28 results on '"Prabhu, Arpan V."'
Search Results
2. Re-irradiation of recurrent head and neck cancers using pulsed reduced dose rate radiotherapy: An institutional series.
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Megahed, Romy, Prabhu, Arpan V., Mack, Delanie P., Gholami, Somayeh, Samanta, Santanu, Patel, Mausam, and Lewis, Gary D.
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HEAD & neck cancer , *RADIOTHERAPY , *PROGRESSION-free survival , *SQUAMOUS cell carcinoma , *OVERALL survival , *SURVIVAL rate , *CANCER patients - Abstract
• Many head/neck squamous cell cancer patients develop recurrence or second primary. • Re-irradiation is a curative treatment option for these patients. • However, it is associated with significant risk of toxicity. • Pulsed Reduced Dose Rate radiation may reduce re-irradiation toxicity. Pulsed reduced dose rate (PRDR) radiation (RT) is a re-irradiation (Re-RT) technique that potentially overcomes dose/volume constraints in the setting of previous RT. There is minimal data for its use for recurrent or secondary primary head and neck squamous cell carcinoma (HNSCC). In this study, we report preliminary data from our institution of a consecutive cohort of HNSCC patients who received PRDR Re-RT. Nine patients received PRDR Re-RT from August 2020 to January 2023 and had analyzable data. Intensity modulated RT was used for treatment delivery and a wait time between 20 cGy arc/helical deliveries was used to achieve the effective low dose rate. Data collected included patient demographic information, prior interventions, diagnosis, radiation therapy dose and fractionation, progression free survival, overall survival, and toxicity rates. The median time to PRDR-RT from completion of initial RT was 13 months (range, 6–50 months). All but one patient underwent salvage surgery prior to PRDR-RT. The median follow-up after Re-RT was 7 months. The median OS from PRDR-RT was 7 months (range, 1–32 months). Median PFS was 7 months (range, 1–32 months). One patient (11.1 %) had acute grade 3 toxicity, and two patients (22.2 %) had late grade 3 toxicities. There were no grade 4+ toxicities. PRDR Re-RT is a feasible treatment strategy for patients with recurrent or second primary HNSCC. Initial findings from this retrospective review suggest reasonable survival outcomes and potentially improved toxicity; prospective data is needed to establish the safety and efficacy of this technique. [ABSTRACT FROM AUTHOR]
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- 2024
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3. What are Ophthalmology Patients Asking Online? An Analysis of the Eye Triage Subreddit.
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Mahjoub, Heba, Prabhu, Arpan V, and Sikder, Shameema
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OPHTHALMOLOGY , *SURGICAL complications , *ANXIETY , *POSTAL codes , *OPHTHALMOLOGISTS - Abstract
background. Post and comment content codes were categorized in an iterative manner with differences resolved by author consensus. Categorical statistics were compiled. Results: Two hundred posts and 456 comments were analyzed since the creation of r/eyetriage, a forum created exclusively for patients to seek advice from health-care professionals. Twenty-six (13%) of the total posts included an image. On average, comments received 1.76 ± 2.17 upvotes along with 4.50 ± 4.47 replies. The most common content codes among the posts were 42 (21.0%) seeking diagnoses, 23 (11.5%) surgical complications, and 13 (6.50%) alternative medication options. Eighty-two (41%) posts conveyed a clear emotional tone, most notably 11 (13.4%) with anxiety and 10 (12.2%) with worry. The top comments came from 165 (36.2%) self-identified patients, 151 (33.1%) optometrists, and 49 (10.8%) ophthalmologists. The top comment codes for replies included 158 (34.7%) with treatment advice, 70 (15.4%) with advice deferred to follow-up appointment with other health-care specialists, and 60 (13.2%) with sharing information. Conclusions: Patients are asking ophthalmology-related questions on the Eye Triage subreddit, and they are more likely to receive information from other patients or optometrists than from self-identified ophthalmologists. When emotions were revealed, patients were often anxious and worried. Opportunities exist for ophthalmologists to take a more active role on this subreddit and help educate patients. [ABSTRACT FROM AUTHOR]
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- 2020
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4. Federal Political Contribution Characteristics of Radiation Oncologists in the United States from 2003 to 2018.
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Prabhu, Arpan V., Lehrer, Eric J., Clump II, David A., Kim, Thomas, and Clump, David A 2nd
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ELECTIONS , *LEGISLATION , *POLITICAL action committees , *POLITICAL parties , *ELECTION boards , *PRACTICAL politics - Abstract
Purpose: The health care industry has many stakeholders who seek relationships within government to ensure certain interests are considered in the legislative process. This study characterized the federal political contributions of US radiation oncologists (ROs).Methods and Materials: Public finance data from the Federal Election Commission (FEC) containing self-identified ROs' contributions to a federal candidate or committee were obtained from 2003 to 2018. Contribution recipients were classified as a political action committee (PAC) or a presidential, Senate, or House candidate. Political parties of recipients were based on FEC designations. For PACs, political parties of recipients were based on spending patterns to political parties in each 2-year election cycle or, when unavailable, overall spending patterns of greater than 50% to 1 political party, as detailed by the Center for Responsive Politics. Data were analyzed temporally, and Spearman's rho was used to assess trends.Results: From 2003 to 2018, the FEC reported a total of 31,646,000 federal political contributions. Exactly 4617 federal political contributions were made from 1021 unique self-identified ROs, totaling $3,350,747. The number of ROs making contributions ranged from 56 in 2005 to 600 in 2016 (mean, 289 ± 191.4 ROs yearly), with a mean annual contribution of $209,422. Of all RO dollars, 61.5% went to Democrats, 37.5% to Republicans, and 1.0% to third-party candidates. Most RO dollars (81.0%) went to PACs rather than candidates, with the majority of those PAC dollars (50.2%) directed toward the American Society for Radiation Oncology Political Action Committee. There was a positive annual trend in number of donors by year (ρ = 0.83, P < .0001) as well as RO contributions to the House (ρ = 0.58, P < .02), Senate (ρ = 0.58, P < .02), Democrats (ρ = 0.81, P < .001), Republicans (ρ = 0.66, P < .006), third-parties (ρ = 0.87, P < .001), PACs (ρ = 0.85, P < .0001), and overall (ρ = 0.8, P < .001). There was not a significant trend in contributions to presidential candidates (ρ = 0.71, P = .06).Conclusions: ROs' federal political contributions have significantly increased over the last decade and a half. This growth overwhelmingly represents contributions to specialty-focused PACs and both Democratic and Republican congressional candidates. [ABSTRACT FROM AUTHOR]- Published
- 2020
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5. Analysis of patent innovation in the field of brachytherapy.
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Miljanic, Mihailo, Prabhu, Arpan V., Patel, Mausam, Lewis, Gary D., and Kim, Thomas
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RADIOISOTOPE brachytherapy , *RADIATION sources , *TECHNOLOGICAL innovations , *PATENTS , *PATENT offices - Abstract
To characterize inventions and assess trends in brachytherapy innovation based on brachytherapy-related patents awarded across the past 2 decades and provide insights that will help inform future research and entrepreneurship in the field. The United States Patent and Trademark Office database was searched for patents awarded between 1999 and 2018 with a classification code corresponding to the broadest brachytherapy search category. Patent characteristics were stratified and compared by geographic location, affiliation, and theme of invention. There were 202 brachytherapy-related patents awarded from 2009 to 2018, which indicates a 56% increase in patent productivity and brachytherapy innovation compared with the previous decade from 1999 to 2008. Patents had an industry affiliation in 83% of cases from 1999 to 2008 and in 76% of cases from 2009 to 2018. Meanwhile, academic participation in brachytherapy patent innovation rose from 4% to 11% in that time. The focus and theme of inventions evolved across time, with radiation sources being the most common theme from 1999 to 2008 and falling to third place in 2009–2018. Conversely, development of brachytherapy-related patents involving exogenous agents such as drug-conjugates, radiosensitizers, and adjuncts to treatment increased substantially in the subsequent decade. While no collaboration was observed between academia and industry between 1999 and 2008, notable partnerships emerged in the subsequent decade which amounted to almost 5% of all patents awarded between 2009 and 2018. There has been an increase in overall brachytherapy patent production over time, and this has been accompanied by a greater variety of distinct patent themes. Collaboration between industry and academia is rare. Knowledge of brachytherapy patents may inform future research innovation in this field. [ABSTRACT FROM AUTHOR]
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- 2020
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6. Digital Era of Mobile Communications and Smartphones: A Novel Analysis of Patient Comprehension of Cancer-Related Information Available Through Mobile Applications.
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Kim, Christopher, Prabhu, Arpan V., Hansberry, David R., Agarwal, Nitin, Heron, Dwight E., and Beriwal, Sushil
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BREAST tumors , *COLON tumors , *LUNG tumors , *MEDICINE information services , *PATIENT education , *PROSTATE tumors , *READABILITY (Literary style) , *STOMACH tumors , *TELECOMMUNICATION , *TUMORS , *SMARTPHONES , *HEALTH literacy , *MOBILE apps , *HEALTH information services - Abstract
Many Americans use smartphone-based mobile applications to acquire health information. Our study evaluated the readability of mobile application-based patient educational materials (PEMs) about five prevalent cancers in the United States. The Apple and Google mobile application marketplaces were queried for breast, colon, lung, prostate, and stomach cancer-related applications, which were subsequently screened for PEMs and assessed with 10 validated readability assessments. Twenty-one pertinent applications yielded 249 articles that were written at an 11.8 ± 2.3 grade level; only 12 (4.8%) articles were written below an eighth grade level. The majority of cancer-related PEMs were written at too difficult reading levels for American patients. [ABSTRACT FROM AUTHOR]
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- 2019
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7. Twitter and brachytherapy: An analysis of "tweets" over six years by patients and health care professionals.
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Thomas, Joel, Prabhu, Arpan V., Heron, Dwight E., and Beriwal, Sushil
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RADIOISOTOPE brachytherapy , *ATTITUDES of medical personnel , *SOCIAL media , *MEDICAL care - Abstract
Abstract Purpose Twitter may reflect attitudes underrepresented in traditional surveys. This study aimed to understand professionals' and patients' thoughts regarding brachytherapy on Twitter. Methods and Materials Twitter was queried with "brachytherapy" to identify all tweets about patients' experiences from January 2012 to May 2017. A random sample of tweets by health care professionals containing "brachytherapy" was obtained using the first weekly tweet in the same interval. Consensus coding was used to categorize tweets as "patient" or "professional" based on content about receiving brachytherapy or self-identification as a health care professional. Tweets were analyzed for positive, neutral, or negative sentiment and recurrent themes using manual, iterative coding. Patient tweets were analyzed for whether they were shared before or after treatment and whether the patient, friends, or family had posted them. Professional tweets were analyzed to identify temporal theme changes. Results One hundred sixty-two patient tweets and 260 professional tweets were obtained from January 2012 to May 2017. On average, 2.5 patient tweets were shared monthly compared to 69 for providers. Among tweets by patients and professionals, 57% vs. 12% expressed positive sentiment, 21% vs. 3% negative sentiment, and 22% vs. 85% neutral sentiment, respectively. The most common patient and professional codes were "general sharing of experience/casual conversation" (32%) and "science" (21%), respectively. Conclusions Patients tweeted less about brachytherapy than professionals and generally expressed favorable and negative sentiments regarding their radiation treatment experiences. Professionals tended to express neutral sentiment and focus on research. Opportunities exist for greater radiation oncologist engagement in this medium. [ABSTRACT FROM AUTHOR]
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- 2018
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8. Improving margin revision: Characterization of tumor bed margins in early oral tongue cancer.
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Prabhu, Arpan V., Sturgis, Charles D., Lai, Chi, Maxwell, Jessica H., Merzianu, Mihai, Hernandez-Prera, Juan C., Purgina, Bibianna, Thompson, Lester D.R., Tuluc, Madalina, Yang, Xiu, Seethala, Raja R., Ferris, Robert L., and Chiosea, Simion I.
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ORAL cancer patients , *TONGUE cancer , *SQUAMOUS cell carcinoma , *GLOSSECTOMY , *CONFIDENCE intervals , *RESEARCH funding , *TUMOR classification , *EARLY detection of cancer , *DIAGNOSIS ,TONGUE tumors - Abstract
Objectives: To improve margin revision, this study characterizes the number, fragmentation, and orientation of tumor bed margins (TBM) in patients with pT1-2 pN0 squamous cell carcinoma (SCC) of the oral tongue.Materials and Methods: Pathology reports (n=346) were reviewed. TBM parameters were indexed. In Group 1 patients all margins were obtained from the glossectomy specimen and there were no TBM. In Revision Group/Group 2 (n=103), tumor bed was sampled to revise suboptimal margins identified by examination of the glossectomy specimen. In Group 3 (n=124), TBM were obtained before examination of the glossectomy specimen.Results and Conclusions: Fewer TBMs were obtained per patient in Group 2 compared to Group 3 (57/103, 55% of patients with <3 vs. 117/124, 94%, ≥3 TBMs, respectively). The new margin surface was more frequently indicated in Group 2 compared to Group 3 (59/103, 57%, vs. 19/124, 15%, p<.001). If glossectomy specimen margins are accepted as the reference standard, then the TBM was 15% sensitive in Group 2 (95% confidence interval [CI], 7-29) and 32% sensitive in Group 3 (95% CI, 15-55). TBM fragmentation (23/103, 22% vs. 42/124, 34%) and frozen vs. permanent discrepancies (8/103, 3% vs. 3/124, 2%) were similar between Groups 2 and 3. The new margin surface was not indicated in 6 of 11 cases with discrepant frozen vs. permanent pathology findings, precluding judgment on final margin status. To facilitate the assessment of final margins, TBM should be represented by one tissue fragment with a marked new margin surface. [ABSTRACT FROM AUTHOR]- Published
- 2017
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9. Reputation Management and Content Control: An Analysis of Radiation Oncologists' Digital Identities.
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Prabhu, Arpan V., Kim, Christopher, De Guzman, Eison, Zhao, Eric, Madill, Evan, Cohen, Jonathan, Hansberry, David R., Agarwal, Nitin, Heron, Dwight E., and Beriwal, Sushil
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ONLINE identities , *ONCOLOGISTS , *WEB search engines , *DIGITAL reputation , *CHI-squared test , *DATABASES , *INTERNET , *SOCIAL media - Abstract
Introduction: Google is the most popular search engine in the United States, and patients are increasingly relying on online webpages to seek information about individual physicians. This study aims to characterize what patients find when they search for radiation oncologists online.Methods and Materials: The Centers for Medicare and Medicaid Services (CMS) Physician Comparable Downloadable File was used to identify all Medicare-participating radiation oncologists in the United States and Puerto Rico. Each radiation oncologist was characterized by medical school education, year of graduation, city of practice, gender, and affiliation with an academic institution. Using a custom Google-based search engine, up to the top 10 search results for each physician were extracted and categorized as relating to: (1) physician, hospital, or health care system; (2) third-party; (3) social media; (4) academic journal articles; or (5) other.Results: Among all health care providers in the United States within CMS, 4443 self-identified as being radiation oncologists and yielded 40,764 search results. Of those, 1161 (26.1%) and 3282 (73.9%) were classified as academic and nonacademic radiation oncologists, respectively. At least 1 search result was obtained for 4398 physicians (99.0%). Physician, hospital, and health care-controlled websites (16,006; 39.3%) and third-party websites (10,494; 25.7%) were the 2 most often observed domain types. Social media platforms accounted for 2729 (6.7%) hits, and peer-reviewed academic journal websites accounted for 1397 (3.4%) results. About 6.8% and 6.7% of the top 10 links were social media websites for academic and nonacademic radiation oncologists, respectively.Conclusions: Most radiation oncologists lack self-controlled online content when patients search within the first page of Google search results. With the strong presence of third-party websites and lack of social media, opportunities exist for radiation oncologists to increase their online presence to improve patient-provider communication and better the image of the overall field. We discuss strategies to improve online visibility. [ABSTRACT FROM AUTHOR]- Published
- 2017
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10. The Neurosurgery Match: A Bibliometric Analysis of 206 First-Year Residents.
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Kashkoush, Ahmed, Prabhu, Arpan V., Tonetti, Daniel, and Agarwal, Nitin
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NEUROSURGERY , *MEDICAL students , *SCHOOL year , *QUANTITATIVE research , *REGRESSION analysis - Abstract
Background and Objective An important component of the residency application for neurosurgery is research experience and the subsequent number of produced publications. Bibliometrics research has been developed to establish quantitative methods for the standardization of publishing impactful research. This study aims to quantify the research productivity of medical students who successfully matriculated into a Neurosurgery residency program. Methods We initially identified first-year neurosurgery residents for the 2016–2017 academic year of all U.S. neurosurgical residency programs through departmental websites. The Scopus database was then queried for all articles published in the years 2006 to 2015 by first-year residents and bibliometric variables, such as publication count, journal impact factors, and author h-index, were extracted. The main outcome measured was residency program, tiered 1–5 by total departmental faculty research output. Results Two hundred six (206) Scopus records for first-year neurosurgery residents were identified in 99 programs nationwide. Multivariate ordinal regression demonstrated that only h-index was independently associated with tier of matriculation ( P = 0.043). H-index was observed to strongly correlate with the number of original research articles ( P = 0.005), years since first publication ( P < 0.0001), and journal impact factor ( P = 0.048) as assessed by multiple linear regression. Notably, h-index was observed to increase by approximately 1 point with every 3 original research articles (B = 0.368) and 4 years since first publication (B = 0.257). Conclusions H-index is a powerful research predictor of matching into neurosurgical research institutions and can be improved by starting research early, targeting high impact journals, and participating in original clinical and laboratory investigations. [ABSTRACT FROM AUTHOR]
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- 2017
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11. Fat: friend or foe? A review of fat-containing masses within the head and neck.
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KALE, HRISHIKESH A., PRABHU, ARPAN V., SINELNIKOV, ANDREY, and BRANSTETTER IV, BARTON
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Fat-containing lesions of the head and neck are commonly encountered in day-to-day practice. Our aim was to review the various imaging presentations of common and some uncommon fat-containing lesions within the head and neck with potential pitfalls and mimics. While most soft-tissue masses have a fairly similar density, the presence of fat in a mass lesion is easy to identify on both CT/MRI and can help narrow the differential. Case-based examples of lipomas, liposarcomas, lipoblastomas, dermoids, teratomas and other fatty lesions will be used to describe imaging features. While fat density can be helpful, differentiating benign from malignant fat-containing lesions can still pose a challenge. Lesions simulating pathology such as brown fat, fatty changes within organs and post-operative flaps are presented. Finally, examples of fatty lesions in atypical locations are shown to illustrate examples that should be kept in mind in any differential. The presence of fat in head and neck masses can aid radiologists in arriving at an accurate diagnosis. Knowledge of the imaging appearance of these fat-containing lesions and their mimics can help avoid unnecessary biopsy or surgery. [ABSTRACT FROM AUTHOR]
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- 2016
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12. Radiation Oncology and Online Patient Education Materials: Deviating From NIH and AMA Recommendations.
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Prabhu, Arpan V., Hansberry, David R., Agarwal, Nitin, Clump, David A., and Heron, Dwight E.
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PATIENT education , *MEDICAL care , *RADIOTHERAPY , *MEDICAL literature , *PHYSICIAN-patient relations , *INFORMATION literacy standards , *INTERNET , *MEDICAL protocols , *ONCOLOGY , *ONLINE information services , *READABILITY (Literary style) , *INFORMATION literacy ,WRITING - Abstract
Purpose: Physicians encourage patients to be informed about their health care options, but much of the online health care-related resources can be beneficial only if patients are capable of comprehending it. This study's aim was to assess the readability level of online patient education resources for radiation oncology to conclude whether they meet the general public's health literacy needs as determined by the guidelines of the United States National Institutes of Health (NIH) and the American Medical Association (AMA).Methods: Radiation oncology-related internet-based patient education materials were downloaded from 5 major professional websites (American Society for Radiation Oncology, American Association of Physicists in Medicine, American Brachytherapy Society, RadiologyInfo.org, and Radiation Therapy Oncology Group). Additional patient education documents were downloaded by searching for key radiation oncology phrases using Google. A total of 135 articles were downloaded and assessed for their readability level using 10 quantitative readability scales that are widely accepted in the medical literature.Results: When all 10 assessment tools for readability were taken into account, the 135 online patient education articles were written at an average grade level of 13.7 ± 2.0. One hundred nine of the 135 articles (80.7%) required a high school graduate's comprehension level (12th-grade level or higher). Only 1 of the 135 articles (0.74%) met the AMA and NIH recommendations for patient education resources to be written between the third-grade and seventh-grade levels.Conclusion: Radiation oncology websites have patient education material written at an educational level above the NIH and AMA recommendations; as a result, average American patients may not be able to fully understand them. Rewriting radiation oncology patient education resources would likely contribute to the patients' understanding of their health and treatment options, making each physician-patient interaction more productive and efficient. [ABSTRACT FROM AUTHOR]- Published
- 2016
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13. Impact of Individualized Patient Education Material on Patients' Cancer Care Experiences.
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D'Souza, Leah A, Prabhu, Arpan V, Roy, Soumyajit, and Marwaha, Gaurav
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PATIENT education , *CANCER patient care , *HEALTH literacy , *ONCOLOGY nursing , *INDIVIDUALIZED instruction , *PATIENT satisfaction - Abstract
Patient education materials (PEMs) empower patients to have an understanding of their health and treatment options. PEMs that currently exist in Radiation Oncology are available primarily as text heavy resources, or multiple-click web-based Internet resources, exceeding the national readability recommendation of a 6th grade reading level. A health literacy level appropriate PEM that simplifies the complexity of a cancer diagnosis and treatment options may be a reasonable option to facilitate patient-provider communication in Oncology. We are developing a multidisciplinary, health literacy appropriate thoracic oncology PEM at Rush University Medical Center (RUMC) in Chicago, IL, which serves a diverse patient population with varying health literacy levels. This new PEM, part of an ongoing study, aims to address the knowledge translation gap. The primary outcome is to assess the mean difference in patient satisfaction between control and study groups. The secondary outcome is to assess an interaction effect between health literacy and the overall effect of the PEM on patient satisfaction. This prospective randomized control trial with IRB approval is ongoing. The PEM was developed collaboration with media designers and the RUMC Patient Education Committee. Readability of the PEM was assessed with ten common readability assessment scales, represented through a mean score. All English or Spanish speaking adults scheduled for a new patient consult during Comprehensive Lung Clinic will be included. The control group will receive the standard of care (physician encounter without the PEM), while the intervention group will receive standard of care and the PEM. All patients will complete an anonymized validated survey that measures health literacy levels, sociodemographic factors, and satisfaction of the encounter. A cumulative anonymized health-care provider survey will gather descriptive data about health-care providers' experiences using the PEM. Descriptive statistics will characterize the control and study group. Patient satisfaction will be measured on a 5-point scale. A two-sample t-test with a one-sided alternative will measure the difference of mean score of patient satisfaction between the control and study group. We will apply interaction tests to determine the differential impact of health literacy on the correlation of the PEM and patient satisfaction. Multiple linear regression modeling will be done to determine the correlation of the PEM and patient satisfaction after adjusting for other socio-demographic variables. If received well, we will explore expanding this study to other treatment sites, with the overall goal of improving health literacy appropriate PEMs in Radiation Oncology. [ABSTRACT FROM AUTHOR]
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- 2022
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14. A Window to Internet-based Information Seeking of US Fourth-Year Medical Students: Are Radiation Oncology Residency Program Websites Comprehensive?
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Prabhu, Arpan V., Karukonda, Pooja, Hansberry, David R., Heron, Dwight E., Jr.thomas, Charles R., and Thomas, Charles R Jr
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ONLINE education , *MEDICAL students , *RADIOTHERAPY - Published
- 2018
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15. (P50) What Do Patients Think About Their Radiation Oncologists: An Assessment of Online Patient Reviews on Healthgrades.
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Prabhu, Arpan V., Randhawa, Simrath, Clump, David A., Heron, Dwight E., and Beriwal, Sushil
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PATIENT satisfaction , *INTERNET surveys , *ONCOLOGISTS , *PHYSICIANS - Published
- 2018
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16. Advocating for preclinical surgical skills curricula during medical school.
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Kashkoush, Ahmed I., Prabhu, Arpan V., and Agarwal, Nitin
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YOUNG adults , *ADULTS , *HIGHER education , *PROFESSIONAL education , *CURRICULUM , *MEDICAL education , *OPERATIVE surgery , *LEARNING strategies , *VOCATIONAL guidance - Published
- 2017
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17. YouTube as a Source of Patient Information: Assessing Quality of Information in Brachytherapy Education Videos.
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Prabhu, Arpan V., Horne, Zachary, Glaser, Scott, Rajagopalan, Malolan, and Beriwal, Sushil
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RADIOISOTOPE brachytherapy - Published
- 2017
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18. Thoracic spinal osteochondroma: A rare presentation of spinal cord compression.
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Hansberry, David R., Gupta, Raghav, Prabhu, Arpan V., Agarwal, Nitin, Cox, Mougnyan, Joneja, Upasana, Curtis, Mark T., Harrop, James S., and Flanders, Adam E.
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OSTEOCHONDROMA , *THORACIC vertebrae , *SPINAL cord , *PROPRIOCEPTION , *COMPUTED tomography , *SPINAL cord diseases , *PARESTHESIA , *TUMORS , *MAGNETIC resonance imaging - Abstract
Osteochondromas are the most common benign bone tumor typically seen in the appendicular skeleton and are rarely found in the spine. We present a case of an osteochondroma of the spine presenting with spinal cord compression. 27-year-old male presented with lower extremity weakness and paresthesia, decreased lower extremity sensation, and decreased proprioception. MRI showed a heterogeneous mass with minimal peripheral enhancement and without restricted diffusion. CT demonstrated a calcified mass extending from the left facet joint of T11–T12 with medial extension, resulting in severe central canal stenosis and cord compression. The patient underwent surgical resection with pathology demonstrating an osteochondroma. [ABSTRACT FROM AUTHOR]
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- 2017
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19. Postoperative Complications for Elderly Patients After Single-Level Lumbar Fusions for Spondylolisthesis.
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Lieber, Bryan A., Chiang, Vicky, Prabhu, Arpan V., Agarwal, Nitin, Henry, Jensen K., Lin, Derek, Kazemi, Noojan, and Tabbosha, Monir
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SPONDYLOLISTHESIS , *SURGICAL complications , *SPINAL fusion , *COMORBIDITY , *OBSTRUCTIVE lung diseases , *DISEASES in older people , *THERAPEUTICS - Abstract
Objective A large-scale study on postoperative complications of lumbar fusion surgery for spondylolisthesis comparing patients >80 years old with younger patients has not been performed. The purpose of this study is to assess the effects of extreme age (>80 years old) on early postoperative outcomes after single-level lumbar fusions for spondylolisthesis. Methods From a validated multicenter surgical database, 2475 patients who underwent a single-level lumbar fusion procedure for spondylolisthesis were selected retrospectively. An extreme age cohort with 227 patients >80 years old was compared with a typical age cohort with 2248 patients 45–65 years old. Results The preoperative characteristics and comorbidities were different between the typical age cohort and the extreme age cohort, with older patients having more preoperative comorbidities, including a lack of independent functional health status before surgery ( P < 0.001), severe chronic obstructive pulmonary disease ( P <0.020), and hypertension requiring medication ( P < 0.001). There was significantly greater morbidity among the >80 cohort regarding urinary tract infection ( P = 0.008; odds ratio = 3.30; 95% confidence interval, 1.47–7.40) and intraoperative and postoperative transfusions ( P < 0.001; odds ratio = 2.186; 95% confidence interval, 1.54–3.11). There was significantly greater morbidity among the younger cohort regarding cardiac arrest requiring cardiopulmonary resuscitation ( P = 0.043; odds ratio = 0.099; 95% confidence interval, 0.014–0.704). Conclusions This is the first large study comparing the rates of postoperative complications of lumbar fusion surgery for spondylolisthesis in patients >80 years old versus younger patients. The data support that age alone should not exclude a patient for this procedure. However, extra caution is warranted given the slightly increased morbidity. [ABSTRACT FROM AUTHOR]
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- 2016
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20. The #PalliativeCare Conversation on Twitter: An Analysis of Trends, Content, and Caregiver Perspectives.
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Padmanabhan, Divya L., Ayyaswami, Varun, Prabhu, Arpan V., Sinclair, Christian, and Gugliucci, Marilyn R.
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CONVERSATION analysis , *TREND analysis , *PALLIATIVE treatment , *MEDICAL personnel , *QUALITY of life , *CAREGIVERS , *RESEARCH , *SOCIAL media , *CROSS-sectional method , *RESEARCH methodology , *MEDICAL cooperation , *EVALUATION research , *COMPARATIVE studies , *COMMUNICATION - Abstract
Context: Palliative care is known to improve patients' quality of life, but oftentimes these conversations occur outside of the health-care setting.Objectives: To characterize the #PalliativeCare Twitter network and evaluate the caregiver experience within palliative care.Methods: In this cross-sectional study, a total of 182,661 #PalliativeCare tweets by 26,837 users from June 1, 2015 to June 1, 2019 were analyzed using Symplur Signals. Analysis included activity metrics, content analysis, user characteristics, engagement, and network analysis. Similar metrics were performed on tweets by self-identified caregivers (482), who wrote a total of 3952 tweets. Qualitative analysis was completed on a systematic sample of caregiver tweets.Results: The number of #PalliativeCare tweets, users, and impressions has increased by an annual average of 18.7%, 16.4%, and 32.5%, respectively. Support, access, and patients were among the Trending Terms. About 39.4% of Trending Articles were scientifically valid, and information about palliative care and comorbidities had the greatest number of articles. The majority of users wrote five or less #PalliativeCare tweets. Network analysis revealed central hubs to be palliative care advocacy organizations and physicians. The five main themes from qualitative analysis of caregiver tweets were 1) advocacy and events, 2) care strategies, 3) resources, 4) public health issues, and 5) myths related to palliative care.Conclusion: The use of Twitter as a platform for palliative care conversations is growing rapidly. Twitter serves as a platform to facilitate #PalliativeCare conversation among patients, caregivers, physicians, and other healthcare providers. [ABSTRACT FROM AUTHOR]- Published
- 2021
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21. Brachytherapy vs external beam therapy among NSCLC patients undergoing limited surgical resection.
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Patel, Mausam A., Fazli, Yama, Sivakumar, Sowmya, Dennis, Coleman, Maraboyina, Sanjay, Prabhu, Arpan V., and Kim, Thomas
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SURGICAL excision , *RADIOTHERAPY , *RADIOISOTOPE brachytherapy , *PROPORTIONAL hazards models , *FISHER exact test - Abstract
Purpose: To compare brachytherapy to external beam radiation therapy (EBRT) with respect to overall survival (OS) and disease-specific survival (DSS) among NSCLC patients undergoing limited surgical resection. Methods: All cases of T1-4 N0 M0 NSCLC undergoing limited resection and either brachytherapy or EBRT diagnosed between 2004 and 2014 were extracted from the Surveillance, Epidemiology, and End Results database. Chi-square test and Fisher's exact analysis were used to analyze categorical variables while Student's t-test was used to analyze continuous variables. Univariate analysis to assess for differences in survival with respect to covariates was performed with the log-rank test. Multivariable analysis was performed with Cox proportional hazards regression models among the entire cohort and after sub-stratification by T stage. Results: Among 543 patients, 471 underwent EBRT and 72 underwent brachytherapy. Brachytherapy demonstrated improved OS and DSS on univariate analysis as compared to EBRT (p < 0.05). Cox regression also demonstrated improved OS and DSS with brachytherapy (HR 0.604; 95% CI [0.380; 0.961] and HR 0.524; 95% CI [0.303; 0.908], respectively). Sub-cohort analysis demonstrated significant improvement in survival only among patients with T1 disease with similar survival between brachytherapy and EBRT among higher stage disease. Conclusions: Patients undergoing brachytherapy for T1-T4, N0, M0 NSCLC demonstrated at least similar survival as compared to those undergoing EBRT among patients undergoing limited resection. Improved survival was demonstrated among patients with T1 disease. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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22. Mobile health applications for atrial fibrillation: A readability and quality assessment.
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Ayyaswami, Varun, Padmanabhan, Divya L., Crihalmeanu, Tudor, Thelmo, Franklin, Prabhu, Arpan V., and Magnani, Jared W.
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ATRIAL fibrillation , *MOBILE apps , *MEDICAL personnel , *HEALTH literacy , *APPLICATION stores - Abstract
Mobile health applications may improve patient education and self-care for a complex condition such as atrial fibrillation (AF). Little is known about the accessibility of mobile health applications ("apps") and their readability. We evaluated the readability and quality of available apps for AF. We searched the Apple and Google Play app stores with the terms "atrial fibrillation" and "afib." We downloaded English-language apps (up to n = 100 for each term) and categorized them by name, App store, cost, content, uploading agency (heath care associated [HCA] versus non-HCA), target audience (health care professional [HCP] versus non-HCP), scientific validity (i.e., citation of peer-reviewed or validated medical information), and user ratings. We analyzed the text of apps intended for a non-HCP target audience for readability with 10 established measures. Of the 206 downloaded apps, 50.5% were excluded as unrelated to AF, inaccessible, or non-English language. The majority of apps contained information about AF (63.2% Apple, 52.2% Google Play) and AF detection (52.6% Apple, 56.5% Google Play). A minority of non-HCP apps contained scientifically validated content (Apple, 15.8%; Google Play, 13.0%; P = NS). App mean readability was grade 12.1 ± 2.6. Most AF apps lacked scientific validation and were written at excessively high reading-grade levels. Our results suggest caution with mobile health apps, particularly for users with limited health literacy. There is potential opportunity for a multi-disciplinary effort by regulatory agencies, healthcare organizations, and app stores to improve relevance, scientific validity, and readability of AF apps for patients with this complex and morbid disease. • We systematically examined smartphone apps for atrial fibrillation. • In the majority of apps, we identified content that lacked scientific validation. • Materials for patient education were written at very high reading-grade levels. • We suggest professional society guidelines for app quality and readability. [ABSTRACT FROM AUTHOR]
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- 2019
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23. Descriptive Analysis of State and Federal Spine Surgery Malpractice Litigation in the United States.
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Agarwal, Nitin, Gupta, Raghav, Agarwal, Prateek, Matthew, Pravin, Wolferz Jr, Richard, Shah, Aakash, Adeeb, Nimer, Prabhu, Arpan V., Kanter, Adam S., Okonkwo, David O., Hamilton, David Kojo, and Wolferz, Richard Jr
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SPINAL surgery , *MALPRACTICE -- Lawsuits & claims , *MEDICAL malpractice , *MEDICAL decision making , *NEUROSURGEONS , *MALPRACTICE , *FEDERAL government , *RESEARCH methodology , *MEDICAL care costs , *MEDICAL laws , *NEUROSURGERY , *ORTHOPEDIC surgery , *LEGAL procedure , *STATE governments , *RETROSPECTIVE studies - Abstract
Study Design: A retrospective review.Objective: This study aimed to determine the factors associated with malpractice litigation in cases involving spine surgery in the United States.Summary Of Background Data: Medical malpractice is of substantial interest to the medical community due to concerns of increased health care costs and medical decision-making for the sole purpose of reducing legal liability.Methods: The Westlaw online legal database (Thomson Reuters, New York, NY) was searched for verdict and settlement reports pertaining to spine surgery from 2010 to 2015. Data were collected regarding type of procedure, patient age and gender, defendant specialty, outcome, award, alleged cause of malpractice, and factors involved in the plaintiff's decision to file. Initial search queried 187 cases, after which exclusion criteria were applied to eliminate duplicates and cases unrelated to spine surgery, yielding a total of 98 cases for analysis.Results: The verdict was in favor of the defendant in 62 cases (63.3%). Neurosurgeons and orthopedic surgeons were the most common defendants in 29 (17.3%) and 40 (23.8%) of the cases, respectively. A perceived lack of informed consent was noted as a factor in 24 (24.4%) of the cases. A failure to diagnose or a failure to treat was noted in 31 (31.6%) and 32 (32.7%) cases, respectively. Median payments for plaintiff verdicts were nearly double those of settlements ($2,525,000 vs. $1,300,000). A greater incidence of plaintiff verdicts was noted in cases in which a failure to treat (P < 0.05) was cited, a patient death occurred (P < 0.05), or an emergent surgery had been performed (P < 0.01).Conclusion: Overall, physicians were not found liable in the majority of spine surgery malpractice cases queried.Level Of Evidence: 4. [ABSTRACT FROM AUTHOR]- Published
- 2018
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24. Quantitative analysis of the level of readability of online emergency radiology-based patient education resources.
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Hansberry, David R., D’Angelo, Michael, White, Michael D., Prabhu, Arpan V., Cox, Mougnyan, Agarwal, Nitin, Deshmukh, Sandeep, and D'Angelo, Michael
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EMERGENCY medical services , *MEDICAL radiology , *PATIENT education , *INTERNET in education , *MEDICAL informatics , *DIAGNOSTIC imaging , *INTERNET , *MEDICAL protocols , *READABILITY (Literary style) , *INFORMATION literacy - Abstract
Purpose: The vast amount of information found on the internet, combined with its accessibility, makes it a widely utilized resource for Americans to find information pertaining to medical information. The field of radiology is no exception. In this paper, we assess the readability level of websites pertaining specifically to emergency radiology.Methods: Using Google, 23 terms were searched, and the top 10 results were recorded. Each link was evaluated for its readability level using a set of ten reputable readability scales. The search terms included the following: abdominal ultrasound, abdominal aortic aneurysm, aortic dissection, appendicitis, cord compression, CT abdomen, cholecystitis, CT chest, diverticulitis, ectopic pregnancy, epidural hematoma, dural venous thrombosis, head CT, MRI brain, MR angiography, MRI spine, ovarian torsion, pancreatitis, pelvic ultrasound, pneumoperitoneum, pulmonary embolism, subarachnoid hemorrhage, and subdural hematoma. Any content that was not written for patients was excluded.Results: The 230 articles that were assessed were written, on average, at a 12.1 grade level. Only 2 of the 230 articles (1%) were written at the third to seventh grade recommended reading level set forth by the National Institutes of Health (NIH) and American Medical Association (AMA). Fifty-two percent of the 230 articles were written so as to require a minimum of a high school education (at least a 12th grade level). Additionally, 17 of the 230 articles (7.3%) were written at a level that exceeded an undergraduate education (at least a 16th grade level).Conclusions: The majority of websites with emergency radiology-related patient education materials are not adhering to the NIH and AMA's recommended reading levels, and it is likely that the average reader is not benefiting fully from these information outlets. With the link between health literacy and poor health outcomes, it is important to address the online content in this area of radiology, allowing for patient to more fully benefit from their online searches. [ABSTRACT FROM AUTHOR]- Published
- 2018
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25. Fostering Student Interest in Neurologic Surgery: The University of Pittsburgh Experience.
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Kashkoush, Ahmed, Feroze, Rafey, Myal, Stephanie, Prabhu, Arpan V., Sansosti, Alexandra, Tonetti, Daniel, and Agarwal, Nitin
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MEDICAL students , *STUDENT interests , *SURGERY , *SCHOOL year , *NEUROSURGERY , *SUTURING - Abstract
Introduction Early involvement and research in neurosurgery can increase chances for medical students to matriculate successfully into residency. This study reports the creation of a Neurological Surgery Interest Group (NSIG) at the University of Pittsburgh School of Medicine and shares its activities over 2 academic years. Methods In October 2014, the University of Pittsburgh School of Medicine's NSIG was created to augment medical student interest in neurosurgery. The group consisted of 4 appointed officers for a membership base of 100 students. In June 2015, a neurosurgery resident and faculty member joined as mentors. A research committee of 14 medical students was created to conduct collaborative research projects with the department. In August of 2015 and 2016, surveys were sent out to the research committee regarding research productivity. Results The NSIG hosted 17 medical student-oriented events over 2 years, including didactic and suturing workshops, senior faculty panels, postmatch talks, and a neurosurgery networking dinner. A survey of students about scholarly achievement in neurosurgery reported 17 accepted publications in peer-reviewed journals with a mean impact factor of 3.5 ± 2.5. Ten abstracts were submitted to the 2015 and 2016 American Association of Neurological Surgeons Scientific Meetings, with a 100% acceptance rate. An increase in the number of students matching from our institution into neurosurgery residencies was observed following the group's inception. Conclusions An NSIG can be mutually beneficial to both medical students and an institution's neurosurgical department. This study's findings may be applied to numerous specialties and across various academic institutions. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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26. Racial diversity in melanoma research from 2015 to 2020: a cross‐sectional study.
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Nickles, Melissa A., Kulkarni, Vishnutheertha, Garg, Swati P., Patel, Mit M., Kirchner, Allison, and Prabhu, Arpan V.
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CROSS-sectional method , *CLINICAL trial registries , *MEDICAL personnel , *HISPANIC Americans - Abstract
Hispanics were the only group that were underrepresented, as all other races/ethnicities had nearly equal representation in melanoma clinical trials relative to the melanoma prevalence percentages. Dear Editor, Melanoma incidence is increasing in the United States without decreases in mortality.1 While Whites have the highest rates of melanoma, people of color (POC) experience a lower overall survival rate for cutaneous melanoma and are diagnosed at later stages.1 Recent data suggest that racial disparity in melanoma-specific survival has worsened since 2010 for Hispanics, non-Hispanic Blacks, and non-Hispanic Asian or Pacific Islanders.2 POC have historically been excluded from medical research, and the National Institutes of Health (NIH) now mandates the inclusion of women and minority groups in all NIH-funded clinical research. In this study, we sought to analyze the racial diversity of participants in recent melanoma research, specifically studies published from 2015 to 2020, to compare clinical trial data with the most recently published prevalence rates of melanoma. [Extracted from the article]
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- 2022
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27. Ventral Spontaneous Durotomy Following Vaginal Delivery.
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Agarwal, Nitin, Kashkoush, Ahmed I., Prabhu, Arpan V., and Sekula, Raymond F.
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DELIVERY (Obstetrics) , *MATERNAL health , *CEREBROSPINAL fluid , *EPIDURAL blood patch , *MAGNETIC resonance imaging , *COMPUTED tomography - Abstract
Background Dural breaches have a diverse etiology, including spontaneous rupture and trauma. Most cases resolve with bed rest; in refractory cases, an epidural blood patch can be placed to obstruct further leakage. We discuss a unique case of a spontaneous ventral durotomy following vaginal delivery that was managed with injections of autologous blood through bilateral transforaminal needles. Case Description A previously healthy, 36-year-old pregnant woman presented to the inpatient maternity ward with positional occipital headaches and neck pain 24 hours after normal spontaneous vaginal delivery. Two dorsally placed epidural blood patches provided only transient relief. Computed tomography myelography revealed ventral cerebrospinal fluid leak. Targeted therapy was provided with computed tomography–guided ventral placement of a blood patch. Conclusions Spontaneous durotomy is a rare phenomenon and should be considered in patients who present with positional headaches. Ventrally targeted therapy via an epidural blood patch should be considered to provide optimal relief. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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28. Digital Footprint of Neurological Surgeons.
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Kim, Christopher, Gupta, Raghav, Shah, Aakash, Madill, Evan, Prabhu, Arpan V., and Agarwal, Nitin
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MEDICAL informatics , *NEUROSURGEONS , *MEDICAL databases , *SOCIAL media in medicine - Abstract
Background Patients are increasingly turning to online resources to inquire about individual physicians and to gather health information. However, little research exists studying the online presence of neurosurgeons across the country. This study aimed to characterize these online profiles and assess the scope of neurosurgeons' digital identities. Methods Medicare-participating neurologic surgeons from the United States and Puerto Rico were identified using the Centers for Medicare and Medicaid Services (CMS) Physician Comparable Downloadable File. Each physician was characterized by his or her medical education, graduation year, city of practice, gender, and affiliation with an academic institution. Using a Google-based custom search tool, the top 10 search results for each physician were extracted and categorized as 1 of the following: 1) physician, hospital, or healthcare system controlled, 2) third-party or government controlled, 3) social media–based, 4) primary journal article, or 5) other. Results Among the physicians within the CMS database, 4751 self-identified as being neurosurgeons, yielding a total of 45,875 uniform resource locator search results pertinent to these physicians. Of the 4751 neurosurgeons, 2317 (48.8%) and 2434 (51.2%) were classified as academic and nonacademic neurosurgeons, respectively. At least 1 search result was obtained for every physician. Hospital, healthcare system, or physician-controlled websites (18,206; 39.7%) and third-party websites (17,122; 37.3%) were the 2 most commonly observed domain types. Websites belonging to social media platforms accounted for 4843 (10.6%) search results, and websites belonging to peer-reviewed academic journals accounted for 1888 (4.1%) search results. The frequency with which a third-party domain appeared as the first search result was higher for nonacademic neurosurgeons than for academic neurosurgeons. Conclusions In general, neurosurgeons lacked a controllable online presence within their first page of Google Search results. Third-party physician rating websites constituted about half of the search results, and a relative lack of social media websites was apparent. Still, numerous opportunities exist for neurosurgeons to address this disparity. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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