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1. Design and development of the magnetic diagnostic systems for the first operational phase of the SMART tokamak.

Author

Pozo, F. Puentes-del, Vicente-Torres, P., Cruz-Zabala, D. J., Munaretto, S., Garcia-Munoz, M., Viezzer, E., Mancini, A., Rodriguez-Gonzalez, A., Sanchez-Gamino, J., and Segado-Fernandez, J.

Subjects
*DATA acquisition systems, *PLASMA instabilities, *POSITION sensors, *MAGNETIC flux, *PLASMA currents
Abstract

A set of magnetic diagnostics has been designed, manufactured, and calibrated for the first operational phase of the small aspect ratio tokamak. The sensor suite comprises of Rogowski coils; 2D magnetic probes; and poloidal, saddle, and diamagnetic flux loops. A set of continuous Rogowski coils has been manufactured for the measurement of plasma current and induced eddy currents in conductive elements. A set of flux loops and magnetic probes will be used as input for the reconstruction of the magnetohydrodynamic equilibrium. The quantity and position of these sensors have been verified to be sufficient with synthetic equilibrium reconstructions using the equilibrium fitting code and baseline scenarios computed with the Fiesta code. These sensors will also be used as input for the real-time control system, and magnetic probes will be used for the detection of plasma instabilities. The calibration procedure for the magnetic probes is described, and the results are shown. The signal conditioning and data acquisition systems are described. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Impact of Prematurity and Severe Viral Bronchiolitis on Asthma Development at 6–9 Years

Author

Garcia-Garcia ML, Gonzalez-Carrasco E, Bracamonte T, Molinero M, Pozo F, Casas I, and Calvo C

Subjects
asthma, wheezing, prematurity, bronchiolitis, rhinovirus, respiratory syncytial virus, Immunologic diseases. Allergy, RC581-607
Abstract

Maria Luz Garcia-Garcia,1 Ersilia Gonzalez-Carrasco,2 Teresa Bracamonte,1 Mar Molinero,3 Francisco Pozo,3 Inmaculada Casas,3 Cristina Calvo4 1Pediatrics Department, Severo Ochoa University Hospital, Fundación IDIPHISA, Alfonso X El Sabio University Madrid, Spain. Translational Research Network in Pediatric Infectious Diseases (RITIP), Madrid, Spain; 2Department, Severo Ochoa University Hospital, Fundación IDIPHISA. Alfonso X El Sabio University, Madrid, Spain; 3Respiratory Virus and Influenza Unit, National Microbiology Center (ISCIII), Madrid, Spain; 4Pediatric Infectious Diseases Department, Fundación IdiPaz, Translational Research Network in Pediatric Infectious Diseases (RITIP), Madrid, Spain. TEDDY Network (European Network of Excellence for Pediatric Clinical Research), Italy. La Paz University Hospital, Madrid, SpainCorrespondence: Maria Luz Garcia-Garcia Email marialuz.hso@gmail.comBackground: Premature birth is associated with increased susceptibility for viral infections and chronic airway morbidity. Preterm children, even moderate and late, may be at risk for short- and long-term respiratory morbidities.Objective: Our main goal was to compare the burden of two conditions, severe bronchiolitis and prematurity (early and moderate-late), on asthma development at 6– 9 years.Patients and Methods: A retrospective cohort of all preterm (< 37weeks gestational age) and full-term children hospitalized for bronchiolitis, with current age between 6 and 9 years, was created. A second cohort was made up of preterm children, without admission for bronchiolitis, randomly chosen from the hospital premature births database. Prevalence and risk factors for asthma were analysed. Parents completed the International Study of Asthma and Allergies in Childhood (ISAAC) Questionnaire for asthma symptoms for children 6– 7 years. Lung function and aeroallergen sensitization were evaluated.Results: Of the 480 selected children, 399 could be contacted and agreed to participate: 133 preterm and 114 full-term cases with admission for bronchiolitis and 146 preterm control children without admission for bronchiolitis. The frequency of current asthma at 6– 9 years was higher in preterm cases (27%) compared with full-term-cases (15%) and preterm controls (14%) (p=0.04). Among hospitalized-bronchiolitis children, prematurity (p=0.04), rhinovirus infection (p=0.03), viral coinfection (p=0.04) and paternal asthma (p=0.003) were risk factors for asthma at 6– 9 years. Among premature children, with and without bronchiolitis admission, the risk factors for asthma at 6– 9 years were admission for bronchiolitis (p=0.03) and aeroallergen sensitisation (p=0.01). Moderate and late preterm children without admission for bronchiolitis showed similar prevalence of current asthma than full-term ones, previously admitted for bronchiolitis.Conclusion: Preterm birth is an important early life risk factor for asthma in childhood. The addition of other risk factors, such as severe bronchiolitis, especially by rhinovirus or viral coinfections, are associated with even higher risk for subsequent asthma.Keywords: asthma, wheezing, prematurity, bronchiolitis, rhinovirus, respiratory syncytial virus

Published
2020

6. Functional Hubs in Mild Cognitive Impairment

Author

Navas, Adrián, Papo, David, Boccaletti, Stefano, del-Pozo, F., Bajo, Ricardo, Maestú, Fernando, Gil, Pedro, Sendiña-Nadal, Irene, and Buldú, Javier M.

Subjects
Quantitative Biology - Neurons and Cognition
Abstract

We investigate how hubs of functional brain networks are modified as a result of mild cognitive impairment (MCI), a condition causing a slight but noticeable decline in cognitive abilities, which sometimes precedes the onset of Alzheimer's disease. We used magnetoencephalography (MEG) to investigate the functional brain networks of a group of patients suffering from MCI and a control group of healthy subjects, during the execution of a short-term memory task. Couplings between brain sites were evaluated using synchronization likelihood, from which a network of functional interdependencies was constructed and the centrality, i.e. importance, of their nodes quantified. The results showed that, with respect to healthy controls, MCI patients were associated with decreases and increases in hub centrality respectively in occipital and central scalp regions, supporting the hypothesis that MCI modifies functional brain network topology, leading to more random structures., Comment: 12 pages, 5 figures, to appear in International Journal of Bifurcations and Chaos, 2013

Published
2013

7. Topological Measure Locating the Effective Crossover between Segregation and Integration in a Modular Network

Author

Rad, A. Ajdari, Sendiña-Nadal, I., Papo, D., Zanin, M., Buldú, J. M., del Pozo, F., and Boccaletti, S.

Subjects
Nonlinear Sciences - Adaptation and Self-Organizing Systems, Condensed Matter - Statistical Mechanics, Physics - Biological Physics, Physics - Physics and Society
Abstract

We introduce an easily computable topological measure which locates the effective crossover between segregation and integration in a modular network. Segregation corresponds to the degree of network modularity, while integration is expressed in terms of the algebraic connectivity of an associated hyper-graph. The rigorous treatment of the simplified case of cliques of equal size that are gradually rewired until they become completely merged, allows us to show that this topological crossover can be made to coincide with a dynamical crossover from cluster to global synchronization of a system of coupled phase oscillators. The dynamical crossover is signaled by a peak in the product of the measures of intra-cluster and global synchronization, which we propose as a dynamical measure of complexity. This quantity is much easier to compute than the entropy (of the average frequencies of the oscillators), and displays a behavior which closely mimics that of the dynamical complexity index based on the latter. The proposed toplogical measure simultaneously provides information on the dynamical behavior, sheds light on the interplay between modularity vs total integration and shows how this affects the capability of the network to perform both local and distributed dynamical tasks.

Published
2012
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8. Formation of asteroid pairs by rotational fission

Author

Pravec, P., Vokrouhlicky, D., Polishook, D., Scheeres, D. J., Harris, A. W., Galad, A., Vaduvescu, O., Pozo, F., Barr, A., Longa, P., Vachier, F., Colas, F., Pray, D. P., Pollock, J., Reichart, D., Ivarsen, K., Haislip, J., LaCluyze, A., Kusnirak, P., Henych, T., Marchis, F., Macomber, B., Jacobson, S. A., Krugly, Yu. N., Sergeev, A. V., and Leroy, A.

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

Asteroid pairs sharing similar heliocentric orbits were found recently. Backward integrations of their orbits indicated that they separated gently with low relative velocities, but did not provide additional insight into their formation mechanism. A previously hypothesized rotational fission process4 may explain their formation - critical predictions are that the mass ratios are less than about 0.2 and, as the mass ratio approaches this upper limit, the spin period of the larger body becomes long. Here we report photometric observations of a sample of asteroid pairs revealing that primaries of pairs with mass ratios much less than 0.2 rotate rapidly, near their critical fission frequency. As the mass ratio approaches 0.2, the primary period grows long. This occurs as the total energy of the system approaches zero requiring the asteroid pair to extract an increasing fraction of energy from the primary's spin in order to escape. We do not find asteroid pairs with mass ratios larger than 0.2. Rotationally fissioned systems beyond this limit have insufficient energy to disrupt. We conclude that asteroid pairs are formed by the rotational fission of a parent asteroid into a proto-binary system which subsequently disrupts under its own internal system dynamics soon after formation., Comment: 12 pages, 2 figures, 1 table + Supplementary Information

Published
2010
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29. Endometriosis umbilical secundaria: Presentación de dos casos y revisión bibliográfica

Author

Serrano Borrero, Isabelo, Roldán-Aviña, Juan Pastor, Merlo Molina, S., Bonilla De los Santos, I., Muñoz Pozo, F., Serrano Borrero, Isabelo, Roldán-Aviña, Juan Pastor, Merlo Molina, S., Bonilla De los Santos, I., and Muñoz Pozo, F.

Abstract

Introduction: cases of umbilical endometriosis reported after gynecological laparoscopic surgery are rare, and sometimes they become a real diagnostic challenge. Clinical cases:we present two cases of patients with a history of gynecological laparoscopy (ovarian endometrioma and ovarian teratoma, respectively) that years later presented painful nodules secondary to an endometrial implant at the umbilicus. Discussion: it is necessary to distinguish between primary umbilical endometriosis (Villar's nodule) and those cases due to implants from surgical procedures. A high level of suspicion should be maintained in these types of patients. Surgical excision with wide margins is the technical choice, and the simultaneous performance of a laparoscopy is debated. Prophylaxis by removing the surgical piece into a bag is recommended., Introducción: los casos de endometriosis umbilical reportados tras cirugía laparoscópica ginecológica son raros, y en ocasiones suponen un auténtico reto diagnóstico. Casos clínicos: presentamos dos casos de pacientes con antecedentes de laparoscopia ginecológica (endometrioma ovárico y teratoma ovárico respectivamente) que años después presentaron a nivel umbilical un nódulo doloroso secundario a implante endometrial. Discusión: hay que distinguir entre la endometriosis umbilical primaria (nódulo de Villar) y la secundaria a implantes por procedimientos quirúrgicos. Se debe mantener un alto nivel de sospecha en este tipo de pacientes. La exéresis quirúrgica con márgenes amplios es de elección, debatiéndose la realización simultánea de una laparoscopia. Se recomienda la profilaxis mediante la extracción de la pieza operatoria en una bolsa.

Published
2022

30. Torsión testicular en un paciente anciano con criptorquidia simulando hernia inguinal incarcerada

Author

Roldán-Aviña, Juan Pastor, Serrano Borrero, Isabelo, Merlo Molina, S., Muñoz Pozo, F., Pastrana Gallego, E., Roldán-Aviña, Juan Pastor, Serrano Borrero, Isabelo, Merlo Molina, S., Muñoz Pozo, F., and Pastrana Gallego, E.

Abstract

Introduction: cryptorchidism in elderly patients is extremely rare and can be confused with a complicated inguinal hernia. Clinical case: a 96-year-old man who came to the emergency room for intense left groin pain with an irreducible tumor at that level that was classified as an episode of incarceration. After the physical examination, it was found that the left hemiscrotum was empty, confirming by Doppler ultrasound that it was a left cryptorchidism that had presented an episode of testicular torsion. Discussion: there is little bibliography on acute complications in adult patients with cryptorchidism. In the case of torsion of the undescended testicle, it can easily be confused with an incarcerated inguinal hernia. In some cases it can be diagnosed with a Doppler ultrasound, although in most cases it will be an intraoperative finding., Introducción: la criptorquidia en pacientes ancianos es extremadamente rara y puede confundirse con una hernia inguinal complicada. Caso clínico: varón de 96 años que acudió a Urgencias por dolor inguinal izquierdo intenso con una tumoración irreductible a dicho nivel que se catalogó con episodio de incarceración. Tras la exploración física se constató que el hemiescroto izquierdo estaba vacío confirmándose mediante ecografía-doppler que se trataba de una criptorquidia izquierda que había presentado un episodio de torsión testicular. Discusión: existe poca bibliografía sobre complicaciones agudas de pacientes adultos con criptorquidia. En caso de torsión del testículo no descendido puede confundirse fácilmente con una hernia inguinal incarcerada. En algunos casos se podrá diagnosticar con una ecografía-doppler, aunque en la mayoría de las ocasiones será un hallazgo intraoperatorio.

Published
2022

37. 1287P Immune T-cell subpopulations from the peripheral blood of non-small cell lung cancer patients are associated with the efficacy of anti-PD-1 immunotherapy

Author

Rogado, J., primary, Pozo, F., additional, Troulè, K., additional, Sánchez-Torres, J.M., additional, Laorden, N. Romero, additional, Solís, R. Mondéjar, additional, Candil, O. Donnay, additional, García, A.I. Ballesteros, additional, Pacheco-Barcia, V., additional, Aspa, J., additional, Al-Shahrour, F., additional, Alfranca, A., additional, and Colomer, R., additional

Published
2021
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41. Inguinodinia aguda postapendicectomía

Author

Roldán-Aviña, Juan Pastor, Merlo Molina, S., Serrano Borrero, Isabelo, Díaz Brito, Jack Antonio, Muñoz Pozo, F., Roldán-Aviña, Juan Pastor, Merlo Molina, S., Serrano Borrero, Isabelo, Díaz Brito, Jack Antonio, and Muñoz Pozo, F.

Abstract

Among the complications of appendectomy we can find postoperative pain, usually related to local problems of the operating wound or longer term with the development of an inguinal hernia. We present a case of an appendicitis intervened patient who developed acute pain at the right groin without local complications or evidence of inguinal hernia or other intraabdominal pathology in imaging tests., Entre las complicaciones de la apendicectomía podemos encontrar el dolor postoperatorio que habitualmente se relaciona con problemas locales de la herida operatoria o a más largo plazo con el desarrollo de una hernia inguinal. Presentamos un caso de un paciente apendicectomizado que presentó un dolor agudo a nivel inguinal derecho sin complicaciones locales ni evidencia de hernia u otra patología intraabdominal en las pruebas de imagen.

Published
2021

43. Predictive factors of severe multilobar pneumonia and shock in patients with influenza

Author

Garcia Gutierrez, Susana, Quintana, José Maria, Baricot, Maretva, Bilbao, Amaia, Capelastegui, Alberto, Cilla Eguiluz, Carlos Gustavo, Domínguez, Angela, Castilla, Jesús, Godoy, Pere, Delgado-Rodríguez, Miguel, Soldevila, Núria, Astray, Jenaro, Mayoral, José María, Martín, Vicente, González-Candelas, Fernando, Galán, Juan Carlos, Tamames, Sonia, Castro-Acosta, Ady Angélica, Garín, Olatz, Pumarola, Tomás, Bueno, M A, Gómez, M L, Mariscal, M, Martínez, B, Quesada, J P, Sillero, M, Carnero, M, Fernández-Crehuet, J, del Diego Salas, J, Fuentes, V, Gallardo, V, Pérez, E, López, R, Maldonado, J R, Morillo, A, Pedrosa Corral, I, Bautista, MF, Navarro, JM, Pérez, M, Oña, S, Pérez, MJ, Ubago, MC, Zarzuela, M, Sanz, P, Carriedo, D, Díez, F, Fernández, I, Fernández, S, Sanz, M P, Castrodeza, J J, Pérez, A, Ortiz de Lejarazu, R, Ortiz, J, Pueyo, A, Viejo, J L, Seco, A, Redondo, P, Molina, A, Agustí, A, Torres, A, Trilla, A, Vilella, A, Barbé, F, Blanch, L, Navarro, G, Bonfill, X, López-Contreras, J, Pomar, V, Puig, M T, Borràs, E, Martínez, A, Torner, N, Bravo, C, Moraga, F, Calafell, F, Caylà, J, Tortajada, C, Garcia, I, Ruiz, J, García, J J, Alonso, J, Gea, J, Horcajada, J P, Hayes, N, Rosell, A, Dorca, J, Saez, Marc, Álvarez, C, Enríquez, M, Pozo, F, Baquero, F, Cantón, R, Robustillo, A, Valdeón, M, Córdoba, E, Domínguez, F, García, J, Génova, R, Gil, E, Jiménez, S, Lopaz, M A, López, J, Martín, F, Martínez, M L, Ordobás, M, Rodriguez, E, Sánchez, S, Valdés, C, Paño, J R, Romero, M, Martínez, A, Martínez, L, Ruiz, M, Fanlo, P, Gil, F, Martínez-Artola, V, Quintana, J M, Aguirre, U, España, P P, García, S, Antoñana, J M, Astigarraga, I, Pijoan, J I, Pocheville, I, Santiago, M, Villate, J I, Arístegui, J, Escobar, A, Garrote, M I, Bilbao, A, Garaizar, C, Korta, J, Pérez-Trallero, E, Sarasqueta, C, Aizpuru, F, Lobo, J L, Salado, C, Alustiza, J, Troya, F J, Blanquer, J, and Morale, M

Published
2014
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47. Effectiveness of influenza vaccination during pregnancy to prevent severe infection in children under 6 months of age, Spain, 2017-2019

Author

Mazagatos C, Godoy P, Munoz-Almagro C, Pozo F, and Larrauri A

Subjects
Vaccine, virus diseases, Pregnancy, Screening, Influenza
Abstract

INTRODUCTION: Influenza vaccination is recommended to pregnant women in Spain to reduce the risk of influenza-related complications. Influenza related hospitalizations pose a significant disease burden in children every year. Although children below 6 months are too young to be vaccinated, they can receive protection against influenza through vaccination of their mothers during pregnancy. We estimated the effectiveness of maternal influenza vaccination to prevent influenza hospitalizations in infants under 6 months of age. METHODS: This is a retrospective pilot study, using data from the Severe Hospitalized Confirmed Influenza Cases (SHCIC) surveillance system in seasons 2017/18 and 2018/19 in Spain. Maternal vaccination status during pregnancy was collected for cases in children 6 months and younger hospitalized with confirmed influenza infection. Influenza vaccine effectiveness was estimated using the screening method, by comparing the proportion of children with vaccinated mothers during pregnancy (proportion of cases vaccinated, PCV), with the vaccination coverage among pregnant women in Spain (proportion of population vaccinated, PPV). RESULTS: For all the study period, the PCV was 17% and the PPV was 35%. Influenza vaccination in mothers during pregnancy prevented influenza confirmed hospitalizations in infants aged 6 months and younger with a 61% (95%CI: 27-79%) effectiveness. CONCLUSIONS: In line with evidence from other countries, influenza vaccination during pregnancy protects infants up to 6 months of age from influenza hospitalizations in Spain. These results support current recommendations of influenza vaccination in pregnant women, and more studies are needed in Spain to confirm the double protection of maternal vaccination in mothers and infants.

Published
2020

49. Apendicitis aguda diagnosticada durante una colonoscopia

Author

Roldán-Aviña, Juan Pastor, Merlo Molina, S., Muñoz Pozo, F., Herrera Gutiérrez, L., Díaz Brito, JA, Roldán-Aviña, Juan Pastor, Merlo Molina, S., Muñoz Pozo, F., Herrera Gutiérrez, L., and Díaz Brito, JA

Abstract

The diagnosis of acute appendicitis is made on a clinical basis and is supported by complementary studies (analytical and imaging tests). Diagnosis during colonoscopy is rare and is usually an incidental finding. We present a case of acute appendicitis diagnosed by colonoscopy performed to control adenomatous polyps., El diagnóstico de la apendicitis aguda es eminentemente clínico y se apoya en estudios complementarios (analíticas y pruebas de imagen), por lo que diagnosticarla durante la realización de una colonoscopia es extraordinariamente infrecuente. Presentamos un caso de apendicitis aguda diagnosticada por colonoscopia realizada durante el control de un paciente con pólipos adenomatosos.

Published
2020

50. Viral Infections of The Central Nervous System in Spain: A Prospective Study

Author

de Ory, F., Avellón, A., Echevarría, J. E., Sánchez-Seco, M. P., Trallero, G., Cabrerizo, M., Casas, I., Pozo, F., Fedele, G., Vicente, D., Pena, M. J., Moreno, A., Niubo, J., Rabella, N., Rubio, G., Pérez-Ruiz, M., Rodríguez-Iglesias, M., Gimeno, C., Eiros, J. M., Melón, S., Blasco, M., López-Miragaya, I., Varela, E., Martinez-Sapiña, A., Rodríguez, G., Marcos, M.Á., Gegúndez, M. I., Cilla, G., Gabilondo, I., Navarro, J. M., Torres, J., Aznar, C., Castellanos, A., Guisasola, M. E., Negredo, A. I., Tenorio, A., and Vázquez-Morón, S.

Published
2013
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