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189 results on '"Pottier N"'

1. Single-cell RNA-seq characterization of lung fibrosis resolution reveals a delayed capillary endothelial signature associated with alveolar regeneration in aged mice

Author

Truchi, M., primary, Savary, G., additional, Lebrigand, K., additional, Baeri, A., additional, Girard-Riboulleau, C., additional, Magnone, V., additional, Leroy, S., additional, Hofman, V., additional, Hofman, P., additional, Barbry, P., additional, Bellusci, S., additional, Cauffiez, C., additional, Vassaux, G., additional, Pottier, N., additional, and Mari, B., additional

Published
2023
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11. Implication de miR-21 dans les agressions rénales

Author

Van Der Hauwaert, C., primary, Hennino, M.F., additional, Vandenbussche, C., additional, Dewaeles, E., additional, Gnemmi, V., additional, Savary, G., additional, Pottier, N., additional, Glowacki, F., additional, and Cauffiez, C., additional

Published
2018
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13. Targeting the DNM3OS / miR-199a~214 cluster for the treatment of fibroproliferative diseases

Author

Savary, G., primary, Buscot, M., additional, Dewaeles, E., additional, Diazzi, S., additional, Nottet, N., additional, Courcot, E., additional, Fassy, J., additional, Lebrigand, K., additional, Henaoui, I. S., additional, Martis, N., additional, Van der Hauwaert, C., additional, Leroy, S., additional, Plantier, L., additional, Paquet, A., additional, Lino Cardenas, C. L., additional, Vassaux, G., additional, Crestani, B., additional, Wallaert, B., additional, Rezzonico, R., additional, Brousseau, T., additional, Glowacki, F., additional, Bellusci, S., additional, Perrais, M., additional, Broly, F., additional, Barbry, P., additional, Marquette, C. H., additional, Cauffiez, C., additional, Mari, B., additional, and Pottier, N., additional

Published
2018
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14. Copy-number analysis identified new prognostic marker in acute myeloid leukemia

Author

Nibourel, O, primary, Guihard, S, additional, Roumier, C, additional, Pottier, N, additional, Terre, C, additional, Paquet, A, additional, Peyrouze, P, additional, Geffroy, S, additional, Quentin, S, additional, Alberdi, A, additional, Abdelali, R B, additional, Renneville, A, additional, Demay, C, additional, Celli-Lebras, K, additional, Barbry, P, additional, Quesnel, B, additional, Castaigne, S, additional, Dombret, H, additional, Soulier, J, additional, Preudhomme, C, additional, and Cheok, M H, additional

Published
2016
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17. Efficacy of amniotic membrane transplantation in the treatment of leg ulcers

Author

Mermet , I., Cairey-Remonnay , Sandrine, Pottier , N., Sainthillier , J.M., Malugani , C., Maddens , Stéphane, Riethmuller , Didier, Tiberghien , Pierre, Humbert , Philippe, Aubin , François, Département de dermatologie, Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ) -Hôpital Saint-Jacques-Université de Franche-Comté ( UFC ), EFS Rhône-Alpes, EFS, Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC ( CEF2P / CARCINO ), Université Bourgogne Franche-Comté ( UBFC ) -Université de Franche-Comté ( UFC ) -Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ), Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC ( HOTE GREFFON ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Etablissement français du sang [Bourgogne-France-Comté] ( EFS [Bourgogne-France-Comté] ) -Université de Franche-Comté ( UFC ), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Hôpital Saint-Jacques-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (EA 3181) (CEF2P / CARCINO), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) (RIGHT), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Franche-Comté (UFC), and Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS [Bourgogne-Franche-Comté])

Subjects
[SDV.CAN]Life Sciences [q-bio]/Cancer, [ SDV.CAN ] Life Sciences [q-bio]/Cancer
Published
2006

19. miR-199a-5p Is Upregulated during Fibrogenic Response to Tissue Injury and Mediates TGFbeta-Induced Lung Fibroblast Activation by Targeting Caveolin-1

Author

Lino Cardenas, CL, Henaoui, IS, Courcot, E, Roderburg, C, Cauffiez, C, Aubert, S, Copin, MC, Wallaert, B, Glowacki, F, Dewaeles, E, Milosevic, J, Maurizio, J, Tedrow, J, Marcet, B, Lo-Guidice, JM, Kaminski, N, Barbry, P, Luedde, T, Perrais, M, Mari, B, Pottier, N, Lino Cardenas, CL, Henaoui, IS, Courcot, E, Roderburg, C, Cauffiez, C, Aubert, S, Copin, MC, Wallaert, B, Glowacki, F, Dewaeles, E, Milosevic, J, Maurizio, J, Tedrow, J, Marcet, B, Lo-Guidice, JM, Kaminski, N, Barbry, P, Luedde, T, Perrais, M, Mari, B, and Pottier, N

Published
2013

20. The SWI/SNF chromatin-remodeling complex and glucocorticoid resistance in acute lymphoblastic leukemia

Author

Pottier, N. (Nicolas), Yang, W. (Wenjian), Assem, M. (Mahfoud), Panetta, J.C. (John), Pei, D. (Deqing), Paugh, S.W. (Steven), Cheng, C. (Cheng), Boer, M.L. (Monique) den, Relling, M.V. (Mary), Pieters, R. (Rob), Evans, W.E. (William), Cheok, M.H. (Meyling), Pottier, N. (Nicolas), Yang, W. (Wenjian), Assem, M. (Mahfoud), Panetta, J.C. (John), Pei, D. (Deqing), Paugh, S.W. (Steven), Cheng, C. (Cheng), Boer, M.L. (Monique) den, Relling, M.V. (Mary), Pieters, R. (Rob), Evans, W.E. (William), and Cheok, M.H. (Meyling)

Abstract

Background: Glucocorticoids are used in the curative treatment of acute lymphoblastic leukemia (ALL). Resistance to glucocorticoids is an important adverse prognostic factor in newly diagnosed ALL patients but its mechanism is unknown. Because SWI/SNF complex-mediated chromatin remodeling is required for glucocorticoid transcriptional activity in vitro, we investigated whether expression of subunits of the SWI/SNF complex was related to glucocorticoid resistance in ALL. Methods: Gene expression and in vitro sensitivity to prednisolone and dexamethasone were assessed in a training set of primary ALL cells from 177 children with newly diagnosed ALL and a validation set of cells from an independent cohort of 95 ALL patients. The global test method was used to select pathways whose genes were associated with drug sensitivity. Genes involved in chromatin remodeling were identified by use of the Gene Ontology database. Short hairpin RNA (shRNA) was used to knock down mRNA expression of SMARCA4 in glucocorticoid-sensitive Jurkat human ALL cells. Spearman rank correlation, multiple linear regression, and logistic regression were used to investigate associations between gene expression and glucocorticoid sensitivity. All statistical tests were two-sided. Results: Statistically significant associations between decreased expression in ALL cells of genes for core subunits of the SWI/SNF complex - SMARCA4, ARID1A, and SMARCB1 - and resistance to prednisolone and dexamethasone were identified in the training cohort. In the validation cohort, expression of SMARCA4 (P <. 001 and r = -0.43), ARID1A (P =. 016 and r = -0.29), and SMARCB1 (P =. 019 and r = -0.29) in ALL cells was statistically significantly associated with dexamethasone sensitivity, and SMARCA4 expression (P =. 018 and r = -0.28) was statistically significantly associated with prednisolone sensitivity. Prednisolone resistance was higher in SMARCA4 shRNA-transfected Jurkat cells (drug concentration lethal to 50% of the

Published
2008
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22. Une décennie (2001–2010) de test génétique à l’hôpital européen Georges-Pompidou pour les patients atteints de paragangliome

Author

Buffet, A., primary, Venisse, A., additional, Nau, V., additional, Roncellin, I., additional, Boccio, V., additional, Le Pottier, N., additional, Boussion, M., additional, Travers, C., additional, Simian, M.-C., additional, Burnichon, N., additional, Abermil, N., additional, Favier, J., additional, Jeunemaitre, X., additional, and Gimenez-Roqueplo, A.-P., additional

Published
2012
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23. A Decade (2001-2010) of Genetic Testing for Pheochromocytoma and Paraganglioma

Author

Buffet, A., additional, Venisse, A., additional, Nau, V., additional, Roncellin, I., additional, Boccio, V., additional, Le Pottier, N., additional, Boussion, M., additional, Travers, C., additional, Simian, C., additional, Burnichon, N., additional, Abermil, N., additional, Favier, J., additional, Jeunemaitre, X., additional, and Gimenez-Roqueplo, A.-P., additional

Published
2012
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34. Relationships between early inflammatory response to bleomycin and sensitivity to lung fibrosis: a role for dipeptidyl-peptidase I and tissue inhibitor of metalloproteinase-3?

Author

Pottier N, Chupin C, Defamie V, Cardinaud B, Sutherland R, Rios G, Gauthier F, Wolters PJ, Berthiaume Y, Barbry P, Mari B, Pottier, Nicolas, Chupin, Cécile, Defamie, Virginie, Cardinaud, Bruno, Sutherland, Rachel, Rios, Géraldine, Gauthier, Francis, Wolters, Paul J, and Berthiaume, Yves

Abstract

Rationale: Different sensitivities to profibrotic compounds such as bleomycin are observed among mouse strains. Objectives: To identify genetic factors contributing to the outcome of lung injury. Methods: Physiological comparison of C57BL/6 (sensitive) and BALB/c (resistant) mice challenged by intratracheal bleomycin instillation revealed several early differences: global gene expression profiles were thus established from lungs derived from the two strains, in the absence of any bleomycin administration. Measurements and Main Results: Expression of 25 genes differed between the two strains. Among them, two molecules, not previously associated with pulmonary fibrosis, were identified. The first corresponded to dipeptidyl-peptidase I (DPPI), a cysteine peptidase (also known as cathepsin C) essential for the activation of serine proteinases produced by immune/inflammatory cells. The second corresponded to tissue inhibitor of matrix metalloproteinase-3, which also inhibits members of the ADAM (a disintegrin and metalloproteinase) family, such as the tumor necrosis factor-converting enzyme. In functional studies performed in the bleomycin-induced lung fibrosis model, the level of expression of these two genes was closely correlated with specific early events associated with lung fibrosis, namely activation of polymorphonuclear neutrophil-derived serine proteases and tumor necrosis factor-alpha-dependent inflammatory syndrome. Surprisingly, genetic deletion of DPPI in the context of a C57BL/6 genetic background did not protect against bleomycin-mediated fibrosis, suggesting additional function(s) for this key enzyme. Conclusions: This study highlights the importance of the early inflammatory events that follow bleomycin instillation in the development of lung fibrosis, and describes for the first time the roles that DPPI and tissue inhibitor of matrix metalloproteinase-3 may play in this process. [ABSTRACT FROM AUTHOR]

Published
2007
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42. MICRORNAS AS NEW PLAYERS OF INFLAMMATION

Author

Mari, B., Rezzonicco, R., Zaragosi, L. E., Pottier, N., Marcet, B., Chevalier, B., Bertero, T., Puissegur, M. P., Grosso, S., Robbe-Sermesant, K., Lebrigand, K., Rios, G., Fourre, S., Magnone, V., Ponzio, G., Rainer Waldmann, and Barbry, P.

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