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945 results on '"Postlethwait, John H."'

1. Multi-genome comparisons reveal gain-and-loss evolution of anti-Mullerian hormone receptor type 2 as a candidate master sex-determining gene in Percidae

Author

Kuhl, Heiner, Euclide, Peter T., Klopp, Christophe, Cabau, Cédric, Zahm, Margot, Lopez-Roques, Céline, Iampietro, Carole, Kuchly, Claire, Donnadieu, Cécile, Feron, Romain, Parrinello, Hugues, Poncet, Charles, Jaffrelo, Lydia, Confolent, Carole, Wen, Ming, Herpin, Amaury, Jouanno, Elodie, Bestin, Anastasia, Haffray, Pierrick, Morvezen, Romain, de Almeida, Taina Rocha, Lecocq, Thomas, Schaerlinger, Bérénice, Chardard, Dominique, Żarski, Daniel, Larson, Wesley A., Postlethwait, John H., Timirkhanov, Serik, Kloas, Werner, Wuertz, Sven, Stöck, Matthias, and Guiguen, Yann

Published
2024
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3. Promoting validation and cross-phylogenetic integration in model organism research

Author

Cheng, Keith C, Burdine, Rebecca D, Dickinson, Mary E, Ekker, Stephen C, Lin, Alex Y, Lloyd, KC Kent, Lutz, Cathleen M, MacRae, Calum A, Morrison, John H, O'Connor, David H, Postlethwait, John H, Rogers, Crystal D, Sanchez, Susan, Simpson, Julie H, Talbot, William S, Wallace, Douglas C, Weimer, Jill M, and Bellen, Hugo J

Subjects
Biological Sciences, Bioinformatics and Computational Biology, Underpinning research, 1.1 Normal biological development and functioning, Generic health relevance, Life Below Water, Animals, Biological Evolution, Humans, Phylogeny, Reproducibility of Results, Model organisms, Technology, Human diseases, Omics, Integration, Phenomics, Research resources, Validation, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences
Abstract

Model organism (MO) research provides a basic understanding of biology and disease due to the evolutionary conservation of the molecular and cellular language of life. MOs have been used to identify and understand the function of orthologous genes, proteins, cells and tissues involved in biological processes, to develop and evaluate techniques and methods, and to perform whole-organism-based chemical screens to test drug efficacy and toxicity. However, a growing richness of datasets and the rising power of computation raise an important question: How do we maximize the value of MOs? In-depth discussions in over 50 virtual presentations organized by the National Institutes of Health across more than 10 weeks yielded important suggestions for improving the rigor, validation, reproducibility and translatability of MO research. The effort clarified challenges and opportunities for developing and integrating tools and resources. Maintenance of critical existing infrastructure and the implementation of suggested improvements will play important roles in maintaining productivity and facilitating the validation of animal models of human biology and disease.

Published
2022

4. Transcriptomic and developmental effects of persistent organic pollutants in sentinel fishes collected near an arctic formerly used defense site

Author

Jordan-Ward, Renee, von Hippel, Frank A., Sancho Santos, Maria Eugenia, Wilson, Catherine A., Rodriguez Maldonado, Zyled, Dillon, Danielle, Titus, Tom, Gardell, Alison, Salamova, Amina, Postlethwait, John H., Contreras, Elise, Capozzi, Staci L., Panuwet, Parinya, Parrocha, Chelsea, Bremiller, Ruth, Guiguen, Yann, Gologergen, Jesse, Immingan, Tiffany, Miller, Pamela, Carpenter, David, and Buck, C. Loren

Published
2024
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6. Heterozygous loss-of-function variants significantly expand the phenotypes associated with loss of GDF11

Author

Ravenscroft, Thomas A, Phillips, Jennifer B, Fieg, Elizabeth, Bajikar, Sameer S, Peirce, Judy, Wegner, Jeremy, Luna, Alia A, Fox, Eric J, Yan, Yi-Lin, Rosenfeld, Jill A, Zirin, Jonathan, Kanca, Oguz, Benke, Paul J, Cameron, Eric S, Strehlow, Vincent, Platzer, Konrad, Jamra, Rami Abou, Klöckner, Chiara, Osmond, Matthew, Licata, Thomas, Rojas, Samantha, Dyment, David, Chong, Josephine SC, Lincoln, Sharyn, Stoler, Joan M, Postlethwait, John H, Wangler, Michael F, Yamamoto, Shinya, Krier, Joel, Westerfield, Monte, and Bellen, Hugo J

Subjects
Congenital Structural Anomalies, Genetics, Pediatric, 2.1 Biological and endogenous factors, Detection, screening and diagnosis, 4.1 Discovery and preclinical testing of markers and technologies, Aetiology, Animals, Bone Morphogenetic Proteins, Craniofacial Abnormalities, Growth Differentiation Factors, Humans, Mutation, Missense, Phenotype, Spine, Zebrafish, Undiagnosed Diseases Network, Clinical Sciences, Genetics & Heredity
Abstract

PurposeGrowth differentiation factor 11 (GDF11) is a key signaling protein required for proper development of many organ systems. Only one prior study has associated an inherited GDF11 variant with a dominant human disease in a family with variable craniofacial and vertebral abnormalities. Here, we expand the phenotypic spectrum associated with GDF11 variants and document the nature of the variants.MethodsWe present a cohort of six probands with de novo and inherited nonsense/frameshift (4/6 patients) and missense (2/6) variants in GDF11. We generated gdf11 mutant zebrafish to model loss of gdf11 phenotypes and used an overexpression screen in Drosophila to test variant functionality.ResultsPatients with variants in GDF11 presented with craniofacial (5/6), vertebral (5/6), neurological (6/6), visual (4/6), cardiac (3/6), auditory (3/6), and connective tissue abnormalities (3/6). gdf11 mutant zebrafish show craniofacial abnormalities and body segmentation defects that match some patient phenotypes. Expression of the patients' variants in the fly showed that one nonsense variant in GDF11 is a severe loss-of-function (LOF) allele whereas the missense variants in our cohort are partial LOF variants.ConclusionGDF11 is needed for human development, particularly neuronal development, and LOF GDF11 alleles can affect the development of numerous organs and tissues.

Published
2021

8. A Hormone That Lost Its Receptor: Anti-Müllerian Hormone (AMH) in Zebrafish Gonad Development and Sex Determination

Author

Yan, Yi-Lin, Batzel, Peter, Titus, Tom, Sydes, Jason, Desvignes, Thomas, BreMiller, Ruth, Draper, Bruce, and Postlethwait, John H

Subjects
Biological Sciences, Genetics, Contraception/Reproduction, 1.1 Normal biological development and functioning, Underpinning research, Reproductive health and childbirth, Animals, Anti-Mullerian Hormone, Female, Genitalia, Female, Gonads, Mullerian Ducts, Ovarian Follicle, Ovary, RNA-Seq, Receptors, Peptide, Receptors, Transforming Growth Factor beta, Sex Determination Processes, Zebrafish, germ cells, PGC, male fertility, female fertility, gonad development, Genetics of Sex, Developmental Biology, Biochemistry and cell biology
Abstract

Fetal mammalian testes secrete Anti-Müllerian hormone (Amh), which inhibits female reproductive tract (Müllerian duct) development. Amh also derives from mature mammalian ovarian follicles, which marks oocyte reserve and characterizes polycystic ovarian syndrome. Zebrafish (Danio rerio) lacks Müllerian ducts and the Amh receptor gene amhr2 but, curiously, retains amh To discover the roles of Amh in the absence of Müllerian ducts and the ancestral receptor gene, we made amh null alleles in zebrafish. Results showed that normal amh prevents female-biased sex ratios. Adult male amh mutants had enormous testes, half of which contained immature oocytes, demonstrating that Amh regulates male germ cell accumulation and inhibits oocyte development or survival. Mutant males formed sperm ducts and some produced a few offspring. Young female mutants laid a few fertile eggs, so they also had functional sex ducts. Older amh mutants accumulated nonvitellogenic follicles in exceedingly large but sterile ovaries, showing that Amh helps control ovarian follicle maturation and proliferation. RNA-sequencing data partitioned juveniles at 21 days postfertilization (dpf) into two groups that each contained mutant and wild-type fish. Group21-1 upregulated ovary genes compared to Group21-2, which were likely developing as males. By 35 dpf, transcriptomes distinguished males from females and, within each sex, mutants from wild types. In adult mutants, ovaries greatly underexpressed granulosa and theca genes, and testes underexpressed Leydig cell genes. These results show that ancestral Amh functions included development of the gonadal soma in ovaries and testes and regulation of gamete proliferation and maturation. A major gap in our understanding is the identity of the gene encoding a zebrafish Amh receptor; we show here that the loss of amhr2 is associated with the breakpoint of a chromosome rearrangement shared among cyprinid fishes.

Published
2019

9. Female Sex Development and Reproductive Duct Formation Depend on Wnt4a in Zebrafish.

Author

Kossack, Michelle E, High, Samantha K, Hopton, Rachel E, Yan, Yi-Lin, Postlethwait, John H, and Draper, Bruce W

Subjects
Mullerian Ducts, Animals, Zebrafish, Zebrafish Proteins, Sex Differentiation, Female, Male, Fibroblast Growth Factor 9, Wnt4 Protein, Genetics of Sex, reproductive duct, sex determination, sex differentiation, wnt4a, zebrafish, Genetics, Developmental Biology
Abstract

In laboratory strains of zebrafish, sex determination occurs in the absence of a typical sex chromosome and it is not known what regulates the proportion of animals that develop as males or females. Many sex determination and gonad differentiation genes that act downstream of a sex chromosome are well conserved among vertebrates, but studies that test their contribution to this process have mostly been limited to mammalian models. In mammals, WNT4 is a signaling ligand that is essential for ovary and Müllerian duct development, where it antagonizes the male-promoting FGF9 signal. Wnt4 is well conserved across all vertebrates, but it is not known if Wnt4 plays a role in sex determination and/or the differentiation of sex organs in nonmammalian vertebrates. This question is especially interesting in teleosts, such as zebrafish, because they lack an Fgf9 ortholog. Here we show that wnt4a is the ortholog of mammalian Wnt4, and that wnt4b was present in the last common ancestor of humans and zebrafish, but was lost in mammals. We show that wnt4a loss-of-function mutants develop predominantly as males and conclude that wnt4a activity promotes female sex determination and/or differentiation in zebrafish. Additionally, both male and female wnt4a mutants are sterile due to defects in reproductive duct development. Together these results strongly argue that Wnt4a is a conserved regulator of female sex determination and reproductive duct development in mammalian and nonmammalian vertebrates.

Published
2019

12. Effect of Genetic Diagnosis on Patients with Previously Undiagnosed Disease

Author

Splinter, Kimberly, Adams, David R, Bacino, Carlos A, Bellen, Hugo J, Bernstein, Jonathan A, Cheatle-Jarvela, Alys M, Eng, Christine M, Esteves, Cecilia, Gahl, William A, Hamid, Rizwan, Jacob, Howard J, Kikani, Bijal, Koeller, David M, Kohane, Isaac S, Lee, Brendan H, Loscalzo, Joseph, Luo, Xi, McCray, Alexa T, Metz, Thomas O, Mulvihill, John J, Nelson, Stanley F, Palmer, Christina GS, Phillips, John A, Pick, Leslie, Postlethwait, John H, Reuter, Chloe, Shashi, Vandana, Sweetser, David A, Tifft, Cynthia J, Walley, Nicole M, Wangler, Michael F, Westerfield, Monte, Wheeler, Matthew T, Wise, Anastasia L, Worthey, Elizabeth A, Yamamoto, Shinya, and Ashley, Euan A

Subjects
Genetics, Clinical Research, Digestive Diseases, Health Services, Human Genome, Rare Diseases, Good Health and Well Being, Adult, Animals, Child, Diagnosis, Differential, Drosophila, Exome, Female, Genetic Testing, Health Care Costs, Humans, Male, Models, Animal, National Institutes of Health (U.S.), Sequence Analysis, DNA, Syndrome, United States, Undiagnosed Diseases Network, Medical and Health Sciences, General & Internal Medicine
Abstract

BackgroundMany patients remain without a diagnosis despite extensive medical evaluation. The Undiagnosed Diseases Network (UDN) was established to apply a multidisciplinary model in the evaluation of the most challenging cases and to identify the biologic characteristics of newly discovered diseases. The UDN, which is funded by the National Institutes of Health, was formed in 2014 as a network of seven clinical sites, two sequencing cores, and a coordinating center. Later, a central biorepository, a metabolomics core, and a model organisms screening center were added.MethodsWe evaluated patients who were referred to the UDN over a period of 20 months. The patients were required to have an undiagnosed condition despite thorough evaluation by a health care provider. We determined the rate of diagnosis among patients who subsequently had a complete evaluation, and we observed the effect of diagnosis on medical care.ResultsA total of 1519 patients (53% female) were referred to the UDN, of whom 601 (40%) were accepted for evaluation. Of the accepted patients, 192 (32%) had previously undergone exome sequencing. Symptoms were neurologic in 40% of the applicants, musculoskeletal in 10%, immunologic in 7%, gastrointestinal in 7%, and rheumatologic in 6%. Of the 382 patients who had a complete evaluation, 132 received a diagnosis, yielding a rate of diagnosis of 35%. A total of 15 diagnoses (11%) were made by clinical review alone, and 98 (74%) were made by exome or genome sequencing. Of the diagnoses, 21% led to recommendations regarding changes in therapy, 37% led to changes in diagnostic testing, and 36% led to variant-specific genetic counseling. We defined 31 new syndromes.ConclusionsThe UDN established a diagnosis in 132 of the 382 patients who had a complete evaluation, yielding a rate of diagnosis of 35%. (Funded by the National Institutes of Health Common Fund.).

Published
2018

13. Partial Loss of USP9X Function Leads to a Male Neurodevelopmental and Behavioral Disorder Converging on Transforming Growth Factor β Signaling

Author

Pena, Loren, Shashi, Vandana, Schoch, Kelly, Sullivan, Jennifer A., Acosta, Maria T., Adams, David R., Aday, Aaron, Alejandro, Mercedes E., Allard, Patrick, Ashley, Euan A., Azamian, Mahshid S., Bacino, Carlos A., Bademci, Guney, Baker, Eva, Balasubramanyam, Ashok, Baldridge, Dustin, Barbouth, Deborah, Batzli, Gabriel F., Beggs, Alan H., Bellen, Hugo J., Bernstein, Jonathan A., Berry, Gerard T., Bican, Anna, Bick, David P., Birch, Camille L., Bivona, Stephanie, Bonnenmann, Carsten, Bonner, Devon, Boone, Braden E., Bostwick, Bret L., Briere, Lauren C., Brokamp, Elly, Brown, Donna M., Brush, Matthew, Burke, Elizabeth A., Burrage, Lindsay C., Butte, Manish J., Carrasquillo, Olveen, Peter Chang, Ta Chen, Chao, Hsiao-Tuan, Clark, Gary D., Coakley, Terra R., Cobban, Laurel A., Cogan, Joy D., Cole, F. Sessions, Colley, Heather A., Cooper, Cynthia M., Cope, Heidi, Craigen, William J., D'Souza, Precilla, Dasari, Surendra, Davids, Mariska, Davidson, Jean M., Dayal, Jyoti G., Dell'Angelica, Esteban C., Dhar, Shweta U., Dorrani, Naghmeh, Dorset, Daniel C., Douine, Emilie D., Draper, David D., Dries, Annika M., Duncan, Laura, Eckstein, David J., Emrick, Lisa T., Eng, Christine M., Enns, Gregory M., Esteves, Cecilia, Estwick, Tyra, Fernandez, Liliana, Ferreira, Carlos, Fieg, Elizabeth L., Fisher, Paul G., Fogel, Brent L., Forghani, Irman, Friedman, Noah D., Gahl, William A., Godfrey, Rena A., Goldman, Alica M., Goldstein, David B., Gourdine, Jean-Philippe F., Grajewski, Alana, Groden, Catherine A., Gropman, Andrea L., Haendel, Melissa, Hamid, Rizwan, Hanchard, Neil A., High, Frances, Holm, Ingrid A., Hom, Jason, Huang, Alden, Huang, Yong, Isasi, Rosario, Jamal, Fariha, Jiang, Yong-hui, Johnston, Jean M., Jones, Angela L., Karaviti, Lefkothea, Kelley, Emily G., Koeller, David M., Kohane, Isaac S., Kohler, Jennefer N., Krakow, Deborah, Krasnewich, Donna M., Korrick, Susan, Koziura, Mary, Krier, Joel B., Kyle, Jennifer E., Lalani, Seema R., Lam, Byron, Lanpher, Brendan C., Lanza, Ian R., Lau, C. Christopher, Lazar, Jozef, LeBlanc, Kimberly, Lee, Brendan H., Lee, Hane, Levitt, Roy, Levy, Shawn E., Lewis, Richard A., Lincoln, Sharyn A., Liu, Pengfei, Liu, Xue Zhong, Loo, Sandra K., Loscalzo, Joseph, Maas, Richard L., Macnamara, Ellen F., MacRae, Calum A., Maduro, Valerie V., Majcherska, Marta M., Malicdan, May Christine V., Mamounas, Laura A., Manolio, Teri A., Markello, Thomas C., Marom, Ronit, Martin, Martin G., Martínez-Agosto, Julian A., Marwaha, Shruti, May, Thomas, McCauley, Jacob, McConkie-Rosell, Allyn, McCormack, Colleen E., McCray, Alexa T., Merker, Jason D., Metz, Thomas O., Might, Matthew, Morava-Kozicz, Eva, Moretti, Paolo M., Morimoto, Marie, Mulvihill, John J., Murdock, David R., Nath, Avi, Nelson, Stan F., Newberry, J. Scott, Newman, John H., Nicholas, Sarah K., Novacic, Donna, Oglesbee, Devin, Orengo, James P., Pak, Stephen, Pallais, J. Carl, Palmer, Christina GS., Papp, Jeanette C., Parker, Neil H., Phillips, John A., III, Posey, Jennifer E., Postlethwait, John H., Potocki, Lorraine, Pusey, Barbara N., Renteri, Genecee, Reuter, Chloe M., Rives, Lynette, Robertson, Amy K., Rodan, Lance H., Rosenfeld, Jill A., Rowley, Robb K., Sacco, Ralph, Sampson, Jacinda B., Samson, Susan L., Saporta, Mario, Schaechter, Judy, Schedl, Timothy, Scott, Daryl A., Shakachite, Lisa, Sharma, Prashant, Shields, Kathleen, Shin, Jimann, Signer, Rebecca, Sillari, Catherine H., Silverman, Edwin K., Sinsheimer, Janet S., Smith, Kevin S., Solnica-Krezel, Lilianna, Spillmann, Rebecca C., Stoler, Joan M., Stong, Nicholas, Sweetser, David A., Tamburro, Cecelia P., Tan, Queenie K.-G., Tekin, Mustafa, Telischi, Fred, Thorson, Willa, Tifft, Cynthia J., Toro, Camilo, Tran, Alyssa A., Urv, Tiina K., Vogel, Tiphanie P., Waggott, Daryl M., Wahl, Colleen E., Walley, Nicole M., Walsh, Chris A., Walker, Melissa, Wambach, Jennifer, Wan, Jijun, Wang, Lee-kai, Wangler, Michael F., Ward, Patricia A., Waters, Katrina M., Webb-Robertson, Bobbie-Jo M., Wegner, Daniel, Westerfield, Monte, Wheeler, Matthew T., Wise, Anastasia L., Wolfe, Lynne A., Woods, Jeremy D., Worthey, Elizabeth A., Yamamoto, Shinya, Yang, John, Yoon, Amanda J., Yu, Guoyun, Zastrow, Diane B., Zhao, Chunli, Zuchner, Stephan, Gahl, William, Johnson, Brett V., Kumar, Raman, Oishi, Sabrina, Alexander, Suzy, Kasherman, Maria, Vega, Michelle Sanchez, Ivancevic, Atma, Gardner, Alison, Domingo, Deepti, Corbett, Mark, Parnell, Euan, Yoon, Sehyoun, Oh, Tracey, Lines, Matthew, Lefroy, Henrietta, Kini, Usha, Van Allen, Margot, Grønborg, Sabine, Mercier, Sandra, Küry, Sébastien, Bézieau, Stéphane, Pasquier, Laurent, Raynaud, Martine, Afenjar, Alexandra, Billette de Villemeur, Thierry, Keren, Boris, Désir, Julie, Van Maldergem, Lionel, Marangoni, Martina, Dikow, Nicola, Koolen, David A., VanHasselt, Peter M., Weiss, Marjan, Zwijnenburg, Petra, Sa, Joaquim, Reis, Claudia Falcao, López-Otín, Carlos, Santiago-Fernández, Olaya, Fernández-Jaén, Alberto, Rauch, Anita, Steindl, Katharina, Joset, Pascal, Goldstein, Amy, Madan-Khetarpal, Suneeta, Infante, Elena, Zackai, Elaine, Mcdougall, Carey, Narayanan, Vinodh, Ramsey, Keri, Mercimek-Andrews, Saadet, Pinto e Vairo, Filippo, Pichurin, Pavel N., Ewing, Sarah A., Barnett, Sarah S., Klee, Eric W., Perry, M. Scott, Koenig, Mary Kay, Keegan, Catherine E., Schuette, Jane L., Asher, Stephanie, Perilla-Young, Yezmin, Smith, Laurie D., Bhoj, Elizabeth, Kaplan, Paige, Li, Dong, Oegema, Renske, van Binsbergen, Ellen, van der Zwaag, Bert, Smeland, Marie Falkenberg, Cutcutache, Ioana, Page, Matthew, Armstrong, Martin, Lin, Angela E., Steeves, Marcie A., Hollander, Nicolette den, Hoffer, Mariëtte J.V., Reijnders, Margot R.F., Demirdas, Serwet, Koboldt, Daniel C., Bartholomew, Dennis, Mosher, Theresa Mihalic, Hickey, Scott E., Shieh, Christine, Sanchez-Lara, Pedro A., Graham, John M., Jr., Tezcan, Kamer, Schaefer, G.B., Danylchuk, Noelle R., Asamoah, Alexander, Jackson, Kelly E., Yachelevich, Naomi, Au, Margaret, Pérez-Jurado, Luis A., Kleefstra, Tjitske, Penzes, Peter, Wood, Stephen A., Burne, Thomas, Pierson, Tyler Mark, Piper, Michael, Gécz, Jozef, and Jolly, Lachlan A.

Published
2020
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15. The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons

Author

Braasch, Ingo, Gehrke, Andrew R, Smith, Jeramiah J, Kawasaki, Kazuhiko, Manousaki, Tereza, Pasquier, Jeremy, Amores, Angel, Desvignes, Thomas, Batzel, Peter, Catchen, Julian, Berlin, Aaron M, Campbell, Michael S, Barrell, Daniel, Martin, Kyle J, Mulley, John F, Ravi, Vydianathan, Lee, Alison P, Nakamura, Tetsuya, Chalopin, Domitille, Fan, Shaohua, Wcisel, Dustin, Cañestro, Cristian, Sydes, Jason, Beaudry, Felix EG, Sun, Yi, Hertel, Jana, Beam, Michael J, Fasold, Mario, Ishiyama, Mikio, Johnson, Jeremy, Kehr, Steffi, Lara, Marcia, Letaw, John H, Litman, Gary W, Litman, Ronda T, Mikami, Masato, Ota, Tatsuya, Saha, Nil Ratan, Williams, Louise, Stadler, Peter F, Wang, Han, Taylor, John S, Fontenot, Quenton, Ferrara, Allyse, Searle, Stephen MJ, Aken, Bronwen, Yandell, Mark, Schneider, Igor, Yoder, Jeffrey A, Volff, Jean-Nicolas, Meyer, Axel, Amemiya, Chris T, Venkatesh, Byrappa, Holland, Peter WH, Guiguen, Yann, Bobe, Julien, Shubin, Neil H, Di Palma, Federica, Alföldi, Jessica, Lindblad-Toh, Kerstin, and Postlethwait, John H

Subjects
Biological Sciences, Bioinformatics and Computational Biology, Genetics, Human Genome, Animals, Evolution, Molecular, Female, Fishes, Genome, Humans, Karyotype, Models, Genetic, Organ Specificity, Sequence Analysis, DNA, Transcriptome, Medical and Health Sciences, Developmental Biology, Agricultural biotechnology, Bioinformatics and computational biology
Abstract

To connect human biology to fish biomedical models, we sequenced the genome of spotted gar (Lepisosteus oculatus), whose lineage diverged from teleosts before teleost genome duplication (TGD). The slowly evolving gar genome has conserved in content and size many entire chromosomes from bony vertebrate ancestors. Gar bridges teleosts to tetrapods by illuminating the evolution of immunity, mineralization and development (mediated, for example, by Hox, ParaHox and microRNA genes). Numerous conserved noncoding elements (CNEs; often cis regulatory) undetectable in direct human-teleost comparisons become apparent using gar: functional studies uncovered conserved roles for such cryptic CNEs, facilitating annotation of sequences identified in human genome-wide association studies. Transcriptomic analyses showed that the sums of expression domains and expression levels for duplicated teleost genes often approximate the patterns and levels of expression for gar genes, consistent with subfunctionalization. The gar genome provides a resource for understanding evolution after genome duplication, the origin of vertebrate genomes and the function of human regulatory sequences.

Published
2016

20. Contributors

Author

Ansari, Rida, primary, Appelbaum, Lior, additional, Bartel, W. Philip, additional, Bonan, Carla Denise, additional, Brennan, Caroline H., additional, Burton, Edward A., additional, Carvan III, Michael J., additional, Clark, Karl J., additional, Da Silva, Rosane Souza, additional, Demin, Konstantin A., additional, De Santis, Flavia, additional, Di Donato, Vincenzo, additional, Dreosti, Elena, additional, Ekker, Marc, additional, Facciol, Amanda, additional, Flik, Gert, additional, Gerlai, Robert T., additional, Gorissen, Marnix, additional, Grieco, Fabrizio, additional, Guo, Su, additional, Heeren, Amanda A., additional, Higgs, Dennis M., additional, Hoffman, Ellen J., additional, Howe, Kerstin, additional, Hua, Khang, additional, Jenett, Arnim, additional, Kalueff, Allan V., additional, Kalyviotis, Konstantinos, additional, Kenney, Justin W., additional, Lakstygal, Anton M., additional, Lee, Han B., additional, Marquez-Legorreta, Emmanuel, additional, Miller, Noam, additional, Modhurima, Rodsy, additional, Neuhauss, Stephan C.F., additional, Noldus, Lucas P.J.J., additional, Norton, William HJ., additional, Pantazis, Periklis, additional, Parichy, David M., additional, Piber, Marielle, additional, Postlethwait, John H., additional, Pritchett, David, additional, Qin, Hanyu, additional, Rihel, Jason, additional, Schlegel, Domino K., additional, Scott, Ethan K., additional, Stankiewicz, Alexander, additional, Stednitz, S.J., additional, Tegelenbosch, Ruud A.J., additional, Terriente, Javier, additional, Tran, Steven, additional, Tsang, Benjamin, additional, Tsuda, Sachiko, additional, van den Bos, Ruud, additional, Van Laar, Victor S., additional, Vianna, Monica Ryff Moreira Roca, additional, Washbourne, P., additional, Winberg, Svante, additional, Xu, Jiale, additional, Zada, David, additional, and Zhdanova, Irina V., additional

Published
2021
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21. A maternal-to-zygotic-transition gene block on the zebrafish sex chromosome.

Author

Wilson, Catherine A and Postlethwait, John H

Subjects
*GENETIC sex determination, *SEX chromosomes, *GONADS, *SEX determination, *REGULATOR genes, *GENE expression, *BRACHYDANIO
Abstract

Wild zebrafish (Danio rerio) have a ZZ/ZW chromosomal sex-determination system with the major sex locus on the right arm of chromosome-4 (Chr4R) near the largest heterochromatic block in the genome, suggesting that Chr4R transcriptomics might differ from the rest of the genome. To test this hypothesis, we conducted an RNA-seq analysis of adult ZW ovaries and ZZ testes in the Nadia strain and identified 4 regions of Chr4 with different gene expression profiles. Unique in the genome, protein-coding genes in a 41.7 Mb section (Region-2) were expressed in testis but silent in ovary. The AB lab strain, which lacks sex chromosomes, verified this result, showing that testis-biased gene expression in Region-2 depends on gonad biology, not on sex-determining mechanism. RNA-seq analyses in female and male brains and livers validated reduced transcripts from Region-2 in somatic cells, but without sex specificity. Region-2 corresponds to the heterochromatic portion of Chr4R and its content of genes and repetitive elements distinguishes it from the rest of the genome. Region-2 lacks protein-coding genes with human orthologs; has zinc finger genes expressed early in zygotic genome activation; has maternal 5S rRNA genes, maternal spliceosome genes, a concentration of tRNA genes, and a distinct set of repetitive elements. The colocalization of (1) genes silenced in ovaries but not in testes that are (2) expressed in embryos briefly at the onset of zygotic genome activation; (3) maternal-specific genes for translation machinery; (4) maternal-specific spliceosome components; and (5) adjacent genes encoding miR-430, which mediates maternal transcript degradation, suggest that this is a maternal-to-zygotic-transition gene regulatory block. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Direct male development in chromosomally ZZ zebrafish.

Author

Wilson, Catherine A., Batzel, Peter, and Postlethwait, John H.

Subjects
GENETIC sex determination, SEX determination, BRACHYDANIO, GERM cells, GRANULOSA cells
Abstract

The genetics of sex determination varies across taxa, sometimes even within a species. Major domesticated strains of zebrafish (Danio rerio), including AB and TU, lack a strong genetic sex determining locus, but strains more recently derived from nature, like Nadia (NA), possess a ZZ male/ZW female chromosomal sexdetermination system. AB fish pass through a juvenile ovary stage, forming oocytes that survive in fish that become females but die in fish that become males. To understand mechanisms of gonad development in NA zebrafish, we studied histology and single cell transcriptomics in developing ZZ and ZW fish. ZW fish developed oocytes by 22 days post-fertilization (dpf) but ZZ fish directly formed testes, avoiding a juvenile ovary phase. Gonads of some ZW andWW fish, however, developed oocytes that died as the gonad became a testis, mimicking AB fish, suggesting that the gynogenetically derived AB strain is chromosomally WW. Single-cell RNA-seq of 19dpf gonads showed similar cell types in ZZ and ZW fish, including germ cells, precursors of gonadal support cells, steroidogenic cells, interstitial/stromal cells, and immune cells, consistent with a bipotential juvenile gonad. In contrast, scRNA-seq of 30dpf gonads revealed that cells in ZZ gonads had transcriptomes characteristic of testicular Sertoli, Leydig, and germ cells while ZW gonads had granulosa cells, theca cells, and developing oocytes. Hematopoietic and vascular cells were similar in both sex genotypes. These results show that juvenile NA zebrafish initially develop a bipotential gonad; that a factor on the NAWchromosome, or fewer than two Z chromosomes, is essential to initiate oocyte development; and without theWfactor, or with two Z doses, NA gonads develop directly into testes without passing through the juvenile ovary stage. Sex determination in AB and TU strains mimics NA ZW and WW zebrafish, suggesting loss of the Z chromosome during domestication. Genetic analysis of the NA strain will facilitate our understanding of the evolution of sex determination mechanisms. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Multi-genome comparisons reveal gain-and-loss evolution of the anti-Mullerian hormone receptor type 2 gene, an old master sex determining gene, in Percidae

Author

Kuhl, Heiner, primary, Euclide, Peter, additional, Klopp, Christophe, additional, Cabau, Cédric, additional, Zahm, Margot, additional, Roques, Celine, additional, Iampietro, Carole, additional, Kuchly, Claire, additional, Donnadieu, Cécile, additional, Feron, Romain, additional, Parrinello, Hugues, additional, Poncet, Charles, additional, Jaffrelo, Lydia, additional, Confolent, Carole, additional, Wen, Ming, additional, Herpin, Amaury, additional, Jouanno, Elodie, additional, Bestin, Anastasia, additional, Haffray, Pierrick, additional, Morvezen, Romain, additional, Almeida, Taina Rocha de, additional, Lecocq, Thomas, additional, Schaerlinger, Berenice, additional, Chardard, Dominique, additional, ŻARSKI, Daniel, additional, Larson, Wes, additional, Postlethwait, John H, additional, Timirkhanov, Serik, additional, Kloas, Werner, additional, Wuertz, Swen, additional, Stöck, Matthias, additional, and Guiguen, Yann, additional

Published
2023
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25. Differential gene expression and developmental pathologies associated with persistent organic pollutants in sentinel fish in Troutman Lake, Sivuqaq, Alaska

Author

Jordan-Ward, Renee, primary, von Hippel, Frank A., additional, Wilson, Catherine A., additional, Rodriguez Maldonado, Zyled, additional, Dillon, Danielle, additional, Contreras, Elise, additional, Gardell, Alison, additional, Minicozzi, Michael R., additional, Titus, Tom, additional, Ungwiluk, Bobby, additional, Miller, Pamela, additional, Carpenter, David, additional, Postlethwait, John H., additional, Byrne, Samuel, additional, and Buck, C. Loren, additional

Published
2023
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28. Contributors

Author

Aliucci, John, primary, Aman, Andrew J., additional, Barresi, Michael J.F., additional, Barton, Carrie L., additional, Baumann, Diana P., additional, Braasch, Ingo, additional, Brockerhoff, Susan E., additional, Burgess, Shawn M., additional, Cartner, Samuel C., additional, Castranova, Daniel, additional, Chow, Dawnis M., additional, Cleghorn, Whitney M., additional, Cockington, Jason, additional, Coffin, Allison B., additional, Collymore, Chereen, additional, Cox, James D., additional, Crim, Marcus J., additional, Currie, Peter, additional, D'Abramo, Louis R., additional, Davidson, Alan J., additional, Diep, Cuong Q., additional, Draper, Bruce W., additional, Durboraw, Earle, additional, Eisen, Judith S., additional, Farmer, Susan C., additional, Fetcho, Joseph R., additional, Fischer, Kay, additional, Fowler, L. Adele, additional, Galanternik, Marina Venero, additional, Ganz, Julia, additional, Gorelick, Daniel A., additional, Guillemin, Karen J., additional, Habenicht, Lauren M., additional, Hammer, Hugh S., additional, Hudson, Alexandria M., additional, Jonz, Michael G., additional, Kaslin, Jan, additional, Kent, Michael L., additional, Kimelman, David, additional, Kwon, Ronald Y., additional, Lains, David, additional, Lawrence, Christian, additional, Ledin, Johan, additional, Lee, Carole J., additional, Li, Jianlong, additional, Lieggi, Christine, additional, Löhr, Christiana, additional, McArthur, Kimberly L., additional, McCluskey, Braedan M., additional, Mikeasky, Noriko, additional, Mulrooney, Donna, additional, Murray, Katrina N., additional, Nichols, James T., additional, Pandolfo, Lauren, additional, Parichy, David M., additional, Pathak, Narendra H., additional, Paull, Gregory C., additional, Peterson, Randall T., additional, Phillips, Jennifer B., additional, Postlethwait, John H., additional, Prochaska, Morgan, additional, Raible, David W., additional, Rissone, Alberto, additional, Sanders, Erik, additional, Sanders, George E., additional, Sanders, Justin L., additional, Siegfried, Kellee R., additional, Smith, Natalie L., additional, Spagnoli, Sean T., additional, Stratman, Amber N., additional, Thomas, Eric D., additional, Traver, David, additional, Tulenko, Frank J., additional, Tyler, Charles R., additional, Wallace, Kenneth N., additional, Wang, Chongmin, additional, Watson, Claire J., additional, Watts, Amanda, additional, Watts, Stephen A., additional, Weinstein, Brant M., additional, Westerfield, Monte, additional, Whipps, Christopher M., additional, Wiles, Travis J., additional, Williams, Michael B., additional, Yoder, Jeffrey A., additional, Zhang, Tejia, additional, and Zynda, Jeffrey R., additional

Published
2020
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30. EML1 (CNG-Modulin) Controls Light Sensitivity in Darkness and under Continuous Illumination in Zebrafish Retinal Cone Photoreceptors

Author

Korenbrot, Juan I, Mehta, Milap, Tserentsoodol, Nomingerel, Postlethwait, John H, and Rebrik, Tatiana I

Subjects
Biomedical and Clinical Sciences, Neurosciences, Animals, Animals, Genetically Modified, Darkness, Electroretinography, Light, Lighting, Microtubule-Associated Proteins, Photic Stimulation, Photophobia, Retinal Cone Photoreceptor Cells, Zebrafish, Medical and Health Sciences, Psychology and Cognitive Sciences, Neurology & Neurosurgery
Abstract

The ligand sensitivity of cGMP-gated (CNG) ion channels in cone photoreceptors is modulated by CNG-modulin, a Ca(2+)-binding protein. We investigated the functional role of CNG-modulin in phototransduction in vivo in morpholino-mediated gene knockdown zebrafish. Through comparative genomic analysis, we identified the orthologue gene of CNG-modulin in zebrafish, eml1, an ancient gene present in the genome of all vertebrates sequenced to date. We compare the photoresponses of wild-type cones with those of cones that do not express the EML1 protein. In the absence of EML1, dark-adapted cones are ∼5.3-fold more light sensitive than wild-type cones. Previous qualitative studies in several nonmammalian species have shown that immediately after the onset of continuous illumination, cones are less light sensitive than in darkness, but sensitivity then recovers over the following 15-20 s. We characterize light sensitivity recovery in continuously illuminated wild-type zebrafish cones and demonstrate that sensitivity recovery does not occur in the absence of EML1.

Published
2013

31. Antarctic blackfin icefish genome reveals adaptations to extreme environments

Author

Kim, Bo-Mi, Amores, Angel, Kang, Seunghyun, Ahn, Do-Hwan, Kim, Jin-Hyoung, Kim, Il-Chan, Lee, Jun Hyuck, Lee, Sung Gu, Lee, Hyoungseok, Lee, Jungeun, Kim, Han-Woo, Desvignes, Thomas, Batzel, Peter, Sydes, Jason, Titus, Tom, Wilson, Catherine A., Catchen, Julian M., Warren, Wesley C., Schartl, Manfred, Detrich, III, H. William, Postlethwait, John H., and Park, Hyun

Published
2019
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34. Genomics of cold adaptations in the Antarctic notothenioid fish radiation

Author

Bista, Iliana, primary, Wood, Jonathan M. D., additional, Desvignes, Thomas, additional, McCarthy, Shane A., additional, Matschiner, Michael, additional, Ning, Zemin, additional, Tracey, Alan, additional, Torrance, James, additional, Sims, Ying, additional, Chow, William, additional, Smith, Michelle, additional, Oliver, Karen, additional, Haggerty, Leanne, additional, Salzburger, Walter, additional, Postlethwait, John H., additional, Howe, Kerstin, additional, Clark, Melody S., additional, William Detrich, H., additional, Christina Cheng, C.-H., additional, Miska, Eric A., additional, and Durbin, Richard, additional

Published
2023
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36. Differential allelic representation (DAR) identifies candidate eQTLs and improves transcriptome analysis.

Author

Baer, Lachlan, Barthelson, Karissa, Postlethwait, John H., Adelson, David L., Pederson, Stephen M., and Lardelli, Michael

Subjects
LOCUS (Genetics), GENE expression, BIOLOGICAL systems, HOMOZYGOSITY, CHROMOSOMES, ORYZIAS latipes
Abstract

In comparisons between mutant and wild-type genotypes, transcriptome analysis can reveal the direct impacts of a mutation, together with the homeostatic responses of the biological system. Recent studies have highlighted that, when the effects of homozygosity for recessive mutations are studied in non-isogenic backgrounds, genes located proximal to the mutation on the same chromosome often appear over-represented among those genes identified as differentially expressed (DE). One hypothesis suggests that DE genes chromosomally linked to a mutation may not reflect functional responses to the mutation but, instead, result from an unequal distribution of expression quantitative trait loci (eQTLs) between sample groups of mutant or wild-type genotypes. This is problematic because eQTL expression differences are difficult to distinguish from genes that are DE due to functional responses to a mutation. Here we show that chromosomally co-located differentially expressed genes (CC-DEGs) are also observed in analyses of dominant mutations in heterozygotes. We define a method and a metric to quantify, in RNA-sequencing data, localised differential allelic representation (DAR) between those sample groups subjected to differential expression analysis. We show how the DAR metric can predict regions prone to eQTL-driven differential expression, and how it can improve functional enrichment analyses through gene exclusion or weighting-based approaches. Advantageously, this improved ability to identify probable eQTLs also reveals examples of CC-DEGs that are likely to be functionally related to a mutant phenotype. This supports a long-standing prediction that selection for advantageous linkage disequilibrium influences chromosome evolution. By comparing the genomes of zebrafish (Danio rerio) and medaka (Oryzias latipes), a teleost with a conserved ancestral karyotype, we find possible examples of chromosomal aggregation of CC-DEGs during evolution of the zebrafish lineage. Our method for DAR analysis requires only RNA-sequencing data, facilitating its application across new and existing datasets. Author summary: Many human-relevant diseases result from genetic mutations that disrupt cellular functions. We can model these mutations in other organisms (e.g. mouse, zebrafish) and employ gene expression analysis (transcriptomics) to determine how mutations directly affect cells and how cells adjust expression of their genes to compensate for these mutations. In our transcriptome analyses of dominant disease-causative mutations in zebrafish, we identified an interesting phenomenon where a disproportionate number of differentially expressed genes reside on the same chromosome as a mutated gene. Here, we provide strong evidence supporting that the differential expression of some of these chromosomally co-located genes is not due to the mutation but is due to differential segregation of gene alleles with innately different expression levels (i.e. expression quantitative trait loci, eQTLs). We have developed a procedure to measure the likelihood of differential gene expression being due to an eQTL. This allows us to compensate for the presence of such eQTLs in bioinformatic analyses. Our procedure, Differential Allelic Representation (DAR) analysis, revealed evidence for aggregation of genes with related functions on the same chromosome over evolutionary timescales. DAR analysis allows disentanglement of eQTLs from mutation-dependent gene expression responses, thereby permitting more comprehensive investigation of transcriptome data. [ABSTRACT FROM AUTHOR]

Published
2024
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37. Radiation Hybrid Mapping of the Zebrafish Genome

Author

Hukriede, Neil A., Joly, Lucille, Tsang, Michael, Miles, Jennifer, Tellis, Patricia, Epstein, Jonathan A., Barbazuk, William B., Li, Frank N., Paw, Barry, Postlethwait, John H., Hudson, Thomas J., Zon, Leonard I., McPherson, John D., Chevrette, Mario, Dawid, Igor B., Johnson, Stephen L., and Ekker, Marc

Published
1999

39. Zebrafish hox Clusters and Vertebrate Genome Evolution

Author

Amores, Angel, Force, Allan, Yan, Yi-Lin, Joly, Lucille, Amemiya, Chris, Fritz, Andreas, Ho, Robert K., Langeland, James, Prince, Victoria, Wang, Yan-Ling, Westerfield, Monte, Ekker, Marc, and Postlethwait, John H.

Published
1998

40. Genomics of cold adaptations in the Antarctic notothenioid fish radiation

Author

Bista, Iliana, Wood, Jonathan M.D., Desvignes, Thomas, McCarthy, Shane A., Matschiner, Michael, Ning, Zemin, Tracey, Alan, Torrance, James, Sims, Ying, Chow, William, Smith, Michelle, Oliver, Karen, Haggerty, Leanne, Salzburger, Walter, Postlethwait, John H., Howe, Kerstin, Clark, Melody S., Detrich III, William H., Cheng, C.-H. Christina, Miska, Eric A., Durbin, Richard, Bista, Iliana, Wood, Jonathan M.D., Desvignes, Thomas, McCarthy, Shane A., Matschiner, Michael, Ning, Zemin, Tracey, Alan, Torrance, James, Sims, Ying, Chow, William, Smith, Michelle, Oliver, Karen, Haggerty, Leanne, Salzburger, Walter, Postlethwait, John H., Howe, Kerstin, Clark, Melody S., Detrich III, William H., Cheng, C.-H. Christina, Miska, Eric A., and Durbin, Richard

Abstract

Numerous novel adaptations characterise the radiation of notothenioids, the dominant fish group in the freezing seas of the Southern Ocean. To improve understanding of the evolution of this iconic fish group, here we generate and analyse new genome assemblies for 24 species covering all major subgroups of the radiation, including five long-read assemblies. We present a new estimate for the onset of the radiation at 10.7 million years ago, based on a time-calibrated phylogeny derived from genome-wide sequence data. We identify a two-fold variation in genome size, driven by expansion of multiple transposable element families, and use the long-read data to reconstruct two evolutionarily important, highly repetitive gene family loci. First, we present the most complete reconstruction to date of the antifreeze glycoprotein gene family, whose emergence enabled survival in sub-zero temperatures, showing the expansion of the antifreeze gene locus from the ancestral to the derived state. Second, we trace the loss of haemoglobin genes in icefishes, the only vertebrates lacking functional haemoglobins, through complete reconstruction of the two haemoglobin gene clusters across notothenioid families. Both the haemoglobin and antifreeze genomic loci are characterised by multiple transposon expansions that may have driven the evolutionary history of these genes.

Published
2023

41. Atypical Alexander disease with dystonia, retinopathy, and a brain mass mimicking astrocytoma

Author

Machol, Keren, Jankovic, Joseph, Vijayakumar, Dhanya, Burrage, Lindsay C., Jain, Mahim, Lewis, Richard A., Fuller, Gregory N., Xu, Mingchu, Penas-Prado, Marta, Gule-Monroe, Maria K., Rosenfeld, Jill A., Chen, Rui, Eng, Christine M., Yang, Yaping, Lee, Brendan H., Moretti, Paolo M., Dhar, Shweta U., Alejandro, Mercedes E., Azamian, Mahshid S., Bacino, Carlos A., Balasubramanyam, Ashok, Bostwick, Bret L., Burrage, Lindsay C., Chen, Shan, Clark, Gary D., Craigen, William J., Dhar, Shweta U., Emrick, Lisa T., Goldman, Alica M., Hanchard, Neil A., Jamal, Fariha, Karaviti, Lefkothea, Lalani, Seema R., Lee, Brendan H., Lewis, Richard A., Marom, Ronit, Moretti, Paolo M., Murdock, David R., Nicholas, Sarah K., Orange, Jordan S., Orengo, James P., Posey, Jennifer E., Potocki, Lorraine, Rosenfeld, Jill A., Samson, Susan L., Scott, Daryl A., Tran, Alyssa A., Vogel, Tiphanie P., Bellen, Hugo J., Wangler, Michael F., Yamamoto, Shinya, Eng, Christine M., Muzny, Donna M., Ward, Patricia A., Yang, Yaping, Goldstein, David B., Stong, Nicholas, Cope, Heidi, Jiang, Yong-hui, McConkie-Rosell, Allyn, Pena, Loren DM., Schoch, Kelly, Shashi, Vandana, Spillmann, Rebecca C., Sullivan, Jennifer A., Tan, Queenie K.G., Walley, Nicole M., Aaron, Aday, Beggs, Alan H., Briere, Lauren C., Cooper, Cynthia M., Donnell-Fink, Laurel A., High, Francis, Korrick, Susan, Krieg, Elizabeth L., Krier, Joel B., Lincoln, Sharyn A., Loscalzo, Joseph, Maas, Richard L., MacRae, Calum A., Pallais, J. Carl, Rodan, Lance H., Silverman, Edwin K., Stoler, Joan M., Sweetser, David A., Walker, Melissa, Walsh, Chris A., Esteves, Cecilia, Glanton, Emily, Holm, Ingrid A., Kohane, Isaac S., McCray, Alexa T., Might, Matthew, LeBlanc, Kimberly, Bick, David P., Birch, Camille L., Boone, Braden E., Brown, Donna M., Dorset, Daniel C., Handley, Lori H., Jones, Angela L., Lazar, Jozef, Levy, Shawn E., May, Thomas, Newberry, J. Scott, Schroeder, Molly C., Worthey, Elizabeth A., Batzli, Gabriel F., Dayal, Jyoti G., Eckstein, David J., Gould, Sarah E., Howerton, Ellen M., Krasnewich, Donna M., Mamounas, Laura A., Manolio, Teri A., Mulvihill, John J., Urv, Tiina K., Wise, Anastasia L., Brush, Matthew, Gourdine, Jean-Philippe F., Haendel, Melissa, Koeller, David M., Kyle, Jennifer E., Metz, Thomas O., Waters, Katrina M., Webb-Robertson, Bobbie-Jo M., Ashley, Euan A., Bernstein, Jonathan A., Bonner, Devon, Coakley, Terra R., Davidson, Jean M., Dries, Annika M., Enns, Gregory M., Fernandez, Liliana, Fisher, Paul G., Friedman, Noah D., Hom, Jason, Huang, Yong, Kohler, Jennefer N., Majcherska, Marta M., Marwaha, Shruti, McCormack, Colleen E., Merker, Jason D., Reuter, Chloe M., Sampson, Jacinda B., Smith, Kevin S., Waggott, Daryl M., Wheeler, Matthew T., Zastrow, Diane B., Zhao, Chunli, Allard, Patrick, Barseghyan, Hayk, Butte, Manish J., DellʼAngelica, Esteban C., Dipple, Katrina M., Dorrani, Naghmeh, Douine, Emilie D., Eskin, Ascia, Fogel, Brent L., Herzog, Matthew R., Lee, Hane, Loo, Sandra K., Martin, Martin G., Martínez-Agosto, Julian A., Nelson, Stan F., Palmer, Christina GS., Papp, Jeanette C., Parker, Neil H., Sinsheimer, Janet S., Vilain, Eric, Wan, Jijun, Yoon, Amanda J., Zheng, Allison, Behnam, Babak, Burke, Elizabeth A., DʼSouza, Precilla, Davids, Mariska, Draper, David D., Estwick, Tyra, Ferreira, Carlos, Godfrey, Rena A., Groden, Catherine A., Johnston, Jean M., Lau, C. Christopher, Macnamara, Ellen F., Maduro, Valerie V., Markello, Thomas C., Morimoto, Marie, Murphy, Jennifer L., Nehrebecky, Michele E., Novacic, Donna, Pusey, Barbara N., Sharma, Prashant, Toro, Camilo, Valivullah, Zaheer M., Wahl, Colleen E., Yu, Guoyun, Gropman, Andrea L., Adams, David R., Gahl, William A., Malicdan, May Christine V., Tifft, Cynthia J., Wolfe, Lynne A., Postlethwait, John H., Westerfield, Monte, Bican, Anna, Hamid, Rizwan, Newman, John H., Phillips, John A., III, Robertson, Amy K., and Cogan, Joy D.

Published
2018
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44. Genome structures resolve the early diversification of teleost fishes

Author

Parey, Elise, primary, Louis, Alexandra, additional, Montfort, Jerome, additional, Bouchez, Olivier, additional, Roques, Céline, additional, Iampietro, Carole, additional, Lluch, Jerome, additional, Castinel, Adrien, additional, Donnadieu, Cécile, additional, Desvignes, Thomas, additional, Floi Bucao, Christabel, additional, Jouanno, Elodie, additional, Wen, Ming, additional, Mejri, Sahar, additional, Dirks, Ron, additional, Jansen, Hans, additional, Henkel, Christiaan, additional, Chen, Wei-Jen, additional, Zahm, Margot, additional, Cabau, Cédric, additional, Klopp, Christophe, additional, Thompson, Andrew W., additional, Robinson-Rechavi, Marc, additional, Braasch, Ingo, additional, Lecointre, Guillaume, additional, Bobe, Julien, additional, Postlethwait, John H., additional, Berthelot, Camille, additional, Roest Crollius, Hugues, additional, and Guiguen, Yann, additional

Published
2023
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46. Deep conservation of wrist and digit enhancers in fish

Author

Gehrke, Andrew R., Schneider, Igor, de la Calle-Mustienes, Elisa, Tena, Juan J., Gomez-Marin, Carlos, Chandran, Mayuri, Nakamura, Tetsuya, Braasch, Ingo, Postlethwait, John H., Gómez-Skarmeta, José Luis, and Shubin, Neil H.

Published
2015

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