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817 results on '"Prager, G."'

7. The management of hepatocellular carcinoma. Current expert opinion and recommendations derived from the 24th ESMO/World Congress on Gastrointestinal Cancer, Barcelona, 2022

Author

Ducreux, M., Abou-Alfa, G.K., Bekaii-Saab, T., Berlin, J., Cervantes, A., de Baere, T., Eng, C., Galle, P., Gill, S., Gruenberger, T., Haustermans, K., Lamarca, A., Laurent-Puig, P., Llovet, J.M., Lordick, F., Macarulla, T., Mukherji, D., Muro, K., Obermannova, R., O’Connor, J.-M., O’Reilly, E.M., Osterlund, P., Philip, P., Prager, G., Ruiz-Garcia, E., Sangro, B., Seufferlein, T., Tabernero, J., Verslype, C., Wasan, H., and Van Cutsem, E.

Published
2023
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12. Metachronous hepatic resection for liver only pancreatic metastases

Author

Schwarz, C., Fitschek, F., Primavesi, F., Stättner, S., Margonis, G.A., Weiss, M.A., Stavrou, G.A., Oldhafer, K.J., Kornprat, P., Wundsam, H., Fischer, I., Längle, F., Függer, R., Hauer, A., Klug, R., Kieler, M., Prager, G., Schindl, M., Stremitzer, S., Bodingbauer, M., Sahora, K., and Kaczirek, K.

Published
2020
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15. Perioperative Interventions to Prevent Gastroesophageal Reflux Disease and Marginal Ulcers After Bariatric Surgery — an International Experts’ Survey

Author

Chiappetta, S., Stier, C., Ghanem, O. M., Dayyeh, B. K. A., Boskoski, Ivo, Prager, G., Lamasters, T., Kermansaravi, M., Aarts, E., Abbas, I., Angrisani, L., Antozzi, L., Asghar, T., Bashir, A., Behrens, E., Bhandari, M., Bhasker, A., Billy, H., Carbajo, M. -A., Chevallier, J. M., Cohen, R., Dargent, J., De Luca, M., de Moura, E., Dillemans, B., Di Lorenzo, N., Hayssam El Fawal, M., Moritz Felsenreich, D., Fishman, S., Gagner, M., Galvao, M., Gawdat, K., Gee, T., Ghavami, B., Haddad, A., Hanssen, A., Herrera, M. F., Higa, K., Himpens, J. M., Kasama, K., Kassir, R., Khan, A., Khidir, N., Khoursheed, M., Khwaja, H., Kow, L., Kroh, M., Singh Kular, K., Lainas, P., Lakdawala, M., Layani, L., Loi, K., Mahawar, K., Mahdy, T., Mala, T., Miller, K., Musella, Martina, Neymark, A., Nimeri, A., Nocca, D., Noel, P., Omarov, T., Palermo, M., Parmar, C., Pazouki, A., Poggi, L., Poghosyan, T., Pompa, L., Ponce, J., Pournaras, D., Prasad, A., Alqahtani, A., Ramos, A., Rezvani, M., Rheinwalt, K., Ribeiro, R., Rotundo, A., Ruiz-Ucar, E., Safadi, B., Sakran, N., Salminen, P., Schroeder, O., Seki, Y., Shabbir, A., Shahabi Shahmiri, S., Shikora, S., Stein, J., Stenberg, E., Taskin, E., Torres, A., Villalonga, R., Weiner, R., Weiner, S., Yang, W., Zehetner, J., Zundel, N., Boskoski I. (ORCID:0000-0001-8194-2670), Musella M., Chiappetta, S., Stier, C., Ghanem, O. M., Dayyeh, B. K. A., Boskoski, Ivo, Prager, G., Lamasters, T., Kermansaravi, M., Aarts, E., Abbas, I., Angrisani, L., Antozzi, L., Asghar, T., Bashir, A., Behrens, E., Bhandari, M., Bhasker, A., Billy, H., Carbajo, M. -A., Chevallier, J. M., Cohen, R., Dargent, J., De Luca, M., de Moura, E., Dillemans, B., Di Lorenzo, N., Hayssam El Fawal, M., Moritz Felsenreich, D., Fishman, S., Gagner, M., Galvao, M., Gawdat, K., Gee, T., Ghavami, B., Haddad, A., Hanssen, A., Herrera, M. F., Higa, K., Himpens, J. M., Kasama, K., Kassir, R., Khan, A., Khidir, N., Khoursheed, M., Khwaja, H., Kow, L., Kroh, M., Singh Kular, K., Lainas, P., Lakdawala, M., Layani, L., Loi, K., Mahawar, K., Mahdy, T., Mala, T., Miller, K., Musella, Martina, Neymark, A., Nimeri, A., Nocca, D., Noel, P., Omarov, T., Palermo, M., Parmar, C., Pazouki, A., Poggi, L., Poghosyan, T., Pompa, L., Ponce, J., Pournaras, D., Prasad, A., Alqahtani, A., Ramos, A., Rezvani, M., Rheinwalt, K., Ribeiro, R., Rotundo, A., Ruiz-Ucar, E., Safadi, B., Sakran, N., Salminen, P., Schroeder, O., Seki, Y., Shabbir, A., Shahabi Shahmiri, S., Shikora, S., Stein, J., Stenberg, E., Taskin, E., Torres, A., Villalonga, R., Weiner, R., Weiner, S., Yang, W., Zehetner, J., Zundel, N., Boskoski I. (ORCID:0000-0001-8194-2670), and Musella M.

Abstract

Objective: This study aimed to survey international experts in metabolic and bariatric surgery (MBS) to improve and consolidate perioperative interventions to prevent gastroesophageal reflux disease (GERD) and marginal ulcers (MU) after MBS. Background: Very important long-term complications after MBS include GERD, Barrett’s esophagus, and MU. Prevention might be fundamental to reduce the incidence, severe complications, and the increasing number of revisional bariatric surgeries. Methods: An international scientific team designed an online confidential questionnaire with 45 multiple-choice questions. The survey was sent to 110 invited experts and 96 of them (from 41 different countries) participated from 21 July 2022 to 4 September 2022. Results: Most experts (≥ 90%) prescribe postoperative acid suppression agents after MBS. Life-long proton pump inhibitors prophylaxis in smokers with avoidance of non-steroidal anti-inflammatory drugs are recommended by most of the experts (66%, 73%) after any type of gastric bypass. Two-thirds of experts (69%) perform Helicobacter pylori eradication prior to MBS. Two-thirds of experts (68%) routinely perform EGD and biopsy before MBS. Follow-up esophagogastroduodenoscopy (EGD) and timing threshold for revisional and conversional MBS were variable among experts. Conclusion: This expert survey underlines important perioperative interventions that reached a two-thirds consensus among MBS international experts. Variability in follow-up EGD, approach to complication management, and thresholds for revisional and conversional MBS emphasize the need for further researches and consensus guidelines. Graphical Abstract: [Figure not available: see fulltext.].

Published
2023

21. Nebennierentumoren

Author

Niederle, B., Prager, G., Kaserer, K., Kurtaran, A., Heinz-Peer, G., Vierhapper, H., Hiddemann, Wolfgang, Huber, Heinz, and Bartram, Claus R.

Published
2004
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28. Topic: Inguinal Hernia — Unsolved problem in the daily practice

Author

Yasuo, S., Kenichi, Y., Ueno, N., Arimoto, A., Hosono, M., Yoshikawa, T., Toyokawa, A., Kakeji, Y., Tsai, Y., Tsai, C., Sul, J., Lim, M., Park, J., Jang, C. E., Santilli, O., Tripoloni, D., Santilli, H., Nardelli, N., Greco, A., Estevez, M., Sakurai, S., Ryu, S., Cesana, G., Ciccarese, F., Uccelli, M., Grava, G., Castello, G., Carrieri, D., Legnani, G., Olmi, S., Naito, M., Yamamoto, H., Sawada, Y., Mandai, Y., Asano, H., Ino, H., Tsukuda, K., Nagahama, T., Ando, M., Ami, K., Arai, K., Miladinovic, M., Kitanovic, A., Lechner, M., Mayer, F., Meissnitzer, M., Fortsner, R., Öfner, D., Köhler, G., Jäger, T., Kumata, Y., Fukushima, R., Inaba, T., Yaguchi, Y., Horikawa, M., Ogawa, E., Katayama, T., Kumar, P. S., Unal, D., Caparlar, C., Akkaya, T., Mercan, U., Kulacoglu, H., Barreiro, J. Jorge, Baer, I. García, García, L. Solar, Cumplido, P. Lora, Florez, L. J. García, Muñiz, P. Fernandez, Fujino, K., Mita, K., Ohta, E., Takahashi, K., Hashimoto, M., Nagayasu, K., Murabayashi, R., Asakawa, H., Koizumi, K., Hayashi, G., Ito, H., Felberbauer, F., Strobl, S., Kristo, I., Riss, S., Prager, G., El Komy, H., El Gendi, A., Nabil, W., Karam, M., El Kayal, S., Chihara, N., Suzuki, H., Watanabe, M., Uchida, E., Chen, T., Wang, J., Wang, H., Bouchiba, N., Elbakary, T., Ramadan, A., Elakkad, M., Berney, C., Vlasov, V., Babii, I., Pidmurnyak, O., Prystupa, M., Asakage, N., Molinari, P., Contino, E., Guzzetti, L., Oggioni, M., Sambuco, M., Berselli, M., Farassino, L., Cocozza, E., Crespi, A., Ambrosoli, A., and Zhao, Y.

Published
2015
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29. P-5 Phase II study (daNIS-1) of the anti-TGF-β monoclonal antibody (mAb) NIS793 +/- spartalizumab in combination with nab-paclitaxel/gemcitabine (NG) versus NG alone in patients with first-line metastatic pancreatic ductal adenocarcinoma (mPDAC)

Author

Sivakumar, S., primary, Macarulla, T., additional, Grell, P., additional, Chee, C., additional, Krishnamurthy, A., additional, Ka Wong, M., additional, Michael, M., additional, Milella, M., additional, Prager, G., additional, Springfeld, C., additional, Collignon, J., additional, Siveke, J., additional, Santoro, A., additional, Lin, C., additional, Peltola, K., additional, Bostel, G., additional, Jankovic, D., additional, Altzerinakou, M., additional, Fabre, C., additional, and Bai, L., additional

Published
2022
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30. SO-16 FIRE-4 (AIO-KRK-0114): Randomized study for a switch maintenance concept with 5-FU plus bevacizumab after induction treatment with FOLFIRI plus cetuximab versus continued treatment with FOLFIRI plus cetuximab – secondary endpoint

Author

Heinemann, V., primary, Fischer von Weikersthal, L., additional, Fuchs, M., additional, Kaiser, F., additional, Heinrich, K., additional, Modest, D., additional, Hofheinz, R., additional, Decker, T., additional, Gerger, A., additional, Angermeier, S., additional, Rumpold, H., additional, Dickhut, A., additional, Öhler, L., additional, Grünberger, B., additional, Niedersüß-Beke, D., additional, Sandmann, M., additional, Kasper, S., additional, Prager, G., additional, and Stintzing, S., additional

Published
2022
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31. P-7 Encorafenib and cetuximab in patients with metastatic, BRAF V600E-mutated, colorectal cancer: Update on the first real-world study in Germany and Austria – BERING CRC

Author

von der Heyde, E., primary, Bürkle, D., additional, Forstbauer, H., additional, Hübner, G., additional, Schmidt, B., additional, Schröder, J., additional, Distelrath, A., additional, Wierecky, J., additional, Stübs, P., additional, Kisro, J., additional, Welslau, M., additional, Müller-Huesmann, H., additional, Göhler, T., additional, Krammer-Steiner, B., additional, Schwaner, I., additional, Hering-Schubert, C., additional, Gerger, A., additional, Greil, R., additional, Jacobasch, L., additional, Reichenbach, F., additional, Stintzing, S., additional, and Prager, G., additional

Published
2022
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33. Der Effekt gastrischer Elektrostimulation mittels des TANTALUS™-Systems auf Körpergewicht und Stoffwechseleinstellung bei morbid adipösen Typ 2 Diabetikern — erste Ergebnisse

Author

Schramm, M., Jung, R., Weiner, R., Rosak, C., Bohdjalian, A., Schindler, K., Prager, G., Ludvik, B., Bruch, H. P., editor, Büchler, M. W., editor, Buhr, H. J., editor, Hohenberger, W., editor, Klar, E., editor, Kremer, B., editor, Post, S., editor, Schilling, M., editor, Schumpelick, V., editor, Siewert, J. R., editor, Thiede, A., editor, Becker, H., editor, Bittner, R., editor, Függer, R., editor, Köckerling, F., editor, Saeger, H. D., editor, Zornig, C., editor, Hölscher, A., editor, Izbicki, J. R., editor, Junginger, T., editor, Senninger, N., editor, Allgayer, H., editor, Broll, R., editor, Bruns, C. J., editor, Fries, H., editor, Kalthoff, H., editor, Schackert, H. K., editor, Ertel, W., editor, Faist, E., editor, Holzheimer, R. G., editor, Holzmann, B., editor, Schade, U. F., editor, Vollmar, B., editor, Brückner, U. B., editor, Heidecke, C. D., editor, Menger, M. D., editor, Neugebauer, E., editor, Spiegel, H. U., editor, Biemer, E., editor, Germann, G., editor, Haas, N., editor, Machens, H. G., editor, Stark, G. B., editor, Steinau, H. U., editor, Haverich, A., editor, Heberer, M., editor, Rogiers, X., editor, Jauch, K. W., editor, Roth, H., editor, von Schweinitz, D., editor, Waag, K. L., editor, Altendorf-Hofmann, A., editor, Celik, I., editor, Lehnert, T., editor, Lorenz, W., editor, Ohmann, C., editor, Bechstein, W. O., editor, Broelsch, C., editor, Hopt, U., editor, Klempnauer, J., editor, Neuhaus, P., editor, Fändrich, F., editor, Markus, B., editor, Minor, T., editor, Wonigeit, K., editor, Dralle, H., editor, Goretzki, P. E., editor, Rothmund, M., editor, Bühren, V., editor, Josten, C., editor, Muhr, G., editor, Nast-Kolb, D., editor, Stürmer, K. M., editor, Trentz, O., editor, Brunkwall, J., editor, Sandmann, W., editor, Schmitz-Rixen, T., editor, Storck, M., editor, Branscheid, D., editor, Dienemann, H., editor, Hirner, A., editor, Passlick, B., editor, Toomes, H., editor, Beyersdorf, F., editor, Hetzer, R., editor, Schäfers, H. J., editor, Zerkowski, H. R., editor, Becker, H. D., editor, Saeger, H. -D., editor, Jauch, K. -W., editor, and Bauer, H., editor

Published
2006
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34. Journal update monthly top five

Author

Shanahan, T.A.G., Cottey, L., Darbyshire, D., Hirst, R., Naquib, M., Oliver, G., Prager, G., Shanahan, T.A.G., Cottey, L., Darbyshire, D., Hirst, R., Naquib, M., Oliver, G., and Prager, G.

Published
2022

37. Prevalence of anxiety and depression in people with different types of cancer or haematologic malignancies: a cross-sectional study

Author

Zeilinger, E. L., primary, Oppenauer, C., additional, Knefel, M., additional, Kantor, V., additional, Schneckenreiter, C., additional, Lubowitzki, S., additional, Krammer, K., additional, Popinger, C., additional, Kitta, A., additional, Kum, L., additional, Adamidis, F., additional, Unseld, M., additional, Masel, E. K., additional, Füreder, T., additional, Zöchbauer-Müller, S., additional, Bartsch, R., additional, Raderer, M., additional, Prager, G., additional, Krauth, M. T., additional, Sperr, W. R., additional, Porpaczy, E., additional, Staber, P. B., additional, Valent, P., additional, and Gaiger, A., additional

Published
2022
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46. AXL is a predictor of poor survival and of resistance to anti-EGFR therapy in RAS wild-type metastatic colorectal cancer

Author

Cardone C., Blauensteiner B., Moreno-Viedma V., Martini G., Simeon V., Vitiello P. P., Ciardiello D., Belli V., Matrone N., Troiani T., Morgillo F., Zito Marino F., Dentice M., Nappi A., Boccaccino A., Antoniotti C., Cremolini C., Pietrantonio F., Prager G. W., Normanno N., Maiello E., Argiles G., Elez E., Signoriello G., Franco R., Falcone A., Tabernero J., Sibilia M., Ciardiello F., Martinelli E., ZITO MARINO, Federica, Cardone, Claudia, Blauensteiner, Bernadette, Moreno-Viedma, Veronica, Martini, Giulia, Simeon, Vittorio, Vitiello, Pietro P, Ciardiello, Davide, Belli, Valentina, Matrone, Nunzia, Troiani, Teresa, Morgillo, Floriana, Zito Marino, Federica, Dentice, Monica, Nappi, Annarita, Boccaccino, Alessandra, Antoniotti, Carlotta, Cremolini, Chiara, Pietrantonio, Filippo, Prager, Gerald W, Normanno, Nicola, Maiello, Evaristo, Argiles, Guillem, Elez, Elena, Signoriello, Giuseppe, Franco, Renato, Falcone, Alfredo, Tabernero, Josep, Sibilia, Maria, Ciardiello, Fortunato, Martinelli, Erika, Cardone, C., Blauensteiner, B., Moreno-Viedma, V., Martini, G., Simeon, V., Vitiello, P. P., Ciardiello, D., Belli, V., Matrone, N., Troiani, T., Morgillo, F., Zito Marino, F., Dentice, M., Nappi, A., Boccaccino, A., Antoniotti, C., Cremolini, C., Pietrantonio, F., Prager, G. W., Normanno, N., Maiello, E., Argiles, G., Elez, E., Signoriello, G., Franco, R., Falcone, A., Tabernero, J., Sibilia, M., Ciardiello, F., Martinelli, E., and ZITO MARINO, Federica

Subjects
0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, Colorectal cancer, Population, 03 medical and health sciences, Mice, 0302 clinical medicine, Growth factor receptor, Internal medicine, Cell Line, Tumor, Proto-Oncogene Proteins, Medicine, Animals, Humans, Epithelial–mesenchymal transition, Neoplasm Metastasis, education, education.field_of_study, Cetuximab, business.industry, AXL, EGFR resistance, RAS WT, Receptor Protein-Tyrosine Kinases, Transfection, medicine.disease, Xenograft Model Antitumor Assays, Axl Receptor Tyrosine Kinase, Blockade, ErbB Receptors, 030104 developmental biology, Genes, ras, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Immunohistochemistry, business, Colorectal Neoplasms, Biomarkers, medicine.drug
Abstract

Background RAS mutations are the only validated biomarkers in metastatic colorectal cancer (mCRC) for anti-epidermal growth factor receptor (EGFR) therapy. Limited clinical information is available on AXL expression, marker of epithelial to mesenchymal transition, in mCRC. Methods AXL was retrospectively assessed by immunohistochemistry in 307 patients. RAS wild-type (WT) patients (N = 136) received first-line anti-EGFR–based therapy; RAS mutant patients (N = 171) received anti-angiogenic–based regimens. Preclinical experiments were performed using human RAS WT CRC cell lines and xenograft models. AXL RNA levels were assessed in a cohort of patients with available samples at baseline and at progression to anti-EGFR treatment and in the GSE5851 dataset. Results AXL was expressed in 55/307 tumour tissues, correlating with worse survival in the overall population (AXL-positive, 23.7 months; AXL-negative, 30.8 months; HR, 1.455, P = 0.032) and in RAS WT patients (AXL-positive, 23.0 months; AXL-negative, 35.8 months; HR,1.780, P = 0.032). Progression-free survival (PFS) in the RAS WT cohort was shorter in the AXL-positive cohort (6.2 months versus 12.1 months; HR, 1.796, P = 0.013). Three-dimensional cultures obtained from a patient following anti-EGFR therapy resulted AXL-positive, showing resistance to anti-EGFR drugs and sensitivity to AXL inhibition. AXL transfection in CRC cell lines induced AXL overexpression and resistance to the EGFR blockade. At progression to cetuximab, 2/10 SW48-tumour xenograft mice showed AXL expression. Consistently, AXL RNA levels increased in 5/7 patients following anti-EGFR therapy. Moreover, in the GSE5851 dataset higher AXL RNA levels correlated with worse PFS with cetuximab in KRAS-exon2 WT chemorefractory patients. Conclusions AXL is a marker of poor prognosis in mCRC with consistent clinical and preclinical evidences of involvement in primary and acquired resistance to anti-EGFR drugs in RAS WT patients.

Published
2020

47. IFSO (International Federation for Surgery of Obesity and Metabolic Disorders) Consensus Conference Statement on One-Anastomosis Gastric Bypass (OAGB-MGB): Results of a Modified Delphi Study

Author

Ramos A. C., Chevallier J. -M., Mahawar K., Brown W., Kow L., White K. P., Shikora S., Zeid M. A., Al Sabah S., Antozzi P., Bashah M., Bashir A., Behrens E., Bhandari M., Bottino A., Carbajo M., da Silva L. E., De Luca M., DeMaria E., ElFawal M. H., Fobi M. A. L., Gari M. K. M., Hargroder D. E., Herrera G., Higa K., Himpens J., Jammu G. S., Khammas A., Kular K. S., Lakdawala M., Layani L., Luque-de-Leon E., Musella M., Pacheco F., Parmar C., Peraglie C., Prager G., Prasad A., Rheinwalt K. P., Ribeiro R., Robert M., Rosenthal R., Safadi B., Sakran N., Shabbir A., Small P. K., Suter M., Taha O., Taylor C., Verboonen S., Wang C., Weiner R., Williams N., Ramos, A. C., Chevallier, J. -M., Mahawar, K., Brown, W., Kow, L., White, K. P., Shikora, S., Zeid, M. A., Al Sabah, S., Antozzi, P., Bashah, M., Bashir, A., Behrens, E., Bhandari, M., Bottino, A., Carbajo, M., da Silva, L. E., De Luca, M., Demaria, E., Elfawal, M. H., Fobi, M. A. L., Gari, M. K. M., Hargroder, D. E., Herrera, G., Higa, K., Himpens, J., Jammu, G. S., Khammas, A., Kular, K. S., Lakdawala, M., Layani, L., Luque-de-Leon, E., Musella, M., Pacheco, F., Parmar, C., Peraglie, C., Prager, G., Prasad, A., Rheinwalt, K. P., Ribeiro, R., Robert, M., Rosenthal, R., Safadi, B., Sakran, N., Shabbir, A., Small, P. K., Suter, M., Taha, O., Taylor, C., Verboonen, S., Wang, C., Weiner, R., and Williams, N.

Subjects
medicine.medical_specialty, Empirical data, Statement (logic), Endocrinology, Diabetes and Metabolism, media_common.quotation_subject, education, Gastric bypass, Modified delphi, 030209 endocrinology & metabolism, Anastomosis, Delphi, One-anastomosis gastric bypass, 03 medical and health sciences, 0302 clinical medicine, Voting, medicine, Obesity, Mini-gastric bypa, media_common, Nutrition and Dietetics, business.industry, Consensus conference, medicine.disease, Surgery, Consensus statement, 030211 gastroenterology & hepatology, business
Abstract

Background: One-anastomosis gastric bypass (OAGB-MGB) is currently the third performed primary bariatric surgical procedure worldwide. However, the procedure is hampered by numerous controversies and there is considerable variability in surgical technique, patient selection, and pre- and postoperative care among the surgeons performing this procedure. This paper reports the results of a modified Delphi consensus study organized by the International Federation for Surgery of Obesity and Metabolic Disorders (IFSO). Methods: Fifty-two internationally recognized bariatric experts from 28 countries convened for voting on 90 consensus statements over two rounds to identify those on which consensus could be reached. Inter-voter agreement of ≥ 70% was considered consensus, with voting participation ≥ 80% considered a robust vote. Results: At least 70% consensus was achieved for 65 of the 90 questions (72.2% of the items), 61 during the first round of voting and an additional four in the second round. Where consensus was reached on a binary agree/disagree or yes/no item, there was agreement with the statement presented in 53 of 56 instances (94.6%). Where consensus was reached on a statement where options favorable versus unfavorable to OAGB-MGB were provided, including statements in which OAGB-MGB was compared to another procedure, the response option favorable to OAGB-MGB was selected in 13 of 23 instances (56.5%). Conclusion: Although there is general agreement that the OAGB-MGB is an effective and usually safe option for the management of patients with obesity or severe obesity, numerous areas of non-consensus remain in its use. Further empirical data are needed.

Published
2020

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