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Your search keyword '"Posner, David A."' showing total 234 results
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234 results on '"Posner, David A."'

1. Venous-plexus-associated lymphoid hubs support meningeal humoral immunity

Author

Fitzpatrick, Zachary, Ghabdan Zanluqui, Nagela, Rosenblum, Jared S., Tuong, Zewen Kelvin, Lee, Colin Y. C., Chandrashekhar, Vikram, Negro-Demontel, Maria Luciana, Stewart, Andrew P., Posner, David A., Buckley, Monica, Allinson, Kieren S. J., Mastorakos, Panagiotis, Chittiboina, Prashant, Maric, Dragan, Donahue, Danielle, Helmy, Adel, Tajsic, Tamara, Ferdinand, John R., Portet, Anais, Peñalver, Ana, Gillman, Eleanor, Zhuang, Zhengping, Clatworthy, Menna R., and McGavern, Dorian B.

Published
2024
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3. Tumour-retained activated CCR7+ dendritic cells are heterogeneous and regulate local anti-tumour cytolytic activity.

Author

Lee, Colin Y. C., Kennedy, Bethany C., Richoz, Nathan, Dean, Isaac, Tuong, Zewen K., Gaspal, Fabrina, Li, Zhi, Willis, Claire, Hasegawa, Tetsuo, Whiteside, Sarah K., Posner, David A., Carlesso, Gianluca, Hammond, Scott A., Dovedi, Simon J., Roychoudhuri, Rahul, Withers, David R., and Clatworthy, Menna R.

Subjects
DENDRITIC cells, CYTOTOXIC T cells, T cells, ANTIGEN presentation, LYMPH nodes, CELL migration
Abstract

Tumour dendritic cells (DCs) internalise antigen and upregulate CCR7, which directs their migration to tumour-draining lymph nodes (dLN). CCR7 expression is coupled to an activation programme enriched in regulatory molecule expression, including PD-L1. However, the spatio-temporal dynamics of CCR7+ DCs in anti-tumour immune responses remain unclear. Here, we use photoconvertible mice to precisely track DC migration. We report that CCR7+ DCs are the dominant DC population that migrate to the dLN, but a subset remains tumour-resident despite CCR7 expression. These tumour-retained CCR7+ DCs are phenotypically and transcriptionally distinct from their dLN counterparts and heterogeneous. Moreover, they progressively downregulate the expression of antigen presentation and pro-inflammatory transcripts with more prolonged tumour dwell-time. Tumour-residing CCR7+ DCs co-localise with PD-1+CD8+ T cells in human and murine solid tumours, and following anti-PD-L1 treatment, upregulate stimulatory molecules including OX40L, thereby augmenting anti-tumour cytolytic activity. Altogether, these data uncover previously unappreciated heterogeneity in CCR7+ DCs that may underpin a variable capacity to support intratumoural cytotoxic T cells. Recognition of tumour antigen induces dendritic cell activation and migration to the lymph node. Here, the authors use photoconvertible mice to demonstrate that some activated dendritic cells are retained in tumours and gradually lose function, but their ability to support local anti-tumour responses can be augmented by anti-PD-L1 blockade. [ABSTRACT FROM AUTHOR]

Published
2024
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5. CELEBRITY ESTATE PLANNING: Misfires of the Rich and Famous

Author

Goldsmith, Jessica Galligan, Kamen, Shaina S., Lazo, Christiana M., Posner, David J., and Steiner, Bruce D.

Subjects
Estate planning -- Case studies, Celebrities -- Planning, Company business planning, Law, Real estate industry
Abstract

Like many ordinary individuals, celebrities often have outdated or nonexistent estate plans. Even when a elebrity has done careful estate planning and has well-drafted documents, changes in family circumstances or [...]

Published
2018

11. Climate Change Justice

Author

Eric A. Posner, David Weisbach and Eric A. Posner, David Weisbach

Published
2010

26. Views of Our Readers

Author

Miller, Ben R., Burton, Thomas M., Gunderson, Gordon, Posner, David S., Petow, Patricia A., Hewitt, William R., Evans,, Daniel F., Schiller, Stephen A., Hightower, Toby, and Sutton,, John F.

Published
1977

29. Security interests in copyrights: the Ninth Circuit closes the loop and holds that article 9 governs perfection of unregistered copyrights.

Author

Posner, David M.

Subjects
Copyright -- Usage, Secured transactions -- Laws, regulations and rules, National Peregrine, Inc. v. Capital Federal Savings & Loan Ass'n (116 B.R. 194 (C.D. Cal. 1990)), Cybernetic Services v. Matsco, Inc. (252 F.3d 1039 (9th Cir. 2001)), Aerocon Engineering, Inc. v. Silicon Valley Bank (303 F.3d 1120 (9th Cir. 2002)), Government regulation, Patent/copyright issue, Uniform Commercial Code (U.C.C. 9)
Published
2003

33. Primary pulmonary hypertension associated with human immunodeficiency viral infection

Author

Coplan, Neil L., Shimony, Rony Y., Ioachim, Harry L., Wilentz, James R., Posner, David H., Lipschitz, Andrew, Ruden, Ronald A., Bruno, Michael S., Sherrid, Mark V., Gaetz, Harold, Englard, Arthur, Kukin, Marrick, and Packer, Milton

Subjects
Pulmonary hypertension -- Causes of, HIV infection -- Complications, AIDS (Disease) -- Complications, Pulmonary manifestations of general diseases -- Evaluation, Health, Health care industry
Abstract

Acquired immunodeficiency syndrome (AIDS) is associated with various cardiovascular disorders, such as impaired heart function; accumulation of fluid in the membrane surrounding the heart; cancer; and opportunistic infections. Four cases are described consisting of two patients with AIDS, and two patients with human immunodeficiency virus (HIV) infection. The patients developed high pressure (hypertension) in the pulmonary artery, the major blood vessel supplying the lungs, and were diagnosed as having primary pulmonary hypertension. This disorder is characterized by increased pulmonary arterial pressure resulting from structural abnormalities in the blood vessels due to some unknown cause. Two of the patients died, and the diagnosis of pulmonary hypertension was confirmed by autopsy. Primary pulmonary hypertension is associated with three pathologic characteristics: disease of the pulmonary arteries; recurrent blood clot formation in the pulmonary arteries; and obstruction of the pulmonary veins. Structural changes in the blood vessels include enlargement of the muscle layer, followed by cell overgrowth in the inner layer. There have been nine reports of HIV-infected patients with primary pulmonary hypertension. The mechanisms underlying the development of pulmonary hypertension associated with HIV infection are not clear, but may be related to a reaction of the lungs to HIV; the production of abnormal growth factors; or impaired function of the right heart ventricle due to opportunistic infection with Pneumocystis carinii. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1990

36. Weasel

Author

Posner, David

Published
1978

37. Dionysiou

Author

Posner, David

Published
1978

40. Fire-Alarm

Author

POSNER, DAVID

Published
1961

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