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1. Global wealth disparities drive adherence to COVID-safe pathways in head and neck cancer surgery

Author: Schache, Andrew G, Shaw, Richard, Ho, Michael Wing Sung, Winter, Stuart C, Glasbey, James, Ganly, Ian, Batstone, Martin, Biel, Juan Rey, Nankivell, Paul C, Simon, Christian, Omar, Omar, Simoes, Joana F F, Nepogodiev, Dmitri, Bhangu, Aneel, Pinkney, Tom, McGill, Laura, Perry, Rita, Hughes, Terry, Jackson, Richard, Siaw-Acheampong, Kwabena, Benson, Ruth A, Bywater, Edward, Chaudhry, Daoud, Dawson, Brett E, Evans, Jonathan P, Glasbey, James C, Gujjuri, Rohan R, Heritage, Emily, Jones, Conor S, Kamarajah, Sivesh K, Khatri, Chetan, Khaw, Rachel A, Keatley, James M, Knight, Andrew, Lawday, Samuel, Li, Elizabeth, Mann, Harvinder S, Marson, Ella J, McLean, Kenneth A, Mckay, Siobhan C, Mills, Emily C, Pellino, Gianluca, Picciochi, Maria, Taylor, Elliott H, Tiwari, Abhinav, Trout, Isobel M, Venn, Mary L, Wilkin, Richard J W, Ho, Michael W S, Nankivell, Paul, Abbott, Tom E F, Adamina, Michel, Ademuyiwa, Adesoji O, Agarwal, Arnav, Alameer, Ehab, Alderson, Derek, Alakaloko, Felix, Albertsmeiers, Markus, Alser, Osaid, Alshaar, Muhammad, Alshryda, Sattar, Arnaud, Alexis P, Augestad, Knut Magne, Ayasra, Faris, Azevedo, José, Bankhead-Kendall, Brittany K, Barlow, Emma, Blanco-Colino, Ruth, Brar, Amanpreet, Minaya-Bravo, Ana, Breen, Kerry A, Bretherton, Chris, Buarque, Igor Lima, Burke, Joshua, Caruana, Edward J, Chaar, Mohammad, Chakrabortee, Sohini, Christensen, Peter, Cox, Daniel, Cukier, Moises, Cunha, Miguel F, Davidson, Giana H, Desai, Anant, Saverio, Salomone Di, Drake, Thomas M, Edwards, John G, Elhadi, Muhammed, Emile, Sameh, Farik, Shebani, Fiore, Marco, Edward Fitzgerald, J, Ford, Samuel, Garmanova, Tatiana, Gallo, Gaetano, Ghosh, Dhruv, Gomes, Gustavo Mendonça Ataíde, Grecinos, Gustavo, Griffiths, Ewen A, Gründl, Madalegna, Halkias, Constantine, Harrison, Ewen M, Hisham, Intisar, Hutchinson, Peter J, Hwang, Shelley, Isik, Arda, Jenkinson, Michael D, Jonker, Pascal, Kaafarani, Haytham M A, Kolias, Angelos, Kruijff, Schelto, Lawani, Ismail, Lederhuber, Hans, Leventoglu, Sezai, Litvin, Andrey, Loehrer, Andrew, Löffler, Markus W, Lorena, Maria Aguilera, Madolo, Maria Marta, Major, Piotr, Martin, Janet, Mashbari, Hassan N, Mazingi, Dennis, Metallidis, Symeon, Mohan, Helen M, Moore, Rachel, Moszkowicz, David, Moug, Susan, Ng-Kamstra, Joshua S, Maimbo, Mayaba, Niquen, Milagros, Ntirenganya, Faustin, Olivos, Maricarmen, Oussama, Kacimi, Outani, Oumaima, Parreno-Sacdalanm, Marie Dione, Pata, Francesco, Rivera, Carlos Jose Perez, Pinkney, Thomas D, van der Plas, Willemijn, Pockney, Peter, Qureshi, Ahmad, Radenkovic, Dejan, Medina, Antonio Ramos-De la, Roberts, Keith, Roslani, April C, Rutegård, Martin, Santos, Irène, Satoi, Sohei, Sayyed, Raza, Schache, Andrew, Schnitzbauer, Andreas A, Seyi-Olajide, Justina O, Sharma, Neil, Shu, Sebastian, Soreide, Kjetil, Spinelli, Antonino, Stewart, Grant D, Sund, Malin, Sundar, Sudha, Tabiri, Stephen, Townend, Philip, Tsoulfas, Georgios, van Ramshorst, Gabrielle H, Vidya, Raghavan, Vimalachandran, Dale, Warren, Oliver J, Wedderburn, Duane, Wright, Naomi, Boccalatte, L A, Batstone, M, Hodge, R, Abeloos, J, De Backer, T, De Ceulaer, J, Dick, C, Diez-Fraile, A, Lamoral, P, Spaas, C, Schrijvers, D L A L, Willemse, E B M, Faris, C, Maariën, S, Van Haesendonck, G, Van Laer, C, Deron, P, Abdallah, E A, Carvalho, G B, Kowalski, L, Vartanian, J, Gatti, A P, Nardi, C N, Oliva, R N L, Salem, M C, Cheng, D, MacNeil, D, Martin, J, Mayer, R, Groot, G, Acosta, L, Mejia, M, Perez, C J, Lorencin, M, Luksic, I, Mamic, M, Ashoush, F M, Osman, N A, Safwat Shahine, M, Eldaly, A, Elfiky, M M A, Amin, A, Elmorsi, R, Refky, B, Essa, M M, Mengistu, G Mengesha, Dakpé, S, Boucher, S, Ballouhey, Q, Laloze, J, Usseglio, J, Hoffmann, C, Gregoire, V, Lallemant, B, Blaurock, M, Reim, D, Boehm, A, Guntinas-Lichius, O, Hölzle, F, Modabber, A, Winnand, P, Kleeff, J, Lorenz, K, Ronellenfitsch, U, Schneider, R, Betz, C S, Böttcher, A, Busch, C, Möckelmann, N, Inhestern, J M, Greve, J, Hoffmann, T K, Laban, S, Vahl, J M, Agyeman-Prempeh, A, Aning, D, Barnor, I, Darko-Asante, R, Dzogbefia, M, Gaveh, V, Gyimah, D, Issahalq, M D, Konney, A, Poku, M, Adjeso, T, Akornor, E T, Amankwaa, W O, Antwi, D A, Apppiah-Thompson, P, Damah, M, Kumi, E O, Manan, L, Murphy, J P, Osei, L, Setuagbe, J, Arkadopoulos, N, Danias, N, Economopoulou, P, Frountzas, M, Kokoropoulos, P, Larentzakis, A, Michalopoulos, N V, Nastos, K, Parasyris, S, Pikoulis, E, Selmani, J, Sidiropoulos, T A, Vassiliu, P, Kalfountzos, C E, Chatziioannou, I, Corais, C, Gkrinia, E, Ntziovara, A, Saratziotis, A, Antoniadis, K, Orestis, O, Tatsis, D, Baili, E, Charalabopoulos, A, Liakakos, T, Schizas, D, Spartalis, E, Syllaios, A, Zografos, C, Aguilera-Arévalo, M, Misra, S, Pareek, P, Vishnoi, J, Chappity, P, Kar, M, Muduly, D K, Sultania, M, Agarwal, S, Garg, P K, Maharaj, D D, Majumdar, K S, Mishra, N, Poonia, D, Seenivasagam, R K, Singh, M P, Tiwari, A R, Penumadu, P, Rajan, S, Kumar, S, Raychowdhury, R, Ghodke, R, Barry, C, Callanan, D, Dias, A, Haung, L, Ionescu, A, Sheahan, P, Lennon, P, Fitzgerald, C, Mizrachi, A, Deganello, A, Pellini, R, Pichi, B, Lemma, F, Marino, M V, Bergonzani, M, Varazzani, A, Bussu, F, Perra, T, Piras, A, Porcu, A, Rizzo, D, Campisi, G, Cordova, A, Franza, M, Rinaldi, G, Toia, F, Gianni, A, Giannini, L, Gordini, L, Baldini, E, Conti, L, De Virgilio, A, Ferreli, F, Gaino, F, Mercante, G, Spriano, G, Ansarin, M, Chu, F, De Berardinis, R, Ietrobon, G, Tagliabue, M, Ionna, F, Baietti, A, Maremonti, P, Neri, F, Prucher, G, Ricci, S, Casaril, A, Nama, M, Cotoia, A, Lizzi, V, Vovola, F, Bruzzaniti, P, Familiari, P, Lapolla, P, Marruzzo, G, Mingoli, A, Ribuffo, D, Cipriani, R, Contedini, F, Lauretta, M, Marchetti, C, Melotti, M, Pignatti, M, Pinto, V, Pizzigallo, A, Ricotta, F, Tarsitano, A, Catarzi, L, Consorti, G, Abdulwahed, E A, Alshareea, E A, Biala, M I, Ghmagh, R J, Ibrahim, A F, Liew, Y T, Alvarez, M R, Arrangoiz, R, Cordera, F, Gómez-Pedraza, A, Soulé-Martínez, C E, Becerril, O S, Becerra, GFC, Arkha, Y, Bechri, H, El Ouahabi, A, Oudrhiri, M, Benkabbou, A, Majbar, M, Mohsine, R, Souadka, A, Lageju, N, Schreuder, W H, Hardillo, J, de Bree, R, Schweitzer, D, Adeyeye, A A, Enoch, E E, Sholadoye, T S T T, Wuraola, F, Oyelakin, O, Khokhar, M I, Ayub, B, Walędziak, M, Szewczyk, M, Faria, C, Cardoso, P, Castro Silva, J, AlKharashi, E, Jelovac, D, Petrovic, M, Sumrak, S, Asceric, R R, Bojicic, J M, Kovacevic, B M, Krdzic, I D, Milentijevic, M A, Milutinovic, V Z, Stefanovic, Z B, Villacampa, J M, Jiménez Carneros, V, Salazar Carrasco, A, Carabias Hernandez, A, Alonso Lamberti, L, León Ledesma, R, Jiménez Miramón, F J, Jover Navalón, J M, Garcia Quijada, J, Ramos Rodriguez, J, Valle Rubio, A, Vilaseca, I, Escartin, J, Estaire-Gomez, M, Padilla Valverde, D, Tousidonis, M, Lopez, F, Deandrés-Olabarria, U, Durán-Ballesteros, M, Fernández-Pablos, F, Ibáñez-Aguirre, F, Sanz-Larrainzar, A, Ugarte-Sierra, B, Di Martino, M, Prada, J, Jariod-Ferrer, U M, Landaluce Olavarria, A, Rey-Biel, J, Díaz de Cerio, P, Sánchez Barrueco, A, Lindqvist, E K, Sund, M, Piantanida, R, Giger, R, Hool, S, Müller, S A, Stoeckli, S J, Simon, C, Toutounji, T, Al assaf, A, Hammed, A M, Hammed, S M, Mahfoud, M, Arikan, A, Yalkin, Ö, İflazoğlu, N, Isik, A, Leventoglu, S, Aydemir, L, Basaran, B, Sen, C, Comert -Ulusan, M, Saracoglu, K T, Saracoglu, A, Mantoglu, B, Kucuk, G, Aygun, N, Baran, E, Tanal, M, Eray Tufan, A, Uludag, M, Gürkan Yetkin, S, Yigit, B, Calik, B, Demirli Atici, S, Kaya, T, Sikakulya, F K, Abdel-Galil, K M A H, Lowe, T, Durrani, A J, Habeeb, A, Irune, E, Luke, L, Masterson, L, Murphy, S H, Segaren, N, Walker, C, Waseem, S, Jones, T M, Loh, C, Pringle, S, Schache, A G, Shaw, R J, Stenhouse, J, Armstrong, M, Sood, S, Sutton, D, Thomas, S, Clarke, P, Winter, S C, Hislop, S, Counter, P R, Ghazali, N, Lloyd, C, Prabhu, V, Godden, D, Whitley, S, Butler, C, Nash, R, El-Boghdadly, K, Fry, A, Niziol, R, De, M, Gill, C K, Crank, S, Mace, A D, Ho, M, Mair, M, Kothari, P, Homer, J, Sainuddin, S, Egan, R J, Kittur, M, Burgess, C, O'Hara, J, Manickavasagam, J, McDonald, C, Burrows, S, Java, K R, Katre, C, Ahmed, A, Siddique, H, King, E, Ramchandani, P, Naredla, P R, Brennan, P, Ringrose, T, Schmidt, F, Mak, J K C, Nankivell, P, Parmar, S, Sharma, N, Douglas, C, McCaul, J, Dhanda, J, Kyzas, P, Vassiliou, L, Kumar, A, Husband, A, Hulbert, J, Ingrams, D, Parkin, R, Varley, I, Gahir, D, George, A, Zakai, D, Bater, M, Surwald, C, Devlin, B, Leonard, C G, Pigadas, N, Snee, D, Singh, R P, Hyde, N C, Paley, M, Cocks, H, Wilson, A, Choi, D, Kerawala, C J, Riva, F, Dickason, A, Semple, C J, Schilling, C, Walton, G, Rees-Stoner, O, Scott, N, Nixon, I J, Tighe, D, Mattine, S, Chu, M M H, Pothula, V, Lee, W, Brown, L, Ganly, I, Alpert, N, Illezeau, C N, Miles, B, Rapp, J, Taioli, E, Azam, M T, Choudhry, A J, Marx, W, Stein, J, Ying, Y, Gross, N D, Almasri, M, Joshi, R, Kulkarni, G, Marwan, H, Mehdi, M, Sumer, B, Department of Surgery, HUS Abdominal Center, Schache, Andrew G., Shaw, Richard, Omar, Omar, Emile, Sameh, Farik, Shebani, Fiore, Marco, Edward Fitzgerald, J., Ford, Samuel, Garmanova, Tatiana, Gallo, Gaetano, Ghosh, Dhruv, Gomes, Gustavo Mendonça Ataíde, Grecinos, Gustavo, Simoes, Joana F. F., Griffiths, Ewen A., Gründl, Madalegna, Halkias, Constantine, Harrison, Ewen M., Hisham, Intisar, Hutchinson, Peter J., Hwang, Shelley, Isik, Arda, Jenkinson, Michael D., Jonker, Pascal, Nepogodiev, Dmitri, Kaafarani, Haytham M. A., Kolias, Angelos, Kruijff, Schelto, Lawani, Ismail, Lederhuber, Hans, Leventoglu, Sezai, Litvin, Andrey, Loehrer, Andrew, Löffler, Markus W., Lorena, Maria Aguilera, Bhangu, Aneel, Madolo, Maria Marta, Major, Piotr, Martin, Janet, Mashbari, Hassan N., Mazingi, Dennis, Metallidis, Symeon, Minaya-Bravo, Ana, Mohan, Helen M., Moore, Rachel, Moszkowicz, David, Pinkney, Tom, Moug, Susan, Ng-Kamstra, Joshua S., Maimbo, Mayaba, Niquen, Milagros, Ntirenganya, Faustin, Olivos, Maricarmen, Oussama, Kacimi, Outani, Oumaima, Parreno-Sacdalanm, Marie Dione, Pata, Francesco, McGill, Laura, Rivera, Carlos Jose Perez, Pinkney, Thomas D., van der Plas, Willemijn, Pockney, Peter, Qureshi, Ahmad, Radenkovic, Dejan, Medina, Antonio Ramos-De la, Roberts, Keith, Roslani, April C., Rutegård, Martin, Perry, Rita, Santos, Irène, Satoi, Sohei, Sayyed, Raza, Schache, Andrew, Schnitzbauer, Andreas A., Seyi-Olajide, Justina O., Sharma, Neil, Shu, Sebastian, Soreide, Kjetil, Hughes, Terry, Spinelli, Antonino, Stewart, Grant D., Sund, Malin, Sundar, Sudha, Tabiri, Stephen, Townend, Philip, Tsoulfas, Georgios, van Ramshorst, Gabrielle H., Vidya, Raghavan, Vimalachandran, Dale, Jackson, Richard, Warren, Oliver J., Wedderburn, Duane, Wright, Naomi, Boccalatte, L. A., Batstone, M., Hodge, R., Abeloos, J., De Backer, T., De Ceulaer, J., Dick, C., Siaw-Acheampong, Kwabena, Diez-Fraile, A., Lamoral, P., Spaas, C., Schrijvers, D. L. A. L., Willemse, E. B. M., Faris, C., Maariën, S., Van Haesendonck, G., Van Laer, C., Deron, P., Ho, Michael Wing Sung, Benson, Ruth A., Abdallah, E. A., Carvalho, G. B., Kowalski, L., Vartanian, J., Gatti, A. P., Nardi, C. N., Oliva, R. N. L., Salem, M. C., Cheng, D., MacNeil, D., Bywater, Edward, Martin, J., Mayer, R., Groot, G., Acosta, L., Mejia, M., Perez, C. J., Lorencin, M., Luksic, I., Mamic, M., Ashoush, F. M., Chaudhry, Daoud, Osman, N. A., Safwat Shahine, M., Eldaly, A., Elfiky, M. M. A., Amin, A., Elmorsi, R., Refky, B., Essa, M. M., Mengistu, G. Mengesha, Dakpé, S., Dawson, Brett E., Boucher, S., Ballouhey, Q., Laloze, J., Usseglio, J., Hoffmann, C., Gregoire, V., Lallemant, B., Blaurock, M., Reim, D., Boehm, A., Evans, Jonathan P., Guntinas-Lichius, O., Hölzle, F., Modabber, A., Winnand, P., Kleeff, J., Lorenz, K., Ronellenfitsch, U., Schneider, R., Betz, C. S., Böttcher, A., Glasbey, James C., Busch, C., Möckelmann, N., Inhestern, J. M., Greve, J., Hoffmann, T. K., Laban, S., Vahl, J. M., Agyeman-Prempeh, A., Aning, D., Barnor, I., Gujjuri, Rohan R., Darko-Asante, R., Dzogbefia, M., Gaveh, V., Gyimah, D., Issahalq, M. D., Konney, A., Poku, M., Adjeso, T., Akornor, E. T., Amankwaa, W. O., Heritage, Emily, Antwi, D. A., Apppiah-Thompson, P., Damah, M., Kumi, E. O., Manan, L., Murphy, J. P., Osei, L., Setuagbe, J., Arkadopoulos, N., Danias, N., Jones, Conor S., Economopoulou, P., Frountzas, M., Kokoropoulos, P., Larentzakis, A., Michalopoulos, N. V., Nastos, K., Parasyris, S., Pikoulis, E., Selmani, J., Sidiropoulos, T. A., Kamarajah, Sivesh K., Vassiliu, P., Kalfountzos, C. E., Chatziioannou, I., Corais, C., Gkrinia, E., Ntziovara, A., Saratziotis, A., Antoniadis, K., Orestis, O., Tatsis, D., Winter, Stuart C., Khatri, Chetan, Baili, E., Charalabopoulos, A., Liakakos, T., Schizas, D., Spartalis, E., Syllaios, A., Zografos, C., Aguilera-Arévalo, M., Misra, S., Pareek, P., Khaw, Rachel A., Vishnoi, J., Chappity, P., Kar, M., Muduly, D. K., Sultania, M., Agarwal, S., Garg, P. K., Maharaj, D. D., Majumdar, K. S., Mishra, N., Keatley, James M., Poonia, D., Seenivasagam, R. K., Singh, M. P., Tiwari, A. R., Penumadu, P., Rajan, S., Kumar, S., Raychowdhury, R., Ghodke, R., Knight, Andrew, Barry, C., Callanan, D., Dias, A., Haung, L., Ionescu, A., Sheahan, P., Lennon, P., Fitzgerald, C., Mizrachi, A., Deganello, A., Lawday, Samuel, Pellini, R., Pichi, B., Lemma, F., Marino, M. V., Bergonzani, M., Varazzani, A., Bussu, F., Perra, T., Piras, A., Porcu, A., Li, Elizabeth, Rizzo, D., Campisi, G., Cordova, A., Franza, M., Rinaldi, G., Toia, F., Gianni, A., Giannini, L., Gordini, L., Baldini, E., Mann, Harvinder S., Conti, L., De Virgilio, A., Ferreli, F., Gaino, F., Mercante, G., Spriano, G., Ansarin, M., Chu, F., De Berardinis, R., Ietrobon, G., Marson, Ella J., Tagliabue, M., Ionna, F., Baietti, A., Maremonti, P., Neri, F., Prucher, G., Ricci, S., Casaril, A., Nama, M., Cotoia, A., McLean, Kenneth A., Lizzi, V., Vovola, F., Bruzzaniti, P., Familiari, P., Lapolla, P., Marruzzo, G., Mingoli, A., Ribuffo, D., Cipriani, R., Contedini, F., Mckay, Siobhan C., Lauretta, M., Marchetti, C., Melotti, M., Pignatti, M., Pinto, V., Pizzigallo, A., Ricotta, F., Tarsitano, A., Catarzi, L., Abdulwahed, E. A., Glasbey, James, Mills, Emily C., Alshareea, E. A., Biala, M. I., Ghmagh, R. J., Ibrahim, A. F., Liew, Y. T., Alvarez, M. R., Arrangoiz, R., Cordera, F., Gómez-Pedraza, A., Soulé-Martínez, C. E., Becerril, O. S., Becerra, Gfc, Arkha, Y., Bechri, H., El Ouahabi, A., Oudrhiri, M., Benkabbou, A., Majbar, M., Mohsine, R., Souadka, A., Pellino, Gianluca, Lageju, N., Schreuder, W. H., Hardillo, J., de Bree, R., Schweitzer, D., Adeyeye, A. A., Enoch, E. E., Sholadoye, T. S. T. T., Wuraola, F., Oyelakin, O., Picciochi, Maria, Khokhar, M. I., Ayub, B., Walędziak, M., Szewczyk, M., Faria, C., Cardoso, P., Castro Silva, J., AlKharashi, E., Jelovac, D., Petrovic, M., Taylor, Elliott H., Sumrak, S., Asceric, R. R., Bojicic, J. M., Kovacevic, B. M., Krdzic, I. D., Milentijevic, M. A., Milutinovic, V. Z., Stefanovic, Z. B., Villacampa, J. M., Jiménez Carneros, V., Tiwari, Abhinav, Salazar Carrasco, A., Carabias Hernandez, A., Alonso Lamberti, L., León Ledesma, R., Jiménez Miramón, F. J., Jover Navalón, J. M., Garcia Quijada, J., Ramos Rodriguez, J., Valle Rubio, A., Vilaseca, I., Escartin, J., Estaire-Gomez, M., Padilla Valverde, D., Tousidonis, M., Lopez, F., Deandrés-Olabarria, U., Durán-Ballesteros, M., Fernández-Pablos, F., Ibáñez-Aguirre, F., Sanz-Larrainzar, A., Trout, Isobel M., Ugarte-Sierra, B., Di Martino, M., Prada, J., Jariod-Ferrer, U. M., Landaluce Olavarria, A., Rey-Biel, J., Díaz de Cerio, P., Sánchez Barrueco, A., Lindqvist, E. K., Sund, M., Venn, Mary L., Piantanida, R., Giger, R., Hool, S., Müller, S. A., Stoeckli, S. J., Simon, C., Toutounji, T., Al Assaf, A., Hammed, A. M., Hammed, S. M., Wilkin, Richard J. W., Mahfoud, M., Arikan, A., Yalkin, Ö, İflazoğlu, N., Isik, A., Leventoglu, S., Aydemir, L., Basaran, B., Sen, C., Comert-Ulusan, M., Ganly, Ian, Saracoglu, K. T., Saracoglu, A., Mantoglu, B., Kucuk, G., Aygun, N., Baran, E., Tanal, M., Eray Tufan, A., Uludag, M., Gürkan Yetkin, S., Yigit, B., Calik, B., Demirli Atici, S., Kaya, T., Sikakulya, F. K., Abdel-Galil, K. M. A. H., Lowe, T., Durrani, A. J., Habeeb, A., Irune, E., Luke, L., Masterson, L., Murphy, S. H., Segaren, N., Walker, C., Waseem, S., Jones, T. M., Loh, C., Pringle, S., Schache, A. G., Shaw, R. J., Stenhouse, J., Armstrong, M., Sood, S., Sutton, D., Thomas, S., Clarke, P., Winter, S. C., Hislop, S., Counter, P. R., Ghazali, N., Lloyd, C., Prabhu, V., Godden, D., Whitley, S., Butler, C., Nash, R., El-Boghdadly, K., Fry, A., Ho, Michael W. S., Niziol, R., De, M., Gill, C. K., Crank, S., Mace, A. D., Ho, M., Mair, M., Kothari, P., Homer, J., Sainuddin, S., Nankivell, Paul, Egan, R. J., Kittur, M., Burgess, C., O'Hara, J., Manickavasagam, J., McDonald, C., Burrows, S., Java, K. R., Katre, C., Ahmed, A., Biel, Juan Rey, Siddique, H., King, E., Ramchandani, P., Naredla, P. R., Brennan, P., Ringrose, T., Schmidt, F., Mak, J. K. C., Nankivell, P., Parmar, S., Batstone, Martin, Sharma, N., Douglas, C., McCaul, J., Dhanda, J., Kyzas, P., Vassiliou, L., Kumar, A., Husband, A., Hulbert, J., Ingrams, D., Parkin, R., Varley, I., Gahir, D., George, A., Zakai, D., Bater, M., Surwald, C., Devlin, B., Simon, Christian, Leonard, C. G., Pigadas, N., Snee, D., Singh, R. P., Hyde, N. C., Paley, M., Cocks, H., Wilson, A., Choi, D., Kerawala, C. J., Riva, F., Dickason, A., Semple, C. J., Schilling, C., Walton, G., Rees-Stoner, O., Scott, N., Nixon, I. J., Tighe, D., Abbott, Tom E. F., Mattine, S., Chu, M. M. H., Pothula, V., Lee, W., Brown, L., Ganly, I., Alpert, N., Illezeau, C. N., Miles, B., Rapp, J., Adamina, Michel, Taioli, E., Azam, M. T., Choudhry, A. J., Marx, W., Stein, J., Ying, Y., Gross, N. D., Almasri, M., Joshi, R., Kulkarni, G., Ademuyiwa, Adesoji O., Marwan, H., Mehdi, M., Sumer, B., Consorti, Giuseppe, Agarwal, Arnav, Alameer, Ehab, Alderson, Derek, Alakaloko, Felix, Albertsmeiers, Markus, Alser, Osaid, Alshaar, Muhammad, Alshryda, Sattar, Arnaud, Alexis P., Augestad, Knut Magne, Ayasra, Faris, Azevedo, José, Bankhead-Kendall, Brittany K., Barlow, Emma, Nankivell, Paul C., Blanco-Colino, Ruth, Brar, Amanpreet, Breen, Kerry A., Bretherton, Chris, Buarque, Igor Lima, Burke, Joshua, Caruana, Edward J., Chaar, Mohammad, Chakrabortee, Sohini, Christensen, Peter, Cox, Daniel, Cukier, Moises, Cunha, Miguel F., Davidson, Giana H., Desai, Anant, Di Saverio, Salomone, Drake, Thomas M., Edwards, John G., Elhadi, Muhammed, Collaborative, COVIDSurg, COVIDSurg Collaborative, EuroSurg, European Soc Coloproctology ESCP, Global Initiative Childrens Surg G, GlobalSurg, GlobalPaedSurg, ItSURG, PTSurg, SpainSurg, Italian Soc Colorectal Surg SICCR, Assoc Surg Training ASiT, Irish Surg Res Collaborative ISRC, Transatlantic Australasian Retrope, Italian Soc Surg Oncology SICO, Schache, Andrew G, Winter, Stuart C, Glasbey, Jame, Nankivell, Paul C, Simoes, Joana F F, Benson, Ruth A, Dawson, Brett E, Evans, Jonathan P, Glasbey, James C, Gujjuri, Rohan R, Jones, Conor S, Kamarajah, Sivesh K, Khaw, Rachel A, Keatley, James M, Mann, Harvinder S, Marson, Ella J, McLean, Kenneth A, Mckay, Siobhan C, Mills, Emily C, Taylor, Elliott H, Trout, Isobel M, Venn, Mary L, Wilkin, Richard J W, Ho, Michael W S, Abbott, Tom E F, Ademuyiwa, Adesoji O, Albertsmeiers, Marku, Arnaud, Alexis P, Ayasra, Fari, Bankhead-Kendall, Brittany K, Breen, Kerry A, Bretherton, Chri, Caruana, Edward J, Cukier, Moise, Cunha, Miguel F, Davidson, Giana H, Saverio, Salomone Di, Drake, Thomas M, Edwards, John G, Edward Fitzgerald, J, Griffiths, Ewen A, Harrison, Ewen M, Hutchinson, Peter J, Jenkinson, Michael D, Kaafarani, Haytham M A, Kolias, Angelo, Lederhuber, Han, Löffler, Markus W, Mashbari, Hassan N, Mazingi, Denni, Mohan, Helen M, Ng-Kamstra, Joshua S, Niquen, Milagro, Pinkney, Thomas D, Roslani, April C, Schnitzbauer, Andreas A, Seyi-Olajide, Justina O, Stewart, Grant D, Tsoulfas, Georgio, van Ramshorst, Gabrielle H, Warren, Oliver J, Boccalatte, L A, Batstone, M, Hodge, R, Abeloos, J, De Backer, T, De Ceulaer, J, Dick, C, Diez-Fraile, A, Lamoral, P, Spaas, C, Schrijvers, D L A L, Willemse, E B M, Faris, C, Maariën, S, Van Haesendonck, G, Van Laer, C, Deron, P, Abdallah, E A, Carvalho, G B, Kowalski, L, Vartanian, J, Gatti, A P, Nardi, C N, Oliva, R N L, Salem, M C, Cheng, D, MacNeil, D, Martin, J, Mayer, R, Groot, G, Acosta, L, Mejia, M, Perez, C J, Lorencin, M, Luksic, I, Mamic, M, Ashoush, F M, Osman, N A, Safwat Shahine, M, Eldaly, A, Elfiky, M M A, Amin, A, Elmorsi, R, Refky, B, Essa, M M, Mengistu, G Mengesha, Dakpé, S, Boucher, S, Ballouhey, Q, Laloze, J, Usseglio, J, Hoffmann, C, Gregoire, V, Lallemant, B, Blaurock, M, Reim, D, Boehm, A, Guntinas-Lichius, O, Hölzle, F, Modabber, A, Winnand, P, Kleeff, J, Lorenz, K, Ronellenfitsch, U, Schneider, R, Betz, C S, Böttcher, A, Busch, C, Möckelmann, N, Inhestern, J M, Greve, J, Hoffmann, T K, Laban, S, Vahl, J M, Agyeman-Prempeh, A, Aning, D, Barnor, I, Darko-Asante, R, Dzogbefia, M, Gaveh, V, Gyimah, D, Issahalq, M D, Konney, A, Poku, M, Adjeso, T, Akornor, E T, Amankwaa, W O, Antwi, D A, Apppiah-Thompson, P, Damah, M, Kumi, E O, Manan, L, Murphy, J P, Osei, L, Setuagbe, J, Arkadopoulos, N, Danias, N, Economopoulou, P, Frountzas, M, Kokoropoulos, P, Larentzakis, A, Michalopoulos, N V, Nastos, K, Parasyris, S, Pikoulis, E, Selmani, J, Sidiropoulos, T A, Vassiliu, P, Kalfountzos, C E, Chatziioannou, I, Corais, C, Gkrinia, E, Ntziovara, A, Saratziotis, A, Antoniadis, K, Orestis, O, Tatsis, D, Baili, E, Charalabopoulos, A, Liakakos, T, Schizas, D, Spartalis, E, Syllaios, A, Zografos, C, Aguilera-Arévalo, M, Misra, S, Pareek, P, Vishnoi, J, Chappity, P, Kar, M, Muduly, D K, Sultania, M, Agarwal, S, Garg, P K, Maharaj, D D, Majumdar, K S, Mishra, N, Poonia, D, Seenivasagam, R K, Singh, M P, Tiwari, A R, Penumadu, P, Rajan, S, Kumar, S, Raychowdhury, R, Ghodke, R, Barry, C, Callanan, D, Dias, A, Haung, L, Ionescu, A, Sheahan, P, Lennon, P, Fitzgerald, C, Mizrachi, A, Deganello, A, Pellini, R, Pichi, B, Lemma, F, Marino, M V, Bergonzani, M, Varazzani, A, Bussu, F, Perra, T, Piras, A, Porcu, A, Rizzo, D, Campisi, G, Cordova, A, Franza, M, Rinaldi, G, Toia, F, Gianni, A, Giannini, L, Gordini, L, Baldini, E, Conti, L, De Virgilio, A, Ferreli, F, Gaino, F, Mercante, G, Spriano, G, Ansarin, M, Chu, F, De Berardinis, R, Ietrobon, G, Tagliabue, M, Ionna, F, Baietti, A, Maremonti, P, Neri, F, Prucher, G, Ricci, S, Casaril, A, Nama, M, Cotoia, A, Lizzi, V, Vovola, F, Bruzzaniti, P, Familiari, P, Lapolla, P, Marruzzo, G, Mingoli, A, Ribuffo, D, Cipriani, R, Contedini, F, Lauretta, M, Marchetti, C, Melotti, M, Pignatti, M, Pinto, V, Pizzigallo, A, Ricotta, F, Tarsitano, A, Catarzi, L, Consorti, G, Abdulwahed, E A, Alshareea, E A, Biala, M I, Ghmagh, R J, Ibrahim, A F, Liew, Y T, Alvarez, M R, Arrangoiz, R, Cordera, F, Gómez-Pedraza, A, Soulé-Martínez, C E, Becerril, O S, Becerra, GFC, Arkha, Y, Bechri, H, El Ouahabi, A, Oudrhiri, M, Benkabbou, A, Majbar, M, Mohsine, R, Souadka, A, Lageju, N, Schreuder, W H, Hardillo, J, de Bree, R, Schweitzer, D, Adeyeye, A A, Enoch, E E, Sholadoye, T S T T, Wuraola, F, Oyelakin, O, Khokhar, M I, Ayub, B, Walędziak, M, Szewczyk, M, Faria, C, Cardoso, P, Castro Silva, J, AlKharashi, E, Jelovac, D, Petrovic, M, Sumrak, S, Asceric, R R, Bojicic, J M, Kovacevic, B M, Krdzic, I D, Milentijevic, M A, Milutinovic, V Z, Stefanovic, Z B, Villacampa, J M, Jiménez Carneros, V, Salazar Carrasco, A, Carabias Hernandez, A, Alonso Lamberti, L, León Ledesma, R, Jiménez Miramón, F J, Jover Navalón, J M, Garcia Quijada, J, Ramos Rodriguez, J, Valle Rubio, A, Vilaseca, I, Escartin, J, Estaire-Gomez, M, Padilla Valverde, D, Tousidonis, M, Lopez, F, Deandrés-Olabarria, U, Durán-Ballesteros, M, Fernández-Pablos, F, Ibáñez-Aguirre, F, Sanz-Larrainzar, A, Ugarte-Sierra, B, Di Martino, M, Prada, J, Jariod-Ferrer, U M, Landaluce Olavarria, A, Rey-Biel, J, Díaz de Cerio, P, Sánchez Barrueco, A, Lindqvist, E K, Sund, M, Piantanida, R, Giger, R, Hool, S, Müller, S A, Stoeckli, S J, Simon, C, Toutounji, T, Al assaf, A, Hammed, A M, Hammed, S M, Mahfoud, M, Arikan, A, İflazoğlu, N, Isik, A, Leventoglu, S, Aydemir, L, Basaran, B, Sen, C, Comert -Ulusan, M, Saracoglu, K T, Saracoglu, A, Mantoglu, B, Kucuk, G, Aygun, N, Baran, E, Tanal, M, Eray Tufan, A, Uludag, M, Gürkan Yetkin, S, Yigit, B, Calik, B, Demirli Atici, S, Kaya, T, Sikakulya, F K, Abdel-Galil, K M A H, Lowe, T, Durrani, A J, Habeeb, A, Irune, E, Luke, L, Masterson, L, Murphy, S H, Segaren, N, Walker, C, Waseem, S, Jones, T M, Loh, C, Pringle, S, Schache, A G, Shaw, R J, Stenhouse, J, Armstrong, M, Sood, S, Sutton, D, Thomas, S, Clarke, P, Winter, S C, Hislop, S, Counter, P R, Ghazali, N, Lloyd, C, Prabhu, V, Godden, D, Whitley, S, Butler, C, Nash, R, El-Boghdadly, K, Fry, A, Niziol, R, De, M, Gill, C K, Crank, S, Mace, A D, Ho, M, Mair, M, Kothari, P, Homer, J, Sainuddin, S, Egan, R J, Kittur, M, Burgess, C, O'Hara, J, Manickavasagam, J, McDonald, C, Burrows, S, Java, K R, Katre, C, Ahmed, A, Siddique, H, King, E, Ramchandani, P, Naredla, P R, Brennan, P, Ringrose, T, Schmidt, F, Mak, J K C, Nankivell, P, Parmar, S, Sharma, N, Douglas, C, McCaul, J, Dhanda, J, Kyzas, P, Vassiliou, L, Kumar, A, Husband, A, Hulbert, J, Ingrams, D, Parkin, R, Varley, I, Gahir, D, George, A, Zakai, D, Bater, M, Surwald, C, Devlin, B, Leonard, C G, Pigadas, N, Snee, D, Singh, R P, Hyde, N C, Paley, M, Cocks, H, Wilson, A, Choi, D, Kerawala, C J, Riva, F, Dickason, A, Semple, C J, Schilling, C, Walton, G, Rees-Stoner, O, Scott, N, Nixon, I J, Tighe, D, Mattine, S, Chu, M M H, Pothula, V, Lee, W, Brown, L, Ganly, I, Alpert, N, Illezeau, C N, Miles, B, Rapp, J, Taioli, E, Azam, M T, Choudhry, A J, Marx, W, Stein, J, Ying, Y, Gross, N D, Almasri, M, Joshi, R, Kulkarni, G, Marwan, H, Mehdi, M, and Sumer, B
Subjects: AcademicSubjects/MED00910, SARS-CoV-2, pandemic, COVID-19, safe healthcare delivery, education, Bjs/2, General Medicine, 030230 surgery, 3126 Surgery, anesthesiology, intensive care, radiology, 3. Good health, 03 medical and health sciences, fluids and secretions, 0302 clinical medicine, Head and Neck Neoplasms, 030220 oncology & carcinogenesis, parasitic diseases, Research Letter, Humans, head and neck cancer, Human medicine, AcademicSubjects/MED00010, COVID
Abstract: BJS open 5(6), zrab112 (2021). doi:10.1093/bjsopen/zrab112, Published by Oxford University Press, Oxford
Published: 2021

2. MEF2C transcription factor is associated with the genetic and epigenetic risk architecture of schizophrenia and improves cognition in mice

Author: Mitchell, A C, Javidfar, B, Pothula, V, Ibi, D, Shen, E Y, Peter, C J, Bicks, L K, Fehr, T, Jiang, Y, Brennand, K J, Neve, R L, Gonzalez-Maeso, J, and Akbarian, S
Published: 2018
Full Text: View/download PDF

3. Using mTOR Inhibitor Nanoimmunotherapy to Induce Cardiac Allograft Tolerance in Non-Human Primates

Author: O, J.M., primary, Patel, P.M., additional, Teunissen, A.J., additional, Miller, C., additional, Costa, T., additional, Momodu, M., additional, Muldoon, D., additional, Dehnadi, A., additional, Hanekamp, I., additional, Pothula, V., additional, Sanchez-Tarjuelo, R., additional, Prevot, G., additional, Mulder, W.J., additional, Ochando, J., additional, and Madsen, J.C., additional
Published: 2022
Full Text: View/download PDF

4. UK Head and neck cancer surgical capacity during the second wave of the COVID-19 pandemic: Have we learned the lessons? COVIDSurg collaborative

Author: Shaw, Richard, Schache, Andrew G, Ho, Michael Wing Sung, Winter, Stuart C, Glasbey, James, Ganly, Ian, Batstone, Martin, Biel, Juan Rey, Nankivell, Paul C, Simon, Christian, Omar, Omar, Simoes, Joana FF, Nepogodiev, Dmitri, Bhangu, Aneel, Pinkney, Tom, McGill, Laura, Perry, Rita, Hughes, Terry, Siaw-Acheampong, Kwabena, Benson, Ruth A, Bywater, Edward, Chaudhry, Daoud, Dawson, Brett E, Evans, Jonathan P, Glasbey, James C, Gujjuri, Rohan R, Heritage, Emily, Jones, Conor S, Kamarajah, Sivesh K, Khatri, Chetan, Khaw, Rachel A, Keatley, James M, Knight, Andrew, Lawday, Samuel, Li, Elizabeth, Mann, Harvinder S, Marson, Ella J, McLean, Kenneth A, Mckay, Siobhan C, Mills, Emily C, Pellino, Gianluca, Picciochi, Maria, Taylor, Elliott H, Tiwari, Abhinav, Trout, Isobel M, Venn, Mary L, Wilkin, Richard JW, Ho, Michael WS, Nankivell, Paul, Abbott, Tom EF, Adamina, Michel, Ademuyiwa, Adesoji O, Agarwal, Arnav, Alameer, Ehab, Alderson, Derek, Alakaloko, Felix, Albertsmeiers, Markus, Alser, Osaid, Alshaar, Muhammad, Alshryda, Sattar, Arnaud, Alexis P, Augestad, Knut Magne, Ayasra, Faris, Azevedo, José, Bankhead-Kendall, Brittany K, Barlow, Emma, Blanco-Colino, Ruth, Brar, Amanpreet, Minaya-Bravo, Ana, Breen, Kerry A, Bretherton, Chris, Lima Buarque, Igor, Burke, Joshua, Caruana, Edward J, Chaar, Mohammad, Chakrabortee, Sohini, Christensen, Peter, Cox, Daniel, Cukier, Moises, Cunha, Miguel F, Davidson, Giana H, Desai, Anant, Di Saverio, Salomone, Drake, Thomas M, Edwards, John G, Elhadi, Muhammed, Emile, Sameh, Farik, Shebani, Fiore, Marco, Edward Fitzgerald, J, Ford, Samuel, Garmanova, Tatiana, Gallo, Gaetano, Ghosh, Dhruv, Gomes, Gustavo Mendonça Ataíde, Grecinos, Gustavo, Griffiths, Ewen A, Gründl, Madalegna, Halkias, Constantine, Harrison, Ewen M, Hisham, Intisar, Hutchinson, Peter J, Hwang, Shelley, Isik, Arda, Jenkinson, Michael D, Jonker, Pascal, Kaafarani, Haytham MA, Kolias, Angelos, Kruijff, Schelto, Lawani, Ismail, Lederhuber, Hans, Leventoglu, Sezai, Litvin, Andrey, Loehrer, Andrew, Löffler, Markus W, Aguilera Lorena, Maria, Marta Madolo, Maria, Major, Piotr, Martin, Janet, Mashbari, Hassan N, Mazingi, Dennis, Metallidis, Symeon, Mohan, Helen M, Moore, Rachel, Moszkowicz, David, Moug, Susan, Ng-Kamstra, Joshua S, Maimbo, Mayaba, Niquen, Milagros, Ntirenganya, Faustin, Olivos, Maricarmen, Oussama, Kacimi, Outani, Oumaima, Parreno-Sacdalanm, Marie Dione, Pata, Francesco, Rivera, Carlos Jose Perez, Pinkney, Thomas D, Plas, Willemijn, Pockney, Peter, Qureshi, Ahmad, Radenkovic, Dejan, Ramos-De la Medina, Antonio, Roberts, Keith, Roslani, April C, Rutegård, Martin, Santos, Irène, Satoi, Sohei, Sayyed, Raza, Schache, Andrew, Schnitzbauer, Andreas A, Seyi-Olajide, Justina O., Sharma, Neil, Shu, Sebastian, Soreide, Kjetil, Spinelli, Antonino, Stewart, Grant D, Sund, Malin, Sundar, Sudha, Tabiri, Stephen, Townend, Philip, Tsoulfas, Georgios, Ramshorst, Gabrielle H, Vidya, Raghavan, Vimalachandran, Dale, Warren, Oliver J, Wedderburn, Duane, Wright, Naomi, Boccalatte, LA, Batstone, M, Hodge, R, Abeloos, J, De Backer, T, De Ceulaer, J, Dick, C, Diez-Fraile, A, Lamoral, P, Spaas, C, Schrijvers, DLAL, Willemse, EBM, Faris, C, Maariën, S, Van Haesendonck, G, Van Laer, C, Deron, P, Abdallah, EA, Carvalho, GB, Kowalski, L, Vartanian, J, Gatti, AP, Nardi, CN, Oliva, RNL, Salem, MC, Cheng, D, MacNeil, D, Martin, J, Mayer, R, Groot, G, Acosta, L, Mejia, M, Perez, CJ, Lorencin, M, Luksic, I, Mamic, M, Ashoush, FM, Osman, NA, Safwat Shahine, M, Eldaly, A, Elfiky, MMA, Amin, A, Elmorsi, R, Refky, B, Essa, MM, Mengesha, Mengistu G, Dakpé, S, Boucher, S, Ballouhey, Q, Laloze, J, Usseglio, J, Hoffmann, C, Gregoire, V, Lallemant, B, Blaurock, M, Reim, D, Boehm, A, Guntinas-Lichius, O, Hölzle, F, Modabber, A, Winnand, P, Kleeff, J, Lorenz, K, Ronellenfitsch, U, Schneider, R, Betz, CS, Böttcher, A, Busch, C, Möckelmann, N, Inhestern, JM, Greve, J, Hoffmann, TK, Laban, S, Vahl, JM, Agyeman-Prempeh, A, Aning, D, Barnor, I, Darko-Asante, R, Dzogbefia, M, Gaveh, V, Gyimah, D, Issahalq, MD, Konney, A, Poku, M, Adjeso, T, Akornor, ET, Amankwaa, WO, Antwi, DA, Apppiah-Thompson, P, Damah, M, Kumi, EO, Manan, L, Murphy, JP, Osei, L, Setuagbe, J, Arkadopoulos, N, Danias, N, Economopoulou, P, Frountzas, M, Kokoropoulos, P, Larentzakis, A, Michalopoulos, NV, Nastos, K, Parasyris, S, Pikoulis, E, Selmani, J, Sidiropoulos, TA, Vassiliu, P, Kalfountzos, CE, Chatziioannou, I, Corais, C, Gkrinia, E, Ntziovara, A, Saratziotis, A, Antoniadis, K, Orestis, O, Tatsis, D, Baili, E, Charalabopoulos, A, Liakakos, T, Schizas, D, Spartalis, E, Syllaios, A, Zografos, C, Aguilera-Arévalo, M, Misra, S, Pareek, P, Vishnoi, J, Chappity, P, Kar, M, Muduly, DK, Sultania, M, Agarwal, S, Garg, PK, Maharaj, DD, Majumdar, KS, Mishra, N, Poonia, D, Seenivasagam, RK, Singh, MP, Tiwari, AR, Penumadu, P, Rajan, S, Kumar, S, Raychowdhury, R, Ghodke, R, Barry, C, Callanan, D, Dias, A, Haung, L, Ionescu, A, Sheahan, P, Lennon, P, Mizrachi, A, Deganello, A, Pellini, R, Pichi, B, Lemma, F, Marino, MV, Bergonzani, M, Varazzani, A, Bussu, F, Perra, T, Piras, A, Porcu, A, Rizzo, D, Campisi, G, Cordova, A, Franza, M, Rinaldi, G, Toia, F, Gianni, A, Giannini, L, Gordini, L, Baldini, E, Conti, L, De Virgilio, A, Ferreli, F, Gaino, F, Mercante, G, Spriano, G, Ansarin, M, Chu, F, De Berardinis, R, Ietrobon, G, Tagliabue, M, Ionna, F, Baietti, A, Maremonti, P, Neri, F, Prucher, G, Ricci, S, Casaril, A, Nama, M, Cotoia, A, Lizzi, V, Vovola, F, Bruzzaniti, P, Familiari, P, Lapolla, P, Marruzzo, G, Mingoli, A, Ribuffo, D, Cipriani, R, Contedini, F, Lauretta, M, Marchetti, C, Melotti, M, Pignatti, M, Pinto, V, Pizzigallo, A, Ricotta, F, Tarsitano, A, Catarzi, L, Consorti, G, Abdulwahed, EA, Alshareea, EA, Biala, MI, Ghmagh, RJ, Ibrahim, AF, Liew, YT, Alvarez, MR, Arrangoiz, R, Cordera, F, Gómez-Pedraza, A, Soulé-Martínez, CE, Becerril, OS, Becerra, GFC, Arkha, Y, Bechri, H, El Ouahabi, A, Oudrhiri, M, Benkabbou, A, Majbar, M, Mohsine, R, Souadka, A, Lageju, N, Schreuder, WH, Hardillo, J, Bree, R, Schweitzer, D, Adeyeye, AA, Enoch, EE, Sholadoye, TSTT, Wuraola, F, Oyelakin, O, Khokhar, MI, Ayub, B, Walędziak, M, Szewczyk, M, Faria, C, Cardoso, P, Castro Silva, J, AlKharashi, E, Jelovac, D, Petrovic, M, Sumrak, S, Asceric, RR, Bojicic, JM, Kovacevic, BM, Krdzic, ID, Milentijevic, MA, Milutinovic, VZ, Stefanovic, ZB, Villacampa, JM, Jiménez Carneros, V, Salazar Carrasco, A, Carabias Hernandez, A, Alonso Lamberti, L, León Ledesma, R, Jiménez Miramón, FJ, Jover Navalón, JM, Garcia Quijada, J, Ramos Rodriguez, J, Valle Rubio, A, Vilaseca, I, Escartin, J, Estaire-Gomez, M, Padilla Valverde, D, Tousidonis, M, Lopez, F, Deandrés-Olabarria, U, Durán-Ballesteros, M, Fernández-Pablos, F, Ibáñez-Aguirre, F, Sanz-Larrainzar, A, Ugarte-Sierra, B, Di Martino, M, Prada, J, Jariod-Ferrer, UM, Landaluce Olavarria, A, Rey-Biel, J, Díaz de Cerio, P, Sánchez Barrueco, A, Lindqvist, EK, Sund, M, Piantanida, R, Giger, R, Hool, S, Müller, SA, Stoeckli, SJ, Simon, C, Toutounji, T, Al assaf, A, Hammed, AM, Hammed, SM, Mahfoud, M, Arikan, A, Yalkin, Ö, İflazoğlu, N, Isik, A, Leventoglu, S, Aydemir, L, Basaran, B, Sen, C, Comert-Ulusan, M, Saracoglu, KT, Saracoglu, A, Mantoglu, B, Kucuk, G, Aygun, N, Baran, E, Tanal, M, Eray Tufan, A, Uludag, M, Gürkan Yetkin, S, Yigit, B, Calik, B, Demirli Atici, S, Kaya, T, Sikakulya, FK, Abdel-Galil, KMAH, Lowe, T, Durrani, AJ, Habeeb, A, Irune, E, Luke, L, Masterson, L, Murphy, SH, Segaren, N, Walker, C, Waseem, S, Jones, TM, Loh, C, Pringle, S, Schache, AG, Shaw, RJ, Stenhouse, J, Armstrong, M, Sood, S, Sutton, D, Thomas, S, Clarke, P, Winter, SC, Hislop, S, Counter, PR, Ghazali, N, Lloyd, C, Prabhu, V, Godden, D, Whitley, S, Butler, C, Nash, R, El-Boghdadly, K, Fry, A, Niziol, R, De, M, Gill, CK, Crank, S, Mace, AD, Ho, M, Mair, M, Kothari, P, Homer, J, Sainuddin, S, Egan, RJ, Kittur, M, Burgess, C, O'Hara, J, Manickavasagam, J, McDonald, C, Burrows, S, Java, KR, Katre, C, Ahmed, A, Siddique, H, King, E, Ramchandani, P, Naredla, PR, Brennan, P, Ringrose, T, Schmidt, F, Mak, JKC, Nankivell, P, Parmar, S, Sharma, N, Douglas, C, McCaul, J, Dhanda, J, Kyzas, P, Vassiliou, L, Kumar, A, Husband, A, Hulbert, J, Ingrams, D, Parkin, R, Varley, I, Gahir, D, George, A, Zakai, D, Bater, M, Surwald, C, Devlin, B, Leonard, CG, Pigadas, N, Snee, D, Singh, RP, Hyde, NC, Paley, M, Cocks, H, Wilson, A, Choi, D, Kerawala, CJ, Riva, F, Dickason, A, Semple, CJ, Schilling, C, Walton, G, Rees-Stoner, O, Scott, N, Nixon, IJ, Tighe, D, Mattine, S, Chu, MMH, Pothula, V, Lee, W, Brown, L, Ganly, I, Alpert, N, Illezeau, CN, Miles, B, Rapp, J, Taioli, E, Azam, MT, Choudhry, AJ, Marx, W, Stein, J, Ying, Y, Gross, ND, Almasri, M, Joshi, R, Kulkarni, G, Marwan, H, Mehdi, M, Sumer, B, Collaborative, COVIDSurg, and Winter, SC
Subjects: medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), delay, medicine.medical_treatment, Comorbidity, SARS‐CoV‐2, surgery, Tertiary Care Centers, Patient referral, COVID‐19, Pandemic, medicine, Humans, Current wave, Pandemics, SARS-CoV-2, business.industry, capacity, pandemic, General surgery, Head and neck cancer, COVID-19, Original Articles, medicine.disease, United Kingdom, Otorhinolaryngologic Surgical Procedures, critical care, Radiation therapy, head and neck cancer, comorbidity, head and neck neoplasms, humans, otorhinolaryngologic surgical procedures, tertiary care centers, Otorhinolaryngology, Head and Neck Neoplasms, Original Article, business, Cancer surgery
Abstract: Objectives: The aim of this study was to evaluate the differences in surgical capacity for head and neck cancer in the UK between the first wave (March‐June 2020) and the current wave (Jan‐Feb 2021) of the COVID‐19 pandemic. Design: REDcap online based survey of hospital capacity. Setting: UK secondary and tertiary hospitals providing head and neck cancer surgery. Participants: One representative per hospital was asked to report the capacity for head and neck cancer surgery in that institution. Main Outcome Measures: The principal measures of interests were new patient referrals, capacity in outpatients, theatres and critical care; therapeutic compromises constituting delay to surgery, de‐escalated surgery and therapeutic migration to non‐surgical primary modality. Results: Data was returned from approximately 95% of UK hospitals with a head and neck cancer surgery specialist service. 50% of UK head and neck cancer patients requiring surgery have significantly compromised treatments during the second wave: 28% delayed, 10% have received radiotherapy‐based treatment instead of surgery and 12% have received de‐escalated surgery. Surgical capacity has been more severely constrained in the second wave (58% of pre‐pandemic level) compared with the first wave (62%) despite the time to prepare. Conclusions: Some hospitals are overwhelmed by COVID‐19 and unable to offer essential cancer surgery, but all have neighbouring hospitals in their region retaining good (or even normal) capacity. It is noteworthy that very few patients have been appropriately re‐directed away from the hospitals most constrained by their burden of COVID‐19. The paucity of an effective central or regional strategic response to this evident mismatch between demand and surgical capacity is to the detriment of our head and neck cancer patients.
Published: 2021

5. The root and development of otorhinolaryngology in traditional Chinese medicine

Author: Yap, L., Pothula, V. B., Warner, J., Akhtar, S., and Yates, E.
Published: 2009
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6. Microvascular decompression of cochleovestibular nerve

Author: Yap, L., Pothula, V. B., and Lesser, T.
Published: 2008
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7. Introduction of a new surgical technique: minimally invasive video-assisted thyroid surgery

Author: Mamais, C., Charaklias, N., Pothula, V. B., Dias, A., Hawthorne, M., and Nirmal Kumar, B.
Published: 2011
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8. THE ROOT AND DEVELOPMENT OF OTOLARYNGOLOGY IN TRADITIONAL CHINESE MEDICINE: SH01

Author: Yap, L. and Pothula, V. B.
Published: 2008

9. Care of Battlefield Injuries

Author: Pothula, V. and Gupta, Sanjay.
Published: 2004
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10. Falls and vestibular impairment

Author: POTHULA, V. B., CHEW, F., LESSER, T. H.J., and SHARMA, A. K.
Published: 2004

11. Metastatic melanoma of gastrocolic ligament treated with minimally invasive approach

Author: Sreenivas, V. I., Damen, M., Agarwal, S., and Pothula, V.
Published: 1997
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12. MEF2C transcription factor is associated with the genetic and epigenetic risk architecture of schizophrenia and improves cognition in mice

Author: Mitchell, A C, primary, Javidfar, B, additional, Pothula, V, additional, Ibi, D, additional, Shen, E Y, additional, Peter, C J, additional, Bicks, L K, additional, Fehr, T, additional, Jiang, Y, additional, Brennand, K J, additional, Neve, R L, additional, Gonzalez-Maeso, J, additional, and Akbarian, S, additional
Published: 2017
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13. Neuronal Kmt2a/Mll1 Histone Methyltransferase Is Essential for Prefrontal Synaptic Plasticity and Working Memory

Author: Jakovcevski, M., primary, Ruan, H., additional, Shen, E. Y., additional, Dincer, A., additional, Javidfar, B., additional, Ma, Q., additional, Peter, C. J., additional, Cheung, I., additional, Mitchell, A. C., additional, Jiang, Y., additional, Lin, C. L., additional, Pothula, V., additional, Stewart, A. F., additional, Ernst, P., additional, Yao, W.-D., additional, and Akbarian, S., additional
Published: 2015
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14. Giant tonsillolith - a rare cause of dysphagia

Author: Dykes, M., primary, Izzat, S., additional, and Pothula, V., additional
Published: 2012
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15. Atrial lead placement at the lower atrial septum: a potential strategy to reduce unnecessary right ventricular pacing

Author: Acosta, H., primary, Viafara, L. M., additional, Izquierdo, D., additional, Pothula, V. R., additional, Bear, J., additional, Pothula, S., additional, Antonio-Drabeck, C., additional, and Lee, K., additional
Published: 2012
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16. Otology in ancient India

Author: Pothula, V. B., primary, Jones, T. M., additional, and Lesser, T. H. J., additional
Published: 2001
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17. Verrucous squamous carcinoma of the nasal septum

Author: Pothula, V. B., primary and Jones, H. Savage, additional
Published: 1998
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18. Splenic syndrome: a rare indication for splenectomy.

Author: Pothula V, Saegusa E, Takekoshi D, Edson T, Ignacio R, Pothula, Viswanadham, Saegusa, Emi, Takekoshi, Daisuke, Edson, Theodore, and Ignacio, Romeo
Abstract: Splenic infarction due to sickle cell trait and high-altitude stress has been reported in the literature. Contributing factors leading to infarction are degree of altitude stress and status of physical condition. Medical therapy, which consists of evacuation from high altitude, intravenous fluids, supplemental oxygen, and pain control, has been the mainstay of treatment. However, some patients require surgical intervention. We describe six patients with sickle cell trait who sustained splenic infarctions due to high-altitude stress; two of these patients required splenectomy for near-total splenic necrosis and intractable pain. A review of the literature demonstrates that the common indications for splenectomy are splenic rupture, extensive splenic necrosis, or persistent abdominal pain. [ABSTRACT FROM AUTHOR]
Published: 2008
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19. Vestibular schwannomas in children.

Author: Pothula, Vijay B., Lesser, Tristram, Mallucci, Conor, May, Paul, Foy, P., Pothula, V B, Lesser, T, Mallucci, C, and May, P
Published: 2001
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20. Laryngopharyngeal reflux and primary snoring: a pilot case-control study

Author: Charaklias N, Constantinos Mamais, Pothula V, and Bn, Kumar
Subjects: Adult, Male, Case-Control Studies, Snoring, Laryngopharyngeal Reflux, Humans, Female, Pilot Projects, Comorbidity, Middle Aged, Aged
Abstract: Laryngopharyngeal reflux has been implicated as a causative factor in the aetiology of sleep related breathing disorders. However there are no reports on the association of this disorder and primary snoring in the absence of obstructive sleep apnoea. This study was undertaken to investigate any link between primary snoring and the presence of laryngopharyngeal reflux.A matched case-control study was performed in a district general Ear Nose Throat outpatient population in the United Kingdom. Twenty six patients referred for snoring without sleep apnoea (cases) were individually matched for gender, body mass index and age, to 26 patients referred for other otorhinolaryngological complaints (controls). Snoring was not an exclusion criterion for the controls. Exclusion criteria for both groups were previous referral or treatment for snoring and/or sleep apnoea, nasal obstruction symptoms (as a potential cause of snoring), and known history of gastrooesophageal reflux with medical treatment longer than two months. The main outcome measure was prevalence of laryngopharyngeal reflux based on the Reflux Symptom Index score.Patients seeking medical advice for primary snoring are fourteen times more likely to report Reflux Symptom Index scores of more than 13 than controls.Laryngopharyngeal reflux may also be implicated in the pathogenesis of primary snoring in the absence of sleep apnoea. This constitutes 3b level of evidence.

21. Endovascular Repair of Anastomotic Site Pseudoaneurysms in a Transplant Renal Artery Using Flow-Diverter Stents.

Author: Pothula V, Ray N, Dhanasekaran J, Sekar S, and Joseph S
Subjects: Humans, Renal Artery diagnostic imaging, Renal Artery surgery, Stents, Treatment Outcome, Retrospective Studies, Aneurysm, False diagnostic imaging, Aneurysm, False etiology, Aneurysm, False surgery, Kidney Transplantation adverse effects, Endovascular Procedures, Intracranial Aneurysm
Published: 2023
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22. Differential effects of the second SARS-CoV-2 mRNA vaccine dose on T cell immunity in naive and COVID-19 recovered individuals.

Author: Lozano-Ojalvo D, Camara C, Lopez-Granados E, Nozal P, Del Pino-Molina L, Bravo-Gallego LY, Paz-Artal E, Pion M, Correa-Rocha R, Ortiz A, Lopez-Hoyos M, Iribarren ME, Portoles J, Rojo-Portoles MP, Ojeda G, Cervera I, Gonzalez-Perez M, Bodega-Mayor I, Montes-Casado M, Portoles P, Perez-Olmeda M, Oteo J, Sanchez-Tarjuelo R, Pothula V, Schwarz M, Brahmachary M, Tan AT, Le Bert N, Berin C, Bertoletti A, Guccione E, and Ochando J
Subjects: Antibodies, Viral blood, CD40 Ligand metabolism, COVID-19 immunology, COVID-19 pathology, COVID-19 virology, COVID-19 Vaccines administration & dosage, COVID-19 Vaccines chemistry, COVID-19 Vaccines immunology, Humans, Immunity, Cellular, Immunity, Humoral, Immunoglobulin G blood, Interferon-gamma metabolism, Interleukin-2 metabolism, Peptides immunology, SARS-CoV-2 isolation & purification, SARS-CoV-2 metabolism, Spike Glycoprotein, Coronavirus immunology, T-Lymphocytes cytology, T-Lymphocytes metabolism, Vaccination, Vaccines, Synthetic immunology, mRNA Vaccines, COVID-19 prevention & control, T-Lymphocytes immunology, Vaccines, Synthetic administration & dosage
Abstract: The rapid development of mRNA-based vaccines against the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) led to the design of accelerated vaccination schedules that have been extremely effective in naive individuals. While a two-dose immunization regimen with the BNT162b2 vaccine has been demonstrated to provide a 95% efficacy in naive individuals, the effects of the second vaccine dose in individuals who have previously recovered from natural SARS-CoV-2 infection has not been investigated in detail. In this study, we characterize SARS-CoV-2 spike-specific humoral and cellular immunity in naive and previously infected individuals during and after two doses of BNT162b2 vaccination. Our results demonstrate that, while the second dose increases both the humoral and cellular immunity in naive individuals, COVID-19 recovered individuals reach their peak of immunity after the first dose. These results suggests that a second dose, according to the current standard regimen of vaccination, may be not necessary in individuals previously infected with SARS-CoV-2., Competing Interests: Declaration of interests A.B. declares the filing of a patent application relating to the use of peptide pools in whole blood for detection of SARS-CoV-2 T cells (pending). The remaining authors declare no competing interests., (Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.)
Published: 2021
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23. Histone deacetylase 9 promotes endothelial-mesenchymal transition and an unfavorable atherosclerotic plaque phenotype.

Author: Lecce L, Xu Y, V'Gangula B, Chandel N, Pothula V, Caudrillier A, Santini MP, d'Escamard V, Ceholski DK, Gorski PA, Ma L, Koplev S, Bjørklund MM, Björkegren JL, Boehm M, Bentzon JF, Fuster V, Kim HW, Weintraub NL, Baker AH, Bernstein E, and Kovacic JC
Subjects: Animals, Atherosclerosis genetics, Atherosclerosis pathology, Endothelium pathology, Histone Deacetylases genetics, Human Umbilical Vein Endothelial Cells, Humans, Mice, Mice, Knockout, ApoE, Plaque, Atherosclerotic genetics, Plaque, Atherosclerotic pathology, Repressor Proteins genetics, Atherosclerosis enzymology, Endothelium enzymology, Histone Deacetylases metabolism, Plaque, Atherosclerotic enzymology, Repressor Proteins metabolism
Abstract: Endothelial-mesenchymal transition (EndMT) is associated with various cardiovascular diseases and in particular with atherosclerosis and plaque instability. However, the molecular pathways that govern EndMT are poorly defined. Specifically, the role of epigenetic factors and histone deacetylases (HDACs) in controlling EndMT and the atherosclerotic plaque phenotype remains unclear. Here, we identified histone deacetylation, specifically that mediated by HDAC9 (a class IIa HDAC), as playing an important role in both EndMT and atherosclerosis. Using in vitro models, we found class IIa HDAC inhibition sustained the expression of endothelial proteins and mitigated the increase in mesenchymal proteins, effectively blocking EndMT. Similarly, ex vivo genetic knockout of Hdac9 in endothelial cells prevented EndMT and preserved a more endothelial-like phenotype. In vivo, atherosclerosis-prone mice with endothelial-specific Hdac9 knockout showed reduced EndMT and significantly reduced plaque area. Furthermore, these mice displayed a more favorable plaque phenotype, with reduced plaque lipid content and increased fibrous cap thickness. Together, these findings indicate that HDAC9 contributes to vascular pathology by promoting EndMT. Our study provides evidence for a pathological link among EndMT, HDAC9, and atherosclerosis and suggests that targeting of HDAC9 may be beneficial for plaque stabilization or slowing the progression of atherosclerotic disease.
Published: 2021
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24. Use of office based transnasal oesophagoscopy in management of Head & Neck conditions during the COVID-19 pandemic at the Royal Albert Edward Infirmary, Wigan, United Kingdom.

Author: Goyal M, McNally G, Batra A, Izzat S, and Pothula V
Subjects: Esophagoscopy, Hospitals, Humans, SARS-CoV-2, United Kingdom epidemiology, COVID-19, Pandemics
Abstract: Objectives: To assess the clinical and cost effectiveness of transnasal oesophagoscopy (TNO) in cases of suspected upper aerodigestive tract malignancy and define its role as a safe alternative to panendoscopy. We have also analysed if the implementation of TNO during the COVID-19 pandemic was beneficial in order to provide uninterrupted care to the patients with the limited resources available in these challenging times., Methods: All patients who underwent TNO guided biopsies or dilatation attempted over a 7 month period during COVID- 19 pandemic were included by searching the hospital and department database at The Royal Albert Edward Infirmary. A comparative group of patients who underwent panendoscopy over 9 months were included for comparison. Demographic data, histological diagnosis, second procedure and cost involved were recorded., Results: During this period, 20 TNO procedures (16 biopsies and 4 dilatations) were attempted which were compared with 20 panendoscopy procedures. The diagnostic accuracy of TNO biopsy for identifying benign and malignant pathology was 81.1%. The sensitivity and specificity for identifying malignancy was 76.9% and 100% respectively. The most common lesion location was laryngeal (43.8%) followed by oropharyngeal (37.5%), more specifically located at the tongue base. The median waiting period between the procedure being listed and TNO being performed was 5.5 days compared to 12 days for panendoscopy. There were 12/16 patients who did not require further interventions for histological diagnosis of the tumor. The TNO procedure was well tolerated with no complications and all were done under local anaesthesia as outpatient procedure without need for admission. TNO resulted in cost saving of £356 per case on a standard NHS tariff., Conclusion: TNO is a valuable diagnostic tool for patients with suspected UADT malignancy and dysphagia and has proven to be an asset during the COVID-19 pandemic when we have to make the best use of the limited theatre time and resources. Also, the cost analysis showed that outpatient based TNO can provide significant cost savings for the current standard of care. Furthermore, it has shown better patient tolerability, lesser complications and shortened the time for diagnosis and hence starting timely treatment for these patients.
Published: 2021

25. Parameningeal alveolar rhabdomyosarcoma in a child.

Author: Kumar A and Pothula V
Subjects: Adolescent, Child, Family, Humans, Male, Neoplasm Recurrence, Local, Head and Neck Neoplasms, Meningeal Neoplasms, Rhabdomyosarcoma, Rhabdomyosarcoma, Alveolar diagnostic imaging, Rhabdomyosarcoma, Alveolar therapy, Rhabdomyosarcoma, Embryonal
Abstract: This is the case of a parameningeal alveolar rhabdomyosarcoma (ARMS) in a 13-year-old boy who presented with painless loss of vision in the right eye, but very few other physical signs. The ARMS diagnosis was confirmed with imaging and molecular characterisation of the tumour. Despite tolerating the initial chemotherapy and radiotherapy regimens, there was leptomeningeal recurrence and the patient unfortunately passed away. Parameningeal ARMS occurs in an area of the body, which leads to a wide variety of possible presenting symptoms, creating a long list of differentials that can delay treatment. This tumour subtype has a poor prognosis, and due to the location of the tumour around vital structures in the head, treatment toxicities must be taken into account. This highlights the necessity for having a strong index of suspicion for this tumour in atypical presentations in children, and the necessity for prompt treatment to prevent leptomeningeal disease from occurring., Competing Interests: Competing interests: None declared., (© BMJ Publishing Group Limited 2021. No commercial re-use. See rights and permissions. Published by BMJ.)
Published: 2021
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26. Primary squamous cell carcinoma of the thyroid gland successfully treated with surgical resection and adjuvant chemoradiotherapy.

Author: Chu MMH, Mirza O, Bishop PW, and Pothula V
Subjects: Chemoradiotherapy, Adjuvant, Female, Humans, Middle Aged, Neck Dissection, Radiotherapy, Adjuvant, Thyroid Gland, Thyroidectomy, Carcinoma, Squamous Cell surgery, Thyroid Neoplasms surgery
Abstract: A 57-year-old woman presented with a 3-month history of an enlarging thyroid mass causing breathlessness and dysphagia. Cross-sectional imaging showed a thyroid tumour infiltrating the trachea and abutting the oesophagus. She underwent panendoscopy, total thyroidectomy and planned tracheal resection, but due to intraoperative findings, a staged procedure was planned instead. Histological analysis revealed a poorly differentiated squamous cell carcinoma (SCC) which was positive on paired box gene 8 (PAX8) immunostaining, suggesting a diagnosis of primary thyroid SCC. She subsequently underwent total laryngectomy and bilateral neck dissections followed by radiotherapy with concurrent cisplatin chemotherapy. The patient remains disease-free 22 months after treatment. Median overall survival is 10 months for macroscopically completely resected tumours. PAX8 immunostaining is a novel technique which helps with the diagnostic challenge of distinguishing between primary thyroid SCC and SCC metastatic to the thyroid from extrathyroidal sites. Complete surgical resection with adjuvant chemoradiotherapy may result in a favourable outcome despite conflicting reports in the literature., Competing Interests: Competing interests: None declared., (© BMJ Publishing Group Limited 2021. No commercial re-use. See rights and permissions. Published by BMJ.)
Published: 2021
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27. Macrophages in Organ Transplantation.

Author: Ordikhani F, Pothula V, Sanchez-Tarjuelo R, Jordan S, and Ochando J
Subjects: Allografts immunology, Animals, Graft Survival, Humans, Immunologic Memory, Immunomodulation, Transplantation Tolerance, Graft Rejection immunology, Macrophages immunology, Organ Transplantation
Abstract: Current immunosuppressive therapy has led to excellent short-term survival rates in organ transplantation. However, long-term graft survival rates are suboptimal, and a vast number of allografts are gradually lost in the clinic. An increasing number of animal and clinical studies have demonstrated that monocytes and macrophages play a pivotal role in graft rejection, as these mononuclear phagocytic cells recognize alloantigens and trigger an inflammatory cascade that activate the adaptive immune response. Moreover, recent studies suggest that monocytes acquire a feature of memory recall response that is associated with a potent immune response. This form of memory is called "trained immunity," and it is retained by mechanisms of epigenetic and metabolic changes in innate immune cells after exposure to particular ligands, which have a direct impact in allograft rejection. In this review article, we highlight the role of monocytes and macrophages in organ transplantation and summarize therapeutic approaches to promote tolerance through manipulation of monocytes and macrophages. These strategies may open new therapeutic opportunities to increase long-term transplant survival rates in the clinic., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2020 Ordikhani, Pothula, Sanchez-Tarjuelo, Jordan and Ochando.)
Published: 2020
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28. Polycomb Repressive Complex 1 Controls Maintenance of Fungiform Papillae by Repressing Sonic Hedgehog Expression.

Author: Bar C, Cohen I, Zhao D, Pothula V, Litskevitch A, Koseki H, Zheng D, and Ezhkova E
Subjects: Animals, Body Patterning genetics, Cell Cycle genetics, Chromatin Immunoprecipitation, Chromatin Immunoprecipitation Sequencing, Cyclin-Dependent Kinase Inhibitor p16 genetics, Cyclin-Dependent Kinase Inhibitor p16 metabolism, Epigenesis, Genetic, Epithelium metabolism, Epithelium ultrastructure, Gene Expression Regulation, Developmental genetics, Gene Ontology, Hedgehog Proteins genetics, Mice, Mice, Knockout, Microscopy, Electron, Scanning, Polycomb Repressive Complex 1 genetics, Polycomb Repressive Complex 2 genetics, Polycomb Repressive Complex 2 metabolism, RNA-Seq, Signal Transduction genetics, Taste Buds growth & development, Taste Buds ultrastructure, Tongue growth & development, Tongue physiology, Hedgehog Proteins metabolism, Polycomb Repressive Complex 1 metabolism, Taste Buds metabolism, Tongue metabolism
Abstract: How tissue patterns are formed and maintained are fundamental questions. The murine tongue epithelium, a paradigm for tissue patterning, consists of an array of specialized fungiform papillae structures that harbor taste cells. The formation of fungiform papillae is preceded by pronounced spatial changes in gene expression, in which taste cell genes such as Shh, initially diffused in lingual epithelial progenitors, become restricted to taste cells when their specification progresses. However, the requirement of spatial restriction of taste cell gene expression for patterning and formation of fungiform papillae is unknown. Here, we show that a chromatin regulator, Polycomb repressive complex (PRC) 1, is required for proper maintenance of fungiform papillae by repressing Shh and preventing ectopic SHH signaling in non-taste cells. Ablation of SHH signaling in PRC1-null non-taste cells rescues the maintenance of taste cells. Altogether, our studies exemplify how epigenetic regulation establishes spatial gene expression patterns necessary for specialized niche structures., (Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.)
Published: 2019
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29. Dissection of Merkel cell formation in hairy and glabrous skin reveals a common requirement for FGFR2-mediated signalling.

Author: Nguyen MB, Valdes VJ, Cohen I, Pothula V, Zhao D, Zheng D, and Ezhkova E
Subjects: Animals, Female, Mice, Pregnancy, Skin cytology, Transcriptome, Merkel Cells, Receptor, Fibroblast Growth Factor, Type 2 metabolism, Skin embryology
Abstract: Merkel cells are mechanosensory cells involved in tactile discrimination. Merkel cells have been primarily studied in the murine back skin, where they are found in specialized structures called touch domes located around primary hair follicles. Yet, little is known about the morphogenesis of Merkel cells in areas of the skin devoid of hair, such as the glabrous paw skin. Here, we describe Merkel cell formation in the glabrous paw skin during embryogenesis. We first found in the glabrous paw skin that Merkel cells were specified at E15.5, 24 hours later, compared to in the back skin. Additionally, by performing lineage-tracing experiments, we found that unlike in the back skin, SOX9(+) cells do not give rise to Merkel cells in the glabrous paw skin. Finally, we compared the transcriptomes of Merkel cells in the back and the glabrous paw skin and showed that they are similar. Genetic and transcriptome studies showed that the formation of Merkel cells in both regions was controlled by similar regulators. Among them was FGFR2, an upstream factor of MAPK signalling that was reported to have a critical function in Merkel cell formation in the back skin. Here, we showed that FGFR2 is also required for Merkel cell development in the glabrous paw skin. Taken together, our results demonstrate that Merkel cells in the murine back skin and glabrous paw skin are similar, and even though their formation is controlled by a common genetic programme, their precursor cells might differ., (© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Published: 2019
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30. Neutrophil derived CSF1 induces macrophage polarization and promotes transplantation tolerance.

Author: Braza MS, Conde P, Garcia M, Cortegano I, Brahmachary M, Pothula V, Fay F, Boros P, Werner SA, Ginhoux F, Mulder WJM, and Ochando J
Subjects: Animals, Cell Differentiation, Cell Proliferation, Female, Humans, Macrophages cytology, Male, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Neutrophils metabolism, Signal Transduction, Heart Transplantation, Immune Tolerance immunology, Macrophage Colony-Stimulating Factor metabolism, Macrophages immunology, Neutrophils immunology, Transplantation Tolerance immunology
Abstract: The colony-stimulating factor 1 (CSF1) regulates the differentiation and function of tissue macrophages and determines the outcome of the immune response. The molecular mechanisms behind CSF1-mediated macrophage development remain to be elucidated. Here we demonstrate that neutrophil-derived CSF1 controls macrophage polarization and proliferation, which is necessary for the induction of tolerance. Inhibiting neutrophil production of CSF1 or preventing macrophage proliferation, using targeted nanoparticles loaded with the cell cycle inhibitor simvastatin, abrogates the induction of tolerance. These results provide new mechanistic insights into the developmental requirements of tolerogenic macrophages and identify CSF1 producing neutrophils as critical regulators of the immunological response., (© 2018 The Authors. American Journal of Transplantation published by Wiley Periodicals, Inc. on behalf of The American Society of Transplantation and the American Society of Transplant Surgeons.)
Published: 2018
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31. Barriers to timely diagnosis and treatment for children with hearing impairment in a southern Indian city: a qualitative study of parents and clinic staff.

Author: Merugumala SV, Pothula V, and Cooper M
Subjects: Adult, Auditory Perception, Child, Child, Preschool, Cultural Characteristics, Disabled Children psychology, Female, Health Knowledge, Attitudes, Practice, Health Services Accessibility organization & administration, Hearing, Hearing Disorders physiopathology, Hearing Disorders psychology, Humans, India, Infant, Interviews as Topic, Male, Persons With Hearing Impairments psychology, Qualitative Research, Socioeconomic Factors, Time Factors, Treatment Outcome, Young Adult, Attitude of Health Personnel, Delivery of Health Care, Integrated organization & administration, Disabled Children rehabilitation, Hearing Disorders diagnosis, Hearing Disorders therapy, Mothers psychology, Persons With Hearing Impairments rehabilitation, Process Assessment, Health Care organization & administration, Time-to-Treatment organization & administration, Urban Health Services organization & administration
Abstract: Objective: In low income countries, deaf children are identified late due to the absence of a universal screening. Hearing impairment is a common yet neglected disability in India that leads to loss of speech and language. This qualitative study explored barriers to accessing appropriate hearing services in one city in southern India., Design: To identify the barriers in timely management of deafness, 25 semi-structured interviews were conducted. Data were examined using Applied Thematic Analysis., Study Sample: Seventeen mothers of deaf children, primarily from low socioeconomic backgrounds, and eight staff members at a charitable hearing centre in Hyderabad., Results: Barriers to accessing hearing services included failure to recognise deafness, the dominant role of elders in household decisions, belief that deafness would resolve, reassurance from a child's overall good health, lack of funds and transportation barriers to reach the centre particularly from rural areas. Parents frequently learned about services through word of mouth., Conclusions: The challenges to accessing appropriate services for deafness operate prior to presentation and include educational, cultural, navigational and financial barriers especially for those of lower socioeconomic status and residents of rural areas. The findings highlighted the need to raise awareness and implement wider screening programmes for early interventions.
Published: 2017
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32. CXCR4 and CXCR7 play distinct roles in cardiac lineage specification and pharmacologic β-adrenergic response.

Author: Ceholski DK, Turnbull IC, Pothula V, Lecce L, Jarrah AA, Kho C, Lee A, Hadri L, Costa KD, Hajjar RJ, and Tarzami ST
Subjects: Biomarkers metabolism, Calcium metabolism, Cardiomegaly pathology, Gene Expression Regulation, Gene Knockdown Techniques, HEK293 Cells, Humans, Induced Pluripotent Stem Cells metabolism, Lentivirus metabolism, Myocytes, Cardiac metabolism, Organogenesis, RNA, Small Interfering metabolism, Cell Lineage, Myocardium cytology, Myocardium metabolism, Receptors, Adrenergic, beta metabolism, Receptors, CXCR metabolism, Receptors, CXCR4 metabolism
Abstract: CXCR4 and CXCR7 are prominent G protein-coupled receptors (GPCRs) for chemokine stromal cell-derived factor-1 (SDF-1/CXCL12). This study demonstrates that CXCR4 and CXCR7 induce differential effects during cardiac lineage differentiation and β-adrenergic response in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). Using lentiviral vectors to ablate CXCR4 and/or CXCR7 expression, hiPSC-CMs were tested for phenotypic and functional properties due to gene knockdown. Gene expression and flow cytometry confirmed the pluripotent and cardiomyocyte phenotype of undifferentiated and differentiated hiPSCs, respectively. Although reduction of CXCR4 and CXCR7 expression resulted in a delayed cardiac phenotype, only knockdown of CXCR4 delayed the spontaneous beating of hiPSC-CMs. Knockdown of CXCR4 and CXCR7 differentially altered calcium transients and β-adrenergic response in hiPSC-CMs. In engineered cardiac tissues, depletion of CXCR4 or CXCR7 had opposing effects on developed force and chronotropic response to β-agonists. This work demonstrates distinct roles for the SDF-1/CXCR4 or CXCR7 network in hiPSC-derived ventricular cardiomyocyte specification, maturation and function., (Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.)
Published: 2017
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33. Practical Guidelines for High-Resolution Epigenomic Profiling of Nucleosomal Histones in Postmortem Human Brain Tissue.

Author: Kundakovic M, Jiang Y, Kavanagh DH, Dincer A, Brown L, Pothula V, Zharovsky E, Park R, Jacobov R, Magro I, Kassim B, Wiseman J, Dang K, Sieberts SK, Roussos P, Fromer M, Harris B, Lipska BK, Peters MA, Sklar P, and Akbarian S
Subjects: Acetylation, Antigens, Nuclear metabolism, Chromatin Immunoprecipitation, Humans, Methylation, Nerve Tissue Proteins metabolism, Neurons metabolism, Protein Processing, Post-Translational, Cerebral Cortex metabolism, Epigenesis, Genetic, Epigenomics methods, High-Throughput Nucleotide Sequencing methods, Histones metabolism, Nucleosomes metabolism
Abstract: Background: The nervous system may include more than 100 residue-specific posttranslational modifications of histones forming the nucleosome core that are often regulated in cell-type-specific manner. On a genome-wide scale, some of the histone posttranslational modification landscapes show significant overlap with the genetic risk architecture for several psychiatric disorders, fueling PsychENCODE and other large-scale efforts to comprehensively map neuronal and nonneuronal epigenomes in hundreds of specimens. However, practical guidelines for efficient generation of histone chromatin immunoprecipitation followed by deep sequencing (ChIP-seq) datasets from postmortem brains are needed., Methods: Protocols and quality controls are given for the following: 1) extraction, purification, and NeuN neuronal marker immunotagging of nuclei from adult human cerebral cortex; 2) fluorescence-activated nuclei sorting; 3) preparation of chromatin by micrococcal nuclease digest; 4) ChIP for open chromatin-associated histone methylation and acetylation; and 5) generation and sequencing of ChIP-seq libraries., Results: We present a ChIP-seq pipeline for epigenome mapping in the neuronal and nonneuronal nuclei from the postmortem brain. This includes a stepwise system of quality controls and user-friendly data presentation platforms., Conclusions: Our practical guidelines will be useful for projects aimed at histone posttranslational modification mapping in chromatin extracted from hundreds of postmortem brain samples in cell-type-specific manner., Competing Interests: The authors report no biomedical financial interests or potential conflicts of interest., (Copyright © 2016 Society of Biological Psychiatry. All rights reserved.)
Published: 2017
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34. Neuronal Deletion of Kmt2a/Mll1 Histone Methyltransferase in Ventral Striatum is Associated with Defective Spike-Timing-Dependent Striatal Synaptic Plasticity, Altered Response to Dopaminergic Drugs, and Increased Anxiety.

Author: Shen EY, Jiang Y, Javidfar B, Kassim B, Loh YE, Ma Q, Mitchell AC, Pothula V, Stewart AF, Ernst P, Yao WD, Martin G, Shen L, Jakovcevski M, and Akbarian S
Subjects: Action Potentials drug effects, Animals, Animals, Newborn, Circadian Rhythm drug effects, Circadian Rhythm genetics, Disease Models, Animal, Female, Histone-Lysine N-Methyltransferase genetics, Locomotion drug effects, Locomotion genetics, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Myeloid-Lymphoid Leukemia Protein genetics, Nerve Tissue Proteins metabolism, Neurons drug effects, Oligonucleotide Array Sequence Analysis, Signal Transduction drug effects, Signal Transduction genetics, Action Potentials genetics, Anxiety drug therapy, Anxiety genetics, Anxiety metabolism, Anxiety physiopathology, Dopamine Agents pharmacology, Histone-Lysine N-Methyltransferase deficiency, Myeloid-Lymphoid Leukemia Protein deficiency, Neuronal Plasticity genetics, Neurons physiology, Ventral Striatum cytology
Abstract: Lysine (K) methyltransferase 2a (Kmt2a) and other regulators of H3 lysine 4 methylation, a histone modification enriched at promoters and enhancers, are widely expressed throughout the brain, but molecular and cellular phenotypes in subcortical areas remain poorly explored. We report that Kmt2a conditional deletion in postnatal forebrain is associated with excessive nocturnal activity and with absent or blunted responses to stimulant and dopaminergic agonist drugs, in conjunction with near-complete loss of spike-timing-dependent long-term potentiation in medium spiny neurons (MSNs). Selective ablation of Kmt2a, but not the ortholog Kmt2b, in adult ventral striatum/nucleus accumbens neurons markedly increased anxiety scores in multiple behavioral paradigms. Striatal transcriptome sequencing in adult mutants identified 262 Kmt2a-sensitive genes, mostly downregulated in Kmt2a-deficient mice. Transcriptional repression includes the 5-Htr2a serotonin receptor, strongly associated with anxiety- and depression-related disorders in human and animal models. Consistent with the role of Kmt2a in promoting gene expression, the transcriptional regulators Bahcc1, Isl1, and Sp9 were downregulated and affected by H3K4 promoter hypomethylation. Therefore, Kmt2a regulates synaptic plasticity in striatal neurons and provides an epigenetic drug target for anxiety and dopamine-mediated behaviors.
Published: 2016
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35. Conserved higher-order chromatin regulates NMDA receptor gene expression and cognition.

Author: Bharadwaj R, Peter CJ, Jiang Y, Roussos P, Vogel-Ciernia A, Shen EY, Mitchell AC, Mao W, Whittle C, Dincer A, Jakovcevski M, Pothula V, Rasmussen TP, Giakoumaki SG, Bitsios P, Sherif A, Gardner PD, Ernst P, Ghose S, Sklar P, Haroutunian V, Tamminga C, Myers RH, Futai K, Wood MA, and Akbarian S
Subjects: Aged, Aged, 80 and over, Animals, Animals, Newborn, Antipsychotic Agents pharmacology, Antipsychotic Agents therapeutic use, Cells, Cultured, Cerebral Cortex cytology, Cerebral Cortex ultrastructure, Chromatin drug effects, Cognition drug effects, Female, HEK293 Cells, Humans, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Middle Aged, Neurons metabolism, Neurons ultrastructure, Polymorphism, Single Nucleotide genetics, Receptors, N-Methyl-D-Aspartate chemistry, Receptors, N-Methyl-D-Aspartate genetics, Schizophrenia drug therapy, Schizophrenia genetics, Schizophrenia pathology, Signal Transduction genetics, Transcription Factors genetics, Transcription Factors metabolism, Chromatin metabolism, Cognition physiology, Gene Expression Regulation physiology, Receptors, N-Methyl-D-Aspartate metabolism
Abstract: Three-dimensional chromosomal conformations regulate transcription by moving enhancers and regulatory elements into spatial proximity with target genes. Here we describe activity-regulated long-range loopings bypassing up to 0.5 Mb of linear genome to modulate NMDA glutamate receptor GRIN2B expression in human and mouse prefrontal cortex. Distal intronic and 3' intergenic loop formations competed with repressor elements to access promoter-proximal sequences, and facilitated expression via a "cargo" of AP-1 and NRF-1 transcription factors and TALE-based transcriptional activators. Neuronal deletion or overexpression of Kmt2a/Mll1 H3K4- and Kmt1e/Setdb1 H3K9-methyltransferase was associated with higher-order chromatin changes at distal regulatory Grin2b sequences and impairments in working memory. Genetic polymorphisms and isogenic deletions of loop-bound sequences conferred liability for cognitive performance and decreased GRIN2B expression. Dynamic regulation of chromosomal conformations emerges as a novel layer for transcriptional mechanisms impacting neuronal signaling and cognition., (Copyright © 2014 Elsevier Inc. All rights reserved.)
Published: 2014
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36. Rugulactone derivatives act as inhibitors of NF-κB activation and modulates the transcription of NF-κB dependent genes in MDA-MB-231cells.

Author: Mohapatra DK, Reddy DS, Ramaiah MJ, Ghosh S, Pothula V, Lunavath S, Thomas S, Valli SN, Bhadra MP, and Yadav JS
Subjects: Antineoplastic Agents chemical synthesis, Antineoplastic Agents pharmacology, Cell Line, Tumor, Cell Survival drug effects, Cyclin E metabolism, Cyclin-Dependent Kinase 2 metabolism, Cyclin-Dependent Kinase Inhibitor p27 genetics, Cyclin-Dependent Kinase Inhibitor p27 metabolism, G1 Phase Cell Cycle Checkpoints drug effects, Humans, Lactones chemical synthesis, Lactones pharmacology, MCF-7 Cells, NF-kappa B metabolism, Oncogene Proteins metabolism, Poly(ADP-ribose) Polymerases metabolism, Structure-Activity Relationship, Transcription, Genetic drug effects, bcl-X Protein metabolism, Antineoplastic Agents chemistry, Lactones chemistry, NF-kappa B antagonists & inhibitors
Abstract: Rugulactone and its analogues were synthesized following Horners-Wadsworth-Emmons and ring-closing metathesis as the key reactions. A library of new rugulactone analogues were designed, synthesized and evaluated for their anticancer activity in breast cancer cells. All analogues have shown anti-proliferative activity, while some of them exhibited significant cytotoxicity. In assays related to cell-cycle distribution, these conjugates induced G1 cell-cycle arrest in MDA-MB-231 cells. The cell cycle arrest nature was further confirmed by examining the effect on Cyclin E and Cdk2 proteins that acts at G1-S phase transition. Immunocytochemistry assay revealed that these compounds inhibited nuclear translocation of NF-κB protein, thereby activation of NF-κB was inhibited. The expression of NF-κB target genes such as Cyclin D1 and Bcl-xL were severely affected. Apart from acting on NF-κB, these compounds also regulate class I Histone deacetylase proteins such as (HDAC-3 and 8) that have a crucial and regulatory role in cell-proliferation. Simultaneously, the apoptotic inducing nature of these compounds was confirmed by activation of PARP protein, a protein that plays a key role in DNA damage and repair pathways. Among all compounds of this series 3g is the most potent compound and can be used for further studies., (Copyright © 2014 Elsevier Ltd. All rights reserved.)
Published: 2014
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37. Laryngopharyngeal reflux and primary snoring: a pilot case-control study.

Author: Charaklias N, Mamais C, Pothula V, and Kumar BN
Subjects: Adult, Aged, Case-Control Studies, Comorbidity, Female, Humans, Male, Middle Aged, Pilot Projects, Laryngopharyngeal Reflux epidemiology, Snoring epidemiology
Abstract: Study Objectives: Laryngopharyngeal reflux has been implicated as a causative factor in the aetiology of sleep related breathing disorders. However there are no reports on the association of this disorder and primary snoring in the absence of obstructive sleep apnoea. This study was undertaken to investigate any link between primary snoring and the presence of laryngopharyngeal reflux., Methods: A matched case-control study was performed in a district general Ear Nose Throat outpatient population in the United Kingdom. Twenty six patients referred for snoring without sleep apnoea (cases) were individually matched for gender, body mass index and age, to 26 patients referred for other otorhinolaryngological complaints (controls). Snoring was not an exclusion criterion for the controls. Exclusion criteria for both groups were previous referral or treatment for snoring and/or sleep apnoea, nasal obstruction symptoms (as a potential cause of snoring), and known history of gastrooesophageal reflux with medical treatment longer than two months. The main outcome measure was prevalence of laryngopharyngeal reflux based on the Reflux Symptom Index score., Results: Patients seeking medical advice for primary snoring are fourteen times more likely to report Reflux Symptom Index scores of more than 13 than controls., Conclusions: Laryngopharyngeal reflux may also be implicated in the pathogenesis of primary snoring in the absence of sleep apnoea. This constitutes 3b level of evidence.
Published: 2013

38. The prevalence of laryngopharyngeal reflux in the English population.

Author: Kamani T, Penney S, Mitra I, and Pothula V
Subjects: Adolescent, Adult, Body Mass Index, Comorbidity, Female, Gastroesophageal Reflux epidemiology, Humans, Irritable Bowel Syndrome epidemiology, Male, Middle Aged, Prevalence, Smoking epidemiology, United Kingdom epidemiology, Young Adult, Laryngopharyngeal Reflux epidemiology
Abstract: Although symptoms of laryngopharyngeal reflux (LPR) symptoms are commonly seen in the ENT clinic, their aetiology and prevalence in the population remain unknown. Lifestyle changes have been seen to be effective in symptom relief. We aimed to establish the prevalence of these symptoms and identify any associated factors. Pseudo-random sampling was performed on 2,000 adults that were sent a validated questionnaire containing the Reflux Symptom Index (RSI) and questions on their health and lifestyle. 45.8 % of the 378 responders were male. The mean RSI was 8.3. 30 % had an RSI of more than 10, of which 75 % had symptoms of gastro-oesophageal reflux disease (r = 0.646 at p = 0.01). Patients with depression and irritable bowel syndrome are more likely to have LPR symptoms. LPR symptoms are highly prevalent in the community and may be influenced significantly by the presence of gastro-oesophageal reflux, depression and irritable bowel syndrome.
Published: 2012
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39. The USS George Washington medical department: medicine in motion.

Author: Harwood JL and Pothula V
Subjects: General Surgery, United States, Military Medicine, Ships
Published: 2011

40. "Devil docs" in Iraq tell their story.

Author: Pothula V, Chimiak J, and Taneja A
Subjects: Humans, Iraq War, 2003-2011, Traumatology, General Surgery, Military Medicine, Military Personnel
Published: 2003

41. Videolaparoscopy in general surgery. An update.

Author: Sreenivas VI and Pothula V
Subjects: Digestive System Surgical Procedures methods, Endoscopy, Digestive System methods, Humans, Laparoscopy methods, Video-Assisted Surgery
Published: 2001

42. Carotico-cavernous fistula following septorhinoplasty.

Author: Pothula VB, Reddy KT, and Nixon TE
Subjects: Adult, Carotid Artery, Internal diagnostic imaging, Carotid-Cavernous Sinus Fistula diagnostic imaging, Carotid-Cavernous Sinus Fistula therapy, Embolization, Therapeutic, Epistaxis diagnostic imaging, Epistaxis therapy, Humans, Male, Radiography, Carotid-Cavernous Sinus Fistula etiology, Epistaxis etiology, Nasal Septum surgery, Rhinoplasty adverse effects
Abstract: Septorhinoplasty is a very common operation in otolaryngological practice. We report the second case of a carotico-cavernous fistula following septorhinoplasty. This case presented with very severe epistaxis before the appearance of the typical pulsating exophthalmos, ophthalmoplegia, headache and engorged veins on the right side of the face. Our case was treated by endovascular thrombosis with electrolytically detachable coils.
Published: 1999
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43. Laparoscopic abdominal incisional hernioplasty: principles, technique and complications.

Author: Sreenivas VI, Pothula V, Benbrahim A, and Savalgi R
Abstract: Repair of incisional herniae by direct approximation of the edges is associated with high incidence of recurrence. Tension free repair with prosthetic material was an advance in decreasing the incidence of recurrence. Repair with prosthetic material, to be successful, re qui res extensive dissection and its associated complications. Advances in laparoscopy along with the improvements in prosthetic materials has opened up opportunity for further decreasing the incidence of recurrence with minimal dissection.
Published: 1999

44. Nothing new under the sun: the management of epistaxis.

Author: Pothula V and Alderson D
Subjects: Epistaxis therapy, History, 17th Century, History, 18th Century, History, 19th Century, History, 20th Century, History, Ancient, History, Medieval, Humans, Epistaxis history
Abstract: The management of epistaxis is reviewed from ancient times onwards. Many curious methods have been employed and indeed epistaxis has been encouraged at times. Although current management is based on sound principles folklore remedies still predominate amongst some of our patients. The basis of contemporary treatments was known and practised by our ancient forbears.
Published: 1998
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45. Complications of laparoscopic inguinal hernia repair.

Author: Benbrahim A, Sreenivas VI, Pothula V, and Savalgi RS
Abstract: Laparoscopic herniorrhaphy has been gaining popularity along with other minimally invasive surgical techniques. With the sophistication of instruments, evaluation of techniques and longer follow-up of patients, the outcome of such repairs is changing. Many authors are reporting a variety of techniques, complications, and results compared to conventional surgery.
Published: 1997

46. Jaundice secondary to spilled gallstone during laparoscopic cholecystectomy.

Author: Sreenivas VI, Iyengar P, Bhagia ST, and Pothula V
Abstract: Advantages of.laparoscopiC cholecystectomy (LC) in terms of shorter hospital stay, less pain, and diminished disabilrty are well documented. Less well documented are the long-term comptications of this procedure. We report a patient who developed obstructive jaundice 8 months following LC from a spilled gallstone. In our review of the literature using MEDLINE from January 1990to June 1995,we did not find this complication reported.
Published: 1996

47. Early aggressive surgical management of parapneumonic empyemas.

Author: Pothula V and Krellenstein DJ
Subjects: Adult, Aged, Aged, 80 and over, Algorithms, Chest Tubes, Child, Debridement, Drainage methods, Empyema, Pleural mortality, Female, Humans, Male, Middle Aged, Morbidity, Pleura surgery, Risk Factors, Time Factors, Empyema, Pleural surgery, Thoracotomy
Abstract: We have analyzed our experience with 90 consecutive patients who were operated on for parapneumonic empyema between 1981 and 1992. Patients whose empyema did not resolve with chest tube drainage were taken to the operating room. Nineteen patients had limited thoracotomy and drainage. Seventy-one patients had formal thoracotomy, debridement, pleurectomy, and decortication. We found that an age greater than 60 years, cardiac disease, end-stage renal disease, end-stage bronchitis, prolonged tube drainage, and immunosuppression are associated with increased morbidity and mortality. In those patients who do not respond well to a short course of chest tube drainage, we recommend early aggressive surgical approach, including formal thoracotomy and definitive treatment. This allowed for early discharge from the hospital without chest tubes or open draining wounds. In extremely ill patients, limited thoracotomy may be all that is safe or possible and usually suffices.
Published: 1994
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48. Gonadotropin-producing benign cystic teratoma simulating a ruptured ectopic pregnancy.

Author: Pothula V, Matseoane S, and Godfrey H
Subjects: Adult, Chorionic Gonadotropin blood, Chorionic Gonadotropin, beta Subunit, Human, Diagnostic Errors, Female, Humans, Ovarian Neoplasms metabolism, Peptide Fragments blood, Pregnancy, Rupture, Spontaneous, Teratoma metabolism, Chorionic Gonadotropin biosynthesis, Hormones, Ectopic biosynthesis, Ovarian Neoplasms diagnosis, Peptide Fragments biosynthesis, Pregnancy, Ectopic diagnosis, Teratoma diagnosis
Abstract: Benign cystic teratomas are asymptomatic in many cases. There are some reports of production of thyroid-stimulating hormone, estrogen, testosterone, and prolactin by these tumors. This article reports a patient in whom a twisted cystic teratoma simulated ruptured ectopic pregnancy by beta human chorionic gonadotropin production and hemorrhage into the peritoneal cavity.
Published: 1994

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