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1. sj-pdf-1-wso-10.1177_17474930211006284 - Supplemental material for Chagas disease is an independent predictor of stroke and death in a cohort of heart failure patients

Author

Cerqueira-Silva, Thiago, Gon��alves, Beatriz MM, Pereira, Camila B, Porto, Louise M, Marques, Maria EL, Santos, Leila SB, Oliveira, Murilo A, F��lix, Iuri F, de Sousa, Paulo RS P, Mui��os, Pedro JR, Maia, Renata M, Catto, Mar��lia B, Andrade, Alisson L, Jesus, Pedro AP, Aras, Roque, and Oliveira-Filho, Jamary

Subjects
FOS: Clinical medicine, Cardiology, Medicine, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-pdf-1-wso-10.1177_17474930211006284 for Chagas disease is an independent predictor of stroke and death in a cohort of heart failure patients by Thiago Cerqueira-Silva, Beatriz MM Gon��alves, Camila B Pereira, Louise M Porto, Maria EL Marques, Leila SB Santos, Murilo A Oliveira, Iuri F F��lix, Paulo RS P de Sousa, Pedro JR Mui��os, Renata M Maia, Mar��lia B Catto, Alisson L Andrade, Pedro AP Jesus, Roque Aras and Jamary Oliveira-Filho in International Journal of Stroke

Published
2022
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2. Chagas disease is an independent predictor of stroke and death in a cohort of heart failure patients

Author

Cerqueira-Silva, Thiago, primary, Gonçalves, Beatriz MM, additional, Pereira, Camila B, additional, Porto, Louise M, additional, Marques, Maria EL, additional, Santos, Leila SB, additional, Oliveira, Murilo A, additional, Félix, Iuri F, additional, de Sousa, Paulo RS P, additional, Muiños, Pedro JR, additional, Maia, Renata M, additional, Catto, Marília B, additional, Andrade, Alisson L, additional, Jesus, Pedro AP, additional, Aras, Roque, additional, and Oliveira-Filho, Jamary, additional

Published
2021
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3. Chagas disease is an independent predictor of stroke and death in a cohort of heart failure patients.

Author

Cerqueira-Silva, Thiago, Gonçalves, Beatriz MM, Pereira, Camila B, Porto, Louise M, Marques, Maria EL, Santos, Leila SB, Oliveira, Murilo A, Félix, Iuri F, de Sousa, Paulo RS P, Muiños, Pedro JR, Maia, Renata M, Catto, Marília B, Andrade, Alisson L, Jesus, Pedro AP, Aras, Roque, and Oliveira-Filho, Jamary

Subjects
HEART failure, CHAGAS' disease, STROKE, HEART failure patients, ARRHYTHMIA, SERODIAGNOSIS, CORONARY artery disease
Abstract

Background and Aims: Chagas disease is a common cause of heart failure (HF) and death in developing countries. Although stroke is known to occur in these patients, an accurate estimate of stroke incidence is lacking. We aimed to determine the incidence of stroke and death in patients with HF, comparing Chagas and non-Chagas etiologies. Methods: Cohort of stroke-free patients with HF (Framingham criteria) followed in a university-based outpatient clinic in Brazil. Baseline characteristics included sociodemographic, risk factor assessment, echocardiographic and electrocardiographic findings. Chagas disease was defined by appropriate serologic tests. Cause-specific Cox regression was used to search for predictors of stroke or death as separate outcomes. Results: We studied 565 patients with HF between January 2003 and December 2018, mean age 54.3 ± 12.9 years, 305 (54.0%) females, 271/535 (50.7%) with Chagas disease. Chagas patients were older (55.5 vs. 53.1 years), more frequently women (60.5% vs. 47.3%), less frequently harbored coronary artery disease (14.5% vs. 34.1%) when compared to non-Chagas patients. Echocardiography showed more severe disease among non-Chagas patients [median left ventricle ejection fraction (LVEF) 37.3% vs. 47.0%]. Over a mean 42.9 (±34.4) months, we followed 404 (71.5%) patients, completing 1442 patient-years of follow-up. Stroke incidence was higher in Chagas when compared to non-Chagas patients (20.2 vs. 13.9 events per 1000 patient-years), while death rate was similar (41.6 vs. 43.1 deaths per 1000 patient-years). In the multivariable analysis for stroke outcome adjusted for LVEF and arrhythmias, cause-specific hazard ratio (CSHR) for Chagas was 2.54 (95% confidence interval 1.01–6.42, p = 0.048). Chagas disease was also associated with increased risk of death (CSHR 1.83; 95% confidence interval 1.04–3.24, p = 0.037). Conclusion: Chagas disease is associated with increased risk of stroke and death when compared to other etiologies of HF, independently of HF severity or cardiac arrhythmias, suggesting other factors contribute to increased stroke risk and mortality in Chagas disease. Early prevention and treatment of Chagas disease is imperative to reduce a later risk of stroke in endemic areas. [ABSTRACT FROM AUTHOR]

Published
2022
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4. Association Between Risk of Obstructive Sleep Apnea and Cerebrovascular Reactivity in Stroke Patients

Author

Castello‐Branco, Renan C., primary, Cerqueira‐Silva, Thiago, additional, Andrade, Alisson L., additional, Gonçalves, Beatriz M. M., additional, Pereira, Camila B., additional, Felix, Iuri F., additional, Santos, Leila S. B., additional, Porto, Louise M., additional, Marques, Maria E. L., additional, Catto, Marilia B., additional, Oliveira, Murilo A., additional, de Sousa, Paulo R. S. P., additional, Muiños, Pedro J. R., additional, Maia, Renata M., additional, Schnitman, Saul, additional, and Oliveira‐Filho, Jamary, additional

Published
2020
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5. Factors associated with abnormal cardiac magnetic resonance imaging in embolic stroke of undetermined source

Author

Neri, Lidianne R, primary, Torreão, Jorge A, additional, Porto, Louise M, additional, Gonçalves, Beatriz MM, additional, Andrade, Alisson L, additional, Pereira, Camila B, additional, Garcia, Karina O, additional, Catto, Marília B, additional, Muinos, Pedro JR, additional, Maia, Renata M, additional, Silva, Thiago C, additional, Jesus, Pedro AP, additional, Rocha-Filho, José A, additional, and Oliveira-Filho, Jamary, additional

Published
2019
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6. Abstract WP219: Chagas Disease is an Independent Risk Factor for Stroke or Death: Long-term Results From a Hospital-based Cohort

Author

Gonçalves, Beatriz M, primary, Oliveira-Filho, Jamary, additional, Andrade, Alisson L, additional, Barreto-Neto, Nestor, additional, Ferreira, Isadora L, additional, Fernandes, Rodrigo D, additional, Reis, Carolina C, additional, Resende, Lucas L, additional, Lordelo, Morgana J, additional, Jesus, Adriano A, additional, Porto, Louise M, additional, Pereira, Camila B, additional, Catto, Marília B, additional, Muiños, Pedro J, additional, Jesus, Pedro A, additional, Reis, Francisco J, additional, Aras, Roque, additional, Fernandes, André M, additional, Filho, Joel A, additional, and Furie, Karen L, additional

Published
2016
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