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Your search keyword '"Pourier, Milanthy S."' showing total 14 results
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14 results on '"Pourier, Milanthy S."'

8. Refining the 10-Year Prediction of Left Ventricular Systolic Dysfunction in Long-Term Survivors of Childhood Cancer

Author

Zorg en O&O, Child Health, Arts-assistenten Kinderen, Leerink, Jan M, van der Pal, Helena J H, Kremer, Leontien C M, Feijen, Elizabeth A M, Meregalli, Paola G, Pourier, Milanthy S, Merkx, Remy, Bellersen, Louise, van Dalen, Elvira C, Loonen, Jacqueline, Pinto, Yigal M, Kapusta, Livia, Mavinkurve-Groothuis, Annelies M C, Kok, Wouter E M, Zorg en O&O, Child Health, Arts-assistenten Kinderen, Leerink, Jan M, van der Pal, Helena J H, Kremer, Leontien C M, Feijen, Elizabeth A M, Meregalli, Paola G, Pourier, Milanthy S, Merkx, Remy, Bellersen, Louise, van Dalen, Elvira C, Loonen, Jacqueline, Pinto, Yigal M, Kapusta, Livia, Mavinkurve-Groothuis, Annelies M C, and Kok, Wouter E M

Published
2021

11. Biomarkers to diagnose ventricular dysfunction in childhood cancer survivors: a systematic review

Author

Leerink, Jan M, primary, Verkleij, Simone J, additional, Feijen, Elizabeth A M, additional, Mavinkurve-Groothuis, Annelies M C, additional, Pourier, Milanthy S, additional, Ylänen, Kaisa, additional, Tissing, Wim J E, additional, Louwerens, Marloes, additional, van den Heuvel, Marry M, additional, van Dulmen-den Broeder, Eline, additional, de Vries, Andrica C H, additional, Ronckers, Cecile M, additional, van der Pal, Heleen J H, additional, Kapusta, Livia, additional, Loonen, Jacqueline, additional, Bellersen, Louise, additional, Pinto, Yigal M, additional, Kremer, Leontien C M, additional, and Kok, Wouter E M, additional

Published
2018
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12. Biomarkers to diagnose ventricular dysfunction in childhood cancer survivors: a systematic review.

Author

Leerink, Jan M., Verkleij, Simone J., Feijen, Elizabeth A. M., Mavinkurve-Groothuis, Annelies M. C., Pourier, Milanthy S., Ylänen, Kaisa, Tissing, Wim J. E., Louwerens, Marloes, van den Heuvel, Marry M., Broeder, Eline van Dulmen-den, de Vries, Andrica C. H., Ronckers, Cecile M., van der Pal, Heleen J. H., Kapusta, Livia, Loonen, Jacqueline, Louise Bellersen, Louise, Pinto, Yigal M., Kremer, Leontien C. M., Kok, Wouter E. M., and van Dulmen-den Broeder, Eline

Subjects
CHILDHOOD cancer, CANCER patients, BRAIN natriuretic factor, META-analysis, NITRIC oxide, HEART ventricle diseases, ANTHRACYCLINES, ANTINEOPLASTIC agents, COMPARATIVE studies, DIAGNOSTIC imaging, LEFT heart ventricle, RESEARCH methodology, MEDICAL cooperation, PEPTIDE hormones, PEPTIDES, RESEARCH, RESEARCH evaluation, TUMORS, SYSTEMATIC reviews, EVALUATION research, TROPONIN, BLOOD, PHARMACODYNAMICS
Abstract

Objective: To systematically review the literature and assess the diagnostic value of biomarkers in detection of late-onset left ventricular (LV) dysfunction in childhood cancer survivors (CCS) treated with anthracyclines.Methods: We systematically searched the literature for studies that evaluated the use of biomarkers for detection of LV dysfunction in CCS treated with anthracyclines more than 1 year since childhood cancer diagnosis. LV dysfunction definitions were accepted as an ejection fraction <50% or <55% and/or a fractional shortening <28%, <29% or <30%. Contingency tables were created to assess diagnostic accuracies of biomarkers for diagnosing LV dysfunction.Results: Of 1362 original studies screened, eight heterogeneous studies evaluating four different biomarkers in mostly asymptomatic CCS were included. In four studies, an abnormal N-terminal pro-B-type natriuretic peptide (NT-proBNP, cut-off range 63-125 ng/L) had low sensitivity (maximally 22%) and a specificity of up to 97% for detection of LV dysfunction. For troponin levels, in five studies one patient had an abnormal troponin value as well as LV dysfunction, while in total 127 patients had LV dysfunction without troponin elevations above cut-off values (lowest 0.01 ng/mL). Two studies that evaluated brain natriuretic peptide and nitric oxide were underpowered to draw conclusions.Conclusions: In individual studies, the diagnostic value of NT-proBNP for detection of LV dysfunction in CCS is limited. Troponins have no role in detecting late-onset LV dysfunction with cut-off values as low as 0.01 ng/mL. Further study on optimal NT-proBNP cut-off values for rule out or rule in of LV dysfunction is warranted. [ABSTRACT FROM AUTHOR]

Published
2019
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