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7. Die Sequenzvarianten Arg72Pro des Tumorsuppressorgens p53 und Arg462Gln des Prostatakarzinom-Suszeptibilitätsgens RNASEL haben einen additiven Effekt auf das Erkrankungsalter von HNPCC-Patienten

Author

Deutsches HNPCC-Konsortium, Krüger, Stefan, Engel, C., Bier, A., Silber, A. -S., Görgens, H., Mangold, E., Pagenstecher, C., Holinski-Feder, E., von Knebel Doeberitz, M., Royer-Pokora, B., Dechant, S., Pox, C., Rahner, N., Müller, A., Schackert, H. K., Steinau, H. -U., editor, Schackert, H. K., editor, and Bauer, H., editor

Published
2007
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27. European guidelines for quality assurance in colorectal cancer screening and diagnosis: overview and introduction to the full supplement publication

Author

Von Karsa, L, Patnick, J, Segnan, N, Atkin, W, Halloran, S, Lansdorp Vogelaar, I, Malila, N, Minozzi, S, Moss, S, Quirke, P, Steele, Rj, Vieth, M, Aabakken, L, Altenhofen, L, Ancelle Park, R, Antoljak, N, Anttila, A, Armaroli, P, Arrossi, S, Austoker, J, Banzi, R, Bellisario, C, Blom, J, Brenner, H, Bretthauer, M, Camargo Cancela, M, Costamagna, Guido, Cuzick, J, Dai, M, Daniel, J, Dekker, E, Delicata, N, Ducarroz, S, Erfkamp, H, Espinàs, Ja, Faivre, J, Faulds Wood, L, Flugelman, A, Frkovic Grazio, S, Geller, B, Giordano, L, Grazzini, G, Green, J, Hamashima, C, Herrmann, C, Hewitson, P, Hoff, G, Holten, I, Jover, R, Kaminski, Mf, Kuipers, Ej, Kurtinaitis, J, Lambert, R, Launoy, G, Lee, W, Leicester, R, Leja, M, Lieberman, D, Lignini, T, Lucas, E, Lynge, E, Mádai, S, Marinho, J, Maučec Zakotnik, J, Minoli, G, Monk, C, Morais, A, Muwonge, R, Nadel, M, Neamtiu, L, Peris Tuser, M, Pignone, M, Pox, C, Primic Zakelj, M, Psaila, J, Rabeneck, L, Ransohoff, D, Rasmussen, M, Regula, J, Ren, J, Rennert, G, Rey, J, Riddell, Rh, Risio, M, Rodrigues, V, Saito, H, Sauvaget, C, Scharpantgen, A, Schmiegel, W, Senore, C, Siddiqi, M, Sighoko, D, Smith, R, Smith, S, Suchanek, S, Suonio, E, Tong, W, Törnberg, S, Villain, P, Van Cutsem, E., Costamagna, Guido (ORCID:0000-0002-8100-2731), Von Karsa, L, Patnick, J, Segnan, N, Atkin, W, Halloran, S, Lansdorp Vogelaar, I, Malila, N, Minozzi, S, Moss, S, Quirke, P, Steele, Rj, Vieth, M, Aabakken, L, Altenhofen, L, Ancelle Park, R, Antoljak, N, Anttila, A, Armaroli, P, Arrossi, S, Austoker, J, Banzi, R, Bellisario, C, Blom, J, Brenner, H, Bretthauer, M, Camargo Cancela, M, Costamagna, Guido, Cuzick, J, Dai, M, Daniel, J, Dekker, E, Delicata, N, Ducarroz, S, Erfkamp, H, Espinàs, Ja, Faivre, J, Faulds Wood, L, Flugelman, A, Frkovic Grazio, S, Geller, B, Giordano, L, Grazzini, G, Green, J, Hamashima, C, Herrmann, C, Hewitson, P, Hoff, G, Holten, I, Jover, R, Kaminski, Mf, Kuipers, Ej, Kurtinaitis, J, Lambert, R, Launoy, G, Lee, W, Leicester, R, Leja, M, Lieberman, D, Lignini, T, Lucas, E, Lynge, E, Mádai, S, Marinho, J, Maučec Zakotnik, J, Minoli, G, Monk, C, Morais, A, Muwonge, R, Nadel, M, Neamtiu, L, Peris Tuser, M, Pignone, M, Pox, C, Primic Zakelj, M, Psaila, J, Rabeneck, L, Ransohoff, D, Rasmussen, M, Regula, J, Ren, J, Rennert, G, Rey, J, Riddell, Rh, Risio, M, Rodrigues, V, Saito, H, Sauvaget, C, Scharpantgen, A, Schmiegel, W, Senore, C, Siddiqi, M, Sighoko, D, Smith, R, Smith, S, Suchanek, S, Suonio, E, Tong, W, Törnberg, S, Villain, P, Van Cutsem, E., and Costamagna, Guido (ORCID:0000-0002-8100-2731)

Abstract

Population-based screening for early detection and treatment of colorectal cancer (CRC) and precursor lesions, using evidence-based methods, can be effective in populations with a significant burden of the disease provided the services are of high quality. Multidisciplinary, evidence-based guidelines for quality assurance in CRC screening and diagnosis have been developed by experts in a project co-financed by the European Union. The 450-page guidelines were published in book format by the European Commission in 2010. They include 10 chapters and over 250 recommendations, individually graded according to the strength of the recommendation and the supporting evidence. Adoption of the recommendations can improve and maintain the quality and effectiveness of an entire screening process, including identification and invitation of the target population, diagnosis and management of the disease and appropriate surveillance in people with detected lesions. To make the principles, recommendations and standards in the guidelines known to a wider professional and scientific community and to facilitate their use in the scientific literature, the original content is presented in journal format in an open-access Supplement of Endoscopy. The editors have prepared the present overview to inform readers of the comprehensive scope and content of the guidelines.

Published
2013

28. European guidelines for quality assurance in colorectal cancer screening and diagnosis: Overview and introduction to the full Supplement publication

Author

Von Karsa, L., Patnick, J., Segnan, N., Atkin, W., Halloran, S., Lansdorp_Vogelaar, Iris, Malila, N., Minozzi, S., Moss, S., Quirke, P., Steele, R., Vieth, M., Aabakken, L., Altenhofen, L., Ancelle-Park, R., Antoljak, N., Anttila, A., Armaroli, P., Arrossi, S., Austoker, J., Banzi, R., Bellisario, C., Blom, J., Brenner, H., Bretthauer, M., Cancela, M., Costamagna, G., Cuzick, J., Dai, M., Daniel, J., Dekker, E., Delicata, N., Ducarroz, S., Erfkamp, H., Espinàs, J., Faivre, J., Wood, L., Flugelman, A., Frkovic-Grazio, S., Geller, B., Giordano, L., Grazzini, G., Green, J., Hamashima, C., Herrmann, C., Hewitson, P., Hoff, G., Holten, I., Jover, R., Kaminski, M., Kuipers, E., Kurtinaitis, J., Lambert, R., Launoy, G., Lee, W., Leicester, R., Leja, M., Lieberman, D., Lignini, T., Lucas, E., Lynge, E., Mádai, S., Marinho, J., Zakotnik, J., Minoli, G., Monk, C., Morais, A., Muwonge, R., Nadel, M., Neamtiu, L., Tuser, M., Pignone, M., Pox, C., Primic-Zakelj, M., Psaila, J., Rabeneck, L., Ransohoff, D., Rasmussen, M., Regula, J., Ren, J., Rennert, G., Rey, J., Riddell, R., Risio, M., Rodrigues, V., Saito, H., Sauvaget, C., Scharpantgen, A., Schmiegel, W., Senore, C., Siddiqi, M., Sighoko, D., Von Karsa, L., Patnick, J., Segnan, N., Atkin, W., Halloran, S., Lansdorp_Vogelaar, Iris, Malila, N., Minozzi, S., Moss, S., Quirke, P., Steele, R., Vieth, M., Aabakken, L., Altenhofen, L., Ancelle-Park, R., Antoljak, N., Anttila, A., Armaroli, P., Arrossi, S., Austoker, J., Banzi, R., Bellisario, C., Blom, J., Brenner, H., Bretthauer, M., Cancela, M., Costamagna, G., Cuzick, J., Dai, M., Daniel, J., Dekker, E., Delicata, N., Ducarroz, S., Erfkamp, H., Espinàs, J., Faivre, J., Wood, L., Flugelman, A., Frkovic-Grazio, S., Geller, B., Giordano, L., Grazzini, G., Green, J., Hamashima, C., Herrmann, C., Hewitson, P., Hoff, G., Holten, I., Jover, R., Kaminski, M., Kuipers, E., Kurtinaitis, J., Lambert, R., Launoy, G., Lee, W., Leicester, R., Leja, M., Lieberman, D., Lignini, T., Lucas, E., Lynge, E., Mádai, S., Marinho, J., Zakotnik, J., Minoli, G., Monk, C., Morais, A., Muwonge, R., Nadel, M., Neamtiu, L., Tuser, M., Pignone, M., Pox, C., Primic-Zakelj, M., Psaila, J., Rabeneck, L., Ransohoff, D., Rasmussen, M., Regula, J., Ren, J., Rennert, G., Rey, J., Riddell, R., Risio, M., Rodrigues, V., Saito, H., Sauvaget, C., Scharpantgen, A., Schmiegel, W., Senore, C., Siddiqi, M., and Sighoko, D.

Abstract

Population-based screening for early detection and treatment of colorectal cancer (CRC) and precursor lesions, using evidence-based methods, can be effective in populations with a significant burden of the disease provided the services are of high quality. Multidisciplinary, evidence-based guidelines for quality assurance in CRC screening and diagnosis have been developed by experts in a project co-financed by the European Union. The 450-page guidelines were published in book format by the European Commission in 2010.They include 10 chapters and over 250 recommendations, individually graded according to the strength of the recommendation and the supporting evidence. Adoption of the recommendations can improve and maintain the quality and effectiveness of an entire screening process, including identification and invitation of the target population, diagnosis and management of the disease and appropriate surveillance in people with detected lesions. To make the principles, recommendations and standards in the guidelines known to a wider professional and scientific community and to facilitate their use in the scientific literature, the original content is presented in journal format in an open-access Supplement of Endoscopy. The editors have prepared the present overview to inform readers of the comprehensive scope and content of the guidelines. © Georg Thieme Verlag KG Stuttgart · New York.

Published
2013

30. S3-Leitlinie Kolorektales Karzinom Version 1.0 - Juni 2013 AWMF-Registernummer: 021/007OL

Author

Pox, C., additional, Aretz, S., additional, Bischoff, S., additional, Graeven, U., additional, Hass, M., additional, Heußner, P., additional, Hohenberger, W., additional, Holstege, A., additional, Hübner, J., additional, Kolligs, F., additional, Kreis, M., additional, Lux, P., additional, Ockenga, J., additional, Porschen, R., additional, Post, S., additional, Rahner, N., additional, Reinacher-Schick, A., additional, Riemann, J., additional, Sauer, R., additional, Sieg, A., additional, Scheppach, W., additional, Schmitt, W., additional, Schmoll, H., additional, Schulmann, K., additional, Tannapfel, A., additional, and Schmiegel, W., additional

Published
2013
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33. alpha-Glucosidase inhibition (acarbose) fails to enhance secretion of glucagon-like peptide 1 (7-36 amide) and to delay gastric emptying in Type 2 diabetic patients

Author

Hücking, K, Kostic, Z, Pox, C, Ritzel, R, Holst, Jens Juul, Schmiegel, W, Nauck, M A, Hücking, K, Kostic, Z, Pox, C, Ritzel, R, Holst, Jens Juul, Schmiegel, W, and Nauck, M A

Abstract

AIM: Acarbose is able to enhance GLP-1 release and delay gastric emptying in normal subjects. The effect of alpha-glucosidase inhibition on GLP-1 has been less evident in Type 2 diabetic patients. The aim of this study was to investigate the possible influence of acarbose on GLP-1 release and gastric emptying in Type 2 diabetic patients after a mixed test meal.PATIENTS AND METHODS: Ten Type 2 diabetic patients were tested with 100 mg acarbose or placebo served with a mixed meal that was labelled with 100 mg 13C-octanoic acid. Plasma concentrations of glucose, insulin, C-peptide, glucagon, GLP-1 and GIP were determined over 6 h. Gastric emptying was measured by determining breath 13CO2 using infrared absorptiometry. Statistics repeated-measures anova.RESULTS: Gastric emptying rates (t1/2: 162 +/- 45 vs. 163 +/- 62 min, P = 0.65) and plasma concentrations (increasing from approximately 12 to approximately 25 pmol/l, P = 0.37) and integrated responses of GLP-1 (P = 0.37) were not changed significantly by acarbose treatment. Postprandial plasma glucose concentrations (P < 0.0001) and their integrated responses were lowered by acarbose (by 64%; P = 0.016). The plasma concentrations of insulin and C-peptide were reduced (P = 0.007 and 0.057, respectively) by acarbose, while glucagon was not changed (P = 0.96). GIP plasma concentrations (increasing with placebo from approximately 10 to approximately 85 pmol/l and with acarbose to approximately 55 pmol/l (P < 0.0001) and their integrated responses were significantly lowered (by 43%) by acarbose (P = 0.021). After 2 weeks of acarbose treatment (50 mg t.i.d. for the first and 100 mg t.i.d. for the second week, n = 6), similar results were found.CONCLUSIONS: In hyperglycaemic Type 2 diabetic patients, ingestion of acarbose with a mixed test meal failed to enhance GLP-1 release and did not influence gastric emptying.

Published
2005

40. Eine kapnographische Überwachung erhöht die Sicherheit einer Propofol Sedierung während Koloskopie: Eine randomisierte, kontrollierte, trizentrische Studie (ColoCap Study)

Author

Beitz, A, primary, Riphaus, A, additional, Meining, A, additional, Kronshage, T, additional, Geist, C, additional, Wagenpfeil, S, additional, Weber, A, additional, Jung, A, additional, Bajbouj, M, additional, Pox, C, additional, Schneider, G, additional, Schmid, RM, additional, Wehrmann, T, additional, and Delius, S von, additional

Published
2011
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44. S3 Guidelines for Colorectal Carcinoma

Author

Schmiegel, W., primary, Pox, C., additional, Reinacher-Schick, A., additional, Adler, G., additional, Arnold, D., additional, Fleig, W., additional, Fölsch, U., additional, Frühmorgen, P., additional, Graeven, U., additional, Heinemann, V., additional, Hohenberger, W., additional, Holstege, A., additional, Junginger, T., additional, Kopp, I., additional, Kühlbacher, T., additional, Porschen, R., additional, Propping, P., additional, Riemann, J.-F., additional, Rödel, C., additional, Sauer, R., additional, Sauerbruch, T., additional, Schmitt, W., additional, Schmoll, H.-J., additional, Seufferlein, T., additional, Zeitz, M., additional, and Selbmann, H.-K., additional

Published
2010
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48. S3-Leitlinie „Kolorektales Karzinom” – Aktualisierung 2008

Author

Schmiegel, W, primary, Reinacher-Schick, A, additional, Arnold, D, additional, Graeven, U, additional, Heinemann, V, additional, Porschen, R, additional, Riemann, J, additional, Rödel, C, additional, Sauer, R, additional, Wieser, M, additional, Schmitt, W, additional, Schmoll, H.-J, additional, Seufferlein, T, additional, Kopp, I, additional, and Pox, C, additional

Published
2008
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