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1. Invasive group A streptococcal infections requiring admission to ICU: a nationwide, multicenter, retrospective study (ISTRE study)

Author

Orieux, Arthur, Prevel, Renaud, Dumery, Margot, Lascarrou, Jean-Baptiste, Zucman, Noémie, Reizine, Florian, Fillatre, Pierre, Detollenaere, Charles, Darreau, Cédric, Antier, Nadiejda, Saint-Léger, Mélanie, Schnell, Guillaume, La Combe, Béatrice, Guesdon, Charlotte, Bruna, Franklin, Guillon, Antoine, Varillon, Caroline, Lesieur, Olivier, Grand, Hubert, Bertrand, Benjamin, Siami, Shidasp, Oudeville, Pierre, Besnard, Céline, Persichini, Romain, Bauduin, Pierrick, Thyrault, Martial, Evrard, Mathieu, Schnell, David, Auchabie, Johann, Auvet, Adrien, Rigaud, Jean-Philippe, Beuret, Pascal, Leclerc, Maxime, Berger, Asaël, Ben Hadj Salem, Omar, Lorber, Julien, Stoclin, Annabelle, Guisset, Olivier, Bientz, Léa, Khan, Pierre, Guillotin, Vivien, Lacherade, Jean-Claude, Boyer, Alexandre, Orieux, Arthur, Prevel, Renaud, Dumery, Margot, Lascarrou, Jean-Baptiste, Zucman, Noémie, Reizine, Florian, Fillatre, Pierre, Detollenaere, Charles, Darreau, Cédric, Antier, Nadiejda, Saint-Léger, Mélanie, Schnell, Guillaume, La Combe, Béatrice, Guesdon, Charlotte, Bruna, Franklin, Guillon, Antoine, Varillon, Caroline, Lesieur, Olivier, Grand, Hubert, Bertrand, Benjamin, Siami, Shidasp, Oudeville, Pierre, Besnard, Céline, Persichini, Romain, Bauduin, Pierrick, Thyrault, Martial, Evrard, Mathieu, Schnell, David, Auchabie, Johann, Auvet, Adrien, Rigaud, Jean-Philippe, Beuret, Pascal, Leclerc, Maxime, Berger, Asaël, Ben Hadj Salem, Omar, Lorber, Julien, Stoclin, Annabelle, Guisset, Olivier, Bientz, Léa, Khan, Pierre, Guillotin, Vivien, Lacherade, Jean-Claude, and Boyer, Alexandre

Published
2024
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4. Critically ill patients with infective endocarditis, neurological complications and indication for cardiac surgery: a multicenter propensity-adjusted study

Author

Gros, Alexandre, Seguy, Benjamin, Bonnet, Guillaume, Guettard, Yves-Olivier, Pillois, Xavier, Prevel, Renaud, Orieux, Arthur, Ternacle, Julien, Préau, Sebastien, Lavie-Badie, Yoan, Coupez, Elisabeth, Coudroy, Rémi, Marest, Delphine, Martins, Raphaël P., Gruson, Didier, Tourdias, Thomas, and Boyer, Alexandre

Published
2024
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5. Safety of baricitinib in vaccinated patients with severe and critical COVID-19 sub study of the randomised Bari-SolidAct trial

Author

Viermyr, Hans-Kittil, Tonby, Kristian, Ponzi, Erica, Trouillet-Assant, Sophie, Poissy, Julien, Arribas, José R., Dyon-Tafani, Virginie, Bouscambert-Duchamp, Maude, Assoumou, Lambert, Halvorsen, Bente, Tekin, Nuriye Basdag, Diallo, Alpha, De Gastines, Lucie, Munthe, Ludvig A., Murphy, Sarah Louise, Ueland, Thor, Michelsen, Annika E., Lund-Johansen, Fridtjof, Aukrust, Pål, Mootien, Joy, Dervieux, Benjamin, Zerbib, Yoann, Richard, Jean-Christophe, Prével, Renaud, Malvy, Denis, Timsit, Jean-François, Peiffer-Smadja, Nathan, Roux, Damien, Piroth, Lionel, Ait-Oufella, Hafid, Vieira, Cesar, Dalgard, Olav, Heggelund, Lars, Müller, Karl Erik, Møller, Jannicke Horjen, Kildal, Anders Benjamin, Skogen, Vegard, Aballi, Saad, Sjøberg Øgaard, Jonas Daniel, Dyrhol-Riise, Anne Ma, Tveita, Anders, Alirezaylavasani, Amin, Costagliola, Dominique, Yazdanpanah, Yazdan, Olsen, Inge Christoffer, Dahl, Tuva Børresdatter, Kared, Hassen, Holten, Aleksander Rygh, and Trøseid, Marius

Published
2025
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6. Efficacy of carbapenem vs non carbapenem β-lactam therapy as empiric antimicrobial therapy in patients with extended-spectrum β-lactamase-producing Enterobacterales urinary septic shock: a propensity-weighted multicenter cohort study

Author

Cariou, Erwann, Griffier, Romain, Orieux, Arthur, Silva, Stein, Faguer, Stanislas, Seguin, Thierry, Nseir, Saad, Canet, Emmanuel, Desclaux, Arnaud, Souweine, Bertrand, Klouche, Kada, Guisset, Olivier, Pillot, Jerome, Picard, Walter, Saghi, Tahar, Delobel, Pierre, Gruson, Didier, Prevel, Renaud, and Boyer, Alexandre

Published
2023
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8. Neonatal imprinting of alveolar macrophages via neutrophil-derived 12-HETE

Author

Pernet, Erwan, Sun, Sarah, Sarden, Nicole, Gona, Saideep, Nguyen, Angela, Khan, Nargis, Mawhinney, Martin, Tran, Kim A., Chronopoulos, Julia, Amberkar, Dnyandeo, Sadeghi, Mina, Grant, Alexandre, Wali, Shradha, Prevel, Renaud, Ding, Jun, Martin, James G., Thanabalasuriar, Ajitha, Yipp, Bryan G., Barreiro, Luis B., and Divangahi, Maziar

Published
2023
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10. Immune thrombotic thrombocytopenic purpura in older patients: prognosis and long-term survival

Author

Prevel, Renaud, Roubaud-Baudron, Claire, Gourlain, Samuel, Jamme, Matthieu, Peres, Karine, Benhamou, Ygal, Galicier, Lionel, Azoulay, Elie, Poullin, Pascale, Provôt, François, Maury, Eric, Presne, Claire, Hamidou, Mohamed, Saheb, Samir, Wynckel, Alain, Servais, Aude, Girault, Stéphane, Delmas, Yahsou, Chatelet, Valérie, Augusto, Jean-François, Mousson, Christiane, Perez, Pierre, Halimi, Jean-Michel, Kanouni, Tarik, Lautrette, Alexandre, Charvet-Rumpler, Anne, Deligny, Christophe, Chauveau, Dominique, Veyradier, Agnès, and Coppo, Paul

Published
2019
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13. Training can't always lead to Olympic macrophages

Author

Pernet, Erwan, Prevel, Renaud, and Divangahi, Maziar

Abstract

Trained immunity The dogma that only adaptive immune cells are able to generate immune memory has been challenged by studies in simple organisms (e.g., plants or invertebrates), as well as [...], Although the memory capacity of innate immune cells, termed trained immunity (TI), is a conserved evolutionary trait, the cellular and molecular mechanisms involved are incompletely understood. One fundamental question is whether the induction of TI generates a homogeneous or heterogeneous population of trained cells. In this issue of the JCI, Zhang, Moorlag, and colleagues tackle this question by combining an in vitro model system of TI with single-cell RNA sequencing. The induction of TI in human monocytes resulted in three populations with distinct transcriptomic profiles. Interestingly, the presence of lymphocytes in the microenvironment of monocytes substantially impacted TI. The authors also identified a similar population of monocytes in various human diseases or in individuals vaccinated with bacillus Calmette-Guerin. These insights warrant in-depth analysis of TI in responsive versus nonresponsive immune cells and suggest that modulating TI may provide a strategy for treating infections and inflammatory diseases.

Published
2022
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14. A novel in vitro tubular model to recapitulate features of distal airways: the bronchioid

Author

Maurat, Elise, primary, Raasch, Katharina, additional, Leipold, Alexander, additional, Henrot, Pauline, additional, Zysman, Maeva, additional, Prevel, Renaud, additional, Trian, Thomas, additional, Thumerel, Matthieu, additional, Nassoy, Pierre, additional, Berger, Patrick, additional, Saliba, Antoine-Emmanuel, additional, Andrique, Laetitia, additional, Recher, Gaelle, additional, and Dupin, Isabelle, additional

Published
2023
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15. Food-borne botulism outbreak during the Rugby World Cup linked to marinated sardines in Bordeaux, France, September 2023

Author

Courtot-Melciolle, Léa, primary, Jauvain, Marine, additional, Siefridt, Mona, additional, Prevel, Renaud, additional, Peuchant, Olivia, additional, Guisset, Olivier, additional, Mourissoux, Gaëlle, additional, Diancourt, Laure, additional, Mazuet, Christelle, additional, Delvallez, Gauthier, additional, Boyer, Alexandre, additional, and Orieux, Arthur, additional

Published
2023
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16. The gut microbiota composition is linked to subsequent occurrence of ventilator-associated pneumonia in critically ill patients

Author

Orieux, Arthur, primary, Enaud, Raphaël, additional, Imbert, Sébastien, additional, Boyer, Philippe, additional, Begot, Erwan, additional, Camino, Adrian, additional, Boyer, Alexandre, additional, Berger, Patrick, additional, Gruson, Didier, additional, Delhaes, Laurence, additional, and Prevel, Renaud, additional

Published
2023
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17. Blocking CXCR4 improves pulmonary and cardiac outcomes in a mouse model of early COPD

Author

Dupin, Isabelle, primary, Henrot, Pauline, additional, Maurat, Elise, additional, Abohalaka, Reshed, additional, Chaigne, Sébastien, additional, El Hamrani, Dounia, additional, Eyraud, Edmée, additional, Prevel, Renaud, additional, Estèves, Pauline, additional, Campagnac, Marilyne, additional, Dubreuil, Marielle, additional, Cardouat, Guillaume, additional, Bouchet, Clément, additional, Ousova, Olga, additional, Dupuy, Jean-William, additional, Trian, Thomas, additional, Thumerel, Matthieu, additional, Bégueret, Hugues, additional, Girodet, Pierre-Olivier, additional, Marthan, Roger, additional, Zysman, Maéva, additional, Freund-Michel, Véronique, additional, and Berger, Patrick, additional

Published
2023
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22. Bronchial smooth muscle remodelling impacts the exacerbation frequency of severe preschool wheezers

Author

Beaufils, Fabien, primary, Esteves, Pauline, additional, Enaud, Raphael, additional, Prevel, Renaud, additional, Henrot, Pauline, additional, Campagnac, Marilyne, additional, Maurat, Elise, additional, michelet, marine, additional, Lavrand, Frederic, additional, Bégueret, Hugues, additional, Trian, Thomas, additional, Fayon, Michael, additional, and Berger, Patrick, additional

Published
2023
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23. Lung Mycobiota α-Diversity Is Linked to Severity in Critically Ill Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Author

Enaud, Raphaël, primary, Sioniac, Pierre, additional, Imbert, Sebastien, additional, Janvier, Pierre-Laurent, additional, Camino, Adrian, additional, Bui, Hoang-Nam, additional, Pillet, Odile, additional, Orieux, Arthur, additional, Boyer, Alexandre, additional, Berger, Patrick, additional, Gruson, Didier, additional, Delhaes, Laurence, additional, and Prevel, Renaud, additional

Published
2023
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25. Additional file 4 of Efficacy of carbapenem vs non carbapenem β-lactam therapy as empiric antimicrobial therapy in patients with extended-spectrum β-lactamase-producing Enterobacterales urinary septic shock: a propensity-weighted multicenter cohort study

Author

Cariou, Erwann, Griffier, Romain, Orieux, Arthur, Silva, Stein, Faguer, Stanislas, Seguin, Thierry, Nseir, Saad, Canet, Emmanuel, Desclaux, Arnaud, Souweine, Bertrand, Klouche, Kada, Guisset, Olivier, Pillot, Jerome, Picard, Walter, Saghi, Tahar, Delobel, Pierre, Gruson, Didier, Prevel, Renaud, and Boyer, Alexandre

Abstract

Additional file 4. Standardized differences before/after adjustment by weighting (95% CI).

Published
2023
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26. Additional file 2 of Efficacy of carbapenem vs non carbapenem β-lactam therapy as empiric antimicrobial therapy in patients with extended-spectrum β-lactamase-producing Enterobacterales urinary septic shock: a propensity-weighted multicenter cohort study

Author

Cariou, Erwann, Griffier, Romain, Orieux, Arthur, Silva, Stein, Faguer, Stanislas, Seguin, Thierry, Nseir, Saad, Canet, Emmanuel, Desclaux, Arnaud, Souweine, Bertrand, Klouche, Kada, Guisset, Olivier, Pillot, Jerome, Picard, Walter, Saghi, Tahar, Delobel, Pierre, Gruson, Didier, Prevel, Renaud, and Boyer, Alexandre

Abstract

Additional file 2. Interventions, source control and antimicrobial therapy.

Published
2023
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27. Additional file 3 of Efficacy of carbapenem vs non carbapenem β-lactam therapy as empiric antimicrobial therapy in patients with extended-spectrum β-lactamase-producing Enterobacterales urinary septic shock: a propensity-weighted multicenter cohort study

Author

Cariou, Erwann, Griffier, Romain, Orieux, Arthur, Silva, Stein, Faguer, Stanislas, Seguin, Thierry, Nseir, Saad, Canet, Emmanuel, Desclaux, Arnaud, Souweine, Bertrand, Klouche, Kada, Guisset, Olivier, Pillot, Jerome, Picard, Walter, Saghi, Tahar, Delobel, Pierre, Gruson, Didier, Prevel, Renaud, and Boyer, Alexandre

Abstract

Additional file 3. Distribution of the propensity to receive carbapenem before vs after adjustment to the propensity score. Patients’ microbiological presentation, bacterial species and antibiotic susceptibility test.

Published
2023
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28. Additional file 1 of Efficacy of carbapenem vs non carbapenem β-lactam therapy as empiric antimicrobial therapy in patients with extended-spectrum β-lactamase-producing Enterobacterales urinary septic shock: a propensity-weighted multicenter cohort study

Author

Cariou, Erwann, Griffier, Romain, Orieux, Arthur, Silva, Stein, Faguer, Stanislas, Seguin, Thierry, Nseir, Saad, Canet, Emmanuel, Desclaux, Arnaud, Souweine, Bertrand, Klouche, Kada, Guisset, Olivier, Pillot, Jerome, Picard, Walter, Saghi, Tahar, Delobel, Pierre, Gruson, Didier, Prevel, Renaud, and Boyer, Alexandre

Abstract

Additional file 1. Patients’ imaging presentation.

Published
2023
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29. CXCR4 blockade alleviates pulmonary and cardiac outcomes in early COPD

Author

Dupin, Isabelle, primary, Henrot, Pauline, additional, Maurat, Elise, additional, Abohalaka, Reshed, additional, Chaigne, Sébastien, additional, Hamrani, Dounia El, additional, Eyraud, Edmée, additional, Prevel, Renaud, additional, Esteves, Pauline, additional, Campagnac, Maryline, additional, Dubreuil, Marielle, additional, Cardouat, Guillaume, additional, Bouchet, Clément, additional, Ousova, Olga, additional, Dupuy, Jean-William, additional, Trian, Thomas, additional, Thumerel, Matthieu, additional, Bégueret, Hugues, additional, Girodet, Pierre-Olivier, additional, Marthan, Roger, additional, Zysman, Maeva, additional, Freund-Michel, Véronique, additional, and Berger, Patrick, additional

Published
2023
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32. Central Nervous System Cryptococcosis in Patients With Sarcoidosis: Comparison With Non-sarcoidosis Patients and Review of Potential Pathophysiological Mechanisms

Author

Prevel, Renaud, Guillotin, Vivien, Imbert, Sébastien, Blanco, Patrick, Delhaes, Laurence, and Duffau, Pierre

Subjects
General Medicine
Abstract

IntroductionCryptococcusspp. infection of the central nervous system (CINS) is a devastating opportunistic infection that was historically described in patients with acquired immunodeficiency syndrome (AIDS).Cryptococcusspp. infections are also associated with sarcoidosis; the impairment of cell-mediated immunity and long-term corticosteroid therapy being evoked to explain this association. Nevertheless, this assertion is debated and the underlying pathophysiological mechanisms are still unknown. The aims of this study were (i) to describe the clinical and biological presentation, treatments, and outcomes of CINS patients with and without sarcoidosis and (ii) to review the pathophysiological evidence underlying this clinical association.Patients and MethodsEvery patient with positive cerebrospinal fluid (CSF) cryptococcal antigen testing, India ink preparation, and/or culture from January 2015 to December 2020 at a tertiary university hospital were included, and patients with sarcoidosis were compared with non-sarcoidosis patients. Quantitative variables are presented as mean ± SD and are compared using the Mann-Whitney Wilcoxon rank-sum test. Categorical variables are expressed as the number of patients (percentage) and compared using the χ2or Fisher's tests.ResultsDuring the study period, 16 patients experienced CINS, of whom 5 (31%) were associated with sarcoidosis. CINS symptoms, biological, and CSF features were similar between CINS patients with and without sarcoidosis except regarding CD4 cells percentages and CD4/CD8 ratio that was higher in those with sarcoidosis (47 ± 12 vs. 22 ± 18,p= 0.02 and 2.24 ± 1.42 vs. 0.83 ± 1.10,p= 0.03, respectively). CINS patients with sarcoidosis had less often positive blood antigen testing than those without sarcoidosis (2/5 vs. 11/11,p= 0.02). CINS patients with and without sarcoidosis were treated with similar drugs, but patients with sarcoidosis had a shorter length of treatment. CD4 cell levels do not seem to explain the association between sarcoidosis and cryptococcosis.ConclusionSarcoidosis was the most frequently associated condition with CINS in this study. CINS patients associated with sarcoidosis had overall similar clinical and biological presentation than CINS patients associated with other conditions but exhibited a lower rate of positive blood cryptococcal antigen testing and higher CD4/CD8 T cells ratio. Pathophysiological mechanisms underlying this association remain poorly understood but B-1 cell deficiency or lack of IgM could be a part of the explanation. Another plausible mechanism is the presence of anti-granulocyte-macrophage colony-stimulating factor (GM-CSF) antibodies in a subset of patients with sarcoidosis, which could impair macrophage phagocytic function. Further studies are strongly needed to better understand those mechanisms and to identify at-risk patients.

Published
2022
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33. Additional file 1 of Gut bacteriobiota and mycobiota are both associated with Day-28 mortality among critically ill patients

Author

Prevel, Renaud, Enaud, Raphaël, Orieux, Arthur, Camino, Adrian, Berger, Patrick, Boyer, Alexandre, Delhaes, Laurence, and Gruson, Didier

Subjects
respiratory system
Abstract

Additional file 1. Supplemental Figure 1. Non metric Bray-curtis analysis of β-diversity of the V3-V4 sequencing run. XXA, B, and C samples: gut bacteriobiota samples. GXX: lung bacteriobiota samples. BlancV3-V4: negative control. Mock: mock community. Supplemental Figure 2. Non metric Bray-curtis analysis of β-diversity of ITS2 sequencing run. XXA, B, and C samples: gut mycobiota samples. GXX: lung mycobiota samples. Blanc1 and blanc2: negative controls. Mock: mock community.

Published
2022
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35. Clinical trajectories and impact of acute kidney disease after acute kidney injury in the intensive care unit: a 5-year single-centre cohort study.

Author

Orieux, Arthur, Prezelin-Reydit, Mathilde, Prevel, Renaud, Combe, Christian, Gruson, Didier, Boyer, Alexandre, and Rubin, Sébastien

Subjects
ACUTE kidney failure, INTENSIVE care units, KIDNEY diseases, DISEASE risk factors, ACUTE diseases
Abstract

Background Patients suffering from acute kidney injury(AKI) in the intensive care unit (ICU) can have various renal trajectories and outcomes. Aims were to assess the various clinical trajectories after AKI in the ICU and to determine risk factors for developing chronic kidney disease (CKD). Methods We conducted a prospective 5-year follow-up study in a medical ICU at Bordeaux University Hospital (France). The patients who received invasive mechanical ventilation, catecholamine infusion or both and developed an AKI from September 2013 to May 2015 were included. In the Cox analysis, the violation of the proportional hazard assumption for AKD was handled using appropriate interaction terms with time, resulting in a time-dependent hazard ratio (HR). Results A total of 232 patients were enrolled, with an age of 62 ± 16 years and a median follow-up of 52 days (interquartile range 6–1553). On day 7, 109/232 (47%) patients progressed to acute kidney disease (AKD) and 66/232 (28%) recovered. A linear trajectory (AKI, AKD to CKD) was followed by 44/63 (70%) of the CKD patients. The cumulative incidence of CKD was 30% [95% confidence interval (CI) 24–36] at the 5-year follow-up. In a multivariable Cox model, in the 6 months following AKI, the HR for CKD was higher in AKD patients [HR 29.2 (95% CI 8.5–100.7); P  < 0.0001). After 6 months, the HR for CKD was 2.2 (95% CI 0.6–7.9; P  = 0.21; n  = 172 patients). Conclusion There were several clinical trajectories of kidney disease after ICU-acquired AKI. CKD risk was higher in AKD patients only in the first 6 months. Lack of renal recovery rather than AKD per se was associated with the risk of CKD. [ABSTRACT FROM AUTHOR]

Published
2023
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36. High-resolution Free-breathing late gadolinium enhancement Cardiovascular magnetic resonance to diagnose myocardial injuries following COVID-19 infection

Author

Bustin, Aurélien, primary, Sridi, Soumaya, additional, Gravinay, Pierre, additional, Legghe, Benoit, additional, Gosse, Philippe, additional, Ouattara, Alexandre, additional, Rozé, Hadrien, additional, Coste, Pierre, additional, Gerbaud, Edouard, additional, Desclaux, Arnaud, additional, Boyer, Alexandre, additional, Prevel, Renaud, additional, Gruson, Didier, additional, Bonnet, Fabrice, additional, Issa, Nahema, additional, Montaudon, Michel, additional, Laurent, François, additional, Stuber, Matthias, additional, Camou, Fabrice, additional, and Cochet, Hubert, additional

Published
2021
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38. Characterization of acute kidney injury in critically ill patients with severe coronavirus disease 2019

Author

Rubin, Sébastien, primary, Orieux, Arthur, primary, Prevel, Renaud, primary, Garric, Antoine, primary, Bats, Marie-Lise, primary, Dabernat, Sandrine, primary, Camou, Fabrice, primary, Guisset, Olivier, primary, Issa, Nahema, primary, Mourissoux, Gaelle, primary, Dewitte, Antoine, primary, Joannes-Boyau, Olivier, primary, Fleureau, Catherine, primary, Rozé, Hadrien, primary, Carrié, Cédric, primary, Petit, Laurent, primary, Clouzeau, Benjamin, primary, Sazio, Charline, primary, Bui, Hoang-Nam, primary, Pillet, Odile, primary, Rigothier, Claire, primary, Vargas, Frederic, primary, Combe, Christian, primary, Gruson, Didier, primary, and Boyer, Alexandre, primary

Published
2020
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39. Characterisation of Acute Kidney Injury in Critically Ill Patients with Severe Coronavirus Disease-2019 (COVID-19)

Author

Rubin, Sébastien, primary, Orieux, Arthur, additional, Prevel, Renaud, additional, Garric, Antoine, additional, Bats, Marie-Lise, additional, Dabernat, Sandrine, additional, Camou, Fabrice, additional, Guisset, Olivier, additional, Issa, Nahema, additional, Mourissoux, Gaelle, additional, Dewitte, Antoine, additional, Joannes-Boyau, Olivier, additional, Fleureau, Catherine, additional, Rozé, Hadrien, additional, Carrié, Cédric, additional, Petit, Laurent, additional, Clouzeau, Benjamin, additional, Sazio, Charline, additional, Bui, Hoang-Nam, additional, Pillet, Odile, additional, Rigothier, Claire, additional, Vargas, Frederic, additional, Combe, Christian, additional, Gruson, Didier, additional, and Boyer, Alexandre, additional

Published
2020
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40. Prognostic and Long-term Survival of Immune Thrombotic Thrombocytopenic Purpura in older patients

Author

Prevel, Renaud, Roubaud-Roubaud, Claire, Gourlain, Samuel, Jamme, Matthieu, Pérès, Karine, Benhamou, Ygal, Galicier, Lionel, Azoulay, Elie, Poullin, Pascale, Provôt, François, Maury, Eric, Presne, Claire, Hamidou, Mohamed, Saheb, Samir, Wynckel, Alain, Servais, Aude, Girault, Stéphane, Delmas, Yahsou, Châtelet, Valérie, Augusto, Jean-François, Mousson, Christiane, Perez, Pierre, Halimi, Jean-Michel, Kanouni, Tarik, Lautrette, Alexandre, Charvet Rumpler, Anne, Deligny, Christophe, Chauveau, Dominique, Veyradier, Agnès, Coppo, Paul, CHI Poissy-Saint-Germain, Epidémiologie et Biostatistique [Bordeaux], Université Bordeaux Segalen - Bordeaux 2-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Médecine Interne [CHU Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Immunologie clinique [CHU St-Louis], Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de réanimation médicale, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service d\'hémaphérèse, Hôpital de la Conception, APHM, Marseille, France, Service d'hémaphérèse, Assistance Publique - Hôpitaux de Marseille (APHM)-Hôpital de la Conception [CHU - APHM] (LA CONCEPTION)-Assistance Publique - Hôpitaux de Marseille (APHM)-Hôpital de la Conception [CHU - APHM] (LA CONCEPTION), CHU Saint-Antoine [AP-HP], Laboratoire de Physico-Chimie Moléculaire (LPCM), Université Sciences et Technologies - Bordeaux 1-Centre National de la Recherche Scientifique (CNRS), Service de Néphrologie - Médecine Interne, CHU Amiens-Picardie-hôpital Sud, Service de médecine interne [Nantes], Université de Nantes (UN)-Hôtel-Dieu-Centre hospitalier universitaire de Nantes (CHU Nantes), CHU Pitié-Salpêtrière [AP-HP], Centre Hospitalier Universitaire de Reims (CHU Reims), Département de Néphrologie [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], CHU Limoges, Service de Néphrologie-transplantation-dialyse [Bordeaux], CHU Bordeaux [Bordeaux], Service de Néphrologie-Dialyse-Transplantation rénale [CHU Caen], Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Centre de Recherche en Cancérologie Nantes-Angers (CRCNA), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM)-Hôtel-Dieu de Nantes-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Laennec-Centre National de la Recherche Scientifique (CNRS)-Faculté de Médecine d'Angers-Centre hospitalier universitaire de Nantes (CHU Nantes), Service de Néphrologie, CHU Clermont-Ferrand, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Service de néphrologie et immunologie clinique [CHRU Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-Hôpital Bretonneau-Université de Tours (UT), Unité de transplantation allogénique [CHU de Montpellier], Département d'Hématologie [CHU de Montpellier], Centre Hospitalier Universitaire de Montpellier (CHU Montpellier )-Centre Hospitalier Universitaire de Montpellier (CHU Montpellier ), Unité de soins intensifs [Clermont Ferrand], CHU Clermont-Ferrand-CHU Gabriel Montpied [Clermont-Ferrand], Laboratoire Microorganismes : Génome et Environnement (LMGE), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Hôpital Pierre Zobda-Quitman [CHU de la Martinique], CHU de la Martinique [Fort de France], Service de Néphrologie et Immunopathologie Clinique, Centre Hospitalier Universitaire de Toulouse, PRES Université de Toulouse, Hémostase et biologie vasculaire, Université Paris-Sud - Paris 11 (UP11)-IFR93-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'hématologie clinique et de thérapie cellulaire [CHU Saint-Antoine], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Saint-Antoine [AP-HP], Université Paris Diderot - Paris 7 (UPD7)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Service de néphrologie et immunologie clinique [CHRU Tours] (EA4245 UT), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-Hôpital Bretonneau-Université de Tours, Université Sciences et Technologies - Bordeaux 1 (UB)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Service Médecine interne et immunopathologie clinique [CHU Toulouse], Pôle IUCT [CHU Toulouse], and Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)

Subjects
[SDV.MP.PRO]Life Sciences [q-bio]/Microbiology and Parasitology/Protistology, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, ComputingMilieux_MISCELLANEOUS, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience

Published
2019
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41. MOESM1 of Determination of reliable lung function parameters in intubated mice

Author

Bonnardel, Eline, Prevel, Renaud, Campagnac, Marilyne, Dubreuil, Marielle, Marthan, Roger, Berger, Patrick, and Dupin, Isabelle

Abstract

Additional file 1: Table S1. Association between parameters measured using tracheostomy and orotracheal intubation. Table S2. Agreement between the measurements of parameters by tracheostomy and orotracheal intubation. Table S3. Association between the difference and the average of the two methods for the measurements using tracheostomy and orotracheal intubation. Table S4. Association between parameters measured using tracheostomy and orotracheal intubation, both using the intubation cannula. Table S5. Agreement between the measurements of parameters by tracheostomy and orotracheal intubation, both using the intubation cannula. Table S6. Association between the difference and the average of the two methods for the measurements using tracheostomy and orotracheal intubation, both using the intubation cannula. Table S7. Association between parameters measured using orotracheal intubation at day 0 et day 19. Figure S1. Evaluation of peak expiratory flow and the FEV0.1/FVC ratio measurements obtained in mice using orotracheal intubation and tracheostomy. Figure S2. Evaluation of lung function measurement in C57BL/6â J mice that have been either intubated or tracheostomized. Figure S. Evaluation of quality of the single compartment, contant phase and Salazar-Knowles models fit. Figure S4. Evaluation of the curvature of the upper portion of the deflation limb of the Pressure-Volume loop and the area enclosed by the same curve, obtained in mice using orotracheal intubation and tracheostomy. Figure S5. Relationships between the respiratory system compliance (Crs) and the compliance (C) measured in intubated and tracheostomized BALB/cJ (A) and C57BL/6â J mice (B). Figure S6. Evaluation of peak expiratory flow and the FEV0.1/FVC ratio measurements obtained in mice using orotracheal intubation and tracheostomy, both using the intubation cannula. Figure S7. Evaluation of the curvature of the upper portion of the deflation limb of the Pressure-Volume loop and the area enclosed by the same curve, obtained in mice using orotracheal intubation and tracheostomy, both using the intubation cannula. (DOCX 757 kb)

Published
2019
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49. Tailoring Empirical Antimicrobial Therapy in Subjects With Ventilator-Associated Pneumonia With a 10-Hour E-Test Approach.

Author

Boyer, Alexandre, Goret, Julien, Clouzeau, Benjamin, Romen, Antoine, Prevel, Renaud, Lhomme, Edouard, Vargas, Frédéric, Hilbert, Gilles, Bébéar, Cecile, Gruson, Didier, and M'Zali, Fatima

Subjects
ANTIBIOTICS, ACADEMIC medical centers, BRONCHOALVEOLAR lavage, CULTURE media (Biology), INTENSIVE care units, MICROBIAL sensitivity tests, DESCRIPTIVE statistics, VENTILATOR-associated pneumonia
Abstract

BACKGROUND: In a previous study of subjects suspected of having ventilator-associated pneumonia, a rapid susceptibility testing approach by using ETEST (BioMérieux) strips directly applied to bronchoalveolar lavage samples provided valuable information at hour 24. The primary objective of this study was to assess a new direct specimen testing by using an even more-rapid E-test approach (at hour 10), which could promote an early de-escalation of the antimicrobial therapy. METHODS: Twenty-eight subjects with ventilator-associated pneumonia admitted to a medical ICU were prospectively included. In parallel with standard routine methods, E-test strips were directly applied onto agar plates seeded with bronchoalveolar lavage samples and were analyzed after 10 h of incubation. E-test results were used to identify potential drug choices by simulating clinical decision making if the microscopy results had been available at the point of care. These choices were analyzed for concordance with the narrowest adequate antimicrobial therapy according to the Minimum Inhibitory Concentrations (MICs) provided by the reference method (ie, the laboratory routine diagnostic). RESULTS: At hour 10, direct specimen testing was readable in 18 of 28 bronchoalveolar lavage samples (64%). Total agreement between the 10-h direct specimen testing approach and the laboratory routine diagnostic approach was 90%, with a sensitivity of 83% and a specificity of 95%, with 8% major errors and 3% very major errors. The concordance between the 2 tests was very good (kappa = 0.79). If the 10-h E-test results were taken into account, then an early de-escalation strategy would have been possible in 10 of 18 cases (55%) at hour 10. CONCLUSIONS: This rapid susceptibility testing approach provided early (10 h) and valuable information that could lead to an early adjustment of empirical antimicrobial treatment in a ventilator-associated pneumonia setting. [ABSTRACT FROM AUTHOR]

Published
2019
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