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1. EAES Multidisciplinary Rapid Guideline: systematic review, meta-analysis, GRADE assessment and evidence-informed recommendations on the surgical management of paraesophageal hernias

Author

Markar, Sheraz R., Menon, Nainika, Guidozzi, Nadia, Kontouli, Katerina-Maria, Mavridis, Dimitrios, Andreou, Alexandros, Berlth, Felix, Bonavina, Luigi, Cushieri, Alfred, Fourie, Lana, Gossage, James, Gronnier, Caroline, Hazebroek, Eric J., Krishnadath, Sheila, Low, Donald E., McCord, Mimi, Pouw, Roos E., Watson, David I., Carrano, Francesco Maria, Ortenzi, Monica, and Antoniou, Stavros A.

Published
2023
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2. The use of a real-time computer-aided detection system for visible lesions in the Barrett’s esophagus during live endoscopic procedures: a pilot study (with video)

Author

Alkhalaf, Alaa, Herrero, Lorenza Alvarez, Baldaque-Silva, Francisco, Barret, Maximilien, Bergman, Jacques J., Beyna, Torsten, Boers, Tim G., Elbe, Peter, Fockens, Kiki N., de Groof, Albert J., Houben, Martin H., Jong, Martijn, Jukema, Jelmer B., Kusters, Koen C., Mallant-Hent, Rosalie C., Villarejo, Guiomar Moral, Nagengast, Wouter, Fernández-Sordo, Jacobo Ortiz, Pech, Oliver, Pouw, Roos E., van der Putten, Joost A., Ragunath, Krish, Scholten, Pieter, Seewald, Stefan, der Sommen, Fons van, Westerhof, Jessie, Weusten, Bas L., de With, Peter H., Jong, Martijn R., Boers, Tim, Kusters, Carolus H.J., Duits, Lucas C., van der Sommen, Fons, and de Groof, A. Jeroen

Published
2024
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4. Incidence and Prediction of Unrelated Mortality After Successful Endoscopic Eradication Therapy for Barrett’s Neoplasia

Author

van Munster, Sanne.N., Verheij, Eva P.D., Ozdemir, Özge, Toes-Zoutendijk, Esther, Lansdorp-Vogelaar, Iris, Nieuwenhuis, Esther A., Cotton, Cary C., Weusten, Bas L.A.M., Alvarez Herrero, Lorenza, Alkhalaf, Alaa, Schenk, B. Ed, Schoon, Erik J., Curvers, Wouter L., Koch, Arjun D., de Jonge, Pieter-Jan F., Tang, Thjon J., Nagengast, Wouter B., Westerhof, Jessie, Houben, Martin H.M.G., Shaheen, Nicholas J., Bergman, Jacques J.G.H.M., and Pouw, Roos E.

Published
2024
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6. Western outcomes of circumferential endoscopic submucosal dissection for early esophageal squamous cell carcinoma

Author

Rodríguez de Santiago, Enrique, van Tilburg, Laurelle, Deprez, Pierre H., Pioche, Mathieu, Pouw, Roos E., Bourke, Michael J., Seewald, Stefan, Weusten, Bas L.A.M., Jacques, Jeremie, Leblanc, Sara, Barreiro, Pedro, Lemmers, Arnaud, Parra-Blanco, Adolfo, Küttner-Magalhães, Ricardo, Libânio, Diogo, Messmann, Helmut, Albéniz, Eduardo, Kaminski, Michal F., Mohammed, Noor, Ramos-Zabala, Felipe, Herreros-de-Tejada, Alberto, Huchima Koecklin, Hugo, Wallenhorst, Timothée, Santos-Antunes, João, Cunha Neves, João A., Koch, Arjun D., Ayari, Myriam, Garces-Duran, Rodrigo, Ponchon, Thierry, Rivory, Jérôme, Bergman, Jacques J.G.H.M., Verheij, Eva P.D., Gupta, Sunil, Groth, Stefan, Lepilliez, Vincent, Franco, Ana Rita, Belkhir, Sanaa, White, Jonathan, Ebigbo, Alanna, Probst, Andreas, Legros, Romain, Pilonis, Nastazja Dagny, de Frutos, Diego, Muñoz González, Raquel, and Dinis-Ribeiro, Mario

Published
2024
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8. Computer-aided diagnosis improves characterization of Barrett’s neoplasia by general endoscopists (with video)

Author

Alkhalaf, Alaa, Herrero, Lorenza Alvarez, Baldaque-Silva, Francisco, Barret, Maximilien, Bergman, Jacques J., Beyna, Torsten, Bisschops, Raf, Boers, Tim G., Curvers, Wouter, Deprez, Pierre H., Duits, Lucas C., Elbe, Peter, Esteban, Jose Miguel, Falk, Gary W., Fockens, Kiki N., Ginsberg, Gregory G., de Groof, Albert J., Haidry, Rehan, Houben, Martin H., Infantolino, Anthony, Iyer, Prasad G., Jong, Martijn, Jonge, Pieter-Jan de, Jukema, Jelmer B., Koch, Arjun, Komanduri, Srinadh, Konda, Vani, Kusters, Koen C., Leclerq, Philippe, Leggett, Cadman L., Lightdale, Charles J., Mallant-Hent, Rosalie C., Villarejo, Guiomar Moral, Fernández-Sordo, Jacobo Ortiz, Pech, Oliver, Penman, Ian, Pouw, Roos E., van der Putten, Joost A., Ragunath, Krish, Scholten, Pieter, Seewald, Stefan, Sethi, Amritha, Smith, Michael S., van der Sommen, Fons, Trindade, Arvind, Wani, Sachin, Waxman, Irving, Westerhof, Jessie, Weusten, Bas L., de With, Peter H., Wolfsen, Herbert C., Kusters, Carolus H.J., Jong, Martijn R., Boers, Tim, Weusten, Bas L.A.M., Houben, Martin H.M.G., Nagengast, Wouter B., Mallant-Hent, Rosalie, Silva, Francisco Baldaque, Ortiz Fernández-Sordo, Jacobo, Moral Villarejo, Guiomar, Montazeri, Nahid S.M., der Sommen, Fons van, and de Groof, A. Jeroen

Published
2024
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10. The Tissue Systems Pathology Test Outperforms Pathology Review in Risk Stratifying Patients With Low-Grade Dysplasia

Author

Goldblum, John, Montgomery, Elizabeth, Davison, Jon, Singh, Jagjit, Szymanski, Jared, Perry, Anthony, Seldenrijk, Kees, Kate, Fiebo ten, Offerhaus, G. Johan A., Drillenberg, Paul, Jansen, Casper, Leeuwis-Fedorovic, Natalja, Chetty, Runjan, Feakins, Roger, Jansen, Marnix, Chinyama, Catherine, Cooper, Edwin, Vaziri, Reza, Baretton, Gustavo, Tannapfel, Andrea, Vieth, Michael, Melcher, Balint, Mesteri, Ildiko, Müller, Heiko, Wetzel, Philipp, de Hertogh, Gert, Hoorens, Anne, Verschuere, Stepanie, Tamsin, An, Wetzels, Kevin, Caillie, Marie-Astrid van, Khoshiwal, Amir M., Frei, Nicola F., Pouw, Roos E., Smolko, Christian, Arora, Meenakshi, Siegel, Jennifer J., Duits, Lucas C., Critchley-Thorne, Rebecca J., and Bergman, Jacques J.G.H.M.

Published
2023
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11. Clinical Relevance of Random Biopsies From the Esophagogastric Junction After Complete Eradication of Barrett’s Esophagus is Low

Author

Frederiks, Charlotte N., van Munster, Sanne N., Nieuwenhuis, Esther A., Alvarez Herrero, Lorenza, Alkhalaf, Alaa, Schenk, Boudewijn E., Schoon, Erik J., Curvers, Wouter L., Koch, Arjun D., de Jonge, Pieter-Jan F., Tang, Thjon, Nagengast, Wouter B., Westerhof, Jessie, Houben, Martin H.M.G., Bergman, Jacques J.G.H.M., Pouw, Roos E., and Weusten, Bas L.A.M.

Published
2023
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14. Development and External Validation of a Model to Predict Complex Treatment After Radiofrequency Ablation for Barrett’s Esophagus With Early Neoplasia

Author

van Munster, Sanne N., Nieuwenhuis, Esther, Bisschops, Raf, Willekens, Hilde, Weusten, Bas L.A. M., Herrero, Lorenza Alvarez, Bogte, Auke, Alkhalaf, Alaa, Schenk, Ed B.E., Schoon, Erik J., Curvers, Wouter, Koch, Arjun D., de Jonge, Pieter Jan F., Tang, Tjon J., Nagengast, Wouter B., Westerhof, Jessie, Houben, Martin H.M. G., Bergman, Jacques J.G. H.M., and Pouw, Roos E.

Published
2022
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16. Safety and efficacy of salvage endoscopic submucosal dissection for Barrett's neoplasia recurrence after radiofrequency ablation.

Author

Mesureur, Lauriane, Deprez, Pierre H., Bisschops, Raf, Pouw, Roos E., Weusten, Bas L.A.M., Barret, Maximilien, Dewint, Pieter, Tate, David, Leclercq, Philippe, Seewald, Stefan, Barbaro, Federico, Baldaque-Silva, Francisco, Omae, Masami, Pioche, Mathieu, Figueiredo Ferreira, Mariana, Bourke, Michael J., Haidry, Rehan, Snauwaert, Christophe, Eisendrath, Pierre, and De Maertelaer, Viviane

Subjects
ELECTROCOAGULATION (Medicine), BARRETT'S esophagus, ENDOSCOPIC surgery, CATHETER ablation, TUMORS
Abstract

Background This study evaluated the safety and efficacy of salvage endoscopic submucosal dissection (ESD) for Barrett's neoplasia recurrence after radiofrequency ablation (RFA). Methods Data from patients at 16 centers were collected for a multicenter retrospective study. Patients who underwent at least one RFA treatment for Barrett's esophagus and thereafter underwent further esophageal ESD for neoplasia recurrence were included. Results Data from 56 patients who underwent salvage ESD between April 2014 and November 2022 were collected. Immediate complications included one muscular tear (1.8%) treated with stent (Agree classification: grade IIIa). Two transmural perforations (3.6%; treated with clips) and five muscular tears (8.9%; two treated with clips) had no clinical impact and were not considered as adverse events. Seven patients (12.5%) developed strictures (grade IIIa), which were treated with balloon dilation. Histological analysis showed 36 adenocarcinoma, 17 high grade dysplasia, and 3 low grade dysplasia. En bloc and R0 resection rates were 89.3% and 66.1%, respectively. Resections were curative in 33 patients (58.9%), and noncurative in 22 patients (39.3%), including 11 "local risk" (19.6%) and 11 "high risk" (19.6%) resections. At the end of follow-up with a median time of 14 (0–75) months after salvage ESD, and with further endoscopic treatment if necessary (RFA, argon plasma coagulation, endoscopic mucosal resection, ESD), neoplasia remission ratio was 37/53 (69.8%) and the median remission time was 13 (1–75) months. Conclusion In expert hands, salvage ESD was a safe and effective treatment for recurrence of Barrett's neoplasia after RFA treatment. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Vertical tumor-positive resection margins and the risk of residual neoplasia after endoscopic resection of Barrett's neoplasia: a nationwide cohort with pathology reassessment.

Author

van Tilburg, Laurelle, Verheij, Eva P. D., van de Ven, Steffi E. M., van Munster, Sanne N., Weusten, Bas L. A. M., Herrero, Lorenza Alvarez, Nagengast, Wouter B., Schoon, Erik J., Alkhalaf, Alaa, Bergman, Jacques J. G. H. M., Pouw, Roos E., Oudijk, Lindsey, Meijer, Sybren L., Jansen, Marnix, Doukas, Michail, Koch, Arjun D., Brosens, Lodewijk A. A., Curvers, Wouter L., Houben, Martin H. M. G., and de Jonge, Pieter Jan F.

Subjects
ENDOSCOPIC surgery, SURGICAL margin, SURGICAL excision, CANCER cells, TUMORS
Abstract

Background This study evaluated the proportion of patients with residual neoplasia after endoscopic resection (ER) for Barrett's neoplasia with confirmed tumor-positive vertical resection margin (R1v). Methods This retrospective cohort study included patients undergoing ER for Barrett's neoplasia with histologically documented R1v since 2008 in the Dutch Barrett Expert Centers. We defined R1v as cancer cells touching vertical resection margins and Rx as nonassessable margins. Reassessment of R1v specimens was performed by experienced pathologists until consensus was reached regarding vertical margins. Results 101/110 included patients had macroscopically complete resections (17 T1a, 84 T1b), and 99/101 (98%) ER specimens were histologically reassessed, with R1v confirmed in 74 patients (75%), Rx in 16%, and R0 in 9%. Presence/absence of residual neoplasia could be assessed in 66/74 patients during endoscopic reassessment (52) and/or in the surgical resection specimen (14), and 33/66 (50%) had residual neoplasia. Residual neoplasia detected during endoscopy was always endoscopically visible and biopsies from a normal-appearing ER scar did not detect additional neoplasia. Of 25 patients who underwent endoscopic follow-up (median 37 months [interquartile range 12–50]), 4 developed local recurrence (16.0%), all detected as visible abnormalities. Conclusions After ER with R1v, 50% of patients had no residual neoplasia. Histological evaluation of ER margins appears challenging, as in this study 75% of documented R1v cases were confirmed during reassessment. Endoscopic reassessment 8–12 weeks after ER seems to accurately detect residual neoplasia and can help to determine the most appropriate strategy for patients with R1v. [ABSTRACT FROM AUTHOR]

Published
2024
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18. COMPUTER-AIDED DIAGNOSIS IMPROVES CHARACTERIZATION OF BARRETT’S NEOPLASIA BY GENERAL ENDOSCOPISTS

Author

Jukema, Jelmer B., primary, Kusters, Carolus H.J., additional, Jong, Martijn R., additional, Fockens, Kiki N., additional, Boers, Tim, additional, van der Putten, Joost A., additional, Pouw, Roos E., additional, Duits, Lucas C., additional, Weusten, BasL.A.M., additional, Herrero, Lorenza. Alvarez, additional, Houben, Martin H.M.G., additional, Nagengast, Wouter B., additional, Westerhof, Jessie, additional, Alkhalaf, Alaa, additional, Mallant-Hent, Rosalie, additional, Scholten, Pieter, additional, Ragunath, Krish, additional, Seewald, Stefan, additional, Elbe, Peter, additional, Silva, Francisco Baldaque, additional, Barret, Maximilien, additional, Fernández-Sordo, Jacobo Ortiz, additional, Villarejo, Guiomar Moral, additional, Pech, Oliver, additional, Beyna, Torsten, additional, Montazeri, Nahid S.M., additional, van der Sommen, Fons, additional, de With, Peter H., additional, de Groof, A. Jeroen, additional, Bergman, Jacques J., additional, Herrero, Lorenza Alvarez, additional, Baldaque-Silva, Francisco, additional, Bisschops, Raf, additional, Boers, Tim G., additional, Curvers, Wouter, additional, Deprez, Pierre H., additional, Esteban, Jose Miguel, additional, Falk, Gary W., additional, Ginsberg, Gregory G., additional, de Groof, Albert J., additional, Haidry, Rehan, additional, Houben, Martin H., additional, Infantolino, Anthony, additional, Iyer, Prasad G., additional, Jong, Martijn, additional, Jonge, Pieter-Jan de, additional, Jukema, Jelmer B., additional, Koch, Arjun, additional, Komanduri, Srinadh, additional, Konda, Vani, additional, Kusters, Koen C., additional, Leclerq, Philippe, additional, Leggett, Cadman L., additional, Lightdale, Charles J., additional, Mallant-Hent, Rosalie C., additional, Muthusamy, V Raman, additional, Penman, Ian, additional, Sethi, Amritha, additional, Smith, Michael S., additional, Trindade, Arvind, additional, Wani, Sachin, additional, Waxman, Irving, additional, Weusten, Bas L., additional, and Wolfsen, Herbert C., additional

Published
2024
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19. The use of a real-time computer-aided detection system for visible lesions in the Barrett’s esophagus during live endoscopic procedures, a pilot study

Author

Fockens, Kiki N., primary, Jukema, Jelmer B., additional, Jong, Martijn R., additional, Boers, Tim, additional, van der Putten, Joost A., additional, Kusters, Carolus H.J., additional, Pouw, Roos E., additional, Duits, Lucas C., additional, Sommen, Fons van der, additional, de With, Peter H., additional, de Groof, A. Jeroen, additional, and Bergman, Jacques J., additional

Published
2024
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22. Incidence and Prediction of Unrelated Mortality After Successful Endoscopic Eradication Therapy for Barrett's Neoplasia

Author

van Munster, Sanne N., Verheij, Eva P.D., Ozdemir, Özge, Toes-Zoutendijk, Esther, Lansdorp-Vogelaar, Iris, Nieuwenhuis, Esther A., Cotton, Cary C., Weusten, Bas L.A.M., Alvarez Herrero, Lorenza, Alkhalaf, Alaa, Schenk, B. Ed, Schoon, Erik J., Curvers, Wouter L., Koch, Arjun D., de Jonge, Pieter Jan F., Tang, Thjon J., Nagengast, Wouter B., Westerhof, Jessie, Houben, Martin H.M.G., Shaheen, Nicholas J., Bergman, Jacques J.G.H.M., Pouw, Roos E., van Munster, Sanne N., Verheij, Eva P.D., Ozdemir, Özge, Toes-Zoutendijk, Esther, Lansdorp-Vogelaar, Iris, Nieuwenhuis, Esther A., Cotton, Cary C., Weusten, Bas L.A.M., Alvarez Herrero, Lorenza, Alkhalaf, Alaa, Schenk, B. Ed, Schoon, Erik J., Curvers, Wouter L., Koch, Arjun D., de Jonge, Pieter Jan F., Tang, Thjon J., Nagengast, Wouter B., Westerhof, Jessie, Houben, Martin H.M.G., Shaheen, Nicholas J., Bergman, Jacques J.G.H.M., and Pouw, Roos E.

Abstract

Background & Aims: Follow-up (FU) strategies after endoscopic eradication therapy (EET) for Barrett's neoplasia do not consider the risk of mortality from causes other than esophageal adenocarcinoma (EAC). We aimed to evaluate this risk during long-term FU, and to assess whether the Charlson Comorbidity Index (CCI) can predict mortality. Methods: We included all patients with successful EET from the nationwide Barrett registry in the Netherlands. Data were merged with National Statistics for accurate mortality data. We evaluated annual mortality rates (AMRs, per 1000 person-years) and standardized mortality ratio for other-cause mortality. Performance of the CCI was evaluated by discrimination and calibration. Results: We included 1154 patients with a mean age of 64 years (±9). During median 59 months (p25–p75 37–91; total 6375 person-years), 154 patients (13%) died from other causes than EAC (AMR, 24.1; 95% CI, 20.5–28.2), most commonly non-EAC cancers (n = 58), cardiovascular (n = 31), or pulmonary diseases (n = 26). Four patients died from recurrent EAC (AMR, 0.5; 95% CI, 0.1–1.4). Compared with the general Dutch population, mortality was significantly increased for patients in the lowest 3 age quartiles (ie, age <71 years). Validation of CCI in our population showed good discrimination (Concordance statistic, 0.78; 95% CI, 0.72–0.84) and fair calibration. Conclusion: The other-cause mortality risk after successful EET was more than 40 times higher (48; 95% CI, 15–99) than the risk of EAC-related mortality. Our findings reveal that younger post-EET patients exhibit a significantly reduced life expectancy when compared with the general population. Furthermore, they emphasize the strong predictive ability of CCI for long-term mortality after EET. This straightforward scoring system can inform decisions regarding personalized FU, including appropriate cessation timing.

Published
2024

23. Endoscopic submucosal dissection for early esophageal squamous cell carcinoma:long-term results from a Western cohort

Author

Beaufort, Ilse N., Frederiks, Charlotte N., Overwater, Anouk, Brosens, Lodewijk A. A., Koch, Arjun D., Pouw, Roos E., Bergman, Jacques J. G. H. M., Weusten, Bas L. A. M., Beaufort, Ilse N., Frederiks, Charlotte N., Overwater, Anouk, Brosens, Lodewijk A. A., Koch, Arjun D., Pouw, Roos E., Bergman, Jacques J. G. H. M., and Weusten, Bas L. A. M.

Abstract

Background Although endoscopic submucosal dissection (ESD) is established as first-choice treatment for early esophageal squamous cell carcinoma (ESCC) worldwide, most data are derived from Asian studies. We aimed to evaluate the long-term outcomes of ESD for patients with early ESCC in a Western cohort. Methods In this retrospective cohort study, patients with early ESCC amenable to ESD were included from four tertiary referral hospitals in the Netherlands between 2012 and 2017. All ESD procedures were performed by experienced endoscopists, after which the decision for additional treatment was made on a per-patient basis. Outcomes were curative resection rate, ESCC-specific survival, and overall survival. Results Of 68 included patients (mean age 69 years; 34 males), ESD was technically successful in 66 (97%; 95%CI 93%-100%), with curative resection achieved in 34/66 (52%; 95%CI 39%-64%). Among patients with noncurative resection, 15/32 (47%) underwent additional treatment, mainly esophagectomy (n = 10) or definitive chemoradiation therapy (n = 4). Endoscopic surveillance was preferred in 17/32 patients (53%), based on severe comorbidities or patient choice. Overall, 31/66 patients (47%) died during a median follow-up of 66 months; 8/31 (26%) were ESCC-related deaths. The 5-year overall and ESCC-specific survival probabilities were 62% (95%CI 52%-75%) and 86% (95%CI 77%-96%), respectively. Conclusion In this Western cohort with long-term follow-up, the effectiveness and safety of ESD for early ESCC was confirmed, although the rate of noncurative resections was substantial. Irrespective of curative status, the long-term prognosis of these patients was limited mainly due to competing mortality.

Published
2024

26. 300. ENDOSCOPIC FOLLOW-UP OF RADICALLY RESECTED SUBMUCOSAL ESOPHAGEAL ADENOCARCINOMA: PRELIMINARY RESULTS OF AN ONGOING PROSPECTIVE, INTERNATIONAL, MULTICENTER COHORT REGISTRY (PREFER TRIAL)

Author

Pouw, Roos, primary, Nieuwenhuis, Esther, additional, Jansen, Marnix, additional, Koch, Arjun, additional, Spaander, Manon, additional, Nagengast, Wouter, additional, Westerhof, Jessie, additional, Bisschops, Raf, additional, De Hertogh, Gert, additional, Neuhaus, Horst, additional, Beyna, Torsten, additional, Bourke, Michael, additional, Weusten, Bas, additional, Alkhalaf, Alaa, additional, Pech, Oliver, additional, Seewald, Stefan, additional, Haidry, Rehan, additional, Schoon, Erik, additional, Schlag, Christoph, additional, De Wulf, Dominiek, additional, Houben, Martin, additional, Messman, Helmut, additional, Dewint, Pieter, additional, Ortiz, Jacobo, additional, Meijer, Sybren, additional, Bergman, Jacques, additional, and Pouw, Roos, additional

Published
2023
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27. A deep learning system for detection of early Barrett's neoplasia: a model development and validation study

Author

Fockens, K N, primary, Jong, M R, additional, Jukema, J B, additional, Boers, T G W, additional, Kusters, C H J, additional, van der Putten, J A, additional, Pouw, R E, additional, Duits, L C, additional, Montazeri, N S M, additional, van Munster, S N, additional, Weusten, B L A M, additional, Alvarez Herrero, L, additional, Houben, M H M G, additional, Nagengast, W B, additional, Westerhof, J, additional, Alkhalaf, A, additional, Mallant-Hent, R C, additional, Scholten, P, additional, Ragunath, K, additional, Seewald, S, additional, Elbe, P, additional, Baldaque-Silva, F, additional, Barret, M, additional, Ortiz Fernández-Sordo, J, additional, Villarejo, G Moral, additional, Pech, O, additional, Beyna, T, additional, van der Sommen, F, additional, de With, P H, additional, de Groof, A J, additional, Bergman, J J, additional, Alkhalaf, Alaa, additional, Alvarez Herrero, Lorenza, additional, Baldaque-Silva, Francisco, additional, Barret, Maximilien, additional, Bergman, Jacques J, additional, Beyna, Torsten, additional, Bisschops, Raf, additional, Boers, Tim G, additional, Curvers, Wouter, additional, Deprez, Pierre H, additional, Duits, Lucas C, additional, Elbe, Peter, additional, Esteban, Jose M, additional, Falk, Gary W, additional, Fockens, Kiki N, additional, Ganguly, Eric, additional, Ginsberg, Gregory G, additional, de Groof, Albert J, additional, Haidry, Rehan, additional, Houben, Martin H, additional, Infantolino, Anthony, additional, Iyer, Prasad G, additional, Jong, Martijn R, additional, De Jonge, Pieter-Jan, additional, Jukema, Jelmer B, additional, Koch, Arjun K, additional, Komanduri, Srinadh, additional, Konda, Vani, additional, Kusters, Carolus H J, additional, Leclercq, Philippe, additional, Leggett, Cadman L, additional, Lemmers, Arnaud, additional, Lightdale, Charles J, additional, Mallant-Hent, Rosalie C, additional, Moral Villarejo, Guiomar, additional, Muthusamy, V Raman, additional, Nagengast, Wouter, additional, Ortiz Fernández-Sordo, Jacobo, additional, Pech, Oliver, additional, Penman, Ian, additional, Pleskow, Douglas K, additional, Pouw, Roos E, additional, van der Putten, Joost A, additional, Ragunath, Krish, additional, Scholten, Pieter, additional, Seewald, Stefan, additional, Sethi, Amritha, additional, Smith, Michael S, additional, Van der Sommen, Fons, additional, Trindade, Arvind, additional, Wani, Sachin, additional, Waxman, Irving, additional, Westerhof, Jessie, additional, Weusten, Bas L, additional, de With, Peter H N, additional, and Wolfsen, Herbert C, additional

Published
2023
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31. Phenotypic immune characterization of gastric and esophageal adenocarcinomas reveals profound immune suppression in esophageal tumor locations.

Author

Groen-van Schooten, Tessa S., Harrasser, Micaela, Seidel, Jens, Bos, Emma N., Fleitas, Tania, van Mourik, Monique, Pouw, Roos E., Goedegebuure, Ruben S. A., Doeve, Benthe H., Sanders, Jasper, Bos, Joris, van Berge Henegouwen, Mark I., Thijssen, Victor L. J. L., van Grieken, Nicole C. T., van Laarhoven, Hanneke W. M., de Gruijl, Tanja D., and Derks, Sarah

Subjects
ESOPHAGEAL tumors, MYELOID-derived suppressor cells, IMMUNOSUPPRESSION, ADENOCARCINOMA, T cells
Abstract

Background: Tumors in the distal esophagus (EAC), gastro-esophageal junction including cardia (GEJAC), and stomach (GAC) develop in close proximity and show strong similarities on a molecular and cellular level. However, recent clinical data showed that the effectiveness of chemo-immunotherapy is limited to a subset of GEAC patients and that EACs and GEJACs generally benefit less from checkpoint inhibition compared to GACs. As the composition of the tumor immune microenvironment drives response to (immuno)therapy we here performed a detailed immune analysis of a large series of GEACs to facilitate the development of a more individualized immunomodulatory strategy. Methods: Extensive immunophenotyping was performed by 14-color flow cytometry in a prospective study to detail the immune composition of untreated gastro-esophageal cancers (n=104) using fresh tumor biopsies of 35 EACs, 38 GEJACs and 31 GACs. The immune cell composition of GEACs was characterized and correlated with clinicopathologic features such as tumor location, MSI and HER2 status. The spatial immune architecture of a subset of tumors (n=30) was evaluated using multiplex immunohistochemistry (mIHC) which allowed us to determine the tumor infiltration status of CD3+, CD8+, FoxP3+, CD163+ and Ki67+ cells. Results: Immunophenotyping revealed that the tumor immune microenvironment of GEACs is heterogeneous and that immune suppressive cell populations such as monocytic myeloid-derived suppressor cells (mMDSC) are more abundant in EACs compared to GACs (p<0.001). In contrast, GACs indicated a proinflammatory microenvironment with elevated frequencies of proliferating (Ki67+) CD4 Th cells (p<0.001), Ki67+ CD8 T cells (p=0.002), and CD8 effector memory-T cells (p=0.024). Differences between EACs and GACs were confirmed by mIHC analyses showing lower densities of tumor- and stroma-infiltrating Ki67+ CD8 T cells in EAC compared to GAC (both p=0.021). Discussions: This comprehensive immune phenotype study of a large series of untreated GEACs, identified that tumors with an esophageal tumor location have more immune suppressive features compared to tumors in the gastro-esophageal junction or stomach which might explain the location-specific responses to checkpoint inhibitors in this disease. These findings provide an important rationale for stratification according to tumor location in clinical studies and the development of location-dependent immunomodulatory treatment approaches. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Diagnosis and management of Barrett esophagus: European Society of Gastrointestinal Endoscopy (ESGE) Guideline

Author

Weusten, Bas L. A. M., additional, Bisschops, Raf, additional, Dinis-Ribeiro, Mario, additional, di Pietro, Massimiliano, additional, Pech, Oliver, additional, Spaander, Manon C. W., additional, Baldaque-Silva, Francisco, additional, Barret, Maximilien, additional, Coron, Emmanuel, additional, Fernández-Esparrach, Glòria, additional, Fitzgerald, Rebecca C., additional, Jansen, Marnix, additional, Jovani, Manol, additional, Marques-de-Sa, Ines, additional, Rattan, Arti, additional, Tan, W. Keith, additional, Verheij, Eva P. D., additional, Zellenrath, Pauline A., additional, Triantafyllou, Konstantinos, additional, and Pouw, Roos E., additional

Published
2023
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33. Western outcomes of circumferential endoscopic submucosal dissection for early esophageal squamous cell carcinoma

Author

Rodríguez de Santiago, Enrique, primary, van Tilburg, Laurelle, additional, Deprez, Pierre H., additional, Pioche, Mathieu, additional, Pouw, Roos E., additional, Bourke, Michael J., additional, Seewald, Stefan, additional, Weusten, BasLAM., additional, Jacques, Jeremie, additional, Leblanc, Sara, additional, Barreiro, Pedro, additional, Lemmers, Arnaud, additional, Parra-Blanco, Adolfo, additional, Küttner-Magalhães, Ricardo, additional, Libânio, Diogo, additional, Messmann, Helmut, additional, Albéniz, Eduardo, additional, Kaminski, Michal F., additional, Mohammed, Noor, additional, Zabala, Felipe Ramos, additional, Herreros-de-Tejada, Alberto, additional, Koecklin, Hugo Uchima, additional, Wallenhorst, Timothée, additional, Santos-Antunes, João, additional, Cunha Neves, João A., additional, Koch, Arjun D., additional, Ayari, Myriam, additional, Duran, Rodrigo Garces, additional, Ponchon, Thierry, additional, Rivory, Jérôme, additional, Bergman, Jacques J.G. H.M., additional, Verheij, Eva P.D., additional, Gupta, Sunil, additional, Groth, Stefan, additional, Lepilliez, Vincent, additional, Franco, Ana Rita, additional, Belkhir, Sanaa, additional, White, Jonathan, additional, Ebigbo, Alanna, additional, Probst, Andreas, additional, Legros, Romain, additional, Pilonis, Nastazja Dagny, additional, de Frutos, Diego, additional, González, Raquel Muñoz, additional, Dinis-Ribeiro, Mario, additional, Dano, Helene, additional, Deswysen, Yannick, additional, Moll, Frédéric, additional, Albouys, Jérémie, additional, Dahan, Martin, additional, Arisha, Muhammad Abu, additional, Maggio, Ewerton Marques, additional, Yakovenko, Vladyslav, additional, Félix, Catarina, additional, Fraile, Miguel, additional, Villarejo, Guiomar Moral, additional, Coutada, Andreia, additional, Nagl, Sandra, additional, Moreno, Eloisa Romero, additional, Winters, Conchubhair, additional, Santiago, José, additional, Torrego, Pedro, additional, Peñas, Beatriz, additional, and Parejo, Sofia, additional

Published
2023
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40. A prospective multicenter study using a new multiband mucosectomy device for endoscopic resection of early neoplasia in Barrett’s esophagus

Author

Pouw, Roos E., Beyna, Torsten, Belghazi, Kamar, Koch, Arjun D., Schoon, Erik J., Haidry, Rehan, Weusten, Bas L., Bisschops, Raf, Shaheen, Nicholas J., Wallace, Michael B., Marcon, Norman, Heise-Ginsburg, Rachel, Gotink, Anniek W., Wang, Kenneth K., Leggett, Cadman L., Ortiz-Fernández-Sordo, Jacobo, Ragunath, Krish, DiPietro, Massimiliano, Pech, Oliver, Neuhaus, Horst, and Bergman, Jacques J.

Published
2018
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44. Estudio Internacional y Multicéntrico WESTEROS: Resultados de la disección endoscópica submucosa circunferencial para el tratamiento del carcinoma escamoso esofágico precoz.

Author

Rodríguez, Enrique, primary, Van Tillburg, Laurelle, additional, Deprez, Pierre, additional, Pioche, Mathieu, additional, Pouw, Roos, additional, Bourke, Michael, additional, Seewald, Stefan, additional, Weusten, Bas, additional, Jacques, Jeremie, additional, Leblanc, Sarah, additional, Barreiro, Pedro, additional, Lemmers, Anaud, additional, Parra Blanco, Adolfo, additional, Küttner Magalhães, Ricardo, additional, Messmann, Helmut, additional, Albéniz, Eduardo, additional, Kaminski, Michal, additional, Mohameed, Noor, additional, Ramos Zabala, Felipe, additional, Herreros de Tejada, Alberto, additional, De Frutos, Diego, additional, Santiago, José, additional, Peñas García, Beatriz, additional, Parejo Carbonell, Sofía, additional, Uchima, Hugo, additional, Wallenhorst, Timothee, additional, Santos-Antunes, Joao, additional, Cunha Neves, Joao A., additional, Garces Duran, Rodrigo, additional, Ponchon, Thierry, additional, Bergman, Jacques, additional, White, Jonathan, additional, Muñoz Gonzalez, Raquel, additional, Libânio, Diogo, additional, and Dinis Ribeiro, Mario, additional

Published
2023
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45. COMPUTER-AIDED DIAGNOSIS (CADX) IMPROVES CHARACTERIZATION OF BARRETT’S NEOPLASIA BY ENDOSCOPISTS

Author

Jukema, Jelmer, primary, Kusters, Koen, additional, Jong, Martijn, additional, Fockens, Kiki, additional, Boers, Tim, additional, Van Der Putten, Joost, additional, Pouw, Roos, additional, Duits, Lucas, additional, Weusten, Bas, additional, Herrero, L. Alvarez, additional, Houben, Martin, additional, Nagengast, Wouter, additional, Westerhof, Jessie, additional, Alkhalaf, A., additional, Mallant-Hent, Rosalie, additional, Scholten, Pieter, additional, Ragunath, Krish, additional, Seewald, Stefan, additional, Elbe, Peter, additional, Baldaque-Silva, Francisco, additional, Barret, Maximilien, additional, Fernández-Sordo, Jacobo Ortiz, additional, Villarejo, Guiomar Moral, additional, Pech, Oliver, additional, Beyna, Torsten, additional, Van Der Sommen, Fons, additional, De With, P.H.N., additional, De Groof, Jeroen, additional, and Bergman, Jacques, additional

Published
2023
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46. VIDEO-BASED COMPUTER AIDED DETECTION SYSTEM IMPROVES BARRETT’S NEOPLASIA DETECTION OF GENERAL ENDOSCOPISTS IN A MULTI-STEP BENCHMARKING STUDY

Author

Jong, Martijn, primary, Fockens, Kiki, additional, Jukema, Jelmer, additional, Boers, Tim, additional, Kusters, Koen, additional, Van Der Putten, Joost, additional, Pouw, Roos, additional, Duits, Lucas, additional, Weusten, Bas, additional, Herrero, L. Alvarez, additional, Houben, Martin, additional, Nagengast, Wouter, additional, Westerhof, Jessie, additional, Alkhalaf, A., additional, Mallant-Hent, Rosalie, additional, Scholten, Pieter, additional, Ragunath, Krish, additional, Seewald, Stefan, additional, Elbe, Peter, additional, Baldaque-Silva, Francisco, additional, Barret, Maximilien, additional, Fernández-Sordo, Jacobo Ortiz, additional, Villarejo, Guiomar Moral, additional, Pech, Oliver, additional, Beyna, Torsten, additional, Van Der Sommen, Fons, additional, De With, P.H.N., additional, De Groof, Jeroen, additional, and Bergman, Jacques, additional

Published
2023
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48. Tu1281 VALIDATION OF THE CHARLSON COMORBIDITY INDEX FOR PREDICTION OF MORTALITY CAUSED BY OTHER CAUSES THAN ESOPHAGEAL ADENOCARCINOMA AFTER SUCCESSFUL ENDOSCOPIC ERADICATION THERAPY FOR BARRETT'S NEOPLASIA.

Author

Verheij, Eva P., primary, Van Munster, Sanne, additional, Cotton, Cary C., additional, Özdemir, Özge, additional, Toes-Zoutendijk, Esther, additional, Nieuwenhuis, Esther, additional, Lansdorp-Vogelaar, Iris, additional, Weusten, Bas L., additional, Herrero, L. Alvarez, additional, Alkhalaf, A., additional, Schenk, B., additional, Schoon, Erik J., additional, Curvers, Wouter, additional, Koch, Arjun D., additional, De Jonge, P.J.F., additional, Tang, Thjon J., additional, Nagengast, Wouter B., additional, Westerhof, Jessie, additional, Houben, Martin H., additional, Shaheen, Nicholas J., additional, Bergman, Jacques, additional, and Pouw, Roos E., additional

Published
2023
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