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148 results on '"Prendergast, B. D."'

14. Dual quantitative coronary angiography accurately quantifies intracoronary thrombotic burden in patients with acute coronary syndrome: Comparison with optical coherence tomography imaging

Author

Vergallo, Rocco, Porto, Italo, De Maria, Giovanni Luigi, D'Amario, D., Annibali, Gianmarco, Galli, Mattia, Migliaro, Stefano, Buccimazza, G., Aurigemma, Cristina, Leone, Antonio Maria, Niccoli, Giampaolo, Kharbanda, R., Burzotta, Francesco, Prendergast, B. D., Channon, K. M., Trani, Carlo, Banning, A. P., Crea, Filippo, Vergallo R., Porto I. (ORCID:0000-0002-9854-5046), De Maria G. L. (ORCID:0000-0003-3572-1855), Annibali G., Galli M., Migliaro S., Aurigemma C., Leone A. M. (ORCID:0000-0002-1276-9883), Niccoli G. (ORCID:0000-0002-3187-6262), Burzotta F. (ORCID:0000-0002-6569-9401), Trani C. (ORCID:0000-0001-9777-013X), Crea F. (ORCID:0000-0001-9404-8846), Vergallo, Rocco, Porto, Italo, De Maria, Giovanni Luigi, D'Amario, D., Annibali, Gianmarco, Galli, Mattia, Migliaro, Stefano, Buccimazza, G., Aurigemma, Cristina, Leone, Antonio Maria, Niccoli, Giampaolo, Kharbanda, R., Burzotta, Francesco, Prendergast, B. D., Channon, K. M., Trani, Carlo, Banning, A. P., Crea, Filippo, Vergallo R., Porto I. (ORCID:0000-0002-9854-5046), De Maria G. L. (ORCID:0000-0003-3572-1855), Annibali G., Galli M., Migliaro S., Aurigemma C., Leone A. M. (ORCID:0000-0002-1276-9883), Niccoli G. (ORCID:0000-0002-3187-6262), Burzotta F. (ORCID:0000-0002-6569-9401), Trani C. (ORCID:0000-0001-9777-013X), and Crea F. (ORCID:0000-0001-9404-8846)

Abstract

Background: Dual quantitative coronary angiography (QCA) has been recently tested for assessment of intracoronary thrombus volume in experimental models. The present study aimed to validate dual QCA in vivo for the assessment of thrombus burden by exploring the correlations between dual QCA-thrombus volume and optical coherence tomography (OCT)-derived indices of thrombotic burden.Methods and results: Fifty-one patients with ACS and angiographic evidence of thrombus undergoing OCT of the culprit lesion before stenting were included. Dual QCA-thrombus volume was calculated as difference between edge-detection and video-densitometry area functions along the target segment. Culprit lesion was categorized using the Ambrose's and AHA/ACC angiographic classifications. Thrombus volume (mean thrombus area x thrombus length), thrombus burden [(mean thrombus area/mean lumen area) x 100] and Prati thrombus score (number of quadrants with thrombus) were measured by OCT, and the presence of plaque rupture (PR) or intact fibrous cap (IFC) was assessed. Dual QCA-thrombus volume correlated significantly with OCT-thrombus volume (R = 0.791), thrombus burden (R = 0.767) and Prati thrombus score (R = 0.600) (all p < 0.001). Dual-QCA thrombus volume was significantly higher in patients with PR compared with those with IFC (3.48 mm(3) [1.45-11.26] vs. 1.69 mm(3) [0.09-5.02], p=0.013). Compared with IFC, PR showed higher prevalence of eccentric type II Ambrose lesion (41.7% vs. 7.4%, p = 0.004), complex B2/C lesion (87.5% vs. 55.6%, p=0.012), and heavy calcification (29.2% vs. 3.7%, p=0.013).Conclusions: Dual QCA analysis appears to be a promising tool for quantification of intracoronary thrombus in vivo. This novel methodology may be useful to guide intracoronary thrombus removal during percutaneous coronary intervention and to aid prognostic stratification in patients with ACS. (C) 2019 Elsevier B.V. All rights reserved.

Published
2019

21. 3326Infective endocarditis after transcatheter aortic valve implantation: findings from a UK nationwide linkage study

Author

Cahill, T J, primary, Raby, J, additional, Jewell, P D, additional, Brennan, P F, additional, Banning, A P, additional, Byrne, J, additional, Kharbanda, R K, additional, MacCarthy, P A, additional, Thornhill, M H, additional, Sandoe, J A T, additional, Spence, M S, additional, Hildick-Smith, D, additional, Redwood, S, additional, and Prendergast, B D, additional

Published
2019
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29. Contemporary epidemiology of infective endocarditis in patients with congenital heart disease: A UK prospective study.

Author

Cahill, TJ, Jewell, PD, Denne, L, Franklin, RC, Frigiola, A, Orchard, E, Prendergast, BD, Cahill, T J, Jewell, P D, Franklin, R C, and Prendergast, B D

Abstract

Objectives: Infective endocarditis is a life-threatening complication of congenital heart disease (CHD), but there are few studies concerning the contemporary risk profile, preceding invasive procedures and outcomes in this patient population. The aim of this study was to investigate the epidemiology of infective endocarditis (IE) in patients with CHD.Methods: Cases of IE in children and adults with CHD were prospectively recorded as part of the UK National Institute for Cardiovascular Outcomes Research (NICOR) National Congenital Heart Disease Audit. Patients were entered into the database between April 2008 and March 2016.Results: Eight hundred episodes of IE were recorded in 736 patients with CHD. Sixty-five patients (9%) were infants (aged <1 year), 235 (32%) were children (aged 1-15 years), and 436 (59%) were adults (aged >15 years). The most common diagnoses were Tetralogy of Fallot (n = 150, 22.8%), ventricular septal defect (n = 129, 19.6%) and bicuspid aortic valve (n = 70, 10.7%). Dental procedures preceded 67 of 635 episodes (11%) of IE, and non-dental invasive procedures preceded 177 of 644 episodes (27.4%). The most common causative organisms were streptococci, accounting for 40% of cases. Overall in-hospital mortality was 6.7%. On multivariable analysis, adverse factors associated with in-hospital mortality were staphylococcal infection and presence of an underlying atrioventricular septal defect.Conclusions: Infective endocarditis in patients with CHD is an ongoing clinical challenge. In contemporary practice in tertiary congenital centers, 1 of 15 patients do not survive to hospital discharge. Streptococci remain the most common causative organism, and antecedent dental or medical procedures were undertaken in a significant minority in the 3 months before diagnosis. The presence of an atrioventricular septal defect or staphylococcal infection is associated with significantly increased risk of early mortality. [ABSTRACT FROM AUTHOR]

Published
2019
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31. Adjuncts to transcatheter aortic valve implantation.

Author

McConkey, HZR, Arri, SS, Joseph, JP, Prendergast, BD, Redwood, S, Arri, S S, Joseph, J P, and Prendergast, B D

Subjects
CHEMOEMBOLIZATION, AORTIC valve transplantation, ADJUNCTIVE behavior, AORTIC stenosis treatment, CARDIOVASCULAR diseases
Abstract

Introduction: The appreciable rise in percutaneous valve procedures has been pursued by a wave of development in advanced technology to help guide straightforward, streamlined and safe intervention. This review article aims to highlight the adjunctive devices, tools and techniques currently used in transcatheter aortic valve implantation procedures to avoid potential pitfalls. Areas covered: The software and devices featured here are at the forefront of technological advances, most of which are not yet in widespread use. These products have been discussed in national and international structural intervention conferences and the authors felt it important to showcase particularly well designed adjuncts that improve procedural efficacy and safety. Whilst vascular pre-closure systems are used routinely and are an integral part of these complex cardiovascular procedures, these have been well summarised elsewhere and are beyond the scope of this article. Expert commentary: The rising volume of patients with aortic stenosis who are treatable with TAVI means that this exponential increase in procedures must be accompanied by a steady decline in procedural complications. This section provides an overview of our current perspective, and what we feel the direction of travel will be. [ABSTRACT FROM AUTHOR]

Published
2017
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32. Early change in invasive measures of microvascular function can predict myocardial recovery following PCI for ST-elevation myocardial infarction

Author

Cuculi, F., primary, Dall'Armellina, E., additional, Manlhiot, C., additional, De Caterina, A. R., additional, Colyer, S., additional, Ferreira, V., additional, Morovat, A., additional, Prendergast, B. D., additional, Forfar, J. C., additional, Alp, N. J., additional, Choudhury, R. P., additional, Neubauer, S., additional, Channon, K. M., additional, Banning, A. P., additional, and Kharbanda, R. K., additional

Published
2013
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36. In Response

Author

Prendergast, B D, Banning, A P, and Hall, R J C

Subjects
Letters to the Editor
Published
1996

40. ESC Working Group on Valvular Heart Disease Position Paper: assessing the risk of interventions in patients with valvular heart disease

Author

Rosenhek, R., primary, Iung, B., additional, Tornos, P., additional, Antunes, M. J., additional, Prendergast, B. D., additional, Otto, C. M., additional, Kappetein, A. P., additional, Stepinska, J., additional, Kaden, J. J., additional, Naber, C. K., additional, Acarturk, E., additional, and Gohlke-Barwolf, C., additional

Published
2011
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