper - High Resolution Spectroscopy of Interstellar and Circumgalactic Gas in the Milky Way and Other Galaxies
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Paerels, F., Yamasaki, N., Anabuki, N., Costantini, E., de Vries, C., Fujimoto, R., Hornschemeier, A., Iizuka, R., Kilbourne, C., Konami, S., LaMassa, S., Loewenstein, M., McCammon, D., Matsushita, K., McNamara, B., Mitsuishi, I., Nagino, R., Nakagawa, T., Porter, S., Sakai, K., Smith, R. K., Takei, Y., Tsuru, T., Uchiyama, H., Yamaguchi, H., and Yamauchi, S.
- Subjects
Astrophysics - High Energy Astrophysical Phenomena - Abstract
We describe the potential of high resolution imaging spectroscopy with the SXS on ASTRO-H to advance our understanding of the interstellar- and circumgalactic media of our own Galaxy, and other galaxies. Topics to be addressed range from absorption spectroscopy of dust in the Galactic interstellar medium, to observations to constrain the total mass-, metal-, and energy flow out of starburst galaxies., Comment: 21 pages, 13 figures, ASTRO-H White Paper
- Published
- 2014
28. An assessment of CFD applied to a catalytic converter system with planar diffuser
- Author
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Porter, S. J.
- Subjects
629.25 ,Computational fluid dynamics ,Turbulence modelling - Abstract
Catalytic converters are widely used in the automotive industry to comply with increasingly stringent emissions regulations. The flow distribution across the catalyst substrate significantly aects its conversion eciency. Measuring the flow in a catalyst system is challenging; computational fluid dynamics (CFD) provides an alternative approach for the assessment of different design concepts and is therefore commonly employed to model flow behaviour. This thesis studies the application of CFD to modelling ow in a two-dimensional system consisting of a catalyst monolith downstream of a wide-angled planar diuser, with total included angle 60°. Computational models are developed using the commercial CFD software STAR-CCM+. Flow predictions are compared to experimental data collected by Mat Yamin, (2012) and also as part of this study. Measurements were obtained on a two-dimensional isothermal flow rig using particle image velocimetry (PIV) and hot-wire anemometry (HWA). Steady flow studies compare different methods of modelling the monolith. Models include the common approach of modelling the monolith as a porous medium and the computationally expensive individual channels model. A hybrid model is developed that combines the two approaches, benefiting from the respective merits of each method. Two monolith lengths are considered, with flow at varying Reynolds numbers. The porous model predicts the downstream velocity prole well for the shorter monolith but overpredicts flow maldistribution for the longer monolith. The inclusion of an entrance effect to account for the pressure losses associated with oblique entry into the monolith channels is studied. Best agreement in downstream velocity is observed when the pressure losses are limited using a critical angle approach. The individual channels model is found to be the most consistently accurate across monolith lengths, attributable to the accurate capture of flow behaviour upon entry into the monolith channels. A novel hybrid model is proposed, which combines the computational efficiency of the porous model with the geometrical accuracy of individual channels. The model is evaluated and is found to provide results similar to the individual channels model, with improved predictions of velocity maxima and minima. Pulsating flow studies present three transient flow regimes with similar inlet pulse shapes and varying Reynolds number and frequency. Predicted velocities in the diuser are in good agreement with PIV flow fields, however CFD predicts higher magnitudes at the shear layer. The model predicts large residual vortices present at the end of the cycle where experimental data shows none; it is concluded that CFD underpredicts turbulence diffusion. Evidence of cyclic variation in experimental data highlights the limitation of URANS turbulence models.
- Published
- 2016
29. The Orbit of Transneptunian Binary Manw\'e and Thorondor and their Upcoming Mutual Events
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Grundy, W. M., Benecchi, S. D., Porter, S. B., and Noll, K. S.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
A new Hubble Space Telescope observation of the 7:4 resonant transneptunian binary system (385446) Manw\"e has shown that, of two previously reported solutions for the orbit of its satellite Thorondor, the prograde one is correct. The orbit has a period of 110.18 $\pm$ 0.02 days, semimajor axis of 6670 $\pm$ 40 km, and an eccentricity of 0.563 $\pm$ 0.007. It will be viewable edge-on from the inner solar system during 2015-2017, presenting opportunities to observe mutual occultation and eclipse events. However, the number of observable events will be small, owing to the long orbital period and expected small sizes of the bodies relative to their separation. This paper presents predictions for events observable from Earth-based telescopes and discusses the associated uncertainties and challenges., Comment: 15 pages, 3 figures, 5 tables
- Published
- 2014
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30. Should I stay or should I go? Intra-population variability in movement behaviour of wide-ranging and resident coastal fishes
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Maggs, J. Q., Cowley, P. D., Porter, S. N., and Childs, A. R.
- Published
- 2019
31. Lighting as a Circadian Rhythm-Entraining and Alertness-Enhancing Stimulus in the Submarine Environment
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Crepeau, L. J., Bullough, J. D., Figueiro, M. G., Porter, S., and Rea, M. S.
- Subjects
Neuroscience: Neuroendocrinology ,Psychology: Physiological Psychology ,Neuroscience: Behavioral Neuroscience ,Neuroendocrinology ,Physiological Psychology ,Behavioral Neuroscience - Abstract
The human brain can only accommodate a circadian rhythm that closely follows 24 hours. Thus, for a work schedule to meet the brain’s hard-wired requirement, it must employ a 24 hour-based program. However, the 6 hours on, 12 hours off (6/12) submarine watchstanding schedule creates an 18-hour “day” that Submariners must follow. Clearly, the 6/12 schedule categorically fails to meet the brain’s operational design, and no schedule other than one tuned to the brain’s 24 hour rhythm can optimize performance. Providing Submariners with a 24 hour-based watchstanding schedule—combined with effective circadian entrainment techniques using carefully-timed exposure to light—would allow crewmembers to work at the peak of their daily performance cycle and acquire more restorative sleep. In the submarine environment, where access to natural light is absent, electric lighting can play an important role in actively entraining—and closely maintaining—circadian regulation. Another area that is likely to have particular importance in the submarine environment is the potential effect of light to help restore or maintain alertness.
- Published
- 2006
32. Mutual Events in the Cold Classical Transneptunian Binary System Sila and Nunam
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Grundy, W. M., Benecchi, S. D., Rabinowitz, D. L., Porter, S. B., Wasserman, L. H., Skiff, B. A., Noll, K. S., Verbiscer, A. J., Buie, M. W., Tourtellotte, S. W., Stephens, D. C., and Levison, H. F.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
Hubble Space Telescope observations between 2001 and 2010 resolved the binary components of the Cold Classical transneptunian object (79360) Sila-Nunam (provisionally designated 1997 CS29). From these observations we have determined the circular, retrograde mutual orbit of Nunam relative to Sila with a period of 12.50995 \pm 0.00036 days and a semimajor axis of 2777 \pm 19 km. A multi-year season of mutual events, in which the two near-equal brightness bodies alternate in passing in front of one another as seen from Earth, is in progress right now, and on 2011 Feb. 1 UT, one such event was observed from two different telescopes. The mutual event season offers a rich opportunity to learn much more about this barely-resolvable binary system, potentially including component sizes, colors, shapes, and albedo patterns. The low eccentricity of the orbit and a photometric lightcurve that appears to coincide with the orbital period are consistent with a system that is tidally locked and synchronized, like the Pluto-Charon system. The orbital period and semimajor axis imply a system mass of (10.84 \pm 0.22) \times 10^18 kg, which can be combined with a size estimate based on Spitzer and Herschel thermal infrared observations to infer an average bulk density of 0.72 +0.37 -0.23 g cm^-3, comparable to the very low bulk densities estimated for small transneptunian binaries of other dynamical classes., Comment: In press in Icarus
- Published
- 2012
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33. ORIGIN: Metal Creation and Evolution from the Cosmic Dawn
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Herder, J. W. den, Piro, L., Ohashi, T., Kouveliotou, C., Hartmann, D. H., Kaastra, J. S., Amati, L., Andersen, M. I., Arnaud, M., Attéia, J-L., Bandler, S., Barbera, M., Barcons, X., Barthelmy, S., Basa, S., Basso, S., Boer, M., Branchini, E., Branduardi-Raymont, G., Borgani, S., Boyarsky, A., Brunetti, G., Budtz-Jorgensen, C., Burrows, D., Butler, N., Campana, S., Caroli, E., Ceballos, M., Christensen, F., Churazov, E., Comastri, A., Colasanti, L., Cole, R., Content, R., Corsi, A., Costantini, E., Conconi, P., Cusumano, G., de Plaa, J., De Rosa, A., Del Santo, M., Di Cosimo, S., De Pasquale, M., Doriese, R., Ettori, S., Evans, P., Ezoe, Y., Ferrari, L., Finger, H., Figueroa-Feliciano, T., Friedrich, P., Fujimoto, R., Furuzawa, A., Fynbo, J., Gatti, F., Galeazzi, M., Gehrels, N., Gendre, B., Ghirlanda, G., Ghisellini, G., Gilfanov, M., Giommi, P., Girardi, M., Grindlay, J., Cocchi, M., Godet, O., Guedel, M., Haardt, F., Hartog, R. den, Hepburn, I., Hermsen, W., Hjorth, J., Hoekstra, H., Holland, A., Hornstrup, A., van der Horst, A., Hoshino, A., Zand, J. in 't, Irwin, K., Ishisaki, Y., Jonker, P., Kitayama, T., Kawahara, H., Kawai, N., Kelley, R., Kilbourne, C., de Korte, P., Kusenko, A., Kuvvetli, I., Labanti, M., Macculi, C., Maiolino, R., Hesse, M. Mas, Matsushita, K., Mazzotta, P., McCammon, D., Méndez, M., Mignani, R., Mineo, T., Mitsuda, K., Mushotzky, R., Molendi, S., Moscardini, L., Natalucci, L., Nicastro, F., O'Brien, P., Osborne, J., Paerels, F., Page, M., Paltani, S., Pedersen, K., Perinati, E., Ponman, T., Pointecouteau, E., Predehl, P., Porter, S., Rasmussen, A., Rauw, G., Röttgering, H., Roncarelli, M., Rosati, P., Quadrini, E., Ruchayskiy, O., Salvaterra, R., Sasaki, S., Sato, K., Savaglio, S., Schaye, J., Sciortino, S., Shaposhnikov, M., Sharples, R., Shinozaki, K., Spiga, D., Sunyaev, R., Suto, Y., Takei, Y., Tanvir, N., Tashiro, M., Tamura, T., Tawara, Y., Troja, E., Tsujimoto, M., Tsuru, T., Ubertini, P., Ullom, J., Ursino, E., Verbunt, F., van de Voort, F., Viel, M., Wachter, S., Watson, D., Weisskopf, M., Werner, N., White, N., Willingale, R., Wijers, R., Yamasaki, N., Yoshikawa, K., and Zane, S.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Cosmology and Extragalactic Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
ORIGIN is a proposal for the M3 mission call of ESA aimed at the study of metal creation from the epoch of cosmic dawn. Using high-spectral resolution in the soft X-ray band, ORIGIN will be able to identify the physical conditions of all abundant elements between C and Ni to red-shifts of z=10, and beyond. The mission will answer questions such as: When were the first metals created? How does the cosmic metal content evolve? Where do most of the metals reside in the Universe? What is the role of metals in structure formation and evolution? To reach out to the early Universe ORIGIN will use Gamma-Ray Bursts (GRBs) to study their local environments in their host galaxies. This requires the capability to slew the satellite in less than a minute to the GRB location. By studying the chemical composition and properties of clusters of galaxies we can extend the range of exploration to lower redshifts (z ~ 0.2). For this task we need a high-resolution spectral imaging instrument with a large field of view. Using the same instrument, we can also study the so far only partially detected baryons in the Warm-Hot Intergalactic Medium (WHIM). The less dense part of the WHIM will be studied using absorption lines at low redshift in the spectra for GRBs., Comment: 34 pages, 13 figures. ESA Cosmic Vision medium-class mission (M3) proposal. Accepted for publication in Experimental Astronomy. Including minor corrections in the author list
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- 2011
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34. Five New and Three Improved Mutual Orbits of Transneptunian Binaries
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Grundy, W. M., Noll, K. S., Nimmo, F., Roe, H. G., Buie, M. W., Porter, S. B., Benecchi, S. D., Stephens, D. C., Levison, H. F., and Stansberry, J. A.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
We present three improved and five new mutual orbits of transneptunian binary systems (58534) Logos-Zoe, (66652) Borasisi-Pabu, (88611) Teharonhiawako-Sawiskera, (123509) 2000 WK183, (149780) Altjira, 2001 QY297, 2003 QW111, and 2003 QY90 based on Hubble Space Telescope and Keck 2 laser guide star adaptive optics observations. Combining the five new orbit solutions with 17 previously known orbits yields a sample of 22 mutual orbits for which the period P, semimajor axis a, and eccentricity e have been determined. These orbits have mutual periods ranging from 5 to over 800 days, semimajor axes ranging from 1,600 to 37,000 km, eccentricities ranging from 0 to 0.8, and system masses ranging from 2 x 10^17 to 2 x 10^22 kg. Based on the relative brightnesses of primaries and secondaries, most of these systems consist of near equal-sized pairs, although a few of the most massive systems are more lopsided. The observed distribution of orbital properties suggests that the most loosely-bound transneptunian binary systems are only found on dynamically cold heliocentric orbits. Of the 22 known binary mutual or-bits, orientation ambiguities are now resolved for 9, of which 7 are prograde and 2 are retro-grade, consistent with a random distribution of orbital orientations, but not with models predicting a strong preference for retrograde orbits. To the extent that other perturbations are not dominant, the binary systems undergo Kozai oscillations of their eccentricities and inclinations with periods of the order of tens of thousands to millions of years, some with strikingly high amplitudes., Comment: In press in Icarus, 29 pages, 5 figures, 13 tables
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- 2011
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35. Cachexia and head and neck squamous cell carcinoma: A scoping review.
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Porter, S. R. and Ukwas, A.
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SQUAMOUS cell carcinoma , *MEDICAL information storage & retrieval systems , *HEAD & neck cancer , *PRIMARY health care , *LIFE expectancy , *SYSTEMATIC reviews , *MEDLINE , *LITERATURE reviews , *CACHEXIA , *ORAL health , *NUTRITION - Abstract
Objective: The objective of this paper was to provide an understanding of cachexia in relation to oral squamous cell carcinoma relevant to oral health care. The paper is a scoping review of aspects of the clinical presentation, aetiology and management of cachexia in relation to oral health and oral health care. Methods: A combined search of MEDLINE and EMBASE databases (via OVID) was conducted using the terms ([Head and Neck] OR [Oral Squamous Cell Carcinoma]) AND (Cachexia). Duplicates were removed and results were subsequently limited to studies published between 2000 and 2023, humans and English language. After screening and full‐text assessment a total number of 87 studies were included in the review. Results: It is evident that cachexia is a not uncommon feature of patients with advanced malignancy of the head and neck driven by a multitude of mechanisms, induced by the tumour itself, that lead to reduced nutritional intake, increased metabolism and loss of adipose and skeletal tissue. Conclusion: While a variety of nutritional, physical, psychological and pharmacological interventions may improve quality and duration of life, ultimately the diagnosis of cachexia in relation to head and neck cancer remains an indicator of poor life expectancy. [ABSTRACT FROM AUTHOR]
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- 2024
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36. Cachexia and head and neck squamous cell carcinoma: A scoping review
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Porter, S. R., primary and Ukwas, A., additional
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- 2023
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37. The role of clay minerals in the preservation of Precambrian organic‐walled microfossils
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Woltz, C. R., primary, Anderson, R. P., additional, Tosca, N. J., additional, and Porter, S. M., additional
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- 2023
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38. The Tonian and Cryogenian Periods
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Halverson, G., primary, Porter, S., additional, and Shields, G., additional
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- 2020
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39. The Small Satellites of Pluto
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Porter, S. B., primary
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- 2020
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40. Biogeography and Macroecology of Phorid Flies That Attack Fire Ants in South-Eastern Brazil and Argentina
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Folgarait, P. J., Bruzzone, O., Porter, S. D., Pesquero, M. A., and Gilbert, L. E.
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- 2005
41. Microstructure-mechanical property relationships during the thermomechnaical simulation and annealing of novel interstitial free steels
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Porter, S. L.
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669 - Abstract
Interstitial Free (IF) Steels are widely used in the automotive industry. Their excellent mechanical property characteristics, such as the high formability typified by high r
mean -values, low yield strength and high elongation make them very suitable for manufacturing into automotive body panels. However, their properties and microstructures are affected by their composition and processing conditions. This research program is focused on the optimisation of the properties of two Interstitial Free Steel Grades, an experimentally produced mild Ti-Nb IF Grade and a commercially produced high strength Ti-IF grade. The optimisation of the processing conditions is vital to the enhancement of obtained properties and is investigated in two parts within this research program. The first part will simulate the effect of variable hot rolling parameters on these two grades. This study will aim to investigate the effect of the finishing temperature, effect of run-out table cooling and coiling temperature, all of which are extremely important parameters within the hot mill and may have a significant effect on the microstructure and properties of the two grades. For this work the Gleeble 3500 thermomechanical system has been employed to simulate the hot rolling conditions. The second part will aim to simulate the effect of batch annealing sequences on cold rolled strips of these two grades. This shall aim to determine the optimum annealing conditions to obtain desirable properties on the studied grades. The work demonstrated the differences in microstructure and properties of the two grades investigated, with respect to the simulated processing parameters. It could be observed that the microstructures obtained on these two grades were indeed very different, with the microstructure of the high strength commercial Ti-IF grade consisting of mainly non-equilibrium ferritic and / or bainitic structures, while the microstructure of the mild experimental Ti-Nb IF Grade mainly consisting of recrystallised equiaxed ferrite. Testing of the batch annealed strips, revealed that the rmean -values were very high for both steels, thus permitting a determination of the annealing temperature for which optimum strength and formability values could be obtained.- Published
- 2005
42. Changes in brain-behavior relationships following a 3-month pilot cognitive intervention program for adults with traumatic brain injury
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Porter, S., Torres, I.J., Panenka, W., Rajwani, Z., Fawcett, D., Hyder, A., and Virji-Babul, N.
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- 2017
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43. Poisoning of raptors with organophosphorus and carbamate pesticides with emphasis on Canada, US and UK
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Mineau, P, Fletcher, M R, Glaser, L C, Thomas, N J, Brassard, C, Wilson, L K, Elliott, J E, Lyon, L A, Henny, C J, Bollinger, T, Porter, S L, and BioStor
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- 1999
44. Brk/PTK6 and Involucrin Expression May Predict Breast Cancer Cell Responses to Vitamin D
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Box, C, Pennington, C, Hare, S, Porter, S, Edwards, D, Eccles, S, Crompton, M, and Harvey, A
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breast cancer ,protein tyrosine kinase 6 (PTK6) ,differentiation ,breast tumour kinase (Brk) ,1,25-dihydroxyvitamin D3 ,involucrin - Abstract
Data Availability Statement: No datasets were generated during this study Copyright © 2023 by the authors. The process of human embryonic mammary development gives rise to the structures in which mammary cells share a developmental lineage with skin epithelial cells such as keratinocytes. As some breast carcinomas have previously been shown to express high levels of involucrin, a marker of keratinocyte differentiation, we hypothesised that some breast tumours may de-differentiate to a keratinocyte-derived ‘evolutionary history’. To confirm our hypothesis, we investigated the frequency of involucrin expression along with that of Brk, a tyrosine kinase expressed in up to 86% of breast carcinomas whose normal expression patterns are restricted to differentiating epithelial cells, most notably those in the skin (keratinocytes) and the gastrointestinal tract. We found that involucrin, a keratinocyte differentiation marker, was expressed in a high proportion (78%) of breast carcinoma samples and cell lines. Interestingly, tumour samples found to express high levels of involucrin were also shown to express Brk. 1,25-dihydroxyvitamin D3, a known differentiation agent and potential anti-cancer agent, decreased proliferation in the breast cancer cell lines that expressed both involucrin and Brk, whereas the Brk/involucrin negative cell lines tested were less susceptible. In addition, responses to 1,25-dihydroxyvitamin D3 were not correlated with vitamin D receptor expression. These data contribute to the growing body of evidence suggesting that cellular responses to 1,25-dihydroxyvitamin D3 are potentially independent of vitamin D receptor status and provide an insight into potential markers, such as Brk and/or involucrin that could predict therapeutic responses to 1,25-dihydroxyvitamin D3. This work was supported primarily by project grants from the Breast Cancer Campaign (2006NovPR19 awarded to MRC/SE/AH) and the EU Framework Programme 6 Cancer Degradome project (LSHC-CT-2003-503297). The authors acknowledge NHS funding to the NIHR Biomedical Research Centre.
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- 2023
45. To what extent does vegetation composition and structure influence beetle communities and species richness in private gardens in New Zealand?
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van Heezik, Y., Dickinson, K.J.M., Freeman, C., Porter, S., Wing, J., and Barratt, B.I.P.
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- 2016
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46. Molecular markers relevant to myocardial injury following dental extraction in patients with and without coronary artery disease
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Habbab, K. M., D’Aiuto, F., Habbab, M. A., and Porter, S. R.
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- 2019
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47. Pharmacogenetics of Bisphosphonate-associated Osteonecrosis of the Jaw
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Fung, P.L., Nicoletti, P., Shen, Y., Porter, S., and Fedele, S.
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- 2015
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48. Mutual Orbit Orientations of Transneptunian Binaries
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Grundy, W. M, Noll, K. S, Roe, H. G, Buie, M. W, Porter, S. B, Parker, A. H, Nesvorny, D, Levison, H. F, Benecchi, S. D, Stephens, D. C, and Trujillo, C. A
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Astrophysics - Abstract
We present Keplerian orbit solutions for the mutual orbits of 17 transneptunian binary systems (TNBs). For ten of them, the orbit had not previously been known: 60458 2000 CM (sub 114), 119979 2002 WC (sub 19), 160091 2000 OL (sub 67), 160256 2002 PD (sub 149), 469514 2003 QA (sub 91), 469705 ǂKagara, 508788 2000 CQ (sub 114), 508869 2002 VT (sub 130), 1999 RT (sub 214), and 2002 XH (sub 91). Seven more are systems where the size, shape, and period of the orbit had been published, but new observations have now eliminated the sky plane mirror ambiguity in its orientation: 90482 Orcus, 120347 Salacia-Actaea, 1998 WW (sub 31), 1999 OJ (sub 4), 2000 QL (sub 251), 2001 XR (sub 254), and 2003 TJ (sub 58). The dynamical masses we obtain from TNB mutual orbits can be combined with estimates of the objects' sizes from thermal observations or stellar occultations to estimate their bulk densities. The ǂKagara system is currently undergoing mutual events in which one component casts its shadow upon the other and/or obstructs the view of the other. Such events provide valuable opportunities for further characterization of the system. Combining our new orbits with previously published orbits yields a sample of 35 binary orbits with known orientations that can provide important clues about the environment in which outer solar system planetesimals formed, as well as their subsequent evolutionary history. Among the relatively tight binaries, with semimajor axes less than about 5 percent of their Hill radii, prograde mutual orbits vastly outnumber retrograde orbits. This imbalance is not attributable to any known observational bias. We suggest that this distribution could be the signature of planetesimal formation through gravitational collapse of local density enhancements such as caused by the streaming instability. Wider binaries, with semimajor axes greater than 5 percent of their Hill radii, are somewhat more evenly distributed between prograde and retrograde orbits, but with mutual orbits that are aligned or anti-aligned with their heliocentric orbits. This pattern could perhaps result from Kozai-Lidov cycles coupled with tidal evolution eliminating high inclination wide binaries.
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- 2019
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49. Long-term dynamics of a high-latitude coral reef community at Sodwana Bay, South Africa
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Porter, S. N. and Schleyer, M. H.
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- 2017
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50. The doctoral education context in the twenty-first century: Change at every level
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Grant, B., Nerad, M., Balaban, C., Deem, R., Grund, M., https://orcid.org/0000-0002-1487-8506, Herman, C., Kanjuo Mrčela, A., Porter, S., Rutledge, J., and Strugnell, R.
- Published
- 2022
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