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Processing musical meter—the organization of time into regular cycles of strong and weak beats—requires abstraction from the varying rhythmic surface. Several studies have investigated whether meter processing requires attention, or if it can be both pre-attentive and attentive. While findings on temporal expectation (processing meter per se) indicate benefits of attention, studies on meter processing in complex, dual-task contexts (meter used for temporal orientation) consistently report pre-attentive processing. Also, while surface-based approaches to meter (meter aided by pattern repetition) show some benefits of attention, structural approaches (meter not aided by pattern repetition, increased complexity) find pre-attentive-only processing. Therefore, in the present study, we hypothesized that pre-attentive processing increases with cognitive load, and we compared surface with structural meter processing. Supporting our hypothesis, we saw improved behavioral performance for surface meter, as well as electroencephalogram (EEG) evidence that structural meter elicits pre-attentive processing while surface meter does not. Our findings highlight the need for increased awareness in approaches to meter processing and support the idea that increased cognitive demand may recruit pre-attentive processing of temporal structure. At the practical level, our findings suggest that focusing listeners' attention on meter, for example, when practicing dance, may not increase their understanding of meter structure. [ABSTRACT FROM AUTHOR]

The neutral tone is a unique tone form in Mandarin as it distinguishes from four canonical tones or full tones on the one hand and integrates phonetic, morphological, syntactical and prosodic information on the other hand. Research to date has been focusing on its unique and variant acoustic features. However, little is known about how native Mandarin speakers process such a unique tone. In the present study, the mismatch negativity was used to explore the comparison-based pre-attentive change detection of Mandarin neutral tone. The mismatch negativity at the time window of 400-800 ms post-first-tone onset was obtained by subtracting event-related potentials to standard neutral tone from event-related potentials to a deviant natural tone. The source analysis of mismatch negativity showed the cortex generator was located at the left temporal lobe. The data suggest that Chinese native speakers process neutral tone automatically under non-attentional conditions, as revealed by the mismatch negativity data aligned with a neutral tone, and that neutral tone does exist as an automatically recognizable one in native Mandarin speakers’ tone system.

The auditory mismatch negativity, a component of the event-related potential elicited by an unexpected stimulus in a sequence of acoustic stimuli, provides an objective measure of the accuracy of the echoic information processing of the human brain in vivo. Auditory mismatch negativity is also a useful probe of cortical glutamatergic N-methyl-d-aspartate receptor activity and disturbance. Notably, auditory mismatch negativity is consistently impaired in schizophrenia. Because of the wide spectrum extending from bipolar affective illness and schizoaffective psychosis to typical schizophrenia, we examined the literature on auditory mismatch negativity in bipolar disorder with the aim to find any neurophysiological dysfunction concerning pre-attentive information processing shared by these clinical conditions. This focused review includes 26 original articles published in peer-reviewed journals and indexed in the National Institutes of Health National Library of Medicine (PubMed) search system. Overall, evidence is consistent with the finding that auditory mismatch negativity is impaired in bipolar disorder with psychotic features, even though to a lesser extent than in schizophrenia. It must be acknowledged that, in a few twin and family studies, mismatch negativity abnormalities were not specifically associated with bipolar disorder. In conclusion, auditory mismatch negativity research supports the involvement of the N-methyl-d-aspartate system in the pathophysiology of bipolar disorder, as previously assessed for schizophrenia, thus creating an intriguing trait d'union between these two mental illnesses and stimulating the development of novel therapeutic agents. With additional replication and validation, auditory mismatch negativity may be further considered as a correlate of a common psychopathology of schizophrenia and bipolar spectrum illnesses. [ABSTRACT FROM AUTHOR]

In the present study we investigated expert and novice football (i.e., soccer) goalkeepers' three stages of perceiving changes in open play situations—detection, localization, and identification—with and without time constraints. We adopted the continual cycling flicker paradigm to investigate goalkeepers' perceptions when provided with sufficient time (Experiment 1), and we utilized the limited display one-shot change detection paradigm to study their perceptions under time constraints (Experiment 2). Images of goalkeepers' first-person views of open play soccer scenes were used as stimuli. Semantic or non-semantic changes in these scenes were produced by modifying one element in each image. Separate groups of expert and novice goalkeepers were required to detect, localize, and identify the scene changes. We found that expert goalkeepers detected scene changes more quickly than novices under both time allowances. Furthermore, compared to novices, experts localized the changes more accurately under time constraints and identified the changes more quickly when given sufficient time. Additionally, semantic changes were detected more quickly and localized and identified more accurately than non-semantic changes when there was sufficient time. Under time constraints expert goalkeepers' greater efficiency was likely due to pre-attentive processing; with sufficient time, they were able to focus attention to extracting detailed information for identification. [ABSTRACT FROM AUTHOR]

Renjun Lv,1– 5 Shanjing Nie,1– 4 Zhenhua Liu,6 Yunliang Guo,1– 4 Yue Zhang,7 Song Xu,1– 4 Xunyao Hou,1– 4 Jian Chen,1– 4 Yingjuan Ma,8 Zhongyu Fan,1– 5 Xueping Liu1– 4 1Department of Geriatrics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, Shandong, People’s Republic of China; 2Department of Geriatric Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, Shandong, People’s Republic of China; 3Anti-Aging Monitoring Laboratory, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, Shandong, People’s Republic of China; 4Department of Anti-Aging, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, Shandong, People’s Republic of China; 5Shandong Provincial Hospital, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250021, Shandong, People’s Republic of China; 6Center of Sleep Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, Shandong, People’s Republic of China; 7Department of Geriatric Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, People’s Republic of China; 8Department of Otolaryngology Head and Neck Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, People’s Republic of ChinaCorrespondence: Xueping Liu Tel +86-53168777165Email Liuxueping1962@163.comAim: Obstructive sleep apnea syndrome (OSAS) is a prevalent chronic disease characterized by sleep fragmentation and intermittent hypoxemia. Several studies suggested that electrophysiological changes and neurocognitive abnormalities occurred in OSAS patients. In this study, we compared automatic processing of emotional facial expressions schematic in OSAS patients and matched healthy controls via assessing expression-related mismatch negativity (EMMN).Methods: Twenty-two OSAS patients (mean age 44.59 years) and twenty-one healthy controls (mean age 42.71 years) were enrolled in this study. All participants underwent Montreal Cognitive Assessment (MoCA) scale test and polysomnographic recording. An expression-related oddball paradigm was used to elicit EMMN and the electroencephalogram was recorded and analyzed. Furthermore, Pearson’s correlations were calculated to discuss the correlation between neuropsychological test scores, clinical variables and electrophysiological data.Results: Compared with healthy controls, OSAS sufferers demonstrated significantly reduced EMMN mean amplitudes within corresponding time intervals, regardless of happy or sad conditions. Meanwhile, we observed that amplitude of sad EMMN was larger (more negative) than happy EMNN in healthy controls, while not in patients. Moderate correlations were found between MoCA test scores, sleep parameters and EMMN amplitudes.Conclusion: Our findings suggested pre-attentive dysfunction of processing emotional facial expressions in patients with OSAS, without the existence of negative bias effect. Moreover, correlation analysis showed that clinical characteristics of OSAS patients could affect EMMN amplitudes. Further studies on the advantages of EMMN as clinical and electrophysiological indicators of OSAS are warranted.Keywords: OSAS, EMMN, facial expressions, pre-attentive processing, negative bias effect

Background. The paper considers the issue of categorical search for three-dimensional geometric shapes. The results of the previous studies on the real-world objects showed that pre-attentive extrafoveal analysis provides an effective identification of the target, reflecting in the right direction of the first saccade compared with the random search. Objective. In this study, we investigated the efficacy of extrafoveal analysis during categorical search for pyramids in two groups of participants: mathematicians and psychologists. Design. 15 mathematicians and 17 psychologists aged 18-25 participated in the study. Each participant performed 144 trialssearching for the target pyramid among the distractor pyramids. In the series 2and 9, any eye movements were prohibited to study covert attention. Results. The findings of the experiment failed to reveal any differences in the use of extrafoveal analysis and accuracy in both groups. We observed dramatic individual differences, revealed in various degrees of extrafoveal analysis in the search process and in changing the strategy of the task solving. Special series which prohibited eye movements, demonstrated a significant role of covert attention in the categorical search, as well as the possibility and effectiveness of extrafoveal analysis even though while free instruction it could not be used by all participants and all cases. Conclusion. During categorical search both foveal and extrafoveal processing of stimuli, as well as pre-attentive analysis and covert attention, were simultaneously involved. The dynamics of their interaction was determined by low-level perceptual processes, individual characteristics of the subjects, the task specificity and the instruction.

Speech comprehension across languages depends on encoding the pitch variations in frequency-modulated (FM) sweeps at different timescales and frequency ranges. While timescale and spectral contour of FM sweeps play important roles in differentiating acoustic speech units, relatively little work has been done to understand the interaction between the two acoustic dimensions at early cortical processing. An auditory oddball paradigm was employed to examine the interaction of timescale and pitch contour at pre-attentive processing of FM sweeps. Event-related potentials to frequency sweeps that vary in linguistically relevant pitch contour (fundamental frequency F0 vs. first formant frequency F1) and timescale (local vs. global) in Mandarin Chinese were recorded. Mismatch negativities (MMNs) were elicited by all types of sweep deviants. For local timescale, FM sweeps with F0 contours yielded larger MMN amplitudes than F1 contours. A reversed MMN amplitude pattern was obtained with respect to F0/F1 contours for global timescale stimuli. An interhemispheric asymmetry of MMN topography was observed corresponding to local and global-timescale contours. Falling but not rising frequency difference waveforms sweep contours elicited right hemispheric dominance. Results showed that timescale and pitch contour interacts with each other in pre-attentive auditory processing of FM sweeps. Findings suggest that FM sweeps, a type of non-speech signal, is processed at an early stage with reference to its linguistic function. That the dynamic interaction between timescale and spectral pattern is processed during early cortical processing of non-speech frequency sweep signal may be critical to facilitate speech encoding at a later stage.

Speech comprehension across languages depends on encoding the pitch variations in frequency-modulated (FM) sweeps at different timescales and frequency ranges. While timescale and spectral contour of FM sweeps play important roles in differentiating acoustic speech units, relatively little work has been done to understand the interaction between the two acoustic dimensions at early cortical processing. An auditory oddball paradigm was employed to examine the interaction of timescale and pitch contour at pre-attentive processing of FM sweeps. Event-related potentials to frequency sweeps that vary in linguistically relevant pitch contour (fundamental frequency F0 vs. first formant frequency F1) and timescale (local vs. global) in Mandarin Chinese were recorded. Mismatch negativities (MMNs) were elicited by all types of sweep deviants. For local timescale, FM sweeps with F0 contours yielded larger MMN amplitudes than F1 contours. A reversed MMN amplitude pattern was obtained with respect to F0/F1 contours for global timescale stimuli. An interhemispheric asymmetry of MMN topography was observed corresponding to local and global-timescale contours. Falling but not rising frequency difference waveforms sweep contours elicited right hemispheric dominance. Results showed that timescale and pitch contour interacts with each other in pre-attentive auditory processing of FM sweeps. Findings suggest that FM sweeps, a type of non-speech signal, is processed at an early stage with reference to its linguistic function. That the dynamic interaction between timescale and spectral pattern is processed during early cortical processing of non-speech frequency sweep signal may be critical to facilitate speech encoding at a later stage. [ABSTRACT FROM AUTHOR]

Purpose: According to the cognitive processing perspectives, patients with insomnia have insufficient neural management of expressional information. In this study, we compared the pre-attentive processing function of task-irrelevant facial expressions in patients with primary insomnia (PI) and matched healthy controls, with expression-related mismatch negativity (EMMN) elicited by emotional faces as the indicator. Methods: Using three schematic facial expressions (neutral, happy, and sad) as task-irrelevant stimuli, we investigated the visual processing of PI patients (n = 22) and healthy subjects (n = 22) in an expression-related oddball paradigm designed to elicit the visual N170 and EMMN component. After recording and analyzing the electroencephalogram of all participants, amplitude analysis of N170 and EMMN was eventually conducted under corresponding time window. Results: Compared with control group, the amplitude of sad-EMMN component was significantly attenuated in patients with PI, while no remarkable difference was observed under the happy condition. In addition, negative cognitive bias was further validated in the control group, but not presented in the PI group. Conclusion: The current data suggest dysfunctional expressional information processing in PI patients, accompanied by the disorganization of high level perceptual strategy of processing facial emotional expression. [ABSTRACT FROM AUTHOR]

Women are twice as likely as men to develop depression. Few studies have explored gender difference in cognitive function of patients with MDD. The gender difference in the pre-attentive information processing of MDD patients is still poorly understood. To examine the gender differences in change detection, 30 medication-free MDD patients (15 women) and 30 age and education matched controls (15 women) were recruited. The deviant-standard reverse oddball paradigm (50 ms/150 ms) was used to obtain the visual mismatch negativity (vMMN) in first episode MDD patients. Compared to men with MDD, women with MDD showed a significantly decreased increment vMMN, while no gender difference in decrement vMMN was found. The increment vMMN amplitude in MDD women was smaller than in healthy women, whereas no difference was found in decrement vMMN. Neither increment nor decrement vMMN differed between MDD men and healthy men. The mean amplitude of increment vMMN was not correlated with symptoms of MDD in MDD patients and MDD women. To conclude, the dysfunction of visual information processing existed at pre-attentive stage in MDD women.

Women are twice as likely as men to develop depression. Few studies have explored gender difference in cognitive function of patients with MDD. The gender difference in the pre-attentive information processing of MDD patients is still poorly understood. To examine the gender differences in change detection, 30 medication-free MDD patients (15 women) and 30 age and education matched controls (15 women) were recruited. The deviant-standard reverse oddball paradigm (50 ms/150 ms) was used to obtain the visual mismatch negativity (vMMN) in first episode MDD patients. Compared to men with MDD, women with MDD showed a significantly decreased increment vMMN, while no gender difference in decrement vMMN was found. The increment vMMN amplitude in MDD women was smaller than in healthy women, whereas no difference was found in decrement vMMN. Neither increment nor decrement vMMN differed between MDD men and healthy men. The mean amplitude of increment vMMN was not correlated with symptoms of MDD in MDD patients and MDD women. To conclude, the dysfunction of visual information processing existed at pre-attentive stage in MDD women. [ABSTRACT FROM AUTHOR]

Introduction: Startle reflex is measured by delivering a sensory stimulus and measuring eyelid closure in human beings to investigate the neurophysiology of information processing. However, the characteristics of startle reflex can be modified by weaker prepulse. Since this modification is increasingly being associated with various psychiatric disorders, it is worth exploring the prepulse modification of startle reflex. Aim: The aim of the present study was to explore the differential modulatory effect of auditory stimulus onset asynchronies on startle response magnitude as well as latency. Materials and Methods: The study was conducted on 30 healthy right handed male subjects aged 18-40 years. Auditory prepulse was delivered binaurally which was followed by startle stimuli. The startle reflex was recorded from orbicularis oculi muscle by electromyography. Inter stimulus interval was varied in different trials from 30 ms to 1000 ms. The startle reflex from different trials were later analysed for response latency and magnitude. Results: The results of the present study show that latency of the response was not different with different Stimulus Onset Synchronies (SOA’s). However, the magnitude of the response was inhibited with SOAs 60 ms, 120 ms and 250 ms while facilitated with SOA 1000 ms when compared to baseline. SOAs 30 ms and 500 ms had no effect on the response. Conclusion: Differential response to different prepulse to pulse inter stimulus interval implies that temporal presentation of stimuli is very important for priority coding. Very small SOA’s are important for priority coding of the stimulus. However, with much larger SOA’s, the first stimulus serves as an orienting response for the next stimulus.

Sex differences in conscious emotional processing represent a well-known phenomenon. The present event-related potential (ERP) study examined sex differences in the automatic change detection of facial expressions, as indexed by the visual mismatch negativity (vMMN). As paid volunteers, 19 females and 19 males were presented peripherally with a passive emotional oddball sequence in a happy-neutral context and a fearful-neutral context while they performed a visual detection task in the center of the visual field. Both females and males showed comparable accuracy rates and reaction times in the primary detection task. Females relative to males showed a larger P1 for all facial expressions, as well as a more negative N170 and a less positive P2 for deviants vs. standards. During the early stage (100–200 ms), females displayed more negative vMMN responses to both happy and neutral faces than males over the occipito-temporal and fronto-central regions. During the late stage (250–350 ms), females relative to males exhibited more negative vMMN responses to both happy and neutral faces over the fronto-central and right occipito-temporal regions, but only more negative vMMN responses to happy faces over the left occipito-temporal region. In contrast, no sex differences were found for vMMN responses in the fearful-neutral context. These findings indicated a female advantage dynamically in the automatic neural processing of facial expressions during a happy-neutral context.

Sex differences in conscious emotional processing represent a well-known phenomenon. The present event-related potential (ERP) study examined sex differences in the automatic change detection of facial expressions, as indexed by the visual mismatch negativity (vMMN). As paid volunteers, 19 females and 19 males were presented peripherally with a passive emotional oddball sequence in a happy-neutral context and a fearful-neutral context while they performed a visual detection task in the center of the visual field. Both females and males showed comparable accuracy rates and reaction times in the primary detection task. Females relative to males showed a larger P1 for all facial expressions, as well as a more negative N170 and a less positive P2 for deviants vs. standards. During the early stage (100-200 ms), females displayed more negative vMMN responses to both happy and neutral faces than males over the occipito-temporal and fronto-central regions. During the late stage (2500350 ms), females relative to males exhibited more negative vMMN responses to both happy and neutral faces over the fronto-central and right occipito-temporal regions, but only more negative vMMN responses to happy faces over the left occipito-temporal region. In contrast, no sex differences were found for vMMN responses in the fearful-neutral context. These findings indicated a female advantage dynamically in the automatic neural processing of facial expressions during a happy-neutral context. [ABSTRACT FROM AUTHOR]

Introduction: Startle reflex is measured by delivering a sensory stimulus and measuring eyelid closure in human beings to investigate the neurophysiology of information processing. However, the characteristics of startle reflex can be modified by weaker prepulse. Since this modification is increasingly being associated with various psychiatric disorders, it is worth exploring the prepulse modification of startle reflex. Aim: The aim of the present study was to explore the differential modulatory effect of auditory stimulus onset asynchronies on startle response magnitude as well as latency. Materials and Methods: The study was conducted on 30 healthy right handed male subjects aged 18-40 years. Auditory prepulse was delivered binaurally which was followed by startle stimuli. The startle reflex was recorded from orbicularis oculi muscle by electromyography. Inter stimulus interval was varied in different trials from 30 ms to 1000 ms. The startle reflex from different trials were later analysed for response latency and magnitude. Results: The results of the present study show that latency of the response was not different with different Stimulus Onset Synchronies (SOA's). However, the magnitude of the response was inhibited with SOAs 60 ms, 120 ms and 250 ms while facilitated with SOA 1000 ms when compared to baseline. SOAs 30 ms and 500 ms had no effect on the response. Conclusion: Differential response to different prepulse to pulse inter stimulus interval implies that temporal presentation of stimuli is very important for priority coding. Very small SOA's are important for priority coding of the stimulus. However, with much larger SOA's, the first stimulus serves as an orienting response for the next stimulus. [ABSTRACT FROM AUTHOR]

Negative bias in cognition is closely associated with susceptibility to recurrent episodes of depression. Given the high recurrence rate of depression, previous studies have focused on the attentive level in late-life depression (LLD), but depression relapse is difficult to detect as a lower chief complaint in elderly people. Facial expression mismatch negativity (EMMN) is a tool that can measure cognitive bias in pre-attentive processing. In this study, we sought to explore the cognitive bias in pre-attentive emotional information processing in LLD. Thirty patients with remitted LLD and 30 non-depressed, age- and gender-matched normal controls (NC) were enrolled in this study. Automatic emotional processing was elicited by using an expression-related oddball paradigm in all participants. There were no significant differences in N170 amplitude and latency between remitted LLD and NC. Compared with NC subjects, patients with remitted LLD demonstrated an attenuated mean amplitude of positive and negative EMMN, whereas the mean amplitude of negative EMMN in remitted LLD was much larger than that of positive EMMN. Our findings suggest that although basic processing of facial expressions is intact in remitted LLD, automatic processing of facial expressions in remitted LLD is impaired with a negative bias in cognition. Further investigation of the contributions of negative bias in EMMN to susceptibility to recurrence of LLD is warranted. [ABSTRACT FROM AUTHOR]

Depression is associated with bias in emotional information processing, but less is known about the processing of neutral sensory stimuli. Of particular interest is processing of sound intensity which is suggested to indicate central serotonergic function. We tested weather event-related brain potentials (ERPs) to occasional changes in sound intensity can dissociate first-episode depressed, recurrent depressed and healthy control participants. The first-episode depressed showed larger N1 amplitude to deviant sounds compared to recurrent depression group and control participants. In addition, both depression groups, but not the control group, showed larger N1 amplitude to deviant than standard sounds. Whether these manifestations of sensory over-excitability in depression are directly related to the serotonergic neurotransmission requires further research. The method based on ERPs to sound intensity change is fast and low-cost way to objectively measure brain activation and holds promise as a future diagnostic tool. [ABSTRACT FROM AUTHOR]

Background: Deficits of pre-attentive information processing have been frequently found in patients with major depressive disorder, nevertheless the results are quite inconsistent due to clinical heterogeneity and methodological difference. Cognitive processing of music is a useful tool for investigating human cognition and its underlying brain mechanisms. Although general auditory processing and perception of musical sound are hampered in patients with MDD, whether the deficits in musical processing begin from pre-attentive stage is not well investigated yet. The present study aimed to investigate the MMN of musical sound in patients with MDD.Method: MMN responses to different musical features were compared in 20 patients with MDD and 20 age-matched healthy controls. The multi-feature paradigm was used to examine automatic change detection of six different musical sound features (pitch, timbre, location, intensity, slide, rhythm) in a complex musical context. Severity of depression and co-morbid anxiety were evaluated using the Hamilton Rating Scale of Depression (HRSD-17) and the Hamilton Anxiety Rating Scale (HAMA).Results: MMNs were obtained with all deviants. The timbre-MMN was significantly larger in MDD patients than in healthy controls, while the other deviants (pitch, location, intensity, slide and rhythm) elicited similar MMN across groups. For MDD patients, the amplitudes and latencies of MMNs did not correlate with severity of depression or co-morbid anxiety.Limitations: The sample size in this study is relatively small.Conclusion: Patients with MDD do not perform at the same level as controls in automatic change detection of timbre. This dysfunction is considered to be a trait-dependent feature of MDD. [ABSTRACT FROM AUTHOR]

Objective: Despite ongoing debate about gender differences in pre-attention processes, little is known about gender effects on change detection for auditory and visual stimuli. We explored gender differences in change detection while processing duration information in auditory and visual modalities. Method: We investigated pre-attentive processing of duration information using a deviant-standard reverse oddball paradigm (50 ms/150 ms) for auditory and visual mismatch negativity (aMMN and vMMN) in males and females (n = 21/group). Result: In the auditory modality, decrement and increment aMMN were observed at 150-250 ms after the stimulus onset, and there was no significant gender effect on MMN amplitudes in temporal or fronto-central areas. In contrast, in the visual modality, only increment vMMN was observed at 180-260 ms after the onset of stimulus, and it was higher in males than in females. Conclusion: No gender effect was found in change detection for auditory stimuli, but change detection was facilitated for visual stimuli in males. Significance: Gender effects should be considered in clinical studies of pre-attention for visual stimuli. [ABSTRACT FROM AUTHOR]

Results of a mismatch negativity experiment are reported in which the pre-attentive relevance of the German phonological alternation of final devoicing is shown in two ways. The experiment employs pseudowords. (1) A deviant [vus] paired with standard /vuzə/ did not show a mismatch effect for the voicing change in /z/ versus [s] because the two can be related by final devoicing. When standard and deviant were reversed, the two could not be related by final devoicing and a mismatch effect for the voicing difference occurred. (2) An ill-formed deviant that violates final devoicing, *[vuz], triggered mismatch effects that were plausibly attributed to its ill-formedness. The results show that a syllable-related process like final devoicing is already taken into account by the processing system in early pre-attentive processing.

Recognizing intentions of strangers from facial cues is crucial in everyday social interactions. Recent studies demonstrated enhanced event-related potential (ERP) responses to untrustworthy compared to trustworthy faces. The aim of the present study was to investigate the electrophysiological correlates of automatic processing of trustworthiness cues in a visual oddball paradigm in two consecutive experimental blocks. In one block, frequent trustworthy (p = 0.9) and rare untrustworthy face stimuli (p = 0.1) were briefly presented on a computer screen with each stimulus consisting of four peripherally positioned faces. In the other block stimuli were presented with reversed probabilities enabling the comparison of ERPs evoked by physically identical deviant and standard stimuli. To avoid attentional effects participants engaged in a central detection task. Analyses of deviant minus standard difference waveforms revealed that deviant untrustworthy but not trustworthy faces elicited the visual mismatch negativity (vMMN) component. The present results indicate that adaptation occurred to repeated unattended trustworthy (but not untrustworthy) faces, i.e., an automatic expectation was elicited towards trustworthiness signals, which was violated by deviant untrustworthy faces. As an evolutionary adaptive mechanism, the observed fast detection of trustworthiness-related social facial cues may serve as the basis of conscious recognition of reliable partners. [ABSTRACT FROM AUTHOR]

Background Mismatch negativity (MMN) and P3a components are sequential and co-occur. MMN represents the pre-attentive index of deviance detection and P3a represents the attention orienting response. Major depressive disorder (MDD) is characterized by impaired pre-attentive information processing. To assess whether impaired pre-attentive information processing can lead to an impairment of subsequent orienting process as the neurophysiological transmission spreads from MMN to P3a in MDD. Methods MMN/P3a was obtained during a two-tone auditory paradigm with 8% duration deviants in 45 first-episode major depression subjects (F-MD), 40 recurrent major depression subjects (R-MD), and 46 healthy controls (HC). Results Compared with HC, F-MD and R-MD had lower MMN amplitudes and no differences were found between F-MD and R-MD. Notably, R-MD had lower P3a amplitudes and longer P3a latencies compared to HC, while F-MD had no differences. Interestingly, no correlations were found between the severity of depression and the deficits of MMN amplitude. The deficits of P3a amplitude, however, were negatively correlated with the severity of depression in F-MD and R-MD. Furthermore, the P3a amplitude deficits were positively correlated with the number of episodes in R-MD. Limitations Patients were on antidepressant medication. Conclusions The recurrence of depressive episodes can lead to impaired pre-attentive information processing, causing an impairment of subsequent orienting process as the neurophysiological transmission from MMN to P3a. It further suggests that the impaired processing indexed by MMN amplitude may be a stable trait biomarker for the appearance of depression, while P3a amplitude can be used a potential biomarker for recurrence. [ABSTRACT FROM AUTHOR]

Results of a mismatch negativity experiment are reported in which the pre-attentive relevance of the German phonological alternation of final devoicing (FD) is shown in two ways.The experiment employs pseudowords. (1)A deviant [vus] paired with standard /vuz∂/ did not show a mismatch effect for the voicing change in /z/ versus [s] because the two can be related by FD. When standard and deviant were reversed, the two could not be related by FD and a mismatch effect for the voicing difference occurred. (2) An ill-formed deviant that violates FD, *[vuz], triggered mismatch effects that were plausibly attributed to its ill-formedness. The results show that a syllable-related process like FD is already taken into account by the processing system in early pre-attentive processing. [ABSTRACT FROM AUTHOR]

Recognizing intentions of strangers from facial cues is crucial in everyday social interactions. Recent studies demonstrated enhanced event-related potential (ERP) responses to untrustworthy compared to trustworthy faces. The aim of the present study was to investigate the electrophysiological correlates of automatic processing of trustworthiness cues in a visual oddball paradigm in two consecutive experimental blocks. In one block, frequent trustworthy (p = 0.9) and rare untrustworthy face stimuli (p = 0.1) were briefly presented on a computer screen with each stimulus consisting of four peripherally positioned faces. In the other block stimuli were presented with reversed probabilities enabling the comparison of ERPs evoked by physically identical deviant and standard stimuli. To avoid attentional effects participants engaged in a central detection task. Analyses of deviant minus standard difference waveforms revealed that deviant untrustworthy but not trustworthy faces elicited the visual mismatch negativity (vMMN) component. The present results indicate that adaptation occurred to repeated unattended trustworthy (but not untrustworthy) faces, i.e., an automatic expectation was elicited towards trustworthiness signals, which was violated by deviant untrustworthy faces. As an evolutionary adaptive mechanism, the observed fast detection of trustworthiness-related social facial cues may serve as the basis of conscious recognition of reliable partners. [ABSTRACT FROM AUTHOR]

Previous studies have reported seemingly conflicting results regarding how the amount of stimulus similarity between two simultaneously presented target stimuli impacts perceptual performance. There are many reports of ‘repetition blindness’, where individuals do worse when shown two similar stimuli relative to two different stimuli. On the other hand, there are reports of ‘similarity grouping’, where participants perform better when identifying two similar objects relative to two different objects. This manuscript posits that repetition blindness and similarity grouping coexist and can be elicited in the same subjects in a single task. This not only explains the previous opposite effects of stimulus similarity on task performance, but also provides a unique opportunity to directly compare these opposite effects of stimulus similarity with respect to susceptibility to a modulating factor. Since previous studies have provided inconclusive results on whether attentional relevance can modulate the effect of stimulus similarity on task performance, the current manuscript aims to compare repetition blindness and similarity grouping with respect to their susceptibility to attentional relevance. The results of the first experiment confirmed that both repetition blindness and similarity grouping can be elicited in the same experiment, suggesting that repetition blindness and similarity grouping coexist. The results of the second experiment suggest that both repetition blindness and similarity grouping can be modulated by attentional relevance. These results support the explanation of repetition blindness as a token individuation failure. Furthermore, these results suggest that supposedly pre-attentional grouping mechanisms might not operate as independently from top-down attentional modulations as traditionally thought.

Abstract: Individuals frequently experience mental fatigue during or after prolonged periods of cognitive activity. We investigated the effects of mental fatigue on the ability to detect minor changes in the pre-attentive stage of information processing by recoding MMN of ERP components. The equal probable paradigm was employed to elicit pure memory-comparison-based MMN component. Mental fatigue was induced by the continuous performance for 2h of mental arithmetic tasks. MMN amplitudes at fronto-central electrode sites were significantly decreased in subjects with mental fatigue than in subjects under control conditions, whereas temporal MMN was not affected by mental fatigue. These results suggest that mental fatigue impairs pre-attentive processing. [Copyright &y& Elsevier]

Abstract: This study investigated the effect of hyperthermia on pre-attentive processing by recording the mismatch negativity (MMN) component of ERPs. 36 right-handed young male undergraduates were divided into two groups, a control group with 1h of exposure at 25°C and a heat group with 1h of exposure at 50°C. MMNs were recorded before and after heat exposure. It was found that, although there was no group difference before heat exposure, MMN declined significantly in the heat group compared to the control group after heat exposure for 1h, indicating that passive heat exposure could damage pre-attentive processing. The MMN component could be a good index to assess cognitive functioning in a hot environment. [Copyright &y& Elsevier]

Sixty-four children, aged 7 to 14 years, with early-treated PKU, were compared with control children on visual evoked potential (VEP) amplitudes and latencies and auditory mismatch negativity (MMN) amplitudes. It was further investigated whether indices of dietary control would be associated with these evoked potentials parameters. There were no significant differences between controls and children with PKU in VEP- and MMN-indices. However, higher lifetime Phe levels were, in varying degree and stronger than concurrent Phe level, related to increased N75 amplitudes, suggesting abnormalities in attention, and longer P110 latencies, indicating a reduction in speed of neural processing, possibly due to deficits in myelination or reduced dopamine levels in brain and retina. Similarly, higher lifetime Phe levels and Index of Dietary Control (IDC) were associated with decreased MMN amplitudes, suggesting a reduced ability to respond to stimulus change and poorer triggering of the frontally mediated attention switch. In summary, the present study in children with PKU investigated bottom-up information processing, i.e., triggered by external events, a fundamental prerequisite for the individual's responsiveness to the outside world. Results provide evidence that quality of dietary control may affect the optimal development of these pre-attentive processes, and suggest the existence of windows of vulnerability to Phe exposure. [ABSTRACT FROM AUTHOR]

Can the sequence in which ad exposures are generated across various ad formats enhance or inhibit communication outcomes in low-involvement situations? This study compares the effect of self-selected and forced-exposure (or intrusive) ad exposure sequences with repeated exposures of single ad formats on brand recall, brand attitude and stimulus-based inclusion in the consideration set. Analysis of experimental data shows that the sequence of self-selected ad formats that induce pre-attentive processing of ad information followed by forced-exposure ad formats that induce conscious processing, leads to superior outcomes compared with others. Prior research on priming supports the findings and implications for media planning, are addressed. [ABSTRACT FROM AUTHOR]

Abstract: We compared the pre-attentive processing in patients with a major depressive disorder (MDD) and matched healthy controls as indexed by the visual mismatch negativity (vMMN) elicited by exposure duration of visual stimuli randomly presented on both peripheral visual fields. To obtain the memory-comparison-based visual MMN, the role of standard and deviant stimuli was reversed in separate blocks. Compared with healthy participants, MDD patients exhibited decreased MMN amplitudes of long duration deviant only and this deficit was not correlated with the depression severity. These data suggests functional impairment of pre-attentive basic visual information processing in MDD patients. [Copyright &y& Elsevier]

Abstract: The mismatch negativity (MMN) is observed following rare or unique sensory events, and reflects pre-attentional sensory processing of unexpected stimuli. The MMN is altered in several mental illnesses, including post-traumatic stress disorder (PTSD), but did not yield consistent results. We measured MMN in 27 survivors of the Wenchuan earthquake, including 13 who were diagnosed with PTSD, to determine if pre-attentive processing in the auditory cortex was altered by this disease. The amplitude of MMN was significantly greater in the PTSD group compared to the control group. In contrast, no significant group difference was found in the N1 potential, an event-related potential that reflects cortical transmission of sensory information. These results demonstrated an increased sensitivity to deviant stimuli in PTSD that may reflect a chronic state of hyperarousal and hypervigilance in trauma victims. [Copyright &y& Elsevier]

Abstract: Feature singleton search is faster when the target-defining dimension is repeated, rather than changed, across trials (). A similar dimension repetition benefit has been observed in a non-search (discrimination) task with a single stimulus (). Two experiments examined whether these effects in the two tasks originate from the same or different processing stages. Experiment 1 revealed differential feature-specific effects, and Experiment 2 differential processing of dimensionally redundant target signals between the two types of task. These dissociations support the existence of separable, pre-attentive and post-selective sources of inter-trial effects in the two tasks. [Copyright &y& Elsevier]

The purpose of the present study was to examine the role of trait anxiety and social desirability on skin conductance responses (SCRs) following exposure to masked and unmasked pictures in a non-clinical sample. The most prominent results were found with regard to masked pictures (i.e. subliminal). Higher levels of social desirability were associated with a decrease in SCRs to masked threat pictures (relative to neutral), whereas elevated levels of trait anxiety were associated with an increase in SCRs. This latter effect, however, was mainly seen among participants who simultaneously scored low on social desirability. These results were discussed in terms of trait anxiety (combined with lower social desirability scores) being associated with (i) enhanced autonomic responses to threatening information most evident at a pre-attentive level, that (ii) may potentially be a vulnerability marker for anxiety disturbances. [ABSTRACT FROM AUTHOR]

Abstract: The aim of this study was to record valid visual mismatch negativity (V-MMN) to a circular black–white windmill pattern. Seven adults were instructed to pay attention to a story through the earphones. The ratio of the standard (S), deviant (D) and target (T) stimuli was 8:1:1, and they appeared in a random sequence with inter-stimulus interval for 800 ms. The difference among the three stimuli was the number of vanes. ERPs were recorded from 20 sites over the scalp. The number of vanes in each stimulus was systematically changed to observe the relationship among the ERPs to the S, D and T stimuli. P300 was only obtained in response to the T stimulus. A negative potential appeared during the period of 150–300 ms after the stimulus onset by subtracting the ERPs to the S stimulus from those of the D stimulus. This negativity was distributed over the occipito-temporal region. Characteristics of this negativity were similar to those of auditory MMN. V-MMN in our study consisted of early (150–200 ms, MMN1) and late (200–300 ms, MMN2) components. The magnitudes of MMN1 and MMN2 were not altered with varying the D and T stimuli. However, the peak latency of MMN2 was significantly altered with varying the D stimuli, but not MMN1. Therefore, valid V-MMN can be recorded by the windmill patterns during auditory attention. [Copyright &y& Elsevier]

Is apparent object size represented in pre-attentive vision and can it influence visual search for size-defined targets in a spatially parallel manner? This question was investigated, using the Müller-Lyer illusion. Observers searched for a target line that was longer than the distractor lines. Test lines could be presented without context arrows (control); be adjoined by obtuse-angle context arrows (arrow heads pointing inward), making the lines appear longer; or by acute-angle arrows (heads pointing outward), making the lines appear shorter. These apparent-length modulations were larger for the target than for the distractor lines, thereby increasing and, respectively, decreasing the target– distractor length contrast. In line with these changes in contrast, target detection was found to be expedited by obtuse-angle arrows and impeded by acute-angle arrows, independently of the number of elements in the display. This finding provides further evidence for the pre-attentive processing of apparent object size. [ABSTRACT FROM AUTHOR]