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7 results on '"Posnik, Bartlomiej"'

4. Acute Progression of Adult-Onset Atypical Hemolytic-Uremic Syndrome due to CFH Mutation: A Case Report

Author

Posnik, Bartlomiej, Sikorska, Dorota, Hoppe, Krzysztof, Schwermer, Krzysztof, Pawlaczyk, Krzysztof, and Oko, Andrzej

Subjects
Article Subject, hemic and lymphatic diseases, urologic and male genital diseases
Abstract

Atypical hemolytic-uremic syndrome (aHUS), unlike typical HUS, is not due to bacteria but rather to an idiopathic or genetic cause that promotes dysregulation of the alternative complement pathway. It leads to hemolytic anemia, thrombocytopenia, and renal impairment. Although aHUS secondary to a genetic mutation is relatively rare, when occurring due to a mutation in Factor H (CFH), it usually presents with younger onset and has a more severe course, which in the majority ends with end-stage renal failure. Paradoxically to most available data, our case features acute aHUS due to a CFH mutation with late onset (38-year-old) and rapid progression to end-stage renal disease. Due to current data indicating a high risk of graft failure in such patients, the diagnosis of aHUS secondary to a genetic cause has disqualified our patient from a living (family) donor renal transplantation and left her with no other option but to begin permanent renal replacement therapy.

Published
2013
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5. The Polymorphism of the ACE Gene Affects Left Ventricular Hypertrophy and Causes Disturbances in Left Ventricular Systolic/Diastolic Function in Patients with Autosomal Dominant Polycystic Kidney Disease

Author

Wanic-Kossowska, Maria, primary, Posnik, Bartlomiej, additional, Kobelski, Mikolaj, additional, Pawliczak, Elzbieta, additional, Pawlaczyk, Krzysztof, additional, Hoppe, Krzysztof, additional, Schwermer, Krzysztof, additional, and Sikorska, Dorota, additional

Published
2014
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7. Case Report: Syndrome of Inappropriate Antidiuretic Hormone and Tumor Lysis in Ovarian Cancer.

Author

Yedavalli, Nina Undevia, Zureikat, Neelima Rehil, and Posnik, Bartlomiej

Subjects
CANCER chemotherapy, HYPERURICEMIA, HYPONATREMIA, OVARIAN tumors, PACLITAXEL, OSMOLAR concentration, CARBOPLATIN, INAPPROPRIATE ADH syndrome, TUMOR lysis syndrome
Abstract

Paraneoplastic syndromes are rare disorders that are triggered by the presence of a malignancy in the body but are not directly caused by the cancer cells themselves. Syndrome of inappropriate antidiuretic hormone (SIADH) and tumor lysis syndrome (TLS) are well known paraneoplastic syndromes. Both of these syndromes are extremely rare in ovarian cancer. We present the case of a 64-year-old woman with a new diagnosis of ovarian cancer and associated SIADH. Two days after the first cycle of carboplatin and paclitaxel, the patient developed laboratory abnormalities consistent with TLS; however, the SIADH began to improve as seen by an increase in her serum sodium. The patient ultimately died 8 days after 1 cycle of chemotherapy secondary to multi-organ failure. This is a case report describing 2 rarely described paraneoplastic syndromes that not only occurred in the same patient, but also in a malignancy with which the syndromes are rarely associated--ovarian cancer. [ABSTRACT FROM AUTHOR]

Published
2016

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