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Your search keyword '"Post-operative pediatric cerebellar mutism syndrome"' showing total 3 results
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3 results on '"Post-operative pediatric cerebellar mutism syndrome"'

1. Cerebellar Mutism Syndrome in Children and Adults

Author

Mariën, Peter, Keulen, Stefanie, van Dun, Kim, De Smet, Hyo Jung, De Deyn, Peter P., Verhoeven, Jo, Paquier, Philippe, Schmahmann, Jeremy D., Section editor, Manto, Mario U., Section editor, Manto, Mario U., editor, Gruol, Donna L., editor, Schmahmann, Jeremy D., editor, Koibuchi, Noriyuki, editor, and Sillitoe, Roy V., editor

Published
2022
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2. A comparison study assessing neuropsychological outcome of patients with post-operative pediatric cerebellar mutism syndrome and matched controls after proton radiation therapy.

Author

Grieco, Julie A., Abrams, Annah N., Evans, Casey L., Yock, Torunn I., and Pulsifer, Margaret B.

Subjects
*PROTON therapy, *OCULAR hypotony, *VISUOMOTOR coordination, *RADIOTHERAPY, *FINE motor ability, *NEUROPSYCHOLOGICAL tests, *SYNDROMES
Abstract

Purpose: Post-operative pediatric cerebellar mutism syndrome (CMS), characterized by mutism, ataxia/hypotonia, and emotional lability, can result in long-term deficits following resection of posterior fossa (PF) tumors. This longitudinal study compared neuropsychological outcomes of pediatric patients with post-operative CMS to a matched control patient group without CMS. Methods: Fifty-eight PF tumor patients received post-surgical proton radiation therapy (PRT) and testing at baseline and at ≥ 1-year post-PRT over a 10-year period. Of these, 18 (31%) had post-operative CMS with baseline and follow-up neuropsychological test data. Those participants were matched to 18 controls by tumor location, age, gender, and handedness; no significant group differences were found at baseline for clinical/demographic variables. Total mean age at baseline was 7.26 years (SD = 4.42); mean follow-up interval was 3.26 years (SD = 2.24). Areas assessed: overall intelligence, expressive and receptive vocabulary, visuomotor integration, fine motor speed, inhibition, emotional control, depression, and anxiety. Results: Patients were 52% male; 86% medulloblastoma/14% ependymoma; 86% craniospinal irradiation/14% focal radiation; and 86% chemotherapy. No group differences were found between most mean baseline scores; expressive vocabulary and fine motor speed were significantly lower in the post-operative CMS group (p < 0.05). Mean change scores revealed no significant differences for the sample; scores were within the normal range except fine motor skills were impaired for both groups. Conclusions: Longitudinal neuropsychological outcomes for post-operative pediatric CMS patients did not differ significantly from matched controls without this condition. Patients were in the normal range in all areas except fine motor speed, which was impaired for both groups independent of CMS diagnosis. [ABSTRACT FROM AUTHOR]

Published
2020
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3. Cerebellar Mutism Syndrome in Children and Adults

Author

Mariën, Peter, Keulen, Stefanie, van Dun, Kim, De Smet, Hyo Jung, De Deyn, Peter P., Verhoeven, Jo, Paquier, Philippe, Mariën, Peter, Keulen, Stefanie, van Dun, Kim, De Smet, Hyo Jung, De Deyn, Peter P., Verhoeven, Jo, and Paquier, Philippe

Abstract

Cerebellar mutism can be considered the hallmark feature of the cerebellar mutism syndrome (CMS), previously also frequently termed the posterior fossa syndrome (PFS). The syndrome consists of specific linguistic, cognitive, behavioral, and affective symptoms following acute posterior fossa damage in children and adults. Although the symptoms have been exceptionally associated with non-tumoral etiologies, CMS usually develops after a brief period of relatively normal functioning in the immediate postoperative phase following posterior fossa tumor surgery. The incidence ofCMS in the pediatric population is estimated to range between 7% and 50%. Although similar symptoms have been occasionally reported in adults, CMS is typically viewed as a clinical condition affecting children. An international consensus as to the definition of CMS was recently reached. However, this accepted definition specifically addresses the pediatric variant of the syndrome associated with posterior fossa surgery (postoperative pediatric CMS, POPCMS). In this chapter, the more general term CMS (instead of POPCMS) will be used to denote similar symptoms also occurring in adults, and with non-tumoral etiologies. Although the semiology of CMS has extensively been described, the underlying pathophysiological mechanisms still remain largely unclear. This chapter presents a brief overview of the intriguing semiological combination of transient cerebellar mutism and cognitive, behavioral, and affective alterations following acute posterior fossa lesions. Furthermore, the most important pathophysiological hypotheses and the proposed therapeutic interventions will be briefly discussed.

Published
2021

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