31 results on '"Porto CL"'
Search Results
2. Comparison between two tests of delayed recall for the diagnosis of dementia
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Takada Leonel Tadao, Caramelli Paulo, Fichman Helenice Charchat, Porto Cláudia Sellitto, Bahia Valéria Santoro, Anghinah Renato, Carthery-Goulart Maria Teresa, Radanovic Márcia, Smid Jerusa, Herrera Jr. Emílio, and Nitrini Ricardo
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dementia ,Alzheimer?s disease ,memory ,neuropsychological tests ,educational status ,illiteracy ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Diagnosis of dementia is a challenge in populations with heterogeneous educational background. OBJECTIVE: To compare the accuracies of two delayed recall tests for the diagnosis of dementia in a community with high proportion of illiterates. METHOD: The delayed recall of a word list from the CERAD battery (DR-CERAD) was compared with the delayed recall of objects presented as line drawings from the Brief Cognitive Screening Battery (DR-BCSB) using ROC curves. Illiterate (23 controls and 17 patients with dementia) and literate individuals (28 controls and 17 patients with dementia) were evaluated in a community-dwelling Brazilian population. RESULTS: The DR-BCSB showed higher accuracy than the DR-CERAD in the illiterate (p=0.029), similar accuracy in the literate individuals (p=0.527), and a trend for higher accuracy in the entire population (p=0.084). CONCLUSION: the DR-BCSB could be an alternative for the diagnosis of dementia in populations with high proportion of illiterates.
- Published
- 2006
3. Inserting the Nuclear Physics theme in high school: deconstructing and building a new look on radioactivity and nuclear energy
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Silva, Gilberg Pereira da, Porto, Cl?udio Maia, Porto, Claudio Maia, Cruz, Frederico Alan de Oliveira da, and Porto, Maria Beatriz Dias da Silva Maia
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Aprendizagem Significativa ,Radioactivity ,Meaningful learning ,Radioatividade ,Active Methodology ,sustentabilidade ,Educa??o ,Metodologia Ativa - Abstract
Submitted by Jorge Silva (jorgelmsilva@ufrrj.br) on 2022-07-14T19:30:37Z No. of bitstreams: 1 2019 - Gilberg Pereira da Silva.pdf Made available in DSpace on 2022-07-14T19:30:37Z (GMT). No. of bitstreams: 1 2019 - Gilberg Pereira da Silva.pdf This dissertation results from a qualitative and quantitative research of a master's degree program in Science and Mathematics Education - PPGEduCIMAT - from the Federal Rural University of Rio de Janeiro - UFRRJ. The research values students' prior knowledge on the topic of Radioactivity and Nuclear Energy, deconstructing and building a new perspective on these two topics of Nuclear Physics, towards a Meaningful Learning. Transcending the view of something deemed purely dangerous is the challenge of topics filled with myths and truths. The objectives were: to show the presence of Nuclear Physics in people's daily lives, demystifying negative concepts stemming from common sense and to create a discussion about common sense, through pedagogical intervention, in order to arouse interest in scientific knowledge. Thus, a Didactic Sequence for Teaching and Learning the contents of Radioactivity and Nuclear Energy was prepared as a final product. The methodology that guided this study was Action Research, tracing paths until acknowledging the use of Active Methodology in the application of the Didactic Sequence. Applied in two classes of a Federal Public School located in the city of Itagua? / RJ and in four classes of a State Public School located in the city of Rio de Janeiro / RJ, the educational product was designed to take place in four moments: at first, entitled ?Arousing curiosity?, the teacher as a researcher acclimates students with a playful activity, makes a diagnostic assessment of the class's opinion regarding the topic of Radioactivity and proposes a challenge to students; in the second moment, called ?breaking taboos?, students become protagonists in the teaching-learning process and present their research on the subject; the third moment was identified as ?creating intimacy with Nuclear Physics? and the teacher as a researcher gives an oral presentation to students with a focus on applications of Nuclear Physics in everyday life; and the fourth moment, named ?stepping on Radioactive soil?, consists of a guided visit to a non-formal teaching space that raises discussions on the topic. The results were surprising, the goal was reached in a pleasant way for both parties. This success happened when the personalization of the teaching, giving autonomy to the students and the protagonism in the process of approaching the themes of Nuclear Physics, reflected in a very significant change regarding the positive view of topics that were not attractive in the past. Esta disserta??o resulta da pesquisa quali-quantitativa de mestrado do Programa de P?s-Gradua??o em Educa??o em Ci?ncias e Matem?tica ? PPGEduCIMAT ? da Universidade Federal Rural do Rio de Janeiro ? UFRRJ. A pesquisa valoriza os conhecimentos pr?vios dos alunos sobre o tema Radioatividade e Energia Nuclear, desconstruindo e construindo um novo olhar sobre esses dois t?picos da F?sica Nuclear, com vistas a uma Aprendizagem Significativa. Transcender a vis?o de algo tido como puramente perigoso ? o desafio de t?picos recheados de mitos e verdades. Foram estabelecidos como objetivos: mostrar a presen?a da F?sica Nuclear no dia a dia das pessoas, desmistificando conceitos negativos oriundos do senso comum e criar uma discuss?o sobre o senso comum, atrav?s de interven??o pedag?gica, a fim de despertar o interesse pelo conhecimento cient?fico. Para isso, foi elaborada, como produto final, uma Sequ?ncia Did?tica para o Ensino e a Aprendizagem dos conte?dos de Radioatividade e Energia Nuclear. A metodologia que norteou este trabalho foi a Pesquisa-A??o, trilhando caminhos at? chegar ? tomada de decis?o do uso da Metodologia Ativa na aplica??o da Sequ?ncia Did?tica. Aplicado em duas turmas de uma Escola P?blica Federal localizada na cidade de Itagua?/RJ e em quatro turmas de uma Escola P?blica Estadual localizada na cidade do Rio de Janeiro/RJ, o produto educacional foi modelado para ocorrer em quatro momentos: no primeiro, intitulado ?despertando a curiosidade?, o professor pesquisador ambienta os alunos com uma atividade l?dica, faz uma avalia??o diagn?stica sobre a opini?o da turma em rela??o ao tema Radioatividade e prop?e um desafio aos educandos; no segundo momento, denominado ?derrubando tabus?, os alunos se tornam protagonistas no processo de ensino-aprendizagem e apresentam suas pesquisas sobre o assunto; o terceiro momento foi denominado ?criando intimidade com a F?sica Nuclear? e o professor pesquisador faz uma exposi??o oral para os estudantes com foco em aplica??es da F?sica Nuclear no cotidiano; e o quarto momento, chamado ?pisando em solo Radioativo? ? composto por uma visita guiada a um espa?o n?o-formal de ensino que suscite discuss?es sobre o tema. Os resultados foram surpreendentes, a meta foi alcan?ada de forma agrad?vel para ambas as partes. Esse sucesso aconteceu quando a personaliza??o do ensino, dando autonomia aos alunos e o protagonismo no processo de abordagem dos temas de F?sica Nuclear, refletiu em uma mudan?a bastante significativa no que se refere a vis?o positiva de t?picos nada atrativos no passado.
- Published
- 2019
4. From concrete to abstract: building basic concepts in Physics
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Machado, Nat?lia Alves, Cruz, Frederico Alan de Oliveira, Porto, Cl?udio Maia, and Medeiros Junior, Luciano Gomes de
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Abstrato ,Physics ,Conceitos Basilares ,Basic Concepts ,Concreto ,Ensino de Ci?ncias e Matem?tica ,F?sica ,Abstract ,Concrete - Abstract
Submitted by Jorge Silva (jorgelmsilva@ufrrj.br) on 2018-06-13T18:25:28Z No. of bitstreams: 1 2017 - Nat?lia Alves Machado.pdf: 3771402 bytes, checksum: 7e4676cbdd43a00d5d92a31b0864721c (MD5) Made available in DSpace on 2018-06-13T18:25:28Z (GMT). No. of bitstreams: 1 2017 - Nat?lia Alves Machado.pdf: 3771402 bytes, checksum: 7e4676cbdd43a00d5d92a31b0864721c (MD5) Previous issue date: 2017-02-10 A large amount of students come to high school having great difficulties to understand the basics Physics contents, precisely because they did not truly understand the basics concepts, such as the elementary operations and etc. It turns into be one of the biggest challenges faced by us, the teachers, in the classroom, who seek to make classes attractive and meaningful for the students learning process. In the search to make the process more cooperative, that is to say, by having students actively participating in the discussion of themes several techniques have been developed. In this paper, we will discuss some fundamental concepts in Physics ? magnitudes and its measurement units, length, ratio and proportion, area and volume ? in the attempt to investigate how students understand these concepts and how some tangible activities done inside the classroom with students of any school year help them to set more advanced and abstracts Physics concepts. Elaborating simple and concrete material brings many possibilities either for students or for teachers. With the handling and experimentation of these materials, students will understand the basic phenomena associated to it, so teachers could rethink their own lessons, in addition to discuss with the students how they need to go through the concrete ?thought? so they can think of the magnitudes in a more abstract way, which we do, in most cases, in Physics teaching. Thereby this paper exposes a wide-ranging discussion about the need and the importance of the concrete to improve students learning in order to enhance classes, stimulate the students and enable them to be able to appropriate the themes that are presented to them in Physics. Muitos alunos chegam ao Ensino M?dio com uma grande dificuldade de entender os conte?dos b?sicos de F?sica, justamente por n?o terem aprendido de maneira concreta os conceitos b?sicos, como por exemplos as unidades de medidas, as opera??es b?sicas etc. Isto acaba se tornando um dos maiores desafios enfrentados por n?s, professores, nas salas de aula, que buscamos tornar as aulas atrativas e significativas para a aprendizagem dos alunos. Na busca por tornar o processo mais colaborativo, isto ?, fazendo com que os alunos participem da discuss?o dos temas, muitas t?cnicas t?m sido desenvolvidas. Neste trabalho ser?o discutidos alguns conceitos basilares em F?sica? grandezas e suas unidades de medidas, comprimento, raz?o e propor??o, ?rea e volume - na tentativa de investigar como os alunos compreendem esses conceitos e como algumas atividades concretas realizadas em sala de aula, com alunos de qualquer ano escolar, ajudam a formar conceitos mais avan?ados e abstratos da F?sica. Elaborar materiais concretos simples traz muitas possibilidades, tanto para alunos quanto para os professores. Com a manipula??o e experimenta??o desses, os alunos compreender?o os fen?menos b?sicos envolvidos, j? os professores poder?o repensar suas aulas, al?m de discutir como os alunos necessitam passar pelo ?pensamento? concreto para ent?o conseguir pensar nas grandezas de forma mais abstrata, o que fazemos, na maior parte das vezes, no Ensino de F?sica. Deste modo, pretende-se expor uma ampla discuss?o sobre a necessidade e import?ncia do concreto para melhorar a compreens?o dos alunos, com o intuito de melhorar as aulas, estimular os alunos e fazer com que esses sejam capazes de se apropriar dos temas que s?o apresentados a eles na F?sica.
- Published
- 2017
5. Socio-historical representations of a disease: a study of posters from campaigns against Hansen's disease during the second half of the twentieth century.
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Porto CL and Marques MCDC
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- History, 20th Century, Brazil, Humans, Posters as Topic, Health Promotion history, Public Health history, Health Education history, Leprosy history, Leprosy prevention & control
- Abstract
This article analyzes the use of iconographic sources in the context of educational campaigns to combat Hansen's disease from a socio-historical perspective at four points in time: the 1950s, 1960s, 1980s, and 1990s. Four posters are analyzed to identify the elements (textual, visual or graphic) used to develop discourse on this disease and those it affected and transformations and permanences in this discourse, as well as to verify how they became part of a narrative of institutional memory linked to public health in the state of São Paulo. These were produced by various public health institutions and are part of the Health Campaign Poster Collection held by the Emílio Ribas Public Health Museum.
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- 2023
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6. Synthesis of antibacterial composite coating containing nanocapsules in an atmospheric pressure plasma.
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Wang L, Porto CL, Palumbo F, Modic M, Cvelbar U, Ghobeira R, De Geyter N, De Vrieze M, Kos Š, Serša G, Leys C, and Nikiforov A
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- Animals, Anti-Bacterial Agents pharmacology, Atmospheric Pressure, Coated Materials, Biocompatible pharmacology, Escherichia coli, Mice, Staphylococcus aureus, Nanocapsules
- Abstract
Antibacterial coating is an important strategy preventing bacterial colonization and biofilm formation. One-step synthesis of nanocapsule-containing antibacterial coatings with controlled release of Ag
+ ions was achieved in the current work by aerosol-assisted atmospheric pressure plasma deposition. The experimental parameters of deposition including the discharge power, silver nitrate concentration, aerosol flow rate, continuous and pulsed mode of operation were studied in order to analyze their effects on surface morphology and chemical composition of the coating. Formation of nanocapsules embedded in the polymeric coating was observed. A core-shell structure was found for nanocapsule with silver in the core and polymer in the shell. Antibacterial coatings on polyethylene terephthalate film were studied in terms of Ag+ ion release, antibacterial properties against Escherichia coli and Staphylococcus aureus, and cytotoxicity with murine fibroblasts. Two-phase release kinetics of Ag+ ions was observed as initially a short-term burst release followed by a long-term slow release. It was revealed that high antibacterial efficiency of the coatings deposited on polyethylene terephthalate films can be coupled with low cytotoxicity. These biocompatible antibacterial coatings are very promising in different fields including biological applications., (Copyright © 2020 Elsevier B.V. All rights reserved.)- Published
- 2021
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7. [Writing about oneself and a disease: a study on biographical and autobiographical work by survivors of Hansen's disease].
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Porto CL
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This article investigates some elements of representation in literary work based on memoirs of people with Hansen's disease (formerly known as leprosy) who lived the confinement forced upon people with this disease in Brazil until the mid-1980s. In addition to the stigma associated with leprosy, this policy traumatized patients, who faced social exclusion and loss of relationships; these experiences yielded autobiographies, biographies, and even romances inspired by their memories of life in isolation. Our objective is to understand, through the study of some of these records, how these people saw themselves and how they viewed the disease and their places of confinement.
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- 2019
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8. Single step synthesis of Janus nano-composite membranes by atmospheric aerosol plasma polymerization for solvents separation.
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Chen X, Porto CL, Chen Z, Merenda A, Allioux FM, d'Agostino R, Magniez K, Dai XJ, Palumbo F, and Dumée LF
- Abstract
Solvent permeation across membranes is limited due to physical resistance to diffusion from the selective layer within the membrane and to plasticizing effects generated by the solvent molecules onto the polymeric macromolecular matrix. Nano-composite thin film membranes provide promising routes to generate controlled microstructural separation materials with higher selectivities and permeabilities. Here, the fabrication of nano-composite based on octamethyl-polyhedral oligomeric silsesquioxane - hexamethyldisiloxane thin film membranes is demonstrated by aerosol assisted atmospheric plasma deposition onto pre-formed nano-porous membrane supports for the first time. Stable, atomically smooth and continuous solid films with controllable thickness down to 50 nm were achieved. The deposition process allowed for the control of the wettability of the surfaces to water and organic solvents, leading to the generation of hydrophobic but alcohol-philic surfaces. The liquid entry pressure of the films to water was found to be 8 bar from plasma polymerization as oppose to 3 bar for the bare nano-porous support only. In addition, the ideal separation selectivity for ethanol to water, up to 6.5, highlight the impact of both the surface energy and level of cross-linking of the hexamethyldisiloxane nanostructures on the diffusion mechanisms. This new atmospheric plasma deposition strategy opens-up cost-effective and environmentally friendly routes for the design of the smart Janus membrane with customizable properties and performance., (Copyright © 2018 Elsevier B.V. All rights reserved.)
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- 2018
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9. Aberrant DNA methylation patterns of human spermatozoa in current smoker males.
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Laqqan M, Tierling S, Alkhaled Y, Porto CL, Solomayer EF, and Hammadeh ME
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- Adult, CpG Islands, Humans, Male, Middle Aged, Smokers, Smoking genetics, Smoking metabolism, DNA Methylation, Smoking adverse effects, Spermatozoa metabolism
- Abstract
The purpose of this study was to investigate the impact of current cigarette smoking on sperm DNA methylation patterns. A total of 108 males (51 current smokers and 57 never smoked males) were included in the study. Using 450 BeadChip Arrays, the differentially methylated CpGs between current smokers (n=15) and never smoked males (n=15) were identified. Out of significantly 11 CpGs identified, 2 CpGs namely cg07869343 and cg19169023, which are located in the MAPK8IP3 and TKR genes were selected for further analysis. Using deep bisulfite sequencing in an independent cohort of current smokers (n=36) and never smoked males (n=42), 6 and 1 CpGs showed a significant difference in the MAPK8IP (CpG3, CpG5, CpG6, CpG7, CpG8, and CpG21) and in the TKR (CpG4) were identified, respectively (P≤0.05). Our results indicate that cigarette smoking causes biochemical changes in the sperm DNA methylation in many regions and could adversely affect semen parameters., (Copyright © 2017 Elsevier Inc. All rights reserved.)
- Published
- 2017
- Full Text
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10. Altered expression of histone deacetylases in cancer.
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Montezuma D, Henrique RM, and Jerónimo C
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- Animals, Gene Expression Regulation, Enzymologic, Gene Expression Regulation, Neoplastic, Histone Deacetylase Inhibitors pharmacology, Histone Deacetylase Inhibitors therapeutic use, Histone Deacetylases physiology, Humans, Neoplasms therapy, Sirtuins physiology, Histone Deacetylases genetics, Neoplasms genetics
- Abstract
Epigenetic mechanisms, including histone deacetylation, are commonly deregulated in cancer. Histone deacetylases (HDACs) play an important role in tumorigenesis and their value as therapeutic targets has been under intense investigation in recent years. In addition to classical HDACs (HDAC classes I, II, and IV), sirtuins (class III HDACs) are currently in the spotlight of cancer research showing promise as cancer biomarkers and therapeutic targets. Translating research knowledge into the clinical setting is, however, a challenging and demanding task. This review describes the association between HDAC deregulation and cancer promotion and highlights recent advances in the use of HDAC inhibitors in the management of neoplastic diseases, with emphasis on urological tumors. Sirtuins' bivalent role in tumor development and therapeutic agents targeting these molecules will be also addressed.
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- 2015
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11. Hybrid layer thickness and morphology: Influence of cavity preparation with air abrasion.
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Barceleiro MO, de Mello JB, Porto CL, Dias KR, and de Miranda MS
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- Composite Resins chemistry, Dental Cavity Preparation instrumentation, Dental High-Speed Equipment, Dental Materials chemistry, Dental Polishing methods, Diamond chemistry, Humans, Materials Testing, Microscopy, Electron, Scanning, Surface Properties, Air Abrasion, Dental methods, Dental Bonding methods, Dental Cavity Preparation methods, Dentin ultrastructure, Dentin-Bonding Agents chemistry, Resin Cements chemistry
- Abstract
Dentinal surfaces prepared with air abrasion have considerably different characteristics from those prepared with conventional instruments. Different hybrid layer morphology and thickness occur, which can result in differences in the quality of restorations placed on dentinal surfaces prepared with a diamond bur compared to surfaces prepared using air abrasion. The objective of this study was to compare the hybrid layer thickness and morphology formed utilizing Scotchbond Multi-Purpose Plus (SBMP) on dentin prepared with a diamond bur in a high-speed handpiece and on dentin prepared using air abrasion. Flat dentin surfaces obtained from five human teeth were prepared using each method, then treated with the dentin adhesive system according to manufacturer's instructions. After a layer of composite was applied, specimens were sectioned, flattened, polished, and prepared for scanning electron microscopy. Ten different measurements of hybrid layer thickness were obtained along the bonded surface in each specimen. SBMP produced a 3.43 ± 0.75 µm hybrid layer in dentin prepared with diamond bur. This hybrid layer was regular and found consistently. In the air abrasion group, SBMP produced a 4.94 ± 1.28 µm hybrid layer, which was regular and found consistently. Statistical ANOVA (P = 0.05) indicated that there was a statistically significant difference between the groups. These data indicate that the air abrasion, within the parameters used in this study, provides a thick hybrid layer formation.
- Published
- 2011
12. Changes on venous diameter and leg perimeter with different clinical treatments for moderate chronic venous disease: evaluation using Duplex scanning and perimeter measurements.
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Porto CL, Milhomens AL, Pires CE, Xavier SS, Sicuro F, Bottino DA, and Bouskela E
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- Adult, Ascorbic Acid adverse effects, Brazil, Cardiovascular Agents adverse effects, Chi-Square Distribution, Chronic Disease, Chymotrypsin adverse effects, Disability Evaluation, Drug Combinations, Female, Hesperidin adverse effects, Humans, Middle Aged, Pain etiology, Pain prevention & control, Pain Measurement, Phytosterols adverse effects, Time Factors, Treatment Outcome, Trypsin adverse effects, Vascular Diseases complications, Vascular Diseases diagnostic imaging, Vascular Diseases pathology, Anthropometry instrumentation, Ascorbic Acid therapeutic use, Cardiovascular Agents therapeutic use, Chymotrypsin therapeutic use, Hesperidin therapeutic use, Lower Extremity blood supply, Lower Extremity pathology, Phytosterols therapeutic use, Popliteal Vein diagnostic imaging, Saphenous Vein diagnostic imaging, Stockings, Compression, Trypsin therapeutic use, Ultrasonography, Doppler, Duplex, Vascular Diseases therapy
- Abstract
Aim: To evaluate changes on venous diameter and perimeter of lower limbs in chronic venous disorder (CVD) patients after different clinical treatments for four weeks., Methods: Fifty-two female patients classified as C2,s or C2,3,s (CEAP classification) were allocated consecutively in three groups: Cirkan (40 mg of the root extract of Ruscus aculeatus + 100 mg of flavonoid hesperidine methylchalcone + 200 mg of vitamin C per pill); elastic compression stockings (ECS) and no treatment (NT). Diameters were determined by duplex ultrasound and perimeter with Leg-O-Meter., Results: After treatment, Cirkan significantly decreased popliteal vein and great saphenous vein (GSV) diameters bilaterally and ECS decreased popliteal vein diameter bilaterally and GSV and varices only on the left limb. Perimeters changed only with ECS. Clinical scores changed between Cirkan x NT and ECS x Cirkan. Disability score varied for ECS x NT and Cirkan x NT. chi2 test detected different distribution frequency for C3 and C2 classes according to treatment: ECS (both limbs) and Cirkan (only left limb). Varices and anatomical scores did not change., Conclusions: ECS emerges as the most effective clinical treatment tested but improvements with Cirkan on vein diameter and CEAP class were also observed. Clinical scores improved due to pain relief and edema reduction (ECS). These findings point to a positive effect of Cirkan, suggesting that venotonic drugs should be taken into account in the treatment of CVD.
- Published
- 2009
13. Effect of zinc supplementation on the antioxidant, copper, and iron status of physically active adolescents.
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de Oliveira Kde J, Donangelo CM, de Oliveira AV Jr, da Silveira CL, and Koury JC
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- Adolescent, Anthropometry, Homeostasis drug effects, Humans, Male, Nutritional Status drug effects, Testosterone blood, Antioxidants metabolism, Copper metabolism, Dietary Supplements, Exercise physiology, Iron metabolism, Zinc administration & dosage, Zinc pharmacology
- Abstract
Puberty associated with intense physical activity results in oxidation stress. Zinc supplementation may benefit antioxidant capacity although it may also affect iron and copper status. This study evaluated the effect of zinc supplementation on antioxidant, zinc and copper status of physically active male football players (13 years +/- 0.4 years), divided in two groups and studied during 12 weeks: Zn-supplemented (Zn-SUP, 22 mg Zn d(-1) as zinc gluconate, n = 21) and placebo (PLA, n = 26). At baseline, there was no significant difference in biochemical indices between the two groups. After treatment, plasma zinc and erythrocyte iron increased in both groups (p < 0.001); urinary zinc increased (p < 0.001) only in Zn-SUP, and erythrocyte zinc decreased (p = 0.002) only in PLA. Plasma iron and copper decreased (p = 0.01 and p = 0.015, respectively) only in Zn-SUP. Plasma ferric-reducing ability and plasma conjugated dienes increased, and erythrocyte osmotic fragility decrease in both groups, although the latter two were significantly lower in Zn-SUP compared to PLA (p < 0.01). In conclusion, our study indicates that the use of 22 mg d(-1) of supplemental zinc during 12 week in adolescent athletes did not affect growth, improved markers of antioxidant status but reduced plasma iron and copper. Therefore, it appears that the use of zinc supplementation by healthy adolescent athletes benefits their antioxidant capacity but impairs copper and iron nutritional status., (2009 John Wiley & Sons, Ltd.)
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- 2009
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14. Use of microcirculatory parameters to evaluate clinical treatments of chronic venous disorder (CVD).
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Lascasas-Porto CL, Milhomens AL, Virgini-Magalhães CE, Fernandes FF, Sicuro FL, and Bouskela E
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- Adult, Ascorbic Acid therapeutic use, Capillaries pathology, Capillaries physiopathology, Chymotrypsin therapeutic use, Combined Modality Therapy, Drug Combinations, Edema pathology, Edema therapy, Female, Hesperidin therapeutic use, Humans, Leg pathology, Leg physiopathology, Middle Aged, Phytosterols therapeutic use, Plant Extracts therapeutic use, Stockings, Compression, Treatment Outcome, Trypsin therapeutic use, Venous Insufficiency pathology, Venous Thrombosis pathology, Venous Thrombosis therapy, Microcirculation physiopathology, Venous Insufficiency physiopathology, Venous Insufficiency therapy
- Abstract
Objectives: To evaluate changes on cutaneous microangiopathy in chronic venous disorder (CVD) after use of Cirkan [venotonic drug containing Ruscus aculeatus (plant extract), hesperidine methylchalcone (flavonoid) and vitamin C], elastic compression stockings (ECS) or no treatment for four weeks., Patients and Methods: Fifty-five female patients (85 legs), 25 to 57 years, with at least one limb classified as C2,s or C2,3,s (CEAP classification), were allocated consecutively, according to entrance order, in these three groups. Ten healthy women age-matched were also investigated. Using orthogonal polarization spectral technique (noninvasive method), measurements of functional capillary density (FCD, number of capillaries with flowing red blood cells/mm(2)), capillary morphology (CM, % of abnormal capillaries/mm(2)) and diameters (mum) of dermal papilla (DDP), capillary bulk (DCB) and capillary limb (CD) were obtained on the medial perimalleolar region and later analyzed using CapImage software., Results and Conclusions: CVD patients showed significant changes on CD and CM compared to healthy subjects in agreement with our previous findings (J Vasc Surg 43:1037-1044, 2006). On Cirkan-treated patients, after 4 weeks, CD decreased on both limbs and CM improved on the left one, suggesting an amelioration of the chronic venous hypertension. No significant changes could be detected on other patient groups. These results confirm the existence of microcirculatory dysfunction in early stages of CVD, probably due to post-capillary hypertension, and further support the venotonic action of Cirkan.
- Published
- 2008
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15. Use of microcirculatory parameters to evaluate chronic venous insufficiency.
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Virgini-Magalhães CE, Porto CL, Fernandes FF, Dorigo DM, Bottino DA, and Bouskela E
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- Adult, Blood Flow Velocity physiology, Capillaries physiopathology, Chronic Disease, Female, Humans, Image Processing, Computer-Assisted, Leg blood supply, Microcirculation physiopathology, Middle Aged, Observer Variation, Robotics, Software, Statistics as Topic, Venous Insufficiency classification, Venous Insufficiency diagnosis, Venous Thrombosis classification, Venous Thrombosis diagnosis, Venous Thrombosis physiopathology, Skin blood supply, Venous Insufficiency physiopathology
- Abstract
Background: Microcirculatory impairment caused by chronic venous hypertension is usually not taken into account in chronic venous insufficiency, probably due to lack of practical means to observe it. The objective of this work was to use a new noninvasive technique to access quantitatively the cutaneous microangiopathy in female patients classified according to CEAP from C1 to C5 and matched with healthy controls., Methods: Forty-four patients and 13 healthy subjects (112 lower limbs), with a mean age +/- SD of 48 +/- 8 years, were evaluated by using orthogonal polarization spectral (OPS) imaging. Films of the internal perimaleolar region were analyzed by the CapImage software. The microcirculatory parameters evaluated were functional capillary density (number of capillaries with flowing red blood cells/mm), capillary morphology (percentage of abnormal capillaries), diameter (microm) of dermal papilla to quantify edema, diameter of capillary bulk (microm) to assess the degree of change, and diameter capillary limb to detect enlargement. A microcirculatory index combining these five parameters was proposed with I, II, and III stages, indicating normal microcirculation, and moderate and severe microangiopathy, respectively., Results: These microcirculatory parameters were significantly different (P < .05) from control values (C): capillary diameter and capillary morphology from C2 to C5, 8.1 +/- 0.8, 3.6 +/- 5.5 (C), and 9.7 +/- 1.3, 27.5 +/- 17.7 (C2); diameter of dermal papilla and diameter of capillary bulk from C3 to C5, 111.4 +/- 13.5, 52.8 +/- 8.8 (C), and 150.5 +/- 31.7, 87.8 +/- 26.9 (C3); and functional capillary density only from C4 to C5, 20.9 +/- 6.1 (C) and 14.5 +/- 4.5 (C4). The microcirculatory index showed good correlation to CEAP classification., Conclusion: It was possible to quantify the microangiopathy using OPS imaging and to compare the microcirculatory changes of chronic venous insufficiency patients with healthy controls. Two parameters seemed more important to identify the differences between patients and controls: capillary morphology and capillary diameter. The suggested microcirculatory index can possibly demonstrate, in future studies, a prognostic capability when combined with the CEAP classification.
- Published
- 2006
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16. Distribution of lead in human milk fractions: relationship with essential minerals and maternal blood lead.
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Anastácio Ada S, da Silveira CL, Miekeley N, and Donangelo CM
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- Adult, Biological Availability, Brazil, Calcium analysis, Calcium, Dietary administration & dosage, Caseins analysis, Copper analysis, Female, Glycolipids analysis, Glycoproteins analysis, Humans, Iron analysis, Lactation, Lead blood, Lipid Droplets, Milk Proteins analysis, Nutritional Status, Whey Proteins, Zinc analysis, Lead analysis, Milk, Human chemistry
- Abstract
The purpose of this study was to determine the concentration and distribution of lead, calcium, iron, zinc, and copper in major fractions (fat, casein, whey) of mature milk from 38 nursing adult women with low environmental lead exposure. The potential associations between milk lead and maternal blood lead and between milk and blood lead and essential mineral data (nutritional status, dietary intake, and milk concentration) were investigated. Maternal blood lead (geometric mean, 60 microg/L) was negatively associated, although modestly, with dietary calcium intake (r=-0.32, p=0.02). Lead in whole milk (geometric mean, 1.2 microg/L) was positively associated with calcium in whole milk (r=0.56, p=0.005). Distribution of lead in milk fractions was 63%, 28%, and 9%, in whey, fat, and casein, respectively. Milk distribution of essential minerals was 67-76%, 17-18%, and 7-17% in whey, fat, and casein, respectively. Lead in milk whey was positively associated with lead in maternal blood (r=0.49, p=0.02). However, milk lead was not affected by nutritional status, dietary intake, and milk composition of the essential minerals. The high percentage of lead in the milk whey fraction, as seen for the essential minerals, suggests that most lead in human milk is bioavailable to the infant.
- Published
- 2004
- Full Text
- View/download PDF
17. Multi-element analysis of saline matrices by inductively coupled plasma mass spectrometry following on-line preconcentration using a knotted reactor.
- Author
-
Silva FA, da Silveira CL, Miekeley N, and Kuechler IL
- Abstract
A versatile preconcentration system for trace element determination by ICPMS was developed. It is composed of a commercial flow injection analysis system (FIAS) retrofitted with a home-made control unit containing three solenoid valves and working concomitantly with the FIAS, permitting selection and segmentation of sample, reagent, washing solution and elution flow. The knotted reactor used had a length of 200 cm and was made from 0.05 cm i.d. PTFE tubing. The method applies ammonium 1-pyrrolidinedithiocarbamate (APDC) as complexant, allowing the preconcentration and quantitative multi-element determination of Cu, Ni, V, Co, Nb, Mo, In, Sb and Bi. Ethanol and 4-methyl-2-pentanone were tested as eluents. Recovery tests using complex matrices and spike concentrations of 200 ng L(-1) showed typical values in the range of 90% to 110%. Relative standard deviations were < 7% for elution with ethanol and < 5% with methyl isobutyl ketone. For simulated freshwater samples using 4-methyl-2-pentanone as an eluent, a sample loading rate of 5.0 ml min(-1), and a preconcentration time of 60 s, detection limits (ng L(-1)) were in the range of 0.02 (Bi) to 30 (Cu). Under these conditions, analytical frequency was about 15 samples per hour. The feasibility of the method was demonstrated by the succesful analysis of wastewater and seawater certified reference materials.
- Published
- 2004
- Full Text
- View/download PDF
18. [Factors associated with perinatal morbidity and mortality in a sample of public and private maternity centers in the City of Rio de Janeiro, 1999-2001].
- Author
-
Leal Mdo C, Gama SG, Campos MR, Cavalini LT, Garbayo LS, Brasil CL, and Szwarcwald CL
- Subjects
- Adolescent, Adult, Brazil epidemiology, Chi-Square Distribution, Female, Health Services Accessibility statistics & numerical data, Hospitals, Maternity standards, Hospitals, Private standards, Hospitals, Public standards, Humans, Infant, Low Birth Weight, Infant, Newborn, Male, Patient Satisfaction, Pregnancy, Prenatal Care standards, Quality of Health Care standards, Socioeconomic Factors, Hospital Mortality, Hospitals, Maternity statistics & numerical data, Hospitals, Private statistics & numerical data, Hospitals, Public statistics & numerical data, Infant Mortality
- Abstract
This study compares socio-demographic factors, mothers' biological characteristics, and quality of care at maternity hospitals in the City of Rio de Janeiro, Brazil. A sample of 10,072 post-partum women in 47 hospitals was selected. Data were collected by interviewing mothers in the immediate post-partum and from medical records. The chi2 test was used to analyze homogeneity of ratios. Significant differences were found between patients in public and private hospitals in relation to family support, healthy habits during pregnancy, reproductive history, access to and satisfaction with prenatal care and delivery, and particularly adverse effects in the newborns. Private maternity hospitals showed better results, although they displayed excessive cesarean and neonatal inter-hospital transfer rates. The stratum consisting of public Federal and State maternity hospitals received women with greater morbidity, had lower neonatal transfer rates, and received a more positive assessment by clients of the Unified National Health System (SUS). Private maternity centers contracted out by the SUS were the ones that most refused treatment to patients, leading to delays in patient care for delivery.
- Published
- 2004
- Full Text
- View/download PDF
19. [Comparative study of tensile strength of enamel/resin/metal interface. Effect of bonding resins, retention mechanisms and metal alloys].
- Author
-
Camparis Bussadori CM and de Angelis Porto CL
- Subjects
- Aluminum Oxide, Cuspid, Denture, Partial, Fixed, Humans, Materials Testing instrumentation, Phosphates, Resins, Synthetic, Surface Properties, Tensile Strength, Chromium Alloys, Dental Bonding, Resin Cements
- Abstract
The purpose of this study was to compare the enamel/resin/metal bond tensile strength by using human canines, in which castings were bonded. These castings were obtained by Co-Cr or Ni-Cr alloys and showed four types of mechanisms of retention: 50 micrograms aluminum oxide abrasive, electrochemical etch, acrylic beads metal mesh. The castings were bonded utilizing Comspan Opaque and Panavia Ex. The specimens were subjected to tensile forces after 24 hours in an Instron machine. The castings subjected to 50 micrograms aluminum oxide abrasive and bonded utilizing Panavia EX showed the biggest bond tensile strength.
- Published
- 1990
20. [Traction resistance limit of dental amalgam. Effect of inclusion of a silver plate or wire and time].
- Author
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da Fonseca Barbosa AR, Dinelli W, Gabrielli F, Fontana UF, de Angelis Porto CL, and Machado Candido MS
- Subjects
- Dental Stress Analysis, Time Factors, Dental Amalgam, Silver
- Published
- 1986
21. [The translucence of composite resins (I). Effect of material, time and proportion of opacifier pastes].
- Author
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de Medeiros Rocha I, Fernando Fontana U, Gabrielli F, Dinelli W, and de Angelis Porto CL
- Subjects
- Electrophoresis, Light, Optics and Photonics, Time Factors, Composite Resins analysis
- Published
- 1984
22. [Corrosion resistance of copper-aluminum alloys. Study with apparent reflectance and microscopic evaluation. II--Effect of alloys, polishing agents and time].
- Author
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Lauar S, Dinelli W, Gabrielli F, dos Santos MS, and de Angelis Porto CL
- Subjects
- Aluminum, Copper, Corrosion, Dental Alloys analysis, Dental Polishing
- Published
- 1987
23. [Corrosion resistance of copper-aluminum alloys (I). Study on apparent reflectance and microscopic analysis. 1. Effect of type of alloy, conditions and times].
- Author
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dos Santos MS, Reis MS, Dinelli W, Gabrielli F, Fernando Fontana U, and de Angelis Porto CL
- Subjects
- Corrosion, Gold Alloys, Aluminum, Copper, Dental Alloys analysis
- Published
- 1987
24. [Determining factors of clinical success in bonding].
- Author
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Fontana UF, Dinelli W, Gabrielli F, de Angelis Porto CL, and Dos Santos MS
- Subjects
- Composite Resins, Humans, Dental Bonding, Tooth Fractures therapy
- Published
- 1986
25. [Seminar on fixed prosthodontics].
- Author
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Fonseca Brunetti R, José de Paiva H, Ribeiro de Faria I, de Angelis Porto CL, Ramalho de Castro MP, Antonio Bottino M, Mugica Mutti N, Chiapinotto GA, Cabral AJ, and de Andrada MA
- Subjects
- Crowns, Dental Alloys, Dental Cavity Preparation, Denture Design, Humans, Periodontal Prosthesis, Denture, Partial, Fixed
- Published
- 1988
26. [Comparative study of precision of impression materials. Effect of technic, time, and distance].
- Author
-
Nóbrega RA, Angelis Porto CL, Mandarino F, and Candido MS
- Subjects
- Dental Impression Technique, Time Factors, Dental Impression Materials
- Published
- 1987
27. [Presentation and clinical evaluation of a technic of anterior tooth restoration with vestibular enamel facets adapted from extracted teeth].
- Author
-
Fontana UF, Gabrielli F, Dinelli W, de Angelis Porto CL, and Machado Candido MS
- Subjects
- Cuspid, Humans, Incisor, Root Canal Therapy, Tissue Banks, Tooth Diseases therapy, Tooth Extraction, Dental Bonding methods, Dental Enamel, Esthetics, Dental
- Published
- 1987
28. [Alternative copper-aluminum alloys. Study of traction resistance. Effect of alloys on soldering].
- Author
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Cardoso SH, de Angelis Porto CL, Machado Candido MS, and de Porto Neto S
- Subjects
- Aluminum, Copper, Dental Stress Analysis, Dental Alloys, Dental Soldering
- Published
- 1988
29. [Polishing of dental amalgam. Effect of polishing and type of alloy].
- Author
-
Roxo Piccin DC, Gabrielli F, de Angelis Porto CL, Fernando Fontana U, and Machado Candido MS
- Subjects
- Hardness, Dental Amalgam, Dental Polishing methods
- Published
- 1987
30. [Tensile strength of the silicate cements: comparative study using the classic and diametral methods].
- Author
-
Steagall L, Müench A, and Porto CL de A
- Subjects
- Dental Stress Analysis, Silicate Cement standards
- Published
- 1969
31. [Class 3 cavities. Preparation technic].
- Author
-
Gabrielli F, Fontana UF, and Angelis Porto CL
- Subjects
- Dental Cavity Preparation, Dentistry
- Published
- 1971
Catalog
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