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10 results on '"Prabu, Rajesh"'

1. Electroretinogram as a Screening Tool to Assess Vigabatrin-Induced Retinal Toxicity in Children With Infantile Spasms.

Author

Nagarajan, Suruthi, Prabu, Rajesh, Parachuri, Nikulaa, and Thulasidas, Mithun

Subjects
INFANTILE spasms, ELECTRORETINOGRAPHY, TUBEROUS sclerosis, LENNOX-Gastaut syndrome, STRABISMUS, TREATMENT duration
Abstract

Purpose: To assess the utility of electroretinogram (ERG) as a screening tool for vigabatrin-induced retinal toxicity in children with infantile spasms. Methods: This was an observational cohort study including children with infantile spasms receiving treatment with vigabatrin. A 30-Hz flicker potential ERG, using the RETeval system (LKC Technologies), was done at baseline before starting vigabatrin at 6 months and 1 year. The amplitudes were recorded. Results: Eleven children were included in the study. The most common etiologic factor for infantile spasms was tuberous sclerosis (36.4%) followed by West syndrome (27.3%). The mean age of the children was 7.14 ± 2.9 months, with a range of 3 to 16 months. The mean difference in amplitude was 3.21 ± 2.45 and 5.72 ± 4.18 µV at 6 and 12 months follow-up, respectively (P <.001). Eight of the 11 children (72.7%) showed vigabatrin-induced retinal toxicity, and all 8 children were receiving vigabatrin for more than 6 months. Conclusions: ERG can be used for vigabatrin-induced retinal toxicity monitoring in children with infantile spasms. Vigabatrin-induced retinal toxicity is related to the duration of treatment rather than cumulative dosage. [J Pediatr Ophthalmol Strabismus. 2024;61(4):273–278.] [ABSTRACT FROM AUTHOR]

Published
2024
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2. Bilateral optic neuritis as a presentation of myelin oligodendrocyte glycoprotein antibody associated disease in a child

Author

Raghavan, Sai, Prabu, Rajesh, Mohan, Shruti, and Nagarajan, Suruthi

Subjects
Brain damage -- Prognosis, Children -- Diseases, Multiple sclerosis -- Prognosis, Viral antibodies, Myelin proteins, Antibodies, Health
Abstract

Byline: Sai. Raghavan, Rajesh. Prabu, Shruti. Mohan, Suruthi. Nagarajan Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), although rare, is now recognized as a distinct demyelinating disorder. The entity differs from multiple [...]

Published
2023

4. A case report of children of the same family presenting with congenital cataract- as part of a rare genetic disorder-Sengers Syndrome

Author

Prabu, Rajesh, Priyambada, Parul, Ranjini, H., and Wasnik, Rajlaxmi

Subjects
Genetic disorders -- Diagnosis -- Care and treatment -- Case studies, Ocular manifestations of general diseases -- Diagnosis -- Care and treatment -- Case studies, Cataract -- Diagnosis -- Care and treatment -- Case studies, Health
Abstract

Byline: Rajesh. Prabu, Parul. Priyambada, H. Ranjini, Rajlaxmi. Wasnik Sengers syndrome is a rare autosomal recessive mitochondrial disorder characterized by congenital cataract, hypertrophic cardiomyopathy, and mitochondrial myopathy. We report two [...]

Published
2020

6. A case report of anterior visual pathway aplasia

Author

Reddy, Jakkidi, Shanker, Prabhu, Ganesan, Geetha, and Prabu, Rajesh

Subjects
Eye diseases -- Research, Magnetic resonance imaging -- Usage, Optic nerve -- Health aspects, Health
Abstract

Byline: Jakkidi. Reddy, Prabhu. Shanker, Geetha. Ganesan, Rajesh. PrabuCase ReportA 6-year-old male child presented with no vision in both eyes, born to a nonconsanguineous marriage with uneventful perinatal period. Physical [...]

Published
2019

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