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13. Usefulness of lead isotopes analysis in a pediatric case of chronic lead poisoning.

Author

Dufayet, L., Poupon, J., Vodovar, D., and Langrand, J.

Subjects
*LEAD poisoning, *LEAD isotopes, *ISOTOPIC analysis, *LEAD exposure, *X-ray fluorescence, *LASER ablation inductively coupled plasma mass spectrometry
Abstract

Identifying the source of lead is a key measure in the management of childhood lead poisoning. In cases with multiple potential sources or with unusual circumstances, this identification can be complex. By comparing the lead isotopic ratios (IRs) between the potential sources and the blood sample from the patient, it is possible to identify which source caused the poisoning. We report here the case of a 13-years-old girl, screened for lead poisoning as she was known to eat paint chips from two walls in her apartment. Her blood lead level was 395 µg/L, and the environmental investigation came back negative. X-ray fluorescence found lead concentration in paints to be below the regulatory threshold of 1 mg/cm2. As there was no other potential source of lead exposure in this case, a comparative analysis of the IRs of lead between the child's blood and two presumed sources (bathroom and kitchen paints) was performed. This analysis confirmed the source of lead intoxication to be the paints in the apartment, mostly from the bathroom wall. [ABSTRACT FROM AUTHOR]

Published
2023
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33. The 'relics of Joan of Arc': a forensic multidisciplinary analysis

Author

Charlier, P., Poupon, J., Eb, A., De Mazancourt, P., Gilbert, T., Huynh-Charlier, I., Loublier, Y., Verhille, A.M., Moulheirat, C., Willerslev, Patou-Mathis, M., de la Grandmaison, G. Lorin, and Durigon, M.

Subjects
DNA identification -- Research, Cremation -- Research, Forensic anthropology -- Research, Paleopathology -- Research, Relics -- Research, Law
Abstract

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.forsciint.2009.09.006 Byline: P. Charlier (a)(b), J. Poupon (c), A. Eb (d), P. De Mazancourt (e), T. Gilbert (f), I. Huynh-Charlier (g), Y. Loublier (h), A.M. Verhille (h), C. Moulheirat (i), M. Patou-Mathis (j), L. Robbiola (k), R. Montagut (l), F. Masson (m), A. Etcheberry (d), L. Brun (n), E. Willerslev (f), G. Lorin de la Grandmaison (a), M. Durigon (a) Keywords: Forensic anthropology; Paleopathology; Joan of Arc; Relic; DNA analysis; Elementary analysis; Cremation; Archaeology Abstract: Archaeological remains can provide concrete cases, making it possible to develop, refine or validate medico-legal techniques. In the case of the so-called 'Joan of Arc's relics' (a group of bone and archaeological remains known as the 'Bottle of Chinon'), 14 specialists analysed the samples such as a cadaver X of carbonised aspect: forensic anthropologist, medical examiners, pathologists, geneticists, radiologist, biochemists, palynologists, zoologist and archaeologist. Materials, methods and results of this study are presented here. This study aims to offer an exploitable methodology for the modern medico-legal cases of small quantities of human bones of carbonised aspect. Author Affiliation: (a) Department of Forensic Medicine and Pathology, University Hospital Raymond Poincare (AP-HP, UVSQ), 92380 Garches, France (b) HALMA-IPEL (UMR 8164, CNRS), Lille 3 University, Villeneuve d'Ascq, France (c) Laboratory of Biological Toxicology, Lariboisiere Hospital (AP-HP), rue Ambroise Pare, 75010 Paris, France (d) Lavoisier Institute, Versailles (UVSQ), France (e) Department of Forensic Genetic, University Hospital Raymond Poincare (AP-HP, UVSQ), 92380 Garches, France (f) Biological and Niels Bohr Institutes, University of Copenhagen, Denmark (g) Department of Radiology, La Pitie Salpetriere Hospital (AP-HP), Boulevard de l'HA[acute accent]pital, 75013 Paris, France (h) Laboratory of Palynology, National Museum of National History, Paris, France (i) Centre d'Etude et de Recherche sur les Textiles Anciens, Paris, France (j) Institute of Human Paleontology, 75013 Paris, France (k) Ecole Nationale Superieure de Chimie, Paris, France (l) Expert in Medicine and Pharmacy Fine Arts, France (m) Association des Amis du Vieux Chinon, Chinon, France (n) Department of Pathology, Faculty of Medicine, Parakou, Benin Article History: Received 14 March 2008; Revised 2 September 2009; Accepted 13 September 2009

Published
2010

35. Exchangeable copper: a reflection of the neurological severity in Wilson's disease

Author

Poujois, A., primary, Trocello, J.-M., additional, Djebrani-Oussedik, N., additional, Poupon, J., additional, Collet, C., additional, Girardot-Tinant, N., additional, Sobesky, R., additional, Habès, D., additional, Debray, D., additional, Vanlemmens, C., additional, Fluchère, F., additional, Ory-Magne, F., additional, Labreuche, J., additional, Preda, C., additional, and Woimant, F., additional

Published
2016
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36. Cuivre échangeable : un reflet de la sévérité de l’atteinte extra-hépatique dans la maladie de Wilson

Author

Poujois, A., primary, Djebrani-Oussedik, N., additional, Sobesky, R., additional, Tinant, N., additional, Collet, C., additional, Habès, D., additional, Debray, D., additional, Vanlemmens, C., additional, Fluchère, F., additional, Ory-Magne, F., additional, Labreuche, J., additional, Duclos-Vallée, J.-C., additional, Poupon, J., additional, and Woimant, F., additional

Published
2016
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43. Protocol of the national study of sources of exposure to lead in French dwellings

Author

Briand, E., Le Bot, Barbara, Poupon, J., Ginot, L., Glorennec, Philippe, Etchevers, Anne, École des Hautes Études en Santé Publique [EHESP] (EHESP), Groupe d'Etude de la Reproduction Chez l'Homme et les Mammiferes (GERHM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Institut de Veille Sanitaire (INVS), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Brébion, Alice

Subjects
[SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, Lead, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, French dwellings, [SDV.EE.SANT] Life Sciences [q-bio]/Ecology, environment/Health, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Published
2008

44. Evaluation of tumoral enhancement by superparamagnetic iron oxide particles: comparative studies with ferumoxtran and anionic iron oxide nanoparticles

Author

Bertrand Bessoud, Pierre-Yves Brillet, Nathalie Siauve, C.A. Cuenod, Florence Gazeau, Poupon J, Alain Luciani, Olivier Clément, and Jean-Noel Pons

Subjects
Intracellular Fluid, Male, medicine.medical_specialty, Relaxometry, Biodistribution, Skin Neoplasms, media_common.quotation_subject, Iron, Kinetics, Contrast Media, Mice, Nude, Adenocarcinoma, chemistry.chemical_compound, Mice, Nuclear magnetic resonance, In vivo, medicine, Tumor Cells, Cultured, Animals, Humans, Radiology, Nuclear Medicine and imaging, Tissue Distribution, Internalization, Magnetite Nanoparticles, media_common, business.industry, Spectrum Analysis, Electron Spin Resonance Spectroscopy, Prostatic Neoplasms, Dextrans, Extracellular Fluid, Oxides, General Medicine, Image Enhancement, In vitro, Ferrosoferric Oxide, Nanostructures, Disease Models, Animal, chemistry, Spin echo, Radiology, Nuclear medicine, business, Iron oxide nanoparticles, Neoplasm Transplantation
Abstract

This study was designed to compare tumor enhancement by superparamagnetic iron oxide particles, using anionic iron oxide nanoparticles (AP) and ferumoxtran. In vitro, relaxometry and media with increasing complexity were used to assess the changes in r2 relaxivity due to cellular internalization. In vivo, 26 mice with subcutaneously implanted tumors were imaged for 24 h after injection of particles to describe kinetics of enhancement using T1 spin echo, T2 spin echo, and T2 fast spin echo sequences. In vitro, the r2 relaxivity decreased over time (0–4 h) when AP were uptaken by cells. The loss of r2 relaxivity was less pronounced with long (Hahn Echo) than short (Carr–Purcell–Meiboom–Gill) echo time sequences. In vivo, our results with ferumoxtran showed an early T2 peak (1 h), suggesting intravascular particles and a second peak in T1 (12 h), suggesting intrainterstitial accumulation of particles. With AP, the late peak (24 h) suggested an intracellular accumulation of particles. In vitro, anionic iron oxide nanoparticles are suitable for cellular labeling due to a high cellular uptake. Conversely, in vivo, ferumoxtran is suitable for passive targeting of tumors due to a favorable biodistribution.

Published
2004

46. The 'relics of Joan of Arc':a forensic multidisciplinary analysis

Author

Charlier, P., Poupon, J., Eb, A., De Mazancourt, P., Gilbert, M. Thomas P., Huynh-Charlier, I., Loublier, Y., Verhille, A. M., Moulheirat, C., Patou-Mathis, M., Robbiola, L., Montagut, R., Masson, F., Etcheberry, A., Brun, L., Willerslev, Eske, de la Grandmaison, G. Lorin, Durigon, M., Charlier, P., Poupon, J., Eb, A., De Mazancourt, P., Gilbert, M. Thomas P., Huynh-Charlier, I., Loublier, Y., Verhille, A. M., Moulheirat, C., Patou-Mathis, M., Robbiola, L., Montagut, R., Masson, F., Etcheberry, A., Brun, L., Willerslev, Eske, de la Grandmaison, G. Lorin, and Durigon, M.

Abstract

Archaeological remains can provide concrete cases, making it possible to develop, refine or validate medico-legal techniques. In the case of the so-called 'Joan of Arc's relics' (a group of bone and archaeological remains known as the 'Bottle of Chinon'), 14 specialists analysed the samples such as a cadaver X of carbonised aspect: forensic anthropologist, medical examiners, pathologists, geneticists, radiologist, biochemists, palynologists, zoologist and archaeologist. Materials, methods and results of this study are presented here. This study aims to offer an exploitable methodology for the modern medico-legal cases of small quantities of human bones of carbonised aspect.

Published
2010

50. Maladie de Wilson

Author

Woimant, F., primary, Trocello, J.-M., additional, Girardot-Tinant, N., additional, Chaine, P., additional, Sobesky, R., additional, Duclos-Vallée, J.-C., additional, Chappuis, P., additional, El Balkhi, S., additional, and Poupon, J., additional

Published
2013
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